JP6647939B2 - Automatic analyzer - Google Patents

Description

  Embodiments of the present invention relate to an automatic analyzer.

  Laboratory tests are performed to objectively evaluate the condition of a subject. A clinical test device is mainly used for this clinical test. An example of a clinical test device is an automatic analyzer.

  The automatic analyzer dispenses a test sample such as blood or urine and a reagent into a reaction tube, mixes and reacts them, and then measures (examines) a change in color tone or turbidity caused by the reaction. Thereby, the concentration and activity of the test substance (measurement item) in the test sample are measured.

  The automatic analyzer uses a calibration sample (calibration sample) having a known concentration or activity of a substance to be measured and a calibration curve obtained from the reagent and the analyte (measurement item) in the test sample. ) Measure the concentration and activity.

  Among the measurement items, there are, for example, items for which LCAT (lecitin-cholesterol acyltransferase, lecithin-cholesterol acyltransferase), lactic acid, and the like are respectively measured, and the period from the last measurement is long. Before this measurement, a quality control sample (control sample) having a known concentration and activity of the substance to be measured is measured, and quality control is performed by collating with a calibration curve (quality control measurement). Then, when it is determined that sufficient accuracy is obtained, the measurement of the test sample is performed. Note that the calibration sample and the quality control sample have in common that the concentration and activity of the substance to be measured are known, but they are used for different purposes. Therefore, usually, the calibration sample and the quality control sample are managed separately from each other in the automatic analyzer.

Japanese Patent No. 4619892

  Conventionally, during the quality control measurement, the measurement of the test sample is temporarily stopped, and if there is no problem with the quality control measurement, the measurement of the test sample may be started. In this case, the test sample has been left in the automatic analyzer for a long time. When it was determined that there was a problem with the results of the quality control measurement, the test sample was sometimes discharged without being measured again. In addition, quality control measurement may be performed on a measurement item having a short period from the previous measurement, and a large amount of quality control sample may be consumed.

  The problem to be solved by the present invention is to provide an automatic analyzer that can easily perform quality control on a measurement item that has a long period from the last measurement.

  The automatic analyzer according to the embodiment includes a storage unit, a calculation unit, a determination unit, and a display unit. The storage unit stores measurement history information indicating a measurement history for each measurement item. The calculation unit calculates, based on the measurement history information, a measurement blank period that is an elapsed period from the previous measurement for the measurement item for which the measurement instruction has been received. The determination unit determines whether or not the measurement blank period of the measurement item for which the measurement instruction has been received is equal to or longer than a predetermined period based on the measurement blank period and a predetermined period. The display unit, when the determination unit determines that the measurement blank period of the measurement item for which the measurement instruction has been received is longer than the predetermined period, displays quality control recommendation information for recommending measurement of the quality control sample related to the measurement item. I do.

FIG. 2 is a block diagram showing a functional configuration of the automatic analyzer according to the embodiment. FIG. 2 is a schematic diagram illustrating an outline of an analysis module of the automatic analyzer according to the embodiment. The schematic diagram which shows the outline of the rack set layout which concerns on embodiment. 5 is a flowchart showing the operation of the automatic analyzer according to the embodiment. 5 is a flowchart showing the operation of the automatic analyzer according to the embodiment.

  Hereinafter, an automatic analyzer according to an embodiment will be described with reference to the drawings.

  FIG. 1 is a block diagram illustrating a functional configuration of the automatic analyzer 1 according to the embodiment. The automatic analyzer 1 has an analysis module 2, a storage circuit 3, a processing circuit 4, a display 5, and an input circuit 6.

  FIG. 2 is a schematic diagram illustrating an outline of the analysis module 2 of the automatic analyzer 1 according to the embodiment. The analysis module 2 includes a first reagent bottle 21a, a second reagent bottle 21b, a first reagent rack 22a, a second reagent rack 22b, a first reagent storage 23a, a second reagent storage 23b, a reaction tube 24, a reaction disk 25, and a sample. It has a container 26, a rack 27, a first dispensing arm 28a, a second dispensing arm 28b, a sampling arm 29, a stirring unit 30, a photometric unit 31, and a washing unit 32.

  The first reagent bottle 21a contains a first reagent that reacts with the sample. The second reagent bottle 21b contains a second reagent that is a different type of reagent from the first reagent. The first reagent rack 22a is installed in the first reagent storage 23a with a plurality of first reagent bottles 21a accommodated therein. The second reagent rack 22b is installed in the second reagent storage 23b with a plurality of second reagent bottles 21b accommodated therein.

  The reaction tube 24 is a container used when the sample reacts with the first reagent and the second reagent. A plurality of reaction tubes 24 are arranged in a circle on the reaction disk 25.

  The sample container 26 is a container that stores a sample. One sample container 26 contains a test sample such as blood or urine, a calibration sample or a quality control sample whose concentration and activity of the substance to be measured are known as the sample. A plurality of sample containers 26 are arranged on the rack 27. The rack 27 is loaded, for example, on the upstream side (the right side of the rail R in FIG. 2), which is a general transport mechanism, and then on the downstream side (the left side of the rail R in FIG. 2). Is done. Each of the sample containers 26 is individually provided with an identification code such as a barcode and can be individually managed.

  The first reagent is dispensed by the first dispensing arm 28a from the inside of the first reagent bottle 21a into the reaction tube 24 where the sample is dispensed. The second reagent is dispensed from the second reagent bottle 21b into the reaction tube 24 where the sample and the first reagent are dispensed by the second dispensing arm 28b.

  The reaction tube 24 into which the sample and the first reagent are dispensed, and the reaction tube 24 into which the sample, the first reagent, and the second reagent are dispensed, are rotated by the rotation of the reaction disk 25 to position the stirring unit 30. Moved to The stirring unit 30 stirs the sample in the reaction tube 24 and the first reagent, and stirs the sample in the reaction tube 24 with the first reagent and the second reagent, so that the sample, the first reagent and the second reagent are stirred. This is a unit for mixing with a reagent.

  The reaction tube 24 containing the agitated sample and the first and second reagents is moved to the position of the photometric unit 31 by the rotation of the reaction disk 25. The photometric unit 31 irradiates the reaction tube 24 with light, and measures a change in absorbance of a mixed solution of the sample, the first reagent, and the second reagent.

  The cleaning unit 32 cleans the inside of the reaction tube 24 after the mixed solution in the reaction tube 24 whose measurement has been completed is discarded. This is the end of the description of the analysis module 2.

  In the automatic analyzer 1 shown in FIG. 1, the components and the respective processing functions performed by the calculation unit / judgment unit are recorded in the storage circuit 3 in the form of a program executable by a computer. The processing circuit 4 is a processor that reads out a program from a memory and executes the program to realize a function corresponding to each program. In other words, the processing circuit 4 in a state where each program is read has each function shown in the processing circuit 4 of FIG.

  Here, a description will be given assuming that the processing functions performed by the calculation unit / judgment unit are realized by a single processing circuit 4. However, it is assumed that a plurality of separated processors are combined and each processor executes a program. The function may be realized by using.

  The term “processor” in this specification refers to, for example, a dedicated or general-purpose CPU (Central Processing Unit) arithmetic circuit (circuitry), or an application-specific integrated circuit (Application Specific Integrated Circuit, such as an AIC (Logical Integrated Circuit: AIC)). , Simple Programmable Logic Device (SPLD), Composite Programmable Logic Device (CPLD), and Field Programmable Gate Array (FPGA) It refers to the circuit and the like. The processor realizes functions by reading and executing a program stored in a memory or directly incorporated in a circuit of the processor. The memory for storing the program may be provided separately for each processor, or the storage circuit 3 in FIG. 1 may store a program corresponding to the function of each processor. For the configuration of the storage circuit 3, for example, a storage device such as a general RAM (Random Access Memory) or a HDD (Hard Disc Drive) is applied.

  Note that each processor of the present embodiment is not limited to the case where each processor is configured as a single circuit, but may be configured as one processor by combining a plurality of independent circuits to realize its function. Good. Further, a plurality of components in FIG. 1 may be integrated into one processor to realize its function.

  An example of the storage unit in the claims corresponds to the storage circuit 3 in the present embodiment. An example of the calculation unit in the claims corresponds to the calculation function 41 in the present embodiment. An example of the determining unit in the claims corresponds to the determining function 42.

  The input circuit 6 is a circuit generally used for a trackball, a switch button, a mouse, a keyboard, and the like. The input circuit 6 is communicably connected to the processing circuit 4. The input circuit 6 converts an input operation received from the operator into an electric signal and outputs the electric signal to the processing circuit 4.

  The storage circuit 3 stores measurement history information indicating a measurement history for each measurement item. For example, the storage circuit 3 stores, as measurement history information, the latest measurement time as the last measurement time for each measurement item. The storage circuit 3 stores, for each measurement item, a time when an electric signal indicating a measurement item related to the measurement instruction input by the operator is received. At this time, a general clock function may be applied to the storage circuit 3, and the clock method of the time is not limited at all. Further, regarding the storage of the time, the storage circuit 3 may store the latest time of the measurement item as measurement history information. Therefore, the storage method in the storage circuit 3 may be either overwrite storage or stock storage.

  The processing circuit 4 calculates a measurement blank period, which is an elapsed period from the previous measurement, for the measurement item for which the measurement instruction has been received (calculation function 41). At this time, the processing circuit 4 calculates the measurement blank period based on the latest measurement time and the measurement instruction time that is the time when the measurement instruction was received. The processing circuit 4 reads from the storage circuit 3 the latest measurement time of the measurement item related to the measurement instruction input by the operator. The processing circuit 4 specifies the measurement instruction time by a general clock function. The processing circuit 4 calculates a period between the read latest measurement time and the measurement instruction time as a measurement blank period.

  The processing circuit 4 determines whether or not the measurement blank period of the measurement item for which the measurement instruction has been received is equal to or longer than a predetermined period based on the measurement blank period and a predetermined period. This predetermined period is input in advance for each measurement item by an input operation by the operator, for example, and is stored in the storage circuit 3. The processing circuit 4 compares the predetermined period corresponding to the measurement item for which the measurement instruction has been received with the calculated measurement blank period. Accordingly, the processing circuit 4 determines whether the measurement blank period of the measurement item for which the measurement instruction has been received is equal to or longer than a predetermined period. Determining that the measurement blank period of the measurement item for which the measurement instruction has been received is equal to or longer than the predetermined period corresponds to determining that the measurement item has a long period since the last measurement. When the processing circuit 4 determines that the measurement blank period of the measurement item for which the measurement instruction has been received is equal to or longer than the predetermined period, the processing circuit 4 outputs a control signal indicating this determination to the display 5 together with the measurement item.

  The display 5 is configured by a general display device such as an LCD (Liquid Crystal Display) and an organic EL (Electroluminescence) display. The display 5 corresponds to an example of a display unit in the claims.

  When the processing circuit 4 determines that the measurement blank period of the measurement item for which the measurement instruction has been received is equal to or longer than the predetermined period by the processing circuit 4, the display 5 displays quality control recommendation information for recommending measurement of the quality control sample related to the measurement item. indicate. At this time, the display 5 displays the quality management recommendation information based on the control signal from the processing circuit 4. The quality control recommended information may be any information that informs the operator that the measurement item has a long period from the previous measurement and is a measurement item that requires quality control measurement. As long as the information indicates this content, the specific information format of the quality management recommended information may be appropriately designed such as text information or image information. The operator recognizes from the quality control recommendation information that the measurement item has a long period since the previous measurement and is a measurement item that requires quality control measurement. Thus, the operator can operate the input circuit 6 to perform an operation input for performing quality control measurement.

  The display 5 may display information for recommending the introduction of the quality control sample as the quality control recommended information. For example, the display 5 receives an operation input for performing the quality control measurement, and displays information indicating a rack set layout for the quality control measurement. FIG. 3 is a schematic diagram showing an outline of a rack set layout. The frame line 271 schematically shows the rack 27. Positions A to E indicate positions on the rack 27 where the sample containers 26 are installed. In FIG. 3, information recommending that the quality control sample is set at the position A and the position B, and that the test sample is set at the position C, the position D, and the position E and the rack is inserted is displayed. An example is shown. Thereby, the operator can insert the quality control sample while grasping the installation position of the quality control sample based on this information.

  Further, when the processing circuit 4 determines that the measurement blank period is equal to or longer than the predetermined period, the processing circuit 4 may further determine whether or not the quality control sample has been input. For example, the processing circuit 4 reads an identification code such as a bar code attached to each sample container 26. The processing circuit 4 determines whether or not the sample container 26 containing the quality control sample is loaded based on the read identification code. When the processing circuit 4 determines that the quality control sample has not been input, the processing circuit 4 outputs a control signal indicating this determination to the display 5 together with the measurement item.

  The display 5 displays first warning information relating to the measurement result of the measurement item when the processing circuit 4 determines that the quality control sample has not been input. At this time, the display 5 displays the first warning information based on the control signal from the processing circuit 4. The first warning information may be any information as long as it informs the operator that the quality control sample has not been loaded. As long as the information indicates this content, the specific information format of the first warning information may be appropriately designed such as text information or image information. The operator can know from the first warning information that the quality control sample has not been loaded.

  Further, when the processing circuit 4 determines that the measurement blank period is equal to or longer than the predetermined period, the processing circuit 4 may further determine whether or not the measurement of the quality control sample has been performed. For example, the processing circuit 4 reads an identification code attached to each sample container 26. The processing circuit 4 specifies the sample container 26 containing the quality control sample based on the read identification code, and measures the measurement result of the sample dispensed from the sample container 26 by the sampling arm 29 (that is, the quality control measurement). When the result is obtained, it is determined that the measurement of the quality control sample has been performed. When the result of the quality control measurement cannot be obtained, the processing circuit 4 determines that the quality control sample has not been measured. When determining that the measurement of the quality control sample is not performed, the processing circuit 4 outputs a control signal indicating a control signal indicating the determination to the display 5 together with the measurement item.

  When the processing circuit 4 determines that the measurement of the quality control sample is not performed, the display 5 displays the second warning information on the measurement result of the measurement item. At this time, the display 5 displays the second warning information based on the control signal from the processing circuit 4. The second warning information only needs to be information that tells the operator that the measurement of the quality control sample has not been performed. As long as the information indicates this content, the specific information format of the second warning information may be appropriately designed such as text information or image information. The operator can grasp from the second warning information that the measurement of the quality control sample is not performed.

  When determining that the measurement of the quality control sample has been performed, the processing circuit 4 further determines whether the measurement result of the quality control sample is normal. For example, the processing circuit 4 collates the measurement result of the quality control sample (concentration or activity obtained by collation with the calibration curve) with a known value (known concentration or activity) of the quality control sample, and It is determined whether or not the error is within an allowable range. This allowable range is set in advance for each measurement item by the operator, for example. When this error is within the allowable range, the processing circuit 4 determines that the measurement result of the quality control sample is normal. When the processing circuit 4 determines that the measurement result is normal, the processing circuit 4 determines that the measurement result of the test sample is valid. Determining that the sample is effective corresponds to determining that the concentration and activity of the test substance in the test sample have been measured normally in the automatic analyzer 1 of the embodiment. The processing circuit 4 attaches additional information indicating that the measurement result of the test sample is effective.

  When the error is not within the allowable range, the processing circuit 4 determines that the measurement result of the quality control sample is not normal. When the processing circuit 4 determines that the measurement result is not normal, the processing circuit 4 corrects the calibration curve of the measurement item. An example of this correction processing is blank correction. General processing contents may be applied to the processing contents of the blank correction. Next, the processing circuit 4 performs quality control measurement on the calibration curve after the correction processing. At this time, the processing circuit 4 collates the measurement result obtained by collation with the calibration curve after the correction process and a known value of the quality control sample, and determines whether or not these errors are within an allowable range. Judge. When the error is within the allowable range, the processing circuit 4 determines that the measurement result of the quality control sample on the calibration curve after the correction processing is normal. Then, the processing circuit 4 recalculates the measurement result of the test sample based on the calibration curve after the correction processing. For example, the processing circuit 4 compares the measurement result of the test sample with the calibration curve after the correction processing, and measures the concentration and activity of the test substance in the test sample.

  The processing circuit 4 collates the measurement result obtained by collation with the calibration curve after the correction processing and the known value of the quality control sample, and when these errors are not within an allowable range, the measurement of the test sample is performed. Invalidate the result. For example, the processing circuit 4 attaches additional information indicating invalidity to the measurement result of the test sample. Further, the processing circuit 4 outputs to the display 5 a control signal indicating that the measurement result of the test sample is invalid. The display 5 displays information indicating that the measurement result is invalid. The operator can know that the measurement result of the test sample is invalid.

  In this case, the processing circuit 4 controls the analysis module 2, performs measurement using the calibration sample, and recreates a calibration curve. General processing may be applied to the calibration curve re-creation processing. At this time, similarly to the example of FIG. 3, the display 5 may display a rack layout related to the installation position of the calibration sample. Then, the automatic analyzer 1 re-measures the test sample based on the re-created calibration curve.

  4A and 4B are flowcharts illustrating the operation of the automatic analyzer 1 according to the embodiment.

  Step S101: The operator inputs a measurement instruction indicating a measurement item to the processing circuit 4 via the input circuit 6. The processing circuit 4 receives this measurement instruction.

  Step S102: The processing circuit 4 calculates a measurement blank period, which is a period from the previous measurement, for the measurement item for which the measurement instruction has been received. At this time, the processing circuit 4 calculates the measurement blank period based on the latest measurement time and the measurement instruction time that is the time when the measurement instruction was received.

  Step S103: The processing circuit 4 compares the predetermined period corresponding to the measurement item for which the measurement instruction has been received with the calculated measurement blank period. Accordingly, the processing circuit 4 determines whether the measurement blank period of the measurement item for which the measurement instruction has been received is equal to or longer than a predetermined period. When it is determined that the measurement blank period of the measurement item for which the measurement instruction has been received is not longer than the predetermined period (Step S103; No), the operation of the automatic analyzer 1 of the embodiment proceeds to Step S104. When it is determined that the measurement blank period of the measurement item for which the measurement instruction has been received is equal to or longer than the predetermined period (step S103; Yes), a control signal indicating this determination is output to the display 5 together with the measurement item. The operation of the automatic analyzer 1 according to the embodiment proceeds to step S105.

  Step S104: The analysis module 2 measures the concentration and activity of the test substance (measurement item) in the test sample. The processing circuit 4 may attach additional information indicating that the measurement result of the test sample is effective.

  Step S105: The display 5 displays, based on the control signal from the processing circuit 4, quality control recommendation information for recommending measurement of the quality control sample related to the measurement item.

  Step S106: When the operator performs an operation input to perform the quality control measurement (Step S106; Yes), the operation of the automatic analyzer 1 of the embodiment proceeds to Step S107. When the operator performs an operation input indicating that the quality control measurement is not performed (Step S106; No), the operation of the automatic analyzer 1 of the embodiment proceeds to Step S104.

  Step S107: The processing circuit 4 determines whether or not the injection of the quality control sample has been performed. When it is determined that the quality control sample has not been loaded (Step S107; No), a control signal indicating this determination is output to the display 5 together with the measurement item. The operation of the automatic analyzer 1 according to the embodiment proceeds to step S108. When it is determined that the introduction of the quality control sample has been performed (Step S107; Yes), the operation of the automatic analyzer 1 of the embodiment proceeds to Step S109.

  Step S108: The display 5 displays the first warning information based on the control signal from the processing circuit 4. The first warning information may be any information as long as it informs the operator that the quality control sample has not been loaded.

  Step S109: The processing circuit 4 determines whether or not the measurement of the quality control sample has been performed. When it is determined that the measurement of the quality control sample is not performed (Step S109; No), a control signal indicating a control signal indicating this determination is output to the display 5 together with the measurement item. The operation of the automatic analyzer 1 according to the embodiment proceeds to step S110. When it is determined that the measurement of the quality control sample has been performed (Step S109; Yes), the operation of the automatic analyzer 1 of the embodiment proceeds to Step S111.

  Step S110: The display 5 displays the second warning information based on the control signal from the processing circuit 4. The second warning information only needs to be information that tells the operator that the measurement of the quality control sample has not been performed.

  Step S111: The processing circuit 4 determines whether or not the measurement result of the quality control sample is normal. When it is determined that the measurement result of the quality control sample is normal (Step S111; Yes), the operation of the automatic analyzer 1 of the embodiment proceeds to Step S112. When it is determined that the measurement result of the quality control sample is not normal (Step S111; No), the operation of the automatic analyzer 1 of the embodiment proceeds to Step S113.

  Step S112: The processing circuit 4 attaches supplementary information indicating that the measurement result of the test sample is valid. During the process from step S107 to step S112, the analysis module 2 measures the concentration and the activity of the test substance (measurement item) in the test sample. The value obtained by this measurement is stored in the storage circuit 3 in a state where the determination of validity / invalidity is suspended (a state in which neither additional information indicating validity nor additional information indicating invalidity is attached). Have been.

  Step S113: The processing circuit 4 performs a correction process of the calibration curve of the measurement item. An example of this correction processing is blank correction.

  Step S114: The processing circuit 4 performs quality control measurement on the calibration curve after the correction processing.

  Step S115: The processing circuit 4 determines whether or not the measurement result of the quality control sample on the calibration curve after the correction processing is normal. When it is determined that the measurement result of the quality control sample on the calibration curve after the correction processing is normal (step S115; Yes), the operation of the automatic analyzer 1 of the embodiment proceeds to step S116. When it is determined that the measurement result of the quality control sample on the calibration curve after the correction processing is not normal (Step S115; No), the operation of the automatic analyzer 1 of the embodiment proceeds to Step S117.

  Step S116: The processing circuit 4 recalculates the measurement result of the test sample based on the calibration curve after the correction processing.

  Step S117: Invalidate the measurement result of the test sample. For example, the processing circuit 4 attaches additional information indicating invalidity to the measurement result of the test sample.

  Step S118: The processing circuit 4 controls the analysis module 2, performs measurement using the calibration sample, and re-creates a calibration curve.

  According to the automatic analyzer 1 of the embodiment described above, it is possible to easily manage the accuracy of a measurement item having a long period from the last measurement. In addition, after determining that the measurement result of the quality control sample is normal, the measurement result of the already measured test sample is validated. The number of cases discharged can be reduced. In addition, by displaying information indicating a rack set layout for quality control measurement, it is possible to save the trouble of properly using the rack 27 dedicated to the test sample and the rack 27 dedicated to the quality control sample. Further, quality control measurement is performed on a measurement item having a short period from the previous measurement, so that it is possible to prevent the quality control sample from being consumed in large quantities.

  Although an embodiment of the present invention has been described, this embodiment has been presented by way of example only, and is not intended to limit the scope of the invention. This embodiment can be implemented in other various forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. This embodiment and its modifications are included in the scope and gist of the invention, and are also included in the invention described in the claims and equivalents thereof.

Reference Signs List 1 automatic analyzer 2 analysis module 3 storage circuit 4 processing circuit 5 display 6 input circuit 21a first reagent bottle 21b second reagent bottle 22a first reagent rack 22b second reagent rack 23a first reagent storage 23b second reagent storage 24 reaction Tube 25 Reaction disk 26 Sample container 27 Rack 28a First dispensing arm 28b Second dispensing arm 29 Sampling arm 30 Stirring unit 31 Photometry unit 32 Washing unit 41 Calculation function 42 Judgment function

Claims (7)

A storage unit that stores measurement history information indicating a measurement history for each measurement item,
Based on the measurement history information, a calculation unit that calculates a measurement blank period that is an elapsed period from the previous measurement for the measurement item that received the measurement instruction,
Based on the measurement blank period and a predetermined period, a determination unit that determines whether the measurement blank period of the measurement item that has received the measurement instruction is equal to or longer than the predetermined period,
When the determination unit determines that the measurement blank period of the measurement item that has received the measurement instruction is equal to or longer than the predetermined period, the quality control recommendation information that recommends measurement of the quality control sample related to the measurement item is displayed. Display unit to be
An automatic analyzer having a. The storage unit stores, as measurement history information, the latest measurement time as the last measurement time for each measurement item,
The automatic analyzer according to claim 1, wherein the calculation unit calculates the measurement blanking period based on the latest measurement time and a measurement instruction time that is a time when the measurement instruction is received. .   The automatic analyzer according to claim 1, wherein the display unit displays information recommending the introduction of the quality control sample as the quality control recommended information. The determination unit, when it is determined that the measurement blank period is equal to or longer than the predetermined period, further determines whether or not the input of the quality control sample,
The display unit displays first warning information relating to a measurement result of the measurement item when the determination unit determines that the quality control sample has not been inserted. 4. The automatic analyzer according to 3. The determining unit, when it is determined that the measurement blank period is equal to or longer than the predetermined period, further determines whether the measurement of the quality control sample was performed,
The display unit, when the determination unit determines that the measurement of the quality control sample is not performed, displays the second warning information related to the measurement result of the measurement item. 3. The automatic analyzer according to 1 or 2.   When the determination unit determines that the measurement of the quality control sample is performed, further, determines whether the measurement result of the quality control sample is normal, when it is determined that the measurement result is normal 6. The automatic analyzer according to claim 5, wherein the measurement result of the test sample is determined to be valid. The determination unit, when it is determined that the measurement of the quality control sample was performed, further, determines whether the measurement result of the quality control sample is normal,
When the determination unit determines that the measurement result is not normal, the calculation unit corrects the calibration curve of the measurement item for which the measurement instruction has been received, and calculates the calibration curve based on the calibration curve after the correction process. The automatic analyzer according to claim 5, wherein the calculation result of the test sample is recalculated.

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