JPH08512297A - ヨウ素化オリゴマー化合物およびこれを含む診断用組成物 - Google Patents
ヨウ素化オリゴマー化合物およびこれを含む診断用組成物Info
- Publication number
- JPH08512297A JPH08512297A JP7503801A JP50380194A JPH08512297A JP H08512297 A JPH08512297 A JP H08512297A JP 7503801 A JP7503801 A JP 7503801A JP 50380194 A JP50380194 A JP 50380194A JP H08512297 A JPH08512297 A JP H08512297A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- amino
- group
- formula
- tris
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93A001479 | 1993-07-08 | ||
IT93MI001479A IT1264690B1 (it) | 1993-07-08 | 1993-07-08 | Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi |
PCT/EP1994/002111 WO1995001966A1 (en) | 1993-07-08 | 1994-06-29 | Iodinated oligomeric compounds and diagnostic compositions containing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH08512297A true JPH08512297A (ja) | 1996-12-24 |
Family
ID=11366554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7503801A Pending JPH08512297A (ja) | 1993-07-08 | 1994-06-29 | ヨウ素化オリゴマー化合物およびこれを含む診断用組成物 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0707572A1 (it) |
JP (1) | JPH08512297A (it) |
AU (1) | AU7125194A (it) |
IL (1) | IL110249A0 (it) |
IS (1) | IS4189A (it) |
IT (1) | IT1264690B1 (it) |
WO (1) | WO1995001966A1 (it) |
ZA (1) | ZA944923B (it) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009529493A (ja) * | 2006-02-15 | 2009-08-20 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
JP2009531286A (ja) * | 2006-02-14 | 2009-09-03 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
JP2009536943A (ja) * | 2006-05-11 | 2009-10-22 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2200495A1 (en) * | 1994-09-22 | 1996-03-28 | Guerbet S.A. | Polyiodo compounds, their preparation and their use in x-ray radiology |
PL314490A1 (en) * | 1994-09-22 | 1996-09-16 | Guerbet Sa | Iodinated derivatives, method of obtaining and using them as contrasting agents in x-raying |
IT1271134B (it) * | 1994-12-01 | 1997-05-26 | Bracco Spa | Derivati iodurati del bifenile e loro impiego diagnostico |
DE19740403C2 (de) * | 1997-09-09 | 1999-11-11 | Schering Ag | Neue Kontrastmittel |
EP1549322B1 (en) * | 2002-05-09 | 2010-02-17 | Oncothyreon Inc. | Lipid a and other carbohydrate ligand analogs |
NO20055702D0 (no) | 2005-12-02 | 2005-12-02 | Amersham Health As | Contrast agents |
EP1986993B1 (en) * | 2006-02-14 | 2012-12-05 | Ge Healthcare As | Contrast agents |
EP2021317A1 (en) * | 2006-05-11 | 2009-02-11 | GE Healthcare AS | Contrast agents |
US7662859B2 (en) | 2007-02-16 | 2010-02-16 | Ge Healthcare As | Contrast agents |
WO2008123779A1 (en) * | 2007-04-04 | 2008-10-16 | Ge Healthcare As | Trisubstituted triazamacrocycli c compounds and their use as contrast agents |
NO20073382L (no) * | 2007-06-29 | 2008-12-30 | Ge Healthcare As | Contrast Agents |
US8202511B2 (en) | 2007-10-12 | 2012-06-19 | Ge Healthcare As | Contrast agents |
CN103781469B (zh) | 2011-02-24 | 2015-09-16 | 肿瘤防护公司 | 含有佐剂的以muc1为基础的糖脂肽疫苗 |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
US10975060B2 (en) | 2016-11-28 | 2021-04-13 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
CN106928087B (zh) * | 2017-03-13 | 2019-01-22 | 牡丹江医学院 | 一种ct胃肠道造影剂及其应用 |
PE20211471A1 (es) | 2018-11-23 | 2021-08-05 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos |
EP4015509A1 (en) * | 2020-12-18 | 2022-06-22 | Justesa Imagen S.A.U | Organometallic compounds and their use as multimodal contrasting media for imaging diagnosis |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4065553A (en) * | 1974-05-31 | 1977-12-27 | Laboratoires Andre Guerbet | X-Ray contrast media |
GB1491129A (en) * | 1975-06-04 | 1977-11-09 | Guerbet Sa | Iodo-benzene derivatives and an x-ray contrast medium containing them |
US5162109A (en) * | 1990-09-13 | 1992-11-10 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
US5019371A (en) * | 1990-11-21 | 1991-05-28 | Mallinckrodt Medical, Inc. | Novel x-ray contrast agents, compositions and methods |
-
1993
- 1993-07-08 IT IT93MI001479A patent/IT1264690B1/it active IP Right Grant
-
1994
- 1994-06-29 JP JP7503801A patent/JPH08512297A/ja active Pending
- 1994-06-29 AU AU71251/94A patent/AU7125194A/en not_active Abandoned
- 1994-06-29 WO PCT/EP1994/002111 patent/WO1995001966A1/en not_active Application Discontinuation
- 1994-06-29 EP EP94920471A patent/EP0707572A1/en not_active Withdrawn
- 1994-07-07 IL IL11024994A patent/IL110249A0/xx unknown
- 1994-07-07 ZA ZA944923A patent/ZA944923B/xx unknown
- 1994-07-07 IS IS4189A patent/IS4189A/is unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009531286A (ja) * | 2006-02-14 | 2009-09-03 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
JP2009529493A (ja) * | 2006-02-15 | 2009-08-20 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
JP2009536943A (ja) * | 2006-05-11 | 2009-10-22 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
Also Published As
Publication number | Publication date |
---|---|
IS4189A (is) | 1995-01-09 |
WO1995001966A1 (en) | 1995-01-19 |
IL110249A0 (en) | 1994-10-21 |
ITMI931479A0 (it) | 1993-07-08 |
EP0707572A1 (en) | 1996-04-24 |
ITMI931479A1 (it) | 1995-01-08 |
IT1264690B1 (it) | 1996-10-04 |
AU7125194A (en) | 1995-02-06 |
ZA944923B (en) | 1995-03-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH08512297A (ja) | ヨウ素化オリゴマー化合物およびこれを含む診断用組成物 | |
JP2675058B2 (ja) | テトラ醋酸配位化合物及びその製造方法 | |
JP2569144B2 (ja) | 新規ジカルボン酸ービス(3,5ージカルバモイルー2,4,6ートリヨードーアニリド)、その製法及びこれを含有するレントゲン造影剤 | |
JP5290773B2 (ja) | 造影剤 | |
JPH05502230A (ja) | 非イオン性x線造影剤、組成物及び方法 | |
JP2977613B2 (ja) | 1,3−ビス−[3−(モノ−またはポリ−ヒドロキシ)アシルアミノ−5−(モノ−またはポリ−ヒドロキシアルキル)アミノカルボニル−2,4,6−トリヨ−ド−ベンゾイル−アミノ]−ヒドロキシ−またはヒドロキシアルキル−プロパン類、それらの製造法、およびそれらを含有する造影剤 | |
KR19990063025A (ko) | 치환된 폴리아미노카르복시산 마크로사이클의 금속 킬레이트 및 화상진단에 있어서 그의 용도 | |
JP7145156B2 (ja) | 二量体造影剤 | |
JP6375231B2 (ja) | 新しいクラスのジアゼピン誘導体キレート化剤およびmri造影剤としてのその常磁性金属との錯体 | |
JP3249112B2 (ja) | 非イオン性化合物及び該化合物を含有する放射線造影剤組成物 | |
JPH09507210A (ja) | 新規なx線造影剤,組成物および方法 | |
FI93209B (fi) | Substituoituja dikarboksyylihappo-bis(3,5-dikarbamoyyli-2,4,6-trijodianilideja) menetelmä niiden valmistamiseksi sekä niiden käyttö röntgenvarjoaineiden valmistamiseksi | |
JPH10505851A (ja) | ポリヨウ素化化合物、その製法、およびx線放射線医学におけるその使用 | |
JPH10503777A (ja) | ダイマーのdtpa誘導体及びその金属複合体、これらの複合体を含む医薬剤、それらの診断及び治療における使用並びに前記複合体及び医薬剤を製造するための方法 | |
JP4582918B2 (ja) | 造影剤 | |
DE4341724A1 (de) | Halogenaryl-substituierte Metallkomplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel | |
AU764788C (en) | Contrast media for angiography | |
US5616312A (en) | Thiol ligands and complexes for X-ray imaging | |
JPH07501809A (ja) | 非イオン性x線造影剤組成物およびその製造方法 | |
WO2008123779A1 (en) | Trisubstituted triazamacrocycli c compounds and their use as contrast agents | |
TW200539894A (en) | Trimeric, macrocyclically substituted halo-benzene derivatives | |
JPH08283189A (ja) | ビフェニルヨード化誘導体およびそれらの診断用途 | |
CN101820924A (zh) | 造影剂 | |
DE19731591A1 (de) | Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie | |
DE19740403C2 (de) | Neue Kontrastmittel |