KR100670440B1 - The stability technology of using the technology of the liposome including adenosine & oil soluble licorice extract and the components of cosmetics including the liposome and the method of manufacturing the components - Google Patents

Abstract

A cosmetic composition is provided to show excellent transdermal absorptivity of adenosine and oil soluble licorice extract, and be able to stably preserve the composition for a long period of time without losing the activity of the adenosine and licorice extract by containing liposomed adenosine and soluble licorice extract. The cosmetic composition stabilizing adenosine and oil soluble licorice extract through the liposome technique comprises 0.01-4.0 wt. of adenosine, 0.01-5 wt.% of the oil soluble licorice extract, 1.0-10.0 wt.% of lecithin, 0.1-2.0 wt.% of ceramide, 0.1-5.0 wt.% of tocopheryl acetate, 0.01-1.0 wt.% of citric acid, and 0.1-40.0 wt.% of at least one emulsification stabilizing supplement selected from the group consisting of propyleneglycol, butyleneglycol, glycerine, xylitol and natural polymer compounds.

Description

The stability technology of using the technology of the liposome including adenosine & oil soluble licorice extract and the components of cosmetics including the liposome and the method of manufacturing the components.}

Figure 1 shows the cell proliferation effect according to the concentration of the cosmetic composition containing adenosine.

Figure 2 shows the collagen synthesis promoting effect according to the concentration of the cosmetic composition containing adenosine.

Figure 3 shows the whitening effect of the concentration of the cosmetic composition containing the oil-soluble licorice extract.

The present invention relates to a stabilization technique using a liposome technique of a bioactive substance, and a cosmetic composition containing the same and a method for producing the same.

In recent years, interest in functional cosmetics containing specific bioactive substances for the purpose of delaying skin aging and whitening has been increasing and many studies have been conducted. The present invention also relates to such a functional cosmetic composition comprising adenosine having a function of inhibiting skin aging and a cosmetic composition containing an oil-soluble licorice extract for whitening the skin. In order to apply the function of such adenosine or oil-soluble licorice extract to cosmetics, cosmetics have been proposed in which adenosine or oil-soluble licorice extract is added to cosmetics. However, conventional cosmetics are simple emulsified type or gel type products prepared by simply adding adenosine or oil-soluble licorice extract to the cosmetic composition, and it is difficult to formulate a sufficient amount in the cosmetic and is difficult to penetrate into the skin even when formulated. In addition, the preservation of cosmetics has a drawback that is limited to the application of precipitation. The reason for this is that adenosine is hardly soluble in low temperature purified water, but melts only at high temperature, that is, above 70 ° C, so that even if it is applied to cosmetics, it is difficult to apply an appropriate amount due to separation or sedimentation.

On the other hand, even in the case of liposome cosmetics because precipitation occurs because of the solubility characteristics of adenosine, it is difficult to expect skin penetration, which is an advantage of liposomes, so there was a problem in selecting a solvent at the time of prescription.

Under such circumstances, the inventors of the present invention have conducted a thorough study to provide a composition of adenosine and oil-soluble licorice extract containing cosmetics that have excellent skin penetration and excellent stability without loss of long-term activity without the above-mentioned problems. The present invention has been accomplished by discovering that the above object can be achieved by liposome-forming and adding it to a cosmetic.

That is, an object of the present invention is 1.0-10.0% lecithin of the total composition weight, 0.1-2.0% ceramide of the total weight of the composition, 0.01-4.0% adenosine of the total weight of the composition, 0.01-5.0% of the total weight of the composition To provide adenosine and oil-soluble licorice extract-containing cosmetic composition, characterized in that it contains liposome consisting of 0.1-1.0% of the citric acid of the total weight of the licorice extract and composition.

Still another object of the present invention is to pass a mixture containing purified water, lecithin, ceramide, tocopheryl acetate, adenosine, oil-soluble licorice extract and citric acid through a High Pressure Homogenizer to adenosine and oil-soluble licorice extract-containing liposomes. It is to provide a method for producing a cosmetic composition evenly dispersed.

Hereinafter, the present invention will be described in more detail.

Since the cosmetic composition provided according to the present invention contains liposome-ized adenosine and oil-soluble licorice extract, it has excellent transdermal absorption of adenosine and oil-soluble licorice extract, and can be stably preserved for a long time without losing the activity of adenosine and oil-soluble licorice extract. .

In the present invention, a material for forming liposomes containing adenosine in contact with adenosine to be liposomed is used with lecithin, and is used in an amount of 1.0% -10.0% based on the total weight of the composition.

The ceramides used in the present invention are used in amounts of 0.1-2.0% based on the total weight of the composition.

Tocopheryl acetate used in the present invention is used in an amount of 0.1-5.0% based on the total weight of the composition.

Citric acid is used in the present invention to increase the solubility of adenosine and is used in an amount of 0.01-1.0% based on the total weight of the composition.

The cosmetic composition of the present invention may contain an emulsifying stabilizer to stabilize adenosine and oil-soluble licorice extract, and for example, polymers such as propylene glycol, butylene glycol, glycerin, xyitol, natural polymer compounds, etc., with respect to the total weight of the composition. It can be used in an amount of 0.1-40.0%.

According to the method of the present invention, first, purified water and citric acid were stirred with a homomixer at 70-80 degrees, cooled, and then maintained at a temperature of about 50-60 degrees to form a homogeneous aqueous solution, and the adenosine was dissolved at 50-60 degrees with an aqueous solution. To make an adenosine solution. Lecithin and ceramide are dissolved in propylene glycol at 40 ° C, oil-soluble licorice extract and tocopheryl acetate are added to make a homogenized lecithin solution, and the lecithin solution is slowly added to the prepared aqueous solution to obtain an emulsion. The obtained emulsion is passed through a high pressure homogenizer to obtain an emulsion in which adenosine and oil-soluble licorice extract-containing liposomes are evenly dispersed.

The adenosine and oil-soluble licorice extracts that have been used in conventional cosmetics by the method of the present invention as described above are more stable and blended into cosmetics without loss of activity, and also improve the permeability when applied to the skin collagen production function and utility of adenosine It has become possible to provide an emulsion type cosmetic that can sufficiently exhibit the skin whitening function of licorice extract.

Hereinafter, the present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

Table 1. Example 1 and Comparative Example 1

Manufacturing method

Example 1 Raw materials 1,2,3,12 and 13 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 4 is dissolved and silicified at 50-60 degrees in the water phase and is called adenosine solution. The raw materials 7 and 8 are dissolved and homogenized in the raw material 9 at 40 degrees, and then the raw materials 10 and 11 are added and homogenized to be called a lecithin solution. The adenosine solution and the lecithin solution were slowly mixed and homogenized at 30-40 degrees, and then passed through a high pressure homogenizer to obtain an emulsion of adenosine and an oil-containing licorice extract containing a uniformly dispersed emulsion. -Maturate for 7 days.

Comparative Example 1: The raw materials 1, 4, 12 and 13 are mixed and homogenized at 70-80 degrees to be called adenosine solution. Dissolve and homogenize raw material 5 in adenosine solution at 70-80 degrees, add raw materials 6 and 11, homogenize and mature for 2-7 days.

Table 2. Example 2 and Comparative Example 2

Manufacturing method

Example 2 Raw materials 1,2,3,12 and 13 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 4 is dissolved in a water phase at 50-60 degrees and silicified to be called adenosine solution. The raw materials 7 and 8 are dissolved and homogenized in the raw material 9 at 40 degrees, and then the raw materials 10 and 11 are added and homogenized to be called a lecithin solution. The adenosine solution and the lecithin solution are gradually mixed and homogenized at 30-40 degrees, and then passed through a high pressure homogenizer to obtain an emulsion of adenosine and an oil-soluble licorice extract containing a uniformly dispersed emulsion. -Maturate for 7 days.

Comparative Example 2: The raw materials 1, 4, 12 and 13 are mixed and homogenized at 70-80 degrees to be called adenosine solution. Dissolve and homogenize raw material 5 in adenosine solution at 70-80 degrees, add raw materials 6 and 11, homogenize and mature for 2-7 days.

Table 3. Example 3 and Comparative Example 3

Manufacturing method

Example 3: According to a conventional simple emulsification method, the raw materials 1, 7 and 8 were mixed at 70-80 degrees, homogenized by adding the raw material 6, and then mixed well by adding the raw materials 4 and 5, and then 30-35. In the figure, the remaining raw material 3 is mixed and homogenized and aged for 2-7 days.

Comparative Example 3 After mixing the raw materials 1,2,7 and 8 at 70-80 degrees according to the conventional simple emulsification method and homogenizing by adding the raw material 6, homogenizing by mixing the raw materials 4 and 5 well 2 -Maturate for 7 days.

Table 4. Example 4 and Comparative Example 4

Manufacturing method

Example 4 Raw materials 1,2,3,10 and 11 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 4 is dissolved in a water phase at 50-60 degrees and silicified to be called adenosine solution. The raw materials 5 and 6 are dissolved and homogenized in the raw material 7 at 40 degrees, and then the raw materials 8 and 9 are added and homogenized to be called a lecithin solution. The adenosine solution and the lecithin solution were slowly mixed and homogenized at 30-40 degrees, and then passed through a high pressure homogenizer to obtain an emulsion of adenosine and an oil-containing licorice extract containing a uniformly dispersed emulsion. -Maturate for 7 days.

Comparative Example 4: The raw materials 1, 3, 10 and 11 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 4 is dissolved in an aqueous phase at 70-80 degrees and silicified to be called an adenosine solution. The raw materials 5 and 6 are dissolved and homogenized in the raw material 7 at 40 degrees, and then the raw materials 8 and 9 are added and homogenized to be called a lecithin solution. The adenosine solution and the lecithin solution were slowly mixed and homogenized at 30-40 degrees, and then passed through a high pressure homogenizer to obtain an emulsion of adenosine and an oil-containing licorice extract containing a uniformly dispersed emulsion. -Maturate for 7 days.

[Centrifuge Stability Test]

In order to determine the centrifugation stability of the products manufactured according to the above examples and comparative examples, 500g of each product was prepared and taken in an appropriate amount, followed by centrifugation at 10 minutes at 4000 RPM, 10 minutes at 8000 RPM, and 10 minutes at 12000 RPM. The results obtained are shown in the table.

Table 5. Centrifuge Stability Test Results

As can be seen from the results of the centrifugation stability test of the table, Examples 1, 2, and 3 containing the cosmetic composition stabilized adenosine using the liposome technique are Comparative Examples 1, 2, and 3 containing adenosine by the general emulsification technique. It was confirmed that there is no problem in the centrifugation stability compared to 3.

In addition, Example 4 using the aqueous citric acid solution as the solvent of adenosine was confirmed that there is no problem in the centrifugation safety compared to Comparative Example 4 using the aqueous solution as the adenosine solvent.

Using the raw material prepared in the above Example was prepared in the same manner as in the formulation example below.

Prescription Example 1.

The following is a prescription example of a lotion (skin lotion) among cosmetics containing adenosine-containing liposomes. Herein, adenosine and oil-soluble licorice extract-containing liposomes are those of Example 1.

Table 6. Examples of prescription of lotion (skin lotion) according to the present invention

Manufacturing method

Formulation Example 1: Raw material 2,3,4,8 was added to raw material 11 in order, and then dissolved by stirring. Then, raw material 5 was heated to 60 ° C. to dissolve, and then raw material 10 was added and stirred to raw material 11. Input. Finally, the raw materials 1,6,7,9 are added and sufficiently stirred, and then aged through a high pressure homogenizer.

Comparative Example 1: Raw material 2,3,4,8 was added to raw material 11 in order, followed by stirring to dissolve it. Then, raw material 5 was heated and dissolved at about 60 ° C., and then raw material 10 was added and stirred to prepare raw material 11 Put it in. Finally, the raw materials 6, 7, and 9 are added and sufficiently stirred, and then aged through a high pressure homogenizer.

Prescription Example 2.

Prescription examples of nutritional lotions in cosmetics containing adenosine and oil-soluble licorice extracts are as follows. Herein, adenosine and oil-soluble licorice extract-containing liposomes are those of Example 1.

Table 7. Prescription examples of nutrition lotion according to the present invention

Manufacturing method

Formulation Example 2: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Scream Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 2: The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 3

Prescription examples of nutritional creams in cosmetics containing liposomes containing adenosine and oil-soluble licorice extract are as follows. Herein, adenosine and oil-soluble licorice extract-containing liposomes are those of Example 1.

Table 8. Prescription example of nutrition cream according to the present invention

Manufacturing method

Formulation Example 3: Raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 3 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 4.

A prescription example of a massage cream in a cosmetic containing adenosine and a liposome containing a useful licorice extract is as follows. Herein, adenosine and oil-soluble licorice extract-containing liposomes are those of Example 1.

Table 9. Prescription example of massage cream according to the present invention

Manufacturing method

Formulation Example 4: The raw materials 8,9,10,11,13,16 are heated to 80-85 degrees with mixed agitation, put into the manufacturing unit, and then the emulsifier is activated. 7,12 is heated to between 80-85 degrees and then emulsified. After emulsification, cool down to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, and cool raw material 1 to 35 degrees. After cooling to 25 degrees, it is aged.

Comparative Formulation Example 4: The raw materials 8,9,10,11,13,16 were mixed and stirred to be heated to 80-85 ° C and introduced into the manufacturing unit, followed by the operation of an emulsifier. Heat 7,7,12 to 80-85 ° C and add to emulsify. After emulsification, cool to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, cool to 25 degrees, and mature.

Prescription Example 5.

Prescription examples of nutritional essences in cosmetics containing adenosine and liposomes containing a useful licorice extract are as follows. Herein, adenosine and oil-soluble licorice extract-containing liposomes are those of Example 1.

Table 10. Prescription examples of nutritional essences according to the present invention

Manufacturing method

Formulation Example 5: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 5: The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Claims (4)

Cosmetic composition wherein adenosine and oil-soluble licorice extract are stabilized using liposome technique. A cosmetic composition containing adenosine and an oil-soluble licorice extract containing liposomes of lecithin, ceramide, tocopheryl acetate, adenosine, oil-soluble licorice extract, citric acid and emulsifying eye preparation, Adenosine described above is contained in an amount of 0.01-4.0% based on the total weight of the composition, The oil-soluble licorice extract described above is contained in an amount of 0.01-5.0% based on the total weight of the composition, Said lecithin is contained in an amount of 1.0-10.0% based on the total weight of the composition, Said ceramide is contained in an amount of 0.1-2.0% based on the total weight of the composition, Tocopheryl acetate as described above is contained in an amount of 0.1-5.0% based on the total weight of the composition, The citric acid is contained in an amount of 0.01-1.0% based on the total weight of the composition, The above emulsifying stability aids include adenosine, characterized in that it is contained in an amount of 0.1-40.0% based on the total weight of the composition as one or two or more mixtures selected from propylene glycol, butylene glycol, glycerin, gyritol or natural polymer compounds. Cosmetic composition containing a soluble licorice extract. Mixtures containing purified water, lecithin, ceramide, tocopheryl acetate, adenosine, oil-soluble licorice extract and citric acid are passed through a High Pressure Homogenizer to provide evenly dispersed adenosine and oil-soluble licosome containing adenosine and oil-soluble licorice extract A method for producing a cosmetic composition containing an extract-containing liposome. The cosmetic composition of claim 1, wherein the cosmetic is formulated as a lotion (skin lotion), nutrition lotion, nutrition cream, massage cream or nutrition essence.

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