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JPS56108787A - Camptothecin coline salt and its preparation - Google Patents

Camptothecin coline salt and its preparation

Info

Publication number
JPS56108787A
JPS56108787A JP942680A JP942680A JPS56108787A JP S56108787 A JPS56108787 A JP S56108787A JP 942680 A JP942680 A JP 942680A JP 942680 A JP942680 A JP 942680A JP S56108787 A JPS56108787 A JP S56108787A
Authority
JP
Japan
Prior art keywords
camptothecin
coline
salt
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP942680A
Other languages
Japanese (ja)
Other versions
JPH0160471B2 (en
Inventor
Haruo Sato
Toshio Kutani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SATO YAKUGAKU KENKYUSHO KK
Yakult Honsha Co Ltd
Original Assignee
SATO YAKUGAKU KENKYUSHO KK
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SATO YAKUGAKU KENKYUSHO KK, Yakult Honsha Co Ltd filed Critical SATO YAKUGAKU KENKYUSHO KK
Priority to JP942680A priority Critical patent/JPS56108787A/en
Publication of JPS56108787A publication Critical patent/JPS56108787A/en
Publication of JPH0160471B2 publication Critical patent/JPH0160471B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The titled compound of formula.
USE: A carcinostatic agent. Water-soluble camptothecin capable of inhibiting the nucleic acid synthesis rapidly and reversibly, and having unique antitumor activity exibiting no cross-tolerance with known carcinostatic agents.
PROCESS: The compound of formula is prepared by suspending camptothecin as starting material in ethanol, adding a coline solution (e.g. 5W30% methanol solution) thereto, and then adding diethyl ether to the mixture.
COPYRIGHT: (C)1981,JPO&Japio
JP942680A 1980-01-31 1980-01-31 Camptothecin coline salt and its preparation Granted JPS56108787A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP942680A JPS56108787A (en) 1980-01-31 1980-01-31 Camptothecin coline salt and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP942680A JPS56108787A (en) 1980-01-31 1980-01-31 Camptothecin coline salt and its preparation

Publications (2)

Publication Number Publication Date
JPS56108787A true JPS56108787A (en) 1981-08-28
JPH0160471B2 JPH0160471B2 (en) 1989-12-22

Family

ID=11720006

Family Applications (1)

Application Number Title Priority Date Filing Date
JP942680A Granted JPS56108787A (en) 1980-01-31 1980-01-31 Camptothecin coline salt and its preparation

Country Status (1)

Country Link
JP (1) JPS56108787A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308560A (en) * 1986-09-18 1994-05-03 M. Y Trondex Limited Process for producing mouldings from an expanded styrene polymer
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
JP2006514071A (en) * 2003-01-03 2006-04-27 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド New anticonvulsant derivative salts
WO2011099507A1 (en) * 2010-02-10 2011-08-18 キッセイ薬品工業株式会社 Salt of fused heterocyclic derivative and crystal thereof

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308560A (en) * 1986-09-18 1994-05-03 M. Y Trondex Limited Process for producing mouldings from an expanded styrene polymer
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5608066A (en) * 1993-02-25 1997-03-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US6107486A (en) * 1993-02-25 2000-08-22 The Stehlin Foundation For Cancer Research Method for purifying 20(S)-camptothecin
US6156897A (en) * 1993-02-25 2000-12-05 The Stehlin Foundation For Cancer Research Method for purifying 20(S)-camptothecin
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6120793A (en) * 1996-01-30 2000-09-19 The Stehlin Foundation For Cancer Research Methods of treating cancer using these derivatives
US6218399B1 (en) 1996-01-30 2001-04-17 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6407239B1 (en) 1999-08-03 2002-06-18 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
JP2006514071A (en) * 2003-01-03 2006-04-27 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド New anticonvulsant derivative salts
WO2011099507A1 (en) * 2010-02-10 2011-08-18 キッセイ薬品工業株式会社 Salt of fused heterocyclic derivative and crystal thereof
CN102753557A (en) * 2010-02-10 2012-10-24 橘生药品工业株式会社 Salt of fused heterocyclic derivative and crystal thereof
JP5337261B2 (en) * 2010-02-10 2013-11-06 キッセイ薬品工業株式会社 Salts and crystals of fused heterocyclic derivatives
US9169266B2 (en) 2010-02-10 2015-10-27 Kissei Pharmaceutical Co., Ltd. Salt of fused heterocyclic derivative and crystal thereof
US9737539B2 (en) 2010-02-10 2017-08-22 Kissei Pharmaceuticals Co., Ltd. Salt of fused heterocyclic derivative and crystal thereof
US10016433B2 (en) 2010-02-10 2018-07-10 Kissei Pharmaceutical Co., Ltd. Salt of fused heterocyclic derivative and crystal thereof
US10576084B2 (en) 2010-02-10 2020-03-03 Kissei Pharmaceutical Co., Ltd. Salt of fused heterocyclic derivative and crystal thereof

Also Published As

Publication number Publication date
JPH0160471B2 (en) 1989-12-22

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