KR101947624B1

KR101947624B1 - Multi type micro-needle

Info

Publication number: KR101947624B1
Application number: KR1020160182699A
Authority: KR
Inventors: 조성윤; 김종택; 추현욱
Original assignee: 랩앤피플주식회사
Priority date: 2016-12-29
Filing date: 2016-12-29
Publication date: 2019-02-14
Also published as: KR20180077879A

Abstract

According to the present invention, A plurality of needle balls provided on the substrate portion; And a needle portion provided on the base portion and protruding from the base portion to be inserted into the skin, wherein the needle portion is spaced apart from the needle portion at a predetermined interval along the circumferential direction of the needle portion at a portion of the base portion, And is provided with a plurality of units.

Description

Multi-type Micro Needle {MULTI TYPE MICRO-NEEDLE}

Field of the Invention [0002] The present invention relates to a multi-type micro needle patch, and more particularly, to a micro needle patch that attaches to a skin and delivers a drug-like substance to the skin.

Drug delivery system (DDS) refers to a series of techniques for delivering a substance having pharmacological activity to cells, tissues, organs and organs using various physicochemical techniques.

Drug delivery systems are most commonly used for oral administration of drugs, while transcutaneous delivery systems deliver drugs to a portion of the body. Among them, a drug delivery method using a syringe has been widely used for a long time by a method of delivering a liquid drug through a hole in a patient's skin with a metal needle.

However, the drug delivery system using a syringe has a disadvantage in that it causes pain to the patient when the drug is injected and also causes the patient to be infected due to the inconvenience of repeated inoculation and reuse of the injection needle due to the lack of management of the syringe have.

In addition, since the above method requires an inoculator having knowledge of the use of a syringe, there is a disadvantage in that the patient can not administer the drug using a syringe.

Therefore, in recent years, a micro-sized percutaneous transmission type micro needle which is much smaller than a pen-type syringe has been made and used for improving a drug delivery system using a syringe.

The micro needle is a system that physically punches holes in the stratum corneum and delivers the drug. In 1998, Prousnitz Group of Georgia Institute of Technology developed the micro needle array with silicon device using semiconductor process technology and proposed the possibility of drug delivery Many researches have been actively conducted and various sizes and shapes have been made based on various materials such as metals, polymers, glass and ceramics as well as silicon.

In addition, the micro needle is used for delivery of active substances such as drugs and vaccines in vivo, detection and biopsy of analyte in the body, and also for injecting skin cosmetic substances or drugs into the skin tissue, It is also used for the purpose of extracting the same body fluids. Accordingly, the micro needle can be localized and sustained drug injection, and minimizes pain upon insertion into the skin, which is one of the rapidly increasing drug delivery methods in various fields in recent years.

However, the conventional micro needle has a structural form that does not rapidly spread the drug into the body by the stratum corneum of the skin. 8, the conventional microneedle 10 has a base portion 1 attached to the skin in a state of being placed on an adhesive sheet (not shown), and a base portion 1 protruded on the base portion 1, Since the needle 2 has a simple structure in which the plurality of needles 2 are arranged in a matrix with a predetermined interval on the substrate 1, drug diffusion using transdermal drug delivery is inefficient.

Accordingly, recently, a method of enhancing transdermal drug delivery using a chemical enhancer, iontophoresis, electroporation, ultrasonic wave, and a thermal element has been continuously developed to improve the drug delivery rate However, this not only complicates the manufacturing process of the microneedle but also increases the manufacturing cost of the microneedle. In addition, the microneedle is often unsuitable depending on the form of the drug and causes side effects to the skin.

The base portion 1 of the microneedle 10 is generally manufactured using a mold, and the base portion 1 manufactured by a mold method is subjected to pressurization in a later process. Then, a plurality of needles 2 formed on the base plate 1 can be bent and protruded on the base plate 1 under the pressure of the press.

However, since the conventional micro needle 10 has a structure in which the needles 2 are arranged on the substrate portion 1 at a predetermined interval and in a plurality of positions as described above, the movable mold having a complicated structure, A movable mold having a pressing piece corresponding to and in contact with a plurality of needles 2 must be mounted.

When a plurality of needles 2 are pressed by a press equipped with the movable mold as described above, portions of the substrate portion 1 disposed between the plurality of needles 2 are deformed or damaged due to the influence of the pressing pieces There is a problem.

In particular, when the number of the needles 2 is increased to increase the delivery speed of the drug to be delivered subcutaneously to narrow the distance between the needles 2 very finely, 1 can be easily deformed or broken as it is disposed closer to the pressing piece.

Accordingly, the applicant of the present invention has proposed the present invention in order to solve the above problems, and related prior art documents include Korean Patent Application No. 10-2014-0105686 entitled " Micro needle patch 'and so on.

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a multi-type microneedle having needles arranged so that a drug to be delivered into the body can penetrate or diffuse quickly into the subcutaneous space, .

According to the present invention, A plurality of needle balls provided on the substrate portion; And a needle portion provided on the base portion and protruding from the base portion to be inserted into the skin, wherein the needle portion is spaced apart from the needle portion at a predetermined interval along the circumferential direction of the needle portion at a portion of the base portion, It can be arranged in a number of places.

The needle hole may be provided in the substrate portion in a circular or regular polygonal shape.

Further, the needle portion may be provided at the center of the inner side of the base portion that divides the needle ball when the needle ball is formed in a regular polygonal shape.

The needle portion may include a first needle having one end connected to the base portion while being received in the needle hole; A second needle received in the needle ball while being connected to the other end of the first needle; And a support hole provided on the first needle or the second needle.

In addition, the second needle may be formed in the shape of an arrowhead that gradually narrows in width from one end to the other end in the longitudinal direction, and one end thereof may be provided with a latching jaw having a width greater than the width of the other end of the first needle.

The supporting hole may be formed along the longitudinal direction of the first needle or the second needle and may have a shape in which the inner diameter gradually decreases from the upper surface of the first needle or the second needle toward the bottom direction have.

Further, the substrate portion may have a honeycomb structure when the needle ball is provided in the form of a regular hexagon.

Further, the substrate portion or the needle portion may be formed of a bioabsorbable metal.

In addition, a cutout portion may be provided at a connection portion between the first needle and the substrate portion, and the cutout portion may be provided at both ends in the width direction of the first needle at one end in the longitudinal direction of the first needle.

The cutout portion may include a slit hole provided at one end in the longitudinal direction of the first needle and between the both ends in the width direction of the first needle and one end in the longitudinal direction of the support hole.

The cutout portion may include a notch formed at both longitudinal ends of the first needle at both ends in the width direction of the first needle and communicably connected to the needle hole.

In addition, the bioabsorbable metal may include at least one of magnesium, calcium, zinc, and iron.

The multi-type micro needle according to an embodiment of the present invention has a structure in which a plurality of needles are arranged in a predetermined pattern around one needle hole, so that a plurality of needles are inserted into a predetermined area of the skin, Can quickly diffuse or infiltrate subcutaneously.

In the multi-type micro needle according to an embodiment of the present invention, since the substrate portion can have a honeycomb structure by a needle hole formed in the form of a regular hexagon, in the pressing process of pressing the needle portion, the substrate portion is deformed or damaged Can be minimized.

Further, since the multi-type micro needle according to the embodiment of the present invention can project a plurality of needle portions on the substrate portion without providing the number of the pressing pieces provided in the movable mold of the press equal to the number of the needle portions, The manufacturing cost can be reduced, and as a result, the manufacturing cost of the micro needle can be reduced and the manufacturing process can be simplified.

In addition, the multi-type micro needle according to an embodiment of the present invention may deliver a component (magnesium, calcium, zinc, iron, etc.) contained in a bioabsorbable metal in addition to a drug for treatment to the body to supply minerals .

In addition, the micro needle using the bioabsorbable metal according to an embodiment of the present invention is a simple process of separating the substrate portion contacting the skin on the skin, so that the needle portion can be left under the skin, So that the user can receive the bioabsorbable metal ions beneficial to the human body in the body without being subjected to any other procedure.

1 is a plan view of a micro needle patch according to an embodiment of the present invention;
Fig. 2 is an enlarged view of a portion A shown in Fig. 1; Fig.
3 is a perspective view showing a state in which a needle portion is erected according to an embodiment of the present invention;
4 is a cross-sectional view of a needle portion according to an embodiment of the present invention.
5 is a plan view showing a state in which a cutout portion is provided in a needle portion according to an embodiment of the present invention.
6 is a plan view showing a perforated portion formed in a circular shape according to an embodiment of the present invention.
7 is a plan view showing a state in which the perforations are formed in a regular octagonal shape according to an embodiment of the present invention.
8 is a perspective view of a conventional micro needle.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings.

It should be understood, however, that the invention is not limited to the disclosed embodiments, but is capable of many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, To fully disclose the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims.

Hereinafter, a micro needle patch according to an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 7. FIG. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted so as to avoid obscuring the subject matter of the present invention.

FIG. 1 is a plan view of a microneedle patch according to an embodiment of the present invention, FIG. 2 is an enlarged view of a portion A shown in FIG. 1, and FIG. 3 is a cross-sectional view showing a needle portion according to an embodiment of the present invention 4 is a cross-sectional view of a needle portion according to an embodiment of the present invention, FIG. 5 is a plan view showing a cutout portion provided in a needle portion according to an embodiment of the present invention, and FIG. FIG. 7 is a plan view showing a perforated portion formed in a regular octagonal shape according to an embodiment of the present invention, FIG. 8 is a perspective view of a conventional microneedle, to be.

1 to 7, a multi-type micro needle 100 according to an embodiment of the present invention includes a substrate unit 110, a plurality of needle holes 120 formed in the substrate unit 110, And a plurality of needle portions 130 provided at a predetermined interval along the circumferential direction of the needle holes 120 at a portion of the substrate portion 110 for partitioning the needle holes 120. [

The substrate portion 110 may have the form of a thin sheet having a predetermined area and thickness and may be provided in the form of a patch on the skin of the user while being placed on an adhesive sheet (not shown) .

In addition, the substrate 110 may be manufactured in various sizes and shapes corresponding to the skin region to be attached, and the periphery of the substrate 110 may be formed to have various curvatures so as to be in tight contact with the curved skin region. have. For example, when the substrate unit 110 is attached to the user's nose, it can be manufactured in the same shape as a known nose pack.

The substrate part 110 may be provided with a drug to be delivered under the skin. As a method of supporting the drug on the substrate 110, a method of coating the substrate 110 by immersing it in a container in which the drug is stored, a method of coating the drug on the substrate 110, Method can be used.

For example, the drug to be carried on the substrate 110 may be a drug for prevention and treatment of diseases, and is not limited thereto. For example, EGF (Epidermal Growth Factor: epithelial growth factor) Or hyaluronic acid.

The needle holes 120 may be formed by processing the substrate 110 with a laser cutting device. As described above, the needle holes 120 may be formed on the surface of the substrate 110 at regular intervals And may be provided in a plurality of numbers.

The needle holes 120 may be formed in the substrate 110 in a circular or regular polygonal shape. For example, as shown in FIG. 2 and FIG. 7, the substrate 110 may be provided in the shape of a regular hexagon or a regular octagon, but the present invention is not limited thereto. For example, 110).

2, the needle unit 130 includes a first needle 131, one end of which is connected to the base 110 in the longitudinal direction while being received in the needle hole 120, A second needle 132 received in the needle hole 120 and one end in the longitudinal direction thereof connected to the other longitudinal direction end of the first needle 131, (133).

The needle unit 130 configured as described above is arranged in a horizontal direction parallel to the surface of the substrate unit 110 and is vertically arranged on the surface of the substrate unit 110 by a pressing process using a molding process or a press apparatus. As shown in Fig. That is, the needle portion 130 may be a portion that is inserted under the user's skin to deliver the drug when the substrate portion 110 contacts the user's skin.
The needle portion 130 may be arranged so that the longitudinal direction of the needle portion 130 is perpendicular to the tangent line passing through the inner side of the substrate portion 110 defining the needle hole 120. [
2 and 6, each of the needle portions 130 formed on one needle hole 120 is spaced apart from one another in the longitudinal direction by one end of the needle portion 130, So that the angle between the adjacent sides can be elevated while maintaining the vertical angle. Thus, the skin can be bent at an angle that allows easy penetration of the surface of the skin.
That is, when the needle hole 120 is circular or has a regular polygonal shape as in the embodiment, the other longitudinal direction end of each needle portion 120 is radially extended toward the center of the area formed by the needle hole 120 .
The needle hole 120 may be formed in the needle hole 120. The needle hole 120 may be formed at a predetermined distance from the skin of the user, The drug can be effectively infiltrated or diffused rapidly and rapidly into the skin of the user exposed through the skin.

2, when the needle hole 120 is formed in a regular polygonal shape, the needle portion 130 is formed on the inner side 111 of the substrate portion for partitioning the needle hole 120 As shown in FIG.

If the needle portion 130 is provided at an inner vertex portion of the substrate portion 110 that divides the needle hole 120, a process of bending the needle portion 130 in the vertical direction The needle portion 130 may be broken. Therefore, in order to prevent the needle unit 130 from being split, the needle unit 130 is provided at a central portion of the inner side 111 of the substrate unit 110 that divides the needle hole 120 desirable.

The first needle 131 and the second needle 132 of the needle unit 130 may have a shape of an arrowhead as a whole so that the first needle 131 and the second needle 132 of the needle unit 130 can be easily inserted into the skin, The width may be gradually reduced toward the other end.

In addition, the second needle 132 is formed in the shape of an arrow that gradually decreases in width from one end to the other end in the longitudinal direction, and at one end thereof, (132a) may be provided.

The supporting hole 133 may be provided in the first needle 131 or the second needle 132 along the longitudinal direction of the first needle 131 or the second needle 132. [ For reference, in one embodiment of the present invention, the supporting hole 133 is formed in the first needle 131, and a part of the supporting hole 133 in the longitudinal direction is formed up to one end in the longitudinal direction of the second needle 132 Respectively.

The supporting hole 133 allows the amount of the drug to be carried on the first needle 131 or the second needle 132 to be adjusted.

That is, as shown in FIG. 4, the supporting hole 133 is formed so that the inner diameter gradually decreases from the upper surface of the first needle 131 or the second needle 132 toward the bottom direction The first needle 131 or the second needle 132 may be provided with a space in which the drug coating layer formed on the first needle 131 or the second needle 132 can be received.

The number of the first needle 131 or the second needle 132 may be determined according to the inner diameter of the support hole 133 or the number of the support holes 133 formed in the first needle 131 or the second needle 132. [ The amount of the drug carried on the needle 132 can be adjusted.

The multi-type micro needle 100 according to one embodiment of the present invention has a structure in which a plurality of needle parts 130 are provided at predetermined intervals on a needle hole 120 formed on a base part 110 Therefore, a drug intended to be supplied into the body can be intensively delivered to the subcutaneous tissue and rapidly spread.

The substrate unit 110 may have a honeycomb structure when the needle holes 120 are formed in the shape of a regular hexagon. The substrate unit 110 having a honeycomb structure is formed by pressing the needle holes 120 in the process of pressing the plurality of needle parts 130 disposed around the needle holes 120 with the pressing pieces of the press It is possible to prevent the portion 110a (see FIG. 1) of the substrate portion 110 from being deformed or broken by the pressing piece.

More specifically, in the process of inserting the pressing piece provided in the movable mold of the press into the needle hole 120, the needle part 120 is pressed and bent. At this time, There is a possibility that the portion 110a (see FIG. 1) of the substrate portion 110 disposed on the pressing portion 110 may be deformed or torn due to the influence of the pressing piece 110. FIG.

However, the multi-type micro needle 100 according to an embodiment of the present invention may have a honeycomb structure in which the needle hole 120 is formed in the form of a regular hexagon so that the substrate portion 110 110 can be increased to prevent the substrate 110 from being deformed or broken during a work process using a press.

In addition, the plurality of needle portions 130 may be bent and protruded from the base portion 110 by a single pressing piece inserted into one needle hole 120. Therefore, it is not necessary to arrange the number of the pressing pieces provided in the movable mold of the press in the number corresponding to the number of the needle portions 130, so that the structure of the movable mold can be simplified as a whole. The manufacturing cost of the mold is reduced, so that the manufacturing cost of the multi-type micro needle 100 can be reduced, and the manufacturing process can be simplified.

Meanwhile, the multi-type micro needle 100 according to an embodiment of the present invention may be formed of a bioabsorbable metal. That is, the substrate portion 110 or the needle portion 120 may be formed of a bioabsorbable metal composed of components beneficial to the human body.

That is, the substrate 110 may be made of a metal including at least one of magnesium, calcium, zinc, and iron, which is used as a bioabsorbable metal. Accordingly, The portion 130 is also made of a bioabsorbable metal.

In addition, when the substrate 110 is formed of a bioabsorbable metal, a cutout 140 may be further formed at a connection portion between the first needle 131 and the substrate 110.

The cutout part 140 may be formed in such a manner that the needle part 130 is separated from the substrate part 110 and remains on the skin when the substrate part 110 formed of a bioabsorbable metal contacts the skin and is separated .

5 (a) and 5 (b), the cutouts 140 are formed at both ends in the width direction of the first needles 131 at one end in the longitudinal direction of the first needles 131 Respectively.

5 (a), the cutout part 140 is formed at one end in the longitudinal direction of the first needle 131 and at both ends in the width direction of the first needle 131, The first needle 131 may be provided in the form of a slit hole which is disposed between one longitudinal end of the first needle 131 and the longitudinal direction of the first needle 131 as shown in Figure 5 (b) And may be provided in the form of a notch formed at both ends of the needle 131 in the width direction and communicably connected to the needle hole 120. [

The cutout portion 140 configured as described above is configured to allow the first needle 131 and the second needle 132 inserted subcutaneously to be subcutaneously left when the substrate portion 110 contacting the skin is separated on the skin And serves to reduce an area of a connecting portion of the first needle 131 in the longitudinal direction so that one end portion of the first needle 131 is easily broken on the substrate portion 110.

That is, the first needle 131 and the second needle 132 inserted under the skin can be stuck to the subcutaneous tissue by the contractive force of the subcutaneous tissue. When the first needle 131 and the second needle 132 are pulled by the force of the substrate 110 separated from the skin by the user larger than the contraction force of the subcutaneous tissue, the first needle 131 and the second needle 132 The needles 132 are forced to separate on the skin together with the substrate portion 110.

However, in an embodiment of the present invention, the cutout part 140 is formed at the connection part between the substrate part 110 and the first needle 131, so that the first needle 122 and the second needle 123 So that the first needle 131 and the second needle 132 can be left under the skin by damping the force provided to the substrate unit 110 so as to be smaller than the contraction force provided by the subcutaneous tissue will be.

The first needle 131 and the second needle 132 can be further adhered to the subcutaneous tissue since the engaging protrusion 132a formed on the second needle 132 can be caught in the subcutaneous tissue . Therefore, when the substrate 110, which is in contact with the skin, is separated on the skin, the connection portion between the first needle 131 and the substrate 110 can be more easily broken by the engagement protrusion 132a .

The first needle 131 and the second needle 132 remaining on the skin can subcutaneously deliver the drug carried on the substrate 110 and also transfer minerals contained in the bioabsorbable metal. That is, as the magnesium, calcium, zinc, and iron components used as bioabsorbable metals are subcutaneously transmitted, mineral components can be supplied to the body.

For reference, bioabsorbable metal has been made commercially in domestic and overseas for the application of magnesium based alloy for orthopedic implants. Bioabsorbable metals applied to orthopedic implants can be decomposed The focus was on reducing speed or improving corrosion resistance.

However, unlike the bioabsorbable metal used for orthopedic surgery, the bioabsorbable metal forming the multi-type micro needle 100 according to an embodiment of the present invention accelerates the decomposition rate in the body, Possible mechanisms can be applied.

For example, magnesium, calcium, and zinc used as bioabsorbable metals have a mechanism of reacting with water and releasing hydrogen gas and decomposing, as shown in the following Chemical Formulas 1 to 3, respectively.

The substrate portion 110 and the needle portion 130 formed of the bioabsorbable metal as described above emit ions and decomposition products under the skin and the hydrogen gas generated by the byproducts provides a swelling effect in the subcutaneous space, Lt; / RTI >

In addition, ZnO and MgCl 2, which are byproducts formed by inserting magnesium and zinc, which are constituents of the bioabsorbable metal, into the living body, remain on the surface of the skin subcutaneously, and the drugs carried on the substrate unit 110 and the needle unit 120 are subcutaneously Lt; RTI ID = 0.0 > enhancer < / RTI > Therefore, the substrate portion 110 and the needle portion 130, which are formed of the bioabsorbable metal, can effectively transmit the drug carried by the needle portion 130 to the user.

The shapes of the needle holes 120 and the needle portions 130 formed on the substrate 110 may be patterned on the substrate 110 by a known lithography or etching technique. .

At this time, since the substrate portion 110 formed of a bioabsorbable metal has lower corrosion resistance than a metal material such as stainless steel or iron, the edge of the needle portion 130 is formed by the lithography or etching technique It becomes thinner than the thickness of the original material itself and can be sharpened. That is, at the periphery of the first needle 131 or the second needle 132, a sharp inclined surface having a thickness smaller than the thickness of the first needle 131 or the second needle 132 is formed by the etching according to the lithography or etching technique, Can have a sharp shape.

Also, since the multi-type micro needle 100 according to the embodiment of the present invention has the needle hole 120 having a relatively large diameter or a large area rather than the needle hole formed in the conventional micro needle, Light therapy can also be performed through the ball 120 in parallel.

In other words, even if the substrate 110 is attached to the skin, the user's skin can be exposed to the outside through the plurality of needle holes 120, so that the exposed skin can be used for skin diseases such as skin pain, acne, It is possible to irradiate beneficial light and easily perform the light treatment.

Therefore, the user can be treated by the drug injected into the skin through the needle part 130 and diffused and the light irradiated through the needle hole 120, so that a synergy effect between the drug treatment and the light therapy can be expected have.

For example, in an embodiment of the present invention, light exposed to the skin through the needle hole 120 may be irradiated to the body to receive light therapy, but the present invention is not limited thereto. That is, a skin care substance or a skin treatment substance in a liquid state can be applied to the skin exposed through the needle hole 120 to perform a skin treatment treatment.

In addition, the substrate unit 110 can be brought into close contact with the skin of the user by the needle hole 120.

That is, since the needle hole 120 according to the embodiment of the present invention accommodates the plurality of needle portions 130 in one space, the needle hole formed in the conventional microneedles (only one needle can be accommodated) The user's skin is inserted into the needle hole 120 when the substrate 110 is in contact with the user's skin and a negative pressure is formed at the same time, The portion 110 can be more closely adhered to the skin.

Accordingly, the multi-type micro needle 100 according to the embodiment of the present invention may have a configuration in which the substrate portion 110 can be more closely attached to the user's skin by the needle hole 110. [

Since the multi-type micro needle 100 according to the embodiment of the present invention has a structure in which a plurality of needles are arranged in a predetermined pattern around one needle hole, a plurality of needles are inserted into a predetermined area of the skin, May rapidly diffuse or infiltrate into the subcutaneous tissue.

In the multi-type micro needle 100 according to an embodiment of the present invention, the substrate portion 110 may have a honeycomb structure by a needle hole 120 formed in the shape of a regular hexagon, It is possible to minimize the deformation or breakage of the substrate portion 110 by the press during the press-pressing process for bending.

In the multi-type micro needle 100 according to the embodiment of the present invention, the number of the pressing parts provided on the movable mold of the press is not equal to the number of the needle parts 130, So that it is possible to reduce the manufacturing cost of the movable mold of the press, and as a result, the manufacturing cost of the micro needle can be reduced and the manufacturing process can be simplified.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments.

Therefore, the scope of the present invention should not be limited by the described embodiments, but should be determined by the scope of the appended claims and equivalents thereof.

100: Multi-type micro needle
110: substrate portion 120: needle ball
130: needle portion 131: first needle
132: second needle 133: supporting ball
140:

Claims

A substrate portion in the form of a plate;
A plurality of needle balls provided on the substrate portion; And
And a needle portion protruding from the substrate and inserted into the skin,
Wherein the needle portion is provided at a plurality of positions spaced apart from each other along the circumferential direction of the needle hole at a portion of the substrate portion that divides the needle hole, and is pressed in a state of being horizontally arranged with the plate surface of the substrate portion, Wherein a length direction of the needle portion and a tangential direction of the needle hole connected to the needle portion are perpendicular to each other.

The method according to claim 1,
Wherein the needle hole is provided in the substrate portion in a circular or regular polygonal shape.

3. The method of claim 2,
Wherein the needle portion is provided at the center of the inner side of the substrate portion that divides the needle hole when the needle hole is formed in a regular polygonal shape.

The method according to claim 1,
The needle portion
A first needle having one end connected to the base portion while being received in the needle ball;
A second needle received in the needle ball while being connected to the other end of the first needle; And
And a support hole provided on the first needle or the second needle.

5. The method of claim 4,
Wherein the second needle is formed in the shape of an arrowhead that gradually narrows in width from one end in the longitudinal direction to the other end, and a hook having a width greater than the width of the other end of the first needle is provided at one end thereof. Micro needle.

5. The method of claim 4,
The supporting ball
Wherein the first needle or the second needle is formed along the longitudinal direction of the first needle or the second needle and the inner diameter gradually decreases from the upper surface of the first needle or the second needle toward the bottom direction.

3. The method of claim 2,
Wherein the base portion has a honeycomb structure when the needle ball is provided in the form of a regular hexagon.

8. The method according to any one of claims 1 to 7,
Wherein the substrate portion or the needle portion is formed of a bioabsorbable metal.

9. The method of claim 8,
And a cutout portion is provided at a connection portion between the first needle and the substrate portion,
Wherein the cut-out portions are provided on both sides in the width direction of the first needle at one longitudinal end of the first needle.

10. The method of claim 9,
The cut-
And a slit hole provided at one end in the longitudinal direction of the first needle and between both ends in the width direction of the first needle and one end in the longitudinal direction of the support hole.

10. The method of claim 9,
The cut-
And a notch formed at both ends in the width direction of the first needle at one end in the longitudinal direction of the first needle and communicably connected to the needle hole.

9. The method of claim 8,
Wherein the bioabsorbable metal is a metal containing at least one of magnesium, calcium, zinc, and iron.