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JPH08512297A - ヨウ素化オリゴマー化合物およびこれを含む診断用組成物 - Google Patents

ヨウ素化オリゴマー化合物およびこれを含む診断用組成物

Info

Publication number
JPH08512297A
JPH08512297A JP7503801A JP50380194A JPH08512297A JP H08512297 A JPH08512297 A JP H08512297A JP 7503801 A JP7503801 A JP 7503801A JP 50380194 A JP50380194 A JP 50380194A JP H08512297 A JPH08512297 A JP H08512297A
Authority
JP
Japan
Prior art keywords
hydroxy
amino
group
formula
tris
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7503801A
Other languages
English (en)
Japanese (ja)
Inventor
アネリ、ピエル、ルチオ
ブロケッタ、マリノ
ハーエン、クリストフ デ
ガツォッティ、オルネラ
ウッゼリ、フルヴィオ
ヴェロナ、サンドラ
ヴィシガリー、マッシモ
Original Assignee
ブラッコ エッセ.ピ.ア.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブラッコ エッセ.ピ.ア. filed Critical ブラッコ エッセ.ピ.ア.
Publication of JPH08512297A publication Critical patent/JPH08512297A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/50Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D255/00Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP7503801A 1993-07-08 1994-06-29 ヨウ素化オリゴマー化合物およびこれを含む診断用組成物 Pending JPH08512297A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT93A001479 1993-07-08
IT93MI001479A IT1264690B1 (it) 1993-07-08 1993-07-08 Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi
PCT/EP1994/002111 WO1995001966A1 (en) 1993-07-08 1994-06-29 Iodinated oligomeric compounds and diagnostic compositions containing the same

Publications (1)

Publication Number Publication Date
JPH08512297A true JPH08512297A (ja) 1996-12-24

Family

ID=11366554

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7503801A Pending JPH08512297A (ja) 1993-07-08 1994-06-29 ヨウ素化オリゴマー化合物およびこれを含む診断用組成物

Country Status (8)

Country Link
EP (1) EP0707572A1 (it)
JP (1) JPH08512297A (it)
AU (1) AU7125194A (it)
IL (1) IL110249A0 (it)
IS (1) IS4189A (it)
IT (1) IT1264690B1 (it)
WO (1) WO1995001966A1 (it)
ZA (1) ZA944923B (it)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529493A (ja) * 2006-02-15 2009-08-20 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
JP2009531286A (ja) * 2006-02-14 2009-09-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
JP2009536943A (ja) * 2006-05-11 2009-10-22 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2200495A1 (en) * 1994-09-22 1996-03-28 Guerbet S.A. Polyiodo compounds, their preparation and their use in x-ray radiology
PL314490A1 (en) * 1994-09-22 1996-09-16 Guerbet Sa Iodinated derivatives, method of obtaining and using them as contrasting agents in x-raying
IT1271134B (it) * 1994-12-01 1997-05-26 Bracco Spa Derivati iodurati del bifenile e loro impiego diagnostico
DE19740403C2 (de) * 1997-09-09 1999-11-11 Schering Ag Neue Kontrastmittel
EP1549322B1 (en) * 2002-05-09 2010-02-17 Oncothyreon Inc. Lipid a and other carbohydrate ligand analogs
NO20055702D0 (no) 2005-12-02 2005-12-02 Amersham Health As Contrast agents
EP1986993B1 (en) * 2006-02-14 2012-12-05 Ge Healthcare As Contrast agents
EP2021317A1 (en) * 2006-05-11 2009-02-11 GE Healthcare AS Contrast agents
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
WO2008123779A1 (en) * 2007-04-04 2008-10-16 Ge Healthcare As Trisubstituted triazamacrocycli c compounds and their use as contrast agents
NO20073382L (no) * 2007-06-29 2008-12-30 Ge Healthcare As Contrast Agents
US8202511B2 (en) 2007-10-12 2012-06-19 Ge Healthcare As Contrast agents
CN103781469B (zh) 2011-02-24 2015-09-16 肿瘤防护公司 含有佐剂的以muc1为基础的糖脂肽疫苗
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US10975060B2 (en) 2016-11-28 2021-04-13 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
CN106928087B (zh) * 2017-03-13 2019-01-22 牡丹江医学院 一种ct胃肠道造影剂及其应用
PE20211471A1 (es) 2018-11-23 2021-08-05 Bayer Ag Formulacion de medios de contraste y proceso para prepararlos
EP4015509A1 (en) * 2020-12-18 2022-06-22 Justesa Imagen S.A.U Organometallic compounds and their use as multimodal contrasting media for imaging diagnosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065553A (en) * 1974-05-31 1977-12-27 Laboratoires Andre Guerbet X-Ray contrast media
GB1491129A (en) * 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009531286A (ja) * 2006-02-14 2009-09-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
JP2009529493A (ja) * 2006-02-15 2009-08-20 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
JP2009536943A (ja) * 2006-05-11 2009-10-22 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤

Also Published As

Publication number Publication date
IS4189A (is) 1995-01-09
WO1995001966A1 (en) 1995-01-19
IL110249A0 (en) 1994-10-21
ITMI931479A0 (it) 1993-07-08
EP0707572A1 (en) 1996-04-24
ITMI931479A1 (it) 1995-01-08
IT1264690B1 (it) 1996-10-04
AU7125194A (en) 1995-02-06
ZA944923B (en) 1995-03-14

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