JP6592346B2 - External composition for skin containing tranexamic acid - Google Patents

Description

The present invention relates to a composition for external use on skin containing a whitening component having a high ultraviolet protection function.

There are many women who use whitening cosmetics and sunscreen cosmetics in order to realize skin without freckles and freckles. Spots and freckles are caused by an increase in the amount of melanin pigment in the skin caused by the stimulation of ultraviolet rays, which is abnormally deposited in the skin. In order to prevent spots and freckles due to sunburn, it is effective to use a sunscreen cosmetic blended with an ultraviolet scattering agent such as titanium oxide or an ultraviolet absorber. Moreover, the sunscreen effect improves remarkably by using a ultraviolet-ray scattering agent and a ultraviolet absorber together. Furthermore, it is effective to use a cosmetic containing a whitening component such as a vitamin C derivative or a resorcin derivative, so-called whitening cosmetic, for a stain or the like that has already been formed (for example, Patent Document 1). Therefore, it can be said that the combination of sunscreen cosmetics and whitening cosmetics is optimal for realizing a skin free from spots and freckles.

On the other hand, an external composition for skin containing titanium oxide as an ultraviolet scattering agent and tranexamic acid as a whitening component, that is, an external composition for skin having the effects of sunscreen cosmetics and whitening cosmetics is already known. (Patent Document 2). An external composition for skin containing a UV absorber and tranexamic acid is already known (Patent Document 3). However, ultraviolet absorbers have problems in usability such as stickiness due to their chemical structure and a large amount of blending (Patent Document 4). Moreover, the feeling of use which tranexamic acid has also has a squeak feeling etc., and this also becomes the same subject. Therefore, there has been a demand for a composition for external use on the skin, which contains a UV absorber and tranexamic acid and has a good sunscreen effect and a high sunscreen effect.

Japanese Patent Laid-Open No. 2-49715 JP 2002-128646 A JP 2014-1111584 A JP 2010-132647 A

An object of the present invention is to obtain a composition for external use on the skin, which contains an ultraviolet absorber and tranexamic acid and has a good sunscreen effect and a high sunscreen effect.

In view of such a situation, the present inventors used various raw materials used in the cosmetics field in combination, and as a result of earnest research aimed at solving the above problems, the following preparations were obtained. The present inventors have found that a composition for external use on skin containing a UV absorber and tranexamic acid and having a good sunscreen effect can be realized, and the present invention has been completed. That is, the present invention is as follows.

<1> A composition for external use of skin, comprising (a) tranexamic acid or a salt thereof and (b) methylenebis-benzotriazolyltetramethylbutylphenol.
<2> The external composition for skin according to <1>, wherein the external composition for skin is a foundation.
<3> The external composition for skin according to <2>, wherein the foundation is a powder solid dosage form.
<4> The external composition for skin according to any one of <1> to <3>, wherein (b) methylenebis-benzotriazolyltetramethylbutylphenol is coated on the surface of the powder. object.
<5> The external composition for skin according to <4>, wherein the powder is talc.
<6> The external composition for skin according to any one of <1> to <5>, wherein the external composition for skin contains 40% by mass or more of a plate-like powder.

ADVANTAGE OF THE INVENTION According to this invention, the composition for external use of skin with a high sunscreen effect with the favorable usability containing a ultraviolet absorber and tranexamic acid can be provided.

<1> Tranexamic acid or salt thereof of the present invention The tranexamic acid or salt thereof of the present invention may be any one that is generally used in cosmetics and the like. As content, 0.01-5 mass% is preferable with respect to the skin external composition whole quantity, and 1-2 mass% is more preferable.

<2> Methylene bis-benzotriazolyl tetramethylbutylphenol of the present invention The methylene bis-benzotriazolyl tetramethylbutylphenol of the present invention may be any one generally used in cosmetics and the like. Methylene bis-benzotriazolyl tetramethylbutylphenol has a low solubility in a cosmetic oil and is insoluble in water. Therefore, for example, it is preferably blended in a form dispersed in an aqueous phase. At that time, for example, commercially available TINOSORB M (aqueous dispersion of methylenebis-benzotriazolyl tetramethylbutylphenol, manufactured by BASF) can be used as it is. It is also preferable to coat and blend the powder surface. At that time, for example, commercially available MBBT talc DM (powder coated with methylenebis-benzotriazolyltetramethylbutylphenol and then surface-treated with dimethicone, manufactured by Dainippon Kasei Co., Ltd.) can be used as it is. it can. The content of methylene bis-benzotriazolyl tetramethylbutylphenol is preferably 0.1 to 5% by mass and more preferably 0.4 to 2.5% by mass with respect to the total amount of the composition for external use on the skin.

<3> Plate-shaped powder of the present invention The plate-shaped powder of the present invention may be any powder that is generally used in cosmetics and the like. You may coat | cover with silicone, titanium, a silica, a ultraviolet absorber, a fatty acid, etc. Preferred examples of the plate-like powder include talc, sericite, mica, titanium mica, and titanium sericite. Talc is preferred. As content of plate-shaped powder, 60 mass% or more is preferable with respect to the skin external composition whole quantity. Moreover, as content of talc, 40 mass% or more is preferable with respect to the skin external composition whole quantity.

<4> External composition for skin of the present invention The external composition for skin of the present invention is not particularly limited as long as it is externally administered to the skin. For example, cosmetics including quasi-drugs, and external preparations for skin Goods etc. can be illustrated suitably. Of these, cosmetics are particularly preferred. Moreover, any of conventionally known emulsion dosage forms, cream dosage forms, powder-containing dosage forms, and oil-based dosage forms can be used. Among these, a powder solid dosage form is preferable. As the cosmetic, any of basic cosmetics, hair cosmetics, and makeup cosmetics can be applied, but it is particularly preferable to apply them to makeup cosmetics, especially foundations.

The external composition for skin of this invention can contain the arbitrary components normally used by cosmetics other than said component. Optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, palm oil, palm oil, liquid lanolin, hardened palm oil, hardened oil Oil, wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, microcrystallin, oil, wax, liquid oil, waxy wax, liquid paraffin, squalane, pristine Hydrocarbons such as wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol , Behenyl alcohol, octyldodecanol, higher alcohols such as myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpolysiloxa , Chain polysiloxanes such as diphenylpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine Oil agents such as silicone oil such as modified polysiloxane such as modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkyl sulfate triethanolamine ether, chloride Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinini) Umhydroxide-1-carboxyethyloxy disodium salt), betaine surfactants (alkyl betaines, amide betaines, sulfobetaines, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan mono) Stearates, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters ( POE sorbitan monooleate, polysoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl ether) ), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Sho Nonionic surfactants such as sugar fatty acid esters and alkyl glucosides, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol Polyol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol and other polyhydric alcohols, pyrrolidone carvone Moisturizing ingredients such as sodium acid, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin Sulfuric acid, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydro Xiethyl guar gum, carboxymethyl guar gum, dextran, keratosulfate, locust bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, sodium polyacrylate, polyethylene Thickeners such as glycol and bentonite, surface may be treated, powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate Surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, titanium mica, fish Phosphorous foil, bismuth oxychloride, etc. Red, No. 202, Red 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201 No., Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, and the like, polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer , Organic powders such as cellulose powder, urethane powder, silk powder, etc., powder coated with a bio-component-like polymer such as a copolymer of methacryloyloxyalkylphosphorylcholine and alkyl methacrylate, ethanol, Lower alcohols such as isopropanol, vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 Ripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B such as vitamin B12, vitamin B15 or derivatives thereof, vitamin E such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D Vitamins such as vitamin H, pantothenic acid, and pantethine can be preferably exemplified, and can be blended as optional components.

EXAMPLES Hereinafter, although this invention is demonstrated further in detail based on an Example, this invention is not limited to a following example.

<Manufacture example 1> Preparation of the composition for external use of skin of this invention According to prescription shown in Table 1 Example 1, the composition for external use of skin of this invention (foundation of a powder solid dosage form) was prepared. That is, while mixing the A component with a juicer, the B component and the C component were sequentially added and stirred uniformly. Thereafter, it was filled in an aluminum container having a length of 25 mm, a width of 30 mm, and a depth of 3 mm, and then pressed with a pressure of 30 kg / cm ² to obtain a composition for external use on the skin. In addition, referring to Example 1, Examples 2 to 8 and Comparative Examples 1 to 3 were similarly prepared. Shown in Tables 1 and 2.

<Manufacture example 2> Preparation of the composition for external use of skin of this invention According to the prescription shown in Table 3, the composition for external use of skin of this invention (foundation of an emulsifier form) was prepared (Example 9). That is, while mixing the A component with a homomixer while heating the A component, the B component and the C component were sequentially added and uniformly emulsified to obtain an external composition for skin.

<Test Example 1> UV protection function evaluation (sunscreen effect)
The compositions for external use shown in Tables 1 and 2 were applied to the backs of 20 panelists, and the UV protection index (SPF) was measured according to the Japan Cosmetic Industry Association Act. The results are shown in Tables 1 and 2.

<Test Example 2> Usability evaluation Five special panels used the compositions for external use on skin shown in Tables 1 and 2, and evaluated stickiness and squeaky feeling. The evaluation criteria are shown below. The results are shown in Tables 1 and 2.

<Stickiness>
1: There is no stickiness and there is no problem in usability.
2: There is not much stickiness and there is no problem in usability.
3: A feeling of stickiness is slightly felt, but the problem is small in terms of usability.
4: There is a sticky feeling, which is a problem in terms of usability.
<Squeaking>
1: There is no squeaky feeling and there is no problem in usability.
2: There is not much squeaky feeling and there is no problem in usability.
3: A slight squeak is felt, but the problem is small as usability.
4: There is a squeaky feeling, which is a problem as usability.

From the results shown in Tables 1 and 2, it can be seen that the present invention is a composition for external use for skin having a good sunscreen effect and containing an ultraviolet absorber and tranexamic acid.

INDUSTRIAL APPLICABILITY The present invention can be used for a composition for external skin containing a whitening component having a high UV protection function.

Claims (4)

A composition for external use on skin, comprising (a) tranexamic acid or a salt thereof and (b) methylenebis-benzotriazolyltetramethylbutylphenol ,
An external composition for skin , which is a powder solid dosage form foundation . A composition for external use on skin, comprising (a) tranexamic acid or a salt thereof and (b) methylenebis-benzotriazolyltetramethylbutylphenol ,
A composition for external use of skin, comprising 60% by mass or more of a plate-like powder in the composition for external use of skin. The external composition for skin according to claim 1 or 2 , wherein the surface of the powder is coated with (b) methylenebis-benzotriazolyl tetramethylbutylphenol. The external composition for skin according to claim 3, wherein the powder is talc.