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JPS5576876A - Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne - Google Patents

Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne

Info

Publication number
JPS5576876A
JPS5576876A JP14965978A JP14965978A JPS5576876A JP S5576876 A JPS5576876 A JP S5576876A JP 14965978 A JP14965978 A JP 14965978A JP 14965978 A JP14965978 A JP 14965978A JP S5576876 A JPS5576876 A JP S5576876A
Authority
JP
Japan
Prior art keywords
dimethylxanthine
formula
chloropropane
bromo
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14965978A
Other languages
Japanese (ja)
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Nagatoshi Azuma
Tsuneo Uryu
Hitoshi Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP14965978A priority Critical patent/JPS5576876A/en
Publication of JPS5576876A publication Critical patent/JPS5576876A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound useful as drugs for circulatory diseases at a low coat in short steps, by reacting pentane-2,4-dione with the reaction product between 3,7-dimethylxanthine and 1-bromo-3-chloropropane.
CONSTITUTION: 3,7-Dimethylxanthine of formula II is reacted with 1-bromo-3- chloropropane in the presence of a base, preferably sodium hydroxide, to give 1-(3-chloro-propyl)-3,7-dimethylxanthine of formula I, which is then treated with an alkali halide if necessary, to form a compound of formula III'. The resulting compound is reacted with 1-(5-oxohexyl)-3,7-dimethylxanthine of formula I at a low cost and in short steps.
USE: Effective in treating sequelae due to the cerebral thrombosis.
COPYRIGHT: (C)1980,JPO&Japio
JP14965978A 1978-12-05 1978-12-05 Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne Pending JPS5576876A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14965978A JPS5576876A (en) 1978-12-05 1978-12-05 Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14965978A JPS5576876A (en) 1978-12-05 1978-12-05 Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne

Publications (1)

Publication Number Publication Date
JPS5576876A true JPS5576876A (en) 1980-06-10

Family

ID=15480037

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14965978A Pending JPS5576876A (en) 1978-12-05 1978-12-05 Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne

Country Status (1)

Country Link
JP (1) JPS5576876A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640685A (en) * 1979-09-11 1981-04-16 Maruko Seiyaku Kk Preparation of theobromine derivative
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP2963040A1 (en) 2009-09-02 2016-01-06 Concert Pharmaceuticals Inc. Substituted xanthine derivatives
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640685A (en) * 1979-09-11 1981-04-16 Maruko Seiyaku Kk Preparation of theobromine derivative
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP2963040A1 (en) 2009-09-02 2016-01-06 Concert Pharmaceuticals Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives

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