JPWO2020158958A5 - - Google Patents
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- Publication number
- JPWO2020158958A5 JPWO2020158958A5 JP2021568451A JP2021568451A JPWO2020158958A5 JP WO2020158958 A5 JPWO2020158958 A5 JP WO2020158958A5 JP 2021568451 A JP2021568451 A JP 2021568451A JP 2021568451 A JP2021568451 A JP 2021568451A JP WO2020158958 A5 JPWO2020158958 A5 JP WO2020158958A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyrrolidin
- difluoro
- biphenyl
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Claims (9)
- N'-{(2S,3R,4S)-1-(アゼチジン-1-カルボニル)-4-フルオロ-2-[(2-フルオロ-3'-メチル[1,1'-ビフェニル]-3-イル)メチル]ピロリジン-3-イル}-N,N-ジメチル硫酸 ジアミドまたはその塩。
- N-[(2S,3R)-2-[(2,3'-ジフルオロ[1,1'-ビフェニル]-3-イル)メチル]-4,4-ジフルオロ-1-(2-メチルプロパノイル)ピロリジン-3-イル]エタンスルホンアミドまたはその塩。
- N-{(2S,3R)-4,4-ジフルオロ-1-(2-ヒドロキシ-2-メチルプロパノイル)-2-[(2,3',5'-トリフルオロ[1,1'-ビフェニル]-3-イル)メチル]ピロリジン-3-イル}エタンスルホンアミドまたはその塩。
- N-{(2S,3R)-4,4-ジフルオロ-1-(2-ヒドロキシ-2-メチルプロパノイル)-2-[(2,3',5'-トリフルオロ[1,1'-ビフェニル]-3-イル)メチル]ピロリジン-3-イル}メタンスルホンアミドまたはその塩。
- N-{(2S,3R)-1-(ビシクロ[1.1.1]ペンタン-1-カルボニル)-4,4-ジフルオロ-2-[(2,3',5'-トリフルオロ[1,1'-ビフェニル]-3-イル)メチル]ピロリジン-3-イル}メタンスルホンアミドまたはその塩。
- N-{(2S,3R)-1-(シクロプロパンカルボニル)-4,4-ジフルオロ-2-[(2,3',5'-トリフルオロ[1,1'-ビフェニル]-3-イル)メチル]ピロリジン-3-イル}エタンスルホンアミドまたはその塩。
- N-{(2S,3R)-4,4-ジフルオロ-1-((1s,3R)-3-フルオロシクロブタン-1-カルボニル)-2-[(2,3',5'-トリフルオロ[1,1'-ビフェニル]-3-イル)メチル]ピロリジン-3-イル}エタンスルホンアミドまたはその塩。
- N-{(2S,3R)-4,4-ジフルオロ-1-((1s,3R)-3-フルオロシクロブタン-1-カルボニル)-2-[(2,3',5'-トリフルオロ[1,1'-ビフェニル]-3-イル)メチル]ピロリジン-3-イル}メタンスルホンアミドまたはその塩。
- N'-{(2S,3R)-1-(アゼチジン-1-カルボニル)-4,4-ジフルオロ-2-[(2-フルオロ-3'-メチル[1,1'-ビフェニル]-3-イル)メチル]ピロリジン-3-イル}-N,N-ジメチル硫酸 ジアミドまたはその塩。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023050325A JP7502512B2 (ja) | 2019-01-31 | 2023-03-27 | 複素環化合物およびその用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019015488 | 2019-01-31 | ||
| JP2019015488 | 2019-01-31 | ||
| PCT/JP2020/004444 WO2020158958A1 (en) | 2019-01-31 | 2020-01-30 | Heterocyclic compound and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023050325A Division JP7502512B2 (ja) | 2019-01-31 | 2023-03-27 | 複素環化合物およびその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022519331A JP2022519331A (ja) | 2022-03-22 |
| JPWO2020158958A5 true JPWO2020158958A5 (ja) | 2023-02-03 |
| JP7253640B2 JP7253640B2 (ja) | 2023-04-06 |
Family
ID=69770989
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021568451A Active JP7253640B2 (ja) | 2019-01-31 | 2020-01-30 | 複素環化合物およびその用途 |
| JP2023050325A Active JP7502512B2 (ja) | 2019-01-31 | 2023-03-27 | 複素環化合物およびその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023050325A Active JP7502512B2 (ja) | 2019-01-31 | 2023-03-27 | 複素環化合物およびその用途 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20230040770A1 (ja) |
| EP (1) | EP3917616A1 (ja) |
| JP (2) | JP7253640B2 (ja) |
| KR (1) | KR20210121080A (ja) |
| CN (6) | CN118290408A (ja) |
| AR (1) | AR117916A1 (ja) |
| AU (1) | AU2020215380A1 (ja) |
| BR (1) | BR112021014180A2 (ja) |
| CA (1) | CA3124536A1 (ja) |
| CL (1) | CL2021001973A1 (ja) |
| CO (1) | CO2021011188A2 (ja) |
| EA (1) | EA202192138A1 (ja) |
| EC (1) | ECSP21056325A (ja) |
| IL (1) | IL284073A (ja) |
| MX (1) | MX2021008241A (ja) |
| PE (1) | PE20211700A1 (ja) |
| SG (1) | SG11202106791XA (ja) |
| TW (1) | TWI832962B (ja) |
| WO (1) | WO2020158958A1 (ja) |
| ZA (1) | ZA202106304B (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4065585A1 (en) | 2019-11-25 | 2022-10-05 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| CN115003670A (zh) | 2019-11-27 | 2022-09-02 | 武田药品工业株式会社 | 杂环化合物 |
| EP4200295A1 (en) | 2020-08-18 | 2023-06-28 | Merck Sharp & Dohme LLC | Bicycloheptane pyrrolidine orexin receptor agonists |
| WO2022051583A1 (en) * | 2020-09-03 | 2022-03-10 | Orexia Therapeutics Limited | Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and their uses as orexin-2 receptor agonists |
| JP2023540344A (ja) * | 2020-09-03 | 2023-09-22 | センテッサ ファーマシューティカルズ （オレキシア） リミテッド | 二環式複素環誘導体およびオレキシン－２受容体アゴニストとしてのそれらの使用 |
| AU2021368052A1 (en) * | 2020-11-02 | 2023-06-08 | Merck Sharp & Dohme Llc | Macrocyclic urea orexin receptor agonists |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| WO2022208478A1 (en) | 2021-04-02 | 2022-10-06 | Takeda Pharmaceutical Company Limited | Use of an orexin 2 receptor agonist for post operation recovery |
| WO2022207935A1 (en) * | 2021-04-02 | 2022-10-06 | Orexia Therapeutics Limited | 2-(3-ethynylbenzyl)-substituted heterocycle derivatives as orexin-2 agonists |
| TW202400606A (zh) | 2022-03-01 | 2024-01-01 | 英商歐瑞夏治療公司 | 中環或大環之經苄基取代之雜環衍生物及相關用途 |
| WO2023199091A1 (en) | 2022-04-12 | 2023-10-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US11987586B1 (en) | 2022-10-31 | 2024-05-21 | Takeda Pharmaceutical Company Limited | Pyrrolo[1,2-c]imidazole derivatives as orexin type 2 receptor agonists |
| WO2024095158A1 (en) | 2022-10-31 | 2024-05-10 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
| WO2024116086A1 (en) | 2022-11-30 | 2024-06-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| WO2024128305A1 (ja) * | 2022-12-16 | 2024-06-20 | 第一三共株式会社 | ２－アザビシクロ［３．１．１］ヘプタン化合物 |
| US20240309016A1 (en) | 2023-03-16 | 2024-09-19 | Takeda Pharmaceutical Company Limited | Macrocyclic heterocycle compounds and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
| JP4484410B2 (ja) | 1999-06-28 | 2010-06-16 | オクラホマ メディカル リサーチ ファウンデーション | メマプシン２のインヒビターおよびその使用 |
| AU6615300A (en) | 1999-07-30 | 2001-02-19 | Board Of Trustees Of The Leland Stanford Junior University | Hypocretin and hypocretin receptors in regulation of sleep and related disorders |
| US7112566B1 (en) | 1999-09-17 | 2006-09-26 | The Regents Of The University Of California | Systemic administration of Hypocretin-1 |
| US6204245B1 (en) | 1999-09-17 | 2001-03-20 | The Regents Of The University Of California | Treatment of narcolepsy with immunosuppressants |
| WO2001074162A1 (en) | 2000-04-04 | 2001-10-11 | The Regents Of The University Of California | Treatment of sleep disorders with hypocretin-1 |
| CA2498264A1 (en) | 2002-09-09 | 2004-05-13 | Nura, Inc. | G protein coupled receptors and uses thereof |
| US20080260744A1 (en) | 2002-09-09 | 2008-10-23 | Omeros Corporation | G protein coupled receptors and uses thereof |
| ATE391727T1 (de) | 2002-12-13 | 2008-04-15 | Janssen Pharmaceutica Nv | Verfahren zur identifikation von modulatoren des humanen orexin-2-rezeptors |
| HUP0304101A3 (en) * | 2003-12-22 | 2008-10-28 | Sanofi Aventis | Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
| US8383641B2 (en) | 2006-04-14 | 2013-02-26 | Abbott Gmbh & Co. Kg | Aryloxyethylamine compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
| AU2012200270A1 (en) * | 2007-05-23 | 2012-02-09 | Merck Sharp & Dohme Corp. | Pyridyl piperidine orexin receptor antagonists |
| WO2009049215A1 (en) | 2007-10-10 | 2009-04-16 | Wake Forest University Health Sciences | Methods to reduce the effects of sleep deprivation |
| US8258163B2 (en) | 2008-06-04 | 2012-09-04 | Board Of Regents, The University Of Texas System | Small-molecule agonists for type-2 orexin receptor |
| EP2694472B1 (en) | 2011-04-05 | 2020-03-11 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| TW201341380A (zh) * | 2012-04-05 | 2013-10-16 | Takeda Pharmaceutical | 磺醯胺衍生物及其用途 |
| AR092955A1 (es) | 2012-10-10 | 2015-05-06 | Actelion Pharmaceuticals Ltd | Antagonistas de receptores de orexina los cuales son derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)-pirrolidin-1-il]-metanona |
| WO2014170343A1 (en) | 2013-04-15 | 2014-10-23 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Depolarizing agents and nicotinic acetylcholine receptor modulators for treating dopaminergic-related disorders |
| WO2014198880A1 (en) | 2013-06-14 | 2014-12-18 | Ferrer Internacional, S.A. | 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity |
| WO2015048091A1 (en) | 2013-09-24 | 2015-04-02 | The Board Of Regents Of The University Of Texas System | Orexin-control of bone formation and loss |
| US10172916B2 (en) | 2013-11-15 | 2019-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating heart failure with agonists of hypocretin receptor 2 |
| SG11201604639YA (en) | 2013-12-12 | 2016-07-28 | Univ Tsukuba | Sulfonamide derivative or pharmaceutically acceptable acid addition salt thereof |
| WO2015147240A1 (ja) | 2014-03-28 | 2015-10-01 | 国立大学法人筑波大学 | 敗血症の予防治療剤 |
| US10221170B2 (en) | 2014-08-13 | 2019-03-05 | Eolas Therapeutics, Inc. | Difluoropyrrolidines as orexin receptor modulators |
| EP3029024A1 (en) | 2014-12-02 | 2016-06-08 | Ferrer Internacional, S.A. | 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity |
| JP6746107B2 (ja) | 2015-02-19 | 2020-08-26 | 国立大学法人 筑波大学 | スルホンアミド誘導体またはその薬学的に許容される酸付加塩 |
| JP6775803B2 (ja) | 2015-06-12 | 2020-10-28 | 国立大学法人 筑波大学 | スルホンアミド誘導体またはその薬学的に許容される酸付加塩 |
| WO2017044889A1 (en) | 2015-09-10 | 2017-03-16 | The Regents Of The University Of California | Lrh-1 modulators |
| AU2017215021B2 (en) * | 2016-02-04 | 2020-07-23 | Takeda Pharmaceutical Company Limited | Substituted piperidine compound and use thereof |
| JP6957598B2 (ja) | 2017-03-08 | 2021-11-02 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
| WO2018164192A1 (ja) | 2017-03-08 | 2018-09-13 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
| EP3663281B1 (en) | 2017-08-03 | 2022-12-28 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and application thereof |
| SG11202000831XA (en) | 2017-08-03 | 2020-02-27 | Takeda Pharmaceuticals Co | Heterocyclic compound and use thereof |
| JPWO2019112007A1 (ja) | 2017-12-07 | 2020-12-24 | 国立大学法人 筑波大学 | 鎮痛薬による眠気の予防または治療薬 |
| EP3816153B1 (en) | 2018-06-29 | 2023-10-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| WO2020004536A1 (ja) | 2018-06-29 | 2020-01-02 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| US12071434B2 (en) | 2018-12-12 | 2024-08-27 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3896060B1 (en) | 2018-12-12 | 2023-08-16 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US20220144771A1 (en) | 2019-02-13 | 2022-05-12 | Merck Sharp & Dohme Corp. | Pyrrolidine orexin receptor agonists |
| US11098029B2 (en) | 2019-02-13 | 2021-08-24 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
-
2020
- 2020-01-30 US US17/427,490 patent/US20230040770A1/en not_active Abandoned
- 2020-01-30 MX MX2021008241A patent/MX2021008241A/es unknown
- 2020-01-30 JP JP2021568451A patent/JP7253640B2/ja active Active
- 2020-01-30 CN CN202410132356.4A patent/CN118290408A/zh active Pending
- 2020-01-30 CN CN202410125823.0A patent/CN118344346A/zh active Pending
- 2020-01-30 EP EP20709748.6A patent/EP3917616A1/en active Pending
- 2020-01-30 AR ARP200100236A patent/AR117916A1/es unknown
- 2020-01-30 BR BR112021014180-4A patent/BR112021014180A2/pt unknown
- 2020-01-30 CN CN202080011417.1A patent/CN113395993B/zh active Active
- 2020-01-30 CN CN202410118961.6A patent/CN118271297A/zh active Pending
- 2020-01-30 TW TW109102825A patent/TWI832962B/zh active
- 2020-01-30 EA EA202192138A patent/EA202192138A1/ru unknown
- 2020-01-30 CA CA3124536A patent/CA3124536A1/en active Pending
- 2020-01-30 PE PE2021001139A patent/PE20211700A1/es unknown
- 2020-01-30 KR KR1020217024931A patent/KR20210121080A/ko unknown
- 2020-01-30 SG SG11202106791XA patent/SG11202106791XA/en unknown
- 2020-01-30 CN CN202410149044.4A patent/CN118271298A/zh active Pending
- 2020-01-30 AU AU2020215380A patent/AU2020215380A1/en active Pending
- 2020-01-30 US US16/777,273 patent/US11028048B2/en active Active
- 2020-01-30 CN CN202410143991.2A patent/CN118420600A/zh active Pending
- 2020-01-30 WO PCT/JP2020/004444 patent/WO2020158958A1/en active Application Filing
-
2021
- 2021-04-23 US US17/239,191 patent/US20210276949A1/en not_active Abandoned
- 2021-06-16 IL IL284073A patent/IL284073A/en unknown
- 2021-07-27 CL CL2021001973A patent/CL2021001973A1/es unknown
- 2021-07-30 EC ECSENADI202156325A patent/ECSP21056325A/es unknown
- 2021-08-25 CO CONC2021/0011188A patent/CO2021011188A2/es unknown
- 2021-08-30 ZA ZA2021/06304A patent/ZA202106304B/en unknown
-
2023
- 2023-03-27 JP JP2023050325A patent/JP7502512B2/ja active Active
- 2023-11-27 US US18/520,037 patent/US20240360080A1/en active Pending
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