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JPWO2020047473A5
JPWO2020047473A5 JP2021536663A JP2021536663A JPWO2020047473A5 JP WO2020047473 A5 JPWO2020047473 A5 JP WO2020047473A5 JP 2021536663 A JP2021536663 A JP 2021536663A JP 2021536663 A JP2021536663 A JP 2021536663A JP WO2020047473 A5 JPWO2020047473 A5 JP WO2020047473A5
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JP2021534835A (ja
JP7474769B2 (ja
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JP2021536663A 2018-08-30 2019-08-30 一本鎖および多鎖キメラポリペプチドならびにその使用方法 Active JP7474769B2 (ja)

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JP2024065081A JP2024096876A (ja) 2018-08-30 2024-04-15 一本鎖および多鎖キメラポリペプチドならびにその使用方法

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US201862725010P 2018-08-30 2018-08-30
US201862725038P 2018-08-30 2018-08-30
US201862724969P 2018-08-30 2018-08-30
US201862725043P 2018-08-30 2018-08-30
US62/725,043 2018-08-30
US62/724,969 2018-08-30
US62/725,010 2018-08-30
US62/725,038 2018-08-30
US201862746832P 2018-10-17 2018-10-17
US62/746,832 2018-10-17
US201862749007P 2018-10-22 2018-10-22
US62/749,007 2018-10-22
US201862749506P 2018-10-23 2018-10-23
US62/749,506 2018-10-23
US201962816683P 2019-03-11 2019-03-11
US62/816,683 2019-03-11
US201962817230P 2019-03-12 2019-03-12
US201962817241P 2019-03-12 2019-03-12
US201962817244P 2019-03-12 2019-03-12
US62/817,244 2019-03-12
US62/817,230 2019-03-12
US62/817,241 2019-03-12
US201962881039P 2019-07-31 2019-07-31
US201962881088P 2019-07-31 2019-07-31
US62/881,088 2019-07-31
US62/881,039 2019-07-31
PCT/US2019/049158 WO2020047473A1 (en) 2018-08-30 2019-08-30 Single-chain and multi-chain chimeric polypeptides and uses thereof

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JP2021534835A JP2021534835A (ja) 2021-12-16
JPWO2020047473A5 true JPWO2020047473A5 (ru) 2022-08-26
JP7474769B2 JP7474769B2 (ja) 2024-04-25

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JP2021536663A Active JP7474769B2 (ja) 2018-08-30 2019-08-30 一本鎖および多鎖キメラポリペプチドならびにその使用方法
JP2021536660A Active JP7449292B2 (ja) 2018-08-30 2019-08-30 加齢関連障害の治療法
JP2024031433A Pending JP2024063153A (ja) 2018-08-30 2024-03-01 加齢関連障害の治療法
JP2024065081A Pending JP2024096876A (ja) 2018-08-30 2024-04-15 一本鎖および多鎖キメラポリペプチドならびにその使用方法

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JP2021536660A Active JP7449292B2 (ja) 2018-08-30 2019-08-30 加齢関連障害の治療法
JP2024031433A Pending JP2024063153A (ja) 2018-08-30 2024-03-01 加齢関連障害の治療法
JP2024065081A Pending JP2024096876A (ja) 2018-08-30 2024-04-15 一本鎖および多鎖キメラポリペプチドならびにその使用方法

Country Status (8)

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US (4) US11730762B2 (ru)
EP (2) EP3844182A1 (ru)
JP (4) JP7474769B2 (ru)
CN (2) CN112888445A (ru)
AU (2) AU2019328575B2 (ru)
CA (2) CA3109361A1 (ru)
IL (2) IL280920A (ru)
WO (2) WO2020047473A1 (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3648786A4 (en) 2017-07-03 2021-12-15 Torque Therapeutics, Inc. FUSION MOLECULES TARGETING IMMUNE REGULATORY CELLS AND THEIR USES
EP3844181A1 (en) 2018-08-30 2021-07-07 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
CA3108951A1 (en) 2018-08-30 2020-03-05 HCW Biologics, Inc. Single-chain chimeric polypeptides and uses thereof
AU2019328575B2 (en) 2018-08-30 2024-07-11 Immunitybio, Inc. Single-chain and multi-chain chimeric polypeptides and uses thereof
CA3143035A1 (en) 2019-06-21 2020-12-24 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
CN115380045A (zh) * 2020-02-11 2022-11-22 Hcw生物科技公司 激活调节性t细胞的方法
AU2021220870A1 (en) 2020-02-11 2022-08-04 Immunitybio, Inc. Methods of treating age-related and inflammatory diseases
AU2021219720A1 (en) * 2020-02-11 2022-08-04 Immunitybio, Inc. Chromatography resin and uses thereof
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
EP4157460A1 (en) * 2020-06-01 2023-04-05 HCW Biologics, Inc. Methods of treating aging-related disorders
WO2021247003A1 (en) * 2020-06-01 2021-12-09 HCW Biologics, Inc. Methods of treating aging-related disorders
WO2022086988A1 (en) * 2020-10-20 2022-04-28 Cura Therapeutics, Inc. Multi-functional and multi-valent interleukin-tgf-beta receptor fusion polypeptides
AU2021367306A1 (en) 2020-10-20 2023-06-01 Cura Therapeutics, Inc. Multi-functional and multi-valent interleukin-tgf-beta receptor fusion polypeptides
CN114569708B (zh) * 2020-12-02 2023-07-04 四川大学华西医院 Nkg2d car-免疫细胞在抗衰老中应用
EP4294422A1 (en) 2021-02-17 2023-12-27 Cura Therapeutics, Inc. Anti-pathogen interleukin-tgf-beta receptor fusion polypeptides
CN117222414A (zh) 2021-03-01 2023-12-12 脱落性治疗公司 用于激活恒定自然杀伤t-细胞的化合物和用于消除炎性衰老细胞的方法
CN115477705B (zh) * 2021-06-16 2024-02-23 四川大学华西医院 一种基于颗粒酶b构建的嵌合抗原受体免疫细胞制备及其应用
WO2023081887A1 (en) * 2021-11-08 2023-05-11 Albert Einstein College Of Medicine Methods, compositions, and kits for modifying immune cell activity via kir2dl5
WO2023090901A1 (ko) * 2021-11-18 2023-05-25 의료법인 성광의료재단 기계 학습을 이용한 세포 노화의 마커를 선별하는 방법, 세포 노화 바이오 마커, 및 이를 이용한 세놀리틱 제제를 스크리닝 하는 방법
CN114349869B (zh) * 2021-12-20 2023-09-26 上海恩凯细胞技术有限公司 一种双特异性的nk细胞激动剂及制备方法和应用
WO2023133357A2 (en) * 2022-01-10 2023-07-13 Expression Therapeutics, Llc Engineered t cells
US20240075141A1 (en) 2022-03-18 2024-03-07 WUGEN, Inc. Chimeric receptor constructs for nk cells
WO2023183853A1 (en) 2022-03-22 2023-09-28 WUGEN, Inc. Hybrid promoters, vectors containing same and methods of use
WO2023201221A1 (en) * 2022-04-11 2023-10-19 Duke University Recombinant tim-4 protein, chimeric antigen receptor (car) t cell delivery system and methods of making and using same
WO2024112866A1 (en) * 2022-11-22 2024-05-30 Expression Therapeutics, Llc Engineered t cells
CN116271008A (zh) * 2022-12-30 2023-06-23 广东天普生化医药股份有限公司 含有安柯瑞和卡瑞利珠单抗的药物组合物及其应用
WO2024151784A1 (en) * 2023-01-10 2024-07-18 Expression Therapeutics, Llc Engineered t cells

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749853B1 (en) 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
GB9324807D0 (en) 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
ATE198712T1 (de) * 1994-07-11 2001-02-15 Univ Texas Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen
US6117980A (en) 1997-02-21 2000-09-12 Genentech, Inc. Humanized anti-IL-8 monoclonal antibodies
US20060235209A9 (en) 1997-03-10 2006-10-19 Jin-An Jiao Use of anti-tissue factor antibodies for treating thromboses
US20030109680A1 (en) 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
JP2001206899A (ja) 1999-11-18 2001-07-31 Japan Tobacco Inc TGF−βII型受容体に対するヒトモノクローナル抗体及びその医薬用途
IL142515A0 (en) 1999-12-20 2002-03-10 Merck & Co Inc Pharmaceutical kit
WO2001083755A2 (en) 2000-04-28 2001-11-08 La Jolla Institute For Allergy And Immunology Human anti-cd40 antibodies and methods of making and using same
DK1355919T3 (da) 2000-12-12 2011-03-14 Medimmune Llc Molekyler med længere halveringstider, sammensætninger og anvendelser deraf
EP1345969B1 (fr) 2000-12-26 2010-08-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anticorps anti-cd28
US20040204481A1 (en) * 2001-04-12 2004-10-14 Pnina Fishman Activation of natural killer cells by adenosine A3 receptor agonists
TWI338009B (en) 2001-10-29 2011-03-01 Genentech Inc Antibodies for inhibiting blood coagulation and methods of use thereof
AU2003239197A1 (en) 2002-06-07 2003-12-22 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Novel stable anti-cd22 antibodies
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
EP1536012A4 (en) 2002-08-30 2006-03-08 Chemo Sero Therapeut Res Inst HUMAN-TYPE ANTIHUMAN INTERLEUKIN-6 ANTIBODY ANTIBODY ANTIBODY FRAGMENT
ES2559763T3 (es) 2002-09-10 2016-02-15 Affimed Gmbh Anticuerpo humano específico de CD3 con propiedades inmunosupresoras
AU2003288675B2 (en) 2002-12-23 2010-07-22 Medimmune Limited Antibodies against PD-1 and uses therefor
CA2516832A1 (en) 2003-02-27 2004-09-10 Theravision Gmbh A molecule which binds cd80 and cd86
JP2006523682A (ja) 2003-03-21 2006-10-19 ワイス インターロイキン−21/インターロイキン−21受容体のアゴニストを用いた免疫学的障害の治療
RU2369636C2 (ru) * 2003-05-23 2009-10-10 Уайт Лиганд gitr и связанные с лигандом gitr молекулы и антитела и варианты их применения
US9005613B2 (en) 2003-06-16 2015-04-14 Immunomedics, Inc. Anti-mucin antibodies for early detection and treatment of pancreatic cancer
JP2005124568A (ja) * 2003-10-01 2005-05-19 Junichi Masuyama 細胞活性化方法及びこれを用いる細胞製造方法並びに医薬組成物
NZ549040A (en) 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
US8133485B2 (en) 2004-03-30 2012-03-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Bi-specific complexes for targeting cells involved in allergic-type reactions, compositions and uses thereof
US7393833B2 (en) 2005-03-09 2008-07-01 The Board Of Regents Of The University Of Oklahoma Chimeric proteins with phosphatidylserine binding domains
AU2006224313B2 (en) * 2005-03-17 2011-08-11 Ucl Biomedica Plc Method for actvating Natural Killer cells by tumor cell preparation in vitro
JP5122441B2 (ja) 2005-04-19 2013-01-16 シアトル ジェネティックス, インコーポレイテッド ヒト化抗cd70結合剤およびその使用
EA012970B1 (ru) 2005-04-26 2010-02-26 Пфайзер Инк. Антитела против р-кадгерина
KR101281208B1 (ko) 2005-05-11 2013-07-26 필로겐 에스.피.에이. 피브로넥틴 ed-b에 대한 항체 l19 및 인터루킨12의 융합 단백질
GB0510790D0 (en) 2005-05-26 2005-06-29 Syngenta Crop Protection Ag Anti-CD16 binding molecules
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP1777294A1 (en) * 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
PL2274008T3 (pl) 2008-03-27 2014-07-31 Zymogenetics Inc Kompozycje i sposoby hamowania PDGFRbeta i VEGF-A
MX2011000011A (es) 2008-06-25 2011-09-27 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles que inhiben el vegf.
NZ603698A (en) 2008-07-08 2014-03-28 Abbvie Inc Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
WO2010017103A2 (en) 2008-08-04 2010-02-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Fully human anti-human nkg2d monoclonal antibodies
US8298533B2 (en) 2008-11-07 2012-10-30 Medimmune Limited Antibodies to IL-1R1
HUE034832T2 (hu) 2008-12-09 2021-12-28 Hoffmann La Roche Anti-PD-L1 antitestek és alkalmazásuk T-sejt-funkció fokozására
CA2772628A1 (en) 2009-09-01 2011-03-10 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
DE102009045006A1 (de) 2009-09-25 2011-04-14 Technische Universität Dresden Anti-CD33 Antikörper und ihre Anwendung zum Immunotargeting bei der Behandlung von CD33-assoziierten Erkrankungen
TW201119676A (en) 2009-10-15 2011-06-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
CA2789623A1 (en) 2010-02-11 2011-08-18 Alexion Pharmaceutical, Inc. Therapeutic methods using anti-cd200 antibodies
CA2795279C (en) 2010-04-08 2020-05-05 Jn Biosciences Llc Antibodies to cd122
TWI629483B (zh) 2010-06-11 2018-07-11 協和醱酵麒麟有限公司 anti-TIM-3 antibody
EP3252072A3 (en) 2010-08-03 2018-03-14 AbbVie Inc. Dual variable domain immunoglobulins and uses thereof
JP2012034668A (ja) 2010-08-12 2012-02-23 Tohoku Univ ヒト型化抗egfr抗体リジン置換可変領域断片及びその利用
JP6251570B2 (ja) 2010-09-21 2017-12-20 アルター・バイオサイエンス・コーポレーション 多量体il−15可溶性融合分子並びにその製造及び使用方法
CN102153653B (zh) 2010-12-30 2012-08-15 厦门大学 肿瘤血管靶向多肽与组织因子的融合蛋白及其制备方法
GB201103955D0 (en) 2011-03-09 2011-04-20 Antitope Ltd Antibodies
TWI631136B (zh) 2011-04-19 2018-08-01 莫瑞麥克製藥公司 單特異性及雙特異性抗igf-1r及抗erbb3抗體
RS57279B1 (sr) 2011-04-25 2018-08-31 Daiichi Sankyo Co Ltd Anti-b7-h3 antitelo
BR112013030017A2 (pt) 2011-05-25 2020-10-13 Innate Pharma Sa anticorpos anti-kir para o tratamento de distúrbios inflamatórios
US8753640B2 (en) 2011-05-31 2014-06-17 University Of Washington Through Its Center For Commercialization MIC-binding antibodies and methods of use thereof
US9403911B2 (en) 2011-06-06 2016-08-02 Board Of Regents Of The University Of Nebraska Compositions and methods for detection and treatment of cancer
ES2677367T3 (es) 2011-06-22 2018-08-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticuerpos anti-Axl y usos de los mismos
EP2537933A1 (en) 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
WO2013068946A2 (en) 2011-11-11 2013-05-16 Rinat Neuroscience Corp. Antibodies specific for trop-2 and their uses
KR101535341B1 (ko) 2012-07-02 2015-07-13 한화케미칼 주식회사 Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도
PE20150645A1 (es) 2012-08-08 2015-05-11 Roche Glycart Ag Proteinas de fusion de interleuquina 10 y usos de las mismas
US20150218280A1 (en) 2012-08-10 2015-08-06 University Of Southern California CD20 scFv-ELPs METHODS AND THERAPEUTICS
WO2014033130A1 (en) 2012-08-28 2014-03-06 Institut Curie Cluster of differentiation 36 (cd36) as a therapeutic target for hiv infection
CA2889962C (en) 2012-11-20 2023-10-24 Sanofi Anti-ceacam5 antibodies and uses thereof
ES2895848T3 (es) 2012-12-17 2022-02-22 Cell Medica Inc Anticuerpos contra IL-1 beta
EP2948475A2 (en) 2013-01-23 2015-12-02 AbbVie Inc. Methods and compositions for modulating an immune response
WO2014130635A1 (en) 2013-02-20 2014-08-28 Novartis Ag Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
US9790274B2 (en) 2013-03-14 2017-10-17 The Board Of Regents Of The University Of Texas System Monoclonal antibodies targeting EpCAM for detection of prostate cancer lymph node metastases
SG11201509609SA (en) 2013-05-24 2015-12-30 Univ Texas Chimeric antigen receptor-targeting monoclonal antibodies
JP2015030666A (ja) 2013-07-31 2015-02-16 学校法人順天堂 抗ヒトcd26モノクローナル抗体又はその抗原結合性断片
CN103709251B (zh) 2013-12-19 2016-04-13 江苏众红生物工程创药研究院有限公司 全人源抗cd26抗体及其应用
KR102127408B1 (ko) 2014-01-29 2020-06-29 삼성전자주식회사 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
FR3021970B1 (fr) 2014-06-06 2018-01-26 Universite Sciences Technologies Lille Anticorps dirige contre la galectine 9 et inhibiteur de l'activite suppressive des lymphocytes t regulateurs
TWI790593B (zh) 2014-08-19 2023-01-21 美商默沙東有限責任公司 抗tigit抗體
HUE047806T2 (hu) 2014-08-29 2020-05-28 Hoffmann La Roche Kombinációs kezelés tumort célzó IL-2-variáns immuncitokinekkel és humán PD-L1 elleni antitestekkel
ES2862701T3 (es) 2014-12-22 2021-10-07 Univ Rockefeller Anticuerpos agonistas anti-MERTK y usos de los mismos
WO2016154585A1 (en) 2015-03-26 2016-09-29 Charles Sentman Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using
JP2018512892A (ja) 2015-04-17 2018-05-24 エルサリー バイオテックElsalysbiotech 抗tyro3抗体及びその使用
KR101778439B1 (ko) * 2015-04-27 2017-09-14 울산대학교 산학협력단 자연살해세포 활성화제를 유효성분으로 함유하는 면역증강 및 항암활성증진용 조성물
TR201901445T4 (tr) 2015-08-06 2019-02-21 Agency Science Tech & Res Il2rbeta/yaygın gamma zinciri antikorları.
JP6931228B2 (ja) 2015-09-11 2021-09-01 ワイズ・エー・シー株式会社 抗cd26抗体と他の抗癌剤とを組み合わせた癌治療用組成物
CN113956358A (zh) 2015-09-25 2022-01-21 豪夫迈·罗氏有限公司 抗tigit抗体和使用方法
AU2016353231B2 (en) 2015-11-13 2020-08-13 Dana-Farber Cancer Institute, Inc. An NKG2D-Ig fusion protein for cancer immunotherapy
WO2017149538A1 (en) 2016-03-01 2017-09-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antibodies specific to human poliovirus receptor (pvr)
US11963980B2 (en) 2016-04-25 2024-04-23 Musc Foundation For Research Development Activated CD26-high immune cells and CD26-negative immune cells and uses thereof
JP7239179B2 (ja) * 2016-10-05 2023-03-14 ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション,インコーポレイテッド Nk細胞および抗pdl1による癌治療法に関連する方法および組成物
CA3041310C (en) * 2016-10-21 2023-09-05 Altor Bioscience Corporation Multimeric il-15-based molecules
CA3048660A1 (en) 2017-01-03 2018-07-12 Bioatla, Llc Protein therapeutics for treatment of senescent cells
MX2019010172A (es) 2017-02-28 2019-12-18 Affimed Gmbh Combinacion de un anticuerpo anti-cd16a con una citocina.
EP3592778A4 (en) 2017-03-06 2021-01-13 Altor BioScience Corporation IL-15 FUSION PROTEINS SPECIFIC TO IL-12 AND IL-18
US20200188433A1 (en) 2017-03-27 2020-06-18 Nantcell, Inc. aNK AND IL-12 COMPOSITIONS AND METHODS
JP2020533971A (ja) 2017-08-28 2020-11-26 アルター・バイオサイエンス・コーポレーション Il−15をベースとするil−7及びil−21への融合物
EP3844181A1 (en) 2018-08-30 2021-07-07 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
AU2019328575B2 (en) 2018-08-30 2024-07-11 Immunitybio, Inc. Single-chain and multi-chain chimeric polypeptides and uses thereof
CA3108951A1 (en) 2018-08-30 2020-03-05 HCW Biologics, Inc. Single-chain chimeric polypeptides and uses thereof
CA3143035A1 (en) 2019-06-21 2020-12-24 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
CN115380045A (zh) 2020-02-11 2022-11-22 Hcw生物科技公司 激活调节性t细胞的方法
AU2021220870A1 (en) 2020-02-11 2022-08-04 Immunitybio, Inc. Methods of treating age-related and inflammatory diseases
AU2021219720A1 (en) 2020-02-11 2022-08-04 Immunitybio, Inc. Chromatography resin and uses thereof
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders

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