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JPS54112897A - 1*2*3*3a*8*8aahexahydropyrrolo*2*33b*indole derivative*its manufacture and analgesic composition containing it - Google Patents

1*2*3*3a*8*8aahexahydropyrrolo*2*33b*indole derivative*its manufacture and analgesic composition containing it

Info

Publication number
JPS54112897A
JPS54112897A JP11470178A JP11470178A JPS54112897A JP S54112897 A JPS54112897 A JP S54112897A JP 11470178 A JP11470178 A JP 11470178A JP 11470178 A JP11470178 A JP 11470178A JP S54112897 A JPS54112897 A JP S54112897A
Authority
JP
Japan
Prior art keywords
manufacture
composition containing
indole derivative
analgesic composition
analgesic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11470178A
Other languages
English (en)
Japanese (ja)
Inventor
Barutorini Aresandoro
Renchi Giobani
Gari Aresandoro
Aiero Nee Marumuberuku Petora
Barutorini Nee Piza Rozaria
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAPOLI, University of
Original Assignee
NAPOLI, University of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAPOLI, University of filed Critical NAPOLI, University of
Publication of JPS54112897A publication Critical patent/JPS54112897A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP11470178A 1977-09-20 1978-09-20 1*2*3*3a*8*8aahexahydropyrrolo*2*33b*indole derivative*its manufacture and analgesic composition containing it Pending JPS54112897A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT09574/77A IT1109003B (it) 1977-09-20 1977-09-20 Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo

Publications (1)

Publication Number Publication Date
JPS54112897A true JPS54112897A (en) 1979-09-04

Family

ID=11132370

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11470178A Pending JPS54112897A (en) 1977-09-20 1978-09-20 1*2*3*3a*8*8aahexahydropyrrolo*2*33b*indole derivative*its manufacture and analgesic composition containing it

Country Status (7)

Country Link
JP (1) JPS54112897A (fr)
AR (1) AR222311A1 (fr)
CA (1) CA1125657A (fr)
DE (1) DE2839279A1 (fr)
FR (1) FR2434167A1 (fr)
GB (1) GB2005259B (fr)
IT (1) IT1109003B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323881A (ja) * 1986-07-16 1988-02-01 ヘキスト−ルセル・フア−マシユウテイカルズ・インコ−ポレイテツド １，２，３，３ａ，８，８ａ−ヘキサヒドロ−３ａ，８（および１，３ａ，８）−ジ（およびトリ）メチルピロロ〔２，３−ｂ〕インド−ルおよびそれらの製造法
JPS6425777A (en) * 1987-04-03 1989-01-27 Mediolanum Farmaceut Srl Organic salt of physostigmine
JPH02289572A (ja) * 1989-03-27 1990-11-29 Hoechst Roussel Pharmaceut Inc エセロリンの炭酸エステル誘導体およびその製造方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
GB8616089D0 (en) * 1986-07-02 1986-08-06 Univ Manchester Organic compounds
AT400331B (de) * 1987-05-15 1995-12-27 Hoechst Roussel Pharma 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b)indole, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5206260A (en) * 1991-11-07 1993-04-27 Merck & Co., Inc. Hexahydropyrrolo[2,3-b]indole derivatives
GB9205670D0 (en) * 1992-03-16 1992-04-29 Indena Spa New derivatives of physostigmine,their use and pharmaceutical formulations containing them
NZ503773A (en) 1997-10-10 2002-05-31 Chiese Farmaceutici S A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity
US6495700B1 (en) * 2002-01-09 2002-12-17 Axonyx, Inc. Process for producing phenserine and its analog

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323881A (ja) * 1986-07-16 1988-02-01 ヘキスト−ルセル・フア−マシユウテイカルズ・インコ−ポレイテツド １，２，３，３ａ，８，８ａ−ヘキサヒドロ−３ａ，８（および１，３ａ，８）−ジ（およびトリ）メチルピロロ〔２，３−ｂ〕インド−ルおよびそれらの製造法
JPS6425777A (en) * 1987-04-03 1989-01-27 Mediolanum Farmaceut Srl Organic salt of physostigmine
JPH02289572A (ja) * 1989-03-27 1990-11-29 Hoechst Roussel Pharmaceut Inc エセロリンの炭酸エステル誘導体およびその製造方法

Also Published As

Publication number Publication date
GB2005259A (en) 1979-04-19
GB2005259B (en) 1982-06-23
IT1109003B (it) 1985-12-16
CA1125657A (fr) 1982-06-15
DE2839279A1 (de) 1979-03-29
FR2434167B1 (fr) 1983-03-18
AR222311A1 (es) 1981-05-15
FR2434167A1 (fr) 1980-03-21

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