KR20200059932A - A patch for oral cavity - Google Patents

Abstract

An oral patch according to the present invention contains an active component, and comprises: an adhesive part which completely dissolves by saliva; and a non-adhesive part which is located on one side of the adhesive part and can be removed in the oral cavity earlier than the adhesive part to not interfere the active component from being released into the oral cavity. The present invention can solve the hassle of detachment because a user does not need to detach the oral patch separately.

Description

Oral patch {A PATCH FOR ORAL CAVITY}

The present invention relates to an oral patch containing an active substance that can prevent or treat oral diseases while being adhered to the oral cavity.

Oral disease due to the westernization of diet is increasing, and with the increase of the elderly population in Korea, the cost of medical treatment for gum disease, a typical senile oral disease, is also increasing.

The personal and social burdens associated with oral diseases are exacerbated, and two oral-related illnesses are included in the ranking of domestic outpatient treatment frequent illnesses, of which 1st is dental and periodontal disease, and 12th is dental caries. (Cavity).

Although the importance of early prevention and treatment of oral diseases is increasing, there is currently no satisfactory prevention and treatment for gum disease and dry mouth.

Since commercially available products do not have a biofilm control function existing in the oral cavity that causes oral diseases, it is difficult to expect a fundamental prevention and treatment effect.

For example, commercially available products related to gum disease have only the effect of temporarily reducing inflammation as a steroid-like ingredient, and prevention products related to dental caries (cavity) include xylitol gum, fluoride-enhanced toothpaste, and gargles. It has no preventive effect.

Recently, a patch for sensitizing mucosa that can be directly attached to the oral cavity has been introduced. These patches are formed with a hydrophobic support on one side and a hydrophilic fibrous support on the other side, preventing the penetration of saliva through the hydrophobic side and the release of the drug into the oral cavity and directing the drug for the prevention or treatment of diseases in the oral cavity directly to the mucous membrane. It is a method of absorption.

In addition, a tooth-adhesive preparation with improved usability that can be attached to teeth has been introduced. Such a patch has a feature of attaching to a tooth, delivering a drug to the tooth, and dissolving by saliva in the oral cavity, which does not need to be removed.

However, these patches are not suitable for the prevention or treatment of oral diseases, such as the removal of bad breath, which requires the release of active substances into the oral cavity, since the drug exerts a physiological function by being absorbed into the mucous membrane or teeth.

Thus, the present inventor has a long-term effect on the prevention or treatment of oral diseases, and even if the active substances for preventing or treating oral diseases are not directly absorbed into the mucosa, the active substances for preventing or treating oral diseases are ingested, and saliva An oral patch that completely dissolves and does not need to be removed has been developed.

Korean Patent Publication No. 10-2016-0108703 (Public, 2016.09.20.) Korean Patent Registration No. 10-0647974 (Announcement, Nov. 23, 2006)

The technical problem to be achieved by the present invention is to provide an oral patch capable of releasing an active substance that can prevent or treat oral diseases for a long period of time while being adhered to the oral cavity.

In order to solve this problem, the oral patch according to the embodiment of the present invention comprises an adhesive portion formed of a water-soluble hydrocolloid preparation; And a non-adhesive portion located on one side of the adhesive portion and formed of vegetable fat that exists as a solid at room temperature and melts at oral temperature.

The vegetable fat may be palm oil or cocoa butter.

The vegetable fat may have a melting point of 30 degrees to 37 degrees.

The vegetable fat may include saturated fatty acids.

The adhesive portion may further include an active material.

The active material may include any one or more of zinc compounds, vitamins, natural extracts, antifungal agents, anti-inflammatory agents, anesthetics, and antibacterial agents.

The active material may be released into the oral cavity in one direction of the adhesive portion after the non-adhesive portion is dissolved in the oral cavity.

The other side of the adhesive portion may be dissolved by oral saliva to adhere to any one of the oral mucosa, gums, or teeth.

The non-adhesive portion may melt faster than the adhesive portion in the oral cavity.

The adhesive portion may further include a peeling portion located on the other surface.

The peeling portion is detached from the adhesive portion, and may be formed of a water-insoluble and water-impermeable polymer.

According to the present invention as described above has the following effects.

In the present invention, as the oral patch is dissolved by saliva in the oral cavity, active substances such as zinc compounds and vitamins are continuously released into the oral cavity for a long period of time to be taken with saliva to prevent or treat oral diseases.

According to the present invention, a non-adhesive portion that is first removed from the oral cavity than the adhesive portion is formed on one side of the adhesive portion, so that an active substance contained in the adhesive portion can be prevented from being discharged before the user uses the oral patch. (A) After adhering to the oral mucosa, the non-adhesive portion is immediately melted and the active substance may be released into the oral cavity.

The oral patch according to the present invention is made of substances in which the mucosal portion is dissolved by saliva in the oral cavity, and is completely dissolved by itself after attaching to any one of the oral mucosa, gums, or teeth, so that the user does not need to separate and detach it. You can solve the hassle of

In addition, other features and advantages of the present invention may be newly identified through embodiments of the present invention.

1 is a schematic cross-sectional view of an oral patch according to an embodiment of the present invention.
FIG. 2 is a cross-sectional view taken along line A-A 'of the oral patch shown in FIG. 1.
Figure 3 is a view showing an example of attaching the oral patch according to the invention to the oral mucosa of the upper jaw.
4 is a schematic cross-sectional view of an oral patch according to another embodiment of the present invention.
5 is a view showing an example in which the active material of the oral patch according to the present invention is released into the oral cavity.
6 is a schematic cross-sectional view of an oral patch for another embodiment of the present invention.
7 is a graph showing the results of measuring zinc concentration in the oral cavity after using Examples 1 and 2 and Comparative Examples 1 and 2.
8 is a graph showing the results of measurement of bad breath concentration in the oral cavity after using Examples 1 and 2 and Comparative Examples 1 and 2.

It should be noted that in this specification, when adding reference numerals to components of each drawing, the same components have the same number as possible, even if they are displayed on different drawings.

On the other hand, the meaning of the terms described in this specification should be understood as follows.

It should be understood that terms such as “include” or “have” do not preclude the existence or addition possibility of one or more other features or numbers, steps, actions, components, parts or combinations thereof.

The term "on" is meant to include not only the case where a certain component is formed on the upper surface of another component, but also when a third component is interposed between these components.

The term "patch" refers to an adhesive formulation containing a specific component, and the shape or structure of the patch is not particularly limited.

Hereinafter, preferred embodiments of the present invention designed to solve the above problems will be described in detail with reference to the accompanying drawings.

1 is a schematic cross-sectional view of an oral patch according to an embodiment of the present invention, FIG. 2 is a cross-sectional view taken along line A-A 'of the oral patch shown in FIG. 1, and FIG. 3 is an oral patch according to the present invention. It is a view showing an example attached to the upper jaw oral mucosa, Figure 4 is a schematic cross-sectional view of an oral patch according to another embodiment of the present invention, Figure 5 is the active material of the oral patch according to the present invention released into the oral cavity It is a diagram showing an example that is.

1 to 3, the oral patch 1000 according to the present invention includes an adhesive portion 100 and a non-adhesive portion 200 positioned on one surface of the adhesive portion 100.

The adhesive portion 100 includes an active material 110 for the prevention or treatment of oral diseases, and may be adhered to any one of the oral mucosa 10, gums, or teeth.

In one embodiment, the active material 110 may be made of any one of zinc compounds, vitamins, natural extracts with antibacterial and anti-biofilm activity against oral pathogens, antifungal agents, anti-inflammatory agents, anesthetics, and antibacterial agents, but are not limited thereto. It is not particularly limited as long as it is a substance for the purpose of preventing and treating oral diseases.

For example, zinc compounds include zinc chloride, zinc sulfate, zinc gluconate, zinc acetate, zinc citrate, zinc chelating, zinc salicylate, zinc nitrate, zinc oxide, zinc stearate, zinc carbonate (zinc carbonate), zinc oleate, zinc fluoride, zinc acetate, zinc formate, zinc lactate, zinc ammonium sulfate ammonium sulfate), zinc nitrate, zinc sulfonate, zinc chloride, zinc sulfate, zinc citrate, zinc glycerophosphate , Zinc tartarate, or zinc composites thereof.

Zinc reacts with volatile sulfide (VSC) to form insoluble, odorless zinc sulfide, and can reduce the number of microorganisms in the oral cavity through antibacterial action, and the thiol group (-SH, a precursor of volatile sulfide (VSC)) ) By suppressing production, it is effective in preventing bad breath and removing bad breath. In addition, zinc plays an essential role in cell differentiation and proliferation, and thus plays an important role in growth, tissue and skeletal formation, reproductive and immune functions, and may delay the aging of the skin through the sulfation of zinc.

At this time, when the effective substance of the oral patch 1000 according to the present invention is a zinc compound, it is preferable to form the zinc compound in a content of 1 mg or more and 30 mg or less.

If zinc is less than 1 mg in the zinc compound, the effect of preventing bad breath and removing bad breath may decrease, and if it exceeds 30 mg, it may cause side effects due to excessive consumption of zinc.

In one embodiment, when the active material 110 is vitamin, it may be vitamin B12 or vitamin A.

Vitamin B12 is a water-soluble vitamin, called cobalamin, and is an essential component for red blood cell production, neurological function, and DNA synthesis. It acts as a cofactor of methionine synthesis and L-methylmalonyl-coenzyme A-mutase synthesis. do. In addition, it is a component necessary for maintaining myelin (myelin) for nerve function.

In particular, when vitamin B12 deficiency, symptoms of neurological disorders such as tingling, numbness, movement disorders, and cognitive impairment may appear at the ends of the body.

In addition, vitamin A is an effective substance for the treatment of periodontitis.

In one embodiment, when the active material 110 is a natural extract, stool, brown flower, self-designated, motherwort, red bean flower, choo, motherwort, astragalus, ginseng, amethyst (anemarrhena), gardenia, gold anemone, branch, , Goryanggang, Overdose, Hwapi, Blue Box, Chunnyeonja, Johyup, Bongseonhwa, Golden / Wooden Peel, Inflorescence, Licorice, Clove, Branch, White Paper, Wolfberry, Pine Needle, Butterfly Flower, Menthol, EM, Sapindus mukurossi Gaerth , Plum, pork potato, persimmon, amaranth, cassava, purslane, parsley, chives, fermented herbs, may be a natural extract isolated from any one of the aftertaste.

In one embodiment, when the active material 110 is an antifungal agent, it may be any one of nystatin, fluconazole, and itraconazole.

In one embodiment, when the active substance 110 is an anti-inflammatory agent, it may be any one of a steroid-based (aspirin ibuprofen), acetaminophen, and a steroid-based (prednisolone).

In one embodiment, when the active substance 110 is an anesthetic, it may be any one of lidocaine, procaine, bupivacaine, and in the case of an antibacterial agent, it may be CPC (cetiiripyridinium).

One side 130 of the adhesive portion 100 is a release surface from which the active material 110 is released, and the other side 150 of the adhesive portion 100 is adhered to any one of the mucous membrane 10, gums, or teeth in the oral cavity It is an adhesive side.

The adhesive portion 100 is a biodegradable adhesive material that is gradually completely dissolved by contact of saliva or tongue in the oral cavity, and is partially dissolved by saliva in the oral cavity and can be adhered to any one of the oral mucosa 10, gums, or teeth. It can be done.

Referring to FIG. 3, when the adhesive surface 150 of the oral patch 1000 is pressed for 2 to 3 seconds to face the oral mucosa 10 or the teeth, the adhesive portion 100 is partially dissolved in saliva in the oral cavity and the oral mucosa ( 10), can be adhered to either the gums or teeth.

The biodegradable adhesive material included in the adhesive portion 100 forms a gel or viscous solution in an aqueous system. As the biodegradable adhesive material, various adhesive materials known as materials that increase adhesion to a surface can be used, and in particular, a biodegradable water-soluble polymer that can be degraded in a living body including cells or tissues can be used.

An example of such a material may be made of a water-soluble hydrocolloid preparation, but is not limited thereto, and a biodegradable water-soluble polymer may be used.

The water-soluble hydrocolloid preparation may include a water-soluble cellulose derivative or carrageenan. As the cellulose derivative, for example, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carboxymethyl cellulose, or a polymer based on polymethacrylic acid such as polyethylene glycol (PEG), polymethacrylic acid, poly-2 -Hydroxyethyl methacrylic acid, or may be made of one or more selected from hypromellose, hyaluronic acid, and cellulose gum, but is not limited thereto.

The biodegradable adhesive material used in the adhesive portion 100 completely dissolves itself by saliva in the oral cavity over a period of time approximately 6 hours to 10 hours after attachment, and thus, any one of the oral mucosa 20, gums, or teeth It can reduce the hassle that users have to detach separately after attaching to.

The non-adhesive portion 200 is formed on one surface 130 of the adhesive portion 100.

The non-adhesive portion 200 is solid at room temperature and may be formed of vegetable fat that melts as a liquid at oral temperature.

The vegetable fat used in the present invention includes saturated fatty acids, and thus palm oil and cocoa butter having a melting point of 30 to 37 degrees may be used.

In the embodiment of the present invention, palm oil (palm oil) and cocoa butter (cocoa butter) are described, but in addition, vegetable fats having a melting point of 30 to 37 degrees, which are commonly known in the art, may be used. butter), pistachio butter (pistachio) may be used.

The vegetable fat used in the present invention contains saturated fatty acids, and thus has a high melting point. Since it exists in a solid form at room temperature and must be dissolved as a liquid at oral temperature, vegetable fat having a melting point of 30 to 37 degrees may be used.

Table 1 is the melting point of the vegetable fat used in the present invention.

Kinds Melting point (℃) Palm oil 31 to 38 Cocoa butter 30 to 36

The non-adhesive portion 200 of the oral patch 1000 according to an embodiment of the present invention is formed as a vegetable fat that exists as a solid at room temperature and melts at the oral temperature, so that it is in any one of the oral mucosa 10, gums, or teeth. Before adhesion, it is formed as a solid on one side 130 of the adhesion part 100, and may be melted after adhesion to the oral mucosa 10 or teeth in the oral cavity.

At this time, the oral patch 1000 according to an embodiment of the present invention is adhered to any one of the oral mucosa 10, gums or teeth, the non-adhesive portion 200 is quickly melted at the oral temperature, and the adhesive portion 100 ) Is slowly dissolved by saliva in the oral cavity, the non-adhesive portion 200 may not prevent the active material 110 from being released in the direction of one side 130 of the adhesive portion 100.

The non-adhesive portion 200 may be formed in a thin film form of vegetable fat on one side 130 of the adhesive portion 100 in order to be quickly melted after being adhered to any one of the oral mucosa 10, gums or teeth. . In addition, referring to FIG. 4, the non-adhesive portion 200 may be formed by scattering on the surface of the adhesive portion 100 in a powder form.

As described above, the non-adhesive portion 200 of the oral patch 1000 according to the present invention exists in a solid form before the user attaches the oral patch 1000 to the oral mucosa 10 or teeth, so that the active substance 110 is It can be prevented from being discharged out of the oral patch 1000, and by being melted after attachment, the active material 100 may not be prevented from being released into the oral cavity.

Referring to FIG. 5, the oral patch 1000 according to the present invention is adhered to the oral mucosa 10, and then the non-adhesive portion 200 is immediately melted so that the active substance 110 can be released into the oral cavity.

That is, the oral patch 1000 according to the present invention is a zinc compound contained in the adhesive portion 100 as the adhesive portion 100 is gradually dissolved by saliva in the oral cavity after the non-adhesive portion 200 is melted in the oral cavity. Also, active substances such as vitamins are continuously released into the oral cavity for a long period of time and consumed together with saliva to prevent or treat oral diseases.

In particular, the oral patch 1000 according to the present invention does not absorb the active substance for prevention or treatment of oral diseases through the oral mucosa 20, but is released into the oral cavity and must be continuously consumed with saliva for a long period of time, It is effective in preventing or treating oral diseases such as dry mouth.

6 is a schematic cross-sectional view of an oral patch for another embodiment of the present invention.

Referring to FIG. 6, as another embodiment of the present invention, the oral patch 1000 of the present invention may further include a peeling part 300 on the other surface of the adhesive part 100.

By forming the peeling part 300 on the other surface of the adhesive part 100, the oral patch 1000 can be protected from external substances before attaching the oral patch 1000 to any one of the oral mucosa, gums or teeth. .

The peeling part 300 may be formed in a film form by using a polymer that is water-insoluble and water-impermeable.

The peeling part 300 may be formed in a transparent or translucent form so that it does not dissolve by moisture, hardly passes through moisture, and does not visually have a feeling of rejection.

The polymer usable as the peeling part 300 is polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacrylic acid copolymer, for example, methacryloyl ethyl betaine / methacrylate copolymer (yukaformer), meta Acrylic copolymer, aminoalkyl methacrylate copolymer (Eudragit E, RL), cellulose acetate phthalate, polyethylene, PVC, polyurethane alone or mixtures thereof.

Hereinafter, the present invention will be described in more detail through Examples and Test Examples, but the scope of the present invention is not necessarily limited to these examples.

Example  1, 2 and Comparative example  1, 2

Oral patches of Examples 1 and 2 and Comparative Examples 1 and 2 were prepared with the composition shown in Table 2 below.

<Production Method of Example>

(1) After adjusting the thickness using an applicator with the composition of the adhesive portion as shown in Table 2, sol coating, and dried at 0 to 70 degrees for 3 to 24 hours.

(2) After applying the composition of the non-adhesive portion as shown in Table 2 on the adhesive portion, it was quickly dried at 10 degrees or less. The thickness of the adhesive portion was prepared to be 300 to 500 μm, and the thickness of the non-adhesive portion was 10 μm.

<Production Method of Comparative Example 1>

(1) After adjusting the thickness using an applicator with the composition of the adhesive portion as shown in Table 2, sol-coated, and dried at 0 to 70 degrees for 3 to 24 hours.

(2) The non-adhesive composition composition solution as described in Table 2 was applied on the adhesive and dried. The thickness of the adhesive portion was prepared to be 300 to 500 μm, and the thickness of the non-adhesive portion was 10 μm.

<Production Method of Comparative Example 2>

In Comparative Example 2, there was no non-adhesive part in Example 2, and it was prepared as in Example Production Method (1).

division Raw material name Example 1 Example 2 Comparative Example 1 Comparative Example 2 Gradually Hydroxypropylcellulose 3 Hydroxyethyl cellulose 3 3 glycerin 8 8 10 8 Zinc gluconate 1.5 1.5 1.5 1.5 Polyvinyl pyrrolidone 22 Hydrogen peroxide 5 glycerin 10 ethanol 30 Purified water 87.5 87.5 21.5 87.5 Non-adhesive palm oil 100 cocoa 100 Sorbitol 8 Polyethylene glycol 3 Hydroxypropylcellulose 10 Purified water 79

[Effect Test Example 1] Evaluation of adhesion

In order to measure adhesion evaluation, 40 subjects were tested per experimental group. It was evaluated on a 10-point scale, and 10 attempts were made for each experimental group.

Example 1 Example 2 Comparative Example 1 Comparative Example 2 Ease of attachment 9.5 9.1 5.1 7.2

[Effect Test Example 2] Evaluation of zinc concentration measurement in the oral cavity

7 is a graph showing the results of measuring zinc concentration in the oral cavity after using Examples 1 and 2 and Comparative Examples 1 and 2.

To evaluate the zinc concentration in the oral cavity, 2 mL of non-stimulated saliva in the oral cavity was collected using the passive drool collection method, and filtered through a syringe filter to extract 1 mL of saliva with a low viscosity. This sample is injected into ion chromatography (IC) to measure the concentration of zinc ions (Zn ²⁺ ) in the oral cavity. Before applying each oral patch, 30 minutes after application, and 1 hour later, saliva is extracted respectively to measure the concentration of zinc.

Referring to FIG. 7, zinc concentration in the oral cavity according to time for Examples 1 and 2 and Comparative Examples 1 and 2. The x-axis is time and the y-axis is the concentration of zinc in the oral cavity.

Over time, Examples 1, 2, and Comparative Example 2 can be seen that the zinc concentration in the oral cavity is increasing, and Comparative Example 1 can be seen that the change in zinc concentration in the oral cavity is small. That is, Examples 1 and 2 including the non-adhesive portion had almost the same zinc concentration in the oral cavity as Comparative Example 2 without the non-adhesive portion. It can be seen that it dissolves and disappears soon after sticking. On the other hand, in Comparative Example 1 containing the non-adhesive portion, the concentration change in the oral cavity was small as time passed, so that the non-adhesive portion of Comparative Example 1 was maintained continuously without dissolving after the oral patch adhered to the oral cavity. Able to know.

[Effect Test Example 3] Evaluation of bad breath concentration in the oral cavity

8 is a graph showing the results of measurement of bad breath concentration in the oral cavity after using Examples 1 and 2 and Comparative Examples 1 and 2 and Listerin and Gaglin. Here, Listerine used Johnson & Johnson's Listerine mouthwash, and Gaglin used Donga Pharmaceutical's Gagreen Zero.

The bad breath concentration in the oral cavity was measured with a twin brusher. After measuring the halitosis concentration at 0 minutes, the oral patch was applied to the oral mucosa, and then the halitosis concentration at 10 minutes, 15 minutes, 30 minutes, and 1 hour after each was measured.

Referring to Figure 8, Examples 1, 2, Comparative Examples 1 and 2 and the list of oral odor concentrations over time for Listerine and Gaglin. The x-axis is time and the y-axis is the bad breath concentration in the oral cavity.

Over time, Examples 1, 2, and Comparative Example 2 can be seen that the oral bad breath concentration is decreasing, Comparative Example 1 can be seen that the change in oral bad breath concentration is insufficient, Listerine and gargling It can be seen that the bad breath concentration in the oral cavity decreases until 10 minutes after use, and the bad breath in the oral cavity increases again after 10 minutes.

That is, in Examples 1 and 2 containing the non-adhesive portion, the oral odor concentration of the non-adhesive portion of Examples 1 and 2 was decreased in that the oral odor concentration in Examples 1 and 2 was almost the same as in Comparative Example 2 without the non-adhesive portion. It can be seen that it dissolves and disappears soon after being adhered to. And, it can be seen that the bad breath is reduced by increasing the zinc concentration in the oral cavity.

On the other hand, in Comparative Example 1 including the non-adhesive portion, the change in bad breath concentration in the oral cavity over time was insignificant, and the non-adhesive portion of Comparative Example 1 was maintained continuously without dissolving after the oral patch adhered to the oral cavity. You can see that In addition, the listerine and gargling have an effect of bad breath in the oral cavity within 10 minutes after use, but it can be seen that the bad breath in the oral cavity increases after 10 minutes, and thus there is no effect of continuous bad breath removal.

As described above, in the oral patch according to the embodiment of the present invention, zinc, which is an effective substance for preventing or treating oral diseases, is not absorbed through the oral mucosa, but is released into the oral cavity and continuously ingested with saliva to prevent bad breath or Effective for treatment.

The present invention described above is not limited to the above-described embodiments and the accompanying drawings, and various substitutions, modifications and changes are possible within the scope of the present invention without departing from the technical spirit of the present invention. It will be apparent to those of ordinary skill.

100: adhesive portion 110: active material
130: one side of the adhesive portion 150: the other side of the adhesive portion
200: non-adhesive part 300: peeling part
1000: oral patch 10: oral mucosa

Claims (11)

An adhesive portion formed of a water-soluble hydrocolloid preparation; And
Located on one side of the adhesive portion, the oral patch comprising a non-adhesive portion formed as a vegetable fat that exists as a solid at room temperature and melts at the oral temperature. According to claim 1,
The vegetable fat is an oral patch, characterized in that palm oil (palm oil) or cocoa butter (cocoa butter). According to claim 1,
Oral patch, characterized in that the melting point of the vegetable fat is 30 to 37 degrees. According to claim 1,
The vegetable fat oral patch, characterized in that it contains a saturated fatty acid. According to claim 1,
Oral patch characterized in that the adhesive portion further comprises an active material. The method of claim 5,
The active substance is a zinc compound, vitamins, natural extracts, antifungal agents, anti-inflammatory agents, anesthetics, oral patch comprising at least one of an antibacterial agent. The method of claim 5,
The active material is an oral patch characterized in that the non-adhesive portion is dissolved in the oral cavity, and then released into the oral cavity in one direction of the adhesive portion. According to claim 1,
The oral cavity patch characterized in that the other side of the adhesive portion is dissolved by oral saliva and adheres to any one of the oral mucosa, gums or teeth. According to claim 1,
Oral patch characterized in that the non-adhesive portion melts faster than the adhesive portion in the oral cavity. According to claim 1,
Oral patch characterized in that it further comprises a peeling portion located on the other surface of the adhesive portion. The method of claim 10,
The peeling portion is detached from the adhesive portion, the oral patch characterized in that it is formed of a water-insoluble (water-insoluble) and water-impermeable polymer.

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