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CA1125657A - Derives du 1,2,3,3a,8,8a-hexahydropyrrolo ¬2,3-b| indole - Google Patents

Derives du 1,2,3,3a,8,8a-hexahydropyrrolo ¬2,3-b| indole

Info

Publication number
CA1125657A
CA1125657A CA311,555A CA311555A CA1125657A CA 1125657 A CA1125657 A CA 1125657A CA 311555 A CA311555 A CA 311555A CA 1125657 A CA1125657 A CA 1125657A
Authority
CA
Canada
Prior art keywords
acid
eseroline
formula
hexahydropyrrolo
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA311,555A
Other languages
English (en)
Inventor
Alessandro Bartolini
Giovanni Renzi
Alessandro Galli
Petra Nee Malmberg Aiello
Rosalia Nee Piazzo Bartolini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Firenze
Original Assignee
Universita degli Studi di Firenze
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Firenze filed Critical Universita degli Studi di Firenze
Priority to CA000399054A priority Critical patent/CA1137489A/fr
Application granted granted Critical
Publication of CA1125657A publication Critical patent/CA1125657A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA311,555A 1977-09-20 1978-09-19 Derives du 1,2,3,3a,8,8a-hexahydropyrrolo ¬2,3-b| indole Expired CA1125657A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000399054A CA1137489A (fr) 1977-09-20 1982-03-22 Derives de 1,2,3,3a,8,8a-hexahydropyrrolo (2,3-b) indole

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT09574/77A IT1109003B (it) 1977-09-20 1977-09-20 Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo
IT9574A/77 1977-09-20

Publications (1)

Publication Number Publication Date
CA1125657A true CA1125657A (fr) 1982-06-15

Family

ID=11132370

Family Applications (1)

Application Number Title Priority Date Filing Date
CA311,555A Expired CA1125657A (fr) 1977-09-20 1978-09-19 Derives du 1,2,3,3a,8,8a-hexahydropyrrolo ¬2,3-b| indole

Country Status (7)

Country Link
JP (1) JPS54112897A (fr)
AR (1) AR222311A1 (fr)
CA (1) CA1125657A (fr)
DE (1) DE2839279A1 (fr)
FR (1) FR2434167A1 (fr)
GB (1) GB2005259B (fr)
IT (1) IT1109003B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
GB8616089D0 (en) * 1986-07-02 1986-08-06 Univ Manchester Organic compounds
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1225462B (it) * 1987-04-03 1990-11-14 Mediolanum Farmaceutici Srl Sali organici di derivati della fisostigmina
AT400331B (de) * 1987-05-15 1995-12-27 Hoechst Roussel Pharma 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b)indole, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4971992A (en) * 1989-03-27 1990-11-20 Hoechst-Roussel Pharmaceuticals Inc. Carbonate derivatives of eseroline
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5206260A (en) * 1991-11-07 1993-04-27 Merck & Co., Inc. Hexahydropyrrolo[2,3-b]indole derivatives
GB9205670D0 (en) * 1992-03-16 1992-04-29 Indena Spa New derivatives of physostigmine,their use and pharmaceutical formulations containing them
NZ503773A (en) * 1997-10-10 2002-05-31 Chiese Farmaceutici S A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity
US6495700B1 (en) * 2002-01-09 2002-12-17 Axonyx, Inc. Process for producing phenserine and its analog

Also Published As

Publication number Publication date
IT1109003B (it) 1985-12-16
GB2005259B (en) 1982-06-23
AR222311A1 (es) 1981-05-15
FR2434167B1 (fr) 1983-03-18
JPS54112897A (en) 1979-09-04
DE2839279A1 (de) 1979-03-29
FR2434167A1 (fr) 1980-03-21
GB2005259A (en) 1979-04-19

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