JPS5610188A - Xanthine derivative and its preparation - Google Patents
Xanthine derivative and its preparationInfo
- Publication number
- JPS5610188A JPS5610188A JP8509679A JP8509679A JPS5610188A JP S5610188 A JPS5610188 A JP S5610188A JP 8509679 A JP8509679 A JP 8509679A JP 8509679 A JP8509679 A JP 8509679A JP S5610188 A JPS5610188 A JP S5610188A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- xanthine derivative
- theobromine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A xanthine derivative of formula I [one of R1WR3 is HC≡C(CH2)n-, (n is 2W5), and the other two are methyl].
EXAMPLE: 1-(5'-Hexynyl)theobromine.
USE: Intermediate of medicines. It has peripheral vessel dilating activity and erythrocyte deformation promoting activity, low toxicity and high solubilty, and is useful as an intermediate of a pharmaceutically valuable xanthine derivative (e.g. pentoxifylline).
PROCESS: The compound of formula I is prepared by reacting an easily available compound of formula II (one of R4WR6 is H and the other two are methyl) with an alkyne derivative of formula HC≡C(CH2)nX (X is halogen, etc.). The compound of formula II is, e.g. theobromine, theophylline, etc. The hydration of the titled compound gives a pharmaceutical agent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8509679A JPS5610188A (en) | 1979-07-06 | 1979-07-06 | Xanthine derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8509679A JPS5610188A (en) | 1979-07-06 | 1979-07-06 | Xanthine derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5610188A true JPS5610188A (en) | 1981-02-02 |
Family
ID=13849070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8509679A Pending JPS5610188A (en) | 1979-07-06 | 1979-07-06 | Xanthine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5610188A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5201590A (en) * | 1990-10-01 | 1993-04-13 | Fuji Photo Film Co., Ltd. | Image recording apparatus |
| WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| WO2013155465A1 (en) | 2012-04-13 | 2013-10-17 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| EP3199203A1 (en) | 2008-02-29 | 2017-08-02 | Concert Pharmaceuticals Inc. | Substitued xanthine derivatives |
-
1979
- 1979-07-06 JP JP8509679A patent/JPS5610188A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5201590A (en) * | 1990-10-01 | 1993-04-13 | Fuji Photo Film Co., Ltd. | Image recording apparatus |
| EP3199203A1 (en) | 2008-02-29 | 2017-08-02 | Concert Pharmaceuticals Inc. | Substitued xanthine derivatives |
| WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| WO2013155465A1 (en) | 2012-04-13 | 2013-10-17 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
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