KR102011451B1 - Composition for promoting health of eyes - Google Patents

Abstract

The present invention relates to a composition containing the ginseng fruit extract as an active ingredient, and improves the symptoms of eye fatigue, pressure, dryness, pain, tickling and the like to provide an overall health promotion effect of the eye.

Description

Composition for promoting health of eyes}

The content described herein relates to the novel use of ginseng fruit for human health.

Ginseng (Panax ginseng CA Meyer) is a plant belonging to the genus Ogapiaceae ginseng, which has been used for more than 2,000 years in Korea, China, Japan, etc., and has been used to prevent disease and prolong life. The effects and effects of ginseng on the central nervous system, anti-carcinogenic, anti-cancer, immune-modulatory, anti-diabetic, hepatic anti-inflammatory effect, cardiovascular disorders, anti-arteriosclerosis, blood pressure control, menopausal disorders , Effects on osteoporosis, antistress action, anti-fatigue, antioxidant activity, anti-aging effects are known (latest ginseng "components and potency", Korea Ginseng and Tobacco Research Institute, 56-112, 1996).

Ginsenoside, a representative physiologically active ingredient of ginseng, is distributed evenly on the ground and underground parts of ginseng.Ginsenoside content and composition are different depending on the parts such as ginseng root (root), ginseng leaf, and ginseng fruit. Known (Attele AS et al, Biochem Pharmacol, 58; 1685-1693, 1999).

However, studies on the specific ingredients and eye health contained in ginseng fruit are insufficient.

Domestic Publication No. 10-2008-0094540

Attele AS et al, Biochem Pharmacol, 58; 1685-1693, 1999 Dey L. et al., Phytomedicine, 10; 600-605, 2003 Nat. Prod. REP., 2009, 26, 1001-1043 Asia Pac J Clin Nutr. 2007; 16 (2): 200-208

The present invention as a composition comprising ginseng fruit having a novel use for human health, to provide a composition for improving overall eye health.

In order to achieve the above object, one embodiment of the present invention provides a composition for promoting eye health containing ginseng fruit extract as an active ingredient.

In addition, an embodiment of the present invention is to provide a composition for improving eye fatigue including ginseng fruit extract.

The composition according to the present invention is excellent in the effect of promoting eye health by containing ginseng fruit extract, it can effectively improve the eye fatigue.

In addition to improving the health of the eyes, it can improve the overall health of the human body, such as improving fatigue, providing mental stability, improving skin condition, improving numbness of the hands and feet, and relieving menopausal symptoms.

Therefore, the composition according to the present invention can be variously used in the food and medicine fields.

1 is a graph showing the results of analyzing ginsenoside components of ginseng fruit extract and ginseng root extract according to an embodiment of the present invention.
Figure 2 is a graph showing the results of evaluating the overall eye health improvement of ginseng fruit extract according to an embodiment of the present invention.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

One embodiment of the present invention provides a composition for promoting eye health containing ginseng fruit extract as an active ingredient.

Ginseng fruit is different from the ginseng root (root) commonly used as a part of ginseng, the type and content of the components contained.

Specifically, ginseng fruit contains more mineral components including vitamins than ginseng root. In addition, the ginseng fruit contains more ginsenosides than the ginseng root, and the composition of the ginsenosides contained is different. In one embodiment of the present invention ginseng fruit extract ginsenoside PT (Protopanaxatriol) system comprising ginsenosides Re, Rg1, Rg2, etc. It may contain more than PD (Protopanaxadiol) system, and thus may exhibit different effects. Ginseng fruit, for example, has been reported to show better antidiabetic efficacy than ginseng root (Dey L. et al., Phytomedicine, 10; 600-605, 2003).

In addition, as the ginseng fruit is ripened in green such as leaves, the flesh changes to red or yellow depending on the variety. Thus, as the color of the flesh changes, anthocyanin is formed in the ginseng fruit. Anthocyanins include, for example, cyanidin chloride, delphinidin chloride, malvidin chloride, pelargonin chloride, cyanin chloride, idea chloride ), Keracyanin chloride, kuromanin chloride, pelagonidin chloride, petunidin chloride, etc. (Nat. Prod. REP., 2009, 26, 1001-1043). And anthocyanin is effective for antioxidant, anti-allergic, anti-inflammatory, anti-viral, anti-proliferative, anti-mutant, antibacterial, anti-carcinogenic, cardiovascular damage and allergy protection, microcirculation protection, peripheral capillary resistance protection, diabetes improvement (Asia Pac J Clin Nutr. 2007; 16 (2): 200-8).

Therefore, the composition according to an embodiment of the present invention may contain vitamins, minerals, ginsenosides, anthocyanins, and the like, which are rich in ginseng fruit extracts, thereby improving eye health by improving eye fatigue and dryness. Can be promoted.

Anthocyanins are able to bind rhodopsin, a red light-sensing protein contained in rod-shaped rod cells in the retina of the eye, and the phototransduction process of phosphodiesterase (PDE) May improve night vision and improve eye health (Asia Pac J Clin Nutr 2007; 16 (2): 200-208).

In addition, the ginseng fruit extract according to an embodiment of the present invention

(a) pretreatment of ginseng fruit; and

(b) extracting the ginseng fruit pretreated in the step with water or an organic solvent to obtain a ginseng fruit extract; can be prepared by.

In step (a), the ginseng fruit may be raw ginseng fruit, and the pulp and skin of the ginseng fruit may be dried through daylight drying or hot air drying.

In addition, the ginseng fruit extract in step (b) may be prepared by extracting the dried ginseng fruit under reflux at room temperature using water or an organic solvent, and then concentrated under reduced pressure.

The composition according to an embodiment of the present invention may contain 0.01 to 100% by weight of the ginseng fruit extract, based on the composition.

In addition, the composition according to another embodiment of the present invention may be formulated as a pharmaceutical composition or a food composition in the form of tablets, pills, tablets, capsules, granules, powders, ointments, drinks or injections.

The present invention provides a pharmaceutical composition containing ginseng fruit extract according to a conventional method as an embodiment. In the preparation of pharmaceutical formulations, it is preferred to mix or dilute the active ingredient with the carrier or to enclose it in a carrier in the form of a container. When the carrier is used as a diluent, it may be a solid, semisolid or liquid substance which acts as a carrier, excipient or medium for the active ingredient. Thus, the formulation may be in the form of tablets, pills, powders, sachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols, soft or hard gelatin capsules, sterile injectables, sterile powders and the like.

Examples of suitable carriers, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propyl Hydroxybenzoate, talc, magnesium stearate and mineral oil. The formulation may further comprise fillers, anti-coagulants, lubricants, wetting agents, fragrances, emulsifiers, preservatives and the like. Compositions of the present invention may be formulated using methods well known in the art to provide rapid, sustained or delayed release of the active ingredient after administration to a mammal.

The pharmaceutical composition of the present invention may be administered through several routes including oral, transdermal, subcutaneous, intravenous, abdominal, muscle, topical application, patch and iontophoresis, of which topical application and oral administration are preferred. Do.

In humans, a typical daily dosage of the active compound may range from 1 to 100 mg / kg body weight, preferably 5 to 70 mg / kg body weight, and may be administered once or in several doses. However, it should be understood that the actual dosage of the active ingredient should be determined in light of several relevant factors such as the disease to be treated, the route of administration, the age, sex and weight of the patient, and the severity of the disease, and therefore the dosage may be determined in any way. Nor does it limit the scope of the present invention.

In addition, the present invention provides a food composition containing a ginseng fruit extract according to a conventional method as an embodiment.

The food composition of the present invention has a formulation in a liquid or solid state, and the formulation is not particularly limited, and may be, for example, formulated into tablets, granules, drinks, caramels, diet bars, and the like. In addition to the active ingredient, the food composition of each formulation may be suitably selected by a person skilled in the art according to the formulation or purpose of use in addition to the active ingredient, and may be synergistic when applied simultaneously with other raw materials.

Hereinafter, the present invention will be described through the following examples and test examples. Examples and test examples are intended to explain the present invention in more detail, but the scope of the present invention is not limited to the scope of the following examples.

In addition, it is obvious that any person skilled in the art can make various modifications and imitations within the scope of the appended claims without departing from the scope of the technical idea of the present invention.

Example 1 Preparation of Ginseng Fruit Extract

Ginseng Fruit Pretreatment

Raw ginseng fruit was harvested, seed was separated and removed, and then the ginseng fruit dried raw material was prepared by sun drying or hot air drying.

Ginseng fruit extract manufacturer

Water or alcohol (ethanol) 3L was added to 1 kg of dried ginseng fruit dried and refluxed at room temperature, filtered and concentrated under reduced pressure at 40 ~ 45 ℃ to obtain 300 g of ginseng fruit extract.

Comparative Example 1 Preparation of Ginseng Root Extract

Except for using ginseng root (root) instead of ginseng fruit in Example 1 was prepared in the same manner as in Example 1.

Test Example 1 Component Comparison of Ginseng Fruit Extract

<Analysis of Ginsenoid (Ginseng Saponin) in Ginseng Fruit and Ginseng Root>

After preparing the ginseng fruit of Example 1 and the ginseng root extract of Comparative Example 1 according to an embodiment of the present invention, the extract was treated with ether to remove fat-soluble components and then irradiated with butanol (BuOH) Extracted and concentrated to perform ginsenoid component analysis through HPLC, the results are shown in Figure 1 and Table 1 below.

Example 1 (Ginseng Fruit Extract) Comparative Example 1 (Ginseng Root Extract) Irradiated Ponin Content (Dry Weight) 33.42% 16.70% PD / PT ratio 0.73 3.23

As a result, as shown in Figure 1 and Table 1, the ginseng fruit extract prepared in Example 1 was found to have a content of about 2 times or more than the ginseng root extract prepared in Comparative Example 1 in the content of irradiated.

As for the content ratio, ginsenosides were divided into ratios of PD (Protopanaxadiol) -ginsenosides Rb1, Rb2, Rc and Rd and PT (Protopanaxatriol) -ginsenosides Re, Rg1 and Rg2, respectively, at 0.73 and 3.23. As a result, it was found that the composition and content of ginsenosides contained in ginseng fruit and ginseng root showed opposite characteristics. In addition, the ginseng fruit extract was found to contain about 9 times more particularly ginsenoside Re than ginseng root extract.

Mineral Analysis of Ginseng Fruit Extract

In order to distinguish that the ginseng fruit extract prepared in Example 1 has the characteristics of "fruit" different from ginseng, an analysis of mineral components including vitamins was performed, and the results are shown in Table 2 below.

ingredient Fruit content Root content ingredient Fruit content Root content Potassium (mg / 100g) 5865.57 1460 Magnesium (mg / 100g) 354.38 160 Calcium (mg / 100g) 819.26 340 Zinc (mg / 100g) 178.49 1.961 Iron (mg / 100g) 59.31 9.804 Vit.A (ug / 100g, RE) 213.11 - Phosphorus (mg / 100g) 187.17 340 Vit.B1 (mg / 100g) 12.29 0.16 Vit.B2 (mg / 100g) 8.45 0.50 Vit.B6 (mg / 100g) 10.50 - Vit.C (mg / 100g) 4.91 6 Vit.E (mg / 100g, α-TE) 23.61 - Vit.K (μ / 100g) 232.12 - Niacin (mg / 100g, NE) 5.76 1.0 Pantothenic Acid (mg / 100g) 5.87 0.66 Folic Acid (µg / 100g) 349.97 -

As shown in Table 2, the ginseng fruit according to an embodiment of the present invention was very rich in vitamins and minerals of 16 kinds in general, unlike ginseng root.

As such, the ginseng fruit according to an embodiment of the present invention contains more ginseng saponin than the ginseng root, and at the same time, the nature of the saponin composition is the opposite, and unlike the ginseng root, the content of 16 kinds of vitamins and minerals as fruits This richness could be confirmed.

<Anthocyanin component analysis of ginseng fruit extract>

The anthocyanin component contained in the ginseng fruit extract of Example 1 prepared according to an embodiment of the present invention was quantitatively analyzed.

At this time, the anthocyanidin kit (cyanidin chloride, delphinidin chloride, malvidin chloride, feragonine chloride), cyanidin derivative kit (cyanidin chloride, cyanine chloride, the idea chloride, keratinine chloride, kuromanin chloride Ginseng fruit anthocyanin was quantitatively analyzed using the standard, ferragonidine chloride and petunidine chloride, and the results are shown in Table 3.

Analytical Items Unit: ppm (ug / g) Ginseng Berry Extract Malvidin chloride 12.17 The idea chloride (cyanidin-3-O-galactoside) 2.36 Ferragonidine Chloride 8.28 Keratinine chloride 3.29 Sum 26.1

As a result of the analysis, as shown in Table 3, the amount of malvidin chloride, idea chloride, peronin chloride and keratinine chloride was quantified as 12.17, 2.36, 8.28 and 3.29 ppm, respectively, and the sum of the four components totaled 26.1. Measured in ppm, it was found that anthocyanin is abundantly contained.

 Test Example 2 Evaluation of Eye Health Improvement

Based on the results of Test Example 1, the changes in eye health indicators appearing when a composition containing ginseng fruit extract was used directly in the human body according to an embodiment of the present invention were observed and evaluated. That is, changes in eye health before and after ingestion of ginseng fruit extract were evaluated by the following method.

For the experiment, 700 mg tablets containing 100% by weight of the ginseng fruit extract of Example 1 were prepared. At this time, the tablets were compressed using a table top single tablet press (ERWEKA. Germany).

And for 58 men and women in their 10's and 50's, the tablets containing the ginseng fruit extract were ingested twice daily and twice daily for four weeks. In other words, the standardized ginseng fruit extract was consumed 1400mg per day.

 At the same time, the following survey was conducted on the overall eye health index before and after ingestion.

19 common eye-related discomforts: fatigue, tightness, eyelid fatigue, tear flow, heat, dryness, pain, itchiness, eyelid spasms, afterimages, glare, blinding, congestion, swelling, foreign body, We checked the degree of discomfort (1-15 points) for each symptom of nausea, afternoon fatigue, burning and focusing time. 15 points for very uncomfortable cases and 1 point for no discomfort was checked. Evaluation results are shown in Table 4 and FIG. 2 as a change in the eye health self-diagnosis score before and after ingestion of ginseng fruit extract (N = 58).

Item range Before intake
Mean ± SD After ingestion
Mean ± SD Fatigue 1-15 10.5 ± 1.56 5.4 ± 1.86 Pressure 1-15 8.7 ± 0.22 6.2 ± 0.78 Eyelid Fatigue 1-15 13.5 ± 1.79 4.2 ± 0.71 Tear flow 1-15 11.1 ± 0.26 6.7 ± 0.97 Heat 1-15 9.3 ± 1.61 5.4 ± 1.11 Dryness 1-15 12.8 ± 0.46 4.7 ± 0.85 ache 1-15 5.5 ± 0.12 4.5 ± 0.63 Tickle 1-15 6.7 ± 1.55 3.7 ± 1.36 Blepharopasm 1-15 8 ± 2.01 4.2 ± 0.65 afterimage 1-15 4.5 ± 1.71 2.5 ± 0.99 Glare 1-15 6.1 ± 1.24 3.5 ± 0.76 Snowfall 1-15 9.9 ± 1.23 4.3 ± 1.49 congestion 1-15 11.8 ± 1.75 4.2 ± 1.79 film 1-15 10 ± 1.55 4.5 ± 0.71 Foreign body 1-15 7.8 ± 1.25 4.8 ± 0.75 Snow 1-15 8.2 ± 2.1 4 ± 0.21 Afternoon fatigue 1-15 12.9 ± 1.66 5.1 ± 0.73 Burning 1-15 8.9 ± 2.11 4.3 ± 1.25 Focus time 1-15 9 ± 1.25 5.5 ± 0.78

As shown in Table 4 and FIG. 2, the subjects evaluated that the overall health status of the eyes, including eye fatigue, was improved by 50% or more after ingesting ginseng fruit extract, and the ginseng fruit extract was very effective in promoting eye health. It was found to be effective.

In addition, in addition to the results of Test Example 2, the subjects were able to feel the fatigue and mental stability of not only eyes but also the overall body after ingesting ginseng fruit extract, improved skin condition, disappeared limbs, and menopausal symptoms. Recorded to be relaxed. Thus, ginseng fruit extract was found to be very effective in improving the health of the human body as a whole.

Examples of the formulation of the composition according to an embodiment of the present invention will be described below, but it is also applicable to various other formulations, which are intended to explain in detail only and not intended to limit the present invention.

Formulation Example 1 Extract of Ginseng Fruit 100%

When preparing the ginseng fruit extract of Example 1 was concentrated to 60% or more solids, and aged at low temperature to prepare a 100% extract product in liquid form.

Formulation Example 2 Soft Capsule

110 mg of ginseng fruit extract of Example 1, 0.8 mg of palm oil, 0.48 mg of vegetable hardened oil, 2.4 mg of beeswax and 3.6 mg of lecithin were mixed and filled according to a conventional method to prepare a soft capsule.

Formulation Example 3 Tablet

160 mg of ginseng fruit extract of Example 1, 200 mg of glucose, and 196 mg of dextrin were mixed and granulated using a fluidized bed dryer, and then, 7 mg of sugar ester was added thereto, and tableted with a tablet press to prepare a tablet.

Formulation Example 4 Preparation of Ring

0.9 g of ginseng fruit extract of Example 1, 0.3 g of sugar, 1.91 g of starch, and 0.56 g of glycerin were mixed, and a ring was prepared using a dehydrator.

Production Example 5 Granules

160 mg of ginseng fruit extract of Example 1, 200 mg of glucose, and 196 mg of dextrin were mixed and granulated using a fluidized bed dryer, and then filled into fabrics to prepare granules.

[Manufacture example 6] Drink system

110mg of ginseng fruit extract of Example 1, 10g of glucose and 2g of citric acid were mixed, and then 188g of purified water was added thereto to fill 200ml of each bottle. After filling the bottle and sterilized 2-3 hours at 90 ℃ to prepare a beverage.

Claims (7)

It is a food composition for eye health enhancement containing ginseng fruit extract as an active ingredient,
The ginseng fruit extract is a rhodopsin synthesis or phosphodiesterase light conversion promoter containing anthocyanin,
The improvement of eye health is improvement of one or more of eye fatigue, pressure, eyelid fatigue, tear flow, heat, dryness, pain, itchiness, eyelid spasms, afterimages, glare, blinding, hyperemia, dimness, foreign body, nausea and focusing time. Containing, food composition. delete The method of claim 1, wherein the anthocyanin is at least one selected from the group consisting of Malvidin Chloride, the idea chloride (Ideain chloride), Pelargonidin chloride and Keracyanin chloride (Keracyanin chloride) Food composition comprising a. The food composition of claim 1, wherein the ginseng fruit extract contains more ginsenoside PT (Protopanaxatriol) system than ginsenoside PD (Protopanaxadiol) system. delete delete According to claim 1, wherein the ginseng fruit extract
(a) pretreatment of ginseng fruit; And
(b) extracting the ginseng fruit pretreated in the above step with water or an organic solvent to obtain a ginseng fruit extract.

Images