KR100844275B1 - Cosmetic Composition for Preventing Skin Aging Comprising the Morinda citrifolia Extract As Active Ingredient - Google Patents

Abstract

The present invention is Morinda citrifolia ) relates to a cosmetic composition for preventing skin aging containing the extract as an active ingredient. The cosmetic composition of the present invention enhances the synthesis of collagen, a protein constituting the dermal matrix, and enhances the expression of integrins involved in the interaction between the matrix and the cells of the dermis, effectively improving skin wrinkles and skin elasticity and preventing skin aging. It can be usefully used.

Noni, skin aging, skin wrinkles, skin elasticity, cosmetics

Description

Cosmetic composition for preventing skin aging containing Noni extract as an active ingredient {Cosmetic Composition for Preventing Skin Aging Comprising the Morinda citrifolia Extract As Active Ingredient}

The present invention relates to a cosmetic composition for preventing skin aging containing noni extract as an active ingredient.

The primary function of the skin is to protect the human body from external stimuli such as temperature, humidity and ultraviolet light. However, when the skin is exposed to external stimuli such as strong ultraviolet rays, stress, and malnutrition, the skin may age, such as wrinkle formation, loss of elasticity, and keratinization. Collagen and elastic fibers (elastin) present in the dermal layer of the skin structure is the main protein that controls the elasticity of the skin. The biosynthesis of collagen fibers is affected internally and externally. Internally, natural aging (reduction of estrogens) causes a decrease in cellular activity resulting in a decrease in collagen fibers. External factors include free radicals generated by excessive irradiation of UV rays and stress, which react with the -SH group of proteins to inhibit the activity of enzymes or to degrade collagen and elastin (Matrix Metalloproteinases: MMPS). ) Increases the expression of collagenase, causing aging that reduces wrinkles and elasticity of the skin. In particular, over-irradiation of UV light may cause wrinkles, thickening of the skin, sagging of the skin, loss of elasticity, roughness of the skin, dryness of the skin, and skin stains that occur as skin tissue gradually changes with age. It is known to accelerate.

Currently, cosmetics or skin protectants containing various skin protection ingredients such as retinol, retinoid, vitamin C, flavonoids and tocopherol have been developed to suppress or slow down the progression of skin. In the final formulation, the potency is low, the efficacy is mild, and the skin irritation has a serious problem.

On the other hand, Korean Patent Application No. 1997-60849 discloses a skin anti-aging cosmetic composition containing a serine of retinol, alpha hydroxy acid, vitamins, in particular beta hydroxy acid, and Korea Patent Application No. 1998-18636 An anti-aging cosmetic composition comprising an amino polymer as an active ingredient is disclosed. In addition, Korean Patent Application No. 1994-7002880 discloses a cosmetic composition synergistically as an antioxidant containing ginkgo extract and at least one polyphenol derivative, and Korean Patent Application No. 1996-69236 discloses L-2- Disclosed is a composition for preventing skin aging comprising an oxothiazolidine-4-carboxylic acid derivative.

Throughout this specification, numerous patent documents are referenced and their citations are shown in parentheses. The disclosure of the cited patent documents is incorporated herein by reference in their entirety, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained.

Accordingly, the present inventors overcome the problem that existing skin anti-aging cosmetics developed to suppress skin aging or to slow the progression rate have a lower titer in the final formulation, or the efficacy thereof is mild and the skin irritation is severe. As a result of many studies, Noni extract has an excellent effect on improving skin wrinkles and skin elasticity by enhancing collagen synthesis and integrin expression of fibroblasts, and it has excellent formulation stability and induces skin irritation of cosmetics containing it. The present invention was completed by confirming that no.

Therefore, an object of the present invention is to provide a cosmetic composition for improving skin wrinkles containing noni extract as an active ingredient.

In addition, an object of the present invention is to provide a cosmetic composition for improving skin elasticity containing a noni extract as an active ingredient.

Other objects and advantages of the present invention will become apparent from the following detailed description and claims.

According to one aspect of the invention, the present invention provides a cosmetic composition for improving skin wrinkles containing noni extract as an active ingredient.

In addition, according to another aspect of the present invention, the present invention provides a cosmetic composition for improving skin elasticity containing a noni extract as an active ingredient.

The present inventors prepared extracts using a variety of extraction methods using a number of natural products as a raw material, the result of performing the task of selecting a material excellent in integrin expression enhancement and collagen synthesis promoting effect Noni ( Morinda citrifolia ) extract was found to be the most suitable for the purpose of the present invention described above.

Noni ( Morinda citrifolia ) included as an active ingredient in the cosmetic composition of the present invention is a medicinal plant native to the Moroccan Islands of Indonesia. Since about 6000 years ago, fruits and leaves have been used for food and medicinal purposes, and roots and stems have been used for dyeing. In Indonesia, it is called Menkd, Pache, and Diva. It is effective for all kinds of diseases. It is still used as a traditional medicine.

Noni extract, an active ingredient of the cosmetic composition of the present invention, has an effect of promoting the synthesis of collagen, a protein constituting the matrix of the dermis of the skin, and has an effect of enhancing the expression of integrin involved in the interaction between the matrix and the cells of the dermis. It improves skin wrinkles and skin elasticity.

In the present invention, the skin cell refers to a cell present in the skin, and is preferably a fibroblast. The protein includes a protein necessary for structure formation and function of skin cells. Preferably collagen, elastin and integrin.

In the present invention, noni extract means that obtained by extracting from various organs or parts (eg leaves, flowers, fruits, stems, roots, branches and shells, etc.) of the noni, preferably extracts obtained from the fruit of noni it means.

Noni extracts of the present invention may be prepared according to conventional methods known in the art, i.e., under conventional conditions of temperature and pressure, using conventional solvents.

Noni extract, an active ingredient of the composition of the present invention, is extracted using a solvent selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, chloroform and 1,3-butylene glycol. Preference is given to more preferred ethyl alcohol, butanol or methanol, even more preferably ethyl alcohol. The ethyl alcohol is preferably 70% ethyl alcohol. A suitable amount of the extraction solvent is 1-10 times the dry weight of Noni, more preferably 5-8 times, most preferably 6 times.

Noni extract of the present invention is prepared by a process comprising the following steps:

(a) adding to the dry noni a solvent selected from the group consisting of 1-10 times water, 1-4 anhydrous or hydrous lower alcohols, acetone, ethyl acetate, chloroform and 1,3-butylene glycol;

(b) extracting the solvent-added noni of step (a) at 4-40 ° C. for 1-15 days;

(c) filtering the extract of step (b) followed by aging for 3-10 days at 1-10 ° C., followed by filtration; And

(d) drying the filtrate of step (c) with a rotary evaporator.

In this case, when 1,3-butylene glycol is used as the extraction solvent, it is difficult to dry using a rotary depressurization evaporator, and thus, after performing the extraction step (b), the drying loss is adjusted to 1% (w / v).

According to a specific embodiment of the present invention, the above extraction process is carried out as follows: First, the raw Noni fruit is washed, dried and powdered, and then 70% ethyl alcohol is 6 times the volume ratio of the dry weight of the Noni fruit. Extracted for 4 days at 4-40 ℃ and then aged for 5 days at 3-5 ℃ and filtered. Subsequently, the filtrate was dried at a rotary decompression evaporator at 65 ° C. to prepare a noni extract.

According to another embodiment of the present invention, the noni extract is prepared by a supercritical fluid extraction method. The supercritical fluid extraction method is as follows: Noni is washed with purified water, dried and crushed, and then 100 grams of the sample is placed in a supercritical fluid extractor (Jasco, Japan) and a liquid chromatography pump (Supercritical fluid chromatograph, Jasco, Japan) using pure carbon dioxide and a cosolvent (such as a mixture of alcoholic solvent, alcohol, and non-polar solvent squalene in a 1: 1 ratio, etc.) to make a supercritical state at a temperature of 80 ° C and a pressure of 300 atm. The extract is received in a 10 ml glass test tube for up to 40 minutes every 4 minutes.

On the other hand, the noni extract of the present invention includes not only the extract by the above-described extraction method, but also the extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). Fractions are also construed as being included in the Noni extract of the present invention.

Noni extract of the present invention may be prepared in a powder state by an additional process such as distillation under reduced pressure and freeze drying or spray drying.

In a preferred embodiment of the present invention, the content of noni extract is 0.000001 to 15.0% by weight, more preferably 0.0001 to 10.0% by weight, most preferably 0.001 to 7.0% by weight based on the total cosmetic composition. If the content of noni extract is less than 0.000001% by weight, no obvious anti-aging effect, especially wrinkle improvement and skin elasticity improvement effect, cannot be expected. If the content of noni extract exceeds 15.0% by weight, the effect of increasing the content is obvious. There is no increase in, and there is a problem in skin irritation and product stability.

Ingredients included in the cosmetic composition of the present invention include ingredients conventionally used in cosmetic compositions in addition to Morinda citrifolia extract as an active ingredient, for example, such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings Phosphorus aids, and carriers.

Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like, but are not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The cosmetic composition of the present invention has the use of skin anti-aging through improving skin wrinkles and improving skin elasticity. As used herein, the term 'anti-aging of the skin' has a meaning encompassing comprehensively the prevention and treatment of skin aging. The cosmetic composition of the present invention promotes the synthesis of proteins constituting the matrix of the dermis, especially collagen, and enhances the expression of integrins involved in the interaction between the matrix and the cells of the dermis, thereby improving skin wrinkles and skin elasticity. This is indicated in the following examples. Therefore, the anti-aging of the skin, which is the use of the present invention, is interpreted to include the improvement of wrinkles, the moisturizing ability, the skin protection by the antioxidant effect, and the improvement of skin elasticity.

In addition, the cosmetic composition of the present invention does not have problems such as skin irritation induced or instability of the formulation appearing in the existing anti-aging cosmetic composition.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .

Example  1: Preparation of Noni Extract

After washing with purified water and crushing the dried Noni fruit 100g, it was put in 1.2 ℓ of water and extracted for 5 days at 4-40 ℃, filtered with 300 mesh filter cloth, left for 5 days at low temperature 3-5 ℃, aged and then with filter paper Filtered. The filtrate was dried at 65 ° C. with a rotary immersion evaporator to obtain a dry weight of 25.13 g of noni extract.

Example  2-19: Preparation of Noni Extract

A noni extract was obtained by extracting in the same manner as in Example 1, except that the extracting solvent of Table 1 was used.

Example 2-19 Noni Extract extract Extraction solvent Dry weight of the final extract (unit: g) Example 2 10% ethanol 21.8 Example 3 20% ethanol 21.9 Example 4 30% ethanol 22.2 Example 5 40% ethanol 23.3 Example 6 50% ethanol 24.1 Example 7 60% ethanol 23.3 Example  8 70% ethanol 24.2 Example 9 80% ethanol 23.3 Example 10 90% ethanol 22.5 Example 11 100% ethanol 23.4 Example 12 Methanol 23.3 Example 13 n-propanol 21.5 Example 14 Isopropanol 14.6 Example 15 2-butanol 23.2 Example 16 Acetone 5.5 Example 17 chloroform 2.1 Example 18 Ethyl acetate 4.3 Example 19 Butyl acetate 2.6

Example 21 Preparation of Noni Extract Using Supercritical Fluid Extraction

Noni fruit was washed with purified water, dried and crushed, and then 100 grams of the sample was placed in a supercritical fluid extractor (Jasco, Japan) and purified using a liquid chromatography pump (Supercritical fluid chromatograph, Jasco, Japan). Using carbon dioxide and cosolvents (such as a mixture of alcoholic spirits and non-polar solvents squalene in a 1: 1 ratio) up to 40 minutes every 4 minutes while flowing into a supercritical state at a temperature of 80 ° C and a pressure of 300 atm. The extract was received in a 10 ml glass test tube.

Experimental Example 1: Protein Synthesis Promoting Effect of Noni (Morinda citrifolia) Extract

Human normal fibroblasts (Korean Cell Line Bank) were seeded to 1 × 10 ⁶ cells in each well of a 48-well microplate and incubated for 24 hours at 37 ° C. in DMEM medium. Then, after discarding the medium, the medium prepared by mixing the Noni extract obtained in Example 8 in serum-free DMEM medium so that the final concentration is as shown in Table 2 (serum group) and serum-free DMEM medium containing noni extract (Control) and incubated further for 24 hours. After incubation, the supernatant of each well was collected and the amount of newly synthesized protein was measured using a protein analysis kit (Proteinassay kit, Bioland, USA), and then the amount of protein production compared to the control group was calculated. The results are shown in Table 2 below.

Concentration (µg / ml) Protein production (% of control) Control 100.0 10 110.4 50 120.4 200 134.1 500 165.1 1000 167.0

As shown in the results of Table 2, in the experimental group to which the noni extract was added, the amount of protein produced was much higher than that of the control group to which the noni extract was not added. Therefore, it can be seen that the Noni extract promotes the protein synthesis of fibroblasts.

Experimental Example 2: Collagen Synthesis Effect

Human normal fibroblasts were seeded to 1 × 10 ⁶ cells in each well of a 48-well microplate and incubated for 24 hours at 37 ° C. in DMEM medium. Subsequently, the experimental group in which the final concentration of the Noni extract extracted in Example 8 was replaced with serum-free DMEM medium and the control group in which the sample was not treated with serum-free DMEM medium was further incubated for 24 hours. After incubation, the supernatant of each well was collected and the amount of newly synthesized collagen was measured by measuring the amount of procollagen (procollagen) type I C-peptide (PICP) using a kit (Takara, Japan). The amount of PICP was converted to ng / ml, and the results are shown in Table 3 below by calculating the increase amount compared to the control group.

Treatment concentration Relative amount of type I collagen (%) relative to the control No treatment (control) 100.0 10 ng / ml TGF-β1 255.1 10 μg / ml 115.0 50 μg / ml 145.4 200 μg / ml 263.7 500 μg / ml 249.5 1000 μg / ml 222.1

As shown in Table 3, in the experimental group to which the noni extract was added, the amount of collagen produced was much higher than that of the control group, and in many cases, more than two times. Therefore, it can be seen that the Noni extract promotes collagen synthesis of fibroblasts.

Experimental Example 3: Integrin β1 expression enhancing effect

Human normal fibroblasts were seeded to 1 × 10 ⁶ cells in each well of a 48-well microplate and incubated for 24 hours at 37 ° C. in DMEM medium. Subsequently, a serum-free DMEM medium (experimental group) and a serum-free DMEM medium (control group) containing noni extract were prepared so that the final concentration of the Noni extract of Example 8 was 5, 10, 20, 50, and 100 ppm, respectively. And further incubated for 24 hours. After incubation, the expression level of integrin β1 was measured according to the EIA (Enzyme immnoassay) method (MK008 kit, Takara, Japan). In detail, cells were harvested by centrifugation, cell extracts were prepared, and the cell extracts were treated in wells coated with anti-integrin β1 antibody. Secondary antibodies were added and reacted at 4 ° C. for 45 minutes and then detected by OPD (ο-Phenylenediamine-HCl). After the stained OPD was dissolved in the OPD solution, the absorbance was measured at 530 nm with an ELISA reader, and the results are shown in Table 4.

Concentration (ng / ml) OD ₅₃₀ 0 0.504 0.5 0.531 One 0.589 2 0.563 5 0.787 10 0.987

From the results of Table 4, it can be seen that the noni extract promotes the synthesis of integrin β1 that plays an important role in the adhesion of cells in a concentration-dependent manner.

Prescription Example and Comparative Prescription Example

Through the experimental example it was confirmed that the Noni extract of the present invention is excellent in protein synthesis effect, collagen synthesis enhancement effect, integrin β1 expression enhancement effect. Thus, to prepare a cosmetic containing the noni extract of the present invention as an active ingredient to see if the effect is also applied to the actual skin as shown in the composition ratio of Table 5, the noni extract prepared in Example 8 to the flexible cosmetic composition Formulations containing 5.0 wt% and Comparative formulations containing no Noni extract were prepared:

ingredient Prescription Example Comparative Prescription Content (% by weight) Content (% by weight) Noni Extract (Example 8) 5.0 - glycerin 5.1 5.1 Propylene glycol 4.2 4.2 Tocopheryl Acetate 3.0 3.0 Liquid paraffin 4.6 4.6 Triethanolamine 1.0 1.0 Squalane 3.1 3.1 Macadamia Nut Oil 2.5 2.5 Polysorbate 60 1.6 1.6 Sorbitan sesquirrolate 1.6 1.6 Propylparaben 0.6 0.6 Carboxyl Vinyl Polymer 1.5 1.5 incense a very small amount a very small amount antiseptic a very small amount a very small amount Purified water Remaining amount Remaining amount system 100 100

Experimental Example 4: Evaluation of the wrinkle improvement effect of the cosmetic containing Noni extract-clinical trial

The wrinkle improvement effect of the cosmetic of this invention containing a noni extract was evaluated through the actual use test. The cream of the prescription example containing 5% of the Noni extract and the cream of the Comparative Example in which Noni extract was replaced with purified water were used (see Table 5). Twenty 30-40 year old women were randomly divided into two groups, and the creams of the prescription and the comparative example were washed twice every morning, and then the appropriate amount of the cream was corrected continuously for 2 months around the eyes. The wrinkle improvement effect of each subject was evaluated through visual observation and the results are shown in Table 6 below.

Wrinkle improvement effect (visual evaluation) Test Sample Excellent wrinkle improvement Wrinkle improvement effect slightly No wrinkle improvement Effectiveness% Prescription Example 8 8 4 70.0 Comparative Prescription One 3 16 45.0

Through the experimental results of Table 6, it can be seen that the cosmetic formulation of the formulation containing Noni extract showed a higher wrinkle improvement effect than the comparative example. In addition, skin irritation could not be observed in the subjects who applied the prescription of the present invention to the skin.

Experimental Example 5: skin elasticity improving effect-clinical trial

In the constant temperature and humidity room of 22 ° C and relative humidity of 45%, the creams of the above-described formulations and the comparative examples were applied to the eyes of 30 healthy women (average age 33.7 years) for a certain amount (0.03 g / 16 cm 2) for 12 weeks. Then, skin elasticity of each group was measured using a skin elasticity measuring instrument (Cutometer SEM 575, C + K Electronic Co., Germany). The results are shown in Table 7 below.

Skin elasticity improvement degree (%) Prescription Example Comparative example 33.6 15.8

Through the results of Table 7, the improvement of skin elasticity of the prescription example containing the Noni extract of the present invention, it was confirmed that the skin elasticity improvement is much higher than the cream of the comparative example does not contain the Noni extract.

Experimental Example 6: skin irritation test

The skin irritation of the cosmetic containing the noni extract of this invention was evaluated. Experiment using the cream of the prescription example and the cream of a comparative example containing a noni extract.

To test the skin irritation of the cosmetics, a patch test was conducted using a Haye's Test Chamber in 20 healthy adult men and women. Wipe the test site with 70% ethanol and dry it, and place a chamber (Finn chamber, 100 × 10, EPITEST, Finland) in which 15 μg or 15 μl of the prepared test substance is added to the inside of the forearm of the test subject. It was. The patch was applied for 24 hours, the patch was removed, and the test site was marked with a marker pen. 1 hour and 24 hours after each removal (1 hour after removal, 24 hours = 24 hours, 48 hours including patch attachment) using magnifier (8MC-150, DAZOR, USA) Was observed. Skin response was determined according to the regulations of the International Contact Dermatitis Research Group (ICDRG) (Table 8), and the average skin reactivity was calculated by the following equation and the results are shown in Table 9.

Evaluation criteria and score of skin reaction sign score Evaluation standard - 0 No response, normal skin ± 0.5 Faint or light erythema + 1.0 Boundary but weak erythema, edema and papules ++ 2.0 Pronounced erythema, papules and vesicles +++ 3.0 Severe erythema and vesicle formation ++++ 6.0 Cannon formation

Test substance 24 hours 48 hours Average skin reactivity (n = 20) ± + ++ ± + ++ Prescription Example One - - One - - 0.42 Comparative example One - - One - - 0.42

As shown in Table 9, the skin reactivity of the cream of the comparative example containing no noni extract of the present invention was very low, it can be seen that the other components of the cream does not cause skin irritation. In addition, no skin irritation was observed even in the cream of the formulation to which the noni extract of the present invention was added, and it was found that the skin irritation was not caused by the noni extract.

Experimental Example  7: stability test of the formulation

Formulation stability experiments were carried out using the cream of the formulation example containing the noni extract of the present invention and the comparative example containing no noni extract.

Evaluation criteria for long-term preservation stability of the cosmetics in units of 1 week, 1 month and 6 months in a thermostat and room temperature of 4 ℃, 45 ℃, 50 ℃ and 4 ℃-45 ℃ cycle (Cycle) Was evaluated, and the results are shown in Table 11.

Good O Instability X detach △

Temperature term Prescription Example Comparative example 4 ℃ 1 week 0 0 1 month 0 0 6 months 0 0 45 ℃ 1 week 0 0 1 month 0 0 6 months 0 0 50 ℃ 1 week 0 0 1 month 0 0 6 months 0 0 Cycle 1 week 0 0 1 month 0 0 6 months 0 0 Room temperature 1 week 0 0 1 month 0 0 6 months 0 0

As shown in Table 11, when the cream of the comparative example does not contain the noni extract of the active ingredient was found to have good stability, it can be seen that there is no problem in stability by the other ingredients of the cosmetics, containing the noni extract Long-term storage stability also appeared in the cosmetic formulation of the formulation example, it was found that there is no problem in stability even by the addition of the active ingredient Noni extract.

As described in detail above, the present invention provides a cosmetic composition for preventing skin aging containing noni extract as an active ingredient. The cosmetic of the present invention improves the biosynthesis of collagen constituting the matrix of the dermis of the skin and improves skin wrinkles by containing a noni extract having an effective effect of enhancing the expression of integrin involved in the dermal matrix and the interaction between cells. And excellent skin elasticity improvement effect is effective in preventing skin aging. In addition, the cosmetic of the present invention does not cause skin irritation and excellent stability of the formulation.

Having described the specific part of the present invention in detail, it is apparent to those skilled in the art that the specific technology is merely a preferred embodiment, and the scope of the present invention is not limited thereto. Thus, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.

Claims (6)

delete Skin elasticity containing Morinda citrifolia extract as an active ingredient extracted using a solvent selected from the group consisting of methanol, anhydrous or hydrous lower alcohol having 3-4 carbon atoms, acetone, ethyl acetate, chloroform and 70% ethyl alcohol Improvement cosmetic composition. The cosmetic composition according to claim 2, wherein the noni extract is extracted from the fruit of noni. The cosmetic composition according to claim 2, wherein the noni extract is contained in an amount of 0.000001-15.0% by weight based on the total weight of the cosmetic composition. delete 3. The group of claim 2 wherein the cosmetic composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Cosmetic composition, characterized in that it has a formulation selected from.