KR102594145B1 - Nanoemulsion of translucent formulation containing natural ceramide and manufacturing method thereof and manufacturing method of customized cosmetics including the same - Google Patents

Abstract

Disclosed in the present invention are a nano-emulsion of a translucent formulation containing natural ceramide, a manufacturing method thereof, and a manufacturing method of a personalized cosmetic product including the same, wherein the nano-emulsion of a translucent formulation containing natural ceramide can strengthen skin barrier and enhance moisturizing power by containing a high content of ceramide, and the nano-emulsion is stably formulated without precipitation by the translucent formulation distributed in small particles with an average particle diameter of 40 to 80 nm, such that functional ingredients that are customized according to the skin type or constitution of a customer in a personalized cosmetic product are stably maintained to facilitate the manufacture.

Description

Nanoemulsion of translucent formulation containing natural ceramide and manufacturing method thereof and manufacturing method of customized cosmetics including the same}

The present invention relates to a nanoemulsion of a translucent formulation containing natural ceramide, a method of manufacturing the same, and a method of manufacturing customized cosmetics containing the same. More specifically, a nanoemulsion of a translucent formulation containing natural ceramide contains a high content of ceramide. It can strengthen the skin barrier and improve moisturizing power, and by stably formulating it as a nanoemulsion without precipitation due to the translucent formulation distributed in small particles with an average particle size of 40 ~ 80nm, nanoemulsion can be used in personalized cosmetics for customers. It relates to a nanoemulsion of a translucent formulation containing natural ceramide that can be easily manufactured by stably maintaining functional ingredients customized according to skin type or constitution, a method of manufacturing the same, and a method of manufacturing customized cosmetics containing the same. .

In general, the skin barrier is made up of a phospholipid structure that prevents bacteria and viruses from entering from the outside to protect the skin, while also selectively absorbing necessary substances. Ceramide is the main component of lipids between keratinocytes that plays a very important role in the skin barrier, preventing moisture loss and protecting against external harmful environments and pollution.

In skin lacking ceramide, moisture in the skin evaporates quickly, which can lead to dryness that causes the skin to crack or peel off. Natural ceramide is a type of sphingolipid that has a structure in which a fatty acid is linked to sphingosine. It accounts for more than 40% of the interstitial lipids that make up the stratum corneum. It acts as a lipid barrier to suppress moisture evaporation and acts as a lipid barrier to the stratum corneum. It has the function of maintaining an orderly structure.

Therefore, it is widely known that applying a preparation containing natural ceramide to the skin helps improve skin barrier function and moisturize the skin. However, natural ceramides are difficult to mass-produce due to difficulties in extraction, and the raw materials are expensive, so there are many difficulties in producing them as products.

These natural ceramides are poorly soluble substances with a melting point of over 100°C. Due to their structural characteristics, when contained in large quantities in cosmetics, they crystallize and precipitate, or when the particles are made small, the surface energy increases and the attractive force acts to easily combine, further leading to a gelling phenomenon. Ceramide cannot be used in high amounts in flowable formulations such as lotion or clear skin.

Republic of Korea Patent No. 10-1473198 (Reference 1) has been proposed as a prior art to solve this problem. Reference 1 relates to a cosmetic composition containing a transparent ceramide emulsion. It contains ceramide in a transparent formulation using lecithin, medium chain triglyceride, glycerin, and anionic surfactant. There is a limit to applying ceramide up to 5% by weight. , the particle size is 80 nm or more, which is inferior to those manufactured with 80 nm or less in terms of stability and skin absorption. Republic of Korea Patent No. 10-1837433 (Reference 2) relates to a nanoemulsion containing oil-soluble ingredients, a manufacturing method thereof, and a cosmetic composition containing the same. Inulin lauryl- as a surfactant to contain a high content of ceramide. It is characterized by containing sodium surfectin as a carbamate and a stabilizer. However, although the composition itself has excellent stability, it is a milky white formulation with a particle size of 100 to 200 nm, which has limitations in skin penetration and is difficult to use in transparent formulations. There is a downside.

Therefore, there is a need for a technology that can overcome the limitations of these prior technologies and stabilize the nanoemulsion formulation containing a high content of ceramide in a translucent manner.

Emulsion refers to the form of water droplets (droplets) formed between two stable immiscible fluids due to surfactants. Emulsions with various layers and shapes have recently been widely used in drug delivery, cosmetics industry, and material fields.

Recently, with the emphasis on individual individuality, data-based decision-making, and advances in convergence technologies such as ICT, BNT, and BIT, 'personalized services' in various fields are attracting attention as a future growth engine. Specifically, various customized products for each individual ranging from services based on artificial intelligence, cloud, and big data in the 4th industrial sector to services in the health, medical, health care, and beauty fields by analyzing each individual's current skin condition and genetic polymorphism. , is continuously evolving into a medical procedure and service business.

After the launch of D2C (Direct to Consumer) service for individual genetic polymorphism (SNP: Single Nucleotide Polymorphism) in 2020 and the implementation of the customized cosmetics dispensing manager system, products are divided on site by reflecting individual skin type, preference, genetic polymorphism, etc. It has become possible to sell personalized cosmetics by mixing and selling them.

Currently, the manufacturing and sales method of customized cosmetics reduces the number of target trait combinations of customized cosmetics as much as possible and provides pre-manufactured products or mixes sub-products for each trait according to the results of each individual's skin diagnosis. This is how it is provided to customers.

However, with current manufacturing technology, it is difficult to simultaneously improve the stability of the formulation and increase the number of possible combinations for personalized cosmetics. Therefore, research is in progress to prepare a stable nanoemulsion base formulation in advance and use it when manufacturing personalized cosmetics.

Korea Registration Notice No. 10-1533947 (Notice Date: 2015.07.10) Korea Registration Notice No. 10-0539965 (Public Notice Date: 2006.01.10)

The purpose of the present invention is that a nanoemulsion of a translucent formulation containing natural ceramide can strengthen the skin barrier and improve moisturizing power by containing a high content of ceramide, and is distributed in small particles with an average particle diameter of 40 to 80 nm. By stably formulating a nanoemulsion without precipitation, the nanoemulsion is a natural ceramide that can be easily manufactured by stably maintaining functional ingredients tailored to the customer's skin type or constitution in personalized cosmetics. The aim is to provide a nanoemulsion containing a translucent formulation, a method for manufacturing the same, and a method for manufacturing customized cosmetics containing the same.

A nanoemulsion containing natural ceramide according to an embodiment of the present invention to solve the above problems includes 0.5 to 10% by weight of natural ceramide; 0.3 to 5.0% by weight of functional peptide; 0.1 to 4.0% by weight of ionic surfactant; Fatty acid 0.1 to 4.0% by weight; 10 to 70% by weight of polyol; and the remaining amount of purified water, and are characterized by being micronized into nanoparticles by applying nanotechnology to pass them through a high-pressure emulsifier, and having an average particle diameter of 40 to 80 nm.

The functional peptide includes one or more selected from Copper Tripeptide-1 and Palmitoyl Tripeptide-1, and the ionic surfactant is Sodium Stearoyl Glutamate. Glutamate, Sodium Lauryl Glutamate, Potassium Cetyl Phosphate, Glyceryl Stearate Citrate, and Distearyl Dimonium Chloride. Contains more than one type.

The fatty acid includes one or more selected from lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, and behenic acid, and the polyol includes glycerin, 1,3-butyl 1,3-Butylene Glycol, Propylene Glycol, Pentylene glycol, Propanediol, Methyl Propanediol and Dipropylene Glycol Glycol).

The nanoemulsion of the translucent formulation may further include 3.0 to 20% by weight of oil.

The nanoemulsion of the translucent formulation contains 33 to 43% by weight of glycerin, 2.0% by weight of pentylene glycol, 0.5 to 2.0% by weight of sodium stearoyl glutamate, 10 to 15% by weight of octyldodecanol, and hydrogenated poly (C6- 14 olefin) 4 to 9% by weight, oleic acid 0.4 to 2.8% by weight, functional peptide 1 to 4% by weight, natural ceramide 1 to 10% by weight, and the remaining amount of purified water.

The method for producing a nanoemulsion containing natural ceramide according to an embodiment of the present invention to solve the above problem is (a) measuring and mixing polyol, ionic surfactant, and purified water, followed by primary heating and stirring to form a primary mixture. forming a; (b) measuring and mixing natural ceramide, functional peptide, and fatty acid, followed by secondary heating to form a secondary mixture; and (c) performing high-pressure emulsification of the primary and secondary mixtures through a high-pressure emulsifier and then cooling them to form a nanoemulsion of a translucent formulation. After step (c), the nanoemulsion of the translucent formulation is Nanoemulsions are micronized into nanoparticles by applying nanotechnology to pass them through a high-pressure emulsifier, and are characterized by having an average particle size of 40 to 80 nm.

In step (c), the high-pressure emulsification is performed at a pressure of 300 to 1,500 bar under conditions of 30 to 70°C.

To solve the above problems, a method for manufacturing customized cosmetics containing a nanoemulsion of a translucent formulation containing natural ceramide according to an embodiment of the present invention is (a) using the user's terminal or smart diagnostic device to measure the user's skin and Obtaining skin input information; (b) generating skin diagnosis information about the user's skin condition based on the skin input information and skin measurement information; (c) generating prescription data for manufacturing customized cosmetics based on the skin diagnosis information; and (d) manufacturing customized cosmetics based on the prescription data, wherein the customized cosmetics includes a nanoemulsion of a translucent formulation containing natural ceramide and a sub-cosmetic formulation containing functional ingredients, and the nanoemulsion The emulsion is characterized by having an average particle diameter of 40 to 80 nm.

The functional ingredient uses one or a mixture of two or more selected from moisturizing functional ingredients, wrinkle or elasticity improving functional ingredients, whitening functional ingredients, pigmentation functional ingredients, skin soothing functional ingredients, and sebum or pore management functional ingredients.

The translucent nanoemulsion containing natural ceramide according to the present invention and the method for manufacturing the same, as well as the method for manufacturing customized cosmetics containing the same, not only improve the stability of active ingredients such as functional peptides and natural ceramides contained in the internal droplets, but also improve the stability of the active ingredients. The encapsulation efficiency is increased, and a formulation with improved stability and uniform droplet size can be manufactured.

In addition, the nanoemulsion of a translucent formulation containing natural ceramide according to the present invention and the method of manufacturing the same, as well as the method of manufacturing customized cosmetics including the same, apply the nanoemulsion of a translucent formulation containing natural ceramide to the production of customized cosmetics, thereby improving consumer confidence. The stability of functional ingredients that correspond to skin type or constitution can be improved, and the number of individually customized prescriptions can be easily increased.

Figure 1 is a process flow chart showing a method for producing a translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention.
Figure 2 is a process flow chart showing a manufacturing method of customized cosmetics containing a nanoemulsion of a translucent formulation containing natural ceramide according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. The present invention may be implemented in many different forms and is not limited to the embodiments described herein. Hereinafter, the characteristics of the translucent nanoemulsion containing natural ceramide according to the present invention and the manufacturing method of customized cosmetics containing the same will be described in detail with reference to the attached drawings.

The translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention contains natural ceramide, functional peptide, ionic surfactant, fatty acid, and polyol as main ingredients, and may further include oil.

More specifically, the translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention contains 0.5 to 10% by weight of natural ceramide, 0.3 to 5.0% by weight of functional peptide, 0.1 to 4.0% by weight of ionic surfactant, and 0.1% by weight of fatty acid. ~ 4.0% by weight, 10 ~ 70% by weight polyol, and the remainder purified water. In addition, the translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention may further include 3.0 to 20% by weight of oil.

First, the ceramide of the present invention is a natural ceramide identical to the human body obtained through yeast fermentation, and is structurally different from similar ceramides made by synthesizing fatty acids and cholesterol, and has different physical properties such as melting point and hydrophobicity, so it is not a natural ceramide to be stabilized as a nanoemulsion. Ceramide is even more difficult.

These natural ceramides play an excellent role in preventing and improving atopic skin diseases by restoring the skin barrier function due to their skin affinity and strong moisturizing effect. Natural ceramide preferably contains 0.5 to 10.0 wt% of the total weight of the nanoemulsion, more preferably 3 to 9 wt%, and most preferably 5 to 8 wt%. There is a disadvantage in that it is difficult to show efficacy when the amount of natural ceramide added is less than 0.5% by weight. On the other hand, when the amount of natural ceramide added exceeds 10% by weight, the formulation stability is very unstable and precipitation occurs.

Functional peptides have excellent skin regenerative abilities, promoting wound healing, strengthening skin elasticity, and increasing the subcutaneous fat layer to prevent skin aging, thereby preventing and improving skin diseases. The functional peptide includes one or more selected from Copper Tripeptide-1 and Palmitoyl Tripeptide-1. In the present invention, it is more preferable that both Copper Tripeptide-1 and Palmitoyl Tripeptide-1 are added as the functional peptide.

These functional peptides are preferably contained in an amount of 0.3 to 5.0% by weight of the total weight of the nanoemulsion. If the amount of functional peptide added is less than 0.3% by weight, it is difficult to properly prevent and improve skin diseases, and if the amount of functional peptide added exceeds 5% by weight, viscosity may be weak and formulation may be difficult.

Ionic surfactants include Sodium Stearoyl Glutamate, Sodium Lauryl Glutamate, Potassium Cetyl Phosphate, Glyceryl Stearate Citrate, Distearyl Dimonium Chloride can be used alone or in combination of two or more selected from the group consisting of Distearyl Dimonium Chloride, and more preferably, Sodium Stearoyl Glutamate can be used.

These ionic surfactants are preferably contained in an amount of 0.1 to 4.0% by weight of the total weight of the nanoemulsion. If the amount of ionic surfactant added is less than 0.1% by weight, the stabilizing effect may be minimal when applied as a cosmetic formulation and particle formation may not occur, and if the amount of ionic surfactant added exceeds 4.0% by weight, skin irritation may occur. Since this occurs, it is desirable to adjust it appropriately within the above range.

The fatty acid may include one or more selected from lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, and behenic acid, and among these, oleic acid is most preferable.

These fatty acids are preferably added in an amount of 0.1 to 4% by weight of the total weight of the nanoemulsion. If the amount of fatty acid added is less than 0.1% by weight, it is difficult to form emulsified particles, and if the amount of fatty acid added is more than 4% by weight, skin irritation is likely to occur.

Polyol is used to improve the stability of the formulation by adjusting the refractive index of the formulation to increase transparency and lower the freezing point. It contains Glycerin, 1,3-Butylene Glycol, and Propylene Glycol. ), Pentylene glycol, propanediol, methyl propanediol, and dipropylene glycol.

The polyol preferably contains an amount of 10 to 70% by weight of the total weight of the nanoemulsion, and more preferably contains an amount of 20 to 60% by weight. If the amount of polyol added is less than 10% by weight of the total weight of the nanoemulsion, solubilization of high-content ceramide will be limited, and if the amount of polyol added exceeds 70% by weight, the content of emulsifier or lipid component will be reduced, making it difficult to maintain an appropriate mixing ratio. It cannot be contained.

Oils commonly used in this field include hydrocarbon-based oils, ester-based synthetic oils, mineral oils, vegetable oils, alkyl ester-based oils, and caprylic/capric triglyceride-based oils. Representative examples include hydrocarbon-based oils including squalane, hydrogenated poly(C6-14 olefin), and octyldodecanol; Cetyl ethylhexanoate, isopropyl myristate, isopropyl palmitate, ethylhexyl palmitate, isononyl isononanoate, C12~15 alkyl benzoate, glyceryl trioctanoate, octyldodecyl myristate, octyl palmitic acid. One type selected from the group consisting of ester-based synthetic oils containing tate and mixtures thereof may be used. In the present invention, it is more preferable to use a mixture of octyldodecanol and hydrogenated poly (C6-14 olefin) as the oil.

The oil preferably contains 3.0 to 20% by weight of the total weight of the nanoemulsion. If the amount of oil added is less than 3.0% by weight, it is difficult to dissolve natural ceramide in a high content, and if it is added in excess of 20% by weight, the amount of oil phase increases and the emulsifier content also increases, which may reduce the feeling of use and stability. there is.

In addition, the translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention may further include one or more of an emulsifier, an emulsion stabilizer, a thickener, and a preservative.

Emulsifiers play a role in maintaining a high feeling of use and emulsion stability. These emulsifiers may be added in an amount of 0.1 to 10% by weight of the total weight of the nanoemulsion, but are not limited thereto.

These emulsifiers include Glyceryl Stearate, Ceteareth-20, Ceteareth-12, Cetearyl Alcohol, Cetyl Palmitate, Glyceryl Stearate, PEG-100 Stearate, Polyhydroxystearic Acid, Lecithin, Ethylhexyl Palmitate, Isopropyl Myristate ( Isopropyl Myristate, Isostearic Acid, Polyglyceryl-3 Polyricinoleate, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone and PEG-10 Dimethicone.

Emulsion stabilizers are added to assist the emulsifying power of the emulsifier. This emulsion stabilizer may be added in an amount of 0.1 to 5.0% by weight of the total weight of the nanoemulsion, but is not limited thereto.

Emulsion stabilizers include Hydrogenated Lecithin, Inulin Lauryl Carbamate, Trimethylsiloxysilicate, Cyclopentasiloxane, Acrylate/Stearyl Acrylate/Dime. It may include one or more selected from Acrylates/Stearyl Acrylate/Dimethicone Methacrylate Copolymer and Dicaprylyl Carbonate, but is not limited thereto.

The thickener is not particularly limited as long as it is a known thickener ingredient applicable to cosmetic compositions. The thickener may be added in an amount of 0.01 to 3.0% by weight of the total weight of the nanoemulsion, but is not limited thereto.

These thickeners include Bis-PEG-18 Methyl Ether Dimethyl Silane, Disteardimonium Hectorite, Carbomer, Dimethicone, It may contain one or more selected from Dimethicone/Vinyl Dimethicone Crosspolymer, Dimethicone, Cyclopentasiloxane, and Polysilicone-11. You can.

Preservatives are substances added to stabilize the phase added to nanoemulsions and serve to increase the shelf life of cosmetic formulations. The preservative may be added in an amount of 0.05 to 2.0% by weight of the total weight of the nanoemulsion, but is not limited thereto.

These preservatives may include, but are not limited to, one or more selected from 1,2-hexanediol, ethylhexylglycerin, and pentylene glycol.

A preferred example of the translucent nanoemulsion containing natural ceramide according to the present invention described above is 33 to 43% by weight of glycerin, 2.0% by weight of pentylene glycol, 0.5 to 2.0% by weight of sodium stearoyl glutamate, and octyldodecane. 10 to 15% by weight of olefin, 4 to 9% by weight of hydrogenated poly (C6-14 olefin), 0.4 to 2.8% by weight of oleic acid, 1 to 4% by weight of functional peptide, 1 to 10% by weight of natural ceramide, and the remaining amount of The composition ratio includes purified water.

In particular, the optimal example of a translucent nanoemulsion containing natural ceramide according to the present invention is 43% by weight of glycerin, 2.0% by weight of pentylene glycol, 1.0% by weight of sodium stearoyl glutamate, and 10.0% by weight of octyldodecanol. , 4.0% by weight of hydrogenated poly (C6-14 olefin), 1.9% by weight of oleic acid, 3.0% by weight of functional peptide, 5.0% by weight of natural ceramide, and the remaining amount of purified water, which is Example 2 in [Table 5] described later. is the same as the content of

The translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention was stabilized by micronizing into nanoparticles by applying nanotechnology to pass the emulsifier through a high-pressure emulsifier maintained at ultra-high pressure.

Accordingly, the translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention has an average particle diameter of 40 to 80 nm, more preferably 45 to 75 nm, and most preferably 50 to 75 nm. It has an average particle size of If the average particle size of the nanoemulsion is less than 40 nm, it is difficult to achieve in the manufacturing process, and if the average particle size of the nanoemulsion exceeds 80 nm, the translucency may decrease and there is a possibility of precipitation, which may reduce formulation stability.

In this case, the translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention may contain 0.1 to 10% by weight of the active ingredient based on 100% by weight of the total weight of the entire cosmetic composition to be applied. It is not limited. If the amount of nanoemulsion added is less than 0.1% by weight based on 100% by weight of the total cosmetic composition, it may not affect the efficacy, and if the amount of nanoemulsion added exceeds 10% by weight based on 100% by weight of the total cosmetic composition. may make cosmetic formulations unstable.

Hereinafter, with reference to the attached drawings, a method for producing a translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention will be described.

Figure 1 is a process flow chart showing a method for producing a translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention.

As shown in Figure 1, the method for producing a nanoemulsion of a translucent formulation containing natural ceramide according to an embodiment of the present invention includes a first mixture forming step (S110), a second mixture forming step (S120), and a high pressure emulsification step (S130). ) includes.

Primary mixture formation

In the first mixture forming step (S110), the polyol, ionic surfactant, and purified water are measured and mixed, and then first heated and stirred to form the first mixture.

At this time, the polyol is glycerin, 1,3-Butylene Glycol, Propylene Glycol, Pentylene glycol, Propanediol, and methyl. It may contain one or more of propanediol (Methyl Propanediol) and dipropylene glycol (Dipropylene Glycol).

In addition, ionic surfactants include Sodium Stearoyl Glutamate, Sodium Lauryl Glutamate, Potassium Cetyl Phosphate, and Glyceryl Stearate Citrate. ) and distearyl dimonium chloride.

In this step, the first heating and stirring is preferably performed at a temperature of 60 to 90°C and a speed of 50 to 500 rpm for 10 to 180 minutes. If the first heating temperature is less than 60°C, the polyol and ionic surfactant may not be completely dissolved in purified water, and if the first heating temperature exceeds 90°C, there is a risk that the purified water may evaporate. Additionally, if the primary stirring speed is less than 50 rpm or the stirring time is less than 10 minutes, there is a risk that the polyol and ionic surfactant may not be completely dissolved in purified water. Conversely, if the stirring speed exceeds 500 rpm or the stirring time exceeds 180 minutes, it may act as a factor that only increases manufacturing costs without any further effect, making it uneconomical.

Secondary mixture formation

In the secondary mixture forming step (S120), natural ceramide, functional peptide, and fatty acid are weighed and mixed, and then secondary heating and stirring are performed to form a secondary mixture.

Here, the functional peptide may include one or more selected from Copper Tripeptide-1 and Palmitoyl Tripeptide-1.

Additionally, the fatty acid may include one or more selected from lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, and behenic acid.

In this secondary mixture formation step, additional oil may be added. At this time, the oil may be hydrocarbon-based oil, ester-based synthetic oil, mineral oil, vegetable oil, alkyl ester-based oil, and caprylic/capric triglyceride-based oil commonly used in this field.

In this step, the secondary heating and stirring is preferably performed at a temperature of 80 to 100°C and a speed of 500 to 2,500 rpm for 1 to 12 hours. If the secondary heating temperature is less than 80°C, it is difficult for each component in the secondary mixture to completely dissolve, and if the secondary heating temperature exceeds 100°C, it may cause problems that increase manufacturing costs due to excessive energy use.

Additionally, if the secondary stirring speed is less than 500 rpm or the stirring time is less than 1 hour, each component in the secondary mixture may not be completely dissolved, which may lead to difficulties in ensuring dispersibility. Conversely, if the stirring speed exceeds 2,500 rpm or the stirring time exceeds 12 hours, it may act as a factor that only increases manufacturing costs without any further effect, making it uneconomical.

During this secondary stirring, it is more preferable to carry out ultrasonic treatment at a frequency of 25 to 45 KHz and an output voltage of 10 to 20 W, in order to further improve the solubility of each component in the secondary mixture.

When applying ultrasonic waves, if the frequency is less than 25 KHz or the output voltage is less than 10 W, the cavitation effect due to the application of ultrasonic waves is minimal, making it difficult to properly demonstrate the effect of improving solubility. On the other hand, when the frequency of ultrasonic waves exceeds 45 KHz or the output voltage exceeds 20 W, it is undesirable because there is a risk that each component in the secondary mixture may be damaged due to excessive application of ultrasonic waves.

high pressure oil painting

In the high-pressure emulsification step (S130), high-pressure emulsification is performed by passing the primary and secondary mixtures through a high-pressure emulsifier and then cooled to form a translucent nanoemulsion.

In this step, high-pressure emulsification is preferably performed at a pressure of 300 to 1,500 bar at 30 to 70°C, and more preferably at a pressure of 700 to 1,300 bar at 40 to 60°C.

In addition, cooling can be carried out using a natural cooling method from 0 to 30°C.

As such, in this step, high-pressure emulsification is performed by passing the primary and secondary mixtures through a high-pressure emulsifier maintained at a pressure of 300 to 1,500 bar at 30 to 70°C. At this time, high pressure of 300 to 1,500 bar is applied at 30 to 70°C, converted to high speed, and this force is used to perform high pressure emulsification to transform micro particles into nanoparticles.

For this purpose, the high-pressure emulsifier forcibly injects the primary and secondary mixtures into a reaction chamber maintained at an ultra-high pressure of 300 to 1,500 bar under conditions of 30 to 70°C, thereby generating three forces such as collision, shear force, and cavitation within the reaction chamber. This was controlled to form particles with a nanoparticle size.

At this time, high-pressure emulsification is preferably passed through the high-pressure emulsifier repeatedly 1 to 7 times, more preferably 3 to 5 times. This means that it must be passed repeatedly at least 3 to 5 times within the reaction chamber of the high-pressure emulsifier to prevent collisions. This is because it is possible to further maximize shear force and cavitation, forming the most homogeneous and stable translucent nanoemulsion.

Accordingly, the translucent formulation nanoemulsion is micronized into nanoparticles by applying nanotechnology to pass it through a high-pressure emulsifier, and has an average particle diameter of 40 to 80 nm.

Hereinafter, with reference to the attached drawings, a method for manufacturing customized cosmetics containing a translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention will be described.

Figure 2 is a process flow chart showing a method for manufacturing customized cosmetics containing a translucent nanoemulsion containing natural ceramide according to an embodiment of the present invention.

As shown in Figure 2, the method for manufacturing customized cosmetics containing a nanoemulsion of a translucent formulation containing natural ceramide according to an embodiment of the present invention includes a step of acquiring skin measurement information and skin input information (S210), and skin diagnosis information. It includes a creation step (S220), a prescription data generation step (S230), and a customized cosmetics manufacturing step (S240).

In the skin measurement information and skin input information acquisition step (S210), the user's skin measurement information and skin input information are acquired using the user's terminal or smart diagnosis device.

In the skin diagnosis information generating step (S220), skin diagnosis information regarding the user's skin condition is generated based on skin input information and skin measurement information.

In the prescription data generation step (S230), prescription data for manufacturing customized cosmetics is generated based on skin diagnosis information.

In the customized cosmetics manufacturing step (S240), customized cosmetics are manufactured based on prescription data.

In this customized cosmetics manufacturing step (S240), the customized cosmetics may include a translucent nanoemulsion containing the above-described natural ceramide and a sub-cosmetic formulation containing functional ingredients. Accordingly, the nanoemulsion has an average particle diameter of 40 to 80 nm.

Here, the functional ingredients included in the sub-cosmetic formulation are one or a mixture of two or more selected from among moisturizing functional ingredients, wrinkle or elasticity improvement functional ingredients, whitening functional ingredients, pigmentation functional ingredients, skin soothing functional ingredients, and sebum or pore management functional ingredients. It is desirable to use what is already available.

The method for manufacturing customized cosmetics including a nanoemulsion of a translucent formulation containing natural ceramide according to the above-described embodiment of the present invention is to design a functional peptide material for improving the skin barrier, that is, antioxidant, anti-inflammatory and antibacterial peptide, and based on this, We have established a system that provides personalized cosmetics.

Specifically, the condition of an individual's skin is identified using a smart sensor that can be used quickly and easily, and the results of this analysis are used to design and synthesize functional peptide materials, which are important for the balance of functional peptides and the skin's oil and moisture. We aim to provide customized cosmetics that are effective in improving the skin barrier by creating a translucent nanoemulsion using nanoemulsion technology that can add high concentrations of ceramide.

In other words, it is a technology to design and synthesize various functional peptide materials using particles with functional groups immobilized on polymer resin for cosmetics consumers suffering from skin barrier breakdown. In addition, it has a more efficient skin barrier improvement effect by combining functional peptides with antioxidant, anti-inflammatory and antibacterial properties. Functional peptides are manufactured into a nanoemulsion formulation by adding high concentration of ceramide, and then personalized cosmetics are manufactured based on this.

We design functional peptides that can relieve inflammation and itching caused by inflammation and bacterial infection from bio-materials that can combine countless peptides, and synthesize peptide materials with active ingredients that have antioxidant, anti-inflammatory, and antibacterial properties according to each individual's skin condition and customize them. We will manufacture skin barrier improvement cosmetics. We synthesize customized peptide bio-materials that show effective improvement effects on various factors that break down the skin barrier, and combine the synthesized functional peptide materials with ligands and peptides that can improve skin absorption to achieve a more effective skin barrier improvement effect. It can be induced.

Generally, one of the main phenomena that occurs when the skin barrier is destroyed is a decrease in ceramide content. To improve this phenomenon, it is necessary to develop cosmetic formulation technology with high ceramide content. However, due to its low solubility in aqueous phase, currently Formulation technology that adds less than 1% by weight is common.

On the other hand, in the present invention, a high content of 1 to 10% by weight of ceramide is stably dissolved using nanoemulsion technology to manufacture customized cosmetics.

In this way, the translucent nanoemulsion containing natural ceramide according to the present invention has excellent stability and can be stably formulated into customized cosmetics by mixing with sub-cosmetic formulations.

Sub-cosmetic formulations contain functional ingredients according to the individual's skin condition.

At this time, the sub-cosmetic containing the functional ingredient is, for example, a formulation containing one or more functional ingredients, and may be manufactured by the nanoemulsion manufacturing method using a high-pressure emulsifier (Micrifluidizer) described in the present invention. The base formulation is a nanoemulsion and can be a water-soluble base formulation such as cream, serum, or essence.

In an embodiment of the present invention, the base formulation is a master formulation for producing a final cosmetic by mixing one or two types of sub-cosmetic formulations containing functional ingredients, and the master formulation does not contain a surfactant, solubilizer, or stabilizer. may not be present, and may contain a water-soluble thickener to keep the functional emulsion contained in the sub-cosmetic formulation stable.

For example, the base formulation contains purified water, isopentyldiol, glycerin, 1,2-hexanediol, trehalose, butylene glycol, betaine, dipotassium glycyrrhizate, acrylate/C10-30. It may be composed of alkylacrylate cross polymer, arginine, disodium EDTA, and caprylyl glycol. Mixing the base formulation and the sub-functional cosmetic formulation can be done by mixing using a syringe or other metering device, or by pouring the sub-functional cosmetic contents directly into the base formulation.

For example, information about the consumer's skin such as pore distribution, pore size, degree of pigmentation, dead skin cells, atopic dermatitis, moisture and oil content, and elasticity, as well as collagen decomposition ability and hyaluronic acid as age-related traits based on the consumer's genetic polymorphisms. Synthetic ability, free radical removal ability (antioxidant ability), DNA repair ability, cell regeneration ability and estrogen level, inflammation resistance as trait of acne, contact dermatitis and allergic dermatitis, photoaging and pollutant resistance as UV sensitivity, melanin synthesis, freckles. , collect comprehensive information such as analysis results of genetic factors related to blemishes and pollutant metabolism, create a prescription tailored to the characteristics of the skin, and then mix sub-cosmetic formulations according to the prescription to create personalized cosmetics just for that user. can be manufactured.

In addition, according to the manufacturing method of customized cosmetics of the present invention, the base formulation of the cosmetic and each effective ingredient of the sub-cosmetic formulation to provide functionality are evenly dispersed in the form of a W/O emulsion on the base formulation, so that the effective ingredients It is possible to manufacture personalized cosmetics that are physically and chemically separated from the formulation and do not negatively affect the stability of the formulation even if sub-functional cosmetic formulations are mixed according to skin diagnosis results.

The manufacturing process of cosmetics involves maintaining the physical and chemical balance of various ingredients such as active ingredients, thickeners, moisturizers, and surfactants, and then going through a testing process to evaluate the activity, properties, and quality of the active ingredients according to changes over time. At this time, each manufactured formulation is manufactured by adding oil-based, water-based raw materials selected according to the design purpose, manufacturing the formulation differently to maximize the stability and efficacy of the formulation, and then completing various tests. If other ingredients are added to this formulation, the completeness of the formulation must be re-evaluated through additional testing.

The base formulation and sub-cosmetic formulation, which are a mixture of customized cosmetics manufactured by the manufacturing method of the present invention, share most of the components except for the effective raw materials to demonstrate unique efficacy, and separate stability tests are performed for each. It was verified.

However, it is virtually impossible for two detailed functional products to have perfect homogeneity in terms of physical properties, chemical composition, emulsification conditions, preservation of active ingredients, and efficacy optimization conditions due to differences in efficacy raw materials, and all components of the two products are mixed. The resulting formulation becomes a third formulation with different physical properties and chemical composition from the base formulation and sub-cosmetic formulation.

In the case of these third formulations, there may be a negative impact on the stability and activity of the active ingredients contained in the base formulation and sub-cosmetic formulation, as well as the emulsion stability of the formulation, so it is necessary to evaluate the formulation through a separate test.

If customized cosmetics that are intended to be provided to consumers by mixing each formulation are manufactured using existing cosmetic manufacturing methods, the risk of reducing stability and efficacy increases, and as the number of detailed functional products added increases, there is a possibility that the formulation may become unstable. increases rapidly.

The manufacture of cosmetic formulations involves forming a fine nanoemulsion through an emulsification process of two types of unmixed oil-based and water-based ingredients or forming a micelle structure through a solubilization process so that they coexist in a thermodynamically stable manner in the formulation. go through the process of At this time, an emulsifier with various HLB (Hydrophilic-Lipophilic Balance) values is selected depending on the type of raw material used and the type of formulation, and the amount of emulsifier used varies depending on the amount of fat-soluble raw material used.

However, even in a stable emulsified or solubilized state, physical changes (temperature, pressure, mechanical stress, solar irradiation, microwaves) and chemical changes (changes in the amount of fat-soluble components, gas contact (oxygen), metal components, and salt) that can change the stability of the formulation. Change in amount, change in pH, etc.) or microbial contamination (yeast, bacteria, mold, virus, etc.) may destroy the internal physicochemical balance, causing destruction of the formulation such as phase separation.

Therefore, in the case of customized cosmetics using existing manufacturing methods, if the composition and content of the base formulation changes during the mixing process, the thermodynamic stability of the emulsified state decreases, increasing the possibility of destruction of the formulation.

On the other hand, in the case of customized cosmetics manufactured by the manufacturing method according to the present invention, even if the base formulation of the nanoemulsion is mixed, the base formulation and the water-soluble and fat-soluble active ingredients are physically separated during the mixing process of "A + B = C", Even if functional cosmetics are mixed, the impact on the composition of the base formulation can be minimized, minimizing factors that may change the stability of the formulation. This is possible because the nanoemulsion formulation has been stabilized.

These customized cosmetics can determine the customer's skin type, skin condition, skin concerns, skin tone, grade, etc. through skin diagnosis. For example, through skin diagnosis, the size and/or number of pores, degree and/or size of trouble, presence of pigmentation, size and/or depth of wrinkles, elasticity, sensitivity, degree of exposure to ultraviolet rays, amount of sebum secretion, oil and water balance, and dead skin cells. , skin tone, left-right symmetry, cleansing or color makeup status, exposure to harmful environments, and level of skin stress due to cosmetics usage habits, etc. are determined.

Building a personalized classification system uses skin information provided by smart diagnostic devices. In order to prepare (divide and mix) customized cosmetics, it is necessary to select cosmetic formulations and raw materials suitable for the customer's skin type, so a customized classification system was established according to the characteristics of each skin type as shown in [Table 1] below.

skin type characteristic dry The secretion of sebum and sweat is low, so the skin surface is dry and dull. As the skin ages, the secretion of sebum and sweat decreases, making the skin drier.
Skin prone to fine wrinkles due to lack of moisture in the skin oily The face becomes shiny due to high sebum secretion, pores are large, and black acne appears in the T-zone (forehead and around the nose) where sebum secretion is high.
The natural sebum film is well formed and the skin is moisturized. Combination This skin type is both oily and dry. There is a T-zone with high sebum secretion and a U-zone with low sebum secretion. The T-zone is shiny and has acne, while the U-zone (cheeks, around the mouth, around the eyes) lacks moisture. to dry neutral The skin has normal secretion of sebum and sweat, the skin physiological function is normal, the skin is clean and the surface is smooth.
The skin is elastic, has a bright complexion, and pores are not noticeable.

Skin condition is generally measured by measuring skin moisture, oil, moisture evaporation amount, melanin amount, erythema amount, color, sensitivity, etc. to evaluate skin condition as shown in [Table 2] below.

Metrics measurement method skin moisture Measures the amount of moisture in the skin through electroconductivity Skin elasticity Measures the extent to which the skin returns to its original state after applying negative pressure skin oil After attaching the cartridge film to the skin for a certain period of time, measure the amount of skin oil through the transparency of the cartridge film. skin surface Observe fine wrinkles, thick wrinkles, roughness, dead skin cells, pore size, dark circles, pigmentation, etc. through a microscope, etc. melanin The amount of melanin in the skin is measured and expressed as a number. erythema Measures skin redness (hemoglobin) and expresses it as a number skin pH Measures the acidity of the skin and displays it as pH dry skin It measures transepidermal water loss (TEWL), which is the amount of moisture evaporating from the skin, and can be used as a value to evaluate skin barrier function.

Personalized cosmetics segmentation formulation technology has been secured, and the cosmetic formulation classification and characteristics are shown in [Table 3] below.

Formulation characteristic product emulsion formulation
Emulsification:
Cream type, lotion type A formulation in which one of two immiscible liquids is dispersed in the other liquid using an emulsifier (surfactant) in the form of fine particles. Cream, emulsion (lotion),
Nutrients (essence, serum) Solubilized formulation
Solubilization:
liquid A formulation that uses a solubilizer (surfactant) to dissolve substances with very low water solubility (ex. oil, fragrance) beyond the solubility level. Toner (skin lotion, toner),
mist, perfume Emulsified dispersion formulation
Dispersion:
Creamy Formulation using a dispersion medium (ex. pigment) dispersed in an emulsified dispersoid (ex. emulsion) BB cream, foundation, makeup base, mascara solidified formulation
Solidification:
elegance Formulation made by dispersing pigment in oil and wax and solidifying it Lipstick, lip balm, concealer Powder mix formulation
Powder mixing:
powder form Formulation that mixes pigment, pearl, binder (silicone oil, ester oil), and fragrance (however, face powder is not solidified) Face powder, compact,
eye shadow Surfactant mixture formulation
Surface mixing:
liquid Formulation manufactured by mixing anionic, cationic, amphoteric, nonionic surfactants, etc. Shampoo, conditioner, rinse,
Body wash, hand sanitizer

The research and development and prescription of segmented formulations suitable for personalized classification established the development and prescription of three classification formulations of cream/serum/cleansing foam based on a customized cosmetic nanoemulsion base formulation containing a high content of natural ceramide.

The three classification formulations were each individually tailored to each skin type, as shown in [Table 4] below.

Formulation classification Skin type classification cream dry oily Combination neutral serum dry oily Combination neutral Cleansing Foam dry oily Combination neutral

The translucent nanoemulsion and manufacturing method containing natural ceramide according to the above-described embodiment of the present invention and the custom cosmetic manufacturing method including the same improve the stability of active ingredients such as functional peptides and natural ceramide contained in the internal droplets. In addition, the encapsulation efficiency of the active ingredient is increased, and a formulation with improved stability and uniform droplet size can be manufactured.

In addition, a nanoemulsion of a translucent formulation containing natural ceramide and a method of manufacturing the same, as well as a method of manufacturing customized cosmetics including the same, apply a nanoemulsion of a translucent formulation containing natural ceramide to the production of customized cosmetics, so that it can be tailored to the consumer's skin type or constitution. The stability of the corresponding functional ingredients can be improved, and the number of possible personalized prescriptions can be easily increased.

Example

Hereinafter, the configuration and operation of the present invention will be described in more detail through preferred embodiments of the present invention. However, this is presented as a preferred example of the present invention and should not be construed as limiting the present invention in any way.

Any information not described here can be technically inferred by anyone skilled in the art, so description thereof will be omitted.

1. Preparation of translucent formulation nanoemulsion

Nanoemulsions of a translucent formulation containing natural ceramide according to Examples 1 to 3 and Comparative Examples 1 to 3 were prepared at the composition ratios shown in Table 5.

To prepare this nanoemulsion, purified water, glycerin, and sodium stearoyl glutamate were measured and mixed using a vacuum tank, and then completely dissolved using a paddle mixer at 80°C at 100 rpm to prepare the first mixture.

Next, hydrogenated poly(C6-14 olefin), octyldodecanol, ceramide, and oleic acid were dissolved in a separate dissolution tank at 85°C, added to a vacuum tank, and stirred at 1,000 rpm to prepare a secondary mixture.

Next, since the liquid in the dissolved state exists unstable in the form of an irregular vesicle, high-pressure emulsification is performed by passing the first and second mixtures through a high-pressure emulsifier to homogeneously and stably transform them into fine particles to prepare a nanoemulsion. did. At this time, high-pressure emulsification was repeated four times through the reaction chamber of a high-pressure emulsifier maintained at a pressure of 1,200 bar at 60°C.

division Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 glycerin 43.0 43.0 33.0 43.0 43.0 33.0 Pentylene glycol 2.0 2.0 2.0 2.0 2.0 2.0 sodium
Stearoyl
glutamate 0.5 1.0 2.0 - 0.5 - octyldodecanol - 10.0 15.0 - - 15.0 Hydrogenated
Poly(C6-14 olefin) 9.0 4.0 4.0 8.0 9.0 4.0 Oleic acid 0.4 1.9 2.8 0.4 2.8 ceramide 1.0 5.0 10.0 1.0 1.0 10.0 functional peptide 1.0 3.0 4.0 1.0 2.0 3.0 Purified water Bal. Bal. Bal. Bal. Bal. Bal. Appearance translucent liquid translucent liquid translucent liquid separated translucent liquid separated M/F processing ○ ○ ○ ○ ○ ○

In Table 5, copper peptide-1 and palmitoyl tripeptide-1 were used as functional peptides. Here, Comparative Examples 1 and 3 were separated as unstable emulsions due to not adding sodium stearoyl glutamate, the main emulsifier.

2. Stability test of nanoemulsion over time

Samples were collected from the nanoemulsions prepared according to Examples 1 to 3 and Comparative Examples 1 to 4, and the average particle size of the nanoemulsion and stability of the nanoemulsion over time were confirmed, and are shown in [Table 7] below.

At this time, to measure the average particle size of the nanoemulsion, it was measured using a nanoparticle analyzer (SZ-100Z, Horiba) that can measure particle size and zeta potential using dynamic light scattering characteristics. In addition, in order to determine the stability of the nanoemulsion over time, the samples prepared in Examples 1 to 3 and Comparative Examples 1 to 3 were subjected to 4 cycles at room temperature (25°C), refrigeration (5°C), and high temperature (40°C). Weekly discoloration, separation, suspension, and precipitation were evaluated by visually observing and recording. In Table 7, ○: good, X: separation, ▽: off-flavor, ▽: suspension and precipitation.

division particle size Nanoemulsion change over time by temperature Room temperature (25℃) Refrigeration (5℃) High temperature (40℃) 1 week 2 weeks 4 weeks 1 week 2 weeks 4 weeks 1 week 2 weeks 4 weeks Example 1 52.9 ○ ○ ○ ○ ○ ○ ○ ○ ○ Example 2 74.8 ○ ○ ○ ○ ○ ○ ○ ○ ○ Example 3 63.7 ○ ○ ○ ○ ○ ○ ○ ○ ○ Comparative Example 1 - X X X X X X X X X Comparative Example 2 123.0 ○ ○ ○ ○ ○ ○ ○ ○ ○ Comparative Example 3 - ▽ ▽ ▽ ▽ ▽ ▽ ▽ ▽ ▽

Looking at the results in Tables 5 and 6, as can be seen from the comparison between Example 1 and Comparative Examples 1 and 2, Comparative Example 1, which did not contain sodium stearoyl glutamate, showed a separation phenomenon immediately after emulsification. In Comparative Example 2, a relatively stable nanoemulsion was formed with an average particle size of 123.0 nm, but when observed in refrigeration for 4 weeks, a suspension phenomenon occurred, indicating an unstable state.

On the other hand, Example 1 formed a very stable nanoemulsion with an average particle size of 52.9 nm, and the stability was observed for 4 weeks and all were stable.

In addition, as can be seen from the comparison between Example 3 and Comparative Example 3, Comparative Example 3, which contained a high content of ceramide (10% by weight) and deleted sodium stearoyl glutamate, showed the same results as Comparative Example 1.

Based on the particle analysis results of Examples 1 to 3 and Comparative Examples 1 to 3 and the stability results at each temperature condition, when sodium stearoyl glutamate was used alone as a surfactant, the average particle size immediately after manufacturing was relatively good. Over time, suspension or precipitation occurred at low temperatures. When mixed with fatty acids such as oleic acid, the particles in the inner phase were formed very small and the particle size distribution was uniform, making it possible to produce a nanoemulsion with excellent long-term stability.

3. Manufacturing of sub-cosmetics containing functional ingredients

A sub-cosmetic formulation containing functional ingredients was prepared using the raw materials and composition ratios shown in Table 7 below. At this time, the sub-cosmetic formulation containing functional ingredients was mixed with the nanoemulsion containing high content of ceramide prepared according to Example 3 to prepare customized cosmetics.

division ingredient Composition ratio (% by weight) Example 4 Functional ingredients for moisturizing solvent Purified water Remaining amount (to 100) functional ingredients Glycerin, hydrolyzed glycosaminoglycan 10 first auxiliary additive Butylene glycol 5 propanediol 5 1,2-hexanediol 2 Example 5 Functional ingredients for improving wrinkles or elasticity solvent Purified water Remaining amount (to 100) functional ingredients Peptide, collagen extract 10 first auxiliary additive Butylene glycol 5 propanediol 5 1,2-hexanediol 2 Example 6 Functional ingredients for whitening solvent Purified water Remaining amount (to 100) functional ingredients Nasturtium extract 10 first auxiliary additive Butylene glycol 5 propanediol 5 1,2-hexanediol 2 Example 7 Functional ingredients for pigmentation solvent Purified water Remaining amount (to 100) functional ingredients Milky white bark extract, licorice extract, tocopheryl acetate 10 first auxiliary additive Butylene glycol 5 propanediol 5 1,2-hexanediol 2 Example 8 Functional ingredients for skin soothing solvent Purified water Remaining amount (to 100) functional ingredients Aesculus hippocastanum (horse chestnut) extract 10 first auxiliary additive Butylene glycol 5 propanediol 5 1,2-hexanediol 2 Example 9 Functional ingredients for sebum or pore management solvent Purified water Remaining amount (to 100) functional ingredients Lens esculenta (lentil) seed extract 10 first auxiliary additive Butylene glycol 5 propanediol 5 1,2-hexanediol 2

As shown in Table 7, a sub-cosmetic formulation containing functional ingredients can be mixed with a nanoemulsion containing a high content of ceramide prepared according to Example 2 to form a stable customized cosmetic product.

In this way, a base composition containing purified water, natural ceramide, oil, thickener, surfactant and additives, a mixed functional composition containing purified water, mixed functional ingredients and a first auxiliary additive, and purified water, a second complex natural extract, water-soluble silicon, A booster composition containing a nanoparticle mixture and a neutralizing agent is included, and the mixed functional ingredients include moisturizing functional ingredients, wrinkle or elasticity improvement functional ingredients, whitening functional ingredients, pigmentation functional ingredients, skin soothing functional ingredients, and sebum or pore management functional ingredients. Customized cosmetics can be manufactured by including one selected first functional ingredient and another selected second functional ingredient.

Although the examples and comparative examples of the present invention have been described in detail as described above, the scope of the rights of the present invention is not limited thereto, and the scope of the rights of the present invention extends to the scope substantially equivalent to the examples of the present invention. .

S110: First mixture formation step
S120: Secondary mixture formation step
S130: High pressure emulsification step
S210: Obtaining skin measurement information and skin input information
S220: Step of generating skin diagnosis information
S230: Prescription data generation step; and
S240: Customized cosmetics manufacturing steps

Claims (9)

Glycerin 33 to 43% by weight, pentylene glycol 2.0% by weight, sodium stearoyl glutamate 0.5 to 2.0% by weight, octyldodecanol 10 to 15% by weight, hydrogenated poly (C6-14 olefin) 4 to 9% by weight %, 0.4 to 2.8% by weight of oleic acid, 1 to 4% by weight of functional peptide, 1 to 10% by weight of natural ceramide, and the remaining amount of purified water.
The functional peptide is added together with Copper Tripeptide-1 and Palmitoyl Tripeptide-1,
A translucent formulation nanoemulsion containing natural ceramide, which is micronized into nanoparticles by applying nanotechnology to pass through a high-pressure emulsifier and has an average particle diameter of 40 to 80 nm. delete delete delete delete (a) forming a primary mixture by weighing and mixing polyol, ionic surfactant, and purified water, then primary heating and stirring for 10 to 180 minutes at a speed of 50 to 500 rpm at 60 to 90°C;
(b) forming a secondary mixture by weighing and mixing natural ceramides, functional peptides, and fatty acids, and then performing secondary heating at 80 to 100°C at a speed of 500 to 2,500 rpm for 1 to 12 hours; and
(c) performing high-pressure emulsification of the primary and secondary mixtures through a high-pressure emulsifier and then cooling to form a nanoemulsion of a translucent formulation,
In step (b), during the secondary stirring, ultrasonic treatment is performed at a frequency of 25 to 45 KHz and an output voltage of 10 to 20 W,
After step (c), the nanoemulsion of the translucent formulation contains 33 to 43% by weight of glycerin, 2.0% by weight of pentylene glycol, 0.5 to 2.0% by weight of sodium stearoyl glutamate, 10 to 15% by weight of octyldodecanol, It contains 4 to 9% by weight of hydrogenated poly (C6-14 olefin), 0.4 to 2.8% by weight of oleic acid, 1 to 4% by weight of functional peptide, 1 to 10% by weight of natural ceramide, and the remaining amount of purified water.
The functional peptide is added together with Copper Tripeptide-1 and Palmitoyl Tripeptide-1,
The nanoemulsion of the translucent formulation is a nanoemulsion of the translucent formulation containing natural ceramide, which is atomized into nanoparticles by applying nanotechnology that passes through a high-pressure emulsifier, and has an average particle diameter of 40 to 80 nm. Manufacturing method. According to clause 6,
In step (c) above,
The high pressure emulsification is
A method of manufacturing a nanoemulsion of a translucent formulation containing natural ceramide, characterized in that it is carried out at a pressure of 300 to 1,500 bar under conditions of 30 to 70°C. (a) obtaining the user's skin measurement information and skin input information using the user's terminal or smart diagnostic device;
(b) generating skin diagnosis information about the user's skin condition based on the skin input information and skin measurement information;
(c) generating prescription data for manufacturing customized cosmetics based on the skin diagnosis information; and
(d) manufacturing customized cosmetics based on the prescription data,
The customized cosmetics include a translucent nanoemulsion containing natural ceramide and a sub-cosmetic formulation containing functional ingredients,
The nanoemulsion of the translucent formulation contains 33 to 43% by weight of glycerin, 2.0% by weight of pentylene glycol, 0.5 to 2.0% by weight of sodium stearoyl glutamate, 10 to 15% by weight of octyldodecanol, and hydrogenated poly (C6- 14 olefin) 4 to 9% by weight, oleic acid 0.4 to 2.8% by weight, functional peptide 1 to 4% by weight, natural ceramide 1 to 10% by weight, and the remaining amount of purified water.
The functional peptide is added together with Copper Tripeptide-1 and Palmitoyl Tripeptide-1,
A method for manufacturing customized cosmetics comprising a nanoemulsion of a translucent formulation containing natural ceramide, wherein the nanoemulsion has an average particle diameter of 40 to 80 nm. According to clause 8,
The functional ingredients are
Contains natural ceramide, which is characterized by using one or a mixture of two or more selected from moisturizing functional ingredients, wrinkle or elasticity improving functional ingredients, whitening functional ingredients, pigmentation functional ingredients, skin soothing functional ingredients, and sebum or pore management functional ingredients. Method for manufacturing customized cosmetics containing nanoemulsions in a translucent formulation.