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JPS5780385A - Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine - Google Patents

Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine

Info

Publication number
JPS5780385A
JPS5780385A JP15548580A JP15548580A JPS5780385A JP S5780385 A JPS5780385 A JP S5780385A JP 15548580 A JP15548580 A JP 15548580A JP 15548580 A JP15548580 A JP 15548580A JP S5780385 A JPS5780385 A JP S5780385A
Authority
JP
Japan
Prior art keywords
formula
dialkylxanthine
oxoalkyl
omega
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15548580A
Other languages
Japanese (ja)
Inventor
Makoto Takeda
Eiji Taniyama
Hiroshi Iwane
Yuji Ozawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Petrochemical Co Ltd
Original Assignee
Mitsubishi Petrochemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Petrochemical Co Ltd filed Critical Mitsubishi Petrochemical Co Ltd
Priority to JP15548580A priority Critical patent/JPS5780385A/en
Publication of JPS5780385A publication Critical patent/JPS5780385A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as an ameliorant for microcirculation by an easy operation in one step, by reacting an easily synthesized 1- (ω-haloalkyl)-3,7-dialkylxanthine with a methylating agent and CO in the presence of a carbonylating catalyst.
CONSTITUTION: A compound of formula I (R1 and R2 are 1W4C alkyl; n is an integer 2W6; X is Cl, Br or I) is reacted with a methylating agent, e.g. tetramethyltin, and CO in the presence of a carbonylating catalyst, preferably a palladium complex, to give the aimed compound of formula II. The starting material of formula I is obtained easily by reacting a 1,ω-dihaloalkane of formula III with a 3,7-dialkylxanthine of formula IV under basic conditions.
COPYRIGHT: (C)1982,JPO&Japio
JP15548580A 1980-11-05 1980-11-05 Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine Pending JPS5780385A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15548580A JPS5780385A (en) 1980-11-05 1980-11-05 Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15548580A JPS5780385A (en) 1980-11-05 1980-11-05 Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine

Publications (1)

Publication Number Publication Date
JPS5780385A true JPS5780385A (en) 1982-05-19

Family

ID=15607069

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15548580A Pending JPS5780385A (en) 1980-11-05 1980-11-05 Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine

Country Status (1)

Country Link
JP (1) JPS5780385A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP2963040A1 (en) 2009-09-02 2016-01-06 Concert Pharmaceuticals Inc. Substituted xanthine derivatives
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP2963040A1 (en) 2009-09-02 2016-01-06 Concert Pharmaceuticals Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives

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