KR101837433B1 - Nanoemulsion, preparing method thereof, and cosmetic composition containing the same - Google Patents

Abstract

The present invention relates to a nanoemulsion containing an effective component, a production method thereof, and a cosmetic composition containing the same. More specifically, the present invention relates to an ivory white oil-in-water nanoemulsion which ensures excellent water dispersibility, high stability, and uniform particle distribution. In addition, by using inulin lauryl carbamate as a main surfactant, sodium surfactin as a stabilizer, sodium dextran sulfate, or a mixture thereof, the nanoemulsion contains high amounts of liquid and solid effective components and effective dermally and physiologically active components. The present invention further relates to a cosmetic composition containing the same.

Description

TECHNICAL FIELD The present invention relates to a nanoemulsion containing an oil-soluble ingredient, a process for producing the same, and a cosmetic composition containing the same.

The present invention relates to a nanoemulsion containing an oil-soluble component, a method for producing the same, and a cosmetic composition containing the same. More particularly, the present invention relates to a nanoemulsion containing inulin lauryl carbamate as a main surfactant and sodium surfactant as a stabilizer, Dextran sulfate or a mixture thereof is used to prepare a nanoemulsion having a high content of a liquid or solid-phase oil-soluble ingredient and an oil-soluble skin-biologically active ingredient, etc. and having a uniform particle size distribution and high stability and excellent water dispersibility, And to a technique using the same.

Emulsion refers to a system in which one of the liquids that do not dissolve with each other, such as water and oil, is dispersed as fine particles in another liquid. Generally, microemulsions (10 to 100 nm), nano- It is divided into emulsion (20 ~ 500nm) and macro emulsion (1 ~ 100㎛). The requirements for making the emulsion are oil, water, surfactant and energy, which depend on the physical properties of each component and the miscibility with each component, the type and concentration of the surfactant, and the emulsification process conditions.

From a thermodynamic point of view, microemulsions are thermodynamically stable systems with very small particles, while nanoemulsions and macroemulsions are metastable systems, and macroemulsions are the most unstable. In general, microemulsions requiring 10 to 30% high concentration surfactant are most stable, but they have many limitations in application fields due to problems such as skin irritation caused by high concentration surfactants. Although the nano emulsion (3 biotech (2015) 5: 123-127) is slightly different according to the literature, it generally has a particle size of 20 to 200 nm and is less influenced by gravity than a macro emulsion having a particle size of 1 μm or more Since creaming or sedimentation does not occur and is mainly dominated by Ostwald ripening due to the difference in solubility between small particles and large particles, If the distribution is narrowed, it is stable for a long period of time under low viscosity conditions, and exhibits physical characteristics that appear to be transparent or translucent (suspended). In addition, it is possible to prepare a surfactant having a significantly smaller surface area than the microemulsion by providing a small interface with a wide interfacial film, thereby improving penetration of the active ingredient into the skin, giving a skin refreshing sensation at a low point, less skin irritation, . Due to this practical aspect, various researches are being conducted as basic technologies in the field of cosmetics, medicine, and chemistry.

The nanoemulsion is not formed spontaneously because it exists in a non-equilibrium state. Therefore, energy is required. The nano-emulsion can be produced by high-energy emulsification using a microfluidizer as a high-pressure emulsifier, D-phase emulsification, liquid crystal emulsification, PIT emulsification, PIC emulsification (Low energy emulsification). However, since the interfacial chemical method must pass through the region forming the endless aggregate (liquid phase, D phase) of the surfactant, which is the single phase region in which the surface tension approaches the theoretical zero or zero in the emulsification process, the surfactant, And has various limitations in that it contains various kinds of oil-soluble components due to the kind and composition of the oil, the emulsification temperature and the cooling condition. Therefore, in general, a high-pressure emulsification method is used to prepare nano-emulsions stably with various surfactants using a minimum amount of surfactant. It is important to select the process conditions and the emulsifier to manufacture the nanoemulsion.

In this nanoemulsion preparation method, a polycaprolactone-polyethylene glycol (PCL-PEG) block copolymer as main surfactant and a nanoemulsion composed of inulin lauryl carbamate and poloxamer as co-surfactants (Korean Patent Laid- 0073368), a nanoemulsion having 10 to 100 nm (Korean Patent Laid-Open No. 10-2003-0064986) using lecithin as a main surfactant and a lipopeptide system as a cosurfactant, lecithin and sodium diaramidoglutamidyl lysine (Korean Patent Laid-open Publication No. 10-2017-0023295), a nanoemulsion comprising lecithin, a nonionic surfactant and an anionic surfactant and containing 4 to 12% of an oil-soluble component (Korea Patent Publication No. 10-2011-0058240) .

Although a nanoemulsion can be prepared through the combination of various emulsifiers, phospholipid or lecithin is mainly used as a main surfactant in the prior art using a high-pressure emulsification method. Phospholipids and lecithins are expensive and have the disadvantage of poor stability at high temperatures (e.g., oil separation, creaming, discoloration, pumping, etc.). In addition, since it is naturally derived, it is difficult to uniformly control compositions such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) contained in the phospholipid, so that the particle size distribution of the dispersed phase is relatively wide, (O / W) nano emulsion made of lecithin is applied to the dispersed phase of the water-in-oil (W / O) emulsion, the stability is deteriorated with time, O / W) formulation.

Accordingly, the present inventors have made efforts to solve the problem of discoloration and discoloration that may occur during production, to secure high-temperature stability of the nanoemulsion produced, to further improve uniformity of particle size distribution to improve long-term stability, (W / O) formulation. As a result, it has been found that a surfactant, a polymer surfactant, is used as a surfactant, and a stabilizer such as sodium persectin, sodium dextran sulfate, or a mixture thereof The inventors of the present invention have invented a nano emulsion.

Korea Patent Publication No. 10-2009-0073368 (2009.07.03) Korean Patent Publication No. 10-2003-0064986 (Aug. 2003) Korean Patent Publication No. 10-2017-0023295 (Feb. Korean Patent Publication No. 10-2011-0058240 (June 1, 2011)

It is an object of the present invention to provide a nanoemulsion which contains a high content of an oil-soluble ingredient and has a uniform particle size distribution and is excellent in stability and water dispersibility.

It is another object of the present invention to provide a method for producing the nanoemulsion.

It is another object of the present invention to provide a cosmetic composition containing the nanoemulsion and having high stability in various formulations.

According to the present invention, there is provided a nanoemulsion comprising inulin lauryl carbamate as a surfactant and sodium surfactant, sodium dextran sulfate or a mixture thereof as a stabilizer. In this case, as the surfactant, the inulin lauryl carbamate is added in an amount of 1 to 10% by weight, more preferably 2 to 6% by weight based on the total weight of the nano emulsion, and sodium persectin, sodium dextran sulfate, 0.01 to 3% by weight, more preferably 0.05 to 1.0% by weight, based on the total weight of the nano emulsion.

Wherein the nanoemulsion comprises at least one oil soluble component selected from the group consisting of silicone oil, ester oil, hydrocarbon oil, vegetable oil, vegetable butter, wax, ultraviolet screening agent, 10 to 60% by weight, preferably 20 to 50% by weight.

The useful dermal biologically active ingredient is selected from the group consisting of ceramide, pseudo-ceramide, ubiquinone, astaxanthin, salicylic acid, azelaic acid, menthol, sphingosine, erucic acid and tetraacetyl phytosphingosine At least one selected from the range of 0.001 to 30% by weight based on the total weight of the nano emulsion.

The nano emulsion is characterized by having a milky white, low viscosity liquid phase or paste state and being easily dispersed in an aqueous phase.

According to the present invention, there is provided a water-based ink composition comprising (A) 1 to 10% by weight of inulin lauryl carbamate, 0.01 to 3% by weight of sodium surfactant, sodium dextran sulfate or a mixture thereof, To 90 < 0 > C, and stirring; (B) 10 to 60% by weight of at least one oil-soluble ingredient selected from the group consisting of silicone oil, ester oil, hydrocarbon oil, vegetable oil, vegetable butter, wax, Adding an oily component; (C) preparing a coarse emulsion with a homogenizer; And (D) homogenizing 1 to 7 times at a pressure of 500 to 2,500 bar using a high-pressure emulsifier.

According to another aspect of the present invention, there is provided a cosmetic composition comprising 0.1 to 100% by weight of the nanoemulsion based on the total weight of the cosmetic composition.

The cosmetic composition may be at least one selected from the group consisting of a cosmetic composition selected from the group consisting of softening agents, lotion, cream, pack, gel, patch or spray (mist), lipstick, makeup base or foundation, The composition is a detergent composition selected from the group consisting of a tonic, a gel, a mousse, a composition, a shampoo, a rinse, a body cleanser, a toothpaste, and an oral cleanser; or a hair tonic, a gel, a hair cosmetic or a hair dye.

Wherein the cosmetic composition contains inulin lauryl carbamate as a surfactant and sodium surfactant as a stabilizer and is selected from the group consisting of butyl methoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyltriazine, and diethylaminobydroxybenzoylhexylbenzoate (O / W) or a water-in-oil (O / W / O) multiple emulsion formulation, comprising at least one oil-soluble ultraviolet screening agent selected from the group consisting of water,

The nanoemulsion according to the present invention prepared by using the polymer inulin lauryl carbamate as a surfactant and the sodium succinate, sodium dextran sulfate or a mixture thereof as a stabilizer together with the cosmetic composition containing the same, And has a particle size of 100 to 200 nm and a uniform particle size distribution. It has a milky white appearance, has no discoloration and irregularity, remarkably improves high-temperature long-term stability, has excellent water-dispersibility, O / W) and water-in-oil (W / O) formulations, it is possible to maximize the utilization of the nano emulsion.

Fig. 1 is a schematic diagram showing the stabilization mechanism of the nanoemulsion of the present invention.
Fig. 2 is a graph showing the particle size of the nano-emulsion emulsion of Example 1 of the present invention.
Fig. 3 is a graph showing the sizes of the nanoemulsion emulsion particles of the present invention and Comparative Example 1. Fig.
4 shows the measurement results of the zeta potential of Example 1 of the present invention.
Fig. 5 shows the measurement results of the zeta potential of the present invention and Comparative Example 1. Fig.
Fig. 6 is a graph showing the sizes of the nanoemulsion emulsion particles of the present invention and Example 4. Fig.
Fig. 7 shows the sizes of the nanoemulsion emulsified particles of the present invention and Example 5. Fig.
8 is a stability sample stored at room temperature and 45 ° C for 1 month in the nanoemulsion of Example 1 and Comparative Example 1, respectively.
9 is a stability sample stored for 1 month at 4 ° C and 45 ° C at room temperature of the 1 wt% aqueous dispersion of the present invention and Example 3. Fig.
Fig. 10 shows the ease of dispersion of the nanoemulsion of the present invention, Example 1, and Comparative Example 2 in water.

The present invention relates to the use of a polymeric inulin lauryl carbamate as a surfactant without the use of lecithin or other phospholipids as a surfactant, and also to provide a high concentration of sodium laurylcarbamate by using sodium surfactant, sodium dextran sulfate, It is a technical feature to produce a nano emulsion containing an oil-soluble component, exhibiting a uniform particle size distribution, high-temperature long-term stability, and excellent water dispersibility and being applicable to various formulations.

The nanoemulsion of the present invention comprises 1 to 10% by weight, preferably 2 to 6% by weight, of a surfactant, inulin lauryl carbamate, and the stabilizer sodium surfactant, sodium dextran sulfate, By weight, preferably 0.05 to 1.0% by weight. The long-term stability of the nanoemulsion is excellent when it is included in the above ratio.

The surfactant, Inulin Lauryl Carbamate, is a non-ionic polymer. It has a structure in which a hydrophobic lauryl group is crafted in a straight-chain polyfructose, and the aggregation or coalescence is reduced by a steric stabilization mechanism, It serves to stabilize the ingredients.

The sodium surfactin used as a stabilizer in the present invention is an anionic surfactant having a unique structure consisting of a hydrophilic cyclic peptide made of seven amino acids and a lipophilic hydrocarbon. Sodium Dextran Sulfate is used as a medicinal product to improve hyperlipemia. It is produced by fermenting sucrose bacteria of Leuconostoc, a kind of lactic acid bacteria, and dextran (glucose is mainly produced by α-1,6 bond A sodium salt of a sulfuric acid ester obtained by sulfating a partial hydrolyzate of a polymerized polysaccharide,? -1,6 glucan), and has an average molecular weight of about 1,600 and exhibits an anionic property.

In the present invention, the sodium laurylcarbamate having a stabilization mechanism due to the steric structure is used together with sodium persectin, sodium dextran sulfate, or a mixture thereof, having a mechanism of stabilizing the zeta potential on the particle surface The long-term stability of the nanoliposome, which could not be ensured only by the three-dimensional stabilization of the surfactant, could be secured (Fig. 1).

The nanoemulsion of the present invention may contain 10 to 60% by weight of an oil-soluble component, preferably 20 to 50% by weight, based on the total weight of the composition. If it is less than 10% by weight, sufficient water solubility balance of the nano emulsion can not be obtained. If it exceeds 60% by weight, it is difficult to secure stability over time.

In the present invention, the oil-soluble component means an oil-in-water physiologically active ingredient as well as a liquid-phase and solid-phase oil-soluble ingredient. The solid-phase oil-soluble component is a solid at room temperature and includes at least one member selected from the group consisting of fats, waxes, higher alcohols, higher fatty acids and hydrocarbons. For example, fats such as shea butter and mango seed butter, waxes such as carnauba wax, candelilla wax and rice flour, higher alcohols such as cetyl alcohol, stearyl alcohol and behenyl alcohol, lauric acid, myristic acid , Higher fatty acids such as palmitic acid and stearic acid, hydrocarbons such as paraffin, ceresin and microcrystalline wax, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyltriazine, diethylaminohydroxybenzoylhexylbenzoate and the like , And the like, but the present invention is not limited thereto.

The liquid-phase oil-soluble component includes at least one member selected from the group consisting of oils, esters, hydrocarbons and silicon. For example, vegetable oils such as meadowfoam seed oil, sunflower seed oil, green tea seed oil, and camellia oil, cetyl ethylhexanoate, octyldodecyl myristate, pentaerythritol tetraethylhexanoate, isopropyl palmitate And esters such as isopropyl myristate, liquid paraffin, hydrocarbons such as squalane, isohexadecane, hydrogenated polydecene and hydrogenated polyisobutene, cyclomethicone, dimethicone, phenyltrimethicone, and fluorosilicone Of isostearic acid, isostearic acid, isostearic alcohol, and the like, but is not limited thereto.

The useful skin biologically active ingredient used in the present invention is a skin active substance which is useful for the skin physiology such as ceramide, pseudoceramide, ubiquinone, astaxanthin, salicylic acid, azelaic acid, menthol, sphingosine, rustic acid, tetraacetyl phytosphingosine And at least one selected from the group of imparting the function, but the present invention is not limited thereto. Such an oil-soluble skin biologically active ingredient may contain 0.001 to 30% by weight based on the total weight.

According to an embodiment of the present invention, a method of manufacturing the nanoemulsion includes the following steps.

First, an oily component uniformly dissolved at 20 to 90 ° C is added to the aqueous phase components such as inulin lauryl carbamate, sodium surfactant and preservative at 20 to 90 ° C with stirring, and the mixture is homogenized with a TK homogenizer A coarse emulsion is prepared at 3,000 rpm for 5 minutes. Then, the coarse emulsion is cooled / homogenized at a temperature of 10 to 20 ° C at a pressure of 500 to 2,500 bar in a high-pressure emulsifier by repeating 1 to 7 times to prepare a nano emulsion.

The nanoemulsion of the present invention produced by the above-described method has a particle size of 100 to 200 nm, has a uniform particle size distribution, is free from discoloration and modification during manufacture, has excellent long-term stability and water dispersibility, Both water-in-oil emulsions have demonstrated the applicable benefits.

According to the present invention, there is provided a cosmetic composition containing the nanoemulsion thus prepared as an active ingredient in an amount of 0.1 to 100% by weight based on the total weight of the cosmetic composition.

The formulation of the cosmetic composition containing the nanoemulsion according to the present invention is not particularly limited and may be suitably selected from the group consisting of a cosmetic composition such as a softening agent, a lotion, a cream, a pack, a gel, a patch or a spray (mist), a lipstick, Such as color toning cosmetic compositions such as foundation, sunscreen cosmetic composition such as suntan lotion, gel or mousse, detergent compositions such as shampoo, rinse, body cleanser, toothpaste, mouthwash or hair tonic, gel, A cosmetic composition for hair, and can be widely applied to medicines such as lotion, ointment, gel, cream, mousse, etc., patches or spray agents, and quasi drugs.

[Example]

Hereinafter, the present invention will be described more specifically with reference to examples and comparative examples. It is to be understood that the scope of the present invention is not limited to these examples and test examples, and that variations, substitutions, and insertions conventionally known in the art And this is also included in the scope of the present invention.

Example  1 to 10 and Comparative Example  1 to 3: Nano-emulsion  Produce

Nano emulsion was prepared according to the compositions shown in Tables 1 and 2 (unit: wt%).

<Manufacturing Method>

1) The water components are heated to 70 ~ 75 ℃ to dissolve uniformly.

2) The oil components are completely dissolved by heating to 80 ~ 85 ℃.

3) Using the homomixer, homogeneously mix for 5 minutes at 3000 rpm while the above 2) is added to 1) above.

4) The above 3) is repeatedly homogenized 4 times at 1000 bar in a high-pressure emulsifier.

Example  11-13 and Comparative Example  4: Lotion production

The lotion containing the nanoliposome prepared in the above Example was prepared according to the composition shown in Table 3 below, and the stability test results are shown in Table 3 (unit: wt%).

<Manufacturing Method>

1) The water components are heated to 70 ~ 75 ℃ to dissolve uniformly.

2) The thickener is homogeneously dispersed in 1) and neutralized.

3) The nanoemulsions of Examples 3, 5, 6, and 7 are placed in the above 2) and homogeneously mixed using a homomixer or a disper.

Example  14 and Comparative Example  5 ~ 6: Manufacture of cream

The cream containing the nanoliposome prepared in the above Example was prepared according to the composition shown in Table 4, and the stability test results are shown in Table 4 (unit: wt%).

<Manufacturing Method>

1) The aqueous phase components are heated to 70 to 75 ° C to dissolve / disperse uniformly.

2) Fully dissolve the oil components by heating to 70 ~ 75 ℃.

3) Put 2) in 1) above and emulsify for 5 minutes at 3000rpm using a homomixer.

4) Increasing agent is put into 3) and it is increased by using homomixer.

5) The nanoemulsion of Example 2 or Comparative Example 3 was put in the above 4) and uniformly mixed using a homomixer.

Example  15 and Comparative Example  7: Bibi Cream's  Produce

The bibby creams containing the nanoliposomes prepared in the above Examples were prepared according to the composition shown in Table 5 below, and the stability test results are shown in Table 5 (unit: wt%).

<Manufacturing Method>

1) The oil components are heated to 70 ~ 75 ℃ to dissolve / disperse uniformly.

2) Powder ingredients are added to 1) above and dispersed at 3000 rpm for 30 minutes using a homomixer.

3) The aqueous phase components are completely dissolved by heating to 70 to 75 ° C, and the nanoemulsion of Example 5 is uniformly mixed.

4) Put 1) in 2) above and emulsify at 3000 rpm for 10 minutes using a homomixer.

Example  16 and Comparative Example  8: Manufacture of sunscreen

The sunscreen containing the nanoliposome prepared in the above Example was prepared according to the composition shown in Table 6 below, and the stability test results are shown in Table 6 (unit: wt%).

<Manufacturing Method>

1) The oil components are heated to 70 ~ 75 ℃ to dissolve / disperse uniformly.

2) Powder ingredients are added to 1) above and dispersed at 3000 rpm for 30 minutes using a homomixer.

3) The aqueous phase components are completely dissolved by heating to 70 to 75 ° C, and the nanoemulsion of Example 4 is homogeneously mixed.

4) Put 1) in 2) above and emulsify at 3000 rpm for 10 minutes using a homomixer.

Test Example  One: Liquid phase  Comparison of stability against oil-soluble components, solid-phase oil-soluble components and oil-soluble components

Immediately after the preparation of the emulsions of Examples 1 to 10 and Comparative Examples 1 to 3, the stability of the nano emulsion with respect to the average particle size and the aging of the emulsion was confirmed, and the results are shown in Table 7 below.

The average particle size of the emulsion was determined based on the Z-average value using a zetaizer (Zetasizer Nano ZS, Malvern) capable of measuring particle size, polydispersity index and zeta potential using dynamic light scattering characteristics.

In order to examine the stability of the nano-emulsion according to the aging change, the nano emulsion and purified water prepared in Examples 1 to 10 and Comparative Examples 1 to 3 were diluted to 1% by weight and then cooled at room temperature, The cells were stored and observed at high temperature (45 ° C) for 1 week, 2 weeks, and 4 weeks apart.

(?: Good, X: separated,? Changed)

(*) 1% by weight of the nanoemulsion of Examples 1 to 10 and Comparative Examples 1 to 3 was diluted to 99% by weight of purified water

As shown in the results of Table 7, in the case of inulin lauryl carbamate alone, the zeta potential is -10.9 mV [Fig. 5] and the particle size is 146.9 nm (Fig. 3) , The zeta potential in Example 1 containing sodium surfactant was -63.7 mV (Fig. 4), and the particle size was 124.7 nm (Fig. 2). Compared with the stability of the nano emulsion, the nano emulsion having a particle size of 200 nm or less can be obtained even with inulin lauryl carbamate alone. However, as shown in FIG. 8, the stability is very poor after lapse of time. It can be seen that the inulin lauryl carbamate can stabilize the nano emulsion temporarily by sterical stabilization but the stability is deteriorated by creaming and sedimentation with time, The stabilization of the nano emulsion can be seen even after the elapse of time due to the steric stabilization and the electrical repulsion due to the high zeta potential. In addition, nanoparticles of 200 nm or less could be obtained even with a small amount of sodium surfactant added, and smaller particles could be obtained according to the content of sodium surfactant (Comparative Example 1, Examples 1, 8, and 9) . Examples 1, 2, 3, 4, 5, 6, 7, 8, and 9, in which sodium persulfate was used as a surfactant and sodium surfactant was used, were added to vegetable oil, silicone oil It can be seen that a nano emulsion of 200 nm or less can be obtained regardless of the kinds of oil soluble ingredients such as a blocking agent (Fig. 6) and ceramide which is an oil-soluble skin biologically active substance (Fig. 2). 9 shows that the 1% by weight diluted sample of the nano emulsion containing 20% by weight of the high melting point ceramide shows stability when stored for 4 weeks, and it is stably maintained without precipitation or creaming. In the case of Comparative Example 1, long-term stability could not be ensured regardless of the storage temperature condition. For nanoemulsion using lecithin as the main surfactant, the zeta potential was -71.2 mV, -72.6 mV, and the particle size was 146.5 nm and 153.7 nm Stable nanoparticles could be obtained, but the long - term storage was observed and the long - term stability of the high temperature was lowered as the content of the oil component increased. It was also found that sodium dextran sulfate of Example 10 also had a stable nanoemulsion. In the case of a uniform particle size distribution, the polydispersity index of each of Examples and Comparative Examples showed a uniform particle size distribution of 0.20 or less.

Thus, by using inulin lauryl carbamate as a surfactant and using sodium surfactant, sodium dextran sulfate and a mixture thereof as a stabilizer, a nano emulsion having a high content of an oil-soluble component and having a uniform particle size distribution and excellent long-term stability can be produced can do.

Test Example  2: Nano-emulsion  Properties and Water dispersion  Ease

The properties and dispersibility of the nanoemulsion of Examples 1 to 10 and Comparative Examples 1 to 3 were confirmed and are shown in Table 8 below.

The above-mentioned properties are as follows: a liquid having a high fluidity when visually observed and a cream having no fluidity but easily pay-off is a paste, a fluid having no fluidity, and a payoff not easy.

The water phase easiness was evaluated as follows: 1% by weight of the nano emulsion prepared in Examples 1 to 10 and Comparative Examples 1 to 3 was added to 99% by weight of purified water, (Normal) to be dispersed by a handmixing alone and dispersed by a machine such as a homomixer or a dispenser, and x which is not easily dispersed by a machine.

From the results of Table 8, it was possible to prepare milky white liquid or paste-like nanoemulsion having low to intermediate viscosity in Examples 1 to 10. Comparative Examples 1 to 3 were able to produce nanoemulsions of liquids, pastes or creams having a low viscosity and a high viscosity. In the case of Comparative Examples 2 and 3, a translucent paste and a cream phase were shown. Comparing Examples 1 to 10 and Comparative Examples 2 and 3, it can be seen that the embodiment is a nano emulsion having milky white properties, unlike the comparative examples. As can be seen from Fig. 10, Example 1 showed excellent water dispersibility. In Comparative Examples 2 and 3, water dispersibility was relatively low, mechanical benefits such as an agitator and a long time were required, while Examples 1 to 10 were easily dispersible in water phase by hand mixing or with a slight mechanical assistance.

This means that it can be easily applied regardless of processes such as dosage form (oil-in-water or water-in-oil) and the order of injection in the production of a cosmetic composition. Therefore, a nanoemulsion can be produced which is free from cosmetic formulation and manufacturing process by using inulin lauryl carbamate as a surfactant and sodium surfactant, sodium dextran sulfate and a mixture thereof as stabilizers.

Test Example  3: Containing sunscreen Nano emulsion  And sunscreen effects

The water-in-oil type emulsion containing the stable solid type ultraviolet screening oil-soluble component was able to be produced through the Example 4, and the water-in-oil type emulsion of Example 16, the water-in-water type emulsion of Comparative Example 8 and the UV- Table 9 shows the results.

The above-mentioned aging changes were observed and observed in Example 16 and Comparative Example 8 at 1, 2, and 4 weeks intervals at room temperature, 4 캜 and 45 캜, respectively.

The ultraviolet blocking effect was measured by applying 2 mg / cm 2 to a Transpore tape (3M) using an optical measuring instrument (model name: SPF-290S, Optometrics) as an In-Vitro test method.

The results of Table 9 show that when the oil-soluble ultraviolet screening agent was added to water phase water-in-oil (W / O) formulations using inulin lauryl carbamate as a surfactant and sodium surfactant as a stabilizer, It was possible to produce multiple emulsions of oil-in-water type (O / W / O) having excellent long-term stability. Further, as a result of measuring the ultraviolet blocking effect, 8.7% in SPF and 38% in PFA, compared with Comparative Example 8 in which the same ultraviolet screening agent of the same composition was directly applied to a water-in-oil (W / O) . This was the same as the result of previous studies that the sunscreen oil (O / W / O) sunscreen is superior to UV / UV sunscreen when using the same ultraviolet screening agent (Fragrance Journal 2007-4 p 70- 75). Therefore, by applying a nanoemulsion containing an oil-soluble ultraviolet screening agent to a water-in-oil type formulation using inulin lauryl carbamate as a surfactant, sodium surpectin as a stabilizer, and a sunscreen having an excellent long- Can be prepared.

Claims (9)

In the nano emulsion, 1 to 10% by weight of inulin lauryl carbamate is added as a surfactant to the total weight of the nano emulsion, and 0.01 to 3% by weight of sodium surfactant is added as a stabilizer to the total weight of the nano emulsion. Underwater type (O / W) nano emulsion having a low viscosity liquid or paste form. delete The nanoemulsion according to claim 1, wherein at least one oil component selected from the group consisting of a silicone oil, an ester oil, a hydrocarbon oil, a vegetable oil, a vegetable oil, a wax, an ultraviolet screening agent, (O / W) nanoemulsion comprising 10 to 60% by weight based on the total weight of the composition. 4. The composition of claim 3, wherein the oil-soluble skin biologically active ingredient is selected from the group consisting of ceramide, pseudo-ceramide, ubiquinone, astaxanthin, salicylic acid, azelaic acid, menthol, sphingosine, (O / W) nanoemulsion, characterized in that it is at least one selected from the group consisting of nanoemulsions and tossed gums and is contained in an amount of 0.001 to 30% by weight based on the total weight of the nano emulsion. delete (A) heating and stirring an aqueous phase component comprising from 1 to 10% by weight of inulin lauryl carbamate and 0.01 to 3% by weight of sodium surfactant to 20 to 90 캜;
(B) 10 to 60% by weight of at least one oil-soluble ingredient selected from the group consisting of silicone oil, ester oil, hydrocarbon oil, vegetable oil, vegetable butter, wax, Adding a component;
(C) preparing a coarse emulsion with a homogenizer; And
(D) homogenizing 1 to 7 times at a pressure of 500 to 2,500 bar using a high-pressure emulsifier. A cosmetic composition characterized by containing 0.1 to 100% by weight of the water-in-oil (O / W) nanoemulsion according to any one of claims 1, 3 and 4, based on the total weight of the cosmetic composition. The cosmetic composition according to claim 7, wherein the cosmetic composition is a cosmetic composition selected from cosmetic compositions, lipsticks, makeup bases or foundations selected from softening longevity, lotion, cream, pack, gel, patch or spray (mist) Cosmetic composition selected from sunscreen compositions, shampoos, rinses, body cleansers, toothpastes, oral cleansers, or hair tonics, gels, hair tonics, and hair dye cosmetics selected from ultraviolet light cosmetic compositions, hair tonics, gels or mousses &Lt; / RTI &gt; 8. The cosmetic composition according to claim 7, wherein the cosmetic composition comprises inulin lauryl carbamate as a surfactant, sodium surfactant as a stabilizer, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyltriazine, and diethyl Wherein the sunscreen comprises at least one oil-soluble ultraviolet screening agent selected from the group consisting of aminohydroxybenzoylhexyl benzoate and multiple emulsion formulations in water-in-water type (O / W / O).

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