KR102159936B1 - Specimen vial container configured to mix plurality of liquid by pressing cap - Google Patents

Abstract

The present invention provides a sample vial container which can reduce a period during which a worker is exposed to formalin. The sample vial container includes: a cap including a first liquid received in a first space sealed by a sealing sheet; and a container main body configured to be coupled to the bottom of the cap and providing a second space in which a second liquid is received, wherein when the top of the cap is pressed, a cutting unit in the first space is moved downwardly to incise the sealing sheet, the first liquid is a liquid material containing formaldehyde, and the second liquid is a liquid material containing no formalin or containing formalin at a lower concentration as compared to the first liquid.

Description

A sample vial container configured to mix multiple types of liquids by pressing the cap {SPECIMEN VIAL CONTAINER CONFIGURED TO MIX PLURALITY OF LIQUID BY PRESSING CAP}

The present invention relates to a sample vial container for testing liquid cells in a sample. Specifically, it relates to a sample vial container configured to mix and use a plurality of types of liquids. More particularly, it relates to a sample vial container that is configured to mix and use a plurality of types of liquids, thereby reducing the time the operator is exposed to harmful substances.

Smear test is a method of bacteriological testing, in which a sample is smeared on a slide glass and then stained and observed under a microscope. For example, the bacteriostatic smear test may be performed through microscopic observation after thinly applying a sample of cells, tissues, etc. collected from humans to a slide glass and selectively staining. A liquid based cytology technique that replaces the conventional cytology test (Papanicolaou) and stores the collected cell sample in a preservative solution, and then places the cell sample in which the monolayer of the preserved cells is uniformly dispersed on a slide to test. It was also developed. The liquid cell test can improve the fixation of cells and minimize obscure factors compared to the conventional cytology test, thereby improving the specificity and sensitivity of the test.

This intensive smear test has the advantage of being able to quickly detect and start treatment of active tuberculosis patients compared to other methods because it is possible to quickly determine the presence of infection with simple staining for bacteriological diagnosis.

On the other hand, cell tissues collected from the patient's lesions are transported to a place with test equipment for accurate diagnosis of the disease. In this case, the movement of the collected cell tissue needs to be preserved for a very long time, and therefore, it is stored in a preservation solution (or fixative solution). The preservative solution maintains and preserves the state at the time of collection so that the cell tissues that have fallen out of humans do not die, decompose, or change their shape, thereby maintaining a suitable state for observing the structure of the tissues, analyzing, or making samples. do. As a preservative, a mixed solution containing formaldehyde is usually used.

Formaldehyde is most commonly used as a preservative because of its coagulation and polymerization action of proteins. However, formalin (formaldehyde solution) is not only very toxic to the human body, but also volatile, so care must be taken when handling. In addition, when volatilized formalin is left in the air for a long time, first-class carcinogens may be produced. If a person is exposed to gaseous formalin, formaldehyde can penetrate through the skin or mucous membranes. In particular, continuous inhalation of formaldehyde may cause disorders of the central nervous system or heart failure. Therefore, a high degree of care is required in the handling of formalin.

However, in the process of preserving cells, examiners such as clinicians or pathologists are always exposed to formalin. Therefore, when handling formalin, the inspector wears a gas mask to minimize the harm caused by formalin, but the health status of the worker is nevertheless exposed to harmful factors. For this reason, various attempts have been made to seal the preservative.

For example, Patent Document 1 (Korean Registered Patent No. 10-1880052) discloses a sample storage container including a container body, a cutter member, a storage solution receiving portion, a lid and a temporary fixing member. In addition, Patent Document 2 (Korean Registered Patent No. 10-1934819) discloses a specimen container including a specimen receiving portion and a cap portion. Patent Literature 1 and Patent Literature 2 disclose a structure in which a container body and a lid are rotated to cut off a sealing film that seals a storage solution.

For another example, Patent Document 3 (Korean Registered Patent No. 10-1874304) discloses a human tissue preservation device including a storage housing, a screen net, a sorting member, a pressing rod, and an aluminum film. In addition, Patent Document 4 (Korean Patent Registration No. 10-1736745) discloses a specimen container for preserving tissue including a cap portion, a housing, a slit portion, and a support jaw. Patent Literature 3 and Patent Literature 4 disclose a structure in which a sealing film for sealing a preservative liquid is cut by applying pressure to the lid.

Korean Registered Patent Publication No. 10-1880052, (Patent Document 2) Korean Registered Patent Publication No. 10-1934819, (Patent Document 3) Korean Patent Publication No. 10-1874304 (Patent Document 4) Korean Registered Patent Publication No. 10 -No.1736745

The specimen containers of the aforementioned Patent Documents 1 to 4 are configured to seal the preservative solution using a sealing film, and to cut the sealing film through operation during use. In addition, it is suggested that formalin is used as a preservative.

However, the process by which the tester is exposed to formalin may occur not only in the process of injecting a cell sample into a sample container, but also in the process of preparing formalin suitable for cell fixation. That is, even in the process of preparing or preparing a preservative solution that has an appropriate formaldehyde concentration and includes other additional components, the worker may be exposed to formalin. On the other hand, the above-described Patent Documents 1 to 4 do not reveal recognition of such a problem, and overlook the problem that the worker is exposed to formalin in the process of manufacturing formalin.

Accordingly, the problem to be solved by the present invention is to provide a sample vial container capable of further reducing the time the worker is exposed to harmful substances such as formalin. At the same time, it is to provide a sample vial container that allows the operator to easily cut the sealing sheet and mix the preservative solution and the sample even if the operator applies relatively little force.

The problems of the present invention are not limited to the technical problems mentioned above, and other technical problems that are not mentioned will be clearly understood by those skilled in the art from the following description.

A sample vial container according to an embodiment of the present invention for solving the above problem includes: a cap containing a first liquid accommodated in a first space sealed by a sealing sheet; And a container body configured to be coupled to a lower end of the cap and providing a second space in which a second liquid is accommodated, wherein when the upper end of the cap is pressed, a cutout in the first space moves downward to thereby remove the sealing sheet. It is configured to be cut, wherein the first liquid is a liquid material containing formaldehyde, and the second liquid is a liquid material that does not contain formaldehyde or has a lower concentration of formaldehyde than the first liquid.

In some embodiments, the sample vial container may further include a filtration unit coupled to the lower end of the cap and inserted into the container body.

Here, the filtration unit includes a bottom portion having an opening, a sidewall portion protruding upward in a cylindrical shape from an edge of the bottom portion, and extending in a first direction from the bottom portion, and a first contacting the inner surface of the sidewall portion. It may include a first protrusion, and a second protrusion protruding upward from the bottom part and extending in a second direction crossing the first direction, and contacting an inner surface of the sidewall part.

In addition, the opening of the bottom portion may be located only inside a space surrounded by the first and second projections.

The cap and the container body may be screwed together.

In addition, the cap and the filtration unit may be force-fitting.

Details of other embodiments are included in the detailed description. Further, the effects according to the embodiments of the present invention are not limited by the contents illustrated above, and more various effects are included in the present specification.

1 is a perspective view of a sample vial container according to an embodiment of the present invention.
2 is an exploded perspective view of the sample vial container of FIG. 1.
3 is a cross-sectional perspective view of the sample vial container of FIG. 2.
4 is a rear perspective view of the cap of FIG. 3.
5 to 8 are diagrams for explaining a process and an effect of using the sample vial container of FIG. 1.
9 is a perspective view of a sample vial container according to another embodiment of the present invention.
10 is an exploded perspective view of the sample vial container of FIG. 9.
11 is a cross-sectional perspective view of the sample vial container of FIG. 10.
12 is a rear perspective view of the cutting unit of FIG. 11.
13 is a perspective view of the filtration unit of FIG. 11.
14 to 17 are views for explaining a process and an effect of using the sample vial container of FIG. 9.

Advantages and features of the present invention, and a method of achieving them will become apparent with reference to the embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various forms different from each other, and only the embodiments make the disclosure of the present invention complete, and those skilled in the art to which the present invention belongs. It is provided to fully inform the person of the scope of the invention, and the invention is only defined by the scope of the claims.

That is, various changes may be made to the embodiments suggested by the present invention. The embodiments described below are not intended to be limited to the embodiments, and should be understood to include all changes, equivalents, and substitutes for them.

The terms used in the present specification are for describing exemplary embodiments and are not intended to limit the present invention. In this specification,'and/or' includes each and every combination of one or more of the recited items. In addition, the singular form also includes the plural form unless otherwise stated in the text.

The spatially relative terms used in this specification, such as'below','beneath','lower','above', and'upper', are shown in the drawings. As it may be, it can be used to easily describe the correlation between one component or device and other components or devices. Spatially relative terms should be understood as terms including not only the directions shown in the drawings, but also different directions of the components when used. For example, when a component shown in the drawing is turned over, a component described as'below or beneath' of another component may be placed on'above' of another component. Accordingly, the exemplary term'below' may be used including both the lower and upper directions.

As used herein,'comprises' and/or'comprising' does not exclude the presence or addition of one or more other elements other than the mentioned elements. Numerical ranges indicated using'to' represent numerical ranges including the values listed before and after them as lower and upper limits, respectively. "About" or "approximately" means a value or numerical range within 20% of the value or numerical range described thereafter.

The term'handling method' as used herein is meant to include a method of manufacturing, a method of preparation, a method of use, a method of transport, a method of storage, a method of trading, a method of cooperation, and the like.

For convenience of explanation, the first direction (X) refers to an arbitrary direction in the plane, and the second direction (Y) refers to a direction intersecting the first direction (X) in the plane. In addition, the third direction Z means a direction perpendicular to the plane. However, of course, the matters described in the claims are not limited thereto. Unless otherwise defined, a'plane' means a plane to which the first direction X and the second direction Y belong. In addition, the'planar view' refers to a point in time when the component represented in the drawing is viewed from one side in the third direction (Z) and the component is placed on the plane.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view of a sample vial container 10 according to an embodiment of the present invention. 2 is an exploded perspective view of the specimen vial container 10 of FIG. 1. 3 is a cross-sectional perspective view of the specimen vial container 10 of FIG. 2. 4 is a rear perspective view of the cap 101 of FIG. 3.

1 to 4, the specimen vial container 10 according to the present embodiment has a cap 101 having a closed first space S1 and a container body 201 having an open second space S2. ). In addition, the sample vial container 10 may further include a filtration unit 301. The sample vial container 10 may be a container for performing a biopsy or a liquid based cytology, but the present invention is not limited thereto.

First, the cap 101 will be described. The cap 101 may have a sealed first space S1. A liquid substance (eg, first liquid F) may be accommodated in the first space S1. For example, the first liquid F may be a preservative solution containing a harmful component. Specifically, the preservative may be a solution containing a high concentration of formaldehyde.

In some embodiments, the lower limit of the formaldehyde concentration in the first liquid F is about 25.0% (v/v), or about 26.0% (v/v), or about 27.0% (v/v), or about 28.0. % (v/v), or about 29.0% (v/v), or about 30.0% (v/v), or about 31.0% (v/v), or about 32.0% (v/v), or about 33.0 % (v/v), or about 34.0% (v/v), or about 35.0% (v/v).

The upper limit of the formaldehyde concentration in the first liquid (F) is not particularly limited, but for example, about 50.0% (v/v), or about 49.0% (v/v), or about 48.0% (v/v), Or about 47.0% (v/v), or about 46.0% (v/v), or about 45.0% (v/v), or about 44.0% (v/v), or about 43.0% (v/v), Or about 42.0% (v/v), or about 41.0% (v/v), or about 40.0% (v/v). Alternatively, it may be a formaldehyde stock solution.

Specifically, the cap 101 is from the ceiling part 111 at the top, the pressing part 111p located inside the ceiling part 111, the cutout 171 protruding downward from the pressing part 111p, and the ceiling part 111 The fastening body 121 protruding downward and having a first thread 121s (or cap thread) formed on the inner surface thereof, and a first side wall part protruding downward from the ceiling 111 and forming a first space S1 ( 131) (or the cap sidewall portion), and may further include a sealing sheet 150 disposed below the first sidewall portion 131.

The ceiling part 111, the fastening body part 121, and/or the first sidewall part 131 may be integrally formed without a physical boundary with each other. Further, the ceiling portion 111, the pressing portion 111p, and/or the cutout portion 171 may also be integrally formed without a physical boundary with each other.

The ceiling part 111, the fastening body part 121, and the first side wall part 131 may be made of synthetic resin or the like. For example, a typical human grip force, such as a force of about 100 kgf or less, or about 90 kgf or less, or about 80 kgf or less, or about 70 kgf or less, or about 60 kgf or less, or about 50 kgf or less, may have been applied. It may have strength and stiffness that does not substantially change its appearance. That is, the ceiling part 111, the fastening body part 121, and the first side wall part 131 are broken, crushed, compressed, expanded, irreversibly bent, or irreversibly bent by a normal external force. , It may be made of a material having high strength and rigidity that does not cause external deformation such as folding or tearing. Examples of the material may include polycarbonate-based resins, but the present invention is not limited thereto.

In some embodiments in which the ceiling portion 111, the pressing portion 111p and/or the cutout portion 171 are integrally formed, the pressing portion 111p is made of substantially the same material as the ceiling portion 111, but has a thinner thickness. Can have. Accordingly, the pressing portion 111p may be reversibly bent and may have elasticity. That is, the pressing part 111p may be configured to be bent by pressure applied by a typical human and then restored to its original position.

The ceiling part 111 may have a substantially annular shape with a center open in a plan view. The ceiling part 111 may be a part connecting the fastening body part 121, the first sidewall part 131, and the pressing part 111p in a horizontal direction. The ceiling portion 111 and the pressing portion 111p, which will be described later, may be portions forming the upper exterior of the cap 101.

The pressing part 111p may be disposed on the inner edge of the annular ceiling part 111. The pressing part 111p may be formed to protrude upward and may be configured to be deformed in the vertical direction (eg, the third direction Z) or moved in the vertical direction. The pressing part 111p may be a part of the specimen vial container 10 to which a user applies pressure with a finger or the like. As described above, the pressing portion 111p may have elasticity compared to the ceiling portion 111 and the like.

In addition, the cutout 171 may be located in the first space S1 of the cap 101. The cutout 171 may be configured to move in the vertical direction according to the pressure applied to the pressing part 111p. In this embodiment, the incision 171 is integrated with the cap 101 to illustrate a case in which the incision 171 is configured to move downward as a downward pressure is applied to the pressing portion 111p, but in another embodiment, the incision The part 171 may be configured separately from the cap 101. In this case, it is the same that the cut-out portion is configured to move downward as a downward pressure is applied to the pressing portion 111p.

In an exemplary embodiment, the cutout 171 is a rod extending in the third direction (Z), a blade disposed on the side of the rod and having an approximately'+' shape in a plane and extending in the third direction (Z). May contain wealth.

The fastening body portion 121 may protrude downward from the outer peripheral edge of the ceiling portion 111. The fastening body 121 may have an approximately annular shape. In an exemplary embodiment, the fastening body portion 121 may be provided with a means capable of being reversibly coupled to the container body 201 to be described later on its inner circumferential surface. For example, the coupling means may be a first thread 121s (or a cap thread). The term'reversible coupling' as used herein refers to a coupling capable of repeatedly fastening and releasing between components without destruction or deformation of the components. In a state in which the cap 101 and the container body 201 are partially or completely coupled, the fastening body portion 121 may be located outside the container body 201. That is, the inner diameter of the fastening body 121 may be larger than the maximum outer diameter of the container body 201 to be described later.

The first sidewall portion 131 may protrude downward from the inner peripheral edge of the ceiling portion 111. The first sidewall portion 131 may have a substantially cylindrical shape with an open lower portion. Further, in a plan view, the first sidewall portion 131 may be surrounded by the fastening body portion 121. The protruding length of the first sidewall portion 131 in the third direction Z may be greater than the protruding length of the fastening body portion 121 in the third direction Z. In a state in which the cap 101 and the container body 201 are partially or completely coupled, the first side wall portion 131 may be inserted into the container body 201. That is, the outer diameter of the first side wall portion 131 may be smaller than the inner diameter (or the minimum inner diameter) of the container body 201 to be described later. The first side wall portion 131 and the fastening body portion 121 may be spaced apart from each other, and a lower surface of the ceiling portion 111 may be partially exposed between them.

In some embodiments, an outer surface (and an inner surface) of the first sidewall portion 131 may be in a flat state without having a thread or the like. Through this, as will be described later, it is possible to form a rotation non-limiting coupling with the filtering unit 301. The term'non-rotational coupling' as used herein refers to a coupling in which fastening and disengaging between components are not changed through relative rotation between components, and at the same time, rotation of other components based on a certain component is free. Examples of rotational non-limiting coupling include clip coupling, force fitting (or fitting coupling), and the like. In addition, the first sidewall portion 131 may form a combination with the filtering unit 301 in which movement in the vertical direction (eg, the third direction Z) is free.

The sealing sheet 150 may have an approximately circular shape. The sealing sheet 150 may be disposed or adhered to the lower end of the first sidewall portion 131 to form a sealed first space S1. Specifically, the lower surface of the pressing part 111p, the inner surface of the first sidewall part 131 and the upper surface of the sealing sheet 150 may form a first space S1 together.

The sealing sheet 150 is made of a material that does not transmit liquid substances, but may be made of a material having weaker strength and rigidity compared to the ceiling portion 111 of the cap 101. For example, the sealing sheet 150 may be made of a metal thin film such as silver foil, aluminum foil, or a synthetic resin thin film that can be partially cut, cut, torn, damaged, or opened by a conventional external force. .

Next, the container body 201 will be described. The container body 201 may have a second space S2 that can be opened or sealed. A liquid substance (eg, the second liquid W) may be accommodated in the second space S2. The second liquid W can be distinguished from the first liquid F in terms of the concentration of formaldehyde. Specifically, the second liquid W may not contain formaldehyde at all, or may have a lower concentration of formaldehyde than at least the first liquid F.

The second liquid (W) has a water content of about 95.0% (v/v) or more, or about 96.0% (v/v) or more, or about 97.0% (v/v) or more, or about 98.0% (v/v) ) Or more, or about 99.0% (v/v) or more of a liquid substance. Or it may contain pure water.

In an exemplary embodiment, the second liquid W may include a physiological saline solution having a sodium chloride (NaCl) concentration of 1.0% or less, or about 0.9%. When physiological saline is used as the second liquid (W), it is possible to minimize tissue deformation such as moisture inflow into the sample for a period of time after the initial sample is injected and before being mixed with the first liquid (F). However, the present invention is not limited thereto, and in another embodiment, the second liquid W may further include an additional component in the physiological saline solution, such as another component advantageous for preservation or fixation of cells. That is, the second liquid W may be a solution in which 0.1% (v/v) to 1.0% (v/v) of sodium chloride is dissolved. In addition, the volume of the second liquid W may be selected in consideration of the concentration and volume of the first liquid F, but may be, for example, about 3ml to 10ml, or about 4ml to 6ml.

In addition, the second space S2 may provide a space in which a sample such as cells, tissues, and cell tissues collected from the subject is accommodated when the sample vial container 10 is used. That is, the second liquid W may be located in a space in which the specimen is accommodated. In general, in the process of collecting cells, testers such as pathologists, clinicians, etc. (users of the sample vial container 10) grasp the sample using tools such as biopsies forceps or biopsies tweezers and insert them into the container body 201. I can. At this time, it is not easy to put the sample grasped by the tool into the container body 201 because it is common for the sample collected immediately to have viscosity. In particular, since the color of the tissue is usually pale, white or transparent, it is difficult for an examiner to check whether the tissue cells have been correctly introduced.

The sample vial container 10 according to the present embodiment accommodates a liquid substance, that is, a second liquid W, in the container body 201, thereby placing the biopsy forceps in which tissue cells are gripped in the second liquid W and stirring. It has the advantage of being able to easily import samples such as tissue cells. Accordingly, there is no need to apply a physical force in the process of separating the specimen from the tool, and thus, problems such as crushing or damage of the specimen can be minimized.

When the container body 201 and the cap 101 are separated, the second space S2 is an open space, but when the container body 201 and the cap 101 form a bond, the second space S2 Can be completely sealed from outside and outside air.

Specifically, the container body 201 protrudes upward from the first bottom part 211 (or container bottom part) and the first bottom part 211 at the lower end, and a second thread 221s (or container thread) on the outer surface. Is formed and includes a second side wall portion 221 (or container side wall portion) forming a second space S2, and further includes one or more support portions 251 protruding upward from the first bottom portion 211 can do.

The first bottom part 211, the second side wall part 221, and the support part 251 may be integrally formed without a physical boundary with each other. The first bottom part 211, the second side wall part 221, and the support part 251 of the container body 201 may be made of synthetic resin or the like. For example, the change in appearance when a force of about 100 kgf or less, or about 90 kgf or less, or about 80 kgf or less, or about 70 kgf or less, or about 60 kgf or less, or about 50 kgf or less is applied to a normal human grip is substantially It can have strength and stiffness that do not occur as a result. That is, the container body 201 has a strength that does not cause any external deformation such as cracking, crushing, compressing, expanding, irreversibly bending, irreversibly folding, or tearing by a conventional external force. It can be made of a material with high rigidity. The container body 201 may be made of the same or different material as the ceiling part 111 of the cap 101 described above.

The first bottom part 211 may be substantially circular in plan view. The first bottom part 211 may be a part forming the outer bottom surface of the container body 201. Also, the upper surface of the first bottom part 211 may contribute to the formation of the second space S2.

The second sidewall portion 221 may protrude upward from the outer peripheral edge of the first bottom portion 211. The second sidewall portion 221 may have a substantially open cylindrical shape. The outer diameter of the second sidewall portion 221 may be smaller than the inner diameter of the fastening body portion 121, and the inner diameter of the second sidewall portion 221 may be larger than the outer diameter of the first sidewall portion 131. Accordingly, the second side wall portion 221 is partially inserted into the spaced space between the fastening body portion 121 and the first side wall portion 131 described above, and the first side wall portion 131 is a second space (S2) Can be inserted into In some embodiments, in a state in which the cap 101 and the container body 201 are fully coupled, for example, in a fully screwed state, the upper end of the second sidewall portion 221 may abut the lower surface of the ceiling portion 111. .

In an exemplary embodiment, the container body 201 may be provided with a means capable of reversibly engaging the cap 101 described above on its outside. For example, the coupling means may be a second thread 221s (or a container thread). In order to use the sample vial container 10 according to the present embodiment for liquid cell testing, it is necessary to engage and release the cap 101 and the container body 201 multiple times. For example, one combination is required in the process of preparing the sample vial container 10 in which the second liquid (W) is not accommodated, and one release and combination are required in the process of receiving the second liquid (W). And, in order to introduce the sample into the second space (S2) of the container body 201, another release and combination are required, and in order to smear the preserved sample, another release and combination is required to take out the sample. I can. The specimen vial container 10 according to the present embodiment may be reversibly coupled and easily coupled and released by adopting a screw connection as a connection between the cap 101 and the container body 201.

Further, the first thread 121s and the second thread 221s may be configured to be screwed at a predetermined angle. When the first thread 121s and the second thread 221s are fully screwed, the screwing angle is about 270 degrees or more, or about 280 degrees or more, or about 290 degrees or more, or about 300 degrees or more, or about 310 degrees. It may be combined at an angle of about 320 degrees or more, or about 330 degrees or more, or about 340 degrees or more, or about 350 degrees or more, or about 360 degrees or more. That is, when the separated cap 101 is disposed on the top of the container body 201 and screwed together, rotation of at least three quarters or more, preferably at least one or more rotations may be possible. In some embodiments, the upper limit of the screw tightening angle when the first thread 121s and the second thread 221s are fully screwed is about 400 degrees, or about 390 degrees, or about 380 degrees, or about 370 degrees, Alternatively, it may be about 360 degrees, but the present invention is not limited thereto.

The support part 251 may protrude upward from the first bottom part 211. The support part 251 may have a bar shape protruding upward from the first bottom part 211. In addition, the support part 251 may be surrounded by the second sidewall part 221 in a plan view. The protruding length of the support part 251 in the third direction Z may be smaller than the protruding length of the second sidewall part 221 in the third direction Z. That is, the upper end of the support part 251 may have a lower height than the upper end of the second sidewall part 221.

One or more support parts 251 may be provided. For example, a total of 4 can be arranged at 90 degree intervals. 3 illustrates a case in which three support parts 251 are represented in a cross-sectional perspective view and a total of four support parts 251 including portions not represented in the cross-sectional perspective view are provided, but the present invention is not limited thereto. In another embodiment, the number of support portions 251 may be one, two, three, or five or more.

The support part 251 may function to form a step relative to the inner surface of the second sidewall part 221 or compared to the upper surface of the first bottom part 211. Through this, during the coupling process between the cap 101 and the container body 201, the lower surface of the filtration unit 301 may be supported in the direction of gravity (eg, the third direction Z).

Next, the filtration unit 301 will be described. The filtering unit 301 may be reversibly coupled to a lower portion of the cap 101, specifically, to a lower portion of the first sidewall portion 131. In a state in which the cap 101 and the filtration unit 301 are coupled, and the cap 101 and the container body 201 are partially or completely coupled, the filtration unit 301 is inserted and disposed within the container body 201. I can. In the filtering unit 301, between the cap 101 and the container body 201, specifically, the first liquid F accommodated in the first space S1 is transferred to the second liquid W side of the second space S2. It can be located on a flowing fluid path. More specifically, when the first liquid (F) is poured into the second liquid (W) by gravity after the sealing sheet 150 is cut, or when the sample vial container 10 is inverted, the second liquid is caused by gravity. When (W) is poured toward the first liquid (F), it may be located on their movement path.

In more detail, the filtration unit 301 may allow a liquid substance to permeate, but not to permeate a sample such as a cell tissue having a predetermined size or more. For example, a cell tissue (not shown) accommodated in the container body 201 may be prevented from moving toward the cap 101. On the other hand, the first liquid F and the second liquid W may pass through the filtration unit 301 and move in opposite directions. In other words, the filtration unit 301 may be a member for preventing backflow of the specimen.

As described above, the specimen (not shown) and the preservative solution are accommodated in the second space S2 together, and the specimen preserved for inspection may be smeared on the slide glass. At this time, since the sample is in the form of a very thin film of tens to hundreds of micrometers, the size is also less than 0.5 cm, and has a transparent color, it may not be easy to collect the sample. At this time, if there is no filtration unit 301, the specimen can move toward the cap 101, and in particular, if the sealing sheet 150 is present in a cut form as described later, the specimen is attached to the sealing sheet 150 or , It may not be easy to collect because it exists on the side of the first space S1. Therefore, by disposing the filtration unit 301, there is an effect that the space in which the specimen can exist can be specified in a relatively small size.

Unlike shown in the drawings, in some embodiments, the volume of the space formed by the second space S2 below the filtration unit 301, that is, from the lower surface of the filtration unit 301 to the upper surface of the first bottom part 211, is , It may be less than or equal to the volume of the mixed solution of the first liquid (F) and the second liquid (W). Through this, it is possible to prevent a phenomenon such as a preservation solution containing formaldehyde, that is, a mixture of the first liquid (F) and the second liquid (W), preventing the sample from being preserved and drying the sample. In some preferred embodiments, the volume of the second space S2 under the filtration unit 301 may be smaller than the volume of the first liquid F, that is, the formaldehyde solution.

Meanwhile, in an exemplary embodiment, in an exemplary embodiment, the concentration of formaldehyde in the mixture of the first liquid F and the second liquid W is about 6.0% (v/v) to 15.0% (v/v). ), or about 7.0% (v/v) to 14.0% (v/v), or about 8.0% (v/v) to 13.0% (v/v), or about 8.0% (v/v) to 12.0% may be (v/v).

As described above, by preparing formalin having a relatively high concentration as the first liquid F, the volume of formalin sealed in the cap 101 can be reduced. Although the present invention is not limited thereto, for example, when the second liquid (W) is injected and prepared by an operator, the sample vial container 10 containing only the first liquid (F) will be considerably lighter in weight. I can. Therefore, there is an advantage that it is possible to transport and transport more specimen vial containers 10 at once. Particularly, when classified as a dangerous material such as formalin, restrictions may occur in handling, transportation, and storage, and minimizing the volume and weight of formalin can serve as an advantage.

In addition, in the process of preparing or preparing a preservative solution having an appropriate component and an appropriate concentration to be suitable for cell fixation, a manufacturer of a sample vial container, a clinician, or a pathologist may be continuously exposed to formalin. In the sample vial container 10 according to the present embodiment, the first liquid (F) having a high concentration of formaldehyde containing harmful components remains sealed, but the second liquid ( W) By allowing the operator to handle only the operator, there is an effect that can greatly reduce the frequency and time of exposure to formaldehyde.

Specifically, the filtration unit 301 includes a second bottom part 311 (or filtration bottom part) in which a plurality of openings 311h are formed, and a third side wall part 331 protruding upward from the second bottom part 311 ( Alternatively, a filtration sidewall portion) may be included, and a stepped portion 351 positioned inside the third sidewall portion 331 may be further included. The second bottom part 311, the third side wall part 331, and/or the stepped part 351 may be integrally formed without a physical boundary with each other. The second bottom part 311, the third side wall part 331, and the step part 351 of the filtering unit 301 may be made of synthetic resin or the like. For example, the filtration unit 301 may be made of a material having a lower rigidity than the cap 101 and/or the container body 201. For a specific example, the filtration unit 301 may be made of a material having elasticity compared to the fastening body portion 121 of the cap 101 and/or the container body 201 as a whole.

The second bottom part 311 may be substantially circular in plan view. The second bottom part 311 may have a plurality of openings 311h. The openings 311h may have a regular matrix arrangement along the first direction X and the second direction Y, or may have a circular arrangement based on an arbitrary center, or may be irregularly arranged. In another embodiment, the opening 311h may be implemented in the form of a radially arranged slit. The second bottom part 311 in which the opening 311h is formed may function as a filtering plate or a filtering plate. The size of the opening 311h may be appropriately selected in consideration of the size of the specimen. For example, the length of the opening 311h in the first direction X (or the second direction Y) is about 10 mm or less, or about 5 mm or less, or about 4 mm or less, or about 3 mm or less, or about 2 mm Or less, or about 1 mm or less, or about 0.5 mm or less.

In an exemplary embodiment, the second bottom part 311 may not have an opening 311h formed, and may have an approximately'+' shaped stem part located in the center. The center of the stem portion may coincide with the center of the circular second bottom portion 311. In other words, the opening 311h may not be located in the stem portion that crosses the second bottom portion 311 in the first direction X and the second direction Y. The plurality of openings 311h through the stem may be divided into approximately four regions. For example, although the present invention is not limited thereto, a plurality of regions may be formed only by the arrangement of the openings 311h without including a separate partition member or the like in which the filtering unit 301 protrudes upward. The stem portion will be described later in detail together with other embodiments.

As described above, when the sealing sheet 150 is cut, the first liquid F in the first space S1 may move toward the second space S2 through the opening 311h. At this time, since the volume of the inside of the sample vial container 10, that is, the volume of the first space S1 and the second space S2 is not large, the first space S1 and the second space S2 are instantaneously During fluid communication, the internal pressure inside the sample vial container 10 may increase. This may be because the first liquid F is poured into the lower side (the second space S2 side), while the air in the lower side (the second space S2) moves upward. When the internal pressure rises severely, harmful liquid including formaldehyde may leak in the form of bubbles through the bonding site of the cap 101 and the container body 201. This problem may not be a problem because a complete sealing is possible when the coupling between the cap 101 and the container body 201 is an irreversible coupling, but the coupling between the cap 101 and the container body 201 as in this embodiment is not This can be a problem if it is a reversible coupling. Therefore, it is necessary to suppress the increase in the internal pressure of the sample vial container 10 as much as possible.

Specifically, the degree to which the first liquid F is poured may affect an increase in the internal pressure of the container. The inventors of the present invention compared to the case where the openings 311h forming the movement path of the first liquid F and/or the second liquid W are arranged completely regularly and are arranged without division of regions, as in the present embodiment. In the case of partitioning a plurality of regions, the present invention has been completed, focusing on the fact that the increase in internal pressure is less. That is, it is difficult to completely and uniformly control the degree of pouring of the first liquid (F) over the entire area. Therefore, the container is divided into four areas, and the liquid is approximately uniformly poured within at least one area. It is possible to reduce the increase in internal pressure. Although the present invention is not limited thereto, some of the four regions intensively contribute to the pouring of the first liquid F, and the degree of pouring of the first liquid F into at least one region may be very small. . This may be because air mainly moves upward in the one area.

The third sidewall portion 331 may protrude upward from the second bottom portion 311. The third sidewall portion 331 may have a substantially open cylindrical shape. The outer diameter of the third side wall portion 331 is smaller than the inner diameter of the fastening body portion 121, and the inner diameter of the third side wall portion 331 is slightly smaller than the outer diameter of the first side wall portion 131, or substantially the same Or it can be finely large. That is, the inner surface of the third side wall portion 331 may be engaged with the flat outer surface of the first side wall portion 131 to form an force-fitting coupling that maintains the coupled state by frictional force. Unlike shown in the drawings, the inner surface of the third side wall portion 331 and the outer surface of the first side wall portion 131 may be configured to form a clip coupling. That is, the inner surface of the third side wall portion 331 and the outer surface of the first side wall portion 131 may be provided with means (eg, clips, grooves, trenches, etc.) capable of engaging with clips. The clip coupling is the same in that it is fitted by applying an up-and-down pressure in the third direction (Z) as in the force-fitting coupling, but the insertion depth in the third direction (Z) is not adjusted and the cap 101 and the filtration unit ( There is a difference in that the positional relationship between 301) in the third direction Z is fixed.

The stepped portion 351 is located inside the third sidewall portion 331 and may have a relatively low height. The stepped portion 351 may have an approximately annular shape in a plan view. For example, the stepped portion 351 may have an upper surface height higher than that of the second bottom portion 311, but may have a lower upper surface height than the upper end (or upper surface) of the third sidewall portion 331. The stepped portion 351 may be configured to come into contact with the first sidewall portion 131.

In some embodiments, the inner surface of the third sidewall portion 331 may be in a flat state without having a thread or the like. This is meant to include the case provided with the clip engaging means. Through this, it is possible to form a force-fitting coupling (or fitting coupling, or clip coupling) between the first side wall portion 131 of the cap 101 and the third side wall portion 331 of the filtering unit 301. In addition, through the combination of the cap 101 and the filtration unit 301, when a separate external force is not applied, when the user rotates the cap 101, the filtration unit 301 also maintains a coupled state with the cap 101. It can be integrated and rotated at least partially together.

Meanwhile, the coupling between the cap 101 and the filtering unit 301 may be a rotation non-limiting coupling. That is, for example, in a state in which only the cap 101 and the filtration unit 301 are combined without other components, the filtration unit 301 is based on the cap 101 (or the cap 101 is based on the filtration unit 301). 2) The cap 101 and the filtering unit 301 may not be separated from each other even if they rotate about 90 degrees or more, or about 180 degrees or more, or about 270 degrees or more on a plane. In addition, in a state in which the cap 101 and the filtration unit 301 are coupled, the angle of rotation of the cap 101 and the filtration unit 301 in a plane may be unlimited at an angle of 360 degrees or more.

When the cap 101 and the filtration unit 301 are forcibly fitted together, the cap 101 and the filtration unit 301 may form a coupling capable of being inserted in the third direction Z. For example, the cap 101 and the filtering unit 301 may be configured to be insertable in the third direction Z without rotation. That is, the degree of insertion of the cap 101 and the filtering unit 301 may be adjusted. In other words, even when the cap 101 is relatively slightly inserted into the filtration unit 301, the cap 101 and the filtration unit 301 form a bonding relationship, and the cap 101 is relative to the filtration unit 301. Even when a lot of insertion is made, the cap 101 and the filtering unit 301 may form a coupling relationship.

Through this, the insertion depth of the cap 101 into the filtration unit 301 can be adjusted only by applying an external force in the third direction Z. In some embodiments, the protruding length of the third sidewall portion 331 in the third direction Z is smaller than the protruding length of the first sidewall portion 131 in the third direction Z, and the first sidewall portion ( When 131 is completely inserted into the filtration unit 301, the lower end of the first side wall portion 131 may abut the upper surface of the stepped portion 351.

Hereinafter, the structure, bonding relationship, arrangement relationship, function, action, and effect of the specimen vial container 10 according to the present embodiment will be described in more detail with reference to FIGS. 5 to 8. 5 to 8 are views for explaining a process and an effect of using the sample vial container 10 of FIG. 1.

Specifically, FIG. 5 is a cross-sectional view showing an initial state of the specimen vial container 10, and FIG. 6 is a cross-sectional view illustrating a state in which the specimen SP is inserted into the specimen vial container 10. 7 is a cross-sectional view showing a state in which the specimen SP is sealed, and FIG. 8 is a cross-sectional view showing a state in which the sealing sheet 150 is cut away.

5 to 8, the lower surface of the filtration unit 301, that is, the opening in the second bottom 311 is not expressed, but this is only an expression of the stem located in the center of the filtration unit 301, the filtration unit 301 ), it will be clear to those skilled in the art that the opening 311h is still formed. Likewise, in FIGS. 5 to 8, the wing portion of the incision portion 171 is not expressed, but this is only an expression of a rod located at the center of the incision portion 171, and the incision portion 171 includes a wing portion. Technicians will be able to understand clearly.

First, referring to FIG. 5 further, the filtration unit 301 is coupled to the lower end of the cap 101, and the first thread 121s of the cap 101 and the second thread 221s of the container body 201 are used. Thus, the cap 101 and the container body 201 are prepared in a combined state. As described above, the first side wall portion 131 of the cap 101 and the third side wall portion 331 of the filtering unit 301 are engaged with each other and are forcibly fitted, and the cap 101 and the container body 201 are screwed Can be tightened and combined. The first screw thread 121s and the second screw thread 221s are completely coupled, and the second liquid W may be kept sealed.

In this embodiment, the lower surface of the second bottom part 311 of the filtering unit 301 may be in a state in contact with the upper surface of the support part 251 of the container body 201. Through this, it is possible to prevent the filtration unit 301 from being separated from the cap 101 during the process of transporting and storing the sample vial container 10. In addition, unlike shown in the drawings, the lower end of the first sidewall portion 131 of the cap 101 may abut the upper surface of the stepped portion 351 of the filtering unit 301.

In addition, the second space (S2) of the container body 201 is in a state in which the first liquid F containing formaldehyde (i.e., a preservative) is accommodated in the first space S1, and is sealed by the cap 101 There may be a state in which the second liquid W (eg, physiological saline) containing sodium chloride is accommodated.

The length of the cut-out part 171 in the third direction Z may be selected in consideration of a distance in the third direction Z from the pressing part 111p to the sealing sheet 150. That is, in a state in which pressure is not applied to the pressing part 111p, the lower end of the cutout part 171 may be in a state spaced apart from the upper surface of the sealing sheet 150. On the other hand, when pressure is applied to the pressing part 111p, the lower end of the cut-out part 171 cuts the sealing sheet 150 from the top to the bottom, and the cut-out part 171 is lower than the first side wall part 131. It may be configured to protrude further.

Next, referring to FIG. 6 further, the cap 101 and the container body 201 are screwed together, and the specimen SP is introduced into the open second space S2 of the container body 201. The specimen SP may be a human cell, tissue, sputum, oral rinse, or the like, but the present invention is not limited thereto. As described above, since the second liquid W is already accommodated in the second space S2, it may be easy to inject the specimen SP using a biopsy forceps or the like.

In this step, the filtering unit 301 may still be in a state of being engaged with the cap 101.

Next, referring to FIG. 7 further, the cap 101 and the container body 201 are combined again. In this step, the coupling may be a screw tightening coupling due to rotation of the first screw thread 121s and the second screw thread 221s. In addition, the specimen SP is accommodated and stored in the second space S2 of the container body 201 sealed by the cap 101 and can be completely isolated from the outside.

Next, referring to FIG. 8 further, the sealing sheet 150 is cut using the cutout 171 by applying pressure to the pressing part 111p. As the sealing sheet 150 is cut, the first space S1 and the second space S2 are in fluid communication, and the first liquid F accommodated in the first space S1 is the opening of the filtration unit 301 It may be poured into the second space S2 through 311h. The first liquid (F) and the second liquid (W) are mixed with each other to form a mixed liquid (FW), and the specimen (SP) may be fixed or preserved by the mixed liquid (FW). The concentration of formaldehyde in the mixed liquid (FW) is about 6.0% (v/v) to 15.0% (v/v), or about 7.0% (v/v) to 14.0% (v/v), or about 8.0% ( v/v) to 13.0% (v/v), or about 8.0% (v/v) to 12.0% (v/v).

The sample vial container 10 according to the present embodiment accommodates different liquids in the first space S1 and the second space S2 separated from each other, so that the time and frequency of exposure to harmful substances such as formaldehyde Can be minimized.

Hereinafter, another embodiment of the present invention will be described. However, descriptions of components that are the same, substantially the same, or extremely similar to the sample vial container according to FIG. 1 described above and that can be understood by those of ordinary skill in the art are omitted, which is from the accompanying drawings. It will be clearly understood.

9 is a perspective view of a sample vial container 30 according to another embodiment of the present invention. 10 is an exploded perspective view of the specimen vial container 30 of FIG. 9. 11 is a cross-sectional perspective view of the specimen vial container 30 of FIG. 10. 12 is a rear perspective view of the cutting unit 190 of FIG. 11. 13 is a perspective view of the filtering unit 303 of FIG. 11.

9 to 13, the specimen vial container 30 according to the present embodiment has a thread formed on the outside of the cap 103, and a thread is formed on the inside of the container body 203, as shown in FIG. This is different from the sample vial container 10 according to the example. The sample vial container 30 may be a container for performing a biopsy or a liquid cell test, but the present invention is not limited thereto.

The cap 103 may have a sealed first space S1. A liquid substance, for example, the first liquid F may be accommodated in the first space S1. Since the first liquid F has been described above, a redundant description will be omitted.

Specifically, the cap 103 protrudes downward from the ceiling portion 113 at the top, the pressing portion 113p located inside the ceiling portion 113, and the ceiling portion 113, and a first thread 123s (or cap Including a first side wall portion 123 (or a cap side wall portion) having a thread) and a sealing sheet 150 disposed below the first side wall portion 123, and a cutting unit disposed in the first space S1 ( 190) may be further included. In addition, the first sidewall portion 123 may include a first vertical portion 123a positioned at an upper side, a second vertical portion 123b positioned at a lower side, and a horizontal portion 123c positioned therebetween.

The ceiling part 113 and the first side wall part 123 may be integrally formed without a physical boundary with each other. Furthermore, the ceiling portion 113 and the pressing portion 113p may also be integrally formed without a physical boundary with each other. In some embodiments, the cutting unit 190 may be accommodated in the first space S1 sealed by the sealing sheet 150 without direct coupling with other components. The ceiling portion 113 has a substantially annular shape with an open center in a plan view, and the pressing portion 113p may be disposed at an inner edge of the annular ceiling portion 113. The pressing part 113p may be formed to protrude upward and may be configured to be deformed or moved in an up-down direction (eg, the third direction Z). Since the material, thickness, and other descriptions of the ceiling portion 113 and the pressing portion 113p are the same as those described above, duplicate descriptions are omitted.

The first sidewall part 123 is a first vertical part 123a (or upper vertical part) located on the upper side, a second vertical part 123b (or lower vertical part) located on the lower side, and a horizontal part 123c located therebetween. ) Can be included. Each of the first vertical portion 123a and the second vertical portion 123b may have a substantially cylindrical shape. In addition, the protruding length of the first vertical portion 123a in the third direction Z may be greater than the protruding length of the second vertical portion 123b in the third direction Z. In a state in which the cap 103 and the container body 203 are partially or completely coupled, the first vertical part 123a and the horizontal part 123c are located outside the container body 203, and the second vertical part 123b ) May be inserted into the container body 203. That is, the outer diameter of the second vertical portion 123b may be smaller than the inner diameter of the container body 203 to be described later.

The first side wall portion 123 may be provided with a means capable of being reversibly coupled to the container body 203 on its outer circumferential surface. For example, the coupling means may be a first thread 123s (or a cap thread).

The first vertical portion 123a and the second vertical portion 123b may form a first space S1 together. The outer and/or inner surfaces of the first vertical portion 123a and the second vertical portion 123b may extend in the third direction Z, but the present invention is not limited thereto. In some embodiments, a width or width formed by the cylindrical first vertical portion 123a and the cylindrical second vertical portion 123b may be different from each other. For example, the inner diameter of the second vertical portion 123b may be larger than the inner diameter of the first vertical portion 123a, but the present invention is not limited thereto. Further, the outer surface of the lower end of the second vertical portion 123b may have a partially recessed groove.

The first vertical portion 123a is a portion mainly gripped by a user, and the second vertical portion 123b is inserted into the container body 203 and may be a portion in which a first thread 123s for coupling is formed. In some embodiments, the lower end of the second vertical portion 123b may form a rotational non-limiting coupling with the filtering unit 303. That is, the first thread 123s may not contribute to the coupling between the filtration unit 303 and the cap 103.

The horizontal portion 123c is located between the first vertical portion 123a and the second vertical portion 123b, and in a plane direction (eg, a first direction (X), a second direction (Y), or a first direction). It may have a shape extending in the plane direction (X) and the second direction (Y) belong. When the horizontal portion 123c has a substantially annular shape in a plan view, the maximum outer diameter of the horizontal portion 123c may be larger than the outer diameters of the first vertical portion 123a and the second vertical portion 123b. The horizontal part 123c may perform a cap function to seal the upper end of the container body 203 to be described later.

The sealing sheet 150 may have an approximately circular shape. The sealing sheet 150 may be disposed or adhered to the lower end of the first sidewall portion 123, specifically, the lower end of the second vertical portion 123b to form a sealed first space S1. Specifically, the lower surface of the pressing part 113p, the lower surface of the ceiling part 113, the inner surface of the first side wall part 123, and the upper surface of the sealing sheet 150 may form a first space S1 together. Since the sealing sheet 150 has been described above, a duplicate description will be omitted.

The cutting unit 190 may be disposed in the first space S1. The cutting unit 190 may not be directly coupled to other components and may be freely accommodated in the first space S1, but the present invention is not limited thereto.

The cutting unit 190 includes a rod portion 191 extending in the third direction (Z), a first wing portion 195 extending in a substantially'+' direction from the upper end of the rod portion 191, and the lower end of the rod portion 191 The second wing portion 192 extending in the direction of the'+' shape from, is located under the second wing portion 192 and is located under the incision 193 having a sawtooth shape and the second wing portion 192 It may include an incision support portion 194 having an approximately'ㅁ' shape.

The first wing part 195 may be located in a space surrounded by the first vertical part 123a of the first side wall part 123. That is, the first wing portion 195 may approximately maintain or fix the horizontal position of the cutting unit 190 by using the interference between the horizontal end of the first wing portion 195 and the first vertical portion 123a. I can. In addition, when the pressing portion 113p moves downward or is deformed downward, it may be easily transmitted to the cutting unit 190 so that the pressure applied to the pressing portion 113p comes into contact with the pressing portion 113p. . Likewise, the second wing part 192 may be located in a space surrounded by the second vertical part 123b of the first side wall part 123. In addition, the second wing portion 192 may approximately maintain or fix the horizontal position of the cutting unit 190 by using the interference between the horizontal end portion of the second wing portion 192 and the second vertical portion 123b. I can.

A cutout 193 having a serrated tip may be disposed at the lower end of the cutout unit 190. The cutout 193 may be a part that directly contributes to the cutout of the sealing sheet 150. The cutout 193 overlaps the second wing part 192 in the third direction Z, and may have substantially the same or similar planar shape. The cutout support 194 may have a horizontal support shape connecting each end of the cutout 193 to each other.

Next, the container body 203 will be described. The container body 203 may have a second space S2 that can be opened or sealed. The second liquid W may be accommodated in the second space S2. Since the second liquid W has been described above, a duplicate description will be omitted. In addition, the second space S2 may provide a space in which a sample such as cells, tissues, and cell tissues collected from a subject is accommodated when the sample vial container 30 is used. That is, the second liquid W may be located in a space in which the specimen is accommodated. When the container body 203 and the cap 103 are separated, the second space S2 becomes an open space, but when the container body 203 and the cap 103 form a bond, the second space S2 Can be completely sealed from outside and outside air. The sealing may be achieved through the horizontal portion 123c of the first sidewall portion 123, but the present invention is not limited thereto.

Specifically, the container body 203 protrudes upward from the first bottom part 213 (or container bottom part) and the first bottom part 213 at the bottom, and a second thread 223s (or container thread) on the inner side. ) Is formed and may include a second sidewall portion 223 (or a container sidewall portion) forming a second space S2. The first bottom part 213 and the second side wall part 223 may be integrally formed without a physical boundary with each other. Since the material of the container body 203 has been described above, a duplicate description will be omitted.

The first bottom part 213 may be substantially circular in plan view. The second sidewall portion 223 may protrude upward from the outer peripheral edge of the first bottom portion 213. The second sidewall portion 223 may have a substantially open cylindrical shape. An outer diameter of the second sidewall portion 223 may be larger than an outer diameter of the second vertical portion 123b and an outer diameter of the third sidewall portion 333 to be described later. Accordingly, both the second vertical portion 123b and the third side wall portion 333 may be inserted into the second side wall portion 223. In a state in which the cap 103 and the container body 203 are completely coupled, the upper end of the second side wall portion 223 may abut the lower surface of the horizontal portion 123c.

In an exemplary embodiment, the container body 203 may have a means capable of reversibly engaging the cap 103 described above therein. For example, the coupling means may be a second thread 223s (or a container thread). Since the tightening angles of the first thread 123s and the second thread 223s have been described above, overlapping descriptions will be omitted.

Next, the filtration unit 303 will be described. The filtering unit 303 may be reversibly coupled to a lower portion of the cap 103, specifically to a lower portion of the second vertical portion 123b of the first sidewall portion 123. In a state in which the cap 103 and the filtration unit 303 are coupled, and the cap 103 and the container body 203 are partially or fully engaged, the filtration unit 303 is inserted and disposed within the container body 203. I can.

Specifically, the filtration unit 303 includes a second bottom (or filtration bottom) having a plurality of openings 313h and a third sidewall 333 protruding upward from the second bottom 313 (or filtration Sidewall portion), and may further include a protrusion 353 positioned inside the third sidewall portion 333. The second bottom portion 313, the third sidewall portion 333, and/or the protrusion portion 353 may be integrally formed without a physical boundary with each other. Since the material of the filtration unit 303 has been described above, a duplicate description will be omitted.

The second bottom portion 313 may be substantially circular in plan view. The second bottom portion 313 may have a plurality of openings 313h. The openings 313h may be regularly arranged in a matrix along the first direction X and the second direction Y. In an exemplary embodiment, the second bottom portion 313 may not have an opening 313h formed and may have a stem portion 313p having an approximately “+” shape located at the center. The center of the stem portion 313p may coincide with the center of the circular second bottom portion 313. The plurality of openings 313h through the stem portion 313p may be divided into approximately four regions. The stem portion 313p includes a first portion extending in the first direction X and a second portion extending in the second direction Y, the width of the first portion in the second direction Y, and The width of the second portion in the first direction (X) is about 40% or more, or about 50% or more of the length of the opening 313h in the first direction (X) (or the second direction (Y)) , Or about 60% or more. Through this, it is possible to divide the plurality of openings 313h into four regions, thereby exhibiting an effect of suppressing an increase in internal pressure of the container.

The third sidewall portion 333 may protrude upward from the second bottom portion 313. The third sidewall portion 333 may have a substantially open cylindrical shape. The outer diameter of the third sidewall portion 333 is smaller than the inner diameter of the second sidewall portion 223, and the inner diameter of the third sidewall portion 333 is the minimum of the second vertical portion 123b of the first sidewall portion 123 It may be finely smaller than the outer diameter, or substantially the same, or finely larger than the outer diameter. The minimum outer diameter of the second vertical portion 123b may mean an outer diameter of a portion in which a groove is formed. Accordingly, the inner surface of the third side wall portion 333 may form a force-fitting or clip-fitting coupling with the outer surface of the first side wall portion 123. In some embodiments, the inner surface of the third sidewall portion 333 may be in a flat state. Through this, the cap 103 and the filtration unit 303 may form a rotational non-limiting combination.

Also, the protrusion 353 may be disposed to surround the opening 313h in a plan view. The protrusion 353 may include a first portion extending in the first direction X and a second portion extending in the second direction Y. 13 illustrates a case in which a total of four protrusions 353 are disposed including a hidden portion. Both ends of the two first portions in the first direction (X) and both ends of the two second portions in the second direction (Y) may each contact the inner surface of the third sidewall portion 333. Through this, from a plan view, the cutting unit 190 can be completely divided into an area surrounded by the protrusion 353 and an area outside the protrusion 353. Meanwhile, the protrusion height of the protrusion 353 in the third direction Z may be smaller than the protrusion height of the third sidewall 333 in the third direction Z.

In some embodiments, in a state in which the cap 103 and the filtering unit 303 are coupled, the upper end of the protrusion 353 is the lower end of the second vertical portion 123b of the first sidewall portion 123 of the cap 103 And may be spaced apart in the third direction (Z).

That is, the second vertical portion 123b having a circular shape in the plan view and the protruding portion 353 having a substantially rectangular shape in the plan view partially overlap in the third direction Z (overlap in the plan view), but the second vertical part The 123b and the protrusion 353 may be spaced apart in the third direction Z to have a space therebetween. In addition, fluid communication, particularly air, may be communicated between the inner region and the outer region of the protrusion 353 through the space. This can exhibit the effect of suppressing the increase in the internal pressure of the container.

On the other hand, the opening 313h is located only in the inner space surrounded by the protrusion 353, and the opening 313h may not be formed in the four arcuate regions outside the protrusion 353. This can exhibit an effect of suppressing an increase in the internal pressure of the container at the moment when the first liquid F is poured.

Hereinafter, the structure, bonding relationship, arrangement relationship, function, action, and effect of the specimen vial container 30 according to the present embodiment will be described in more detail with reference to FIGS. 14 to 17. 14 to 17 are views for explaining a process and an effect of using the sample vial container 30 of FIG. 9.

Specifically, FIG. 14 is a cross-sectional view showing an initial state of the specimen vial container 30, and FIG. 15 is a cross-sectional view illustrating a state in which the specimen SP is inserted into the specimen vial container 30. 16 is a sectional view showing a state in which the specimen SP is sealed, and FIG. 17 is a sectional view showing a state in which the sealing sheet 150 is cut away.

In FIGS. 14 to 17, the lower surface of the filtration unit 303, that is, the opening in the second bottom 313 is not expressed, but this is only an expression of the stem located at the center of the filtration unit 303, and the filtration unit 303 ), it will be clearly understood by those skilled in the art that the opening 313h is still formed.

First, referring to FIG. 14 further, the filtration unit 303 is coupled to the lower end of the cap 103, and the first thread 123s of the cap 103 and the second thread 223s of the container body 203 are used. Thus, the cap 103 and the container body 203 are prepared in a combined state. As described above, the first side wall portion 123 of the cap 103 and the third side wall portion 333 of the filtering unit 303 are engaged with each other and are forcibly fitted, and the cap 103 and the container body 203 are screwed. Can be tightened and combined. The first thread 123s and the second thread 223s are completely coupled, and the second liquid W may have a sealed state.

The first liquid F containing formaldehyde (i.e., a preservative) is accommodated in the first space S1, and sodium chloride is in the second space S2 of the container body 203 sealed by the cap 103. A second liquid W (eg, physiological saline) containing a may be accommodated.

The length of the cutting unit 190 in the third direction Z may be selected in consideration of a distance in the third direction Z from the pressing portion 113p to the sealing sheet 150. That is, in a state in which pressure is not applied to the pressing portion 113p, the length of the cutting unit 190 in the third direction Z may be smaller than the distance between the pressing portion 113p and the sealing sheet 150 . On the other hand, when pressure is applied to the pressing part 113p and deformed downward, the length of the cutting unit 190 in the third direction Z is greater than the distance between the pressing part 113p and the sealing sheet 150, Accordingly, the cutout 193 may cut the sealing sheet 150 from the top to the bottom, and the cutout unit 190 may protrude outside the first space S1.

In an exemplary embodiment, the protrusion 353 of the filtration unit 303 is spaced apart from the lower end of the first side wall part 123 and the lower surface of the sealing sheet 150 in the third direction (Z), and therebetween It is as described above that a movement path may be provided.

Next, referring to FIG. 15 further, the cap 103 and the container body 203 are screwed together, and the specimen SP is introduced into the open second space S2 of the container body 203. At this stage, the filtration unit 303 may still be in a state of being engaged with the cap 103.

Next, referring to FIG. 16 further, the cap 103 and the container body 203 are combined again. In this step, the coupling may be a screw tightening coupling due to rotation of the first screw thread 123s and the second screw thread 223s. In addition, the specimen SP is accommodated and stored in the second space S2 of the container body 203 sealed by the cap 103 and can be completely isolated from the outside.

Next, referring to FIG. 17 further, the cutting unit 190 is moved by applying pressure to the pressing part 113p and the sealing sheet 150 is cut. As the sealing sheet 150 is cut, the first space S1 and the second space S2 are in fluid communication, and the first liquid F accommodated in the first space S1 is the opening of the filtration unit 303 It may be poured into the second space S2 through 313h. And the first liquid (F) and the second liquid (W) are mixed with each other to form a mixed solution (FW), and the sample (SP) may be fixed or stored by the mixed solution (FW). Since the mixed liquid FW has been described above, a duplicate description will be omitted.

The embodiments of the present invention have been described above, but these are only examples and do not limit the present invention, and those of ordinary skill in the field to which the present invention pertains should not depart from the essential characteristics of the embodiments of the present invention. It will be appreciated that various modifications and applications not illustrated above are possible.

Therefore, the scope of the present invention should be understood to include modifications, equivalents, or substitutes of the technical idea exemplified above. For example, each component specifically shown in the embodiment of the present invention may be modified and implemented. And differences related to these modifications and applications should be construed as being included in the scope of the present invention defined in the appended claims.

10: sample vial container
101: cap
111: ceiling
111p: pusher
121: fastening body portion
121s: cap thread
131: cap side wall portion
150: sealing sheet
171: incision
201: container body
211: container bottom
221: container side wall portion
221s: vessel thread
251: support
301: filtration unit
311: filter bottom
311h: opening
331: filtration side wall portion
351: step portion
F: first liquid
W: second liquid
SP: specimen
S1: first space
S2: second space

Claims (2)

A cap containing the first liquid accommodated in the first space sealed by the sealing sheet; A container body configured to be coupled to a lower end of the cap and providing a second space in which a second liquid is accommodated; And a filtration unit coupled to a lower end of the cap and inserted into the container body,
The filtering unit includes: a bottom portion having an opening, a sidewall portion protruding upward in a cylindrical shape from an edge of the bottom portion, a first projection portion protruding upward from the bottom portion and extending in a first direction, and abutting the inner surface of the sidewall portion , And a second protrusion protruding upward from the bottom part, extending in a second direction crossing the first direction, and contacting an inner surface of the side wall part,
The opening of the bottom portion is located only inside the space surrounded by the first and second projections, and when the upper end of the cap is pressed, a cutout in the first space moves downward to cut the sealing sheet,
The first liquid is a liquid substance containing formaldehyde, and the second liquid is a liquid substance containing no formaldehyde or having a lower concentration of formaldehyde than the first liquid. delete

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