KR20220023985A

KR20220023985A - 효율적인 피피알 단백질의 작제방법 및 그의 이용

Info

Publication number: KR20220023985A
Application number: KR1020217040377A
Authority: KR
Inventors: 유스케 야지; 타카히로 나카무라
Original assignee: 에딧포스 인코포레이티드; 고쿠리쓰다이가쿠호진 규슈다이가쿠
Priority date: 2019-05-29
Filing date: 2020-05-29
Publication date: 2022-03-03
Also published as: CN114729017A; CA3142299A1; AU2020283177A1; JP7491515B2; IL288426A; JPWO2020241876A1; JP2023145672A; EP3978513A4; BR112021023878A2; SG11202113055UA; WO2020241876A1; US20220289795A1; EP3978513A1

Abstract

　고성능의 PPR 단백질을 제공한다. 기존의 7개 내지 14개보다 더 많은 모티프를 연결함으로써, 긴 염기서열에 결합하는 PPR 단백질을 제공한다. 이하에 대표되는 PPR 모티프를 제공한다: (A-1) 서열번호 9 또는 서열번호 401의 서열로 구성되는 PPR 모티프, (C-1) 서열번호 10의 서열로 구성되는 PPR 모티프, (G-1) 서열번호 11의 서열로 구성되는 PPR 모티프, (U-1) 서열번호 12의 서열로 구성되는 PPR 모티프. 이들 모티프는 각각 순서대로 표적 염기서열 중의 아데닌, 시토신, 구아닌 및 우라실에 대한 PPR 모티프로서 유용하다.

Description

효율적인 피피알 단백질의 작제방법 및 그의 이용

본 발명은 표적 핵산에 결합 가능한 단백질을 이용하는 핵산 조작기술에 관한 것이다. 본 발명은 의료(창약지원, 치료), 농업(농수축산물의 생산, 육종), 화학(생물학적 물질의 생산) 등과 같은 폭넓은 분야에서 유용하다.

피피알(PPR) 단백질은 약 35개 아미노산으로 구성된 PPR 모티프의 반복을 포함하는 단백질로서, PPR 모티프 하나가 하나의 염기와 특이하게 결합할 수 있다. PPR 모티프 중 1번, 4번, (ii)번(다음 모티프 이전 끝으로 부터 두 번째) 아미노산의 조합에 따라, 아데닌, 시토신, 구아닌, 우라실(또는 티민) 중 어느 것에 결합하는가가 결정된다(참조: 특허문헌 1, 2).

PPR 모티프는 1개의 모티프가 1개의 염기를 인식하여 결합하기 때문에, 예를 들어 18개 염기 길이의 핵산에 서열 특이적으로 결합하는 PPR 단백질을 설계할 경우, 18개의 PPR 모티프가 서로 연결된다. 지금까지 7개 내지 14개의 PPR 모티프를 연결한 인공 PPR 단백질의 작제가 보고되었다(참조: 비특허문헌 1~6).

특허문헌 1: 국제공개 WO2013/058404 특허문헌 2: 국제공개 WO2014/175284

1. Coquille, S. et al. An Artificial PPR Scaffold for Programmable RNA Recognition. Nature Communications 5, Article number: 5729 (2014) 2. Shen, C. et al. Specific RNA Recognition by Designer Pentatricopeptide Repeat Protein. Molecular Plant 8, 667-670 (2015) 3. Shen, C. et al. Structural Basis for Specific single-stranded RNA Recognition by Designer Pentatricopeptide Repeat Proteins. Nature Communications, Volume 7, Article number: 11285 (2016) 4. Gully, B. S. et al. The Design and Structural Characterization of a Synthetic Pentatricopeptide Repeat Protein. Acta Cryst. D71, 196-208 (2015) 5. Miranda, R. G. et al. RNA-binding Specificity Landscapes of Designer Pentatricopeptide Repeat Proteins Elucidate Principles of PPR-RNA Interactions. Nucleic Acids Research, 46 (5), 2613-2623 (2018) 6. Yan, J. et al. Delineation of Pentatricopeptide Repeat Codes for Target RNA Prediction. Nucleic Acids Research, gkz 075 (2019)

세포 내에서 목적으로 하는 RNA 분자와 특이하게 결합하고 원하는 대로 조작하기 위해서는 고성능의 PPR 단백질이 요구된다.

또한, 세포 내에서 원하는 RNA 분자와 특이하게 결합하고 원하는 대로 조작하려면 기존의 7개 내지 14개보다 많은 모티프를 연결하여 긴 염기서열에 결합하는 PPR 단백질이 필요하다. 예를 들어, 인간게놈은 60억개의 염기가 있고 4개의 염기(A, C, G, T 또는 U)로 구성되어 있기 때문에, 그 게놈의 서열로부터 하나의 염기서열을 특정하기 위해서는 최소 17개의 염기서열이 필요하다(4¹⁶은 40억, 4¹⁷은 160억이기 때문이다).

본 발명은 신규한 PPR 모티프 등으로서 이하를 제공한다.

[1] 다음 중 어느 하나의 PPR 모티프:

(A-1) 서열번호 9의 서열로 구성되는 PPR 모티프, 또는 서열번호 9의 서열에있어서 10번 위치 아미노산의 티로신으로의 치환, 15번 위치 아미노산의 리신으로의 치환, 16번 위치 아미노산의 류신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 18번 위치 아미노산의 아스파라긴산으로의 치환, 및 28번 위치 아미노산의 글루탐산으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프,

또는 서열번호 401의 서열로 구성되는 PPR 모티프, 서열번호 401의 서열에 있어서 10번 위치 아미노산의 티로신으로의 치환, 16번 위치 아미노산의 류신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 18번 위치 아미노산의 아스파라긴산으로의 치환, 및 28번 위치 아미노산의 글루탐산으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프;

(A-2) 서열번호 9 또는 401의 서열에 있어서 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1 내지 20개가 치환, 결실 또는 부가된 서열로 이루어지고 아데닌 결합성인 PPR 모티프;

(A-3) 서열번호 9 또는 401의 서열과 최소한 42%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 아데닌 결합성인 PPR 모티프;

(C-1) 서열번호 10의 서열로 구성되는 PPR 모티프, 또는 서열번호 10의 서열에 있어서 2번 위치 아미노산의 세린으로의 치환, 5번 위치 아미노산의 이소류신으로의 치환, 7번 위치 아미노산의 이소류신으로의 치환, 8번 위치 아미노산의 리신으로의 치환, 10번 위치 아미노산의 페닐알라닌 또는 티로신으로의 치환, 15번 위치 아미노산의 아르기닌으로의 치환, 22번 위치 아미노산의 발린으로의 치환, 24번 위치 아미노산의 아르기닌으로의 치환, 27번 위치 아미노산의 아르기닌으로의 치환, 및 29번 위치 아미노산의 아르기닌으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프;

(C-2) 서열번호 10의 서열에 있어서 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 25개가 치환, 결실 또는 부가된 서열로 이루어지고 시토신 결합성인 PPR 모티프;

(C-3) 서열번호 10의 서열과 최소한 25%의 서열 동일성을 가지되, 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 시토신 결합성인 PPR 모티프;

(G-1) 서열번호 11의 서열로 구성되는 PPR 모티프, 또는 서열번호 11의 서열에 있어서 10번 위치 아미노산의 페닐알라닌으로의 치환, 15번 위치 아미노산의 아스파라긴산으로의 치환, 27번 위치 아미노산의 발린으로의 치환, 28번 위치 아미노산의 세린으로의 치환, 및 35번 위치 아미노산의 이소류신으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산으로 구성된 PPR 모티프;

(G-2) 서열번호 11의 서열에 있어서 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 2개가 치환, 결실 또는 부가된 서열로 이루어지고 구아닌 결합성인 PPR 모티프;

(G-3) 서열번호 11의 서열과 최소한 40%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 구아닌 결합성인 PPR 모티프;

(U-1) 서열번호 12의 서열로 구성되는 PPR 모티프, 또는 서열번호 12의 서열에 있어서 10번 위치 아미노산의 페닐알라닌으로의 치환, 13번 위치 아미노산의 세린으로의 치환, 15번 위치 아미노산의 리신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 20번 위치 아미노산의 류신으로의 치환, 21번 위치 아미노산의 리신으로의 치환, 23번 위치 아미노산의 페닐알라닌으로의 치환, 24번 위치 아미노산의 아스파라긴산으로의 치환, 27번 위치 아미노산의 리신으로의 치환, 28번 위치 아미노산의 리신으로의 치환, 29번 위치 아미노산의 아르기닌으로의 치환 및 31번 위치 아미노산의 류신으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프;

(U-2) 서열번호 12의 서열에 있어서 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 22개가 치환, 결실 또는 부가된 서열로 이루어지고 우라실 결합성인 PPR 모티프;

(U-3) 서열번호 12의 서열과 최소한 37%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산은 동일하고 우라실 결합성인 PPR 모티프.

[2] [1]에 기재된 PPR 모티프의, 표적 RNA가 15개의 염기 길이 이상인 PPR 단백질의 작제를 위한 용도.

[3] [1]에 기재된 PPR 모티프의 PPR 단백질 작제를 위한 용도에 있어서, PPR 단백질의 표적 RNA에 대한 결합능력을 높이기 위한 것을 특징으로 하는 용도.

[4] n개의 염기서열로 이루어진 표적 RNA에 결합 가능한 n개의 PPR 모티프를 포함하는 단백질로서,

해당 염기서열 중의 아데닌에 대한 PPR 모티프가 [1]에 정의된 (A-1), (A-2), 또는 (A-3)의 PPR 모티프이고;

해당 염기서열 중의 시토신에 대한 PPR 모티프가 [1]에 정의된 (C-1), (C-2), 또는 (C-3)의 PPR 모티프이며;

해당 염기서열 중의 구아닌에 대한 PPR 모티프가 [1]에 정의된 (G-1), (G-2), 또는 (G-3)의 PPR 모티프이고;

해당 염기서열 중의 우라실에 대한 PPR 모티프가 [1]에 정의된 (U-1), (U-2), 또는 (U-3)의 PPR 모티프인 PPR 단백질.

[5] n이 15 이상인 [4]에 기재된 단백질.

[6] N-말단에서 1번째 PPR 모티프가 다음 중 어느 하나인, [4] 또는 [5]에 기재된 단백질:

(1st_A-1) 서열번호 402의 서열에 있어서 6번 및 9번 위치의 아미노산이 이하에 정의된 조합의 어느 하나를 만족하도록 치환된 PPR 모티프;

(1st_A-2) (1st_A-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 아데닌 결합성인 PPR 모티프;

(1st_A-3) (1st_A-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 아데닌 결합성인 PPR 모티프;

(1st_C-1) 서열번호 403의 서열로 구성되는 PPR 모티프;

(1st_C-2) (1st_C-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 시토신 결합성인 PPR 모티프;

(1st_C-3) (1st_C-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 시토신 결합성인 PPR 모티프;

(1st_G-1) 서열번호 404의 서열에 있어서 6번 및 9번 위치의 아미노산이 이하에 정의된 조합 중 어느 하나를 만족하도록 치환된 서열로 구성되는 PPR 모티프;

(1st_G-2) (1st_G-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 구아닌 결합성인 PPR 모티프;

(1st_G-3) (1st_G-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 구아닌 결합성인 PPR 모티프;

(1st_U-1) 서열번호 405의 서열에 있어서 6번 및 9번 위치의 아미노산이 이하에 정의된 조합의 어느 하나를 만족하도록 치환된 서열로 구성되는 PPR 모티프;

(1st_U-2)(1st_U-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 우라실 결합성인 PPR 모티프;

(1st_U-3) (1st_U-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 우라실 결합성인 PPR 모티프

·6번 위치의 아미노산이 아스파라긴이고, 9번 위치의 아미노산이 글루탐산인 조합

·6번 위치의 아미노산이 아스파라긴이고, 9번 위치의 아미노산이 글루타민인 조합

·6번 위치의 아미노산이 아스파라긴이고, 9번 위치의 아미노산이 리신인 조합

·6번 위치의 아미노산 아스파라긴산이고, 9번 위치의 아미노산이 글리신인 조합.

[7] [4] 내지 [6]의 어느 하나에 기재된 단백질을 이용하는 것을 특징으로 하는 RNA 접합의 제어방법.

[8] [4] 내지 [6]의 어느 하나에 기재된 단백질을 이용하는 것을 특징으로 하는 RNA의 검출방법.

[9] 형광 단백질, 핵이행 신호 펩티드 및 태그 단백질로 이루어진 군으로부터 선택되는 적어도 하나와 [4] 내지 [6]의 어느 하나에 기재된 단백질과의 융합 단백질.

[10] [1]에 기재된 PPR 모티프, 또는 [4] 내지 [6]의 어느 하나에 기재된 단백질을 암호화하는 핵산.

[11] [10]에 기재된 핵산을 포함하는 벡터.

[12] [11]에 기재된 벡터를 포함하는 세포(인간 개체는 제외).

[13] [1]에 기재된 PPR 모티프, [4] 내지 [6]의 어느 하나에 기재된 단백질, 또는 [11]에 기재된 벡터를 이용하는 것을 특징으로 하는 RNA의 조작방법(인간 개체에서의 실시를 제외한다).

[14] [13]에 기재된 조작방법을 포함하는 것을 특징으로 하는 생물의 생산방법.

[1] 이하 중 어느 하나의 PPR 모티프:

(A-1) 서열번호 9의 서열로 구성되는 PPR 모티프, 또는 서열번호 9의 서열에 있어서 10번 위치 아미노산의 티로신으로의 치환, 15번 위치 아미노산의 리신으로의 치환, 16번 위치 아미노산의 류신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 18번 위치 아미노산의 아스파라긴산으로의 치환, 및 28번 위치 아미노산의 글루탐산으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산으로 이루어진 PPR 모티프;

(A-2) 서열번호 9의 서열에 있어서 1, 2, 3, 4, 6, 7, 9, 11, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 20개가 치환, 결실 또는 부가된 서열로 이루어지고 아데닌 결합성인 PPR 모티프;

(A-3) 서열번호 9의 서열과 최소한 42%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 아데닌 결합성인 PPR 모티프;

(C-1) 서열번호 10의 서열로 구성되는 PPR 모티프, 또는 서열번호 10의 서열에서 2번 위치 아미노산의 세린으로의 치환, 5번 위치 아미노산의 이소류신으로의 치환, 7번 위치 아미노산의 이소류신으로의 치환, 8번 위치 아미노산의 리신으로의 치환, 10번 위치 아미노산의 페닐알라닌 또는 티로신으로의 치환, 15번 위치 아미노산의 아르기닌으로의 치환, 22번 위치 아미노산의 발린으로의 치환, 24번 위치 아미노산의 아르기닌으로의 치환, 27번 위치 아미노산의 류신으로의 치환, 및 29번 위치 아미노산의 아르기닌으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산으로 이루어진 PPR 모티프;

(G-1) 서열번호 11의 서열로 구성되는 PPR 모티프, 또는 서열번호 11의 서열에 있어서 10번 위치 아미노산의 페닐알라닌으로의 치환, 15번 위치 아미노산의 아스파라긴산으로의 치환, 27번 위치 아미노산의 발린으로의 치환, 28번 위치 아미노산의 세린으로의 치환, 및 35번 위치 아미노산의 이소류신으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산으로 이루어진 PPR 모티프;

(G-2) 서열번호 11의 서열에 있어서 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 21개가 치환, 결실 또는 부가된 서열로 이루어지고 구아닌 결합성인 PPR 모티프;

(U-1) 서열번호 12의 서열로 구성되는 PPR 모티프, 또는 서열번호 12의 서열에 있어서 10번 위치 아미노산의 페닐알라닌으로의 치환, 13번 위치 아미노산의 세린으로의 치환, 15번 위치 아미노산의 리신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 20번 위치 아미노산의 류신으로의 치환, 21번 위치 아미노산의 리신으로의 치환, 23번 위치 아미노산의 페닐알라닌으로의 치환, 24번 위치 아미노산의 아스파라긴산으로의 치환, 27번 위치 아미노산의 리신으로의 치환, 28번 위치 아미노산의 리신으로의 치환, 29번 위치 아미노산의 아르기닌으로의 치환, 및 31번 위치 아미노산의 류신으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산으로 이루어진 PPR 모티프;

(U-3) 서열번호 12의 서열과 최소 37%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34의 아미노산은 동일하고 우라실 결합성인 PPR 모티프.

[2] [1]에 기재된 PPR 모티프의, 표적 RNA가 15개 염기 길이 이상인 PPR 단백질 작제를 위한 용도.

해당 염기서열 중 아데닌에 대한 PPR 모티프가 [1]에 정의된 (A-1), (A-2), 또는 (A-3)의 PPR 모티프이고;

해당 염기서열 중 시토신에 대한 PPR 모티프가 [1]에 정의된 (C-1), (C-2) 또는 (C-3)의 PPR 모티프이며;

해당 염기서열 중 구아닌에 대한 PPR 모티프가 [1]에 정의된 (G-1), (G-2), 또는 (G-3)의 PPR 모티프이고;

해당 염기서열 중 우라실에 대한 PPR 모티프가 [1]에 정의된 (U-1), (U-2) 또는 (U-3)의 PPR 모티프인 PPR 단백질.

[5] n이 15 이상인 [4]에 기재된 단백질.

[6] [4] 또는 [5]에 기재된 단백질을 이용하는 것을 특징으로 하는 RNA 접합(splicing)의 제어방법.

[7] [4] 또는 [5]에 기재된 단백질을 이용하는 것을 특징으로 하는 RNA 검출방법.

[8] 형광 단백질, 핵이행 신호 펩티드 및 태그 단백질로 이루어진 군으로부터 선택되는 적어도 하나와 [4] 또는 [5]에 기재된 단백질과의 융합 단백질.

[9] [1]에 기재된 PPR 모티프, 또는 [4] 또는 [5]에 기재된 단백질을 암호화하는 핵산.

[10] [9]에 기재된 핵산을 포함하는 벡터.

[11] [10]에 기재된 벡터를 포함하는 세포(인간 개체는 제외).

[12] [1]에 기재된 PPR 모티프, [4] 또는 [5]에 기재된 단백질, 또는 [10]에 기재된 벡터를 이용하는 RNA의 조작방법(인간 개체에서의 실시는 제외한다).

[13] [12]에 기재된 조작방법을 포함하는 것을 특징으로 하는 생물의 생산방법.

[14] 이하의 공정을 포함하는 n개의 염기서열로 이루어진 표적 핵산에 결합 가능한, n개의 PPR 모티프를 포함하는 단백질을 암호화하는 유전자의 작제방법:

아데닌, 시토신, 구아닌, 또는 우라실 또는 티민에 결합하는 PPR 모티프 각각을 암호화하는 4종, 및 PPR 모티프의 2개 연결물(linkage product) 각각을 암호화하는 16종을 포함하는, 최소한 20종의 폴리뉴클레오티드가 최소한 m 종의 순서로 연결 가능하도록 설계된 중간 벡터 Dest-a...의 각각에 삽입된, 최소한 20×m 종의 PPR 파트의 라이브러리로부터 목적하는 유전자를 작제하기 위해 필요한 m개의 PPR 파트를 선택하는 공정; 및,

선택한 m 종의 PPR 파트를 벡터 파트와 함께 Golden Gate 반응을 수행하여 m개의 폴리뉴클레오티드 연결물(polynucleotide linkage)이 삽입된 벡터를 수득하는 공정(단, n은 m 이상이고, m X 2 이하이다).

[15] m이 10이고, 15개 이상의 PPR 모티프를 포함하는 단백질을 암호화하는 유전자를 작제하기 위한 [14]에 기재된 작제방법.

[16] 고상화된 표적 핵산에 후보 단백질을 포함하는 용액을 제공하여 표적 핵산에 결합하는 단백질을 검출 또는 정량하는 공정을 포함하는, n개의 염기서열로 이루어진 표적 핵산에 결합 가능한 n개의 PPR 모티프를 포함하는 단백질을 검출 또는 정량하는 방법.

[17] 후보 단백질이 표지 단백질과 융합된 [16]에 기재된 방법.

도 1은 v2 모티프(아데닌 인식)를 나타낸다.
도 2는 v2 모티프(시토신 인식)를 나타낸다.
도 3은 v2 모티프(구아닌 인식)를 나타낸다.
도 4는 v2 모티프(우라실 인식)를 나타낸다.
도 5는 PPR 모티프 서열을 매끄럽게(seamlessly) 연결하는 클로닝 방법의 예를 나타낸다.
도 6은 1개의 모티프 또는 2개의 모티프를 포함하는 라이브러리를 이용한 심리스(seamless) 클로닝의 검증결과를 나타낸다.
A: v1 모티프, v2 모티프, v3.1 모티프 및 v3.2 모티프의 아미노산 서열을 나타낸다. v3.1은 v2에서 아데닌 인식 모티프로 D15K 변이를 도입한 것이고, v3.2는 1번째 모티프는 1st_x를 선택하고 2번째 모티프 이후는 v2_C, v2_G, v2_U, v3.1_A 중에서 선택한다.
B: 18개 모티프 PPR 단백질의 각 3종을 3클론 작제하였을 때의 결과를 나타낸다. v1에서는 PPR2의 2번째 클론 이외에는 올바른 크기의 밴드를 얻을 수 있었고, v2에서는 모든 클론에서 올바른 크기의 밴드를 얻을 수 있었다.
도 7은 고속 대량으로(high throughput) PPR 단백질의 결합능력을 평가하는 방법의 예를 나타낸다.
A: 대표적인 핵산-단백질 결합의 실험계획을 비교한 것이다.
B: RPB-ELISA(RNA-protein binding ELISA)법의 개략을 나타낸다.
C: MS2 단백질과 그 표적 RNA를 사용하였을 경우의 실험결과를 나타낸다.
정제된 단백질 용액("Purified protein"), 대장균 용균체("Lysate") 모두 특이한 결합이 검출되었다.
도 8은 RNA 결합능력 비교실험 결과를 나타낸다.
모티프 서열 v2로 작제한 경우, 모티프 서열 v1으로 작제한 것과 비교하여 모두 표적서열과의 결합력의 증가(1.3배 내지 3.6배)를 볼 수 있었다. 또한, v2가 v1보다 모두 표적(target) 결합 신호/비표적(non-target) 결합 신호(S/N)이 더 높음에 따라, v2가 v1보다 친화성도 높고 표적에 대한 특이성이 높은 것으로 나타났다.
좌상단 그래프(binding signal (L.U./10⁷ CPU))에서 검정색은 표적서열을 가지는 RNA 프로브, 회색은 Off target 1을 가지는 RNA 프로브, 흰색은 Off target 2를 가지는 RNA 프로브 각각에 대한 결과를 나타낸다.
좌하단에 보여지는 프로브 서열("Probe seq.")의 밑줄은 표적서열("Target seq.")이다.
도 9는 PPR 단백질의 RNA 결합능력 상세 분석(특이성) 결과를 나타낸다.
V2 모티프를 이용하여 23종의 표적서열에 대한 PPR 단백질을 작제하고 RPB-ELISA법을 이용하여 모든 결합의 조합(binding combination)을 분석하였다. 21종의 PPR 단백질이 표적에 대한 결합력이 가장 강한 것으로 나타났다(위). 마찬가지로, V3.1 모티프를 사용하여 RNA 결합능력을 분석하였다(아래).
도 10은 PPR 단백질의 RNA 결합능력 상세 분석(친화성) 결과를 나타낸다.
A: 작제된 단백질의 표적에 대한 Kd 값을 나타낸다. 최소치는 1.95 x 10^-9이며, 지금까지 보고된 디자인 PPR 단백질 중 Kd 값이 가장 낮았다.
B: Kd 값과 RPB-ELISA에서의 결합실험으로 얻은 신호 값과의 상관관계를 나타내는 그래프이다. RPB-ELISA 에서의 발광치가 1.0 내지 2.0 x 10⁷ 인 경우, Kd 값은 10^-6내지10^-7 M, RPB-ELISA 에서의 발광치가 2.0 내지 4.0 x 10⁷ 인 경우, Kd 값은 10^-7 내지10^-8 M, RPB-ELISA 에서의 발광치가 4.0 x 10⁷ 보다 큰 경우, Kd 값이 ~10^-8이하인 것으로추정할 수 있다.
도 11은 구축 성공확률(construction probability)을 나타내는 그래프이다.
72종의 표적서열에 대한 PPR 단백질을 v2 모티프를 이용하여 작제하고, RPB-ELISA법을 이용하여 구축 성공확률을 산출하였다. 72개의 PPR 단백질 중 Kd 값이 10^-6 M 이하인(RPB-ELISA 값이 1 x 10⁷ 이상) 것으로 추정되는 것은 63개(88%)였다. 또한, 표적 결합 신호를 비표적 결합 신호로 나눈 값으로서 특이성을 평가하는 값(S/N)이 10보다 높은 것은 54개(75%)였다. 이러한 점에서 v2 모티프를 사용하여 PPR 단백질을 작제함으로써, 효율적으로 서열 특이한 RNA 결합 단백질을 작제할 수 있음을 알 수 있었다.
도 12는 PPR 모티프 수에 관련된 표적결합 활성평가 결과를 나타낸다.
A: 각 표적서열별 결과를 나타낸다.
B: 18개 모티프, 15개 모티프, 12개 모티프 각각의 값의 평균값을 나타낸다.
모티프 수가 많을수록 결합강도가 높아지고, 18개의 모티프와 15개의 모티프를 비교하면, 18개의 모티프가 더 높은 결합강도를 가지는 단백질이 안정적으로 작제될 수 있음을 알 수 있었다.
도 13은 PPR 단백질에 의한 인위적인 접합 제어의 예를 나타낸다
A: 실험계획: 인트론 1, 엑손 2, 인트론 2의 영역 중 18개 염기의 서열을 선택하고, 이들에 결합하는 PPR 단백질에 의해 RG-6 리포터의 접합변이(splicing variant) 양의 비율을 변화시킬 수 있는지를 실험하였다.
B: PPR 발현 플라스미드 DNA와 RG-6 리포터 플라스미드 DNA를 혼합하여 배양한 후 세포의 GFP 형광 및 RFP 형광 이미지를 나타낸다.
C: 접합변이(splicing variant) 비율. 형광화상 촬영 후 세포에서 총세포 RNA를 추출하여 RT-PCR에 의한 증폭산물을 전기영동하였다. 114bp 부근의 밴드를 엑손 스킵으로 인해 생긴 PCR 산물(a), 142bp 부근의 밴드를 스킵하지 않은 PCR 산물(b)로 하여 각각의 밴드강도를 측정하였다. 접합 비율은 a/(a+b)에 의해 산출하였다. 접합 비율은 PPR을 도입할 경우 크게 변화하는 것으로 나타났다. PPR 단백질을 이용함으로써 엑손 스키핑(exon skipping)을 변화시킬 수 있음이 증명되었으며, v2 모티프를 이용함으로써 더욱 효율적으로 접합을 변화시킬 수 있음이 밝혀졌다.
도 14는 N-말단 측으로부터 1번째 PPR 모티프가 응집에 미치는 영향을 나타내는 그래프이다.
각각의 PPR 단백질을 대장균 발현계에서 제조하여 정제하고, 겔 여과 크로마토그래피로 분리하였다. 용출분획(Elution vol.)이 적을수록 분자 크기가 크다. v2에서는 8mL 내지 10mL의 용출분획에서 용출된 반면, v3.2에서는 12mL 내지 14mL의 용출분획에서 피크가 나타났다. 결과적으로, v2에서는 단백질의 크기가 커지고 있다는 점에서 응집하고 있을 가능성이 시사되며, 그 응집은 v3.2에서 개선되고 있음을 알 수 있었다.

[PPR 모티프, PPR 단백질]

(정의)

본 발명에서는 'PPR 모티프'는 특히 기재한 경우를 제외하고 Web 상의 단백질 도메인 검색 프로그램에서 아미노산 서열을 분석하였을 때, Pfam에서 PF01535, Prosite에서 PS51375로 얻을 수 있는 E 값이 소정값 이하(바람직하게는 E-03)의 아미노산 서열을 갖는 30개 내지 38개 아미노산으로 구성되는 폴리펩티드를 의미한다. 본 발명에서 정의하는 PPR 모티프를 구성하는 아미노산의 위치번호는 PF01535와 거의 같은 의미이며, PS51375의 아미노산 위치에서 2를 뺀 수(예; 본 발명의 1번→PS51375의 3번)에 상당한다. 단, 'ii'(-2)번 아미노산이라고 할 때는 PPR 모티프를 구성하는 아미노산 뒤(C 말단 쪽)에서 2번째 아미노산, 또는 다음 PPR 모티프의 1번째 아미노산에 대해 2개 N-말단 쪽, 즉 -2번째 아미노산을 의미한다. 다음의 PPR 모티프가 명확하게 동정되지 않는 경우, 다음 헬릭스 구조의 1번째 아미노산에 대하여 2개 이전의 아미노산을 'ii'라 한다. Pfam에 대해서는 http://pfam. Sanger.ac.uk/, Prosite 에 대해서는, http://www.expasy.org/prosite/ 를 참조할 수 있다.

PPR 모티프의 보존 아미노산 서열은, 아미노산 수준에서의 보존성은 낮지만, 2차 구조상으로 2개의 α-헬릭스는 잘 보존되어 있다. 전형적인 PPR 모티프는 35개 아미노산으로 구성되는데, 그 길이는 30개 내지 38개 아미노산과 가변적이다.

보다 구체적으로, 본 발명의 PPR 모티프는 하기 일반식(1)로 나타내는 30개 내지 38개 아미노산 길이의 폴리펩티드로 이루어진다.

..... (1)

상기 일반식(1)에서,

　Helix A는 12개 아미노산 길이의 α-헬릭스 구조를 형성할 수 있는 부분으로 하기 일반식(2)로 나타내고,

..... (2)

　(상기 일반식(2)에서, A₁ ~ A₁₂는 각각 독립적으로 아미노산을 나타낸다)

　 X는 존재하지 않거나 1개 내지 9개 아미노산 길이로 구성되며;

　 Helix B는 11개 내지 13개 아미노산 길이로 이루어진 α-헬릭스 구조를 형성할 수 있는 부분이고;

L은 2개 내지 7개 아미노산 길이의, 하기 일반식(3)으로 나타내는 부분이다.

..... (3)

(상기 일반식(3)에서, 각 아미노산은 'i'(-1), 'ii'(-2) 등으로 C 말단 측으로부터 넘버링되고, L_iii 내지 L_vii는 존재하지 않을 수도 있다)

본 명세서에서 'PPR 단백질'이라 함은, 특별히 기재한 경우를 제외하고 상술한 PPR 모티프를 1개 이상, 바람직하게는 2개 이상 갖는 PPR 단백질을 의미한다. 본 명세서에서 '단백질'이라 함은, 특별히 기재한 경우를 제외하고 폴리펩티드(복수의 아미노산이 펩티드 결합한 사슬)로 이루어진 물질을 의미하고, 비교적 저분자인 폴리펩티드로 이루어진 것도 포함된다. 본 발명에서 '아미노산'이라 함은, 통상의 아미노산 분자를 의미하고, 펩티드 사슬을 구성하고 있는 아미노산 잔기를 의미하는 경우도 있다. 어느 쪽을 의미하는지는 문맥상 당업자에게 명백하다.

본 발명에서 PPR 모티프의 표적 핵산에서의 염기와의 결합성에 관하여 '특이성(specificity)/특이적(specific)'이라 함은, 특별히 기재한 경우를 제외하고 4 종의 염기 중 어느 하나의 염기에 대한 결합활성이 다른 염기에 대한 결합활성보다 높은 것을 의미한다.

본 발명에서는 '핵산'이라 함은 RNA 또는 DNA를 의미한다. 또한, PPR 단백질은 RNA 또는 DNA 중의 염기에 대하여 특이성을 가질 수 있으나, 핵산 단량체에 결합하지는 않는다.

PPR 모티프는 1, 4, (ii)번 위치의 3가지 아미노산 조합이 염기와의 특이한 결합을 위해 중요하며, 이들의 조합에 의해 결합하는 염기가 어느 것인지 결정할 수 있다(참조: 특허문헌 1, 2).

구체적으로, RNA 결합성의 PPR 모티프에 관해서는, 1번, 4번, (ii)번 위치의 3가지 아미노산의 조합과 결합이 가능한 염기의 관계는 다음과 같다(참조: 특허문헌 1):

(3-1) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 발린, 아스파라긴 및 아스파라긴산의 경우, 그 PPR 모티프는 U에 강하게 결합하고 다음으로 C에, 그 다음에 A 또는 G에 대하여 결합하는 선택적인 RNA 염기 결합능력을 가진다.

(3-2) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 발린, 트레오닌, 아스파라긴의 경우, 그 PPR 모티프는 A에 강하게 결합하고 다음으로 G에, 그 다음에 C에 대해 결합하나 U에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-3) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 발린, 아스파라긴, 아스파라긴의 경우, 그 PPR 모티프는 C에 강하게 결합하고 다음으로 A 또는 U에 대하여 결합하나 G에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-4) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 글루탐산, 글리신, 아스파라긴산의 경우, 그 PPR 모티프는 G에 강하게 결합하나 A, U 및 C에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-5) A₁, A₄ 및 L_ii의 3가지 아미노산 조합이 순서대로 이소류신, 아스파라긴, 아스파라긴의 경우, 그 PPR 모티프는 C에 강하게 결합하고 다음 U에, 그 다음 A에 대해 결합하나 G에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-6) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 발린, 트레오닌, 아스파라긴산의 경우, 그 PPR 모티프는 G에 강하게 결합하고 다음에 U에 대하여 결합하나 A와 C에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-7) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 리신, 트레오닌, 아스파라긴산의 경우, 그 PPR 모티프는 G에 강하게 결합하고 다음에 A에 대해 결합하나 U 및 C에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-8) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 페닐알라닌, 셀린, 아스파라긴의 경우, 그 PPR 모티프는 A에 강하게 결합하고 다음으로 C에, 그 다음으로 G 및 U에 대하여 결합하는 선택적인 RNA 염기결합능력을 가진다.

(3-9) A₁, A₄ 및 L_ii의 3가지 아미노산 조합이 순서대로 바린, 아스파라긴, 셀린의 경우, 그 PPR 모티프는 C에 강하게 결합하고 다음에 U에 대해 결합하나 A 및 G에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-10) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 페닐알라닌, 트레오닌, 아스파라긴의 경우, 그 PPR 모티프는 A에 강하게 결합하나 G, U 및 C에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-11) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 이소류신, 아스파라긴, 아스파라긴산의 경우, 그 PPR 모티프는 U에 강하게 결합하고 다음에 A에 대해 결합하나 G 및 C에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-12) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 트레오닌, 트레오닌, 아스파라긴의 경우, 그 PPR 모티프는 A에 강하게 결합하나 G, U 및 C에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-13) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 이소류신, 메티오닌, 아스파라긴산의 경우, 그 PPR 모티프는 U에 강하게 결합하고 다음에 C에 대해 결합하나 A 및 G에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-14) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 페닐알라닌, 프롤린, 아스파라긴산의 경우, 그 PPR 모티프는 U에 강하게 결합하고 다음에 C에 대하여 결합하나 A 및 G에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-15) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 티로신, 프롤린, 아스파라긴산의 경우, 그 PPR 모티프는 U에 강하게 결합하나 A, G 및 C에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

(3-16) A₁, A₄ 및 L_ii의 3가지 아미노산의 조합이 순서대로 류신, 트레오닌, 아스파라긴산의 경우, 그 PPR 모티프는 G에 강하게 결합하나 A, U 및 C에는 결합하지 않는 선택적인 RNA 염기결합능력을 가진다.

구체적으로, DNA 결합성의 PPR 모티프에 관하여 1번, 4번, (ii)번 위치의 3가지 아미노산의 조합과 결합 가능한 염기의 관계는 다음과 같다(참조: 특허문헌):

(2-1) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 글리신, 아스파라긴산인 경우, 그 PPR 모티프는 G에 선택적으로 결합하고;

(2-2) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 글루탐산, 글리신, 아스파라긴산인 경우, 그 PPR 모티프는 G에 선택적으로 결합하며;

(2-3) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 글리신, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하고;

(2-4) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 글루탐산, 글리신, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하며;

(2-5) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 글리신, 세린인 경우, 그 PPR 모티프는 A에 선택적으로 결합하고, 다음으로 C에 결합하고;

(2-6) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 이소류신, 임의의 아미노산인 경우, 그 PPR 모티프는 T 및 C에 선택적으로 결합하며;

(2-7) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 이소류신, 아스파라긴인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고, 다음으로 C에 결합하고;

(2-8) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 류신, 임의의 아미노산인 경우, 그 PPR 모티프는 T 및 C에 선택적으로 결합하며;

(2-9) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 류신, 아스파라긴산인 경우, 그 PPR 모티프는 C에 선택적으로 결합하고;

(2-10) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 류신, 리신인 경우, 그 PPR 모티프는 T에 선택적으로 결합하며;

(2-11) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 메티오닌, 임의의 아미노산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고;

(2-12) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 메티오닌, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하며;

(2-13) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 이소류신, 메티오닌, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고, 다음으로 C에 결합하고;

(2-14) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 아스파라긴, 임의의 아미노산인 경우, 그 PPR 모티프는 C 및 T에 선택적으로 결합하며;

(2-15) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 아스파라긴, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고;

(2-16) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 페닐알라닌, 아스파라긴, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하며;

(2-17) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 글리신, 아스파라긴, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고;

(2-18) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 이소류신, 아스파라긴, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하며;

(2-19) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 트레오닌, 아스파라긴, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고;

(2-20) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 발린, 아스파라긴, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고, 다음으로 C에 결합하며;

(2-21) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 티로신, 아스파라긴, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고, 다음으로 C에 결합하고;

(2-22) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 아스파라긴, 아스파라긴인 경우, 그 PPR 모티프는 C에 선택적으로 결합하며;

(2-23) A₁, A₄ 및 L_ii 3개 아미노산이 순서대로 이소류신, 아스파라긴, 아스파라긴인 경우, 그 PPR 모티프는 C에 선택적으로 결합하고;

(2-24) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 세린, 아스파라긴, 아스파라긴인 경우, 그 PPR 모티프는 C에 선택적으로 결합하며;

(2-25) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 발린, 아스파라긴, 아스파라긴인 경우, 그 PPR 모티프는 C에 선택적으로 결합하고;

(2-26) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 아스파라긴, 세린인 경우, 그 PPR 모티프는 C에 선택적으로 결합하며;

(2-27) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 발린, 아스파라긴, 세린인 경우, 그 PPR 모티프는 C에 선택적으로 결합하고;

(2-28) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 아스파라긴, 트레오닌인 경우, 그 PPR 모티프는 C에 선택적으로 결합하며;

(2-29) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 발린, 아스파라긴, 트레오닌인 경우, 그 PPR 모티프는 C에 선택적으로 결합하고;

(2-30) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 아스파라긴, 트립토판인 경우, 그 PPR 모티프는 C에 선택적으로 결합하고, 다음으로 T에 결합하며;

(2-31) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 이소류신, 아스파라긴, 트립토판인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고, 다음으로 C에 결합하고;

(2-32) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 프롤린, 임의의 아미노산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하며;

(2-33) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 프롤린, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고;

(2-34) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 페닐알라닌, 프롤린, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하며;

(2-35) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 티로신, 프롤린, 아스파라긴산인 경우, 그 PPR 모티프는 T에 선택적으로 결합하고;

(2-36) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 세린, 임의의 아미노산인 경우, 그 PPR 모티프는 A 및 G에 선택적으로 결합하며;

(2-37) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 세린, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하고;

(2-38) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 페닐알라닌, 세린, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하며;

(2-39) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 발린, 세린, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하고;

(2-40) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 트레오닌, 임의의 아미노산인 경우, 그 PPR 모티프는 A와 G에 선택적으로 결합하며;

(2-41) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 트레오닌, 아스파라긴산인 경우, 그 PPR 모티프는 G에 선택적으로 결합하고;

(2-42) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 발린, 트레오닌, 아스파라긴산인 경우, 그 PPR 모티프는 G에 선택적으로 결합하며;

(2-43) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 트레오닌, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하고;

(2-44) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 페닐알라닌, 트레오닌, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하며;

(2-45) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 이소류신, 트레오닌, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하고;

(2-46) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 발린, 트레오닌, 아스파라긴인 경우, 그 PPR 모티프는 A에 선택적으로 결합하며;

(2-47) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 발린, 임의의 아미노산인 경우, 그 PPR 모티프는 A, C 및 T에 결합하지만 G는 결합하지 않고;

(2-48) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 이소류신, 발린, 아스파라긴산인 경우, 그 PPR 모티프는 C에 선택적으로 결합하고, 다음으로 A에 결합하며;

(2-49) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 발린, 글리신인 경우, 그 PPR 모티프는 C에 선택적으로 결합하고; 및,

(2-50) A₁, A₄ 및 L_ii의 3개 아미노산이 순서대로 임의의 아미노산, 발린, 트레오닌인 경우, 그 PPR 모티프는 T에 선택적으로 결합한다.

(신규한 PPR 모티프)

본 발명은 신규한 PPR 모티프를 제공한다.

본 발명에 의해 제공되는 신규한 PPR 모티프로서, 아데닌 결합성(adenine-binding property)인 것은 이하의 (A-1), (A-2) 및 (A-3)이다:

(A-3) 서열번호 9의 서열과 최소한 42%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 아데닌 결합성인 PPR 모티프.

(A-1)에서의 치환은 1개라도 좋고, 2개 이상이라도 좋으며, 또한 상기 모두이어도 무방하다.

(A-2)에서 서열번호 9의 서열에서 치환 등이 될 수 있는 아미노산인, 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 20개는

바람직하게는 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산으로서, 5, 8, 13, 21, 22, 23, 25, 29, 35번 위치 아미노산 이외의 아미노산 1개 내지 11개이고,

보다 바람직하게는 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산으로서, 5, 8, 13, 21, 22, 23, 25, 29, 35번 위치 아미노산 이외의 아미노산, 또한 20, 24, 31 및 32번 위치 아미노산 이외의 아미노산 1개 내지 7개이며,

가장 바람직하게는 10, 15, 16, 17, 18, 및 28번 위치의 아미노산 중 어느 하나이다.

(A-3)에서 서열번호 9의 서열과 최소한 42%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하다는 것은

바람직하게는 서열번호 9의 서열과 최소한 71%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산 및 5, 8, 13, 21, 22, 23, 25, 29, 35번 위치의 아미노산은 동일하고,

보다 바람직하게는 서열번호 9의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산, 5, 8, 13, 21, 22, 23, 25, 29, 35번 위치의 아미노산, 및 20, 24, 31, 및 32번 위치의 아미노산은 동일하며,

가장 바람직한 방법은 서열번호 9의 서열과 최소한 82%의 서열 동일성을 가지며, 다만 동일하지 않은 아미노산은 10, 15, 16, 17, 18, 및 28번 위치의 아미노산 중 어느 하나이다.

본 발명에 의해 제공되는 신규한 PPR 모티프로서, 시토신 결합성(cytosine-binding property)인 것은 이하의 (C-1), (C-2) 및 (C-3)이다:

(C-1) 서열번호 10의 서열로 구성되는 PPR 모티프, 또는 서열번호 10의 서열에 있어서 2번 위치 아미노산의 세린으로의 치환, 5번 위치 아미노산의 이소류신으로의 치환, 7번 위치 아미노산의 류신으로의 치환, 8번 위치 아미노산의 리신으로의 치환, 10번 위치 아미노산의 페닐알라닌 또는 티로신으로의 치환, 15번 위치 아미노산의 아르기닌으로의 치환, 22번 위치 아미노산의 발린으로의 치환, 24번 위치 아미노산의 아르기닌으로의 치환, 27번 위치 아미노산의 류신으로의 치환, 및 29번 위치 아미노산의 아르기닌으로의 치환으로 이루어진 군에서 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프;

(C-3) 서열번호 10의 서열과 최소한 25%의 서열 동일성을 가지되, 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 시토신 결합성인 PPR 모티프.

(C-1)에서의 치환은 1개라도 좋고, 2개 이상이라도 좋으며, 또한 상기 모두이어도 무방하다.

(C-2)에서 서열번호 10의 서열에 있어서 치환 등이 될 수 있는 아미노산인 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 25개는

바람직하게는 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산으로서 6, 9, 11, 12, 17, 20, 21, 23, 25, 28, 및 35번 위치 아미노산 이외의 아미노산 1개 내지 14개이고,

보다 바람직하게는 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산이고, 또한 6, 9, 11, 12, 17, 20, 21, 23, 25, 28, 및 35번 위치 아미노산 이외의 아미노산이며, 또한 13, 16, 31, 및 32번 위치 아미노산 이외의 아미노산 1개 내지 10개이고,

가장 바람직하게는 2, 5, 7, 8, 10, 15, 22, 24, 27, 및 29번 위치의 아미노산 중 어느 하나이다.

(C-3)에서 서열번호 10의 서열과 최소한 25%의 서열 동일성을 가지되, 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하다는 것은

바람직하게는 서열번호 10의 서열과 최소한 60%의 서열 동일성을 가지되, 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산 및 6, 9, 11, 12, 17, 20, 21, 23, 25, 28, 및 35번 위치의 아미노산은 동일하고,

보다 바람직하게는 서열번호 10의 서열과 최소 71%의 서열 동일성을 가지되, 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산, 6, 9, 11, 12, 17, 20, 21, 23, 25, 25, 28, 및 35번 위치의 아미노산, 및 13, 16, 31 및 32번 위치의 아미노산은 동일하며,

가장 바람직하게는 서열번호 10의 서열과 적어도 71%의 서열 동일성을 가지되, 동일하지 않은 아미노산은 2, 5, 7, 8, 10, 15, 22, 24, 27, 및 29번 위치의 아미노산 중 어느 하나이다.

본 발명에 의해 제공되는 신규한 PPR 모티프로서, 구아닌 결합성(guanine-binding property)인 것은 이하의 (G-1), (G-2) 및 (G-3)이다:

(G-1) 서열번호 11의 서열로 구성되는 PPR 모티프, 또는 서열번호 11의 서열에 있어서 10번 위치 아미노산의 페닐알라닌으로의 치환, 15번 위치 아미노산의 아스파라긴산으로의 치환, 27번 위치 아미노산의 발린으로의 치환, 28번 위치 아미노산의 세린으로의 치환, 및 35번 위치 아미노산의 이소류신으로의 치환으로 이루어진 군으로부터 선택된 어느 하나로 치환된 아미노산으로 이루어진 PPR 모티프;

(G-3) 서열번호 11의 서열과 최소한 40%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 구아닌 결합성인 PPR 모티프.

(G-1)에서의 치환은 1개라도 좋고, 2개 이상이라도 좋으며, 또한 상기 모두이어도 무방하다.

(G-2)에서 서열번호 11의 서열에서 치환 등이 될 수 있는 아미노산인 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 2개는

바람직하게는 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산이고, 또한 5, 11, 12, 17, 20, 21, 22, 23, 및 25번 위치 아미노산 이외의 아미노산 1개 내지 12개이며,

보다 바람직하게는 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산이고, 또한 5, 11, 12, 17, 20, 21, 22, 23, 및 25번 위치 아미노산 이외의 아미노산이며, 또한 8, 13, 16, 24, 29, 31, 및 32번 위치 아미노산 이외의 아미노산인 1개 내지 5개이고,

가장 바람직하게는 10, 15, 27, 28 및 35개의 아미노산 중 어느 하나이다.

(G-3)에서 서열번호 11의 서열과 최소한 40%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하다는 것은

바람직하게는 서열번호 11의 서열과 최소한 65%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산 및 5, 11, 12, 17, 20, 21, 22, 23, 및 25번 위치의 아미노산은 동일하고,

보다 바람직하게는 서열번호 11개의 서열과 최소 85%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산, 5, 11, 12, 17, 20, 21, 22, 23, 및 25번 위치의 아미노산, 및 8, 13, 16, 24, 29, 31, 및 32의 아미노산은 동일하며,

가장 바람직하게는 서열번호 11의 서열과 최소 85%의 서열 동일성을 가지되, 동일하지 않은 아미노산은 10, 15, 27, 28, 및 35번 위치의 아미노산 중 어느 하나이다.

본 발명에 의해 제공되는 신규한 PPR 모티프로서, 우라실 결합성(uracil-binding property)인 것은 이하의 (U-1), (U-2) 및 (U-3)이다:

(U-1) 서열번호 12의 서열로 구성되는 PPR 모티프, 또는 서열번호 12의 서열에 있어서 10번 위치 아미노산의 페닐알라닌으로의 치환, 13번 위치 아미노산의 세린으로의 치환, 15번 위치 아미노산의 리신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 20번 위치 아미노산의 류신으로의 치환, 21번 위치 아미노산의 리신으로의 치환, 23번 위치 아미노산의 페닐알라닌으로의 치환, 24번 위치 아미노산의 아스파라긴산으로의 치환, 27번 위치 아미노산의 리신으로의 치환, 28번 위치 아미노산의 리신으로의 치환, 29번 위치 아미노산의 아르기닌으로의 치환, 및 31번 위치 아미노산의 류신으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 배열로 이루어진 PPR 모티프;

(U-3) 서열번호 12의 서열과 최소 37%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 우라실 결합성인 PPR 모티프.

(U-1)에서의 치환은 1개라도 좋고, 2개 이상이라도 좋으며, 또한 상기 모두이어도 무방하다.

(U-2)에서 서열번호 12의 서열에 있어서 치환 등이 될 수 있는 아미노산인 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 22개는

바람직하게는 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산이고, 또한 5, 7, 9, 16, 18, 22, 25, 및 35번 위치 아미노산 이외의 1개 내지 14개이며,

보다 바람직하게는 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산이고, 또한 5, 7, 9, 16, 18, 22, 25, 및 35번 위치 아미노산 이외의 아미노산이며, 또한 8, 및 32번 위치 아미노산 이외의 아미노산 1개 내지 12개이며,

가장 바람직하게는 10, 13, 15, 17, 20, 21, 23, 24, 27, 28, 29, 및 31번 위치의 아미노산 중 어느 하나이다.

(U-3)에서 서열번호 12의 서열과 최소 37%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하다는 것은

바람직하게는 서열번호 12의 서열과 최소한 60%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산 및 5, 7, 9, 16, 18, 22, 25 및 35개의 아미노산은 동일하고,

보다 바람직하게는 서열번호 12의 서열과 최소한 65%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산, 위치 5, 7, 9, 16, 18, 22, 25, 및 35개의 아미노산 및 32개의 아미노산은 동일하며,

가장 바람직하게는 서열번호 12의 서열과 최소한 65%의 서열 동일성을 가지되, 동일하지 않은 아미노산은 10, 13, 15, 17, 20, 21, 23, 24, 27, 28, 29, 및 31번 위치의 아미노산 중 어느 하나이다.

한편, 본 발명자들에 의해 창출된 PPR 모티프 v2_A(서열번호 9), v2_C(서열번호 10), v2_G(서열번호 11), v2_U(서열번호 12)는 본 출원에서 처음으로 개시하는 것이며, 천연적으로는 존재하지 않는다. 또한, 그들 각각의 동족체(homologue, 상기 (A-1), (A-2), (A-3), (C-1), (C-2), (C-3), (G-1), (G-2), (G-3), (U-1), (U-2), (U-3)으로 나타낸 것과 그들의 바람직한 경우로 나타낸 것 중, 서열번호 9 내지 12 이외의 서열로부터 유래된 것)에 관하여는 (동족체 각각이 본 출원에서 처음으로 개시한 것인지 아닌지의 여부와 관계 없이 또는 천연에 존재하는지 아닌지의 여부와 관계없이), 동족체의 어느 하나를 2개 이상, 예를 들면, 3개, 4개, 5개, 6개, 7개, 8개, 9개, 10개, 11개, 12개, 13개, 14개를 조합한 것은 천연적으로 존재하지 않는다고 판단된다. 아울러, 본 발명에서 '어느 하나'라 할때, 선택되는 수는 임의의 수이다.

(신규한 PPR 모티프 서열에 대한 설명)

도 1 내지 도 4에는 아기장대(Arabidopsis thaliana)의 PPR 모티프 서열 중 1, 4, 및 (ii)번 위치의 아미노산 조합이 아데닌(A)을 인식하는 PPR 모티프는 VTN, 시토신(C)을 인식하는 PPR 모티프는 VSN, 구아닌(G)을 인식하는 PPR 모티프는 VTD, 우라실(U)을 인식하는 PPR 모티프는 VND인 PPR 모티프를 모아서, 각 위치에 출현하는 아미노산의 종류 및 그 개수를 집계하여 나타낸 것이다. 신규한 PPR 모티프 서열 v2_A(서열번호 9), v2_C(서열번호 10), v2_G(서열번호 11), v2_U(서열번호 12)에 있어서 모든 위치의 아미노산은 출현빈도가 높은 것을 나타낸다. 도 6의 A에는 이러한 신규한 서열과 함께, dPPR 모티프의 서열에 있어서, 1, 4, 및 (ii)번 위치의 아미노산 조합을 v2와 동일하게 한 v1_A(서열번호 13), v1_C(서열번호 14), v1_G(서열번호 15), v1_U(서열번호 16)을 나타내었다.

또한, 도 6의 A에는 v3.1 모티프의 아미노산 서열을 나타내었다. v3.1은 v2에서 아데닌 인식 모티프로 D15K 변이를 도입한 것이며(서열번호 401), 다른 사항은 v2와 동일하다. PPR 단백질에서 v3.1을 이용함으로써 v2보다 결합력이 향상된 것을 얻을 수도 있다.

아울러, 이하의 표 1 내지 표 4에는 서열번호 9 내지 12의 각 서열에서 아미노산의 출현빈도가 랜덤한 경우(예를 들어, 100개의 PPR 모티프를 수집하여, 어떤 위치에서 아미노산의 출현빈도(occurrence frequency)가 랜덤하다면, 20종의 아미노산이 5회씩 출현하게 된다)로부터 얼마나 차이가 나는지를 정리하였다. 어느 위치에서, 아미노산의 출현빈도가 랜덤한 경우로부터 벗어나서(deviated), 출현빈도가 높은(high) 경우에는, 진화적으로 수렴하고 있는 것으로(evolutionally converged), 그 위치의 아미노산은 기능과의 관련성이 높다고 추정할 수 있다. 기능과의 관련성이 높은 아미노산이라면 마찬가지로 랜덤한 경우로부터 벗어나고, 출현빈도가 높은 다른 아미노산으로 치환하여도 PPR 모티프로서의 기능은 유지될 수 있을 것이다.

(신규한 PPR 단백질)

본 발명은 신규한 PPR 모티프를 포함하는 신규한 PPR 단백질을 제공한다.

본 발명에 의해 제공되는 신규한 PPR 단백질은 다음과 같다:

n개의 염기서열로 이루어진 표적 RNA에 결합 가능한 n개의 PPR 모티프를 포함하는 단백질로서,

해당 염기서열 중의 아데닌에 대한 PPR 모티프가 위의 (A-1), (A-2), 또는 (A-3)의 PPR 모티프이고;

해당 염기서열 중의 시토신에 대한 PPR 모티프가 위의 (C-1), (C-2), 또는 (C-3)의 PPR 모티프이며;

해당 염기서열 중의 구아닌에 대한 PPR 모티프가 위의 (G-1), (G-2), 또는 (G-3)의 PPR 모티프이고;

해당 염기서열 중의 우라실에 대한 PPR 모티프가 위의 (U-1), (U-2), 또는 (U-3)의 PPR 모티프인 PPR 단백질.

PPR 단백질에 포함된 PPR 모티프의 바람직한 예는 PPR 모티프에 관한 상기 (A-1), (A-2), (A-3), (C-1), (C-2), (G-1), (G-2), (G-3), (U-1), (U-2), 또는 (U-3)에 대한 설명이 그대로 적용된다.

본 발명에서의 PPR 단백질에서 n(1 이상의 정수를 나타냄)은 특별히 한정되는 것은 아니나 10 이상일 수 있으며, 12 이상이 바람직하고, 15 이상이 보다 바람직하며, 18 이상이 더욱 바람직하다. 모티프 수를 늘림으로써, 많은 표적에 대해 높은 결합강도를 갖는 PPR 단백질을 작제할 수 있다.

이하의 표에 나타낸 것처럼, 지금까지 7개 내지 14개의 모티프로 이루어진 인공 PPR 단백질의 작제가 보고된 한편, 많은 PPR 모티프가 포함되어 이를 암호화하는 유전자 서열에서 염기서열상의 반복이 많을 수밖에 없는 유전자를 구축하는 것은 어려운 것으로 여겨져 왔다. 또한, 일반적으로 반복서열(repeat sequence)을 포함하는 유전자를 만들 때, 클로닝 과정에서 반복되는 부분이 재결합하는 등 작제가 어려운 경우가 있다(참조: Trinh, T. et al. An Escherichia coli Strain for the Stable Propagation of Retroviral Clones and Direct Repeat Sequences. Focus, 16, 78-80(1994)).

15개 이상의 PPR 모티프를 가지는 PPR 단백질의 유전자를 구축할 때에는 코돈의 축퇴(codon degeneracy)를 이용하고, 각 모티프에서 결합에 관여하는 1번, 4번, (ii)번을 제외한 아미노산(후술하는 Golden Gate법을 이용하는 경우에는, 공통으로 하는 양단 부근을 제외한 5번째 내지 33번째의 29개 아미노산)을 암호화하는 염기서열을 각 모티프간에 적절히 다르게 한다. 개변의 정도는 당업자가 설계할 수 있는데, 예를 들어 4.5% 이상(87개 염기에서, 4개소 이상), 15% 이상 또는 30% 이상(87개 염기에서, 26개 이상)의 염기를 다르게 만들 수 있다.

기존의 v1 내지 v4 모티프(서열번호 13 내지 16)를 암호화하는 염기서열로부터의 코돈 축퇴를 이용한 모티프를 암호화하는 염기서열의 예로 아래 표와 같은 서열을 들 수 있다.

또한, 본 명세서에 사용되는 '작제'라는 용어는 '생산' 또는 '제조'로 바꿔 말할 수 있다. 또한, 유전자 등과 관련하여 파트를 조합하여 작제하는 경우 '구축'이라고 할 수 있으나, '구축'도 '생산' 또는 '제조'라고 바꿔 말할 수 있다.

(PPR 모티프, PPR 단백질을 암호화하는 핵산)

본 발명은 신규한 PPR 모티프 및 이를 포함하는 신규한 PPR 단백질을 암호화하는 핵산을 제공한다. 새로운 PPR 모티프를 암호화하는 염기서열은 코돈의 축퇴에 따라 여러가지 종류가 있다.

본 발명에서의 신규한 PPR 모티프의 아미노산 서열 v2_A(서열번호 9), v2 _C(서열번호 10), v2_G(서열번호 11), v2_U(서열번호 12)를 암호화하는 염기서열의 바람직한 예를 이하의 표 7에 나타냈다.

명 칭	염 기 서 열	서열번호
v2_A1_1	GTCACATACACCACACTGATCGACGGACTGTGTAAAGCCGGCGACGTGGACGAAGCCCTCGAGCTGTTCAAAGAGATGCGGAGCAAGGGCGTGAAGCCCAACGTG	358
v2_C1_1	GTCACATACAACACCCTGATCGACGGCCTGTGCAAGGCCGGCAGACTGGATGAGGCCGAGGAGCTGCTGGAGGAGATGGAGGAGAAGGGCATCAAGCCCGACGTG	359
v2_G1_1	GTCACATACACCACCCTGATCGACGGCCTGTGCAAGGCCGGCAAGGTGGATGAGGCCCTGGAGCTGTTCGACGAGATGAAGGAGAGGGGCATCAAGCCCGACGTG	360
v2_U1_1	GTCACATACAACACCCTGATCGACGGCCTGTGCAAGAGCGGCAAGATCGAGGAGGCCCTGAAGCTGTTCAAGGAGATGGAGGAGAAGGGCATCACCCCCAGCGTG	361
v2_G2_1	GTCACATACACCACCCTGATCGACGGCCTGTGCAAGGCCGGCAAAGTGGACGAGGCCCTGGAGCTGTTCGACGAGATGAAGGAGAGGGGCATCAAGCCCGACGTG	362
v2_A1_2	GTGACATACACCACACTGATCGACGGACTGTGTAAAGCCGGCGACGTGGACGAAGCCCTCGAGCTGTTCAAAGAGATGCGGAGCAAGGGCGTGAAGCCCAACGTG	363
v2_C1_2	GTGACATACAACACCCTGATCGACGGCCTGTGCAAGGCCGGCAGACTGGATGAGGCCGAGGAGCTGCTGGAGGAGATGGAGGAGAAGGGCATCAAGCCCGACGTG	364
v2_G1_2	GTGACATACACCACCCTGATCGACGGCCTGTGCAAGGCCGGCAAGGTGGATGAGGCCCTGGAGCTGTTCGACGAGATGAAGGAGAGGGGCATCAAGCCCGACGTG	365
v2_U1_2	GTGACATACAACACCCTGATCGACGGCCTGTGCAAGAGCGGCAAGATCGAGGAGGCCCTGAAGCTGTTCAAGGAGATGGAGGAGAAGGGCATCACCCCCAGCGTG	366
v2_G2_2	GTGACATACACCACCCTGATCGACGGCCTGTGCAAGGCCGGCAAAGTGGACGAGGCCCTGGAGCTGTTCGACGAGATGAAGGAGAGGGGCATCAAGCCCGACGTG	367
v2_A1_3	GTTACATACACCACACTGATCGACGGACTGTGTAAAGCCGGCGACGTGGACGAAGCCCTCGAGCTGTTCAAAGAGATGCGGAGCAAGGGCGTGAAGCCCAACGTG	368
v2_C1_3	GTTACATACAACACCCTGATCGACGGCCTGTGCAAGGCCGGCAGACTGGATGAGGCCGAGGAGCTGCTGGAGGAGATGGAGGAGAAGGGCATCAAGCCCGACGTG	369
v2_G1_3	GTTACATACACCACCCTGATCGACGGCCTGTGCAAGGCCGGCAAGGTGGATGAGGCCCTGGAGCTGTTCGACGAGATGAAGGAGAGGGGCATCAAGCCCGACGTG	370
v2_U1_3	GTTACATACAACACCCTGATCGACGGCCTGTGCAAGAGCGGCAAGATCGAGGAGGCCCTGAAGCTGTTCAAGGAGATGGAGGAGAAGGGCATCACCCCCAGCGTG	371
v2_G2_3	GTTACATACACCACCCTGATCGACGGCCTGTGCAAGGCCGGCAAAGTGGACGAGGCCCTGGAGCTGTTCGACGAGATGAAGGAGAGGGGCATCAAGCCCGACGTG	372

dPPR 모티프에 있어서 1, 4, 및 (ii)번 위치의 아미노산 조합을 v2와 동일하게 한 PPR 모티프의 아미노산 서열, v1_A(서열번호 13), v1_C(서열번호 14), v1_G(서열번호 15), v1_U(서열번호 16)을 암호화하는 염기서열을 이하의 표 8에 나타내었다.

명 칭	서 열 번 호	서열번호
v1_A1_1	GTCACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGCAAATTAGATGAGGCCCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGCATCAAGCCGAACGTG	373
v1_C1_1	GTCACATACAACACCCTGATTGATGGCTTATGCAAAGCGGGTAAGCTGGATGAAGCGTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGTATTAAACCGAGCGTG	374
v1_G1_1	GTCACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGTAAATTAGATGAAGCGCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGTATCAAGCCGGATGTG	375
v1_U1_1	GTCACATACAATACGCTGATTGATGGCTTATGTAAAGCGGGTAAGCTGGATGAGGCCTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGCATTAAACCGGATGTG	376
v1_G2_1	GTCACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGTAAATTAGATGAAGCGCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGTATCAAGCCGGACGTG	377
v1_U2_1	GTCACATACAATACGCTGATTGATGGCTTATGTAAAGCGGGTAAGCTGGATGAGGCCTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGCATTAAACCGGACGTG	378
v1_A1_2	GTGACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGCAAATTAGATGAGGCCCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGCATCAAGCCGAACGTG	379
v1_C1_2	GTGACATACAACACCCTGATTGATGGCTTATGCAAAGCGGGTAAGCTGGATGAAGCGTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGTATTAAACCGAGCGTG	380
v1_G1_2	GTGACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGTAAATTAGATGAAGCGCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGTATCAAGCCGGATGTG	381
v1_U1_2	GTGACATACAATACGCTGATTGATGGCTTATGTAAAGCGGGTAAGCTGGATGAGGCCTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGCATTAAACCGGATGTG	382
v1_G2_2	GTGACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGTAAATTAGATGAAGCGCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGTATCAAGCCGGACGTG	383
v1_U2_2	GTGACATACAATACGCTGATTGATGGCTTATGTAAAGCGGGTAAGCTGGATGAGGCCTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGCATTAAACCGGACGTG	384
v1_A1_3	GTTACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGCAAATTAGATGAGGCCCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGCATCAAGCCGAACGTG	385
v1_C1_3	GTTACATACAACACCCTGATTGATGGCTTATGCAAAGCGGGTAAGCTGGATGAAGCGTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGTATTAAACCGAGCGTG	386
v1_G1_3	GTTACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGTAAATTAGATGAAGCGCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGTATCAAGCCGGATGTG	387
v1_U1_3	GTTACATACAATACGCTGATTGATGGCTTATGTAAAGCGGGTAAGCTGGATGAGGCCTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGCATTAAACCGGATGTG	388
v1_G2_3	GTTACATACACCACGCTGATCGATGGTCTGTGTAAGGCCGGTAAATTAGATGAAGCGCTGAAGTTATTCGAAGAGATGGTTGAAAAAGGTATCAAGCCGGACGTG	389
v1_U2_3	GTTACATACAATACGCTGATTGATGGCTTATGTAAAGCGGGTAAGCTGGATGAGGCCTTAAAACTGTTTGAGGAAATGGTGGAGAAGGGCATTAAACCGGACGTG	390

PPR 단백질을 암호화하는 염기서열은 위의 서열 중 어느 하나의 조합으로 구성될 수 있다. 아미노산 서열 v2_A(서열번호 9), v2_C(서열번호 10), v2_G(서열번호 11), v2_U(서열번호 12)를 암호화하는 염기서열과 v1_A(서열번호 16)를 암호화하는 염기서열과 v1_A(서열번호 13), v1_C(서열번호 14), v1_G(서열번호 15), v1_U(서열번호 16)를 암호화하는 염기서열을 적절히 조합하여 단백질을 암호화하는 아미노산을 구성해도 된다..

본 발명에서의 신규한 PPR 모티프의 아미노산 서열 v3.1_A(서열번호 401), 1st_A(서열번호 402), 1st_C(서열번호 403), 1st_G(서열번호 404), 1st_U(서열번호 405)를 암호화하는 염기서열의 바람직한 예를 하기 표 9에 나타내었다.

명 칭	염 기 서 열	서열번호
v3.1_A	GTGACCTACACCACACTGATCGACGGACTGTGCAAGGCCGGCAAAGTGGATGAGGCTCTGGAGCTGTTTAAGGAAATGAGAAGCAAGGGCGTCAAGCCCAACGTG	406
v3.2_A (1st_A)	GTCACATACACCACCAACATCGACCAGCTGTGCAAAGCCGGCAAGGTGGATGAAGCTCTGGAGCTGTTCAAGGAGATGAGAAGCAAGGGCGTGAAGCCCAACGTG	407
v3.2_C (1st_C)	GTCACATACAACACCAACATCGACCAGCTGTGCAAAAGCGGCAAGATCGAGGAGGCTCTGAAACTGTTCAAGGAGATGGAGGAGAAGGGCATCACCCCCAGCGTG	408
v3.2_G (1st_G)	GTCACATACACCACCAACATCGACCAGCTCTGCAAGGCCGGCAAGGTGGATGAGGCTCTGGAGCTGTTCGACGAGATGAAGGAGAGAGGCATCAAGCCCGACGTG	409
v3.2_U (1st_U)	GTCACATACAACACCAACATCGACCAGCTCTGCAAGGCCGGCAGACTGGACGAGGCCGAAGAGCTGCTGGAGGAGATGGAGGAGAAGGGCATCAAGCCCGACGTG	410

PPR 단백질을 암호화하는 염기서열은 위의 서열 중 어느 하나의 조합으로 구성될 수 있다. N-말단 측에서 1번째 PPR 모티프를 암호화하는 염기서열로는 상기 v3.2_X로부터 선택되는 어느 하나를 이용하고, 이후 PPR 모티프를 암호화하는 염기서열로는 아데닌에 대한 PPR 모티프를 암호화하는 염기서열로서 상기 v3.1_A를 선택하고, 시토신, 구아닌 및 우라실에 대한 PPR 모티프를 암호화하는 염기서열로서는 상기 v2 시리즈로부터 선택한 것을 적의 조합하는 것이 바람직하다.

(응집성의 개선)

본 발명자들은 천연으로 존재하는 기존 PPR 모티프의 아미노산 정보에서 PPR 모티프의 6번째 위치의 아미노산은 소수성(특히 류신), 9번째 위치의 아미노산은 비친수성 아미노산(특히 글리신)인 경우가 매우 많음을 찾아냈다. 이미 결정 구조가 알려진 PPR 단백질의 구조(참조: 비특허문헌 6: Coquille et al., 2014 Nat. Commun.; PDB ID: 4PJQ, 4WN4, 4WSL, 4PJR; 비특허문헌 7: Shen et al., 2015 Nat. Commun., PDB ID: 5I9D, 5I9F, 5I9G, 5I9H)로부터, 1번째 모티프(N-말단)의 6번째 및 9번째 아미노산은 외부에 노출되기 때문에, 그 노출된 소수성 아미노산이 응집성을 야기시키는 것으로 추정하였다(도 6A). 한편, 2번째 모티프 및 그 이후의 모티프에서의 6번째, 9번째 아미노산은 단백질 내에 파묻혀 소수성 코어(hydrophobic core)를 형성하기 때문에, 모든 모티프의 6번째, 9번째 아미노산에 친수성 잔기가 배치되면 단백질 구조가 붕괴되는 것으로 판단되었다. 이에, 1번째 모티프에서만 6번째 아미노산, 바람직하게는 6번째 및 9번째 아미노산을 친수성 아미노산(아스파라긴, 아스파라긴산, 글루타민, 글루탐산, 리신, 아르기닌, 세린, 트레오닌)으로 치환함으로써, PPR의 응집성을 감소시키기고자 하였다.

구체적으로는 다음과 같이 한다.

특정 염기서열을 가지는 표적 핵산과 결합 가능한 단백질의 N-말단 측에서 1번째 PPR 모티프(M1)에서:

(1) A₆ 아미노산을 친수성 아미노산, 바람직하게는 A₆ 아미노산을 아스파라긴 또는 아스파라긴산으로 한다.

(2) 또한, A₉아미노산을 친수성 아미노산 또는 글리신, 바람직하게는 글루타민, 글루탐산, 리신 또는 글리신으로 한다.

(3) 혹은, A₆ 아미노산 및 A₉아미노산을 다음 중 어느 하나의 조합으로 한다.

·A₆아미노산이 아스파라긴이고, A₉아미노산이 글루탐산인 조합

·A₆ 아미노산이 아스파라긴이고, A₉아미노산이 글루타민인 조합

·A₆아미노산이 아스파라긴이고, A₉아미노산이 리신인 조합

·A₆아미노산이 아스파라긴산이고, A₉아미노산이 글리신인 조합

이와 같은 PPR 모티프 중 특히 선호되는 것은 다음과 같다:

(1st_A-1) 서열번호 402의 서열에 있어서 6번 및 9번 위치의 아미노산이 이하에 정의된 조합 중 어느 하나를 만족하도록 치환된 PPR 모티프;

(1st_C-1) 서열번호 403의 서열로 구성되는 PPR 모티프;

(1st_G-3) (1st_G-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34의 아미노산은 동일하고 구아닌 결합성인 PPR 모티프;

(1st_U-1) 서열번호 405의 서열에 있어서 6번 및 9번 위치의 아미노산이 이하에 정의된 조합 중 어느 하나를 만족하도록 치환된 서열로 구성되는 PPR 모티프;

(1st_U-2) (1st_U-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 우라실 결합성인 PPR 모티프;

(1st_U-3) (1st_U-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 우라실 결합성인 PPR 모티프.

·6번 위치의 아미노산 아스파라긴산이고, 9번 위치의 아미노산이 글리신인 조합

도 6의 A에 v3.1 모티프와 함께 v3.2 모티프의 아미노산 서열을 나타내었다. v3.2는 1번째 모티프는 1st_A(서열번호 402), 1st_C(서열번호 403), 1st_G(서열번호 404), 1st_U(서열번호 405)를 선택하고, 2번째 이후의 모티프는 v2_C, v2_G, v2_U, v3.1_A 중에서 선택한다. PPR 단백질에서 N-말단에서 1번째 PPR 모티프로서 v3.2 중 어느 하나를 사용함으로써 세포 내 응집을 개선할 수 있다.

(기타)

본 발명에서 염기서열('뉴클레오티드서열'이라고도 함) 또는 아미노산 서열에 관하여 '동일성(identity)'이라 함은, 특별히 기재한 경우를 제외하고는 두 서열을 최적의 양태로 정렬시켰을때, 두 서열간에 공유하는 일치된 염기 또는 아미노산 개수의 백분율을 의미한다. 즉, 동일성=(일치한 위치의 수/위치의 전수)×100으로 산출할 수 있고, 시판되는 알고리즘을 이용하여 계산할 수 있다. 또한, 이러한 알고리즘은 [Altschul et al., J. Mol. Biol. 215(1990) 403-410]에 기재된 NBLAST 및 XBLAST 프로그램에 포함되어 있다. 구체적으로, 염기서열 또는 아미노산 서열의 동일성에 관한 검색 및 분석은 당업계에 알려진 알고리즘 또는 프로그램(예를 들어, BLASTN, BLASTP, BLASTX, Clustal W)으로 수행할 수 있다. 프로그램을 이용할 경우의 파라미터는 당업자라면 적절하게 설정할 수 있고, 각 프로그램의 디폴트 파라미터(default parameter)를 이용해도 된다. 이들 분석방법의 구체적인 기법도 당업자에 널리 알려져 있다.

본 명세서에서 염기서열 또는 아미노산 서열에 관해 동일성이 있다(또는 동일성이 높다)함은, 특별히 기재한 경우를 제외하고는 어느 경우나 최소한 70%, 바람직하게는 80% 이상, 보다 바람직하게는 85% 이상, 보다 더 바람직하게는 90% 이상, 보다 더 바람직하게는 95% 이상, 보다 더 바람직하게는 97.5% 이상, 가장 바람직하게는 99% 이상의 동일성을 가지는 경우를 일컫는다.

또한, 본 발명에서의 PPR 모티프 또는 단백질에 관하여, '치환, 결실 또는 부가된 서열'이라고 할 경우, 치환 등이 되는 아미노산의 개수는 특히 기재하였을 경우를 제외하고, 어느 모티프 또는 단백질에서도 그 아미노산 서열로 구성된 모티프 또는 단백질이 원하는 기능을 가지는 한 특별히 한정되는 것은 아니나, 1개 내지 9개 또는 1개 내지 4개 정도이다. 이러한 아미노산 서열과 관련된 폴리뉴클레오티드 또는 단백질을 제조하기 위한 수단은 당업자에게 잘 알려져 있다.

　 성질이 비슷한 아미노산이라 함은 하이드로파시(hydropathy), 하전(charge), pKa, 용해도(solubility) 등 물성이 유사한 아미노산을 의미하며, 예를 들어 다음과 같은 것을 가리킨다.

소수성(hydrophobic) 아미노산: 알라닌, 발린, 글리신, 이소류신, 류신, 페닐알라닌, 프롤린, 트립토판, 티로신;

비소수성(non-hydrophobic) 아미노산: 아르기닌, 아스파라긴, 아스파라긴산, 글루타민산, 리신, 세린, 트레오닌, 시스테인, 히스티딘;

친수성(hydrophilic) 아미노산: 아르기닌, 아스파라긴, 아스파라긴산, 글루타민산, 리신, 세린, 트레오닌;

산성(acidic) 아미노산: 아스파라긴산, 글루탐산

염기성(basic) 아미노산: 리신, 아르기닌, 히스티딘

중성(neutral) 아미노산: 알라닌, 아스파라긴, 시스테인, 글루타민, 글리신,이소류신, 류신, 메티오닌, 페닐알라닌, 프롤린, 세린, 트립토판, 티로신, 발린

함황(sulfur-containing) 아미노산: 메티오닌, 시스테인

함방향환(aromatic ring-containing) 아미노산: 티로신, 트립토판, 페닐알라닌.

본 발명의 PPR 모티프, 그를 포함하는 단백질 또는 이를 암호화하는 핵산은 당업자라면 공지기술을 이용하여 제조할 수 있다.

[신규한 PPR 모티프 성능]

(결합력)

본 발명에서의 신규한 PPR 모티프(서열번호 9 내지 12)를 이용하여 작제한 PPR 단백질은 비교적 긴 표적 RNA에 대한 PPR 단백질 작제에 적합할 뿐만 아니라, 동일한 표적 RNA에 대한 기존의 PPR(서열번호 13 내지 16) 모티프를 이용하여 작제한 PPR 단백질보다 높은 RNA 결합능력을 보유한다.

즉, PPR 단백질에서 본 발명에서의 신규한 PPR 모티프를 이용함으로써 기존의 PPR 모티프를 사용한 경우보다도 표적 RNA에 대한 결합력을 높일 수 있다. 결합력이 높아짐으로써 PPR 단백질에 의한 세포 내 RNA 조작 효율(manipulation efficiency)이 향상될 수 있다. 예를 들어, 세포 내에서의 접합 효율(efficiency of intracellular splicing)이 표적에 대한 결합력이 높은 PPR 단백질을 이용하면 향상될 수 있다(실시예 5 참조).

결합력을 높일 수 있는 정도는 표적의 서열이나 길이에 따라 결정되는 것으로 추정되고, 결합력은 예를 들어 1.1배 이상, 구체적으로 1.3배 이상, 2.0배 이상, 3.0배 이상, 3.6배 이상 증대될 수 있다.

표적서열에 대한 결합력은 EMSA(Electrophoretic Mobility Shift Assay)나 Biacore를 이용한 방법에 따라 평가할 수 있다. EMSA는 단백질과 핵산이 결합된 시료를 전기영동시 핵산분자의 이동도가 결합되지 않은 경우와 비교하여 변화하는 성질을 이용하는 방법이다. Biacore로 대표되는 분자간 상호작용 분석기기는 반응속도론적 분석이 가능하므로, 상세한 단백질-핵산결합 분석이 가능하다.

또한, 표적서열에 대한 결합력은 후술하는 RPB-ELISA에 의해서도 평가할 수 있다. RPB-ELISA에서는 대상 PPR 단백질과 그 표적 RNA를 더한 시료의 발광량으로부터 백그라운드 신호 값(표적 RNA를 가하지 않고 대상 PPR 단백질을 가하였을 때의 발광 신호 값)을 공제한 값을 대상 PPR와 그 표적 RNA와의 결합력으로 측정할 수 있다.

(특이성)

본 발명의 신규한 PPR 모티프를 이용하여 작제한 PPR 단백질은 표적서열에 대한 특이성에 있어서 동일한 표적 RNA에 대한 기존의 PPR 모티프를 이용하여 작제한 PPR 단백질보다 높은 능력을 가질 수 있다.

즉, PPR 단백질에서 본 발명에서의 신규한 PPR 모티프를 이용함으로써 기존의 PPR 모티프를 이용하였을 경우보다 표적 RNA에 대한 특이성을 높일 수 있다. 표적 RNA에 대한 특이성이 높은 PPR 단백질이라면, 이를 이용하여 세포 내에서 표적 RNA를 조작할 경우, 의도하지 않은 RNA에 결합하여 의도하지 않은 효과가 나타나는 것을 피할 수 있다.

표적서열에 대한 친화성은 당업자라면 통상적인 방법으로 평가할 수 있다. 또한, RPB-ELISA에서는 대상 PPR 단백질에 대해 적절한 비표적 RNA를 설계하고 이 경우의 결합력(발광 신호 값)을 동일하게 구함으로써, 표적 서열(target sequence)에 대한 결합 신호 값/비표적 서열(non-target sequence)에 대한 결합 신호 값(S/N)을 표적 RNA에 대한 특이성(친화성) 지표로서 구할 수 있다.

(Kd 값)

본 발명에서의 신규한 PPR 모티프를 사용하여 작제한 PPR 단백질은 표적 RNA에 대해 높은 친화성(평형해리승수, Kd 값)을 가질 수 있다.

표적서열에 대한 Kd 값은 EMSA 등 기존의 통상적인 방법에 의해 산출할 수 있다. 본 발명에서 Kd 값을 말할 때는, 특히 기재하였을 경우를 제외하고, 후술하는 실시예에 기재된 조건으로 EMSA에 의해 측정하였을 때의 값을 의미한다.

본 발명의 신규한 PPR 모티프를 이용하여 작제한 PPR 단백질의 Kd 값은 표적의 서열이나 길이에 따를 것으로 추정되지만, 표적서열의 길이가 18개 염기 길이 이상일 경우에는 10^-7M 이하일 수 있으며, 10^-8M 이하, 혹은 10^-9M 오더(order)로 될 수 있다. 본 발명자들의 검토에 따르면, 표적서열의 길이가 18개 염기 길이일 경우 실시예의 조건에서 Kd 값의 최소치(높은 친화성)는 1.95 x 10^-9로 지금까지 알려진 설계된 PPR 단백질의 Kd 값(표 1 참조) 중 어느 것보다 낮다. 아울러, Kd 값은 RPB-ELISA에서의 결합실험으로 얻은 신호 값에 상관하는 것으로 알려졌다. RPB-ELISA 에서의 발광치(실시예에 기재된 조건에 의한다)가 1 ~ 2 x 10⁷의경우, Kd 값이 10^-6내지 10^-7 M, RPB-ELISA 에서의 발광치가 2 ~ 4 x 10⁷의경우, Kd 값이 10^-7 내지 10^-8 M, RPB-ELISA 에서의 발광치가 4 x 10⁷ 보다 큰경우, Kd 값이 10^-8 이하인 것으로 추정된다.

(PPR 단백질의 구축 효율)

본 발명의 신규한 PPR 모티프를 사용하면, 원하는 PPR 단백질을 효율적으로 구축할 수 있다. 구축 효율(construction efficiency)은 기존의 방법을 사용하여 높은 Kd 값을 갖는 PPR 단백질이 구축된 비율을 구함으로써 산출할 수 있다. Kd 값 대신에, 상술한 바와 같이 RPB-ELISA에 의한 발광 신호 값을 이용하여 산출할 수도 있다.

구체적으로, 본 발명의 신규한 PPR 모티프를 이용함으로써 표적서열의 길이가 18개 염기 길이일 경우, Kd 값이 10^-6 M 이하(RPB-ELISA 값이 1 x 10⁷ 이상)인 PPR 단백질이 50% 이상, 바람직하게는 60% 이상, 보다 바람직하게는 70% 이상, 보다 더 바람직하게는 80% 이상의 효율로 얻을 수 있다. 또한, 본 발명에 의하면 Kd 값이 10^-7M 이하(RPB-ELISA 값이 2 x 10⁷ 이상)인 표적서열이 18개 염기 길이인 PPR 단백질은 50% 이상, 바람직하게는 55% 이상, 보다 바람직하게는 65% 이상, 보다 더 바람직하게는 75% 이상의 효율로 얻을 수 있다. 또한, 본 발명에 의해 Kd 값이 10^-8M 이하(RPB-ELISA 값이 4 x 10⁷ 이상)인 표적서열이 18개 염기 길이인 PPR 단백질은 20% 이상, 바람직하게는 25% 이상, 보다 바람직하게는 30% 이상, 보다 더 바람직하게는 35% 이상의 효율로 얻을 수 있다.

구축 효율은 RPB-ELISA법을 이용하여 표적서열(target sequence)에 대한 결합신호 값/비표적서열(non-target sequence)에 대한 결합신호 값(S/N)을 바탕으로 산출할 수 있다.

구체적으로, 본 발명에서의 신규한 PPR 모티프를 사용함으로써 표적서열이 18개 염기 길이이며 S/N이 10보다 높은 PPR 단백질을 50% 이상, 바람직하게는 55% 이상, 보다 바람직하게는 65% 이상, 보다 더 바람직하게는 75% 이상의 효율로 얻을 수 있다. 또한, 본 발명에 따라 표적서열이 18개 염기 길이이며 S/N이 100보다 높은 PPR 단백질은 15% 이상, 바람직하게는 20% 이상, 보다 바람직하게는 25% 이상, 보다 더 바람직하게는 30% 이상의 효율로 얻을 수 있다.

[파트 라이브러리를 이용한 PPR 단백질 유전자의 심리스 클로닝(seamless cloning)]

또한, 본 발명은 다음과 같은 공정을 포함하는 n개의 염기서열로 이루어진 표적 핵산에 결합가능한 n개의 PPR 모티프를 포함하는 단백질을 암호화하는 유전자 작제방법을 제공한다:

아데닌, 시토신, 구아닌, 또는 우라실 혹은 티민에 결합하는 PPR 모티프 각각을 암호화하는 4종 및 PPR 모티프의 2개의 연결물 각각을 암호화하는 16종을 포함하는 최소한 20종의 폴리뉴클레오티드가 최소 m 종의 순으로 연결 가능하도록 설계된 중간 벡터 Dest-a... 의 각각에 삽입된, 최소한 20×m종의 PPR 파트의 라이브러리로부터, 목적으로 하는 유전자를 작제하기 위해 필요한 m개의 PPR 파트를 선택하고, 선택한 m 종의 PPR 파트를 벡터 파트과 함께 Golden Gate 반응에 제공됨으로써, m개의 폴리뉴클레오티드 연결물이 삽입된 벡터를 얻는다. n은 m 이상이고, m×2이하의 정수이다. 예를 들어, n은 10 내지 20일 수 있다.

본 발명의 방법은 Golden Gate 반응을 이용한다. Golden Gate 반응에서는 Type IIS 제한효소와 T4 DNA 연결효소를 사용하여, 여러 개의 DNA 단편을 벡터에 삽입한다. Type IIS 제한효소는 인식서열 바깥쪽을 절단하므로, 부착말단(cohesive end)을 자유롭게 설정할 수 있다. 또한, 4개 염기의 돌출말단(protruding end)을 연결에 이용하기 때문에 효율성이 높다. 아울러, 결합(annealing) 및 연결(ligation)하여 수득한 구성체(construct) 중에는 인식서열이 남지 않는다. 따라서, PPR 모티프를 암호화하는 폴리뉴클레오티드를 매끄럽게(seamlessly) 연결할 수 있다(도 5). Type IIS 제한효소의 특히 바람직한 예는 Bsa I이다.

본 발명의 방법은 PPR 단백질의 특징을 고려하여 적절하게 설계된 파트 라이브러리(part library)와 Golden Gate 반응으로, 반복서열(repeat sequence)이 많은 경우에도 효율적으로 유전자를 작제할 수 있다. 따라서, 이 방법은 반복서열이 많아지는 15개의 염기 길이 이상의 표적 핵산에 결합할 수 있는 15개 이상의 PPR 모티프가 함유된 단백질 유전자를 작제할때 유용하다. m을 10으로 하고 200종의 PPR 파트 라이브러리를 사용하여 라이브러리에서 원하는 유전자를 작제하기 위해 필요한 10개의 PPR 파트를 선택하면, 10개 내지 20개의 PPR 모티프를 포함하는 단백질을 암호화하는 유전자를 자유자재로 작제할 수 있다. 이하에서는 표적서열이 10개 내지 20개 염기 길이인 RNA 결합성 PPR 단백질을 암호화하는 유전자를 작제하는 경우를 예로 설명한다. 이 방법은 다른 길이의 표적서열에 대한 PPR 단백질을 제조하기 위해서도 응용할 수 있고, DNA 결합성 PPR 단백질을 제조하기 위해서도 응용할 수 있다.

본 발명의 방법에서는 PPR 모티프를 암호화하는 서열을 1개 또는 2개 포함하는 파트 라이브러리를 작제하여(도 5의 STEP1 및 STEP2) 사용한다. 파트 라이브러리는 예를 들어 10종의 중간 벡터(intermediate vector) Dest-a, b, c, d, e, f, g, h, i, j에 PPR 모티프 서열을 삽입함으로써 작제할 수 있다. 중간 벡터는 Golden Gate 반응에 의해 Dest-a 내지 Dest-j의 순서대로 매끄럽게(seamlessly) 연결되도록 설계된다. 삽입되는 PPR 모티프 서열은 각각을 암호화하는 4종(A, C, G, U) 및 PPR 모티프의 2개의 연결산물(ligation product) 각각을 암호화하는 16종(AA, AC, AG, AU, CA, CC, CG, CU, GA, GC, GG, GU, UA, UC, UG, UU)을 포함하여 적어도 20종으로 구성된다. 이 경우 파트 라이브러리는 적어도 200종의 파트를 포함한다.

이어, 표적 염기서열에 따라 필요한 파트를 선택한다. 구체적으로, 예를 들어 Dest-a,b,c,d,e,f,g,h,i,j 각각의 파트 라이브러리에서 각 1개의 파트를 선택하고, 벡터 파트와 함께 Golden Gate 반응을 실시한다(도 5의 STEP3). 모든 중간 벡터에 1개의 모티프가 들어간 것을 선택하면 10개의 서열이 연결되고, 2개의 모티프가 들어간 것을 사용하면 2개의 모티프가 들어간 것을 사용한다. 11개 내지 19개를 연결할 경우에는, 임의의 Dest-x 라이브러리에서 1개의 모티프가 들어간 것을 선택하면 된다.

STEP3에서 이용하는 벡터 파트는 3종(가장 C-말단 측에 배치되는 PPR 모티프의 (ii)번 아미노산을 고려할 필요가 있으나, 구아닌 결합성의 PPR 모티프와 우라실 결합성 PPR 모티프는 (ii)번 아미노산이 같다)의 CAP-x 벡터(참조: 비특허문헌 1) 중에서 선택할 수 있다. 가장 C-말단쪽에 위치한 모티프가 인식하는 염기서열이 아데닌일 경우 CAP-A, 시토신일 경우 CAP-C, 구아닌 또는 우라실일 경우 CAP-GU를 각각 사용한다.

얻어진 플라스미드는 대장균으로 형질전환하여 증폭·추출할 수 있다.

[PPR 단백질 검출 또는 분석방법]

본 발명은 고상화된 표적 핵산에 후보 단백질을 포함하는 용액을 제공하여 표적 핵산에 결합하는 단백질을 검출 또는 정량하는 공정을 포함하는 n개의 염기서열로 이루어진 표적 핵산에 결합가능한 n개의 PPR 모티프를 포함하는 단백질을 검출 또는 정량하는 방법을 제공한다:

본 발명의 검출, 분석방법은 고속 대량으로(high throughput) PPR 단백질의 결합능력을 평가하는 방법으로 유용하다.

본 발명의 검출·분석방법은 ELISA(Enzyme-Linked Immuno Sorbent Assay)를 응용한 것이므로(도 7의 A), RPB-ELISA(RNA-protein binding ELISA)법이라 칭하기도 한다. 또한, 본 발명의 방법은 본 명세서에서 RNA 결합성의 PPR 단백질을 평가하는 방법으로 설명하고 있으나, DNA 결합성의 PPR 단백질이 표적 DNA에 대한 결합능력을 평가하기 위해서도 응용할 수 있다.

고상화된 표적 핵산에 후보 단백질을 포함하는 용액을 제공하는 공정은, 구체적으로 플레이트에 고정된 표적 핵산분자에 대상결합 단백질을 포함하는 용액을 흘려보냄으로써 수행한다. 표적 핵산 분자의 고정화는 기존의 여러 가지 고정화 방법을 이용할 수 있는데, 예를 들어 스트렙토아비딘이 코팅된 웰 플레이트에 비오틴 수식한 표적 핵산 분자를 포함하는 핵산 프로브를 제공하여 고정시킬 수 있다.

한편, 측정대상이 되는 후보 단백질은 표지 단백질, 예를 들어 루시퍼라제 등의 효소나 형광 단백질과 융합될 수 있다. 표지 단백질과의 융합으로 검출이나 정량이 보다 간단해진다.

RPB-ELISA법은 Biacore와 같은 특별한 장치를 필요로 하지 않는다는 이점이 있다. 또한, RPB-ELISA법에 의해 스루풋(throughput)이 높고, 단백질과 핵산의 결합을 단기간에 평가할 수 있다. 더욱이 RPB-ELISA법은 실시예의 조건에서는, 6.25nM의 단백질 농도 이상으로 충분히 검출 가능하고, 대장균 용균체에서도 동일하게 검출 가능하기 때문에, 대상으로 하는 핵산 결합성 단백질의 정제를 실시할 필요가 없다는 장점을 가진다.

[PPR 단백질의 이용]

(복합체, 융합 단백질)

본 발명에 의해 제공되는 PPR 모티프 또는 PPR 단백질은 기능성 영역을 연결하여 복합체(complex)로 만들 수 있다. 또한, 단백질성의 기능성 영역(functional region)을 연결하여 융합 단백질(fusion protein)로 제조할 수 있다. 기능성 영역은 생체 내 또는 세포 내에서 특정한 생물학적 기능, 예를 들어 효소기능, 촉매기능, 저해기능, 항진기능 등의 기능을 가지는 부분 또는 표지로서의 기능을 가지는 부분을 의미한다. 예를 들어, 이러한 영역은 단백질, 펩티드, 핵산, 생리활성물질, 약재로 이뤄진다. 또한, 이하에서는 본 발명을 복합체에 관하여 융합 단백질을 예로 들어 설명하였는데, 당업자라면 그 설명에 준하여 융합 단백질 이외의 복합체인 경우에 대해서도 이해할 수 있을 것이다.

본 발명의 바람직한 실시태양의 하나로서, 기능성 영역은 리보핵산 가수분해효소(RNase)이다. RNase의 예로서는 RNase A(예를 들어, bovine pancreatic ribonuclease A: PDB 2AAS), RNase H를 들 수 있다.

또 다른 바람직한 실시태양의 하나로서, 기능성 영역은 형광 단백질이다. 형광 단백질의 예로서는 mCherry, EGFP, GFP, Sirius, EBFP, ECFP, mTurquoise, TagCFP, AmCyan, mTFP1, MidoriishiCyan, CFP, TurboGFP, AcGFP, TagGFP, Azami-Green, ZsGreen, EmGFP, HyPer, TagYFP, EYFP, Venus, YFP, PhiYFP, PhiYFP-m, TurboYFP, ZsYellow, mBanana, KusabiraOrange, mOrange, TurboRFP, DsRed-Express, DsRed2, TagRFP, DsRed-Monomer, AsRed2, mStrawberry, TurboFP602, mRFP 1, JRed, KillerRed, HcRed, KeimaRed, mRasberry, mPlum, PS-CFP, Dendra2, Kaede, EosFP, KikumeGR 등이다. 융합 단백질로서의 응집성 개선 및/또는 핵에 대한 효율적인 국재화(localization)의 관점에서 바람직한 예는 mClover3이다.

또 다른 바람직한 실시태양의 하나로서, 기능성 영역은 표적이 mRNA인 경우 표적 mRNA에서의 단백질 발현량을 향상시키는 기능성 도메인(functional domain)이다(WO 2017/209122). mRNA로부터의 단백질 발현량을 향상시키는 기능성 도메인은, 예를 들면 mRNA의 번역을 직접적 또는 간접적으로 촉진하는 것으로 알려져 있는 단백질의 기능성 도메인의 전부 또는 일부라도 무방하다. 보다 구체적으로, mRNA 리보솜을 유도하는 도메인, mRNA의 번역 시작 또는 번역 촉진과 관련된 도메인, mRNA의 핵 외부로의 수송과 관련된 도메인, 소포체(endoplasmic reticulum, ER) 막으로의 결합과 관련된 도메인, 소포체 보류 신호(ER retention signal) 서열을 포함하는 도메인, 또는 소포체 신호서열을 포함하는 도메인일 수 있다. 좀 더 구체적으로, 상기 mRNA 리보솜을 유도하는 도메인은, DENR(Density-regulated protein), MCT-1(Malignant T-cell amplified sequence 1), TPT1(Translationally-controlled tumor protein), 및 Lerepo4(Zinc finger CCCH-domain)로 이루어진 군에서 선택되는 폴리펩티드의 전부 또는 기능적 부분을 포함하는 도메인일 수 있다. 또한, 상기 mRNA 번역개시 또는 번역촉진에 관련된 도메인은 eIF4E 및 eIF4G로 이루어진 군으로부터 선택되는 폴리펩티드의 전부 또는 기능적인 부분을 포함하는 도메인일 수 있다. 또한, 상기 mRNA 핵 외부로의 수송과 관련된 도메인은 SLBP(Stem-loop binding protein)의 전부 또는 기능적인 부분을 포함하는 도메인일 수 있다. 또한, 상기 소포체막으로의 결합과 관련된 도메인은 SEC61B, TRAP-alpha(Translocon associated protein alpha), SR-alpha, Dia1(Cytochrome b5 reductase 3), 및 p180로 이루어진 군으로부터 선택되는 폴리펩티드의 전부 또는 기능성 부분을 포함하는 도메인일 수 있다. 또한, 상기 소포체 보류 신호(ER retention signal) 서열은 KDEL(서열번호 55) 또는 KEEL(서열번호 56) 서열을 포함하는 신호서열이다. 또한, 상기 소포체 신호서열은 MGWSCIILFLVATATGAHS를 포함하는 신호서열일 수 있다.

본 발명에서의 기능성 영역은 PPR 단백질의 N-말단 측에 융합되어도 좋고, C-말단 측에 융합되어도 좋으며, N-말단 측과 C-말단 측의 양쪽에 융합되어도 무방하다. 또한, 복합체 또는 융합 단백질은 복수의 기능성 영역(예를 들어, 2개 내지 5개)을 포함해도 좋다. 또한, 본 발명의 복합체 또는 융합 단백질은 기능성 영역과 PPR 단백질이 링커 등을 통해 간접적으로 융합되어도 좋다.

(PPR 단백질 등을 암호화하는 핵산, 벡터, 세포)

본 발명은 상술한 PPR 모티프, PPR 단백질 또는 융합 단백질을 암호화하는 핵산, 핵산을 포함하는 벡터(예를 들어, 증폭을 위한 벡터, 발현 벡터)도 제공한다. 증폭을 위한 벡터는 대장균이나 효모를 숙주로 사용할 수 있다. 본 명세서에서 발현 벡터(expression vector)란, 예를 들어 상류에 프로모터 서열을 가지는 DNA, 원하는 단백질을 암호화하는 DNA 및 터미네이터 서열을 가지는 DNA를 포함하는 벡터를 의미하나, 원하는 기능을 발휘하는 한 반드시 이 순서로 서열화되어 있을 필요는 없다. 본 발명에서는 당업자가 통상 사용할 수 있는 여러가지 벡터를 재조합하여 사용할 수 있다.

본 발명에서의 PPR 단백질 또는 융합 단백질은 진핵생물(예를 들어, 동물, 식물, 미생물(효모 등), 원생생물)의 세포로 기능할 수 있다. 본 발명의 융합 단백질은 특히 동물세포 내(실험실 조건 또는 생체 내 조건)에서 기능을 발휘할 수 있다. 본 발명에서의 PPR 단백질 또는 융합 단백질, 또는 이를 발현하는 벡터를 도입할 수 있는 동물세포로는, 예를 들어 사람, 원숭이, 돼지, 소, 말, 개, 고양이, 마우스, 래트 유래의 세포를 들 수 있다. 또한, 본 발명에서의 PPR 단백질, 또는 융합 단백질, 또는 이를 발현하는 벡터를 도입할 수 있는 배양세포로는, 예를 들어 차이니즈 햄스터 난소(CHO) 세포, COS-1 세포, COS-7 세포, VERO(ATCC CCL-81) 세포, BHK 세포, 개의 신장 유래 MDCK 세포, 햄스터 AV-12-664 세포, HeLa 세포, WI38 세포, 293 세포, 293T 세포, PER.C6 세포를 들 수 있지만, 이들에 국한되는 것은 아니다.

(용도)

본 발명에서의 PPR 단백질, 또는 융합 단백질은 생체 내 또는 세포 내에 핵산서열 특이적으로 기능성 영역을 전달하고 기능시킬 수 있다. GFP 등의 마커 부분과 연결된 복합체는 원하는 RNA를 생체 내에서 가시화하기 위해 이용할 수 있다.

또한, 본 발명에서의 PPR 단백질 또는 융합 단백질은 세포 내 또는 생체 내에서 핵산서열 특이적으로 개변, 파괴할 수 있고 새로운 기능을 부여할 수 있다. 특히, RNA 결합성 PPR 단백질은 오르가넬(organelle)에서 볼 수 있는 RNA의 모든 가공 단계, 즉 절단(cleavage), RNA 편집(edition), 번역(translation), 접합(splicing), RNA 안정화(stabilization)에 관여하고 있다. 따라서, 본 발명에 의해 제공되는 PPR 단백질의 개질과 관련된 방법 및 본 발명에 의해 제공되는 PPR 모티프 및 PPR 단백질은 다양한 분야에서 다음과 같은 이용을 기대할 수 있다.

(1) 의료

특정 질환과 관련된 특정 RNA를 인식하고 결합하는 PPR 단백질을 작제한다. 또한, 특정 RNA에 관하여 표적서열을 분석하고 부수되는 단백질을 분석한다. 이들 분석 결과는 질환의 치료를 위한 화합물 탐색에 이용될 수 있다.

예를 들어, 동물에서는 LRPPRC로 일컫어지는 PPR 단백질의 이상이 Leigh syndrome French Canadian type(LSFC; 레이증후군, 아급성 괴사성 뇌척수증)을 일으키는 것으로 알려져 있다. 본 발명은 LSFC의 처치(예방, 치료, 진행 억제)에 기여할 수 있다. 기존의 PPR 단백질의 대부분은 RNA 조작(RNA 상에서의 유전정보 변환; 많은 경우 C→U)의 편집부위의 지정에 작용한다. 이런 타입의 PPR 단백질은 RNA 편집효소와 상호작용할 것으로 예상되는 부가적인 모티프가 C-말단 측에 존재한다. 이러한 구조를 가지는 PPR 단백질로 염기다형(polymorphism)을 도입하거나 염기다형에 기인한 질환 또는 상태를 치료할 수 있을 것으로 기대된다.

·RNA의 억제·발현을 조절하는 세포를 작제한다. 이러한 세포에는 분화, 미분화 상태를 모니터링하는 줄기세포(예를 들어, iPS 세포), 화장품 평가용 모델세포, 신약개발 메커니즘 규명 및 약리시험을 목적으로 기능성 RNA의 발현을 ON/OFF할 수 있는 세포가 포함된다.

- 특정 질환과 관련된 특정 RNA에 특이적으로 결합하는 PPR 단백질을 작제한다. 이러한 PPR 단백질을 플라스미드, 바이러스 벡터, mRNA, 정제 단백질을 이용하여 세포에 도입하고, 그 PPR 단백질이 세포 내에서 표적 RNA와 결합함으로써 질환의 원인인 RNA 기능을 변화(개선)시킬 수 있다. 기능 변화 수단은 예를 들어 결합에 의한 RNA 구조의 변화, 분해(decomposition)에 따른 녹다운, 접합(splicing)에 의한 접합 반응의 변화, 염기치환 등을 들 수 있다.

(2) 농림수산업

·농작물, 임산물, 수산물 등에 있어서, 수량이나 품질을 개선한다.

·내병성의 향상, 환경내성의 향상, 향상되었거나 새로운 기능성을 가지는 생물을 육종한다.

예를 들어, 잡종 제1대(F1) 작물에 관해 PPR 단백질에 의한 미토콘드리아 RNA의 안정화나 번역제어를 사용하여 인공적으로 F1 작물을 만들어 수율이나 품질을 개선할 수 있다. PPR 단백질에 의한 RNA 조작 및 게놈 편집은 이전 기술보다 정확하고 신속하게 생물의 품종 개량, 육종(생물을 유전적으로 개량하는 것)이 가능하다. 또한, PPR 단백질에 의한 RNA 조작과 게놈 편집은 유전자 조작처럼 외래 유전자에 의해 형질을 전환하는 것이 아니라, 원래 동식물이 갖는 RNA나 게놈을 취급하는 기술이라는 점에서, 변이체의 선발이나 되돌림 교잡(backcrossing)이라는 종래의 육종방법에 가깝다고 할 수 있다. 따라서, 전 지구 차원의 식량 문제, 환경 문제에도 확실하고 신속하게 대응할 수 있다.

(3) 화학

미생물, 배양세포, 식물체, 동물체(예를 들면, 곤충)를 이용한 유용물질 생산에서 DNA, RNA의 조작에 의해 단백질 발현량을 제어한다. 이로써, 유용 물질의 생산성을 개선할 수 있다. 유용물질의 예로는 항체, 백신, 효소 등의 단백질성 물질 외에 의약품의 중간체, 향료, 색소 등의 비교적 저분자 화합물이다.

·조류나 미생물의 대사경로 변경에 의해, 바이오 연료의 생산효율을 개선한다.

PPR 유전자의 작제방법 확립

(모티프 설계)

우선, PPR 모티프를 설계하였다. 지금까지 보고된 인공 PPR 단백질에 이용되는 PPR 모티프 서열로는, 다양한 방법으로 추출한 천연계에 존재하는 PPR 모티프 서열의 컨센서스(consensus) 서열이 이용되었다. 이들 중에서도 dPPR(참조: 비특허문헌 2, 3, 및 6)의 모티프 서열을 이용하여 작제된 PPR 단백질은 낮은 Kd 값을 가진다(친화성이 높다). 이하에서는, 이 PPR 모티프 서열을 'v1 PPR 모티프'라 칭하였다.

다른 PPR 모티프 서열로는 각 염기를 인식하는 대표적인 1번, 4번, (ii)번 아미노산 조합을 포함하는 PPR 모티프만을 사용하여 컨센서스 서열을 생성하였다. 구체적으로, 각 염기를 인식하는 대표적인 아미노산 조합으로서, 아데닌(A)을 인식하는 조합은 1번이 발린, 4번이 트레오닌, (ii)번이 아스파라긴; 시토신(C)을 인식하는 조합은 1번이 발린, 4번이 아스파라긴; (ii)번이 세린; 구아닌(G)을 인식하는 조합은 1번이 발린, 4번이 트레오닌 (ii)번이 아스파르트산; 우라실(U)을 인식하는 조합은 1번이 발린, 4번이 아스파라긴, (ii)번이 아스파르트산이므로, 이들의 1번, 4번, (ii)번의 조합을 포함하는 PPR 모티프 서열에서 컨센서스 아미노산 서열을 추출하고, 그 서열을 아데닌, 시토신, 구아닌, 우라실을 각각 특이적으로 인식하는 PPR 모티프 서열로 사용하였다(도 1 내지 4, 서열번호 9 내지 12). 이하에서는, 이를 'v2 PPR 모티프'로 칭하였다. v1 PPR 모티프에서도 같은 1번, 4번, (ii)번 아미노산의 조합을 이용하기로 하였다(서열번호 13 내지 16).

(1개 모티프 및 2개 모티프의 라이브러리를 이용한 심리스(seamless) 클로닝)

이들 설계한 PPR 모티프 서열을 매끄럽게(seamlessly) 연결하는 클로닝 방법을 구축하였다(도 5). 클로닝은 3단계로 진행된다. STEP1에서는 각 모티프 서열의 설계와 작제, STEP2에서는 하나 혹은 두 모티프가 클로닝된 플라스미드 라이브러리의 작제, STEP3에서 필요한 모티프 수를 연결함으로써 목적하는 PPR 유전자가 완성된다.

먼저, 하나의 PPR 모티프 서열(4번부터 (ii)번까지)이 클로닝된 플라스미드를 만들었다(STEP1). STEP1의 플라스미드에는 A, C, G, U 각각을 인식하는 PPR 모티프 서열이 포함된다. 이어지는 STEP2에서는 STEP1 플라스미드 내의 PPR 모티프 서열을 포함하는 DNA 단편을 중간벡터(Dest-x, 서열은 이하)로 클로닝하였다. 1개의 모티프만 삽입 가능한 STEP1 플라스미드는 'P1a-vx-X', 2개의 모티프만 삽입 가능한 플라스미드는 N-말단 측을 'P2a-vx-X', C-말단 측을 'P2b-vx-X'라 각각 칭하였다(vx는 v1 또는 v2, X는 A, C, G, U이다). Dest-x로의 클로닝을 위해 BsaI 제한효소 부위(BsaI 제한효소는 GGTCTCnXXXX 서열(서열번호 17)을 인식절단하고, XXXX 부분이 4개 염기의 돌출말단(protruding end)이 된다(이하에서는, '태그 서열'이라 함)) 및, 매끄럽게(seamlessly) 연결하기 위한 염기서열을 다음과 같이 설계하였다.

각 모티프 서열의 5'-말단 측 및 3'측에

P1a의 경우는 ggtctcaatac (서열번호 18), gtggtgagacc (서열번호 19),

P2a의 경우는 ggtctcaatac (서열번호 18), gtggtcacatatgagacc (서열번호 20),

P2b의 경우는 ggtctcacatac (서열번호 21), gtggtgagacc (서열번호 19)의 서열을 각각 부가한 염기서열을 유전자 합성기술로 작제하여 pUC57-amp로 클로닝하였다.

Dest-x는 Dest-a, b, c, d, e, f, g, h, i, j의 10 종류가 있으며, Dest-a 부터 Dest-j까지 순서대로 매끄럽게 연결되도록 염기서열을 설계하였다.

Dest-a는

gaagacataaactccgtggtcacATACagagaccaaggtctcaGTGGtcacatacatgtcttc (서열번호 1),

Dest-b는 gaagacatATACagagaccaaggtctcaGTGGtgacataatgtcttc (서열번호 22),

Dest-c는 gaagacatcATACagagaccaaggtctcaGTGGttacatatgtcttc (서열번호 23),

Dest-d는 gaagacatacATACagagaccaaggtctcaGTGGttacaatgtcttc (서열번호 24),

Dest-e는 gaagacattacATACagagaccaaggtctcaGTGGtgacatgtcttc (서열번호 25),

Dest-f는 gaagacattgacATACagagaccaaggtctcaGTGGttaatgtcttc (서열번호 26),

Dest-g는 gaagacatgttacATACagagaccaaggtctcaGTGGtcatgtcttc (서열번호 27),

Dest-h는 gaagacatggtcacATACagagaccaaggtctcaGTGGtatgtcttc (서열번호 28),

Dest-i는 gaagacattggttacATACagagaccaaggtctcaGTGGatgtcttc (서열번호 29),

Dest-j는 gaagacatgtggtgacATACagagaccaaggtctcaGTGGtcttc (서열번호 30)

를 유전자 합성기술로 작제하여 pUC57-kan으로 클로닝하였다.

모든 Dest-x에, A, C, G, U에 대응하는 PPR 모티프를 삽입한 것, AA, AC, AG, AU, CA, CC, CG, CU, GA, GC, GG, GU, UA, UC, UG, UU 각각의 염기 조합을 인식하는 2개의 PPR 모티프를 삽입한 것을 작제하여, v1, v2 각각의 STEP1 플라스미드 라이브러리를 만들었다(각각 200종을 포함한다). 상술한 각 조합에서, 40ng의 P1a 플라스미드만, 혹은 40ng의 P2a 플라스미드와 40ng의 P2b 플라스미드를, 0.2μL 10 x 연결효소 완충용액(NEB, B0202S), 0.1μL BsaI(NEB, R0535S), 0.1μL Quick ligase(NEB, M2200S))에 가하고 1.9μL가 되도록 멸균수로 조정하였다. 37℃에서 5분간, 16℃에서 5분간 번갈아 5회 반복하는 반응을 열순환기(thermal cycler, Biorad, 1861096J1)에서 실시하였다. XL1-blue를 2.5μL의 반응액으로 형질전환하고, 30μg/ml의 카나마이신이 함유된 LB 배지에서 선발하였다. 목적하는 서열이 삽입된 것을 서열결정(sequencing)으로 확인하였다.

STEP3에서는 표적 염기서열에 따라 Dest-a 내지 Dest-j를 선택하여, CAP-x 벡터(참조: 비특허문헌 1)에 클로닝하였다. 모든 중간벡터에 1개의 모티프를 포함하는 것을 사용하는 경우에는 10개의 모티프가 연결되고, 2개의 모티프를 포함하는 것을 사용하는 경우에는 20개의 모티프가 연결된다. 11개 내지 19개의 모티프를 포함하는 플라스미드는 바람직한 위치에 1개의 모티프를 포함하는 Dest-x를 사용한다. 예를 들어, 18개 모티프의 PPR 서열을 작제할 때 1개의 모티프를 포함하는 Dest-a 및 Dest-b, 그 외에는 2개의 모티프를 포함하는 플라스미드를 사용한다.

STEP3의 클로닝에서 사용하는 중간벡터는 다음 3종류의 벡터 중에서 선택해야 한다. 가장 C-말단 쪽에 위치한 모티프가 인식하는 염기서열이 아데닌일 경우 CAP-A, 시토신일 경우 CAP-C, 구아닌 또는 우라실일 경우 CAP-GU를 각각 사용한다. STEP3에 사용하는 중간벡터에 클로닝되도록 PPR 반복서열(repeat)의 N-말단 측에 MGNSV(서열번호 31), C-말단 측에 ELTYNTLISGLGLGRARDPPV(서열번호 32)의 아미노산 서열이 부가되도록 설계하였다.

각각 20ng의 10가지 중간 플라스미드, 1μL의 10 x 연결효소 완충용액(NEB, B0202S), 0.5μL의 BpiL(Thermo, ER 1012), 0.5μL의 Quick 연결효소(NEB, M2200S)를 가하고, 멸균수를 가하여 최종 10μL의 부피가 되도록 하였다. 37℃에서 5분간, 16℃에서 7분간, 15사이클 반응시켰다. 이어, 0.4μL의 BpiL을 가하고, 37℃에서 30분간, 75℃에서 6분간 반응시켰다. 이어, 0.3μL의 1mM ATP와 0.15μL의 Plasmid safe nuclease(Epicentre, E3110K)를 가하여, 37℃에서 15분간 반응시켰다. 반응액 3.5μL를 대장균(XL-1 Blue주의 Competent cell, 닛폰진)으로 형질전환하고, 100μg/mL의 스펙티노마이신이 함유된 LB 배지에서 37℃의 온도로 16시간 배양하여 선발하였다. 생성된 콜로니의 일부를 pCR8_Fw:5'-TTGATGCCTGGCAGTTCCCT-3′(서열번호 33)와 pCR8_Rv:5'-CGAACGAACAGCTGT-3′(서열번호 34)의 프라이머를 사용하여 삽입된 유전자 영역을 증폭시키는데 사용하였다. 0.2mL 튜브에 5μL의 2 x Go-taq(Promega, M7123), 1.5μL의 10μM pCR8 Fw, 1.5μL의 10μM pCR8 Rv, 2μL의 멸균수를 가하고, 98℃에서 2분간, 98℃에서 5초간, 55℃에서 10초간, 72℃에서 2.5분간 열순환기에서 반응시켜 증폭반응을 수행하였다. 반응용액의 일부를 MultiNA(SHIMADZU, MCE202)를 이용하여 전기영동하여 삽입된 DNA 조각의 크기를 확인하였다. v1 모티프 또는 v2 모티프를 사용함으로써, 18개 모티프의 PPR 단백질 3종(PPR1, PPR2, PPR3)(서열번호 35 내지 37, 서열번호 40 내지 42)에 대하여 각 3 클론(v1_PPR1, v1_PPR2, v1_PPR3, v2_PPR1, v2_PPR1, v2_PPR3)을 제조하였으며, 그 결과를 도 6의 B에 나타내었다. v1에서는 PPR2의 2번째 클론 이외에는 올바른 크기의 밴드를 얻을 수 있었다. v2에서는 모든 클론에서 올바른 크기의 밴드를 얻을 수 있었다. 또한, 이러한 서열에 대해서는 서열결정으로 확인하였다. 이러한 결과로부터, 이 방법으로 클로닝함으로써 효율적으로 PPR 단백질 유전자를 구축할 수 있음이 밝혀졌다.

고속 대량(high throughput) RNA 결합 단백질 결합능력 평가 시스템의 구축

일반적으로, 핵산결합 단백질과 핵산분자의 결합평가는 EMSA나 Biacore를 이용한 방법에 따라 이루어진다. EMSA(Electrophoretic Mobility Shift Assay)는 단백질과 핵산이 결합된 시료를 전기영동시 핵산분자의 이동도가 결합되지 않은 경우와 비교하여 변화하는 성질을 이용하는 방법이다. 이 방법은 정제 단백질이 필요하다는 점, 조작이 번거롭다는 점과 한 번에 많은 시료를 분석할 수 없다는 결점이 있다. Biacore로 대표되는 분자간 상호작용 분석기기는 반응속도론적 분석이 가능하기 때문에 상세한 단백질-핵산결합 분석이 가능하지만, 이 역시 정제 단백질이 필요하고, 또한 특별한 장치가 필요하다. 따라서, 고속 대량으로 단시간에 단백질과 핵산의 결합을 평가할 수 있는 방법을 고려하게 되었다.

일반적으로, ELISA(Enzyme-Linked Immuno Sorbent Assay)법은 항체(단백질)와 단백질의 결합을 분석할 때 이용된다. 이 방법에서는 1차 항체를 웰 플레이트 상에 고정시키고 거기에 검출하고자 하는 단백질을 포함하는 용액을 첨가하여 세척한 다음, 분석대상인 잔존하는 단백질의 량을 검출하기 위해 발색, 발광검출이 가능한 2차 항체를 반응시켜 정량한다. 이것을 응용하여 핵산분자를 플레이트에 고정하고, 거기에 목적하는 핵산 결합 단백질을 포함하는 용액을 흘려 결합한 단백질량을 정량하는 시스템을 고안하였다(도 7의 A). 조사하고자 하는 핵산분자의 고정방법은 그 말단에 비오틴을 수식한 핵산 프로브를 스트렙토아비딘이 코팅된 웰 플레이트에 가하여 실시한다. 측정하고자 하는 핵산결합 단백질은 루시퍼라제나 형광 단백질과 융합하면 보다 간단하게 검출할 수 있다. 또한, 측정하고자 하는 단백질의 정제는 필수가 아니며 측정하고자 하는 핵산결합 단백질이 발현된 세포(동물 배양세포, 효모, 대장균 등)의 조추출액을 이용하여도 가능하며 정제하기 위한 시간의 단축이 가능하다(도 7의 B). 이 방법에 따라 RNA와 RNA 결합 단백질의 결합을 측정하는 경우, 이하에서는 'RPB-ELISA(RNA-inding protein)'라 칭하였다.

실험 시스템을 확립하기 위하여, 재조합 MS2 단백질과 거기에 결합하는 RNA 프로브를 제조하였다. MS2 단백질의 N-말단 측에 루시퍼라제 단백질, C-말단 측에 6x히스티딘 태그를 융합한 단백질의 유전자를 유전자 합성에 의하여 작제하고 pET21b 벡터로 클로닝하였다(NL_MS 2_HIS, 서열번호 357). RNA 프로브로서, MS2 결합서열을 포함하는 표적 서열(RNA_4, 서열번호 64) 및, 포함하지 않는 비표적 서열(RNA_51, 서열번호 247)의 5＇말단을 비오틴화 수식한 것을 합성하였다(Greiner). MS2 단백질 발현 플라스미드를 Rosetta(DE3)주의 대장균으로 형질전환하고, 100μg/mL 앰피실린이 함유된 2mL LB 배지에서 37℃에서 하룻밤 배양하였다. 그런 다음, 2mL의 배양액을 100μg/mL 앰피실린 함유 300mL LB 배지에 가하고, OD₆₀₀값이 0.5에서 0.8에 이를 때까지 37℃에서 배양하였다. 배양한 배지의 온도를 15℃로 낮춘 후에 최종 농도 0.1mM이 되도록 IPTG를 추가하고 12시간 동안 배양하였다. 5000 x g, 4℃ 조건으로 10분간 배양액을 원심분리하여 균체를 회수하고, 5ml의 용해용 완충용액(20mM Tris-HCl (pH 8.0), 150mM NaCl, 0.5% NP-40, 1mM DTT, 1mM EDTA)을 가한 다음, 혼합물을 볼텍스 믹서기로 교반하고 음파로 파쇄하였다, 음파 파쇄 혼합물을 15,000rpm, 4℃에서 10분간 원심분리하여 상등액을 회수하였다. 상등액의 절반은 대장균 용균체로 사용할 때까지 -80℃에서 보존하고, 나머지는 히스티딘 태그와 Ni-NTA를 이용한 친화성 정제를 실시하였다. 우선, 200μL의 Ni-NTA 아가로스 비드(Qiagen, Cat no. 30230)를 스핀다운하고 비드를 회수하였다. 여기에 세척용 완충용액 100μL를 가하고, 4℃에서 1시간 동안 로테이터로 교반함으로써 비드를 평형화시켰다. 평형화된 비드 전량을 단백질 용액과 혼합하여 4℃에서 1시간 동안 반응시켰다. 이후 2,000rpm, 2분간 원심분리하여 비드를 회수한 후, 10ml의 세척용 완충용액(20mM Tris-HCl, pH 8.0, 500mM NaCl, 0.5% NP-40, 10mM 이미다졸)으로 비드에 비특이적으로 결합하는 인자들을 제거하였다. 용출용 완충용액(20mM Tris-HCl, pH 8.0, 500mM NaCl, 0.5% NP-40, 500mM 이미다졸) 60μL로 용출시킨 다음, 정제도를 SDS-PAGE 방법으로 확인하였다. 용출물을 20mM Tris-HCl, pH 8.0, 150mM NaCl, 0.5% NP-40, 1mM DTT, 1mM EDTA로 4℃에서 하룻밤 투석하였다.

대장균 용균체(E. coli lysate)와 정제 MS2 단백질 용액의 루시퍼라제 발광량을 측정하였다. 발광 완충용액(20mM Tris-HCl(pH 7.6), 150mM NaCl, 5mM MgCl₂, 0.5% NP-40, 1mM DTT)으로 2,500배 희석한 루시퍼라제 기질(Promega, E151A) 40μL와 40μL의 대장균 용균체 또는 40μL의 정제 MS2 단백질 용액을 96 웰 화이트 플레이트에 가해 5분간 반응시킨 후, 발광량을 플레이트 리더(Perkin Elmer, 5103-35)로 측정하였다. 이를 발광량에 기반하여, 0.01 x 10⁸, 0.02 x 10⁸, 0.09 x 10⁸, 0.38 x 10⁸, 1.50 x 10⁸, 6.00 x 10⁸ LU/μL이 되도록 용해용 완충용액(20mM Tris-HCl(pH 7.6), 150mM NaCl, 5mM MgCl₂, 0.5% NP-40, 1 mM DTT, 0.1% BSA)으로 희석하였다.

2.5 pmol 비오틴화 RNA 프로브를 96 웰(well)의 스트렙토아비딘 코팅 화이트 플레이트(Thermo fisher, 15502)에 가하고, 30분간 실온에서 반응시킨 후 용해용 완충용액으로 세정하였다. 백그라운드 측정을 위해 비오틴화 RNA를 가하지 않고 용해용 완충용액을 가한 웰을 준비하였다(-Probe). 그런 다음, 정지용 완충용액(20mM Tris-HCl(pH 7.6), 150mM NaCl, 5mM MgCl₂, 0.5% NP-40, 1mM DTT, 1% BSA)을 가하여 30분간 실온에서 플레이트 표면의 블로킹을 행하였다. 여기에 상기 희석한 대장균 용균체 또는 정제 단백질 용액을 100μL 가하고, 30분간 실온에서 결합반응을 수행하였다. 그런 다음, 200μL의 세척용 완충용액(20mM Tris-HCl(pH 7.6), 150mM NaCl, 5mM MgCl₂, 0.5% NP-40, 1mM DTT)으로 5회 세척하였다. 세척용 완충용액에서 2,500배 희석한 루시퍼라제 기질(Promega, E151A) 40μL를 웰에 가하여 5분간 반응시킨 후, 발광량을 플레이트 리더(Perkin Elmer, 5103-35)로 측정하였다.

각각의 RNA와 MS2 단백질을 포함하는 용액을 가한 시료의 발광량으로부터, 백그라운드(RNA를 가하지 않고 PPR 단백질을 가하였을 때의 발광 신호값)를 공제한 값을 MS2 단백질과 RNA의 결합력으로 하였다.

그 결과를 도 7의 C에 나타내었다. 정제 단백질 용액("Purified protein"), 대장균 용균체("Lysate") 모두 MS2 단백질과 표적 RNA(Target seq.)와의 특이적 결합이 검출되었다. 6.0 x 10⁸LU/μL는 100nM 정제 MS2 단백질에 상당하므로, 6.25nM (0.38 x 10⁸ LU/μL)의 단백질 농도 이상으로 충분히 검출이 가능한 것으로 밝혀졌다. 또한, 대장균 용균체에서도 마찬가지로 검출이 가능하여, 단백질을 정제할 필요가 없는 것으로 밝혀졌다.

기존 PPR 모티프 서열 또는 신규한 PPR 모티프 서열을 이용하여 작제한 18개 모티프 PPR 단백질의 RNA 결합능력 비교 실험

v1 또는 v2 PPR 모티프를 사용하여 작제한 PPR 단백질의 RNA 결합능력을 평가하기 위해 대장균으로 재조합 단백질을 제조하고, RPB-ELISA법을 사용하여 결합능력을 평가하였다. 비교를 위해 5종의 표적서열(T_1, T_2, T_3, T_4, T_5, 서열번호 46 내지 50)을 설정하고, 각각에 결합하는 PPR 단백질을 설계하여 각각을 암호화하는 유전자를 작제하였다(v1_PPR1, v1_PPR2, v1_PPR3, v1_PPR4, v1_PPR5, v2_PPR1, v2_PPR2, v2_PPR3, v2_PPR4, v2_PPR5, 서열번호 35 내지 39, 서열번호 40 내지 45). 작제한 PPR 유전자의 N-말단 측에 루시퍼라제 단백질 유전자, C-말단 측에 His-태그 배열을 부가하여 pET21 벡터로 클로닝하였다(NL v1 PPR1, NL v1 PPR2, NL v1 PPR3, NL v1 PPR4, NL v1 PPR5, NL v2 PPR1, NL v2 PPR2, NL v2 PPR3, NL v2 PPR4, NL v2 PPR5, 서열번호 51 내지 60). PPR 발현 플라스미드를 Rosetta(DE3)주로 형질전환하였다. 대장균을 2mL의 100μg/mL 앰피실린이 함유된 LB 배지에서 37℃, 12시간의 조건으로 배양하고, OD₆₀₀값이 0.5 내지 0.8에 도달하였을 때 15℃의 배양기로 배양액을 옮겨 30분간 정치시켰다. 그런 다음, 100μL(최종농도 0.1mM IPTG)를 가하고, 15℃에서 16시간 동안 배양하였다. 5,000 x g, 4℃의 조건으로 10분간 원심분리하여 대장균 펠렛을 회수하고, 1.5mL의 용해용 완충용액(20mM Tris-HCl, pH 8.0, 150mM NaCl, 0.5% NP-40, 1mM MgCl₂, 2mg/mL 리소자임, 1mM PMSF, 2μL의 10mg/mL DNase)을 가하고, -80℃에서 20분간 동결시켰다. 25℃에서 30분간 침투시키면서 세포를 동결 파쇄(cryodisruption)시켰다. 이어, 3,700rpm, 4℃의 조건으로 15분간 원심분리하여, 가용성 PPR 단백질을 포함하는 상등액(대장균 용균체)을 회수하였다.

표적서열 18개 염기를 포함하는 30개 염기의 서열을 설계하고, 그 5'-말단을 비오틴화 수식한 RNA 프로브(RNA_1, RNA_2, RNA_3, RNA_4, RNA_5, 서열번호 61 내지 65)를 합성한 다음, 그 5'-말단을 비오틴화 RNA를 스트렙토아비딘 코팅 플레이트(Thermo fisher)에 가하여 30분간 실온에서 반응시키고, 용해용 완충용액(20mM Tris-HCl, pH 7.6, 150mM NaCl, 5mM MgCl₂, 0.5% NP-40, 1mM DTT, 0.1% BSA)으로 세척하였다. 백그라운드 측정을 위하여 RNA를 가하지 않고, 100μL 용해용 완충용액과 1μL 100mM DTT와 1μL 40unit/μL RNase inhibitor(Takara, 2313A)를 가한 웰도 준비하였다. 그런 다음, 200μL 정지용 완충용액(20mM Tris-HCl, pH 7.6, 150mM NaCl, 5mM MgCl₂, 0.5% NP-40, 1mM DTT, 1% BSA)을 가하고 30분간 실온에서 플레이트 표면을 블로킹시켰다. 그런 다음, 1.5 x 10⁸LU/μL의 발광량을 가지는 루시퍼라제 융합 PPR 단백질이 포함된 대장균 용균체를 100μL 가하고, 실온에서 30분간 결합반응을 실시하였다. 그 후, 200μL의 세척용 완충용액(20mM Tris -HCl, pH 7.6, 150mM NaCl, 5mM MgCl₂, 0.5% NP-40, 1mM DTT)으로 5회 세척하였다. 세척용 완충용액으로 2,500배 희석한 루시퍼라제 기질(Promega, E151A) 40μL를 웰에 가하여 5분간 반응시킨 후, 발광량을 플레이트 리더(Perkin Elmer, 5103-35)로 측정하였다. 각각의 RNA와 PPR 단백질을 가한 시료의 발광량에서 백그라운드 신호(RNA를 첨가하지 않고 PPR 단백질을 가하였을 때의 발광 신호 값)을 뺀 값을 PPR과 RNA의 결합력으로 하였다.

그 결과를 도 8에 나타내었다. 모티프 서열 v2로 작제하는 경우, 모티프 서열 v1로 작제한 것과 비교하여 모두 표적서열과의 결합력의 증가(1.3배 내지 3.6배)를 볼 수 있었다. 또한, 표적이 아닌 서열을 가지는 RNA 프로브를 2종류 준비하여(off target 1, off target 2)(서열번호 66 및 69), 그것들에 대한 결합을 조사한 결과, v2로 작제한 경우가 v1로 작제한 경우보다 표적 결합 신호/비표적 결합 신호(S/N)이 높았다(도 8의 좌상단).

따라서, v2가 v1보다 친화성도 높아 표적에 대한 특이성이 높은 것으로 나타났다.

v2 모티프를 사용하여 작제한 PPR 단백질의 RNA 결합능력 상세 분석

(특이성 평가)

v2 모티프를 사용하여 23종의 표적서열(T_1 내지 T_3, T_5 내지 T_24, 서열번호 46 내지 48, 서열번호 51 내지 69)에 대한 PPR 단백질을 작제(NL_v2_PPR1~3, NL_v2_PPR5~24, 서열번호 46 내지 48, 서열번호 51 내지 69)하고, RPB-ELISA법을 이용하여 모든 조합의 결합을 분석하였다. 실험방법은 실시예 3과 같다.

그 결과를 도 9(상단)에 나타내었다. v2_17과 v2_24를 제외한 21종의 PPR 단백질로 표적에 대한 결합력이 가장 강한 것으로 나타났다. 이러한 결과로부터, v2의 모티프를 이용하면 PPR 단백질을 안정적으로 작제할 수 있고, 결합 특이성이 높음을 알 수 있었다.

v3.1 모티프를 사용하여 동일한 23종의 표적서열에 대한 PPR 단백질을 동일하게 작제하였으며(염기서열은 서열번호 411 내지 433, 아미노산 서열은 서열번호 434 내지 456), RPB-ELISA법을 사용하여 모든 조합의 결합을 분석하였다. 실험방법은 실시예 3과 같다.

그 결과를 도 9(하단) 및 다음 표 10에 나타내었다. v2보다 결합력이 향상된 것을 얻을 수 있었다.

또한, 도 9에 나타낸 PPR 단백질의 RNA 결합능력을 수치(log2 값)로 이하의 표에 나타내었다.

(친화성 평가)

아울러, 각 PPR 단백질의 표적 RNA에 대한 친화성(Kd 값)을 산출하기 위해 EMSA를 실시하였다. 상술한 23종 중 10종의 PPR 단백질을 암호화하는 유전자 서열의 N-말단 측에 스트렙토아비딘 결합 펩티드 서열, C-말단 측에 6x His-태그 서열을 부가하여 대장균 발현 플라스미드를 구축하였다(SBP v2 PPR1 HIS, SBP v2 PPR2 HIS, SBP v2 PPR3 HIS, SBP v2 PPR6 HIS, SBP v2 PPR9 HIS, SBP v2 PPR12 HIS, SBP v2 PPR15 HIS, SBP v2 PPR16 HIS, SBP v2 PPR20 HIS, SBP v2 PPR24 HIS, 서열번호 89 내지 97). Rosetta(DE3)주의 대장균으로 형질전환하고, 2mL의 100μg/mL 앰피실린 함유 LB 배지에서 37℃ 하룻밤 배양하였다. 그런 다음, 2mL의 배양액을 300ml의 100μg/mL 앰피실린이 함유된 LB 배지로 옮기고, OD₆₀₀값이 0.5 내지 0.8에 이를 때까지 37℃에서 배양하였다. 배양한 배지를 15℃로 낮춘 후에 0.1mM의 IPTG를 가하고 12시간 동안 배양하였다. 5000 x g, 4℃의 조건으로 10분간 배양액을 원심분리하여 균체를 회수하고, 5ml의 용해용 완충용액(20mM Tris-HCl, pH 8.0, 150mM NaCl, 0.5% NP-40, 1mM DTT, 1mM EDTA)을 가하고 볼텍스 믹서기로 교반한 후, 음파(sonication)로 균체를 파쇄하였다. 그런 다음, 15,000rpm, 4℃의 조건으로 10분간 원심분리하여 상등액을 회수하였다.

이어, SBP 태그(SBP tag)를 이용한 친화성 크로마토그래피로 목적하는 단백질을 정제하였다. Streptavidine Sepharose High Performance(GE Healthcare, 17511301) 100μL를 취하여 스핀 다운(spin down)으로 비드(bead)를 회수한 후, 세척용 완충용액(20mM Tris-HCl, pH 8.0, 500mM NaCl, 0.5% NP-40)으로 평형화된 비드를 방금 회수한 세포 추출액과 조심스럽게 혼합하여 10분간 4℃에서 침투시켰다. 이어, 컬럼에 이 비드 용액 전량을 공여하고, 세척용 완충용액 10mL로 비드를 세정하였다. 용출용 완충용액(20mM Tris-HCl, pH 8.0, 500mM NaCl, 2mM 비오틴)으로 용출시켰다.

다음으로, 히스티딘 태그(histidine tag)를 이용한 친화성 정제(affinity purification)를 실시하였다. 먼저, 200μL의 Ni-NTA 아가로스(Qiagen, 30230)를 회수하고 원심분리하여 비드를 회수하였다. 세척용 완충용액을 100μL 가하고 4℃에서 1시간 동안 침투시킴으로써 비드를 평형화하였다. 평형화된 비드 전량을 SBP 비드에서 용출된 단백질 용액과 혼합하여, 4℃에서 1시간 동안 반응시켰다. 그 후 2,000rpm으로 2분간 원심분리하여 비드를 회수한 후, 10ml의 세척용 완충용액(20mM Tris-HCl, pH 8.0, 500mM NaCl, 0.5% NP-40, 10mM 이미다졸)으로 비드에 비특이적으로 결합하는 인자를 제거하였다. 용출용 완충용액(20mM Tris-HCl, pH 8.0, 500mM NaCl, 0.5% NP-40, 500mM 이미다졸) 60μL로 용출시키고, 정제도를 SDS-PAGE에서 확인하였다. (20mM Tris-HCl, pH 8.0, 150mM NaCl, 0.5% NP-40, 1mM DTT, 1mM EDTA)로 4회 하룻밤 투석을 하였다.

Pierce 660nm Protein Assay Kit(Thermo fisher, 22662)를 사용하여 투석 후 단백질 총량을 측정하였다. 다음으로, 목적 단백질의 량을 측정하기 위하여 투석한 시료를 10% 폴리아크릴아미드겔에서 SDS-PAGE하고 CBB 염색을 하였다. ChemiDoc Touch MP 이미징 시스템(Biorad)으로 염색 후 겔 이미지를 취하였다. 이 겔 화상으로부터 전체 밴드(total band) 강도와 목적 밴드(objective band)의 강도를 측정하였다. 목적하는 단백질의 량은 전체 밴드의 강도에서 목적 밴드의 비율에 총 단백질량을 곱하여 산출하였다. 이 값을 이용해서 투석 시료의 정제 단백질의 몰 농도를 산출하였다. 위에서 구한 몰 농도를 바탕으로, 400nM, 200nM, 100nM, 50nM, 20nM, 10nM, 5nM, 2nM, 1nM의 희석 단백질 용액을 조정하였다. 이때, 결합용 완충용액(20mM Tris-HCl, pH 8.0, 150mM NaCl, 0.5% NP-40, 1mM DTT, 1mM EDTA)을 이용하여 희석하였다. 5'-말단 측이 비오틴화 수식된 RNA 프로브(RNA_1, RNA_2, RNA_3, RNA_6, RNA_9, RNA_12, RNA_15, RNA_16, RNA_20, RNA_24)를 결합용 완충용액으로 최종농도 20nM이 되도록 조정하였다. 75℃에서 1분간 열처리한 후에 급랭한 RNA 시료를 다음 실험에 이용하였다.

위에서 조정한 각 농도의 단백질 용액에 20nM의 RNA 프로브 용액을 혼합하여 25℃에서 20분간 결합반응을 수행하였다.

반응 후 2μL의 80% 글리세롤을 첨가하여 잘 현탁한 후, 그 10μL를 ATTO 7.5% 겔에 공여하고 전기영동을 C.V. 150V에서 30분간 실시하였다.

전기영동 후 겔을 Hybond N+ 막(GE, RPN203B)으로 전사하였다. 이어서 ASTEC Dual UV Transiluminator UVA-15(Astec, 49909-06)를 이용하여 RNA를 막에 UV 가교시켰다. 상기 막을 정지용 완충용액(6.7mM NaH₂PO₄·2H₂O, 6.7mM Na₂HPO₄·2H₂O, 125mM NaCl, 5% SDS)으로 블로킹하였다. 이때 Stereptavidine-HRP(Abcam, ab7403) 0.5μL를 정지용 완충용액에 미리 넣어 두고, 15분간 침투시키면서 항원항체 반응을 실시하였다. 정지용 완충용액을 버리고 세척용 완충용액(0.67mM NaH₂PO₄·2H₂O, 0.67mM Na₂HPO₄·2H₂O, 12.5mM NaCl, 0.5% SDS)을 20ml 가하여 막을 세척하였다. 이어, 이러한 세척조작을 5회 반복한 후에 평형화 완충용액(100mM Tris-HCl, pH 9.5, 100mM NaCl, 10mM MgCl₂)을 20ml 가하고 막을 5분간 침투시켰다. 그런 다음, Immunobilon Western Chemiluminisecnet HRP Substrate(Millipore, Cat No. WBKLS0100)를 막에 가하여, 비오틴화 RNA를 화학발광(chemiluminescence)시켜 밴드를 검출하였다. ChemiDoc Touch MP 이미징 시스템(Biorad)에서 겔 화상을 도입하였다. 결합하지 않은 RNA 프로브의 밴드와 단백질과 결합함으로써 전환한 밴드의 밴드강도를 산출하였다. 단백질의 몰 농도와 그에 대응하는 시프트밴드의 비율로 Hill식(Hill equation)에 적용시킴으로써 평형해리승수(Kd 값)를 산출하였다.

그 결과를 도 10에 나타내었다. 작제된 PPR 단백질은 표적에 대해 Kd 값은 10^-9내지 10^-7M을 갖는 것으로 밝혀졌다. 최소치(높은 친화성)는 1.95 x 10^-9 이었는데, 지금까지 보고된 설계 PPR 단백질 중에서는 가장 Kd 값이 낮다(표 1 참조). 또한, 이러한 Kd 값은 RPB-ELISA에서의 결합실험으로 얻은 신호 값과 상관하는 것이 밝혀졌다(R2 = -0.85). 이러한 결과로부터, RPB-ELISA에서의 발광치가 1~2 x 10⁷ 인 경우에는 Kd 값이 10^-6 내지 10^-7 M, RPB-ELISA에서의 발광치가 2~4 x 10⁷ 인 경우에는 Kd 값이 10^-7 내지 10^-8 M, RPB-ELISA에서의 발광치가 4 x 10⁷ 보다 큰 경우에는 Kd 값이 ~ 10^-8 이하인 것으로 추정할 수 있었다.

(구축 성공률의 평가)

아울러, 72종의 표적서열(T1~T3, T6~T76, 서열번호 46 내지 48, 서열번호 51 내지 69, 서열번호 117 내지 168)에 대한 PPR 단백질을 v2 모티프를 사용하여 작제(NL_v2_PPR1~3, NL_v2_PPR6~76, 서열번호 56 내지 58, 서열번호 70 내지 88, 서열번호 169 내지 220)하고, RPB-ELISA법을 이용하여 구축 성공 확률을 산출하였다. 표적서열을 포함하는 비오틴화 RNA 프로브(RNA_1 내지 3, RNA_6 내지 76, 서열번호 61 내지 63, 서열번호 98 내지 116, 서열번호 221 내지 272)와 비표적서열(T51, 서열번호 143)을 포함하는 비오틴화 RNA 프로브(RNA_51, 서열번호 247)를 제작하였다(Greinar). 실험방법은 실시예 3과 동일하였고, 그 결과를 도 11에 나타내었다.

72개의 PPR 단백질 중 Kd 값이 10^-6 M이하(RPB-ELISA 값이 1 x 10⁷ 이상)로 추정되는 것은 63개(88%)이고, Kd 값이 10^-7 M이하(RPB-ELISA 값이 2 x 10⁷ 이상)로 추정되는 것은 57개(79%)이며, Kd 값이 10^-8 M 이하(RPB-ELISA 값이 4 x 10⁷ 이상)로 추정되는 것은 43개(40%)였다. 또한, 표적 결합 신호를 비표적 결합 신호로 나눈 값을 특이성을 평가하는 값(S/N)으로 하였는바, 그 S/N 값이 10보다 높은 것은 54개(75%)였고, S/N 값이 100보다 높은 것은 23개(32%)였다. 이러한 결과로부터, v2 모티프를 사용하여 PPR 단백질을 제조함으로써, 효율적으로 서열특이적 RNA 결합 단백질을 제조할 수 있음을 알 수 있었다.

(PPR 모티프의 개수에 관련된 표적 결합활성의 평가)

　 PPR 모티프 개수와 표적 결합활성에 관련성을 분석하였다. 13종의 18개 염기의 표적서열을 설정하고, 그 서열의 5'-말단 측 3개의 염기, 6개의 염기를 각각 제거한 15개의 염기(T_1a, T_49a, T_3a, T_14a, T_40a, T_12a, T_13a, T_2a, T_38a, T_37a, T_39a, T_56a, T_68a, 서열번호 273, 275, 277, 279, 281, 283, 285, 287, 289, 291, 293, 395, 297), 12개의 염기(T_1b, T_49b, T_3b, T_14b, T_40b, T_12b, T_13b, T_2b, T_38b, T_37b, T_39b, T_56b, T_68b, 서열번호 274, 276, 278, 280, 282, 284, 286, 288, 290, 292, 294, 296, 298)의 표적서열을 설정하였다. 그들에 대응하는 PPR 단백질(15개 모티프는 PPRxa, 12개 모티프는 PPRxb로 각각 명명)를 작제하였다(NL_v2_PPR1, 1a, 1b;NL_v2_PPR49, 49a, 49b;NL_v2_PPR3, 3a, 3b;NL_v2_PPR14, 14a, 14b;NL_v2_PPR40, 40a, 40b;NL_v2_PPR12, 12a, 12b;NL_v2_PPR13, 13a, 13b;NL_v2_PPR2, 2a, 2b;NL_v2_PPR38, 38a, 38b;NL_v2_PPR37, 37a, 37b;NL_v2_PPR39, 39a, 39b;NL_v2_PPR56, 56a, 56b;NL_v2 _PPR68, 68a, 68b; 서열번호 56, 299 내지 324). RPB-ELISA에 의한 분석을 위하여 표적서열을 포함하는 비오틴화 RNA 프로브(T_1, T_49, T_3, T_14, T_12, T_13, T_2, T_38, T_37, T_39, T_56, T_68)와, 비표적서열(T_51, 서열번호 143)을 포함하는 비오틴화 RNA 프로브(RNA_51, 서열번호 247)를 작제하여 표적(on target), 비표적(off target)과 각 PPR 단백질과의 결합활성을 RPB-ELISA로 분석하였다.

　 각 표적서열별 결과를 도 12의 A에 나타내었다. 18개 모티프, 15개 모티프, 12개 모티프 각각의 값의 평균치를 상자수염도(box-and-whisker diagram)로 플롯한 결과를 도 12의 B에 나타내었다. 모티프 수가 많을수록 결합강도가 높아져, 18개 모티프와 15개 모티프를 비교하면, 18개 모티프가 높은 결합강도를 가지는 단백질이 안정적으로 작제될 수 있음을 알 수 있었다.

PPR 단백질에 의한 인위적인 접합 제어

PPR 단백질이 세포 내에서 표적 RNA 분자에 결합하여 목적으로 하는 RNA를 조작할 수 있음을 증명하기 위하여, 접합 리포터(splicing reporter)를 이용한 실험을 실시하였다(도 13의 A). 접합 리포터(RG6)는 엑손 1, 인트론 1, 엑손 2, 인트론 2, 엑손 3와 같은 유전자 구조를 취하고 있다(참조: Orengo et al., 2006 NAR). 인트론 1, 엑손 2 및 인트론 2에는 치킨(chicken) cTNT의 인트론 4, 인트론 5 및 인공적으로 작제된 얼터너티브 엑손 서열(alternative exon sequence)이 삽입되었다. 본 리포터는 2개의 접합 폼(splicing form)을 가지고 있으며, 엑손 2가 스킵된 mRNA, 스킵되지 않은 mRNA의 양의 비율이 1:1 정도로 되어 있다. 또한, 엑손 3에는 RFP와 GFP 유전자가 암호화되어 있으나, 엑손 2의 존재, 비존재에 따라 리딩 프레임이 바뀜으로써 엑손 2가 건너뛴(with skip) mRNA에서는 RFP가 발현되고 건너뛰지 않는(without skip) mRNA에서는 GFP가 발현된다. 이 리포터의 접합 폼의 양은 인트론 1, 엑손 2, 인트론 2의 영역으로 결합하는 접합인자(splicing factor)에 의해 제어되고 있음이 알려져 있다(참조: Orengo et al., 2006 NAR). 이에, 인트론 1, 엑손 2, 인트론 2의 영역 중 18개의 염기서열을 선택하고, 이들에 결합하는 PPR 단백질에 의해 RG-6 리포터의 접합 폼을 변화시킬 수 있는지 실험하였다.

RG6 리포터에서 7종의 표적서열(T77~T83, 서열번호 325 내지 330)을 선택하였다. PPR 단백질 유전자는 v1 모티프, v2 모티프 모두로 설계하였다(v1 PPRsp1~6, v2 PPRsp1~6, 서열번호 331 내지 342). PPR 단백질 유전자의 N-말단 측에 핵국재 신호(nuclear localization signal), C-말단 측에 FLAG 에피토프 태그 서열(epitope tag sequence)을 융합한 단백질이 발현되도록 pcDNA3.1에 클로닝하였다(NLS_v1PPRsp1 내지 6, NLS_v2PPRsp1 내지 6, 서열번호 343 내지 354). pcDNA3.1은 CMV 프로모터와 SV40 폴리 A 신호(터미네이터)를 갖는데, 이들 사이에 PPR 단백질 유전자를 삽입하였다.

HEK293T 세포를 9ml의 DMEM, 1ml의 FBS가 함유된 10cm 디쉬에 1 x 10⁶ cells/well의 밀도로 파종하였다. 37℃, 5% CO₂ 조건으로 2일간 배양한 후, 세포를 회수하였다. 회수한 세포를 PLL 코팅된 96웰 플레이트로 웰 당 4 x 10⁴ cells/well로 파종하고, 37℃, 5% CO₂ 조건으로 1일간 배양하였다. 100ng PPR 발현 플라스미드 DNA, 100ng RG-6, 0.6μL Fugene(등록상표)-HD(Promega, E2311), 200μL Opti-MEM을 혼합하고, 전량 웰에 가하여 37℃, 5% CO₂ 조건으로 2일간 배양하였다. 대조구로서 PPR 발현 플라스미드 DNA를 추가하지 않은 시료도 조제하였다. 배양 후 각 웰의 GFP 형광 및 RFP 형광 화상을 형광 현미경 DMi8(Leica)로 취득하였다. 촬영 조건은, 우선 RG-6 플라스미드만을 도입한 시료를 이용하고, GFP와 RFP의 강도가 같은 정도가 되는 노광 시간(exposure time), 게인(gain)을 결정해 그것과 같은 조건으로 각 시료의 형광 화상을 획득하였다.

화상을 얻은 후, Maxwell(등록상표) RSC simplyRNA Cells Kit를 이용하여 총세포 RNA를 추출하였다. 추출한 총세포 RNA 500ng, 0.5μL 100μM dT20 primer, 0.5μL 10mM dNTPs를 0.2mL 튜브에 넣고, 65℃에서 5분간 방치한 후 즉시 빙랭하였다. 여기에 2μL 5x RT-완충용액(Invitrogen, 18080-051), 0.5μL 0.1M DTT, 0.5μL 40U/μL RNase OUT(Invitrogen, 18080-051), 0.5μL 200 unit/μL Supper Script III(Invitrogen, 18080-051)를 가하고, 열순환기(thermal cycler)에서 50℃에서 50분간 반응시킨 다음, 85℃의 온도에서 5분간 반응시키고 16℃로 냉각시켰다. 이것을 2μL의 반응 혼합물, 10μL의 5x GXL 완충용액(TAKARA, R050A), 4μL의 2.5mM dNTPs 1.5μL의 10μM RT-FW 프라이머(5’-CAAAGTGGAGGACCCAGTACC-3’) (서열번호 355), 1.5μL의 10μM RT-Rv 프라이머(5’-GCGCATGAACTCCTTGATGAC-3’) (서열번호 356), 1μL의 GXL (TAKARA, R050A), 31.5μL의 멸균수를 0.2mL 튜브에 넣고, 열순환기로 98℃에서 2분간 반응시킨 다음, 98℃에서 10초, 58℃에서 15초, 68℃에서 5초를 35회 반복한 후 12℃까지 냉각시켰다. 반응액을 10배 희석하여 MultiNA(SHIMADZU, MCE202)에서 전기영동시켰다. 114bp 부근의 밴드를 엑손 스킵한 RNA의 밴드, 142bp 부근의 밴드를 스킵하지 않은 RNA의 밴드로 하여 각 시료의 밴드 강도를 산출하였다. 114bp 밴드 강도를, 114bp 밴드 강도와 142bp 밴드 강도의 총합으로 나눈 값을 접합율(splicing ratio)로 규정하였다.

그 결과를 도 13의 B, 도 13의 C에 제시하였다. RG6 리포터만을 도입하였을 때에는 접합율은 0.48이었으며, PPRsp4를 도입하였을 경우에는 같은 정도였지만, 다른 PPR을 도입하였을 경우에는 크게 변화함을 알 수 있었다. v1과 v2를 비교하면 PPRsp4를 제외하고, v2가 더 크게 변화하였다. 이들 접합율은 도 13의 B에 나타낸 RFP, GFP 발현비와도 일치하였다. 이러한 점에서 PPR 단백질을 이용함으로써 엑손 스키핑을 변화시킬 수 있음이 증명되었으며, v2 모티프를 이용함으로써 보다 효율적으로 접합을 변화시킬 수 있음을 알 수 있었다.

PPR 단백질 응집 제어

v2 모티프를 이용한 PPR 단백질(염기서열은 서열번호 457, 아미노산 서열은 서열번호 458)과 v3.2 모티프를 이용한 PPR 단백질(염기서열은 서열번호 459, 아미노산 서열은 서열번호 460) 각각을 대장균 발현계로 제조하여 정제하고, 겔여과 크로마토그래피로 분리하였다.

(단백질의 발현·정제)

목적으로 하는 PPR 단백질을 암호화하는 DNA 서열을 포함하는 pE-SUMOpro Kan 플라스미드를 이용하여 대장균 Rosetta주를 형질전환시켜 37℃에서 배양한 다음, OD₆₀₀값이 0.6에 이르렀을 때 20℃로 온도를 낮추어 최종농도 0.5mM이 되도록 IPTG를 가하여 목적하는 PPR 단백질을 SUMO 융합 단백질로 하여 대장균 내에서 발현시켰다. 하룻밤 배양 후 균체를 원심분리하여 집균하고, 용혈용 완충용액(50mM Tris-HCl pH 8.0, 500mM NaCl)에 재현탁시켰다. 초음파 파쇄를 통해 대장균을 파쇄하여 17,000g에서 30분간 원심분리한 상등액 분획을 Ni-Agarose 컬럼에 공여하고 20mM 이미다졸을 함유하는 용혈용 완충용액으로 컬럼을 세척한 다음, 400mM 이미다졸을 함유하는 용혈용 완충용액으로 SUMO 융합목적 PPR 단백질을 용출시켰다. 용출 후 Ulp1에 의한 SUMO 단백질을 목적 PPR 단백질에서 떼어내는 동시에, 투석(dialysis)에 의해 단백질 용액을 이온교환 완충용액(50mM Tris-HCl pH 8.0, 200mM NaCl)으로 치환하였다. 그런 다음, SP 컬럼을 이용한 양이온 교환 크로마토그래피를 실시하였다. 컬럼 공여 후 NaCl 농도를 200mM에서 1M까지 서서히 높임으로써 단백질을 용출시켰다. 목적하는 PPR 단백질을 포함하는 분획을 Superdex200 컬럼을 이용한 겔여과 크로마토그래피로 최종 정제하였다. 겔여과 완충용액(25mM HEPES pH 7.5, 200mM NaCl, 0.5mM tris(2-carboxyethyl)phosphine(TCEP))으로 평형화한 겔여과 컬럼에, 이온교환에서 용출된 목적 PPR 단백질을 공여하였다. 끝으로, 목적하는 PPR 단백질을 포함하는 분획을 농축하여 액체 질소로 동결하고, 다음 분석에 사용할 때까지 -80℃에서 보존하였다.

(겔여과 크로마토그래피)

정제한 재조합 PPR 단백질을 농도 1mg/ml로 조정하였다. 겔여과 크로마토그래피는 Superdex 200 increase 10/300 GL(GE Healthcare)을 이용하였다. 25mM HEPES pH 7.5, 200mM NaCl, 0.5mM tris(2-carboxyethyl)phosphine(TCEP)으로 평형화된 겔여과 컬럼에, 상기 농도 조정한 단백질을 적용하고 겔여과 컬럼에서 용출되는 용액을 280nm의 흡광도를 측정함으로써, 단백질의 성질을 분석하였다.

(결과)

결과를 도 14에 나타내었다. 용출분획(Elution vol.)이 적을수록 분자 크기가 크다. v2에서는 8mL 내지 10mL의 용출분획으로 용출된 반면, v3.2에서는 12mL 내지 14mL의 용출분획에 피크가 나타났다. 이러한 결과로부터, v2에서는 단백질 크기가 커지고 있다는 점에서 응집하고 있을 가능성이 시사되며, 그 응집은 v3.2에서 개선되고 있음을 알 수 있었다.

SEQUENCE LISTING <110> EditForce Inc. Kyushu University <120> Methods for Efficiently Producing PPR Proteins and Use thereof <130> F20688K <150> US JP2019-100551 <151> 2019-05-29 <160> 460 <170> PatentIn version 3.5 <210> 1 <211> 35 <212> PRT <213> Artificial Sequence <220> <221> misc_feature <222> (1)..(1) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (4)..(4) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (34)..(34) <223> Xaa can be any naturally occurring amino acid <400> 1 Xaa Thr Tyr Xaa Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu 1 5 10 15 Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val 20 25 30 Pro Xaa Val 35 <210> 2 <211> 35 <212> PRT <213> Artificial Sequence <220> <221> misc_feature <222> (1)..(1) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (4)..(4) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (34)..(34) <223> Xaa can be any naturally occurring amino acid <400> 2 Xaa Thr Tyr Xaa Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 1 5 10 15 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 20 25 30 Pro Xaa Val 35 <210> 3 <211> 35 <212> PRT <213> Artificial Sequence <220> <221> misc_feature <222> (1)..(1) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (4)..(4) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (34)..(34) <223> Xaa can be any naturally occurring amino acid <400> 3 Xaa Thr Tyr Xaa Thr Leu Ile Asp Gly Leu Ala Lys Ala Gly Arg Leu 1 5 10 15 Glu Glu Ala Leu Gln Leu Phe Gln Glu Met Lys Glu Lys Gly Val Lys 20 25 30 Pro Xaa Val 35 <210> 4 <211> 35 <212> PRT <213> Artificial Sequence <220> <221> misc_feature <222> (1)..(1) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (4)..(4) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (34)..(34) <223> Xaa can be any naturally occurring amino acid <400> 4 Xaa Thr Tyr Xaa Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 1 5 10 15 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 20 25 30 Pro Xaa Val 35 <210> 5 <211> 35 <212> PRT <213> Artificial Sequence <400> 5 Val Thr Tyr Asn Ile Leu Ile Lys Gly Leu Cys Lys Ala Gly Lys Leu 1 5 10 15 Glu Glu Ala Leu Ser Leu Leu Ser Glu Met Val Glu Lys Gly Ile Gln 20 25 30 Pro Asp Val 35 <210> 6 <211> 35 <212> PRT <213> Artificial Sequence <400> 6 Val Thr Tyr Asn Thr Leu Ile Ser Gly Phe Cys Lys Ala Gly Arg Leu 1 5 10 15 Glu Glu Ala Met Ser Leu Phe Ser Glu Met Lys Ser Lys Gly Leu Val 20 25 30 Pro Ser Val 35 <210> 7 <211> 35 <212> PRT <213> Artificial Sequence <400> 7 Val Thr Tyr Thr Thr Leu Ile Asp Ala Phe Cys Arg Lys Gly Arg Leu 1 5 10 15 Asp Glu Ala Leu Ser Leu Phe Ser Glu Met Lys Ser Lys Gly Ile Lys 20 25 30 Pro Asn Val 35 <210> 8 <211> 35 <212> PRT <213> Artificial Sequence <400> 8 Val Thr Tyr Thr Ile Leu Ile Asp Ala Leu Cys Lys Ala Gly Arg Leu 1 5 10 15 Glu Glu Ala Leu Ser Leu Phe Ser Glu Met Lys Glu Ile Gly Ile Lys 20 25 30 Pro Asp Val 35 <210> 9 <211> 35 <212> PRT <213> Artificial Sequence <400> 9 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 1 5 10 15 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 20 25 30 Pro Asn Val 35 <210> 10 <211> 35 <212> PRT <213> Artificial Sequence <400> 10 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 1 5 10 15 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 20 25 30 Pro Ser Val 35 <210> 11 <211> 35 <212> PRT <213> Artificial Sequence <400> 11 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 1 5 10 15 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 20 25 30 Pro Asp Val 35 <210> 12 <211> 35 <212> PRT <213> Artificial Sequence <400> 12 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 1 5 10 15 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 20 25 30 Pro Asp Val 35 <210> 13 <211> 35 <212> PRT <213> Artificial Sequence <400> 13 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 1 5 10 15 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 20 25 30 Pro Asn Val 35 <210> 14 <211> 35 <212> PRT <213> Artificial Sequence <400> 14 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 1 5 10 15 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 20 25 30 Pro Ser Val 35 <210> 15 <211> 35 <212> PRT <213> Artificial Sequence <400> 15 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 1 5 10 15 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 20 25 30 Pro Asp Val 35 <210> 16 <211> 35 <212> PRT <213> Artificial Sequence <400> 16 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 1 5 10 15 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 20 25 30 Pro Asp Val 35 <210> 17 <211> 7 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (7)..(7) <223> n is a, c, g, t or u <400> 17 ggtctcn 7 <210> 18 <211> 11 <212> DNA <213> Artificial Sequence <400> 18 ggtctcaata c 11 <210> 19 <211> 11 <212> DNA <213> Artificial Sequence <400> 19 gtggtgagac c 11 <210> 20 <211> 18 <212> DNA <213> Artificial Sequence <400> 20 gtggtcacat atgagacc 18 <210> 21 <211> 12 <212> DNA <213> Artificial Sequence <400> 21 ggtctcacat ac 12 <210> 22 <211> 47 <212> DNA <213> Artificial Sequence <400> 22 gaagacatat acagagacca aggtctcagt ggtgacataa tgtcttc 47 <210> 23 <211> 47 <212> DNA <213> Artificial Sequence <400> 23 gaagacatca tacagagacc aaggtctcag tggttacata tgtcttc 47 <210> 24 <211> 47 <212> DNA <213> Artificial Sequence <400> 24 gaagacatac atacagagac caaggtctca gtggttacaa tgtcttc 47 <210> 25 <211> 47 <212> DNA <213> Artificial Sequence <400> 25 gaagacatta catacagaga ccaaggtctc agtggtgaca tgtcttc 47 <210> 26 <211> 47 <212> DNA <213> Artificial Sequence <400> 26 gaagacattg acatacagag accaaggtct cagtggttaa tgtcttc 47 <210> 27 <211> 47 <212> DNA <213> Artificial Sequence <400> 27 gaagacatgt tacatacaga gaccaaggtc tcagtggtca tgtcttc 47 <210> 28 <211> 47 <212> DNA <213> Artificial Sequence <400> 28 gaagacatgg tcacatacag agaccaaggt ctcagtggta tgtcttc 47 <210> 29 <211> 47 <212> DNA <213> Artificial Sequence <400> 29 gaagacattg gttacataca gagaccaagg tctcagtgga tgtcttc 47 <210> 30 <211> 45 <212> DNA <213> Artificial Sequence <400> 30 gaagacatgt ggtgacatac agagaccaag gtctcagtgg tcttc 45 <210> 31 <211> 5 <212> PRT <213> Artificial Sequence <400> 31 Met Gly Asn Ser Val 1 5 <210> 32 <211> 22 <212> PRT <213> Artificial Sequence <400> 32 Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 1 5 10 15 Ala Arg Asp Pro Pro Val 20 <210> 33 <211> 20 <212> DNA <213> Artificial Sequence <400> 33 ttgatgcctg gcagttccct 20 <210> 34 <211> 20 <212> DNA <213> Artificial Sequence <400> 34 cgaaccgaac aggcttatgt 20 <210> 35 <211> 415 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (48)..(48) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (70)..(70) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (75)..(75) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (136)..(136) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (158)..(158) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (163)..(163) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (185)..(185) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (207)..(207) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (229)..(229) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (251)..(251) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (273)..(273) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (295)..(295) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (400)..(400) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (403)..(403) <223> n is a, c, g, t or u <400> 35 mgnsvvtytt dgckagkdak mvkgkdvvty ttdgckagkd akmvkgknvv tyttdgckag 60 kdakmvkgkn vvtyntdgck agkdakmvkg kdvvtyttdg ckagkdakmv kgkdvvtytt 120 dgckagkdak mvkgknvvty ttdgckagkd akmvkgknvv tyntdgckag kdakmvkgks 180 vvtyntdgck agkdakmvkg kdvvtyntdg ckagkdakmv kgksvvtynt dgckagkdak 240 mvkgkdvvty ntdgckagkd akmvkgkdvv tyntdgckag kdakmvkgks vvtyntdgck 300 agkdakmvkg ksvvtyttdg ckagkdakmv kgkdvvtytt dgckagkdak mvkgkdvvty 360 ttdgckagkd akmvkgkdvv tyttdgckag kdakmvkgkn tyntsggkag rardv 415 <210> 36 <211> 415 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (48)..(48) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (92)..(92) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (158)..(158) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (180)..(180) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (207)..(207) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (229)..(229) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (251)..(251) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (312)..(312) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (356)..(356) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (383)..(383) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (403)..(403) <223> n is a, c, g, t or u <400> 36 mgnsvvtytt dgckagkdak mvkgkdvvty ttdgckagkd akmvkgknvv tyttdgckag 60 kdakmvkgkd vvtyttdgck agkdakmvkg knvvtyttdg ckagkdakmv kgkdvvtytt 120 dgckagkdak mvkgkdvvty ttdgckagkd akmvkgknvv tyttdgckag kdakmvkgkn 180 vvtyttdgck agkdakmvkg kdvvtyntdg ckagkdakmv kgksvvtynt dgckagkdak 240 mvkgksvvty ntdgckagkd akmvkgkdvv tyttdgckag kdakmvkgkd vvtyttdgck 300 agkdakmvkg knvvtyttdg ckagkdakmv kgkdvvtytt dgckagkdak mvkgknvvty 360 ttdgckagkd akmvkgkdvv tyntdgckag kdakmvkgkd tyntsggkag rardv 415 <210> 37 <211> 415 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (9)..(9) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (31)..(31) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (92)..(92) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (119)..(119) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (141)..(141) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (180)..(180) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (185)..(185) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (224)..(224) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (246)..(246) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (251)..(251) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (273)..(273) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (312)..(312) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (339)..(339) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (361)..(361) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (383)..(383) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (403)..(403) <223> n is a, c, g, t or u <400> 37 mgnsvvtynt dgckagkdak mvkgksvvty ntdgckagkd akmvkgkdvv tyttdgckag 60 kdakmvkgkd vvtyttdgck agkdakmvkg knvvtyttdg ckagkdakmv kgkdvvtynt 120 dgckagkdak mvkgkdvvty ntdgckagkd akmvkgksvv tyttdgckag kdakmvkgkn 180 vvtyntdgck agkdakmvkg kdvvtyttdg ckagkdakmv kgknvvtytt dgckagkdak 240 mvkgknvvty ntdgckagkd akmvkgksvv tyntdgckag kdakmvkgks vvtyttdgck 300 agkdakmvkg knvvtyttdg ckagkdakmv kgkdvvtynt dgckagkdak mvkgksvvty 360 ntdgckagkd akmvkgksvv tyntdgckag kdakmvkgkd tyntsggkag rardv 415 <210> 38 <211> 415 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (9)..(9) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (48)..(48) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (53)..(53) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (114)..(114) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (180)..(180) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (185)..(185) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (207)..(207) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (246)..(246) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (251)..(251) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (273)..(273) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (295)..(295) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (334)..(334) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (339)..(339) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (383)..(383) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (403)..(403) <223> n is a, c, g, t or u <400> 38 mgnsvvtynt dgckagkdak mvkgksvvty ttdgckagkd akmvkgknvv tyntdgckag 60 kdakmvkgkd vvtyttdgck agkdakmvkg kdvvtyttdg ckagkdakmv kgknvvtytt 120 dgckagkdak mvkgkdvvty ttdgckagkd akmvkgkdvv tyttdgckag kdakmvkgkn 180 vvtyntdgck agkdakmvkg kdvvtyntdg ckagkdakmv kgksvvtytt dgckagkdak 240 mvkgknvvty ntdgckagkd akmvkgksvv tyntdgckag kdakmvkgks vvtyntdgck 300 agkdakmvkg ksvvtyttdg ckagkdakmv kgknvvtynt dgckagkdak mvkgkdvvty 360 ttdgckagkd akmvkgkdvv tyntdgckag kdakmvkgkd tyntsggkag rardv 415 <210> 39 <211> 415 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (53)..(53) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (92)..(92) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (114)..(114) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (136)..(136) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (158)..(158) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (180)..(180) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (224)..(224) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (229)..(229) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (251)..(251) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (290)..(290) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (295)..(295) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (317)..(317) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (361)..(361) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (400)..(400) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (403)..(403) <223> n is a, c, g, t or u <400> 39 mgnsvvtytt dgckagkdak mvkgkdvvty ttdgckagkd akmvkgkdvv tyntdgckag 60 kdakmvkgks vvtyttdgck agkdakmvkg knvvtyttdg ckagkdakmv kgknvvtytt 120 dgckagkdak mvkgknvvty ttdgckagkd akmvkgknvv tyttdgckag kdakmvkgkn 180 vvtyttdgck agkdakmvkg kdvvtyttdg ckagkdakmv kgknvvtynt dgckagkdak 240 mvkgkdvvty ntdgckagkd akmvkgksvv tyttdgckag kdakmvkgkn vvtyntdgck 300 agkdakmvkg ksvvtyntdg ckagkdakmv kgkdvvtytt dgckagkdak mvkgkdvvty 360 ntdgckagkd akmvkgkdvv tyttdgckag kdakmvkgkn tyntsggkag rardv 415 <210> 40 <211> 423 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (52)..(52) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (77)..(77) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (82)..(82) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (145)..(145) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (170)..(170) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (175)..(175) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (196)..(196) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (216)..(216) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (237)..(237) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (257)..(257) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (277)..(277) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (298)..(298) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (408)..(408) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (411)..(411) <223> n is a, c, g, t or u <400> 40 mgnsvvtytt dgckagkvda dmkrgkdvvt yttdgckagd vdakmrskgv knvvtyttdg 60 ckagdvdakm rskgvknvvt yntdgckagr damkgkdvvt yttdgckagk vdadmkrgkd 120 vvtyttdgck agdvdakmrs kgvknvvtyt tdgckagdvd akmrskgvkn vvtyntdgck 180 sgkakkmkgt svvtyntdgc kagrdamkgk dvvtyntdgc ksgkakkmkg tsvvtyntdg 240 ckagrdamkg kdvvtyntdg ckagrdamkg kdvvtyntdg cksgkakkmk gtsvvtyntd 300 gcksgkakkm kgtsvvtytt dgckagkvda dmkrgkdvvt yttdgckagk vdadmkrgkd 360 vvtyttdgck agkvdadmkr gkdvvtyttd gckagdvdak mrskgvknty ntsggkagra 420 rdv 423 <210> 41 <211> 435 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (52)..(52) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (100)..(100) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (171)..(171) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (196)..(196) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (224)..(224) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (245)..(245) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (266)..(266) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (329)..(329) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (377)..(377) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (405)..(405) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (423)..(423) <223> n is a, c, g, t or u <400> 41 mgnsvvtytt dgckagkvda dmkrgkdvvt yttdgckagd vdakmrskgv knvvtyttdg 60 ckagkvdadm krgkdvvtyt tdgckagdvd akmrskgvkn vvtyttdgck agkvdadmkr 120 gkdvvtyttd gckagkvdad mkrgkdvvty ttdgckagdv dakmrskgvk nvvtyttdgc 180 kagdvdakmr skgvknvvty ttdgckagkv dadmkrgkdv vtyntdgcks gkakkmkgts 240 vvtyntdgck sgkakkmkgt svvtyntdgc kagrdamkgk dvvtyttdgc kagkvdadmk 300 rgkdvvtytt dgckagdvda kmrskgvknv vtyttdgcka gkvdadmkrg kdvvtyttdg 360 ckagdvdakm rskgvknvvt yttdgckagk vdadmkrgkd vvtyntdgck agrdamkgkd 420 tyntsggkag rardv 435 <210> 42 <211> 419 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (9)..(9) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (30)..(30) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (93)..(93) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (121)..(121) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (141)..(141) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (182)..(182) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (187)..(187) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (227)..(227) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (252)..(252) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (257)..(257) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (278)..(278) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (319)..(319) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (347)..(347) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (368)..(368) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (389)..(389) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (407)..(407) <223> n is a, c, g, t or u <400> 42 mgnsvvtynt dgcksgkakk mkgtsvvtyn tdgckagrda mkgkdvvtyt tdgckagkvd 60 admkrgkdvv tyttdgckag dvdakmrskg vknvvtyttd gckagkvdad mkrgkdvvty 120 ntdgckagrd amkgkdvvty ntdgcksgka kkmkgtsvvt yttdgckagd vdakmrskgv 180 knvvtyntdg ckagrdamkg kdvvtyttdg ckagdvdakm rskgvknvvt yttdgckagd 240 vdakmrskgv knvvtyntdg cksgkakkmk gtsvvtyntd gcksgkakkm kgtsvvtytt 300 dgckagdvda kmrskgvknv vtyttdgcka gkvdadmkrg kdvvtyntdg cksgkakkmk 360 gtsvvtyntd gcksgkakkm kgtsvvtynt dgckagrdam kgkdtyntsg gkagrardv 419 <210> 43 <211> 421 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (9)..(9) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (50)..(50) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (55)..(55) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (118)..(118) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (189)..(189) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (194)..(194) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (214)..(214) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (255)..(255) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (260)..(260) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (281)..(281) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (302)..(302) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (343)..(343) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (348)..(348) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (391)..(391) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (409)..(409) <223> n is a, c, g, t or u <400> 43 mgnsvvtynt dgcksgkakk mkgtsvvtyt tdgckagdvd akmrskgvkn vvtyntdgck 60 agrdamkgkd vvtyttdgck agkvdadmkr gkdvvtyttd gckagdvdak mrskgvknvv 120 tyttdgckag kvdadmkrgk dvvtyttdgc kagkvdadmk rgkdvvtytt dgckagdvda 180 kmrskgvknv vtyntdgcka grdamkgkdv vtyntdgcks gkakkmkgts vvtyttdgck 240 agdvdakmrs kgvknvvtyn tdgcksgkak kmkgtsvvty ntdgcksgka kkmkgtsvvt 300 yntdgcksgk akkmkgtsvv tyttdgckag dvdakmrskg vknvvtyntd gckagrdamk 360 gkdvvtyttd gckagkvdad mkrgkdvvty ntdgckagrd amkgkdtynt sggkagrard 420 v 421 <210> 44 <211> 434 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (55)..(55) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (96)..(96) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (121)..(121) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (146)..(146) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (171)..(171) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (196)..(196) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (244)..(244) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (249)..(249) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (269)..(269) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (310)..(310) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (315)..(315) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (336)..(336) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (379)..(379) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (419)..(419) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (422)..(422) <223> n is a, c, g, t or u <400> 44 mgnsvvtytt dgckagkvda dmkrgkdvvt yttdgckagk vdadmkrgkd vvtyntdgck 60 sgkakkmkgt svvtyttdgc kagdvdakmr skgvknvvty ttdgckagdv dakmrskgvk 120 nvvtyttdgc kagdvdakmr skgvknvvty ttdgckagdv dakmrskgvk nvvtyttdgc 180 kagdvdakmr skgvknvvty ttdgckagkv dadmkrgkdv vtyttdgcka gdvdakmrsk 240 gvknvvtynt dgckagrdam kgkdvvtynt dgcksgkakk mkgtsvvtyt tdgckagdvd 300 akmrskgvkn vvtyntdgck sgkakkmkgt svvtyntdgc kagrdamkgk dvvtyttdgc 360 kagkvdadmk rgkdvvtynt dgckagrdam kgkdvvtytt dgckagdvda kmrskgvknt 420 yntsggkagr ardv 434 <210> 45 <211> 427 <212> DNA <213> Artificial Sequence <220> <221> misc_feature <222> (3)..(3) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (9)..(9) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (50)..(50) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (75)..(75) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (80)..(80) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (121)..(121) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (126)..(126) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (146)..(146) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (187)..(187) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (215)..(215) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (235)..(235) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (256)..(256) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (319)..(319) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (324)..(324) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (364)..(364) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (389)..(389) <223> n is a, c, g, t or u <220> <221> misc_feature <222> (415)..(415) <223> n is a, c, g, t or u <400> 45 mgnsvvtynt dgcksgkakk mkgtsvvtyt tdgckagdvd akmrskgvkn vvtyttdgck 60 agdvdakmrs kgvknvvtyn tdgcksgkak kmkgtsvvty ttdgckagdv dakmrskgvk 120 nvvtyntdgc kagrdamkgk dvvtyntdgc ksgkakkmkg tsvvtyttdg ckagdvdakm 180 rskgvknvvt yttdgckagk vdadmkrgkd vvtyntdgck agrdamkgkd vvtyntdgck 240 sgkakkmkgt svvtyntdgc kagrdamkgk dvvtyttdgc kagkvdadmk rgkdvvtytt 300 dgckagdvda kmrskgvknv vtyntdgcka grdamkgkdv vtyttdgcka gdvdakmrsk 360 gvknvvtytt dgckagdvda kmrskgvknv vtyttdgcka gkvdadmkrg kdtyntsggk 420 agrardv 427 <210> 46 <211> 18 <212> DNA <213> Artificial Sequence <400> 46 gaaugaacuc uuccggga 18 <210> 47 <211> 18 <212> DNA <213> Artificial Sequence <400> 47 gagaggaagc cugagagu 18 <210> 48 <211> 18 <212> DNA <213> Artificial Sequence <400> 48 cugagucaua accagccu 18 <210> 49 <211> 18 <212> DNA <213> Artificial Sequence <400> 49 caugaggauc acccaugu 18 <210> 50 <211> 18 <212> DNA <213> Artificial Sequence <400> 50 ggcaaaaaga ucacugua 18 <210> 51 <211> 18 <212> DNA <213> Artificial Sequence <400> 51 caacaucagu cugauaag 18 <210> 52 <211> 18 <212> DNA <213> Artificial Sequence <400> 52 cacaaugugg ccgaggac 18 <210> 53 <211> 18 <212> DNA <213> Artificial Sequence <400> 53 aagccaguuu ucauuuug 18 <210> 54 <211> 18 <212> DNA <213> Artificial Sequence <400> 54 cacuauuuaa guuaucaa 18 <210> 55 <211> 18 <212> DNA <213> Artificial Sequence <400> 55 caaacuuuca cuuugaaa 18 <210> 56 <211> 18 <212> DNA <213> Artificial Sequence <400> 56 gguggugagg cccugggc 18 <210> 57 <211> 18 <212> DNA <213> Artificial Sequence <400> 57 gacucaggaa ucggcucu 18 <210> 58 <211> 18 <212> DNA <213> Artificial Sequence <400> 58 caacaucaaa gacaccau 18 <210> 59 <211> 18 <212> DNA <213> Artificial Sequence <400> 59 gucagagggu ucuggauu 18 <210> 60 <211> 18 <212> DNA <213> Artificial Sequence <400> 60 gcagauaauu aauaagaa 18 <210> 61 <211> 18 <212> DNA <213> Artificial Sequence <400> 61 aaggauaaua ucaaacac 18 <210> 62 <211> 18 <212> DNA <213> Artificial Sequence <400> 62 uuaucagacu gauguuga 18 <210> 63 <211> 18 <212> DNA <213> Artificial Sequence <400> 63 gguuagagau acagugug 18 <210> 64 <211> 18 <212> DNA <213> Artificial Sequence <400> 64 gugggggugg uaggaaau 18 <210> 65 <211> 18 <212> DNA <213> Artificial Sequence <400> 65 gugaugugga guuaaggc 18 <210> 66 <211> 18 <212> DNA <213> Artificial Sequence <400> 66 ggaagagugu cuggagca 18 <210> 67 <211> 18 <212> DNA <213> Artificial Sequence <400> 67 ugaugaugau gaugauga 18 <210> 68 <211> 18 <212> DNA <213> Artificial Sequence <400> 68 ucuuugccau uucccaua 18 <210> 69 <211> 18 <212> DNA <213> Artificial Sequence <400> 69 cccauagaug ugacaagc 18 <210> 70 <211> 869 <212> PRT <213> Artificial Sequence <400> 70 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 71 <211> 869 <212> PRT <213> Artificial Sequence <400> 71 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 72 <211> 869 <212> PRT <213> Artificial Sequence <400> 72 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 73 <211> 869 <212> PRT <213> Artificial Sequence <400> 73 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 725 730 735 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 740 745 750 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 74 <211> 869 <212> PRT <213> Artificial Sequence <400> 74 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 75 <211> 869 <212> PRT <213> Artificial Sequence <400> 75 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 76 <211> 869 <212> PRT <213> Artificial Sequence <400> 76 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 690 695 700 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 705 710 715 720 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 770 775 780 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 77 <211> 869 <212> PRT <213> Artificial Sequence <400> 77 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 690 695 700 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 705 710 715 720 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 725 730 735 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 740 745 750 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 78 <211> 869 <212> PRT <213> Artificial Sequence <400> 78 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 79 <211> 869 <212> PRT <213> Artificial Sequence <400> 79 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 80 <211> 869 <212> PRT <213> Artificial Sequence <400> 80 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 725 730 735 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 740 745 750 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 81 <211> 869 <212> PRT <213> Artificial Sequence <400> 81 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 82 <211> 869 <212> PRT <213> Artificial Sequence <400> 82 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 83 <211> 869 <212> PRT <213> Artificial Sequence <400> 83 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 84 <211> 869 <212> PRT <213> Artificial Sequence <400> 84 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 85 <211> 869 <212> PRT <213> Artificial Sequence <400> 85 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 770 775 780 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 86 <211> 869 <212> PRT <213> Artificial Sequence <400> 86 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 87 <211> 869 <212> PRT <213> Artificial Sequence <400> 87 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 450 455 460 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 690 695 700 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 705 710 715 720 Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 88 <211> 869 <212> PRT <213> Artificial Sequence <400> 88 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 89 <211> 731 <212> PRT <213> Artificial Sequence <400> 89 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 65 70 75 80 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 85 90 95 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 100 105 110 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 115 120 125 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 130 135 140 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 145 150 155 160 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 180 185 190 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 210 215 220 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 245 250 255 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 260 265 270 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 275 280 285 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 290 295 300 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 305 310 315 320 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 325 330 335 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 355 360 365 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 385 390 395 400 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 420 425 430 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 435 440 445 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 450 455 460 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 465 470 475 480 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 485 490 495 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 500 505 510 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 515 520 525 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 530 535 540 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 565 570 575 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 595 600 605 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 625 630 635 640 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 645 650 655 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 660 665 670 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 675 680 685 Asn Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 90 <211> 731 <212> PRT <213> Artificial Sequence <400> 90 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 65 70 75 80 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 85 90 95 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 100 105 110 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 115 120 125 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 130 135 140 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 145 150 155 160 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 180 185 190 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 210 215 220 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 245 250 255 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 260 265 270 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 275 280 285 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 290 295 300 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 305 310 315 320 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 325 330 335 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 355 360 365 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 385 390 395 400 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 420 425 430 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 435 440 445 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 450 455 460 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 465 470 475 480 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 485 490 495 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 500 505 510 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 515 520 525 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 530 535 540 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 565 570 575 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 595 600 605 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 625 630 635 640 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 645 650 655 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 660 665 670 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 675 680 685 Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 91 <211> 731 <212> PRT <213> Artificial Sequence <400> 91 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Asn 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 65 70 75 80 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 85 90 95 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 100 105 110 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 115 120 125 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 130 135 140 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 145 150 155 160 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 180 185 190 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 210 215 220 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 245 250 255 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 260 265 270 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 275 280 285 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 290 295 300 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 305 310 315 320 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 325 330 335 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 355 360 365 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 385 390 395 400 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 420 425 430 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 435 440 445 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 450 455 460 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 465 470 475 480 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 485 490 495 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 500 505 510 Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 515 520 525 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 530 535 540 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 565 570 575 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 595 600 605 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 625 630 635 640 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 645 650 655 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 660 665 670 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 675 680 685 Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 92 <211> 731 <212> PRT <213> Artificial Sequence <400> 92 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Asn 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 65 70 75 80 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 85 90 95 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 100 105 110 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 115 120 125 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 130 135 140 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 145 150 155 160 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 180 185 190 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 210 215 220 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 245 250 255 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 260 265 270 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 275 280 285 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 290 295 300 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 305 310 315 320 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 325 330 335 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 355 360 365 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 385 390 395 400 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 420 425 430 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 435 440 445 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 450 455 460 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 465 470 475 480 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 485 490 495 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 500 505 510 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 515 520 525 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 530 535 540 Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 565 570 575 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 595 600 605 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 625 630 635 640 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 645 650 655 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 660 665 670 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 675 680 685 Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 93 <211> 731 <212> PRT <213> Artificial Sequence <400> 93 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Asn 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 65 70 75 80 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 85 90 95 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 100 105 110 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 115 120 125 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 130 135 140 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 145 150 155 160 Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 180 185 190 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 210 215 220 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 245 250 255 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 260 265 270 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 275 280 285 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 290 295 300 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 305 310 315 320 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 325 330 335 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 355 360 365 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 385 390 395 400 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 420 425 430 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 435 440 445 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 450 455 460 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 465 470 475 480 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 485 490 495 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 500 505 510 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 515 520 525 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 530 535 540 Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 565 570 575 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 595 600 605 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 625 630 635 640 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 645 650 655 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 660 665 670 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 675 680 685 Asn Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 94 <211> 731 <212> PRT <213> Artificial Sequence <400> 94 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 65 70 75 80 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 85 90 95 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 100 105 110 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 115 120 125 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 130 135 140 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 145 150 155 160 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 180 185 190 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 210 215 220 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 245 250 255 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 260 265 270 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 275 280 285 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 290 295 300 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 305 310 315 320 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 325 330 335 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 355 360 365 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 385 390 395 400 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 420 425 430 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 435 440 445 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 450 455 460 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 465 470 475 480 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 485 490 495 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 500 505 510 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 515 520 525 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 530 535 540 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 565 570 575 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 595 600 605 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 625 630 635 640 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 645 650 655 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 660 665 670 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 675 680 685 Asn Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 95 <211> 731 <212> PRT <213> Artificial Sequence <400> 95 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 65 70 75 80 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 85 90 95 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 100 105 110 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 115 120 125 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 130 135 140 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 145 150 155 160 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 180 185 190 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 210 215 220 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 245 250 255 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 260 265 270 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 275 280 285 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 290 295 300 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 305 310 315 320 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 325 330 335 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 355 360 365 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 385 390 395 400 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 420 425 430 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 435 440 445 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 450 455 460 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 465 470 475 480 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 485 490 495 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 500 505 510 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 515 520 525 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 530 535 540 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 565 570 575 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 595 600 605 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 625 630 635 640 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 645 650 655 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 660 665 670 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 675 680 685 Ser Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 96 <211> 731 <212> PRT <213> Artificial Sequence <400> 96 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 65 70 75 80 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 85 90 95 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 100 105 110 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 115 120 125 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 130 135 140 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 145 150 155 160 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 180 185 190 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 210 215 220 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 245 250 255 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 260 265 270 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 275 280 285 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 290 295 300 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 305 310 315 320 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 325 330 335 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 355 360 365 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 385 390 395 400 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 420 425 430 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 435 440 445 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 450 455 460 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 465 470 475 480 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 485 490 495 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 500 505 510 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 515 520 525 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 530 535 540 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 565 570 575 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 595 600 605 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 625 630 635 640 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 645 650 655 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 660 665 670 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 675 680 685 Ser Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 97 <211> 731 <212> PRT <213> Artificial Sequence <400> 97 Met Ala Gly Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 1 5 10 15 Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 20 25 30 His Pro Gln Gly Gln Arg Glu Pro Gly Gly Ser Gly Gly His Met Gly 35 40 45 Ser Gly Gly Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Asn 50 55 60 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 65 70 75 80 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 85 90 95 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 100 105 110 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 115 120 125 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 130 135 140 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 145 150 155 160 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 165 170 175 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 180 185 190 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 195 200 205 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 210 215 220 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 225 230 235 240 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 245 250 255 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 260 265 270 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 275 280 285 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 290 295 300 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 305 310 315 320 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 325 330 335 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 340 345 350 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 355 360 365 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 370 375 380 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 385 390 395 400 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 405 410 415 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 420 425 430 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 435 440 445 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 450 455 460 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 465 470 475 480 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 485 490 495 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 500 505 510 Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 515 520 525 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 530 535 540 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 545 550 555 560 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 565 570 575 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 580 585 590 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 595 600 605 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 610 615 620 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 625 630 635 640 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 645 650 655 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 660 665 670 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 675 680 685 Ser Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 690 695 700 Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly His His His His His His Gly Arg 725 730 <210> 98 <211> 30 <212> DNA <213> Artificial Sequence <400> 98 gacaugccaa caucagucug auaaggacug 30 <210> 99 <211> 30 <212> DNA <213> Artificial Sequence <400> 99 gacaugccac aauguggccg aggacgacug 30 <210> 100 <211> 30 <212> DNA <213> Artificial Sequence <400> 100 gacaugcaag ccaguuuuca uuuuggacug 30 <210> 101 <211> 30 <212> DNA <213> Artificial Sequence <400> 101 gacaugccac uauuuaaguu aucaagacug 30 <210> 102 <211> 30 <212> DNA <213> Artificial Sequence <400> 102 gacaugccaa acuuucacuu ugaaagacug 30 <210> 103 <211> 30 <212> DNA <213> Artificial Sequence <400> 103 gacaugcggu ggugaggccc ugggcgacug 30 <210> 104 <211> 30 <212> DNA <213> Artificial Sequence <400> 104 gacaugcgac ucaggaaucg gcucugacug 30 <210> 105 <211> 30 <212> DNA <213> Artificial Sequence <400> 105 gacaugccaa caucaaagac accaugacug 30 <210> 106 <211> 30 <212> DNA <213> Artificial Sequence <400> 106 gacaugcguc agaggguucu ggauugacug 30 <210> 107 <211> 30 <212> DNA <213> Artificial Sequence <400> 107 gacaugcgca gauaauuaau aagaagacug 30 <210> 108 <211> 30 <212> DNA <213> Artificial Sequence <400> 108 gacaugcaag gauaauauca aacacgacug 30 <210> 109 <211> 30 <212> DNA <213> Artificial Sequence <400> 109 gacaugcuua ucagacugau guugagacug 30 <210> 110 <211> 30 <212> DNA <213> Artificial Sequence <400> 110 gacaugcggu uagagauaca guguggacug 30 <210> 111 <211> 30 <212> DNA <213> Artificial Sequence <400> 111 gacaugcgug ggggugguag gaaaugacug 30 <210> 112 <211> 30 <212> DNA <213> Artificial Sequence <400> 112 gacaugcgug auguggaguu aaggcgacug 30 <210> 113 <211> 30 <212> DNA <213> Artificial Sequence <400> 113 gacaugcgga agagugucug gagcagacug 30 <210> 114 <211> 30 <212> DNA <213> Artificial Sequence <400> 114 gacaugcuga ugaugaugau gaugagacug 30 <210> 115 <211> 30 <212> DNA <213> Artificial Sequence <400> 115 gacaugcucu uugccauuuc ccauagacug 30 <210> 116 <211> 30 <212> DNA <213> Artificial Sequence <400> 116 gacaugcccc auagauguga caagcgacug 30 <210> 117 <211> 18 <212> DNA <213> Artificial Sequence <400> 117 gugaagguga cagcaguc 18 <210> 118 <211> 18 <212> DNA <213> Artificial Sequence <400> 118 cgggccuccg guguucug 18 <210> 119 <211> 18 <212> DNA <213> Artificial Sequence <400> 119 cuuaucagac ugauguug 18 <210> 120 <211> 18 <212> DNA <213> Artificial Sequence <400> 120 acguggauga aguuggug 18 <210> 121 <211> 18 <212> DNA <213> Artificial Sequence <400> 121 agcuuaucag acugaugu 18 <210> 122 <211> 18 <212> DNA <213> Artificial Sequence <400> 122 gcuuaucaga cugauguu 18 <210> 123 <211> 18 <212> DNA <213> Artificial Sequence <400> 123 cauguucgaa uucguuuu 18 <210> 124 <211> 18 <212> DNA <213> Artificial Sequence <400> 124 ugcugggcaa ggugaacg 18 <210> 125 <211> 18 <212> DNA <213> Artificial Sequence <400> 125 uagcuuauca gacugaug 18 <210> 126 <211> 18 <212> DNA <213> Artificial Sequence <400> 126 uuuuauugug cuauggca 18 <210> 127 <211> 18 <212> DNA <213> Artificial Sequence <400> 127 uccucaccgg ugacuggu 18 <210> 128 <211> 18 <212> DNA <213> Artificial Sequence <400> 128 uguuuugguu aauaaaac 18 <210> 129 <211> 18 <212> DNA <213> Artificial Sequence <400> 129 ccuguuaugu gugugauu 18 <210> 130 <211> 18 <212> DNA <213> Artificial Sequence <400> 130 cugagaguug gcaugaau 18 <210> 131 <211> 18 <212> DNA <213> Artificial Sequence <400> 131 caaccaugca ucuuggaa 18 <210> 132 <211> 18 <212> DNA <213> Artificial Sequence <400> 132 gugcugauuc cuagacuu 18 <210> 133 <211> 18 <212> DNA <213> Artificial Sequence <400> 133 cgcugagcug cugccugg 18 <210> 134 <211> 18 <212> DNA <213> Artificial Sequence <400> 134 ugugcuaugg caaaucug 18 <210> 135 <211> 18 <212> DNA <213> Artificial Sequence <400> 135 uuguuugcuu ugcuaaag 18 <210> 136 <211> 18 <212> DNA <213> Artificial Sequence <400> 136 acgucccggg aggcggca 18 <210> 137 <211> 18 <212> DNA <213> Artificial Sequence <400> 137 ggcggggcac ugugcgug 18 <210> 138 <211> 18 <212> DNA <213> Artificial Sequence <400> 138 cguguggauc ggcggcuc 18 <210> 139 <211> 18 <212> DNA <213> Artificial Sequence <400> 139 uccaggcugu gcuauccc 18 <210> 140 <211> 18 <212> DNA <213> Artificial Sequence <400> 140 ucaggauuua aaaacugg 18 <210> 141 <211> 18 <212> DNA <213> Artificial Sequence <400> 141 ucuagaaucc uaaaggca 18 <210> 142 <211> 18 <212> DNA <213> Artificial Sequence <400> 142 uuguggccuu uuucuccu 18 <210> 143 <211> 18 <212> DNA <213> Artificial Sequence <400> 143 ugguguaucu ugucuuua 18 <210> 144 <211> 18 <212> DNA <213> Artificial Sequence <400> 144 gauaucgccg cgcucguc 18 <210> 145 <211> 18 <212> DNA <213> Artificial Sequence <400> 145 cggcggcggc ggcggcgg 18 <210> 146 <211> 18 <212> DNA <213> Artificial Sequence <400> 146 acaacggcuc cggcaugu 18 <210> 147 <211> 18 <212> DNA <213> Artificial Sequence <400> 147 ggcggcggcg gcggcggc 18 <210> 148 <211> 18 <212> DNA <213> Artificial Sequence <400> 148 agccauacua uuuaugug 18 <210> 149 <211> 18 <212> DNA <213> Artificial Sequence <400> 149 ugaaagcgaa aguaaagc 18 <210> 150 <211> 18 <212> DNA <213> Artificial Sequence <400> 150 gcggcggcgg cggcggcg 18 <210> 151 <211> 18 <212> DNA <213> Artificial Sequence <400> 151 cuggaucuua gcaacguc 18 <210> 152 <211> 18 <212> DNA <213> Artificial Sequence <400> 152 gucuauuuuc ccacccuu 18 <210> 153 <211> 18 <212> DNA <213> Artificial Sequence <400> 153 uugguaucaa gguuacaa 18 <210> 154 <211> 18 <212> DNA <213> Artificial Sequence <400> 154 gcucguggag accaucuu 18 <210> 155 <211> 18 <212> DNA <213> Artificial Sequence <400> 155 ggagcgagca ucccccaa 18 <210> 156 <211> 18 <212> DNA <213> Artificial Sequence <400> 156 cuuuuuucug gcuaccaa 18 <210> 157 <211> 18 <212> DNA <213> Artificial Sequence <400> 157 cuccuccuga gcgcaagu 18 <210> 158 <211> 18 <212> DNA <213> Artificial Sequence <400> 158 cgccucuggc cguaccac 18 <210> 159 <211> 18 <212> DNA <213> Artificial Sequence <400> 159 gcagcagcag cagcagca 18 <210> 160 <211> 18 <212> DNA <213> Artificial Sequence <400> 160 gcgccuauag cacucgaa 18 <210> 161 <211> 18 <212> DNA <213> Artificial Sequence <400> 161 uucacacucg aagauuuc 18 <210> 162 <211> 18 <212> DNA <213> Artificial Sequence <400> 162 agcagcagca gcagcagc 18 <210> 163 <211> 18 <212> DNA <213> Artificial Sequence <400> 163 gggguaaacu ggggucgc 18 <210> 164 <211> 18 <212> DNA <213> Artificial Sequence <400> 164 uuuguuucag aaucucgg 18 <210> 165 <211> 18 <212> DNA <213> Artificial Sequence <400> 165 ggcaaaaaga ucacucac 18 <210> 166 <211> 18 <212> DNA <213> Artificial Sequence <400> 166 cgauggcucu ucuccacu 18 <210> 167 <211> 18 <212> DNA <213> Artificial Sequence <400> 167 ccaguccaag uguggcuc 18 <210> 168 <211> 18 <212> DNA <213> Artificial Sequence <400> 168 cagcagcagc agcagcag 18 <210> 169 <211> 2610 <212> DNA <213> Artificial Sequence <400> 169 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1380 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 2220 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 170 <211> 2610 <212> DNA <213> Artificial Sequence <400> 170 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1800 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 171 <211> 2610 <212> DNA <213> Artificial Sequence <400> 171 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 2220 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 172 <211> 2610 <212> DNA <213> Artificial Sequence <400> 172 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 660 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 173 <211> 2610 <212> DNA <213> Artificial Sequence <400> 173 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 660 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 2220 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 174 <211> 2610 <212> DNA <213> Artificial Sequence <400> 174 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 175 <211> 2610 <212> DNA <213> Artificial Sequence <400> 175 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1380 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1800 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 2220 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 176 <211> 2610 <212> DNA <213> Artificial Sequence <400> 176 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 177 <211> 2610 <212> DNA <213> Artificial Sequence <400> 177 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 178 <211> 2610 <212> DNA <213> Artificial Sequence <400> 178 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 960 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1380 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1800 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 2220 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 179 <211> 2610 <212> DNA <213> Artificial Sequence <400> 179 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 960 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 2220 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 180 <211> 2610 <212> DNA <213> Artificial Sequence <400> 180 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 960 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1380 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 181 <211> 2610 <212> DNA <213> Artificial Sequence <400> 181 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 182 <211> 2610 <212> DNA <213> Artificial Sequence <400> 182 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 183 <211> 2610 <212> DNA <213> Artificial Sequence <400> 183 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 184 <211> 2610 <212> DNA <213> Artificial Sequence <400> 184 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 185 <211> 2610 <212> DNA <213> Artificial Sequence <400> 185 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 960 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1800 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 2220 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 186 <211> 2610 <212> DNA <213> Artificial Sequence <400> 186 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1380 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 187 <211> 2610 <212> DNA <213> Artificial Sequence <400> 187 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 960 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 188 <211> 2610 <212> DNA <213> Artificial Sequence <400> 188 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 660 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 189 <211> 2610 <212> DNA <213> Artificial Sequence <400> 189 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 2220 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 190 <211> 2610 <212> DNA <213> Artificial Sequence <400> 190 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 191 <211> 2610 <212> DNA <213> Artificial Sequence <400> 191 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1380 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 192 <211> 2610 <212> DNA <213> Artificial Sequence <400> 192 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1380 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 2220 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 193 <211> 2610 <212> DNA <213> Artificial Sequence <400> 193 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 194 <211> 2610 <212> DNA <213> Artificial Sequence <400> 194 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 960 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1800 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 195 <211> 2610 <212> DNA <213> Artificial Sequence <400> 195 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 960 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1380 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 2220 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 196 <211> 2610 <212> DNA <213> Artificial Sequence <400> 196 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 2220 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 197 <211> 2610 <212> DNA <213> Artificial Sequence <400> 197 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 198 <211> 2610 <212> DNA <213> Artificial Sequence <400> 198 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 660 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 2220 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 199 <211> 2610 <212> DNA <213> Artificial Sequence <400> 199 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 200 <211> 2610 <212> DNA <213> Artificial Sequence <400> 200 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 660 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 201 <211> 2610 <212> DNA <213> Artificial Sequence <400> 201 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1380 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 202 <211> 2610 <212> DNA <213> Artificial Sequence <400> 202 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 203 <211> 2610 <212> DNA <213> Artificial Sequence <400> 203 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 204 <211> 2610 <212> DNA <213> Artificial Sequence <400> 204 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 205 <211> 2610 <212> DNA <213> Artificial Sequence <400> 205 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 206 <211> 2610 <212> DNA <213> Artificial Sequence <400> 206 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1380 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 207 <211> 2610 <212> DNA <213> Artificial Sequence <400> 207 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1380 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 208 <211> 2610 <212> DNA <213> Artificial Sequence <400> 208 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 209 <211> 2610 <212> DNA <213> Artificial Sequence <400> 209 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1380 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 210 <211> 2610 <212> DNA <213> Artificial Sequence <400> 210 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1380 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 211 <211> 2610 <212> DNA <213> Artificial Sequence <400> 211 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 212 <211> 2610 <212> DNA <213> Artificial Sequence <400> 212 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 213 <211> 2610 <212> DNA <213> Artificial Sequence <400> 213 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1380 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 2220 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 214 <211> 2610 <212> DNA <213> Artificial Sequence <400> 214 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 660 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 215 <211> 2610 <212> DNA <213> Artificial Sequence <400> 215 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 1800 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 216 <211> 2610 <212> DNA <213> Artificial Sequence <400> 216 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggac 960 gaagccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 217 <211> 2610 <212> DNA <213> Artificial Sequence <400> 217 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 218 <211> 2610 <212> DNA <213> Artificial Sequence <400> 218 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 960 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggacgaagc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggac 1380 gaggccgaag agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggacgaagc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 219 <211> 2610 <212> DNA <213> Artificial Sequence <400> 219 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1200 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 220 <211> 2610 <212> DNA <213> Artificial Sequence <400> 220 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 221 <211> 30 <212> DNA <213> Artificial Sequence <400> 221 gacaugcgug aaggugacag cagucgacug 30 <210> 222 <211> 30 <212> DNA <213> Artificial Sequence <400> 222 gacaugccgg gccuccggug uucuggacug 30 <210> 223 <211> 30 <212> DNA <213> Artificial Sequence <400> 223 gacaugccuu aucagacuga uguuggacug 30 <210> 224 <211> 30 <212> DNA <213> Artificial Sequence <400> 224 gacaugcacg uggaugaagu ugguggacug 30 <210> 225 <211> 30 <212> DNA <213> Artificial Sequence <400> 225 gacaugcagc uuaucagacu gaugugacug 30 <210> 226 <211> 30 <212> DNA <213> Artificial Sequence <400> 226 gacaugcgcu uaucagacug auguugacug 30 <210> 227 <211> 30 <212> DNA <213> Artificial Sequence <400> 227 gacaugccau guucgaauuc guuuugacug 30 <210> 228 <211> 30 <212> DNA <213> Artificial Sequence <400> 228 gacaugcugc ugggcaaggu gaacggacug 30 <210> 229 <211> 30 <212> DNA <213> Artificial Sequence <400> 229 gacaugcuag cuuaucagac ugauggacug 30 <210> 230 <211> 30 <212> DNA <213> Artificial Sequence <400> 230 gacaugcuuu uauugugcua uggcagacug 30 <210> 231 <211> 30 <212> DNA <213> Artificial Sequence <400> 231 gacaugcucc ucaccgguga cuggugacug 30 <210> 232 <211> 30 <212> DNA <213> Artificial Sequence <400> 232 gacaugcugu uuugguuaau aaaacgacug 30 <210> 233 <211> 30 <212> DNA <213> Artificial Sequence <400> 233 gacaugcccu guuaugugug ugauugacug 30 <210> 234 <211> 30 <212> DNA <213> Artificial Sequence <400> 234 gacaugccug agaguuggca ugaaugacug 30 <210> 235 <211> 30 <212> DNA <213> Artificial Sequence <400> 235 gacaugccaa ccaugcaucu uggaagacug 30 <210> 236 <211> 30 <212> DNA <213> Artificial Sequence <400> 236 gacaugcgug cugauuccua gacuugacug 30 <210> 237 <211> 30 <212> DNA <213> Artificial Sequence <400> 237 gacaugccgc ugagcugcug ccugggacug 30 <210> 238 <211> 30 <212> DNA <213> Artificial Sequence <400> 238 gacaugcugu gcuauggcaa aucuggacug 30 <210> 239 <211> 30 <212> DNA <213> Artificial Sequence <400> 239 gacaugcuug uuugcuuugc uaaaggacug 30 <210> 240 <211> 30 <212> DNA <213> Artificial Sequence <400> 240 gacaugcacg ucccgggagg cggcagacug 30 <210> 241 <211> 30 <212> DNA <213> Artificial Sequence <400> 241 gacaugcggc ggggcacugu gcguggacug 30 <210> 242 <211> 30 <212> DNA <213> Artificial Sequence <400> 242 gacaugccgu guggaucggc ggcucgacug 30 <210> 243 <211> 30 <212> DNA <213> Artificial Sequence <400> 243 gacaugcucc aggcugugcu aucccgacug 30 <210> 244 <211> 30 <212> DNA <213> Artificial Sequence <400> 244 gacaugcuca ggauuuaaaa acugggacug 30 <210> 245 <211> 30 <212> DNA <213> Artificial Sequence <400> 245 gacaugcucu agaauccuaa aggcagacug 30 <210> 246 <211> 30 <212> DNA <213> Artificial Sequence <400> 246 gacaugcuug uggccuuuuu cuccugacug 30 <210> 247 <211> 30 <212> DNA <213> Artificial Sequence <400> 247 gacaugcugg uguaucuugu cuuuagacug 30 <210> 248 <211> 30 <212> DNA <213> Artificial Sequence <400> 248 gacaugcgau aucgccgcgc ucgucgacug 30 <210> 249 <211> 30 <212> DNA <213> Artificial Sequence <400> 249 gacaugccgg cggcggcggc ggcgggacug 30 <210> 250 <211> 30 <212> DNA <213> Artificial Sequence <400> 250 gacaugcaca acggcuccgg caugugacug 30 <210> 251 <211> 30 <212> DNA <213> Artificial Sequence <400> 251 gacaugcggc ggcggcggcg gcggcgacug 30 <210> 252 <211> 30 <212> DNA <213> Artificial Sequence <400> 252 gacaugcagc cauacuauuu auguggacug 30 <210> 253 <211> 30 <212> DNA <213> Artificial Sequence <400> 253 gacaugcuga aagcgaaagu aaagcgacug 30 <210> 254 <211> 30 <212> DNA <213> Artificial Sequence <400> 254 gacaugcgcg gcggcggcgg cggcggacug 30 <210> 255 <211> 30 <212> DNA <213> Artificial Sequence <400> 255 gacaugccug gaucuuagca acgucgacug 30 <210> 256 <211> 30 <212> DNA <213> Artificial Sequence <400> 256 gacaugcguc uauuuuccca cccuugacug 30 <210> 257 <211> 30 <212> DNA <213> Artificial Sequence <400> 257 gacaugcuug guaucaaggu uacaagacug 30 <210> 258 <211> 30 <212> DNA <213> Artificial Sequence <400> 258 gacaugcgcu cguggagacc aucuugacug 30 <210> 259 <211> 30 <212> DNA <213> Artificial Sequence <400> 259 gacaugcgga gcgagcaucc cccaagacug 30 <210> 260 <211> 30 <212> DNA <213> Artificial Sequence <400> 260 gacaugccuu uuuucuggcu accaagacug 30 <210> 261 <211> 30 <212> DNA <213> Artificial Sequence <400> 261 gacaugccuc cuccugagcg caagugacug 30 <210> 262 <211> 30 <212> DNA <213> Artificial Sequence <400> 262 gacaugccgc cucuggccgu accacgacug 30 <210> 263 <211> 30 <212> DNA <213> Artificial Sequence <400> 263 gacaugcgca gcagcagcag cagcagacug 30 <210> 264 <211> 30 <212> DNA <213> Artificial Sequence <400> 264 gacaugcgcg ccuauagcac ucgaagacug 30 <210> 265 <211> 30 <212> DNA <213> Artificial Sequence <400> 265 gacaugcuuc acacucgaag auuucgacug 30 <210> 266 <211> 30 <212> DNA <213> Artificial Sequence <400> 266 gacaugcagc agcagcagca gcagcgacug 30 <210> 267 <211> 30 <212> DNA <213> Artificial Sequence <400> 267 gacaugcggg guaaacuggg gucgcgacug 30 <210> 268 <211> 30 <212> DNA <213> Artificial Sequence <400> 268 gacaugcuuu guuucagaau cucgggacug 30 <210> 269 <211> 30 <212> DNA <213> Artificial Sequence <400> 269 gacaugcggc aaaaagauca cucacgacug 30 <210> 270 <211> 30 <212> DNA <213> Artificial Sequence <400> 270 gacaugccga uggcucuucu ccacugacug 30 <210> 271 <211> 30 <212> DNA <213> Artificial Sequence <400> 271 gacaugccca guccaagugu ggcucgacug 30 <210> 272 <211> 30 <212> DNA <213> Artificial Sequence <400> 272 gacaugccag cagcagcagc agcaggacug 30 <210> 273 <211> 18 <212> DNA <213> Artificial Sequence <400> 273 gaaugaacuc uuccggga 18 <210> 274 <211> 18 <212> DNA <213> Artificial Sequence <400> 274 gaaugaacuc uuccggga 18 <210> 275 <211> 18 <212> DNA <213> Artificial Sequence <400> 275 ucuagaaucc uaaaggca 18 <210> 276 <211> 18 <212> DNA <213> Artificial Sequence <400> 276 ucuagaaucc uaaaggca 18 <210> 277 <211> 18 <212> DNA <213> Artificial Sequence <400> 277 cugagucaua accagccu 18 <210> 278 <211> 18 <212> DNA <213> Artificial Sequence <400> 278 cugagucaua accagccu 18 <210> 279 <211> 18 <212> DNA <213> Artificial Sequence <400> 279 gucagagggu ucuggauu 18 <210> 280 <211> 18 <212> DNA <213> Artificial Sequence <400> 280 gucagagggu ucuggauu 18 <210> 281 <211> 18 <212> DNA <213> Artificial Sequence <400> 281 gugcugauuc cuagacuu 18 <210> 282 <211> 18 <212> DNA <213> Artificial Sequence <400> 282 gugcugauuc cuagacuu 18 <210> 283 <211> 18 <212> DNA <213> Artificial Sequence <400> 283 gacucaggaa ucggcucu 18 <210> 284 <211> 18 <212> DNA <213> Artificial Sequence <400> 284 gacucaggaa ucggcucu 18 <210> 285 <211> 18 <212> DNA <213> Artificial Sequence <400> 285 caacaucaaa gacaccau 18 <210> 286 <211> 18 <212> DNA <213> Artificial Sequence <400> 286 caacaucaaa gacaccau 18 <210> 287 <211> 18 <212> DNA <213> Artificial Sequence <400> 287 gagaggaagc cugagagu 18 <210> 288 <211> 18 <212> DNA <213> Artificial Sequence <400> 288 gagaggaagc cugagagu 18 <210> 289 <211> 18 <212> DNA <213> Artificial Sequence <400> 289 cugagaguug gcaugaau 18 <210> 290 <211> 18 <212> DNA <213> Artificial Sequence <400> 290 cugagaguug gcaugaau 18 <210> 291 <211> 18 <212> DNA <213> Artificial Sequence <400> 291 ccuguuaugu gugugauu 18 <210> 292 <211> 18 <212> DNA <213> Artificial Sequence <400> 292 ccuguuaugu gugugauu 18 <210> 293 <211> 18 <212> DNA <213> Artificial Sequence <400> 293 caaccaugca ucuuggaa 18 <210> 294 <211> 18 <212> DNA <213> Artificial Sequence <400> 294 caaccaugca ucuuggaa 18 <210> 295 <211> 18 <212> DNA <213> Artificial Sequence <400> 295 agccauacua uuuaugug 18 <210> 296 <211> 18 <212> DNA <213> Artificial Sequence <400> 296 agccauacua uuuaugug 18 <210> 297 <211> 18 <212> DNA <213> Artificial Sequence <400> 297 gcgccuauag cacucgaa 18 <210> 298 <211> 18 <212> DNA <213> Artificial Sequence <400> 298 gcgccuauag cacucgaa 18 <210> 299 <211> 764 <212> PRT <213> Artificial Sequence <400> 299 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 300 <211> 659 <212> PRT <213> Artificial Sequence <400> 300 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 450 455 460 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 301 <211> 764 <212> PRT <213> Artificial Sequence <400> 301 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 302 <211> 659 <212> PRT <213> Artificial Sequence <400> 302 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 303 <211> 764 <212> PRT <213> Artificial Sequence <400> 303 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 304 <211> 659 <212> PRT <213> Artificial Sequence <400> 304 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 305 <211> 764 <212> PRT <213> Artificial Sequence <400> 305 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 306 <211> 659 <212> PRT <213> Artificial Sequence <400> 306 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 307 <211> 764 <212> PRT <213> Artificial Sequence <400> 307 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 450 455 460 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 308 <211> 659 <212> PRT <213> Artificial Sequence <400> 308 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 309 <211> 764 <212> PRT <213> Artificial Sequence <400> 309 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 310 <211> 659 <212> PRT <213> Artificial Sequence <400> 310 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 311 <211> 764 <212> PRT <213> Artificial Sequence <400> 311 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 312 <211> 659 <212> PRT <213> Artificial Sequence <400> 312 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 313 <211> 764 <212> PRT <213> Artificial Sequence <400> 313 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 450 455 460 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 314 <211> 659 <212> PRT <213> Artificial Sequence <400> 314 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 315 <211> 764 <212> PRT <213> Artificial Sequence <400> 315 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 316 <211> 659 <212> PRT <213> Artificial Sequence <400> 316 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 317 <211> 764 <212> PRT <213> Artificial Sequence <400> 317 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 318 <211> 659 <212> PRT <213> Artificial Sequence <400> 318 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 319 <211> 764 <212> PRT <213> Artificial Sequence <400> 319 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 320 <211> 659 <212> PRT <213> Artificial Sequence <400> 320 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 321 <211> 764 <212> PRT <213> Artificial Sequence <400> 321 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 322 <211> 659 <212> PRT <213> Artificial Sequence <400> 322 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 323 <211> 764 <212> PRT <213> Artificial Sequence <400> 323 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 450 455 460 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 725 730 735 Gly Arg Ala Arg Asp Pro Pro Val Leu Ser Ser Gly Ser Gly Gly Ser 740 745 750 Gly Gly Gly Gly His His His His His His Gly Arg 755 760 <210> 324 <211> 659 <212> PRT <213> Artificial Sequence <400> 324 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn Thr Leu 610 615 620 Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val Leu 625 630 635 640 Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His His His 645 650 655 His Gly Arg <210> 325 <211> 18 <212> DNA <213> Artificial Sequence <400> 325 ugccccacag cuuuaagg 18 <210> 326 <211> 18 <212> DNA <213> Artificial Sequence <400> 326 gcuaaccucu gcgcuucu 18 <210> 327 <211> 18 <212> DNA <213> Artificial Sequence <400> 327 gcuucuuccc uucccucc 18 <210> 328 <211> 18 <212> DNA <213> Artificial Sequence <400> 328 cccuccuccc uggcucag 18 <210> 329 <211> 18 <212> DNA <213> Artificial Sequence <400> 329 gcucaggauc caggcgau 18 <210> 330 <211> 18 <212> DNA <213> Artificial Sequence <400> 330 ggcgauaucc ggaagaau 18 <210> 331 <211> 657 <212> PRT <213> Artificial Sequence <400> 331 Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 20 25 30 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 50 55 60 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 85 90 95 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr 100 105 110 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 115 120 125 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser 130 135 140 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 145 150 155 160 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 165 170 175 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 195 200 205 Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 225 230 235 240 Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 260 265 270 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr 275 280 285 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 290 295 300 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val 305 310 315 320 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 325 330 335 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 340 345 350 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 370 375 380 Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 405 410 415 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 435 440 445 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 465 470 475 480 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val 485 490 495 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 500 505 510 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 515 520 525 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 545 550 555 560 Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 580 585 590 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 610 615 620 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 332 <211> 657 <212> PRT <213> Artificial Sequence <400> 332 Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 20 25 30 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 50 55 60 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 85 90 95 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr 100 105 110 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 115 120 125 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn 130 135 140 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 145 150 155 160 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 165 170 175 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 195 200 205 Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 225 230 235 240 Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 260 265 270 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 290 295 300 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 325 330 335 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 340 345 350 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 370 375 380 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 405 410 415 Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 435 440 445 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 465 470 475 480 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val 485 490 495 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 500 505 510 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 515 520 525 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 545 550 555 560 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 580 585 590 Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 610 615 620 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 333 <211> 657 <212> PRT <213> Artificial Sequence <400> 333 Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 20 25 30 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 50 55 60 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 85 90 95 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr 100 105 110 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 115 120 125 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 130 135 140 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 145 150 155 160 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 165 170 175 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 195 200 205 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 225 230 235 240 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 260 265 270 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 290 295 300 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 325 330 335 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 340 345 350 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 370 375 380 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 405 410 415 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 435 440 445 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 465 470 475 480 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val 485 490 495 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 500 505 510 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 515 520 525 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 545 550 555 560 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 580 585 590 Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 610 615 620 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 334 <211> 657 <212> PRT <213> Artificial Sequence <400> 334 Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 20 25 30 Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 50 55 60 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 85 90 95 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr 100 105 110 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 115 120 125 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 130 135 140 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 145 150 155 160 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 165 170 175 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 195 200 205 Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 225 230 235 240 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 260 265 270 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 290 295 300 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 325 330 335 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 340 345 350 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 370 375 380 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 405 410 415 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 435 440 445 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 465 470 475 480 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val 485 490 495 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 500 505 510 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 515 520 525 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 545 550 555 560 Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 580 585 590 Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 610 615 620 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 335 <211> 657 <212> PRT <213> Artificial Sequence <400> 335 Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 20 25 30 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 50 55 60 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 85 90 95 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr 100 105 110 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 115 120 125 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser 130 135 140 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 145 150 155 160 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 165 170 175 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 195 200 205 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 225 230 235 240 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 260 265 270 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 290 295 300 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 325 330 335 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 340 345 350 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 370 375 380 Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 405 410 415 Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 435 440 445 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 465 470 475 480 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val 485 490 495 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 500 505 510 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 515 520 525 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 545 550 555 560 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 580 585 590 Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 610 615 620 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 336 <211> 657 <212> PRT <213> Artificial Sequence <400> 336 Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 20 25 30 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 50 55 60 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 85 90 95 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr 100 105 110 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 115 120 125 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 130 135 140 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 145 150 155 160 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 165 170 175 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 195 200 205 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 225 230 235 240 Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 260 265 270 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 290 295 300 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 325 330 335 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 340 345 350 Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 370 375 380 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 405 410 415 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 435 440 445 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 465 470 475 480 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val 485 490 495 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 500 505 510 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 515 520 525 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 545 550 555 560 Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 580 585 590 Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 610 615 620 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 337 <211> 657 <212> PRT <213> Artificial Sequence <400> 337 Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 20 25 30 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 50 55 60 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 85 90 95 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 100 105 110 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 115 120 125 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 130 135 140 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 145 150 155 160 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 165 170 175 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 195 200 205 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 225 230 235 240 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 260 265 270 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 275 280 285 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 290 295 300 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 305 310 315 320 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 325 330 335 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 340 345 350 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 355 360 365 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 370 375 380 Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 405 410 415 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 435 440 445 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 465 470 475 480 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 485 490 495 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 500 505 510 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 515 520 525 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 545 550 555 560 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 580 585 590 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 610 615 620 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 338 <211> 657 <212> PRT <213> Artificial Sequence <400> 338 Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 20 25 30 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 50 55 60 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 85 90 95 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 100 105 110 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 115 120 125 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 130 135 140 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 145 150 155 160 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 165 170 175 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 195 200 205 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 225 230 235 240 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 260 265 270 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 290 295 300 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 325 330 335 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 340 345 350 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 370 375 380 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 405 410 415 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 435 440 445 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 465 470 475 480 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 485 490 495 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 500 505 510 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 515 520 525 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 545 550 555 560 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 580 585 590 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 610 615 620 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 339 <211> 657 <212> PRT <213> Artificial Sequence <400> 339 Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 20 25 30 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 50 55 60 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 85 90 95 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 100 105 110 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 115 120 125 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 130 135 140 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 145 150 155 160 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 165 170 175 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 195 200 205 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 225 230 235 240 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 260 265 270 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 290 295 300 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 325 330 335 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 340 345 350 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 370 375 380 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 405 410 415 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 435 440 445 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 465 470 475 480 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 485 490 495 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 500 505 510 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 515 520 525 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 545 550 555 560 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 580 585 590 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 610 615 620 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 340 <211> 657 <212> PRT <213> Artificial Sequence <400> 340 Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 20 25 30 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 50 55 60 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 85 90 95 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 100 105 110 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 115 120 125 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 130 135 140 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 145 150 155 160 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 165 170 175 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 195 200 205 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 225 230 235 240 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 260 265 270 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 290 295 300 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 325 330 335 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 340 345 350 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 370 375 380 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 405 410 415 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 435 440 445 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 465 470 475 480 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 485 490 495 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 500 505 510 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 515 520 525 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 530 535 540 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 545 550 555 560 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 580 585 590 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 610 615 620 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 341 <211> 657 <212> PRT <213> Artificial Sequence <400> 341 Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 20 25 30 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 50 55 60 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 85 90 95 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 100 105 110 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 115 120 125 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 130 135 140 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 145 150 155 160 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 165 170 175 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 195 200 205 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 225 230 235 240 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 260 265 270 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 290 295 300 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 325 330 335 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 340 345 350 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 355 360 365 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 370 375 380 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 405 410 415 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 435 440 445 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 465 470 475 480 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 485 490 495 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 500 505 510 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 515 520 525 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 545 550 555 560 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 580 585 590 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 610 615 620 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 342 <211> 657 <212> PRT <213> Artificial Sequence <400> 342 Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 1 5 10 15 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 20 25 30 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 35 40 45 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 50 55 60 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 65 70 75 80 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 85 90 95 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 100 105 110 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 115 120 125 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 130 135 140 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 145 150 155 160 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 165 170 175 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 180 185 190 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 195 200 205 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 210 215 220 Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 225 230 235 240 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 245 250 255 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 260 265 270 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 275 280 285 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 290 295 300 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 305 310 315 320 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 325 330 335 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 340 345 350 Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 355 360 365 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 370 375 380 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 385 390 395 400 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 405 410 415 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 420 425 430 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 435 440 445 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 450 455 460 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 465 470 475 480 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 485 490 495 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 500 505 510 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 515 520 525 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 530 535 540 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 545 550 555 560 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 565 570 575 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 580 585 590 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 595 600 605 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 610 615 620 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr 625 630 635 640 Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro Val 645 650 655 Leu <210> 343 <211> 738 <212> PRT <213> Artificial Sequence <400> 343 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 65 70 75 80 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 100 105 110 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 130 135 140 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 145 150 155 160 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 180 185 190 Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 210 215 220 Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 245 250 255 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 275 280 285 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 305 310 315 320 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser 325 330 335 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 340 345 350 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 355 360 365 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 385 390 395 400 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 420 425 430 Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 450 455 460 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 465 470 475 480 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 485 490 495 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val 500 505 510 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 515 520 525 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 530 535 540 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 565 570 575 Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 595 600 605 Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 625 630 635 640 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 660 665 670 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 344 <211> 738 <212> PRT <213> Artificial Sequence <400> 344 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 65 70 75 80 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 100 105 110 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 130 135 140 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 145 150 155 160 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 180 185 190 Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 210 215 220 Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 245 250 255 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 275 280 285 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 305 310 315 320 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 340 345 350 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 355 360 365 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 385 390 395 400 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 420 425 430 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 450 455 460 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr 465 470 475 480 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 485 490 495 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val 500 505 510 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 515 520 525 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 530 535 540 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 565 570 575 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 595 600 605 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 625 630 635 640 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 660 665 670 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 345 <211> 738 <212> PRT <213> Artificial Sequence <400> 345 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 65 70 75 80 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 100 105 110 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 130 135 140 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 145 150 155 160 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 180 185 190 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 210 215 220 Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 245 250 255 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 275 280 285 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 305 310 315 320 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 340 345 350 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 355 360 365 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 385 390 395 400 Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 420 425 430 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 450 455 460 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 465 470 475 480 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 485 490 495 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val 500 505 510 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 515 520 525 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 530 535 540 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 565 570 575 Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 595 600 605 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 625 630 635 640 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 660 665 670 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 346 <211> 738 <212> PRT <213> Artificial Sequence <400> 346 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 65 70 75 80 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 100 105 110 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 130 135 140 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 145 150 155 160 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 180 185 190 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 210 215 220 Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 245 250 255 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 275 280 285 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 305 310 315 320 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 340 345 350 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 355 360 365 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 385 390 395 400 Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 420 425 430 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 450 455 460 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 465 470 475 480 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 485 490 495 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val 500 505 510 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 515 520 525 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 530 535 540 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 565 570 575 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 595 600 605 Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 625 630 635 640 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 660 665 670 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 347 <211> 738 <212> PRT <213> Artificial Sequence <400> 347 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 65 70 75 80 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 100 105 110 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 130 135 140 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 145 150 155 160 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 180 185 190 Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 210 215 220 Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 245 250 255 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 275 280 285 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr 290 295 300 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 305 310 315 320 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 340 345 350 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 355 360 365 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 385 390 395 400 Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 420 425 430 Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 450 455 460 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr 465 470 475 480 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 485 490 495 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val 500 505 510 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 515 520 525 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 530 535 540 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 565 570 575 Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 595 600 605 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 625 630 635 640 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 660 665 670 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 348 <211> 738 <212> PRT <213> Artificial Sequence <400> 348 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 65 70 75 80 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 100 105 110 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 130 135 140 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 145 150 155 160 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 180 185 190 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 210 215 220 Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 245 250 255 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 275 280 285 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 305 310 315 320 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 340 345 350 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 355 360 365 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 385 390 395 400 Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 420 425 430 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 450 455 460 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 465 470 475 480 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 485 490 495 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val 500 505 510 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 515 520 525 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 530 535 540 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 565 570 575 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 595 600 605 Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 625 630 635 640 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 660 665 670 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 349 <211> 738 <212> PRT <213> Artificial Sequence <400> 349 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 65 70 75 80 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 100 105 110 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 130 135 140 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 145 150 155 160 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 165 170 175 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 180 185 190 Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 210 215 220 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 245 250 255 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 275 280 285 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 305 310 315 320 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 325 330 335 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 340 345 350 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 355 360 365 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 385 390 395 400 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 420 425 430 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 450 455 460 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 465 470 475 480 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 485 490 495 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 500 505 510 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 515 520 525 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 530 535 540 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 565 570 575 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 595 600 605 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 625 630 635 640 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 660 665 670 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 350 <211> 738 <212> PRT <213> Artificial Sequence <400> 350 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 65 70 75 80 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 100 105 110 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 130 135 140 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 145 150 155 160 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 180 185 190 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 210 215 220 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 245 250 255 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 275 280 285 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 305 310 315 320 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 340 345 350 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 355 360 365 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 385 390 395 400 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 420 425 430 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 450 455 460 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 465 470 475 480 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 485 490 495 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 500 505 510 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 515 520 525 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 530 535 540 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 565 570 575 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 595 600 605 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 625 630 635 640 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 660 665 670 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 351 <211> 738 <212> PRT <213> Artificial Sequence <400> 351 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 65 70 75 80 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 100 105 110 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 130 135 140 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 145 150 155 160 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 180 185 190 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 210 215 220 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 245 250 255 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 275 280 285 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 305 310 315 320 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 340 345 350 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 355 360 365 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 385 390 395 400 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 420 425 430 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 450 455 460 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 465 470 475 480 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 485 490 495 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 500 505 510 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 515 520 525 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 530 535 540 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 545 550 555 560 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 565 570 575 Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 595 600 605 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 625 630 635 640 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 660 665 670 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 352 <211> 738 <212> PRT <213> Artificial Sequence <400> 352 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 65 70 75 80 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 100 105 110 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 130 135 140 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 145 150 155 160 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 180 185 190 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 210 215 220 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 245 250 255 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 275 280 285 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 305 310 315 320 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 340 345 350 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 355 360 365 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 385 390 395 400 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 420 425 430 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 450 455 460 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 465 470 475 480 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 485 490 495 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 500 505 510 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 515 520 525 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 530 535 540 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 565 570 575 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 595 600 605 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 625 630 635 640 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 660 665 670 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 353 <211> 738 <212> PRT <213> Artificial Sequence <400> 353 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 65 70 75 80 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 100 105 110 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 130 135 140 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 145 150 155 160 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 165 170 175 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 180 185 190 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 210 215 220 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 245 250 255 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 275 280 285 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 290 295 300 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu 305 310 315 320 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 340 345 350 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 355 360 365 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 385 390 395 400 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 420 425 430 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 450 455 460 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 465 470 475 480 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 485 490 495 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 500 505 510 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 515 520 525 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 530 535 540 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 545 550 555 560 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 565 570 575 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 595 600 605 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 625 630 635 640 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 660 665 670 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 354 <211> 738 <212> PRT <213> Artificial Sequence <400> 354 Met Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys 20 25 30 Lys Lys Arg Lys Val Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 35 40 45 Ser Arg Leu His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile 50 55 60 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 65 70 75 80 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 85 90 95 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 100 105 110 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 115 120 125 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 130 135 140 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 145 150 155 160 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 165 170 175 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 180 185 190 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 195 200 205 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 210 215 220 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 225 230 235 240 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 245 250 255 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 260 265 270 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 275 280 285 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 290 295 300 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 305 310 315 320 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 325 330 335 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 340 345 350 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 355 360 365 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 370 375 380 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 385 390 395 400 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 405 410 415 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 420 425 430 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 435 440 445 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 450 455 460 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 465 470 475 480 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 485 490 495 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 500 505 510 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 515 520 525 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 530 535 540 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 545 550 555 560 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 565 570 575 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 580 585 590 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 595 600 605 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 610 615 620 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 625 630 635 640 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 645 650 655 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 660 665 670 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu 675 680 685 Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg 690 695 700 Asp Pro Pro Val Leu Ser Ser Gly Asp Tyr Lys Asp His Asp Gly Asp 705 710 715 720 Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala 725 730 735 Gly Arg <210> 355 <211> 21 <212> DNA <213> Artificial Sequence <400> 355 caaagtggag gacccagtac c 21 <210> 356 <211> 21 <212> DNA <213> Artificial Sequence <400> 356 gcgcatgaac tccttgatga c 21 <210> 357 <211> 1029 <212> DNA <213> Artificial Sequence <400> 357 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccatg cttctaactt tactcagttc 600 gttctcgtcg acaatggcgg aactggcgac gtgactgtcg ccccaagcaa cttcgctaac 660 ggggtcgctg aatggatcag ctctaactcg cgttcacagg cttacaaagt aacctgtagc 720 gttcgtcaga gctctgcgca gaatcgcaaa tacaccatca aagtcgaggt gcctaaagtg 780 gcaacccaga ctgttggtgg tgtagagctt cctgtagccg catggcgttc gtacctaaat 840 atggaactaa ccattccaat tttcgccacg aattccgact gcgagcttat tgttaaggca 900 atgcaaggtc tcctaaaaga tggaaacccg attccctcag caatcgcagc aaactccggc 960 atctacctca gtagcggctc cggcggcagc gggggaggcg ggcatcatca ccatcaccac 1020 ggacgctag 1029 <210> 358 <211> 105 <212> DNA <213> Artificial Sequence <400> 358 gtcacataca ccacactgat cgacggactg tgtaaagccg gcgacgtgga cgaagccctc 60 gagctgttca aagagatgcg gagcaagggc gtgaagccca acgtg 105 <210> 359 <211> 105 <212> DNA <213> Artificial Sequence <400> 359 gtcacataca acaccctgat cgacggcctg tgcaaggccg gcagactgga tgaggccgag 60 gagctgctgg aggagatgga ggagaagggc atcaagcccg acgtg 105 <210> 360 <211> 105 <212> DNA <213> Artificial Sequence <400> 360 gtcacataca ccaccctgat cgacggcctg tgcaaggccg gcaaggtgga tgaggccctg 60 gagctgttcg acgagatgaa ggagaggggc atcaagcccg acgtg 105 <210> 361 <211> 105 <212> DNA <213> Artificial Sequence <400> 361 gtcacataca acaccctgat cgacggcctg tgcaagagcg gcaagatcga ggaggccctg 60 aagctgttca aggagatgga ggagaagggc atcaccccca gcgtg 105 <210> 362 <211> 105 <212> DNA <213> Artificial Sequence <400> 362 gtcacataca ccaccctgat cgacggcctg tgcaaggccg gcaaagtgga cgaggccctg 60 gagctgttcg acgagatgaa ggagaggggc atcaagcccg acgtg 105 <210> 363 <211> 105 <212> DNA <213> Artificial Sequence <400> 363 gtgacataca ccacactgat cgacggactg tgtaaagccg gcgacgtgga cgaagccctc 60 gagctgttca aagagatgcg gagcaagggc gtgaagccca acgtg 105 <210> 364 <211> 105 <212> DNA <213> Artificial Sequence <400> 364 gtgacataca acaccctgat cgacggcctg tgcaaggccg gcagactgga tgaggccgag 60 gagctgctgg aggagatgga ggagaagggc atcaagcccg acgtg 105 <210> 365 <211> 105 <212> DNA <213> Artificial Sequence <400> 365 gtgacataca ccaccctgat cgacggcctg tgcaaggccg gcaaggtgga tgaggccctg 60 gagctgttcg acgagatgaa ggagaggggc atcaagcccg acgtg 105 <210> 366 <211> 105 <212> DNA <213> Artificial Sequence <400> 366 gtgacataca acaccctgat cgacggcctg tgcaagagcg gcaagatcga ggaggccctg 60 aagctgttca aggagatgga ggagaagggc atcaccccca gcgtg 105 <210> 367 <211> 105 <212> DNA <213> Artificial Sequence <400> 367 gtgacataca ccaccctgat cgacggcctg tgcaaggccg gcaaagtgga cgaggccctg 60 gagctgttcg acgagatgaa ggagaggggc atcaagcccg acgtg 105 <210> 368 <211> 105 <212> DNA <213> Artificial Sequence <400> 368 gttacataca ccacactgat cgacggactg tgtaaagccg gcgacgtgga cgaagccctc 60 gagctgttca aagagatgcg gagcaagggc gtgaagccca acgtg 105 <210> 369 <211> 105 <212> DNA <213> Artificial Sequence <400> 369 gttacataca acaccctgat cgacggcctg tgcaaggccg gcagactgga tgaggccgag 60 gagctgctgg aggagatgga ggagaagggc atcaagcccg acgtg 105 <210> 370 <211> 105 <212> DNA <213> Artificial Sequence <400> 370 gttacataca ccaccctgat cgacggcctg tgcaaggccg gcaaggtgga tgaggccctg 60 gagctgttcg acgagatgaa ggagaggggc atcaagcccg acgtg 105 <210> 371 <211> 105 <212> DNA <213> Artificial Sequence <400> 371 gttacataca acaccctgat cgacggcctg tgcaagagcg gcaagatcga ggaggccctg 60 aagctgttca aggagatgga ggagaagggc atcaccccca gcgtg 105 <210> 372 <211> 105 <212> DNA <213> Artificial Sequence <400> 372 gttacataca ccaccctgat cgacggcctg tgcaaggccg gcaaagtgga cgaggccctg 60 gagctgttcg acgagatgaa ggagaggggc atcaagcccg acgtg 105 <210> 373 <211> 105 <212> DNA <213> Artificial Sequence <400> 373 gtcacataca ccacgctgat cgatggtctg tgtaaggccg gcaaattaga tgaggccctg 60 aagttattcg aagagatggt tgaaaaaggc atcaagccga acgtg 105 <210> 374 <211> 105 <212> DNA <213> Artificial Sequence <400> 374 gtcacataca acaccctgat tgatggctta tgcaaagcgg gtaagctgga tgaagcgtta 60 aaactgtttg aggaaatggt ggagaagggt attaaaccga gcgtg 105 <210> 375 <211> 105 <212> DNA <213> Artificial Sequence <400> 375 gtcacataca ccacgctgat cgatggtctg tgtaaggccg gtaaattaga tgaagcgctg 60 aagttattcg aagagatggt tgaaaaaggt atcaagccgg atgtg 105 <210> 376 <211> 105 <212> DNA <213> Artificial Sequence <400> 376 gtcacataca atacgctgat tgatggctta tgtaaagcgg gtaagctgga tgaggcctta 60 aaactgtttg aggaaatggt ggagaagggc attaaaccgg atgtg 105 <210> 377 <211> 105 <212> DNA <213> Artificial Sequence <400> 377 gtcacataca ccacgctgat cgatggtctg tgtaaggccg gtaaattaga tgaagcgctg 60 aagttattcg aagagatggt tgaaaaaggt atcaagccgg acgtg 105 <210> 378 <211> 105 <212> DNA <213> Artificial Sequence <400> 378 gtcacataca atacgctgat tgatggctta tgtaaagcgg gtaagctgga tgaggcctta 60 aaactgtttg aggaaatggt ggagaagggc attaaaccgg acgtg 105 <210> 379 <211> 105 <212> DNA <213> Artificial Sequence <400> 379 gtgacataca ccacgctgat cgatggtctg tgtaaggccg gcaaattaga tgaggccctg 60 aagttattcg aagagatggt tgaaaaaggc atcaagccga acgtg 105 <210> 380 <211> 105 <212> DNA <213> Artificial Sequence <400> 380 gtgacataca acaccctgat tgatggctta tgcaaagcgg gtaagctgga tgaagcgtta 60 aaactgtttg aggaaatggt ggagaagggt attaaaccga gcgtg 105 <210> 381 <211> 105 <212> DNA <213> Artificial Sequence <400> 381 gtgacataca ccacgctgat cgatggtctg tgtaaggccg gtaaattaga tgaagcgctg 60 aagttattcg aagagatggt tgaaaaaggt atcaagccgg atgtg 105 <210> 382 <211> 105 <212> DNA <213> Artificial Sequence <400> 382 gtgacataca atacgctgat tgatggctta tgtaaagcgg gtaagctgga tgaggcctta 60 aaactgtttg aggaaatggt ggagaagggc attaaaccgg atgtg 105 <210> 383 <211> 105 <212> DNA <213> Artificial Sequence <400> 383 gtgacataca ccacgctgat cgatggtctg tgtaaggccg gtaaattaga tgaagcgctg 60 aagttattcg aagagatggt tgaaaaaggt atcaagccgg acgtg 105 <210> 384 <211> 105 <212> DNA <213> Artificial Sequence <400> 384 gtgacataca atacgctgat tgatggctta tgtaaagcgg gtaagctgga tgaggcctta 60 aaactgtttg aggaaatggt ggagaagggc attaaaccgg acgtg 105 <210> 385 <211> 105 <212> DNA <213> Artificial Sequence <400> 385 gttacataca ccacgctgat cgatggtctg tgtaaggccg gcaaattaga tgaggccctg 60 aagttattcg aagagatggt tgaaaaaggc atcaagccga acgtg 105 <210> 386 <211> 105 <212> DNA <213> Artificial Sequence <400> 386 gttacataca acaccctgat tgatggctta tgcaaagcgg gtaagctgga tgaagcgtta 60 aaactgtttg aggaaatggt ggagaagggt attaaaccga gcgtg 105 <210> 387 <211> 105 <212> DNA <213> Artificial Sequence <400> 387 gttacataca ccacgctgat cgatggtctg tgtaaggccg gtaaattaga tgaagcgctg 60 aagttattcg aagagatggt tgaaaaaggt atcaagccgg atgtg 105 <210> 388 <211> 105 <212> DNA <213> Artificial Sequence <400> 388 gttacataca atacgctgat tgatggctta tgtaaagcgg gtaagctgga tgaggcctta 60 aaactgtttg aggaaatggt ggagaagggc attaaaccgg atgtg 105 <210> 389 <211> 105 <212> DNA <213> Artificial Sequence <400> 389 gttacataca ccacgctgat cgatggtctg tgtaaggccg gtaaattaga tgaagcgctg 60 aagttattcg aagagatggt tgaaaaaggt atcaagccgg acgtg 105 <210> 390 <211> 105 <212> DNA <213> Artificial Sequence <400> 390 gttacataca atacgctgat tgatggctta tgtaaagcgg gtaagctgga tgaggcctta 60 aaactgtttg aggaaatggt ggagaagggc attaaaccgg acgtg 105 <210> 391 <211> 869 <212> PRT <213> Artificial Sequence <400> 391 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 210 215 220 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 245 250 255 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 275 280 285 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 305 310 315 320 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 385 390 395 400 Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 420 425 430 Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 450 455 460 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 485 490 495 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 530 535 540 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 595 600 605 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 625 630 635 640 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 660 665 670 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 690 695 700 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 770 775 780 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 805 810 815 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 392 <211> 869 <212> PRT <213> Artificial Sequence <400> 392 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 210 215 220 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 245 250 255 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 275 280 285 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 305 310 315 320 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 420 425 430 Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 450 455 460 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 485 490 495 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 530 535 540 Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 565 570 575 Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 595 600 605 Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 625 630 635 640 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 660 665 670 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 690 695 700 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 740 745 750 Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 770 775 780 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 805 810 815 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 393 <211> 869 <212> PRT <213> Artificial Sequence <400> 393 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 210 215 220 Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 245 250 255 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 275 280 285 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 305 310 315 320 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 420 425 430 Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 450 455 460 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 485 490 495 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 565 570 575 Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 595 600 605 Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 625 630 635 640 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 660 665 670 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 690 695 700 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 740 745 750 Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 770 775 780 Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 805 810 815 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 394 <211> 869 <212> PRT <213> Artificial Sequence <400> 394 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 210 215 220 Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 245 250 255 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 275 280 285 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 305 310 315 320 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 355 360 365 Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 420 425 430 Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 450 455 460 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 485 490 495 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 530 535 540 Lys Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 565 570 575 Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 595 600 605 Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 625 630 635 640 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 660 665 670 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 690 695 700 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 770 775 780 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 805 810 815 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 395 <211> 869 <212> PRT <213> Artificial Sequence <400> 395 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 210 215 220 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 245 250 255 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu 275 280 285 Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp 305 310 315 320 Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly 355 360 365 Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val 385 390 395 400 Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu 420 425 430 Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys 450 455 460 Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu 485 490 495 Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu 595 600 605 Met Val Glu Lys Gly Ile Lys Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu 625 630 635 640 Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala 660 665 670 Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys Pro Ser Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Leu 690 695 700 Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met Val Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe Glu Glu Met 770 775 780 Val Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Leu Asp Glu Ala Leu Lys Leu Phe 805 810 815 Glu Glu Met Val Glu Lys Gly Ile Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 396 <211> 869 <212> PRT <213> Artificial Sequence <400> 396 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 450 455 460 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 397 <211> 869 <212> PRT <213> Artificial Sequence <400> 397 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 398 <211> 869 <212> PRT <213> Artificial Sequence <400> 398 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 725 730 735 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 740 745 750 Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 770 775 780 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 399 <211> 869 <212> PRT <213> Artificial Sequence <400> 399 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 400 <211> 869 <212> PRT <213> Artificial Sequence <400> 400 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 401 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> v3.1_A <400> 401 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 1 5 10 15 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 20 25 30 Pro Asn Val 35 <210> 402 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> 1st_A <400> 402 Val Thr Tyr Thr Thr Asn Ile Asp Gln Leu Cys Lys Ala Gly Lys Val 1 5 10 15 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 20 25 30 Pro Asn Val 35 <210> 403 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> 1st_C <400> 403 Val Thr Tyr Asn Thr Asn Ile Asp Gln Leu Cys Lys Ser Gly Lys Ile 1 5 10 15 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 20 25 30 Pro Ser Val 35 <210> 404 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> 1st_G <400> 404 Val Thr Tyr Thr Thr Asn Ile Asp Gln Leu Cys Lys Ala Gly Lys Val 1 5 10 15 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 20 25 30 Pro Asp Val 35 <210> 405 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> 1st_U <400> 405 Val Thr Tyr Asn Thr Asn Ile Asp Gln Leu Cys Lys Ala Gly Arg Leu 1 5 10 15 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 20 25 30 Pro Asp Val 35 <210> 406 <211> 105 <212> DNA <213> Artificial Sequence <220> <223> v3.1_A <400> 406 gtgacctaca ccacactgat cgacggactg tgcaaggccg gcaaagtgga tgaggctctg 60 gagctgttta aggaaatgag aagcaagggc gtcaagccca acgtg 105 <210> 407 <211> 105 <212> DNA <213> Artificial Sequence <220> <223> v3.2_A <400> 407 gtcacataca ccaccaacat cgaccagctg tgcaaagccg gcaaggtgga tgaagctctg 60 gagctgttca aggagatgag aagcaagggc gtgaagccca acgtg 105 <210> 408 <211> 105 <212> DNA <213> Artificial Sequence <220> <223> v3.2_C <400> 408 gtcacataca acaccaacat cgaccagctg tgcaaaagcg gcaagatcga ggaggctctg 60 aaactgttca aggagatgga ggagaagggc atcaccccca gcgtg 105 <210> 409 <211> 105 <212> DNA <213> Artificial Sequence <220> <223> v3.2_G <400> 409 gtcacataca ccaccaacat cgaccagctc tgcaaggccg gcaaggtgga tgaggctctg 60 gagctgttcg acgagatgaa ggagagaggc atcaagcccg acgtg 105 <210> 410 <211> 105 <212> DNA <213> Artificial Sequence <220> <223> v3.2_U <400> 410 gtcacataca acaccaacat cgaccagctc tgcaaggccg gcagactgga cgaggccgaa 60 gagctgctgg aggagatgga ggagaagggc atcaagcccg acgtg 105 <210> 411 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR1 <400> 411 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 412 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR2 <400> 412 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1620 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 413 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR3 <400> 413 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 414 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR5 <400> 414 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 415 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR6 <400> 415 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 416 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR7 <400> 416 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 417 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR8 <400> 417 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 660 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 2220 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 418 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR9 <400> 418 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 419 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR10 <400> 419 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 420 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR11 <400> 420 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2040 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 421 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR12 <400> 421 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 2220 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 422 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR13 <400> 422 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 960 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 423 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR14 <400> 423 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 2100 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2160 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 424 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR15 <400> 424 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 425 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR16 <400> 425 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 660 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 720 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 780 agcaagggcg tgaagcccaa cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1140 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1200 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 2220 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 426 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR17 <400> 426 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1080 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1500 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 2220 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 427 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR18 <400> 427 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1080 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1260 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1320 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 1680 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1740 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1800 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 2160 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 2400 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2460 gagaggggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 428 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR19 <400> 428 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 960 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 2340 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 2460 gagaagggca tcaagcccga cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 429 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR20 <400> 429 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 780 gagaagggca tcaagcccga cgtggtgaca tacaccaccc tgatcgacgg cctgtgcaag 840 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 900 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1560 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1620 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1980 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2040 agcaagggcg tgaagcccaa cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 430 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR21 <400> 430 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 660 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1380 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 1440 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1500 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1740 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1920 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 2220 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 2340 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 431 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR22 <400> 431 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 720 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 780 gagaggggca tcaagcccga cgtggtgaca tacaccacac tgatcgacgg actgtgtaaa 840 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 900 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 1080 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1320 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1380 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1680 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1740 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1800 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1920 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1980 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 2040 gagaggggca tcaagcccga cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 2220 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 432 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR23 <400> 432 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 660 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 900 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 960 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1140 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1200 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1260 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1320 cccagcgtgg tcacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1380 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtgaca 1440 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1500 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1560 gacggcctgt gcaaggccgg cagactggat gaggccgagg agctgctgga ggagatggag 1620 gagaagggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacaa caccctgatc gacggcctgt gcaaggccgg cagactggat 1800 gaggccgagg agctgctgga ggagatggag gagaagggca tcaagcccga cgtggtcaca 1860 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1920 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 2100 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 2160 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 2340 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 2400 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 2460 agcaagggcg tgaagcccaa cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 433 <211> 2610 <212> DNA <213> Artificial Sequence <220> <223> v3.1_PPR24 <400> 433 atggccggag tgttcacact ggaggacttc gtgggcgact ggagacagac cgccggctac 60 aacctggacc aggtgctgga gcagggcgga gtgagcagcc tgtttcagaa cctgggcgtg 120 agcgtcaccc ccatccagag gatcgtgctg tccggcgaga atggcctgaa gatcgacatc 180 cacgtcatca tcccctacga gggcctgagc ggcgatcaga tgggccagat cgagaagatc 240 ttcaaggtgg tgtatcccgt cgacgaccac cacttcaagg tgatcctgca ttacggcacc 300 ctcgtgatcg acggcgtgac ccctaacatg atcgactact tcggcaggcc ctacgaggga 360 atcgccgtgt tcgacggaaa gaagatcacc gtgaccggca ccctgtggaa cggaaacaag 420 atcatcgacg agaggctgat caaccccgac ggctccctgc tgttcagggt gaccatcaat 480 ggcgtgaccg gctggagact gtgcgagaga atcctggccg gaggcggagg aagcctcgtg 540 cccagaggat ccggcggagg cggctccagc cggctccata tgggaaactc cgtggtcaca 600 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 660 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tcacatacaa caccctgatc 720 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 780 gagaagggca tcacccccag cgtggtgaca tacaacaccc tgatcgacgg cctgtgcaag 840 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 900 cccagcgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 960 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggttaca 1020 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1080 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac cacactgatc 1140 gacggactgt gtaaagccgg caaggtggac gaagccctcg agctgttcaa agagatgcgg 1200 agcaagggcg tgaagcccaa cgtggttaca tacaccaccc tgatcgacgg cctgtgcaag 1260 gccggcaaag tggacgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 1320 cccgacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 1380 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 1440 tacaacaccc tgatcgacgg cctgtgcaag gccggcagac tggatgaggc cgaggagctg 1500 ctggaggaga tggaggagaa gggcatcaag cccgacgtgg tcacatacac caccctgatc 1560 gacggcctgt gcaaggccgg caaggtggat gaggccctgg agctgttcga cgagatgaag 1620 gagaggggca tcaagcccga cgtggttaca tacaacaccc tgatcgacgg cctgtgcaag 1680 gccggcagac tggatgaggc cgaggagctg ctggaggaga tggaggagaa gggcatcaag 1740 cccgacgtgg tcacatacac caccctgatc gacggcctgt gcaaggccgg caaggtggat 1800 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1860 tacaccacac tgatcgacgg actgtgtaaa gccggcaagg tggacgaagc cctcgagctg 1920 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tcacatacaa caccctgatc 1980 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2040 gagaagggca tcacccccag cgtggttaca tacaccacac tgatcgacgg actgtgtaaa 2100 gccggcaagg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 2160 cccaacgtgg tcacatacac cacactgatc gacggactgt gtaaagccgg caaggtggac 2220 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtgaca 2280 tacaccaccc tgatcgacgg cctgtgcaag gccggcaaag tggacgaggc cctggagctg 2340 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 2400 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 2460 gagaagggca tcacccccag cgagctgacc tacaacaccc tgatcagcgg cctgggcaag 2520 gccggcagag ccagagaccc ccccgtgctc agtagcggct ccggcggcag cgggggaggc 2580 gggcatcatc accatcacca cggacgctag 2610 <210> 434 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR1 <400> 434 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 450 455 460 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 435 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR2 <400> 435 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 515 520 525 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 530 535 540 Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 436 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR3 <400> 436 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 725 730 735 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 740 745 750 Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 770 775 780 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 437 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR5 <400> 437 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 438 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR6 <400> 438 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 439 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR7 <400> 439 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 440 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR8 <400> 440 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 441 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR9 <400> 441 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 725 730 735 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 740 745 750 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 442 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR10 <400> 442 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 443 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR11 <400> 443 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala 660 665 670 Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 444 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR12 <400> 444 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 690 695 700 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 705 710 715 720 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 770 775 780 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 445 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR13 <400> 445 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu 305 310 315 320 Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro 325 330 335 Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 690 695 700 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 705 710 715 720 Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 725 730 735 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 740 745 750 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 446 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR14 <400> 446 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 447 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR15 <400> 447 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 448 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR16 <400> 448 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 210 215 220 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu 385 390 395 400 Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 725 730 735 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 740 745 750 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 449 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR17 <400> 449 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly 340 345 350 Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly 355 360 365 Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 485 490 495 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 450 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR18 <400> 450 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly 355 360 365 Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys 420 425 430 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 565 570 575 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu 595 600 605 Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu 690 695 700 Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys 705 710 715 720 Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 451 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR19 <400> 451 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 770 775 780 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 805 810 815 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 452 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR20 <400> 452 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu 245 250 255 Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 530 535 540 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 453 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR21 <400> 453 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 210 215 220 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu 450 455 460 Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu 565 570 575 Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 770 775 780 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 454 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR22 <400> 454 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 245 250 255 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu 275 280 285 Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu 420 425 430 Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 565 570 575 Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu 595 600 605 Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu 625 630 635 640 Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr 645 650 655 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala 660 665 670 Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys 740 745 750 Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 455 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR23 <400> 455 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 210 215 220 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu 275 280 285 Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val 290 295 300 Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp 305 310 315 320 Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro 325 330 335 Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys 385 390 395 400 Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys 420 425 430 Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys 450 455 460 Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr 465 470 475 480 Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu 485 490 495 Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn 500 505 510 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg 515 520 525 Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu 595 600 605 Met Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 625 630 635 640 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile 690 695 700 Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr 705 710 715 720 Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met 770 775 780 Glu Glu Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 805 810 815 Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 456 <211> 869 <212> PRT <213> Artificial Sequence <220> <223> v3.1_PPR24 <400> 456 Met Ala Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 1 5 10 15 Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 20 25 30 Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 35 40 45 Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 50 55 60 Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 65 70 75 80 Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 85 90 95 His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 100 105 110 Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 115 120 125 Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 130 135 140 Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 145 150 155 160 Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 165 170 175 Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Arg Leu 180 185 190 His Met Gly Asn Ser Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu 195 200 205 Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met 210 215 220 Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn Thr Leu Ile 225 230 235 240 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 245 250 255 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Asn 260 265 270 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 275 280 285 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 290 295 300 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp 305 310 315 320 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 325 330 335 Asn Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 340 345 350 Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly 355 360 365 Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys 370 375 380 Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg 385 390 395 400 Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp 405 410 415 Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp 420 425 430 Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr 435 440 445 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 450 455 460 Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr 465 470 475 480 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Arg Leu Asp Glu 485 490 495 Ala Glu Glu Leu Leu Glu Glu Met Glu Glu Lys Gly Ile Lys Pro Asp 500 505 510 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys 515 520 525 Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile 530 535 540 Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys 545 550 555 560 Ala Gly Arg Leu Asp Glu Ala Glu Glu Leu Leu Glu Glu Met Glu Glu 565 570 575 Lys Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 580 585 590 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 595 600 605 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Thr Thr Leu 610 615 620 Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu 625 630 635 640 Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr 645 650 655 Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala 660 665 670 Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val 675 680 685 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 690 695 700 Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys 705 710 715 720 Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala 725 730 735 Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys 740 745 750 Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 755 760 765 Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met 770 775 780 Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 785 790 795 800 Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe 805 810 815 Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Glu Leu Thr Tyr Asn 820 825 830 Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Ala Arg Asp Pro Pro 835 840 845 Val Leu Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly His His His 850 855 860 His His His Gly Arg 865 <210> 457 <211> 2271 <212> DNA <213> Artificial Sequence <220> <223> v2_polypucleotide <400> 457 atgggtcatc accatcatca tcacgggtcc ctgcaggact cagaagtcaa tcaagaagct 60 aagccagagg tcaagccaga agtcaagcct gagactcaca tcaatttaaa ggtgtccgat 120 ggatcttcag agatcttctt caagatcaaa aagaccactc ctttaagaag gctgatggaa 180 gcgttcgcta aaagacaggg taaggaaatg gactccttaa gattcttgta cgacggtatt 240 agaattcaag ctgatcaggc ccctgaagat ttggacatgg aggataacga tattattgag 300 gctcaccgcg aacagattgg aggtatggga aactccgtgg tcacatacaa caccctgatc 360 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 420 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 480 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 540 cccaacgtgg tgacatacac caccctgatc gacggcctgt gcaaggccgg caaagtggac 600 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 660 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 720 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg ttacatacac cacactgatc 780 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 840 agcaagggcg tgaagcccaa cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 900 gccggcaagg tggatgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 960 cccgacgtgg ttacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1020 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1080 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1140 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tgacatacac caccctgatc 1200 gacggcctgt gcaaggccgg caaagtggac gaggccctgg agctgttcga cgagatgaag 1260 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1320 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1380 cccagcgtgg ttacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1440 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1500 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 1560 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1620 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1680 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1740 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1800 cccaacgtgg ttacatacac caccctgatc gacggcctgt gcaaggccgg caaagtggac 1860 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1920 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1980 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tgacatacac cacactgatc 2040 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2100 agcaagggcg tgaagcccaa cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 2160 gccggcaagg tggatgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2220 cccgacgagc tgacctacaa caccctgatc agcggcctgg gcaaggccgg c 2271 <210> 458 <211> 757 <212> PRT <213> Artificial Sequence <220> <223> v2_protein <400> 458 Met Gly His His His His His His Gly Ser Leu Gln Asp Ser Glu Val 1 5 10 15 Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr 20 25 30 His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys 35 40 45 Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys 50 55 60 Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile 65 70 75 80 Arg Ile Gln Ala Asp Gln Ala Pro Glu Asp Leu Asp Met Glu Asp Asn 85 90 95 Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Met Gly Asn Ser 100 105 110 Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys 115 120 125 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 130 135 140 Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 145 150 155 160 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 165 170 175 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 180 185 190 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 195 200 205 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 210 215 220 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 225 230 235 240 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 245 250 255 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 260 265 270 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 275 280 285 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 290 295 300 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 305 310 315 320 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 325 330 335 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 340 345 350 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 355 360 365 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 370 375 380 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 385 390 395 400 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 405 410 415 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 420 425 430 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 435 440 445 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 450 455 460 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 465 470 475 480 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 485 490 495 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 500 505 510 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 515 520 525 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 530 535 540 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 545 550 555 560 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp 565 570 575 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 580 585 590 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 595 600 605 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 610 615 620 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 625 630 635 640 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 645 650 655 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 660 665 670 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 675 680 685 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 690 695 700 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 705 710 715 720 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 725 730 735 Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly 740 745 750 Leu Gly Lys Ala Gly 755 <210> 459 <211> 2274 <212> DNA <213> Artificial Sequence <220> <223> v3.2_polypucleotide <400> 459 atgggtcatc accatcatca tcacgggtcc ctgcaggact cagaagtcaa tcaagaagct 60 aagccagagg tcaagccaga agtcaagcct gagactcaca tcaatttaaa ggtgtccgat 120 ggatcttcag agatcttctt caagatcaaa aagaccactc ctttaagaag gctgatggaa 180 gcgttcgcta aaagacaggg taaggaaatg gactccttaa gattcttgta cgacggtatt 240 agaattcaag ctgatcaggc ccctgaagat ttggacatgg aggataacga tattattgag 300 gctcaccgcg aacagattgg aggtatggga aactccgtgg tcacatacaa caccaacatc 360 gaccagctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 420 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 480 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 540 cccaacgtgg tgacatacac caccctgatc gacggcctgt gcaaggccgg caaagtggac 600 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 660 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 720 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg ttacatacac cacactgatc 780 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 840 agcaagggcg tgaagcccaa cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 900 gccggcaagg tggatgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 960 cccgacgtgg ttacatacaa caccctgatc gacggcctgt gcaagagcgg caagatcgag 1020 gaggccctga agctgttcaa ggagatggag gagaagggca tcacccccag cgtggtcaca 1080 tacaccacac tgatcgacgg actgtgtaaa gccggcgacg tggacgaagc cctcgagctg 1140 ttcaaagaga tgcggagcaa gggcgtgaag cccaacgtgg tgacatacac caccctgatc 1200 gacggcctgt gcaaggccgg caaagtggac gaggccctgg agctgttcga cgagatgaag 1260 gagaggggca tcaagcccga cgtggtcaca tacaacaccc tgatcgacgg cctgtgcaag 1320 agcggcaaga tcgaggaggc cctgaagctg ttcaaggaga tggaggagaa gggcatcacc 1380 cccagcgtgg ttacatacac cacactgatc gacggactgt gtaaagccgg cgacgtggac 1440 gaagccctcg agctgttcaa agagatgcgg agcaagggcg tgaagcccaa cgtggtcaca 1500 tacaccaccc tgatcgacgg cctgtgcaag gccggcaagg tggatgaggc cctggagctg 1560 ttcgacgaga tgaaggagag gggcatcaag cccgacgtgg tcacatacaa caccctgatc 1620 gacggcctgt gcaagagcgg caagatcgag gaggccctga agctgttcaa ggagatggag 1680 gagaagggca tcacccccag cgtggtcaca tacaccacac tgatcgacgg actgtgtaaa 1740 gccggcgacg tggacgaagc cctcgagctg ttcaaagaga tgcggagcaa gggcgtgaag 1800 cccaacgtgg ttacatacac caccctgatc gacggcctgt gcaaggccgg caaagtggac 1860 gaggccctgg agctgttcga cgagatgaag gagaggggca tcaagcccga cgtggtcaca 1920 tacaacaccc tgatcgacgg cctgtgcaag agcggcaaga tcgaggaggc cctgaagctg 1980 ttcaaggaga tggaggagaa gggcatcacc cccagcgtgg tgacatacac cacactgatc 2040 gacggactgt gtaaagccgg cgacgtggac gaagccctcg agctgttcaa agagatgcgg 2100 agcaagggcg tgaagcccaa cgtggtcaca tacaccaccc tgatcgacgg cctgtgcaag 2160 gccggcaagg tggatgaggc cctggagctg ttcgacgaga tgaaggagag gggcatcaag 2220 cccgacgagg agctgaccta caacaccctg atcagcggcc tgggcaaggc cggc 2274 <210> 460 <211> 757 <212> PRT <213> Artificial Sequence <220> <223> v3.2_protein <400> 460 Met Gly His His His His His His Gly Ser Leu Gln Asp Ser Glu Val 1 5 10 15 Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr 20 25 30 His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys 35 40 45 Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys 50 55 60 Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile 65 70 75 80 Arg Ile Gln Ala Asp Gln Ala Pro Glu Asp Leu Asp Met Glu Asp Asn 85 90 95 Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Met Gly Asn Ser 100 105 110 Val Val Thr Tyr Asn Thr Asn Ile Asp Gln Leu Cys Lys Ser Gly Lys 115 120 125 Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile 130 135 140 Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 145 150 155 160 Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser 165 170 175 Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly 180 185 190 Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu 195 200 205 Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu 210 215 220 Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu 225 230 235 240 Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr 245 250 255 Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala 260 265 270 Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val 275 280 285 Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val 290 295 300 Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys 305 310 315 320 Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser 325 330 335 Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys 340 345 350 Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu 355 360 365 Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met 370 375 380 Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile 385 390 395 400 Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe 405 410 415 Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr Tyr Asn 420 425 430 Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu Ala Leu 435 440 445 Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser Val Val 450 455 460 Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp Val Asp 465 470 475 480 Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val Lys Pro 485 490 495 Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly 500 505 510 Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu Arg Gly 515 520 525 Ile Lys Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Asp Gly Leu Cys 530 535 540 Lys Ser Gly Lys Ile Glu Glu Ala Leu Lys Leu Phe Lys Glu Met Glu 545 550 555 560 Glu Lys Gly Ile Thr Pro Ser Val Val Thr Tyr Thr Thr Leu Ile Asp 565 570 575 Gly Leu Cys Lys Ala Gly Asp Val Asp Glu Ala Leu Glu Leu Phe Lys 580 585 590 Glu Met Arg Ser Lys Gly Val Lys Pro Asn Val Val Thr Tyr Thr Thr 595 600 605 Leu Ile Asp Gly Leu Cys Lys Ala Gly Lys Val Asp Glu Ala Leu Glu 610 615 620 Leu Phe Asp Glu Met Lys Glu Arg Gly Ile Lys Pro Asp Val Val Thr 625 630 635 640 Tyr Asn Thr Leu Ile Asp Gly Leu Cys Lys Ser Gly Lys Ile Glu Glu 645 650 655 Ala Leu Lys Leu Phe Lys Glu Met Glu Glu Lys Gly Ile Thr Pro Ser 660 665 670 Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys Ala Gly Asp 675 680 685 Val Asp Glu Ala Leu Glu Leu Phe Lys Glu Met Arg Ser Lys Gly Val 690 695 700 Lys Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Asp Gly Leu Cys Lys 705 710 715 720 Ala Gly Lys Val Asp Glu Ala Leu Glu Leu Phe Asp Glu Met Lys Glu 725 730 735 Arg Gly Ile Lys Pro Asp Glu Leu Thr Tyr Asn Thr Leu Ile Ser Gly 740 745 750 Leu Gly Lys Ala Gly 755

Claims

다음 중 어느 하나의 PPR 모티프:
(A-1) 서열번호 9의 서열로 구성되는 PPR 모티프, 또는 서열번호 9의 서열에있어서 10번 위치 아미노산의 티로신으로의 치환, 15번 위치 아미노산의 리신으로의 치환, 16번 위치 아미노산의 류신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 18번 위치 아미노산의 아스파라긴산으로의 치환, 및 28번 위치 아미노산의 글루탐산으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프,
또는 서열번호 401의 서열로 구성되는 PPR 모티프, 서열번호 401의 서열에 있어서 10번 위치 아미노산의 티로신으로의 치환, 16번 위치 아미노산의 류신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 18번 위치 아미노산의 아스파라긴산으로의 치환, 및 28번 위치 아미노산의 글루탐산으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프;
(A-2) 서열번호 9 또는 401의 서열에 있어서 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1 내지 20개가 치환, 결실 또는 부가된 서열로 이루어지고 아데닌 결합성인 PPR 모티프;
(A-3) 서열번호 9 또는 401의 서열과 최소한 42%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 아데닌 결합성인 PPR 모티프;
(C-1) 서열번호 10의 서열로 구성되는 PPR 모티프, 또는 서열번호 10의 서열에 있어서 2번 위치 아미노산의 세린으로의 치환, 5번 위치 아미노산의 이소류신으로의 치환, 7번 위치 아미노산의 이소류신으로의 치환, 8번 위치 아미노산의 리신으로의 치환, 10번 위치 아미노산의 페닐알라닌 또는 티로신으로의 치환, 15번 위치 아미노산의 아르기닌으로의 치환, 22번 위치 아미노산의 발린으로의 치환, 24번 위치 아미노산의 아르기닌으로의 치환, 27번 위치 아미노산의 아르기닌으로의 치환, 및 29번 위치 아미노산의 아르기닌으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프;
(C-2) 서열번호 10의 서열에 있어서 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 25개가 치환, 결실 또는 부가된 서열로 이루어지고 시토신 결합성인 PPR 모티프;
(C-3) 서열번호 10의 서열과 최소한 25%의 서열 동일성을 가지되, 1, 3, 4, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 시토신 결합성인 PPR 모티프;
(G-1) 서열번호 11의 서열로 구성되는 PPR 모티프, 또는 서열번호 11의 서열에 있어서 10번 위치 아미노산의 페닐알라닌으로의 치환, 15번 위치 아미노산의 아스파라긴산으로의 치환, 27번 위치 아미노산의 발린으로의 치환, 28번 위치 아미노산의 세린으로의 치환, 및 35번 위치 아미노산의 이소류신으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산으로 구성된 PPR 모티프;
(G-2) 서열번호 11의 서열에 있어서 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 2개가 치환, 결실 또는 부가된 서열로 이루어지고 구아닌 결합성인 PPR 모티프;
(G-3) 서열번호 11의 서열과 최소한 40%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 7, 9, 14, 18, 19, 26, 30, 33, 및 34번 위치의 아미노산은 동일하고 구아닌 결합성인 PPR 모티프;
(U-1) 서열번호 12의 서열로 구성되는 PPR 모티프, 또는 서열번호 12의 서열에 있어서 10번 위치 아미노산의 페닐알라닌으로의 치환, 13번 위치 아미노산의 세린으로의 치환, 15번 위치 아미노산의 리신으로의 치환, 17번 위치 아미노산의 글루탐산으로의 치환, 20번 위치 아미노산의 류신으로의 치환, 21번 위치 아미노산의 리신으로의 치환, 23번 위치 아미노산의 페닐알라닌으로의 치환, 24번 위치 아미노산의 아스파라긴산으로의 치환, 27번 위치 아미노산의 리신으로의 치환, 28번 위치 아미노산의 리신으로의 치환, 29번 위치 아미노산의 아르기닌으로의 치환 및 31번 위치 아미노산의 류신으로의 치환으로 이루어진 군으로부터 선택되는 어느 하나의 치환을 행한 아미노산 서열로 구성되는 PPR 모티프;
(U-2) 서열번호 12의 서열에 있어서 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 22개가 치환, 결실 또는 부가된 서열로 이루어지고 우라실 결합성인 PPR 모티프;
(U-3) 서열번호 12의 서열과 최소한 37%의 서열 동일성을 가지되, 1, 2, 3, 4, 6, 11, 12, 14, 19, 26, 30, 33, 및 34번 위치 아미노산은 동일하고 우라실 결합성인 PPR 모티프.
제1항에 기재된 PPR 모티프의, 표적 RNA가 15개의 염기 길이 이상인 PPR 단백질의 작제를 위한 용도.
제1항에 기재된 PPR 모티프의 PPR 단백질 작제를 위한 용도에 있어서, PPR 단백질의 표적 RNA에 대한 결합능력을 높이기 위한 것을 특징으로 하는 용도.
n개의 염기서열로 이루어진 표적 RNA에 결합 가능한 n개의 PPR 모티프를 포함하는 단백질로서,
해당 염기서열 중의 아데닌에 대한 PPR 모티프가 제1항에 정의된 (A-1), (A-2), 또는 (A-3)의 PPR 모티프이고;
해당 염기서열 중의 시토신에 대한 PPR 모티프가 제1항에 정의된 (C-1), (C-2), 또는 (C-3)의 PPR 모티프이며;
해당 염기서열 중의 구아닌에 대한 PPR 모티프가 제1항에 정의된 (G-1), (G-2), 또는 (G-3)의 PPR 모티프이고;
해당 염기서열 중의 우라실에 대한 PPR 모티프가 제1항에 정의된 (U-1), (U-2), 또는 (U-3)의 PPR 모티프인 PPR 단백질.
제4항에 있어서,
n이 15 이상인 것을 특징으로 하는 단백질.
제4항 또는 제5항에 있어서,
N-말단에서 1번째 PPR 모티프가 다음 중 어느 하나인 것을 특징으로 하는 단백질:
(1st_A-1) 서열번호 402의 서열에 있어서 6번 및 9번 위치의 아미노산이 이하에 정의된 조합의 어느 하나를 만족하도록 치환된 PPR 모티프;
(1st_A-2) (1st_A-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 아데닌 결합성인 PPR 모티프;
(1st_A-3) (1st_A-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 아데닌 결합성인 PPR 모티프;
(1st_C-1) 서열번호 403의 서열로 구성되는 PPR 모티프;
(1st_C-2) (1st_C-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 시토신 결합성인 PPR 모티프;
(1st_C-3) (1st_C-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 시토신 결합성인 PPR 모티프;
(1st_G-1) 서열번호 404의 서열에 있어서 6번 및 9번 위치의 아미노산이 이하에 정의된 조합 중 어느 하나를 만족하도록 치환된 서열로 구성되는 PPR 모티프;
(1st_G-2) (1st_G-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 구아닌 결합성인 PPR 모티프;
(1st_G-3) (1st_G-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 구아닌 결합성인 PPR 모티프;
(1st_U-1) 서열번호 405의 서열에 있어서 6번 및 9번 위치의 아미노산이 이하에 정의된 조합의 어느 하나를 만족하도록 치환된 서열로 구성되는 PPR 모티프;
(1st_U-2)(1st_U-1)의 서열에 있어서 1, 4, 6, 9, 및 34번 위치 아미노산 이외의 아미노산 1개 내지 9개가 치환, 결실 또는 부가된 서열로 이루어지고 우라실 결합성인 PPR 모티프;
(1st_U-3) (1st_U-1)의 서열과 최소한 80%의 서열 동일성을 가지되, 1, 4, 6, 9, 및 34번 위치의 아미노산은 동일하고 우라실 결합성인 PPR 모티프
·6번 위치의 아미노산이 아스파라긴이고, 9번 위치의 아미노산이 글루탐산인 조합
·6번 위치의 아미노산이 아스파라긴이고, 9번 위치의 아미노산이 글루타민인 조합
·6번 위치의 아미노산이 아스파라긴이고, 9번 위치의 아미노산이 리신인 조합
·6번 위치의 아미노산 아스파라긴산이고, 9번 위치의 아미노산이 글리신인 조합.
제4항 내지 제6항의 어느 한 항에 기재된 단백질을 이용하는 것을 특징으로 하는 RNA 접합의 제어방법.
제4항 내지 제6항의 어느 한 항에 기재된 단백질을 이용하는 것을 특징으로 하는 RNA의 검출방법.
형광 단백질, 핵이행 신호 펩티드 및 태그 단백질로 이루어진 군으로부터 선택되는 적어도 하나와 제4항 내지 제6항의 어느 한 항에 기재된 단백질과의 융합 단백질.
제1항에 기재된 PPR 모티프, 또는 제4항 내지 제6항의 어느 한 항에 기재된 단백질을 암호화하는 핵산.
제10항에 기재된 핵산을 포함하는 벡터.
제11항에 기재된 벡터를 포함하는 세포(인간 개체는 제외).
제1항에 기재된 PPR 모티프, 제4항 내지 제6항의 어느 한 항에 기재된 단백질, 또는 제11항에 기재된 벡터를 이용하는 것을 특징으로 하는 RNA의 조작방법(인간 개체에서의 실시를 제외한다).
제13항에 기재된 조작방법을 포함하는 것을 특징으로 하는 생물의 생산방법.