KR20070080062A - The stability technology of using the technology of the liposome including botanical extract which is effective for anti-acne and the components of cosmetics including the liposome and the method of manufacturing the components - Google Patents

Abstract

A cosmetic composition stabilizing a plant extract by using liposome technology is provided to maintain the activity of the plant extract without loss or modification and realize enough skin beauty effect by the plant extract due to excellent permeability into skin. The cosmetic composition comprising liposome of lecithin, ceramide, a plant extract, an antioxidizer, solvent, and an emulsification stabilization supplemental agent is characterized in that the plant extract is at least one selected from the group consisting of a mixture extract consisting of Sanguisorba officinalis extract, cinnamon extract and ginger extract, an extract of grapefruit seed, an extract of grapefruit, an extract of Sophora flavescens, an extract of Glycyrrhiza uralensis, and an extract of aloe, wherein content of the plant extract is 0.1-20.0 wt.%, 1.0-10.0 wt.% of the lecithin is contained, 0.1-2.0 wt.% of the ceramide is contained, the antioxidizer is at least one selected from the group consisting of a tocopherol derivative including tocoperyl acetate, an ascorbic acid derivative including ascorbic acid, and a natural antioxidizer such as BHT and an extract of grapefruit seed, of which content is 0.1-5.0 wt.%, the solvent is at least one selected from the group consisting of propylene glycol and butylene glycol, of which the content is 0.1-40.0 wt.%, and the emulsification stabilization supplemental agent is at least one selected from the group consisting of glycerine, xylitol, and a natural polymer compound, of which content is 0.1-20.0 wt.%.

Description

Stabilization technology using liposome technology of plant extracts effective for acne suppression, and a cosmetic composition containing the same and a method for preparing the same {the stability technology of using the technology of the liposome including botanical extract which is effective for anti-acne and the components of cosmetics including the liposome and the method of manufacturing the components.}

Figure 1 shows the bactericidal effect of Grapefruit Seed Extract.

FIG. 2 shows the bactericidal effect of Cucumber extract, Cinnamon extract and Ginger extract mixed against Propionibacterium acnes. (72% after application of 0%, 0.5%, 2% and 5%) result)

3 shows the main part of the High Pressure Homogenizer.

The present invention relates to a stabilization technology using a liposome technique of plant extracts effective for acne suppression, and to a cosmetic composition containing the same and a method for producing the same.

In recent years, interest in functional cosmetics containing a specific bioactive substance for the purpose of acne suppression, etc. has been increasing and many studies have been conducted. The present invention also relates to such functional cosmetics, which contains a plant extract having a function of inhibiting acne on the skin by acting strongly against bactericidal and pathogenic microorganisms such as bacteria, fungi, viruses and the like, by acting sterilization, flesh virus and fungus Cosmetic composition. Plant extract compounded in the cosmetic composition of the present invention inhibits the activity of acne bacteria caused by a variety of causes to exhibit the acne suppression function of the skin.

In order to apply the acne suppression function of the plant extracts to cosmetics has been proposed cosmetics added to the plant extracts cosmetics. However, conventional cosmetics have a problem in that the simple emulsification type or gel type products prepared by simply adding a plant extract to the cosmetic composition have a low penetration rate in the body, thereby limiting the efficacy of the extract.

In order to solve this problem, the bioactive components can be delivered stably without being destroyed, and the liposomes can be contained whether the bioactive components are fat-soluble or water-soluble.

However, in the past, liposomes with ceramides and cholesterol, which are cellular interstitial substances of the stratum corneum, or liposomes with lecithin, have limited stability.

Under such circumstances, the inventors of the present invention have studied intensively to provide a composition of a plant extract-containing cosmetic composition which does not have the above-mentioned problems and has excellent skin penetration ability and can be stably preserved without losing long-term activity. The present invention has been accomplished by discovering that this object can be achieved by dissolving with glycols and then liposomes and adding it to cosmetics.

That is, an object of the present invention is 1.0-10.0% lecithin of the total composition weight, 0.1-2.0% ceramide of the total composition weight, 0.1-5.0% tocopheryl acetate of the total composition weight, 0.1-40.0% of the total composition weight Propylene glycol and 0.1-20.0% of the total weight of the composition of the plant extract, more specifically selected from a mixture of cucumber extract, ginger extract and cinnamon extract, grapefruit seed extract, grapefruit extract, red ginseng extract, licorice extract, aloe extract To provide a plant extract containing cosmetic composition, characterized in that it contains a liposome consisting of one or two or more extracts.

Still another object of the present invention is to provide a method for preparing a cosmetic composition in which plant extract-containing liposomes are evenly dispersed by passing a mixture containing purified water, lecithin, ceramide, propylene glycol, and a plant extract through a high pressure hemogenizer. will be.

Hereinafter, the present invention will be described in more detail.

Since the cosmetic composition provided according to the present invention contains liposome-ized plant extracts, it is very excellent in the transdermal absorption of plant extracts and can be stably stored for a long time without losing the activity of the plant extracts.

In the present invention, a substance for forming a liposome containing a plant extract by contacting the plant extract to be liposomed is used with lecithin, and is used in an amount of 1.0% -10.0% based on the total weight of the composition.

In the present invention, the ceramide used to stabilize the liposomes and increase the liposome content of the water-soluble component is used in an amount of 0.1-2.0% based on the total weight of the composition.

The antioxidant in the present invention is one or two or more mixtures selected from tocopherol derivatives including tocopheryl acetate, ascorbic acid derivatives including ascorbic acid, natural antioxidants including BHT or grapefruit seed extract, Used in amounts of 0.1-5.0%.

In the present invention, propylene glycol or butylene glycol is used to increase the solubility of the plant extract and is used in an amount of 0.1-40.0% based on the total weight of the composition.

The cosmetic composition of the present invention may contain an emulsifying stabilizer to stabilize the plant extract, and for example, a polymer such as glycerin, xyitol, and a natural high molecular compound may be used in an amount of 0.1-20.0% based on the total weight of the composition. .

According to the method of the present invention, first, the lecithin and ceramide are dissolved in propylene glycol at 40 degrees, and then homogenized by adding tocopheryl acetate to make a lecithin solution and dissolving the plant extract with propylene glycol to make a plant extract solution, followed by plant extract. The solution is slowly added to the lecithin solution, homogenized with a homomixer, and then slowly added to the aqueous solution to obtain an emulsion. The obtained emulsion is passed through a high pressure homogenizer to obtain an emulsion in which the plant extract-containing liposome is evenly dispersed.

By the method of the present invention as described above, the plant extract that has been used in the conventional cosmetics is more stable and can be sufficiently exhibited the acne suppression function of the plant extract by blending the cosmetics without loss of activity and improving the permeability when applied to the skin. It has become possible to provide cosmetics of the liposome type.

Hereinafter, the present invention will be described in more detail with reference to the following Examples, but the present invention is not limited to these Examples.

Table 1. Example 1 and Comparative Example 1

Manufacturing method

Example 1 Raw materials 1,2,11 and 12 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 3 is dissolved in the raw material 4 to be referred to as grapefruit seed extract solution. The raw materials 7 and 8 are dissolved in the raw material 9 at 40 degrees, cooled to 25-30 degrees, and then the raw material 10 is added and homogenized to be called a lecithin solution. The grapefruit seed extract solution and the lecithin solution are mixed and homogenized at 25-30 degrees to be called a liposome solution. After slowly mixing the aqueous phase and the liposome solution at 25-30 ° C., the mixture is passed through a high pressure homogenizer to obtain an emulsion in which grapefruit seed extract-containing liposomes are uniformly dispersed, and then aged for 2-7 days. .

Comparative Example 1: The raw materials 1,11 and 12 were mixed and homogenized at 70-80 degrees to be called an aqueous phase. Mix and homogenize raw material 3 in the water phase at 70-80 ° C. Add 5 and 6 raw materials, and allow it to mature for 2-7 days.

Table 2. Example 2 and Comparative Example 2

Manufacturing method

Example 2 Raw materials 1,2,11 and 12 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 3 is dissolved in the raw material 4 to be referred to as high ginseng extract solution. Raw materials 7 and 8 are dissolved in raw material 9 at 40 ° C, cooled to 25-30 ° C, raw material 10 is added and homogenized to be called lecithin solution. The high ginseng extract solution and the lecithin solution are mixed and homogenized at 25-30 degrees to be called a liposome solution. After slowly mixing the aqueous phase and the liposome solution at 25-30 ° C., the mixture is passed through a high pressure homogenizer, and then stabilized to obtain an emulsion in which the high ginseng extract-containing liposome is uniformly dispersed.

Comparative Example 2: The raw materials 1,11 and 12 were mixed and homogenized at 70-80 degrees to be called an aqueous phase. Mix and homogenize raw material 3 in the water phase at 70-80 ° C. Add 5 and 6 raw materials, and allow it to mature for 2-7 days.

Table 3. Example 3 and Comparative Example 3

Manufacturing method

Example 3: The raw materials 1,2,11 and 12 are mixed and homogenized at 70-80 degrees to be called water phase. The raw material 3 is dissolved in the raw material 4, which is referred to as a mixed extract solution of cucumber extract, cinnamon extract, and ginger extract. Raw materials 7 and 8 are dissolved in raw material 9 at 40 ° C, cooled to 25-30 ° C, raw material 10 is added and homogenized to be called lecithin solution. The mixed extract solution and the lecithin solution are mixed and homogenized at 25-30 degrees to be called a liposome solution. After slowly mixing the aqueous phase and the liposome solution at 25-30 degrees, the mixture is passed through a high pressure homogenizer (High Pressure Homogenizer) to obtain an emulsion in which the mixed extract-containing liposome is uniformly dispersed and aged for 2-7 days.

Comparative Example 3: The raw materials 1, 11 and 12 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. Mix and homogenize raw material 3 in the water phase at 70-80 ° C. Add 5 and 6 raw materials, and allow it to mature for 2-7 days.

Table 4. Example 4 and Comparative Example 4

Manufacturing method

Example 4 Raw materials 1,2,9 and 10 are mixed and homogenized at 70-80 degrees to be called water phase. The raw material 3 is dissolved in the raw material 4 to be referred to as grapefruit extract solution. The raw materials 5 and 6 are dissolved in the raw material 7 at 40 degrees, cooled to 25-30 degrees, and the raw material 8 is added and homogenized to be called a lecithin solution. The grapefruit extract solution and the lecithin solution are mixed and homogenized at 25-30 degrees to be called a liposome solution. After slowly mixing the aqueous phase and the liposome solution at 25-30 ° C., the mixture is passed through a high pressure homogenizer, and the grapefruit extract-containing liposome is uniformly dispersed, and then stabilized for 2-7 days.

Comparative Example 4: The raw materials 1,2,9 and 10 were mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 3 is dissolved in the raw material 4 to be referred to as grapefruit extract solution. The raw material 5 is dissolved in the raw material 7 at 40 degrees, cooled to 25-30 degrees, and the raw material 8 is added and homogenized to be called a lecithin solution. The grapefruit extract solution and the lecithin solution are mixed and homogenized at 25-30 degrees to be called a liposome solution. After slowly mixing the aqueous phase and the liposome solution at 25-30 ° C., the mixture is passed through a high pressure homogenizer, and the grapefruit extract-containing liposome is uniformly dispersed, and then stabilized for 2-7 days.

[Centrifuge Stability Test]

In order to determine the centrifugation stability of the products prepared according to the above examples and comparative examples, each product was prepared by 500g, and each dose was appropriately taken and centrifuged at 4000 RPM for 10 minutes, at 8000 RPM for 10 minutes, and at 1200 RPM for 10 minutes. The results obtained are shown in the table.

Table 5. Centrifuge Stability Test Results

As can be seen from the results of the centrifugation stability test of the table, Examples 1, 2 and 3 containing the cosmetic composition stabilized plant extracts using the liposome technique are Comparative Examples 1, containing the plant extracts by a general emulsification technique. It was confirmed that there is no problem in the centrifugation stability compared to 2 and 3.

In addition, it was confirmed that Example 4, which made liposomes using lecithin and ceramide, had no problem in centrifugation stability, as compared to Comparative Example 4, which produced liposomes using only lecithin.

[Cyancular Qualitative Test]

In order to examine the stability over time of the products manufactured according to the above examples and comparative examples, 500g of each product was prepared and placed in a transparent glass container and stored at room temperature (25 °), high temperature (40 °), and daylight. Shown in the table.

Table 6. Time-lapse stability test results

As can be seen from the results of chronological stability test of the table, Examples 1 and 2 containing cosmetic compositions stabilized plant extracts using liposome technique are Comparative Examples 1 and 2 containing plant extracts by general emulsification technique. It was confirmed that there is no problem in the storage stability over time as compared to 3 and.

In addition, Example 4 in which liposomes were made using lecithin and ceramide, it was confirmed that there is no problem in storage stability over time compared to Comparative Example 4 in which liposomes were made only with lecithin.

Using the raw material prepared in the above Example was prepared in the same manner as in the formulation example below.

Prescription Example 1.

Prescription examples of skin lotion (skin lotion) in cosmetics containing plant extract-containing liposomes are as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 7. Prescription example of skin lotion (skin lotion) according to the present invention

Manufacturing method

Formulation Example 1: Raw material 2,3,4,8 was added to raw material 11 in order to dissolve it, and then the raw material 5 was heated to 60 ° C. to dissolve, followed by input and stirring raw material 10 to raw material 11. Input. Finally, the raw materials 1,6,7,9 are added and thoroughly stirred, and then aged through a high pressure homogenizer.

Comparative Example 1: Raw material 2,3,4,8 was added to raw material 11 in order, followed by stirring to dissolve it. Then, raw material 5 was heated to about 60 ° C. to dissolve, and then raw material 10 was added and stirred to prepare raw material 11 Put it in. Finally, the raw materials 6, 7, and 9 are added and sufficiently stirred, and then aged through a high pressure homogenizer.

Prescription Example 2.

Prescription examples of nutritional lotions in cosmetics containing liposomes containing plant extracts are as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 8. Prescription example of nutrition lotion according to the present invention

Manufacturing method

Formulation Example 2: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 2 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 3

Prescription examples of nutritional cream in cosmetics containing plant extract glass follicles are as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 9. Prescription example of nutrition cream according to the present invention

Manufacturing method

Formulation Example 3: Raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 3 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 4.

A prescription example of a massage cream in cosmetics containing liposomes containing plant extracts is as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 10. Prescription examples of massage cream according to the present invention

Manufacturing method

Formulation Example 4: The raw materials 8,9,10,11,13,16 are heated to 80-85 degrees with mixed agitation and put into the manufacturing part, and then the emulsifier is activated and the raw materials 2,3,4,5,6, 7,12 is heated to between 80-85 degrees and then emulsified. After emulsification, cool to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degree, add raw material 15, and cool raw material 1 to 35 degrees. After cooling to 25 degrees, it is aged.

Comparative Formulation 4: The raw materials 8, 9, 10, 11, 13 and 16 were mixed and stirred to be heated to 80-85 degrees and introduced into the manufacturing unit, followed by the operation of an emulsifier. Heat 7,7,12 to 80-85 ° C and add to emulsify. After emulsification, cool to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, cool to 25 degrees, and mature.

Prescription Example 5.

Prescription examples of nutritional essences in cosmetics containing plant extract-containing liposomes are as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 11.Prescription Examples of Nutritional Essences According to the Present Invention

Manufacturing method

Formulation Example 5: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The bion-based amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added at a constant temperature to homogenize and passed again through a high pressure homogenizer. . Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation 5: The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Claims (4)

A cosmetic composition in which a mixture of cucumber extract, cinnamon extract, ginger extract, grapefruit seed extract, grapefruit extract, red ginseng extract, licorice extract, and one or more mixtures selected from aloe extract are stabilized by using a liposome technique. As a cosmetic composition containing grapefruit seed extract containing liposomes of lecithin, ceramide, plant extract, antioxidant, solvent and emulsifier The plant extract is one or two or more mixtures selected from cucumber extract, cinnamon extract and ginger extract, grapefruit seed extract, grapefruit extract, gosam extract, licorice extract, aloe extract, and 0.1-to the total weight of the composition. Contained in an amount of 20.0%, Said lecithin is contained in an amount of 1.0-10.0% based on the total weight of the composition, Said ceramide is contained in an amount of 0.1-2.0% based on the total weight of the composition, The antioxidant may be one or two or more mixtures selected from a tocopherol derivative including tocopheryl acetate, an ascorbic acid derivative including ascorbic acid, a natural antioxidant including BHT or grapefruit seed extract, and 0.1 to a total weight of the composition. In an amount of -5.0%, The solvent is one or two mixtures selected from propylene glycol and butylene glycol, contained in an amount of 0.1-40.0% based on the total weight of the composition, The emulsifying stability aid is a plant extract-containing cosmetic composition, characterized in that it is contained in an amount of 0.1-20.0% based on the total weight of the composition as one or two or more mixtures selected from glycerin, ziitol, or a natural polymer compound. A method for producing a cosmetic composition comprising a plant extract-containing liposome in which plant extract-containing liposomes are evenly dispersed by passing a mixture containing purified water, lecithin, ceramide and plant extract through a High Pressure Homogenizer. The cosmetic composition of claim 1, wherein the cosmetic is formulated as a lotion (skin lotion), nutrition lotion, nutrition cream, massage cream or nutrition essence.

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