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KR830007675A - 6- [D-(-)-α- (4-ethyl2,3-dioxo-1-piperazino carbonylamino) -phenyl (or hydroxy phenyl) acetamino] phenylic acid and its salt - Google Patents

6- [D-(-)-α- (4-ethyl2,3-dioxo-1-piperazino carbonylamino) -phenyl (or hydroxy phenyl) acetamino] phenylic acid and its salt Download PDF

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Publication number
KR830007675A
KR830007675A KR1019810003767A KR810003767A KR830007675A KR 830007675 A KR830007675 A KR 830007675A KR 1019810003767 A KR1019810003767 A KR 1019810003767A KR 810003767 A KR810003767 A KR 810003767A KR 830007675 A KR830007675 A KR 830007675A
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KR
South Korea
Prior art keywords
hydroxy
phenyl
ethyl2
piperazino
carbonylamino
Prior art date
Application number
KR1019810003767A
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Korean (ko)
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KR830001969B1 (en
Inventor
김영설
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김영설
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 김영설 filed Critical 김영설
Priority to KR1019810003767A priority Critical patent/KR830001969B1/en
Priority to JP57005306A priority patent/JPS5867694A/en
Priority to FI820760A priority patent/FI820760L/en
Priority to BE2/59617A priority patent/BE892370A/en
Priority to AU82675/82A priority patent/AU8267582A/en
Priority to ES511709A priority patent/ES8307816A1/en
Priority to IN502/CAL/82A priority patent/IN155630B/en
Priority to NO822870A priority patent/NO822870L/en
Priority to DK435682A priority patent/DK435682A/en
Priority to IT68169/82A priority patent/IT1157064B/en
Priority to ES521036A priority patent/ES521036A0/en
Priority to ES521035A priority patent/ES521035A0/en
Application granted granted Critical
Publication of KR830001969B1 publication Critical patent/KR830001969B1/en
Publication of KR830007675A publication Critical patent/KR830007675A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C07F9/146—Esters of phosphorous acids containing P-halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음No content

Description

6-[D-(-)-α-(4-에칠2,3-디옥소-1-피페라지노 카보닐아미노)-페닐(또는 하이드록시 페닐)아세트아미도]페니실란산 및 그 염의 제조방법.Preparation of 6- [D-(-)-α- (4-ethyl2,3-dioxo-1-piperazino carbonylamino) -phenyl (or hydroxy phenyl) acetamido] peniclanic acid and salts thereof Way.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

다음 구조식(Ⅱ)의 6-[D-(-)-α-(4-에칠2,3-디옥소-1-피페라지노 카보닐아미노)-페닐(또는 하이드록시 페닐)글리신과 다음 구조식(Ⅲ)의 N-하이드록시산아미드와 다음 구조식(Ⅴ)의 디싸이클로헥실카보디이미드 촉매하에서 반응시켜 다음 구조식(Ⅳ)의 산무수물을 제조한 다음 다음 구조식(Ⅵ)의 6-아미노페니실란산과 반응시켜 다음구조식(I)의 6-[D-(-)-α-(4-에칠2,3-디옥소-1-피페라지노 카보닐아미노)-페닐(또는 하이드록시 페닐)아세트아미도]페니실란산 및 그 염의 제조방법.6- [D-(-)-α- (4-ethyl2,3-dioxo-1-piperazino carbonylamino) -phenyl (or hydroxyphenyl) glycine of the following structural formula (II) and the following structural formula ( The acid anhydride of the following formula (IV) was prepared by reacting N-hydroxy acidamide of III) with a dicyclohexylcarbodiimide catalyst of the following formula (V), followed by the 6-aminophenic silane acid of the following formula (VI). 6- [D-(-)-α- (4-ethyl2,3-dioxo-1-piperazino carbonylamino) -phenyl (or hydroxy phenyl) acetamido of formula (I) ] Phenylanic acid and its salt manufacturing method. 여기서here R은 수소, 수산기이며R is hydrogen, hydroxyl M은 수소, 나트륨, 칼륨, 칼슘등 무기염이거나 탄소수 1-4인 저급 알킬아민이고,M is an inorganic salt such as hydrogen, sodium, potassium, calcium, or lower alkylamine having 1-4 carbon atoms, Z는이다.Z is to be. 제1항에 있어서, 테트라하이드로 후란 용매 존재하에서와 실온의 조건에서 산무수물을 제조하는 제조방법.The process according to claim 1, wherein the acid anhydride is prepared in the presence of a tetrahydrofuran solvent and at room temperature. 제1항에 있어서, N-하이드록시산아미드가 N-하이드록시 썩신아미드인 제조방법.The process according to claim 1, wherein the N-hydroxy acid amide is N-hydroxy rosinamide. 제1항에 있어서, N-하이드록시산아미드가 N-하이드록시 푸탈아미드인 제조방법.The process according to claim 1, wherein the N-hydroxy acid amide is N-hydroxy futhamide. 제1항에 있어서, N-하이드록시산아미드가 N-하이드록시 글루타아미드인 제조방법.The process according to claim 1, wherein the N-hydroxy acid amide is N-hydroxy glutaamide. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810003767A 1981-10-06 1981-10-06 6- ｛D-(-) α- (4-ethyl-2.3-dioxo-1 piperazinocarbonylamino) phenyl (or hydroxyphenyl) acetamido peniclanic acid and a method for preparing the salt thereof KR830001969B1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR1019810003767A KR830001969B1 (en) 1981-10-06 1981-10-06 6- ｛D-(-) α- (4-ethyl-2.3-dioxo-1 piperazinocarbonylamino) phenyl (or hydroxyphenyl) acetamido peniclanic acid and a method for preparing the salt thereof
JP57005306A JPS5867694A (en) 1981-10-06 1982-01-16 Manufacture of 6-(d-(-)-alpha-(4-ethyl-2,3- dioxo-1-piperadinocarbonylamino)-penyl( or hydroxypenyl)acetamide)penicillanic acid and salt of same
FI820760A FI820760L (en) 1981-10-06 1982-03-04 NY PROCESS FOER FRAMSTAELLNING AV PENICILLIN- OCH KEFALOSPORINDERIVAT
BE2/59617A BE892370A (en) 1981-10-06 1982-03-05 Alpha 2,3-di:oxo-piperazino-carbonyl-amino phenyl-acetamido-penicillin - and corresp. 3-1-methyl-tetrazolyl-thiomethyl cephalosporin(s) prepn. using tri:methyl-chloro-silane activated di:oxo piperazine
AU82675/82A AU8267582A (en) 1981-10-06 1982-04-16 Process of producing beta-lactam antibiotics
ES511709A ES8307816A1 (en) 1981-10-06 1982-04-26 Alpha 2,3-di:oxo-piperazino-carbonyl-amino phenyl-acetamido-penicillin - and corresp. 3-1-methyl-tetrazolyl-thiomethyl cephalosporin(s) prepn. using tri:methyl-chloro-silane activated di:oxo piperazine
IN502/CAL/82A IN155630B (en) 1981-10-06 1982-05-05
NO822870A NO822870L (en) 1981-10-06 1982-08-24 PROCESS FOR THE PRODUCTION OF PENICILLIN AND CEPHALOSPORIN DERIVATIVES
DK435682A DK435682A (en) 1981-10-06 1982-10-01 PROCEDURE FOR PENICILLIN AND CEPHALOSPORINE DERIVATIVES
IT68169/82A IT1157064B (en) 1981-10-06 1982-10-05 PROCEDURE FOR THE PRODUCTION OF PENICILLIN AND CEPHALOSPORIN DERIVATIVES
ES521036A ES521036A0 (en) 1981-10-06 1983-03-28 NEW PROCEDURE FOR THE OBTAINING OF D - (-) - ALPHA- (4-ALKYL-2,3-GOD-PIPERACINACARBONYLIC) -PHENYL (OR PARA-HYDROXYPHENIC).
ES521035A ES521035A0 (en) 1981-10-06 1983-03-28 A NEW PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF PENICILLIN AND CEPHALOSPORIN.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019810003767A KR830001969B1 (en) 1981-10-06 1981-10-06 6- ｛D-(-) α- (4-ethyl-2.3-dioxo-1 piperazinocarbonylamino) phenyl (or hydroxyphenyl) acetamido peniclanic acid and a method for preparing the salt thereof

Publications (2)

Publication Number Publication Date
KR830001969B1 KR830001969B1 (en) 1983-09-29
KR830007675A true KR830007675A (en) 1983-11-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003767A KR830001969B1 (en) 1981-10-06 1981-10-06 6- ｛D-(-) α- (4-ethyl-2.3-dioxo-1 piperazinocarbonylamino) phenyl (or hydroxyphenyl) acetamido peniclanic acid and a method for preparing the salt thereof

Country Status (3)

Country Link
JP (1) JPS5867694A (en)
KR (1) KR830001969B1 (en)
BE (1) BE892370A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282955B1 (en) * 1996-05-03 1998-04-02 Abres Associated Biotechnology PROCESS FOR THE PREPARATION OF UREIDE DERIVATIVES AND SYNTHETIC INTERMEDIATEs
IT1283530B1 (en) * 1996-07-26 1998-04-21 Ribbon Srl PROCEDURE FOR THE PREPARATION OF PENICILLINS
KR20090104855A (en) * 2007-01-31 2009-10-06 토야마 케미칼 컴퍼니 리미티드 New determination of sodium piperacillin

Also Published As

Publication number Publication date
BE892370A (en) 1982-07-01
JPS5867694A (en) 1983-04-22
KR830001969B1 (en) 1983-09-29

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