KR20220015013A - 싸리속 식물 추출물을 포함하는 피부 볼륨 증가용 조성물 - Google Patents
싸리속 식물 추출물을 포함하는 피부 볼륨 증가용 조성물 Download PDFInfo
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- KR20220015013A KR20220015013A KR1020200094987A KR20200094987A KR20220015013A KR 20220015013 A KR20220015013 A KR 20220015013A KR 1020200094987 A KR1020200094987 A KR 1020200094987A KR 20200094987 A KR20200094987 A KR 20200094987A KR 20220015013 A KR20220015013 A KR 20220015013A
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- lespedeza
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- buciclovir
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Abstract
본 발명에 따른 비수리, 부시클로버 또는 싸리 추출물을 유효성분으로 포함하는 조성물은 지방세포의 증식 및 지방세포로의 분화를 촉진함으로써 피하 지방층을 구성하거나, 지방세포를 제공하여 지방 조직이 증가됨으로써 함몰되거나 확대가 필요한 피부 조직의 부피를 수복 및 확대시킬 수 있다. 따라서, 본 발명에 따른 싸리속 식물 추출물을 유효성분으로 포함하는 지방세포의 증식 및 지방세포로의 분화를 촉진하는 조성물은 피부 부피의 수복 및 확대용 화장료 조성물, 피부 볼륨감 증대용 피부외용제 조성물 또는 피부 볼륨감 증대용 성형용 조성물로서 유용하게 사용될 수 있다.
Description
도 2는 본 발명의 비수리, 부시클로버 및 싸리 추출물에 의한 지방세포의 세포증식을 수치화한 그래프이다.
도 3은 본 발명의 비수리, 부시클로버 및 싸리 추출물에 의한 3T3-L1 지방전구세포의 지방세포 분화 촉진을 오일 레드 오(Oil-red O) 염색법으로 관찰한 결과이다.
도 4는 본 발명의 비수리, 부시클로버 및 싸리 추출물에 의한 3T3-L1 지방전구세포의 지방세포 분화 촉진을 수치화한 그래프이다.
성분 | 함량 (%) | |
대조군 | 시험군 | |
정제수 | 72 | 71 |
글리세린 | 8.0 | 8.0 |
부틸렌글리콜 | 4.0 | 4.0 |
싸리속 식물 추출물 (70% EtOH) | 0 | 1.0 |
카프릴릭/카프리 트리글리세라이드 | 8.0 | 8.0 |
스쿠알란 | 5.0 | 5.0 |
세테아릴 글루쿠사이드 | 1.5 | 1.5 |
소르비탄 스테아레이트 | 0.4 | 0.4 |
세테아릴 알코올 | 1.0 | 1.0 |
트리메탄올아민 | 0.1 | 0.1 |
총중량 | 100 | 100 |
시험물질 | 반응이 나타난 피검자 수 | 평균반응도 | ||||||||
1주 | 2주 | 3주 | ||||||||
1차 | 2차 | 3차 | 4차 | 5차 | 6차 | 7차 | 8차 | 9차 | ||
± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ||
대조군 | - - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.00 |
시험군(비수리) | - - - | 1 - - | 1 - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.19 |
시험군(부시클로버) | - - - | - - - | 1 - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.09 |
시험군(싸리) | 1 - - | 1 - - | 1 - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.28 |
피검인원 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 |
성분 | 중량% |
싸리속 식물 추출물 | 0.01 |
글리세린 | 3.0 |
부틸렌 글리콜 | 2.0 |
프로필렌 글리콜 | 2.0 |
카복시비닐폴리머 | 0.1 |
에탄올 | 10.0 |
트리에탄올아민 | 0.1 |
방부제, 미량색소, 미량향료 및 미량 정제수 | 82.79 |
총계 | 100.0 |
성분 | 중량% |
싸리속 식물 추출물 | 0.01 |
밀납 | 4.0 |
폴리소르베이트 60 | 1.5 |
소르비탄세스퀴올레이트 | 0.5 |
유동파라핀 | 5.0 |
스쿠알란 | 5.0 |
카프릴릭/카프릭 트리글리세라이드 | 5.0 |
글리세린 | 3.0 |
부틸렌 글리콜 | 3.0 |
프로필렌 글리콜 | 3.0 |
카복시비닐폴리머 | 0.1 |
트리에탄올아민 | 0.2 |
방부제, 미량색소, 미량향료 및 미량정제수 | 69.69 |
총계 | 100.0 |
성분 | 중량% |
싸리속 식물 추출물 | 0.01 |
밀납 | 10.0 |
폴리소르베이트 60 | 1.5 |
소르비탄세스퀴올레이트 | 0.5 |
유동파라핀 | 10.0 |
스쿠알란 | 5.0 |
카프릴릭/카프릭 트리글리세라이드 | 5.0 |
글리세린 | 5.0 |
부틸렌 글리콜 | 3.0 |
프로필렌 글리콜 | 3.0 |
트리에탄올아민 | 0.2 |
방부제, 미량색소, 미량향료 및 미량정제수 | 56.79 |
총계 | 100.0 |
성분 | 중량% |
싸리속 식물 추출물 | 0.01 |
밀납 | 10.0 |
폴리소르베이트 60 | 1.5 |
소르비탄세스퀴올레이트 | 0.8 |
유동파라핀 | 40.0 |
스쿠알란 | 5.0 |
카프릴릭/카프릭 트리글리세라이드 | 4.0 |
글리세린 | 5.0 |
부틸렌 글리콜 | 3.0 |
프로필렌 글리콜 | 3.0 |
트리에탄올아민 | 0.2 |
방부제, 미량색소, 미량향료 및 미량정제수 | 27.49 |
총계 | 100.0 |
성분 | 중량% |
싸리속 식물 추출물 | 0.01 |
폴리비닐알콜 | 13.0 |
소듐카복시메틸셀룰로스 | 0.2 |
알란토인 | 0.1 |
에탄올 | 5.0 |
노닐페닐에테르 | 0.3 |
방부제, 미량색소, 미량향료 및 미량정제수 | 81.39 |
총계 | 100.0 |
성분 | 함량(g) |
싸리속 식물 추출물 | 2 |
유당 | 1 |
성분 | 함량(㎎) |
싸리속 식물 추출물 | 100 |
옥수수전분 | 100 |
유당 | 100 |
스테아린산마그네슘 | 2 |
성분 | 함량(㎎) |
싸리속 식물 추출물 | 100 |
옥수수전분 | 100 |
유당 | 100 |
스테아린산마그네슘 | 2 |
성분 | 중량% |
싸리속 식물 추출물 | 1.00 |
부틸렌글라이콜 | 2.00 |
글리세린 | 1.00 |
디소듐이디티에이 | 0.02 |
PEG-60 하이드로제네이티드캐스터오일 | 1.00 |
코카미도프로필베타인 | 4.00 |
라우릴 글루코사이드 | 6.00 |
폴리소르베이트 20 | 1.00 |
소듐벤조에이트 | 0.40 |
카프릴릭글라이콜 | 0.20 |
소듐락테이트 | 0.50 |
하이드록시에틸셀룰로오스 | 0.7 |
정제수 | 82.18 |
총계 | 100.0 |
성분 | 중량% |
싸리속 식물 추출물 | 1.0 |
디에탄올아민 | 1.5 |
폴리비닐프톨리돈 | 5.0 |
프로필렌글리콜 | 30.0 |
정제수 | 62.5 |
총계 | 100.0 |
Claims (8)
- 비수리(Lespedeza cuneate), 부시클로버(Leapedeza capitata) 및 싸리추출물 (Lespedeza bicolor)로 이루어진 군에서 선택된 하나 이상의 싸리속(Lespadeza sp.) 식물 추출물을 유효성분으로 포함하는 피부 부피의 수복 또는 확대용 화장료 조성물.
- 제1항에 있어서, 상기 피부가 코, 광대, 볼, 이마, 팔자부위, 눈밑, 가슴 또는 엉덩이 부위의 피부인 것인, 화장료 조성물.
- 제1항에 있어서, 상기 조성물은 지방세포 증식 또는 지방세포 분화 촉진용인, 화장료 조성물.
- 제1항에 있어서, 상기 조성물은 피부 주름 개선용인, 화장료 조성물.
- 제1항에 있어서, 상기 조성물은 피부 탄력 증가용인, 화장료 조성물.
- 제1항에 있어서, 상기 추출물은 조성물 전체 중량에 대하여 0.00001 내지 15 중량%로 포함되는 것인, 화장료 조성물.
- 비수리(Lespedeza cuneate), 부시클로버(Leapedeza capitata) 및 싸리추출물 (Lespedeza bicolor)로 이루어진 군에서 선택된 하나 이상의 싸리속(Lespadeza sp.) 식물 추출물을 유효성분으로 포함하는 피부 볼륨감 증대용 피부외용제 조성물.
- 비수리(Lespedeza cuneate), 부시클로버(Leapedeza capitata) 및 싸리추출물 (Lespedeza bicolor)로로 이루어진 군에서 선택된 하나 이상의 싸리속(Lespadeza sp.) 식물 추출물을 유효성분으로 포함하는 피부 볼륨감 증대용 성형용 조성물.
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102576331B1 (ko) * | 2023-05-03 | 2023-09-08 | 장연식 | 국소지방 제거용 주사제 조성물 및 그 시술방법 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003034631A (ja) * | 2001-07-17 | 2003-02-07 | Koei Kogyo Kk | 線維芽細胞増殖促進剤及び抗老化用化粧料 |
KR20140123371A (ko) * | 2013-04-12 | 2014-10-22 | 재단법인 대구테크노파크 | 야관문lpc 추출물을 함유하는 피부광노화 개선기능성 화장료 조성물 |
KR20150029853A (ko) * | 2013-09-10 | 2015-03-19 | 단국대학교 산학협력단 | 싸리 추출물 또는 싸리 추출물 및 토복령 추출물의 혼합물을 포함하는 비만 예방, 치료 또는 개선용 조성물 |
KR20150081221A (ko) * | 2014-01-03 | 2015-07-13 | 배일한 | 상백피, 생강나무 및 야관문 추출물을 유효성분으로 함유하는 주름개선용 화장료 조성물 |
-
2020
- 2020-07-30 KR KR1020200094987A patent/KR102386118B1/ko active IP Right Grant
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003034631A (ja) * | 2001-07-17 | 2003-02-07 | Koei Kogyo Kk | 線維芽細胞増殖促進剤及び抗老化用化粧料 |
KR20140123371A (ko) * | 2013-04-12 | 2014-10-22 | 재단법인 대구테크노파크 | 야관문lpc 추출물을 함유하는 피부광노화 개선기능성 화장료 조성물 |
KR20150029853A (ko) * | 2013-09-10 | 2015-03-19 | 단국대학교 산학협력단 | 싸리 추출물 또는 싸리 추출물 및 토복령 추출물의 혼합물을 포함하는 비만 예방, 치료 또는 개선용 조성물 |
KR20150081221A (ko) * | 2014-01-03 | 2015-07-13 | 배일한 | 상백피, 생강나무 및 야관문 추출물을 유효성분으로 함유하는 주름개선용 화장료 조성물 |
Non-Patent Citations (4)
Title |
---|
Fulton JE et al., Dermatol Clin., 19(3): 523-530, 2001 |
Ha SJ et al., Food & Function, 9(4):2090-2101, 2018 |
S Eremia et al., Dermatol Surg., 26(12):1150-1158, 2000 |
이재학 외 1명. 싸리나무(Lespedeza bicolor) 부위별 추출물의 항산화 활성 및 항산화물질 분리. 한국식품과학회지, Vol. 44, No. 6, pp. 763~771 (2012)* * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102576331B1 (ko) * | 2023-05-03 | 2023-09-08 | 장연식 | 국소지방 제거용 주사제 조성물 및 그 시술방법 |
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