KR20210012215A - A patch for oral cavity - Google Patents

Abstract

An oral patch according to the present invention comprises: a body part having an adhesive surface and a release surface facing each other, and comprising an active material; a non-adhesive part located on the release surface, and formed of vegetable fat which exists as a solid at room temperature and melts at oral temperature; and a microstructure positioned on the adhesive surface. The present invention can easily adhere the oral patch.

Description

Oral Patch {A PATCH FOR ORAL CAVITY}

The present invention relates to an oral patch containing an effective substance capable of preventing or treating oral diseases while being adhered to the oral cavity.

Oral diseases are on the rise due to the westernization of dietary habits, and along with the increase of the elderly population in Korea, medical expenses for gum disease, a representative elderly oral disease, are on the rise.

Individual and social burdens are increased according to oral diseases, and two oral-related injuries are included in the ranking of the domestic outpatient frequent injuries, and the 1st place is dental and periodontal disease, and the 12th place is dental caries. Appeared as (caries).

In spite of the increasing importance of early prevention and treatment of oral diseases, there is currently no satisfactory prevention or treatment for gum disease and dry mouth.

Products on the market do not have the ability to control biofilms present in the oral cavity, which causes oral diseases, so it is difficult to expect fundamental preventive and therapeutic effects.

For example, products marketed in relation to gum disease are steroid-like ingredients that only temporarily reduce inflammation, and products for preventing dental caries (caries) include xylitol gum, fluoride-enhanced toothpaste, and gargle. It does not have a preventive effect.

Recently, a patch for oral mucosa that can be directly attached to the oral cavity has been introduced. These patches are formed of a fibrous support that is hydrophobic on one side and hydrophilic on the other side, preventing the penetration of saliva and the release of drugs into the oral cavity through the hydrophobic side, and directing drugs for the prevention or treatment of oral diseases to the mucous membrane. It is a way to absorb it. However, these patches are not suitable for the purpose of preventing or treating oral diseases such as removal of bad breath, which should act by releasing an effective substance into the oral cavity because the drug is absorbed into the mucous membrane and exerts physiological functions.

Accordingly, the present inventors have a long-term effect in the prevention or treatment of oral diseases, and even if an effective substance for preventing or treating oral diseases is not directly absorbed into the mucous membrane, an effective substance for preventing or treating oral diseases is ingested, and by saliva An oral patch that is completely dissolved and does not need to be detached was developed.

Korean Patent Publication No. 10-2016-0108703 (Publication, 2016.09.20.)

It is an object of the present invention to provide an oral patch capable of releasing into the oral cavity an effective substance capable of preventing or treating oral diseases continuously for a long time while adhering to the oral cavity.

In order to solve this problem, the oral patch according to an embodiment of the present invention includes a body portion having an adhesive surface and a release surface facing each other, and including an active material; A non-adhesive portion located on the release surface and formed of vegetable fat that is solid at room temperature and melts at oral temperature; And a microstructure positioned on the adhesive surface.

The microstructure may include a pillar portion protruding upward and a suction portion in the form of a sucker formed on the pillar portion.

The microstructure may include a suction part in the form of an intaglio sucker.

It further includes a base portion positioned on the adhesive surface, and the microstructure may be positioned on the base portion.

The base portion and the microstructure may be integrally formed.

The non-adhesive portion may be the vegetable fat is palm oil or cocoa butter.

The vegetable fat may have a melting point of 30 to 37 degrees.

The vegetable fat may contain saturated fatty acids.

The body portion may be made of a water-soluble material that is dissolved by contact with saliva or tongue in the oral cavity.

The water-soluble material may be made of any one of a hydrocolloid formulation, a hydrogel formulation, and a cellulose derivative.

The active substance may be released in the direction of the release surface after the non-adhesive part is dissolved in the oral cavity.

According to the present invention as described above has the following effects.

In the present invention, as the oral patch is dissolved by saliva in the oral cavity, effective substances such as zinc compounds and vitamins are continuously released into the oral cavity for a long period of time, so that it is ingested with saliva to prevent or treat oral diseases.

In the present invention, since the body part and the non-adhesive part are formed to have different colors to be distinguished, the adhesive surface can be easily recognized when the user adheres the oral patch to the oral cavity, so that the oral patch can be easily adhered.

In the present invention, by forming a non-adhesive portion that is removed from the oral cavity earlier than the body portion on the release surface, it is possible to prevent the active substance contained in the body portion from being released to the outside before the user uses the oral patch. After adhering to the oral mucosa, the non-adhesive portion is immediately dissolved and the active substance can be released into the oral cavity.

The oral patch according to the present invention is composed of substances in which the mucous membrane is dissolved by saliva in the oral cavity, so it is completely dissolved by itself after being attached to the oral mucosa or teeth, so that the user does not need to separate and remove the hassle of detachment. I can.

When the oral patch 1000 according to an embodiment of the present invention is adhered to the oral mucosa or teeth, the adsorption unit prevents the outflow of air and induces a difference between the pressure inside the sucker and the pressure outside the sucker, so that it adheres well to the oral mucosa or teeth. Can be.

In addition, other features and advantages of the present invention may be newly recognized through embodiments of the present invention.

1 is a schematic cross-sectional view of an oral patch according to an embodiment of the present invention.
FIG. 2 is a cross-sectional view taken along line A-A' of the oral patch shown in FIG. 1.
3 is a view schematically showing a suction part in the form of various suckers of the oral patch according to an embodiment of the present invention.
4 is a schematic cross-sectional view of an oral patch according to another embodiment of the present invention.
5 is a cross-sectional view taken along line B-B' of the oral patch shown in FIG. 4.
6 is a schematic cross-sectional view of an oral patch according to another embodiment of the present invention.
7 is a schematic cross-sectional view of an oral patch according to another embodiment of the present invention.
8 is a view showing an example of attaching the oral patch according to the present invention to the upper jaw oral mucosa.
9 is a view showing an exemplary state in which the effective material of the oral patch according to the present invention is released into the oral cavity.
10 is a graph showing the results of measuring zinc concentration in the oral cavity after using Examples 1 and 2 and Comparative Examples 1 and 2. FIG.

In the present specification, in adding reference numerals to elements of each drawing, it should be noted that only the same elements have the same number as possible, even if they are indicated on different drawings.

Meanwhile, the meaning of terms described in the present specification should be understood as follows.

It is to be understood that terms such as "comprise" or "have" do not preclude the presence or addition of one or more other features or numbers, steps, actions, components, parts, or combinations thereof.

The term "on" is meant to include not only a case where a certain structure is formed directly on the upper surface of another structure, but also a case where a third structure is interposed between these elements.

The term "patch" refers to an adhesive formulation containing a specific component, and the shape or structure of the patch is not particularly limited.

Hereinafter, preferred embodiments of the present invention designed to solve the above problem will be described in detail with reference to the accompanying drawings.

1 is a schematic cross-sectional view of an oral patch according to an embodiment of the present invention, FIG. 2 is a cross-sectional view taken along line A-A' of the oral patch shown in FIG. 1, and FIG. 3 is an embodiment of the present invention. It is a view schematically showing the adsorption unit in the form of various suckers of the oral patch according to the.

1 and 2, the oral patch 1000 according to an embodiment of the present invention includes a body part 100, a non-adhesive part 200 located on one surface of the body part 100, and a body part 100. ) And a plurality of microstructures 300 positioned on the other surface.

The body part 100 includes an effective material 110 for preventing or treating oral diseases.

In one embodiment, the effective substance 110 may be made of any one of a zinc compound, a vitamin, and a natural extract having antibacterial and anti-biofilm activity against oral pathogens, but is not limited thereto, and prevention and treatment of oral diseases It does not specifically limit if it is a substance for the purpose.

For example, zinc compounds include zinc chloride, zinc sulfate, zinc gluconate, zinc acetate, zinc citrate, zinc chelating, zinc salicylate, zinc nitrate, zinc oxide, zinc stearate, zinc carbonate. (zinc carbonate), zinc oleate, zinc fluoride, zinc acetate, zinc formate, zinc lactate, zinc ammonium sulfate ammonium sulfate), zinc nitrate, zinc sulfonate, zinc chloride, zinc sulfate, zinc citrate, zinc glycerophosphate , Zinc tartarate, or a zinc complex thereof may be included.

Zinc reacts with volatile sulfides (VSC) to form insoluble, odorless zinc sulfide, and can reduce the number of microbes in the oral cavity through antibacterial action, and thiol group (-SH), a precursor of volatile sulfides (VSC). ) By suppressing the production, it is effective in preventing bad breath and removing bad breath. In addition, zinc plays an essential role in the differentiation and proliferation of cells, plays an important role in growth, tissue and skeletal formation, reproduction, and immune functions, and can delay skin aging due to the sulfation of zinc.

At this time, when the effective material of the oral patch 1000 according to the present invention is a zinc compound, the zinc compound is preferably formed by including 1 mg or more and 30 mg or less of zinc.

If less than 1 mg of zinc is formed among zinc compounds, the effect of preventing bad breath and removing bad breath may decrease, and if it exceeds 30 mg, it may cause side effects due to excessive intake of zinc.

In one embodiment, when the active substance 110 is a vitamin, it may be vitamin B12 or vitamin A.

Vitamin B12 is a water-soluble vitamin called cobalamin. It is an essential component for red blood cell production, nerve function, and DNA synthesis. It acts as a cofactor in the synthesis of methionine and L-methylmalonyl-CoA mutase. do. It is also an ingredient necessary for the maintenance of myelin (myelin) for nerve function.

In particular, when vitamin B12 is deficient, symptoms of neurological disorders such as tingling, numbness, movement disorders, and cognitive impairment at the ends of the body may appear.

In addition, vitamin A is an effective substance for treating periodontitis.

In one embodiment, if the active substance 110 is a natural extract, woobangja, brown flower, designation of magnetization, motherwort, red bean flower, chow, motherwort, Astragalus, ginseng, anemarrhena, gardenia, golden cherry, branch , Goryanggang, Overbody, Hwapi, Blue Box, Cheonnyeonja, Johyup, Balsam, Golden/Mokdanpi, Sukiyaki, Licorice, Clove, Eggplant Stalk, White Paper, Gojija, Pine Needle, Butterfly Flower, Menthol, EM, Sapindus mukurossi Gaerth , Plum, pork potato, Ecklonia cava, amaranth, cassava, purslane, parsley, chives, fermented herbs, may be a natural extract isolated from any one of 　　.

The body part 100 may have an adhesive surface 150 and a discharge surface 130 facing each other.

The release surface 130 is a place where the effective material 110 is discharged to one surface of the body part 100, and the adhesion surface 150 is a place where a plurality of microstructures 300 adhered to the mucous membrane or teeth in the oral cavity are located to be.

The body part 100 may be made of a biodegradable adhesive material that is gradually completely dissolved by contact with saliva or tongue in the oral cavity.

The biodegradable adhesive material included in the body part 100 forms a gel or a viscous solution in an aqueous system. As the biodegradable adhesive material, a variety of known adhesive materials may be used as a material that increases adhesion to the surface, and in particular, a biodegradable water-soluble polymer that can be degraded in a living body including cells or tissues may be used.

Examples of such a material may be made of at least one selected from a water-soluble hydrocolloid formulation, a hydrogel formulation, and a water-soluble cellulose derivative, but is not limited thereto, and any biodegradable adhesive material may be used.

For example, the water-soluble cellulose derivative is, for example, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, carboxymethylcellulose, or a polymethacrylic acid-based polymer such as polyethylene glycol (PEG), polymethacrylic acid, poly -2-hydroxyethyl methacrylic acid, or hypromellose, hyaluronic acid, may be made of at least one selected from cellulose gum, but is not limited thereto.

The biodegradable adhesive material used for the body part 100 is completely dissolved by the saliva in the oral cavity after a certain period of time, approximately 6 to 10 hours after being attached, so that the user can separate it after being attached to the oral mucosa or teeth. You can reduce the hassle of detaching.

The non-adhesive portion 200 is formed on the emission surface 130 of the body portion 100.

The non-adhesive portion 200 may be formed of vegetable fat that is solid at room temperature and soluble in liquid at oral temperature.

More specifically, the non-adhesive portion 200 of the oral patch 1000 according to an embodiment of the present invention is the release surface of the adhesive portion 100 before being adhered to the oral mucosa 10, teeth 20, or gums ( 130), and after being adhered to the oral mucosa 10, teeth 20, or gums in the oral cavity, it may be melted into a liquid at the oral temperature.

That is, the non-adhesive portion 200 is removed from the oral cavity before the adhesive portion 200 after being adhered to the oral mucosa 10, the teeth 20, or the gums, so that the effective material 113 and the buffer 115 It may not interfere with the discharge in the direction of the discharge surface 130 of the adhesive part 100.

The non-adhesive portion 200 may be formed of vegetable fat that is solid at room temperature and melts into a liquid at oral temperature.

Since the vegetable fat used in the present invention contains saturated fatty acids, palm oil and cocoa butter having a melting point of 30 to 37 degrees may be used.

In the embodiment of the present invention, the description is limited to palm oil and cocoa butter, but any vegetable fat having a melting point of 30 to 37 degrees commonly known in the art may be used. For example, shea (shea) butter), pistachio butter can be used.

The vegetable fat used in the present invention contains saturated fatty acids and has a high melting point. Since it exists in a solid form at room temperature and must melt into a liquid at oral temperature, vegetable fats having a melting point of 30 to 37 degrees can be used.

Table 1 is the melting point (melting point) of vegetable fat used in the present invention.

Kinds Melting point(℃) Palm oil 31 to 38 Cocoa butter 30 to 36

The non-adhesive portion 200 of the oral patch 1000 according to the embodiment of the present invention is formed of vegetable fat that exists as a solid at room temperature and melts at the oral temperature, so that the oral mucosa 10, the tooth 20, or the gum It is formed as a solid on the release surface 130 of the adhesive portion 100 before being adhered to, and may be melted after being adhered to the oral mucosa 10 or teeth in the oral cavity.

At this time, the oral patch 1000 according to the embodiment of the present invention is adhered to the oral mucosa 10, teeth 20, or gums, and then the non-adhesive portion 200 quickly melts at the oral temperature, and the adhesive portion ( Since 100) is gradually dissolved by saliva in the oral cavity, the non-adhesive portion 200 may not prevent the effective substance 110 from being released toward the one surface 130 of the adhesive portion 100.

This non-adhesive portion 200 is formed in the form of a thin film of vegetable fat on the release surface 130 of the adhesive portion 100 in order to quickly melt after being adhered to the oral mucosa 10, teeth 20, or gums. , The non-adhesive portion 200 may be formed by scattering on the surface of the adhesive portion 100 in a powder form.

In this way, the non-adhesive portion 200 of the oral patch 1000 according to the present invention exists in a solid form before the user attaches the oral patch 1000 to the oral mucosa 10, teeth 20, or gums. The effective material 110 may be prevented from being released out of the oral patch 1000, and after attachment, it may be melted so as not to prevent the effective material 100 from being released into the oral cavity.

A plurality of microstructures 300 spaced apart from each other are formed on the adhesive surface 150 of the body part 200.

Referring to FIG. 3, the microstructure 300 includes a pillar portion 310 protruding above the adhesive surface 150 and a suction portion 330 in the form of a sucker formed on the pillar portion 310.

The pillar portion 310 is formed to protrude above the adhesive surface 150 in a cylindrical shape.

The adsorption part 330 has a shape like a sucker of an octopus and has a hollow cavity, a crater shape like (a), a concave shape like (b), and a concave shape like (c). It can be formed in various shapes, such as a shape formed by protruding in a hemispherical shape in the entered space, and a shape entering into a square as shown in (d).

The adsorption unit 330 is designed from the tentacles of cephalopods such as octopuses, and may have a structure and shape similar to a sucker disposed on the tentacles of cephalopods.

When the oral patch 1000 according to an embodiment of the present invention is adhered to the oral mucosa or teeth, the adsorption unit 330 prevents the outflow of air and induces a difference between the pressure in the sucker and the pressure other than the sucker, thereby improving adhesion. I can make it.

This adhesive force may be due to a van der Waals force between the adherend and the adsorption part, or a suction force due to a pressure difference inside and outside the sucker due to a change in the shape of the sucker after adhesion.

As an embodiment, the microstructure 300 may be formed of the same material in the same process as the body part 200. That is, the body portion 200 and the microstructure 300 may be integrally formed.

In another embodiment, the microstructure 300 may be formed of the same material as the body part 200, but may have different viscosity by adjusting the amount of the curing agent. That is, since the viscosity of the microstructure 300 is formed larger than the viscosity of the body portion 200, the microstructure 300 may be dissolved after the body portion 200 is completely dissolved in the oral cavity.

4 is a schematic cross-sectional view of an oral patch according to another embodiment of the present invention, and FIG. 5 is a cross-sectional view taken along line B-B' of the oral patch shown in FIG. 4, wherein the structure of the microstructure 300 is changed. Except that, it is the same as the oral patch according to FIGS. 1 to 3 described above. Accordingly, the same reference numerals are assigned to the same configuration, and repeated descriptions of the same configuration will be omitted.

4 and 5, an oral patch 1000 according to another embodiment of the present invention includes an intaglio microstructure 300.

The engraved microstructure 300 may be formed in the form of an engraved sucker on the adhesive surface 150 of the body portion 200.

The shape of the intaglio sucker may be formed in various shapes of the above-described suction unit.

Unlike the embossed microstructure, the engraved microstructure 300 does not have a pillar, and in addition to the engraved sucker-shaped adsorption unit, the adhesive surface 150 of the body 200 is directly adhered to the adherend, thereby increasing adhesion. It can be improved.

6 is a schematic cross-sectional view of an oral patch according to another embodiment of the present invention, and is the same as the oral patch according to FIGS. 1 to 3 except that a base portion 400 is added. Accordingly, the same reference numerals are assigned to the same configuration, and repeated descriptions of the same configuration will be omitted.

6, an oral patch 1000 according to another embodiment of the present invention includes a body portion 100, a non-adhesive portion 200 positioned on one surface of the body portion 100, and the other surface of the body portion 100. It includes a base part 400 located at and a plurality of microstructures 300 located on the base part 400.

At this time, one surface of the body portion 100 is an emission surface, and the other surface of the body portion 100 is an adhesive surface.

In one embodiment, the plurality of microstructures 300 are embossed microstructures including a column part protruding upward on the base part 400 and a suction part in the form of a sucker formed on the column part as described above in FIGS. 1 to 3. It can be formed into a structure.

Although not shown, in another embodiment, the plurality of microstructures 300 may be formed as intaglio microstructures on the base portion 400 as described above with reference to FIGS. 4 and 5.

In this case, the base portion 400 and the plurality of microstructures 300 may be formed of the same material in the same process. That is, the base portion 400 and the microstructure 300 may be integrally formed.

In addition, the body portion 200 and the base portion 400 are also formed of the same material, but may have different viscosity by adjusting the amount of the curing agent. That is, the viscosity of the base portion 400 and the microstructure 400 is formed to be greater than the viscosity of the body portion 200, so that after the body portion 200 is completely dissolved in the oral cavity, the base portion 400 and the microstructure 300 Can be dissolved.

7 is a schematic cross-sectional view of an oral patch according to another embodiment of the present invention, and is the same as the oral patch according to FIGS. 1 to 3 except that the structure of the microstructure 300 is changed. Accordingly, the same reference numerals are assigned to the same configuration, and repeated descriptions of the same configuration will be omitted.

Referring to FIG. 7, an oral patch 1000 according to another embodiment of the present invention includes a single microstructure 300.

In one embodiment, although the figure shows a microstructure 300 having an intaglio on the other surface of the body part, it is not limited thereto, and may be formed including a column part protruding upward and a suction part in the form of a sucker formed on the column part.

In addition, the shape of the microstructure 300 may be formed in various sucker shapes shown in FIG. 3.

FIG. 8 is a view exemplarily showing a state in which the oral patch according to the present invention is attached to the upper jaw oral mucosa, and FIG. 9 is a view exemplarily illustrating a state in which the active substance of the oral patch according to the present invention is released into the oral cavity .

8 and 9, when the microstructure of the oral patch 100 is pressed toward the oral mucosa 10 or the tooth 20 for 2 to 3 seconds, the adsorption of the microstructure is applied to the oral mucosa 10 or the teeth. Can be adhered to (20).

After the oral patch 1000 according to the present invention is adhered to the oral mucosa 10, the non-adhesive portion is immediately dissolved so that the effective material 110 can be released into the oral cavity through the release surface.

As described above, the oral patch 1000 according to the present invention is dissolved by saliva in the oral cavity, and effective substances such as zinc compounds and vitamins are continuously released into the oral cavity for a long period of time, so that it is ingested with saliva to prevent or treat oral diseases. have.

In particular, in the oral patch 1000 according to the present invention, an effective substance for the prevention or treatment of oral diseases is not absorbed through the oral mucosa 20, but is released into the oral cavity, and is continuously ingested with acupuncture for a long period of time. It is effective in preventing or treating oral diseases such as dryness.

Hereinafter, the present invention will be described in more detail through examples and test examples, but the scope of the present invention is not necessarily limited to these examples.

Example 1, 2 and Comparative example 1, 2

Oral patches of Examples 1 and 2 and Comparative Examples 1 and 2 were prepared with the compositions shown in Table 2.

<Preparation method of Example>

(1) After adjusting the thickness using an applicator to the composition of the adhesive portion as shown in Table 2, forming a microstructure, sol coating, and dried at 0 to 70 degrees for 3 hours to 24 hours.

(2) After applying the composition of the non-adhesive portion as described in Table 2 on the adhesive portion, it was quickly dried at 10 degrees or less. The thickness of the adhesive portion was manufactured to be 300 to 500 μm, and the thickness of the non-adhesive portion was manufactured to be 10 μm.

<Production method of Comparative Example 1>

(1) After adjusting the thickness using an applicator to the composition of the adhesive portion as shown in Table 2, sol-coated, and dried at 0 to 70 degrees for 3 hours to 24 hours.

(2) The non-adhesive portion composition solution as described in Table 2 was applied on the adhesive portion and then dried. The thickness of the adhesive portion was manufactured to be 300 to 500 μm, and the thickness of the non-adhesive portion was manufactured to be 10 μm.

<Production method of Comparative Example 2>

Comparative Example 2 was prepared in the same manner as in Example 2 without a buffer and a non-adhesive part, and was prepared in the same manner as in Example (1).

division Raw material name Example 1 Example 2 Comparative Example 1 Comparative Example 2 Adhesive Hydroxypropyl cellulose 3 Hydroxyethyl cellulose 3 3 glycerin 8 8 10 8 Na ₂ HPO ₄ 0.2 NaH ₂ PO ₄ 0.1 K ₂ HPO ₄ 0.2 KH ₂ PO ₄ 0.1 Zinc gluconate 1.5 1.5 1.5 Polyvinyl pyrrolidone 22 Hydrogen peroxide 5 glycerin 10 ethanol 30 Purified water 88.7 87.2 21.5 87.5 Non-adhesive part palm oil 100 cocoa 100 Sorbitol 8 Polyethylene glycol 3 Hydroxypropyl cellulose 10 Purified water 79

[Effect Test Example 1] Evaluation of adhesion

In order to measure the adhesion evaluation, a test was performed on 40 ordinary people per experimental group. It was evaluated on a 10-point scale, and 10 attempts were made for each experimental group, and if it was attached and lasted for more than 6 hours, it was a perfect score, and if it was attached 1 hour less than 6 hours, it was deducted by 2 points.

Example 1 Example 2 Comparative Example 1 Comparative Example 2 Adherence 9.7 9.5 4.2 5.6

[Effect test example 2] Oral zinc concentration measurement evaluation

10 is a graph showing the results of measuring zinc concentration in the oral cavity after using Examples 1 and 2 and Comparative Examples 1 and 2. FIG.

To evaluate the zinc concentration in the oral cavity, 2 mL of non-irritating saliva in the oral cavity is collected using the passive drool collection method, filtered through a syringe filter, and 1 mL of low-viscosity saliva is extracted. This sample is injected into ion chromatography (IC) to measure the concentration of zinc ions (Zn ²⁺ ) in the oral cavity. Saliva is extracted before applying each oral patch, 30 minutes after applying, and 1 hour after applying, and the concentration of zinc is measured.

Referring to FIG. 10, the concentration of zinc in the oral cavity over time for Examples 1 and 2 and Comparative Examples 1 and 2. The x-axis is time and the y-axis is the oral zinc concentration.

It can be seen that the zinc concentration in the oral cavity is increasing in Example 2 and Comparative Example 2 over time, and it can be seen that there is no change in the zinc concentration in the oral cavity in Example 1 and Comparative Example 1. That is, since Example 2 including the non-adhesive part had almost the same change in oral zinc concentration as Comparative Example 2 that did not contain the non-adhesive part, the non-adhesive part of Example 2 was immediately after the oral patch adhered to the oral cavity. It can be seen that it dissolves and disappears. On the other hand, Comparative Example 1 including the non-adhesive portion was seen that there was no change in the concentration in the oral cavity over time, so that the non-adhesive portion of Comparative Example 1 did not dissolve after the oral patch was adhered to the oral cavity and was maintained continuously. Able to know.

As described above, in the oral patch according to an embodiment of the present invention, zinc and buffer, which are effective substances for the prevention or treatment of oral diseases, are not absorbed through the oral mucosa, but are released into the oral cavity and continuously ingested with acupuncture for a long period of time. It is effective for prevention or treatment.

The present invention described above is not limited to the above-described embodiments and the accompanying drawings, and that various substitutions, modifications and changes are possible within the scope of the technical spirit of the present invention, in the technical field to which the present invention belongs. It will be obvious to those of ordinary skill.

100: body part 110: active substance
130: emitting surface 150: adhesive surface
200: non-adhesive portion 300: microstructure
310: column portion 330: adsorption portion
400: base 1000: oral patch
10: oral mucosa 20: teeth

Claims (12)

A body portion having an adhesive surface and a discharge surface facing each other and including an active material;
A non-adhesive portion located on the release surface and formed of vegetable fat that is solid at room temperature and melts at oral temperature; And
Oral patch comprising a microstructure located on the adhesive surface. The method of claim 1,
The microstructure is an oral patch, characterized in that formed in a single or plural number. The method of claim 1,
The microstructure is an oral patch, characterized in that it comprises a pillar portion protruding upward and a suction portion in the form of a sucker formed on the pillar portion. The method of claim 1,
The microstructure is an oral patch, characterized in that it comprises a suction part in the form of a suction cup. The method of claim 1,
Further comprising a base portion located on the adhesive surface,
The microstructure is an oral patch, characterized in that located on the base. The method of claim 5,
Oral patch, characterized in that the base portion and the microstructure is formed integrally. The method of claim 1,
The non-adhesive part, wherein the vegetable fat is palm oil or cocoa butter. The method of claim 1,
Oral patch, characterized in that the melting point of the vegetable fat is 30 to 37 degrees. The method of claim 1,
The vegetable fat oral patch, characterized in that it contains a saturated fatty acid. The method of claim 1,
The oral patch, characterized in that the body part is made of a water-soluble substance dissolved by contact with saliva or tongue in the oral cavity. The method of claim 10,
The water-soluble material is an oral patch, characterized in that consisting of any one of a hydrocolloid formulation, a hydrogel formulation, and a cellulose derivative. According to claim 1
The active substance is an oral patch, characterized in that after the non-adhesive portion is dissolved in the oral cavity, it is released in the direction of the release surface.

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