JP6426902B2 - Carotenoid-Containing Composition, Carotenoid Deterioration Inhibitor, and Carotenoid Deterioration Suppression Method - Google Patents

Description

  The present invention relates to a composition characterized by containing carotenoid and isopropanol, and more particularly, to a composition having enhanced stability of carotenoid with isopropanol, and a deterioration inhibitor of carotenoid and a method of suppressing deterioration of carotenoid.

  As polyphenols such as catechin and carotenoids such as astaxanthin, those having useful effects on the skin such as antiaging, prevention and improvement of stains and the like are known. Carotenoids are naturally occurring yellow to red terpenoid pigments that can be found in plants, algae and bacteria. Astaxanthin (including astaxanthin and its ester etc.), which is a kind of carotenoid, is widely distributed in the animal and plant kingdom in the natural world, and is mainly used as a color frying agent for cultured fish and poultry. Also, it is known that astaccitinsan has functions such as an antioxidant effect, an anti-inflammatory effect (patent document 1, patent document 2), a skin anti-aging effect (patent document 3), and the like. Therefore, it has been studied and implemented to add astakitinsan to raw materials of foods, cosmetics, pharmaceuticals and processed products thereof.

  On the other hand, carotenoids such as astaxanthin are structurally unstable, and are known to accelerate decomposition by heat, light, oxidation and the like, and it is difficult to stably blend them into preparations. Therefore, in addition to the combination with ascorbic acid and the inclusion with a hard capsule, etc. have been devised (see Patent Document 4), a method of combining a specific oil-soluble plant extract with an alcohol and a nut polyphenol and a chelating agent (See Patent Document 5) or a method of adding an organic acid to a carotenoid-containing composition (see Patent document 6), iron ion, iron chelating agent, dibromoylene glycol, combined use with a water-soluble antioxidant (see Patent Document 7) There is disclosed a method for stabilizing carotenoids such as astaxanthin, etc., in combination with red wine extract and collagen peptide (see Patent Document 8).

  However, in any of these methods, if the stabilizing agent is expensive, the stabilizing effect is not sufficient, or if the stabilizing agent is a water-soluble component, dispersion in an oily component that dissolves carotenoids such as astaxanthin Problems such as being unable to exert sufficient effects. Furthermore, it was not satisfactory from the viewpoint of enhancing the stability of carotenoids such as astaxanthin which are known to have useful effects and maintaining the effects over a long period of time.

JP-A-2-49091 JP-A-9-143063 JP-A-5-155736 Unexamined-Japanese-Patent No. 1-215263 Unexamined-Japanese-Patent No. 2010-105988 Japanese Patent Application Laid-Open No. 6-264055 JP, 2012-31067, A JP, 2009-159929, A

  The problem to be solved by the present invention is to improve the stability of carotenoids such as astaxanthin which are known to be useful for preventing aging and the like, and a stabilizing method and a stabilizing agent for maintaining the effect over a long period of time. It is to provide.

  In view of such circumstances, the inventor of the present invention has intensively studied to solve the above problems, and by combining a carotenoid such as astaxanthin with isopropanol, it exhibits a remarkable effect in preventing or stabilizing fading due to light of carotenoid such as astaxanthin. It is possible to dramatically enhance the anti-aging effect and the like possessed by carotenoids such as astaxanthin, and to complete the present invention.

That is, the present invention provides the following components (a) and (b):
It is intended to provide a composition comprising (a) a carotenoid (b) isopropanol.

  It is an object of the present invention to provide a composition characterized in that the component (a) is astaxanthin.

  Furthermore, the composition is characterized in that it contains a triester of a fatty acid having 8 to 12 carbon atoms and glycerin as the component (c).

  It is an object of the present invention to provide a composition characterized in that the content mass ratio (b) / (a) of the component (a) to the component (b) is 100 to 5,000.

  Furthermore, the composition is characterized in that the component (c) is a triester of caprylic acid and / or capric acid with glycerin.

  Further, the present invention provides a composition characterized by containing vitamin E as the component (d).

  It provides cosmetic or skin external preparation.

It is intended to provide a carotenoid deterioration inhibitor containing isopropanol as an active ingredient.

  It is an object of the present invention to provide a method for inhibiting the deterioration of carotenoids, which comprises adding isopropanol to a composition containing carotenoids.

  The composition, the cosmetic, the external preparation for skin, the agent for suppressing deterioration, and the method for suppressing deterioration of the present invention can effectively use carotenoids such as astaxanthins by improving the stability of carotenoids such as astaxanthins.

  The carotenoid of component (a) in the composition of the present invention includes any of plants, algae and bacteria. Further, the present invention is not limited to naturally occurring ones, and any one obtained according to a conventional method is included in the carotenoid in the present invention.

  Carotenoids include hydrocarbons (carotenes) and their oxidized alcohol derivatives (xanthophylls) and their esters. In the present invention, unless otherwise specified, these compounds are collectively referred to as "carotenoids". Examples of carotenoids include actinio erythrol, astaxanthin, bixin, canthaxanthin, capsanthin, capsorbin, β-8'-apo-carotenal (apocarotenal), β-12'-apo-carotenal, α-carotene, β-carotene "Carotene" (mixture of α- and β-carotenes), γ-carotene, δ-carotene, β-cryptoxanthin, equinenone, palm oil carotene, lutein, lycopene, violerythrin, zeaxanthin, fucoxanthin and among them hydroxyl Or esters of those containing carboxyl can be mentioned.

  The carotenoid used in the present invention is preferably oily at normal temperature. Particularly preferable examples are astaxanthins which have an antioxidant effect, an anti-inflammatory effect, an anti-skin anti-aging effect, a whitening effect and the like and are known as colorants in the yellow to red range.

Astaxanthin is a red pigment having an absorption maximum at 476 nm (ethanol) and 468 nm (hexane) and is classified into xanthophylls, and its chemical structure is 3,3'-dihydroxy-β, β-carotene-4,4'-dione ( C ₄₀ H ₅₂ 0 ₄ , molecular weight 596.82). In the present invention, unless otherwise specified, the above astaxanthins and derivatives such as astaxanthin esters are referred to as "astaxanthins". Since astaxanthin is more unstable than derivatives such as astaxanthin ester, higher effects can be expected when using astaxanthin in the present invention.

  Astaxanthins to be used in the present invention may be extracted from natural products such as krill, salmon, trout, forage grass, red yeast, hematococcus algae and synthetic products, but it is possible to use astaxanthins extracted from hematococcus algae. Ones (hereinafter also referred to as hematococcus alga extract) are particularly preferable in terms of quality and productivity. The extraction solvent for obtaining astaxanthin from a natural product may be an aqueous solvent or an organic solvent. As the organic solvent, methanol, ethanol, isopropanol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, ethyl acetate, ether, hexane and the like can be used. In addition, carbon dioxide in a supercritical state can also be used. These solvents may be used alone or in combination of two or more.

  Specific examples of the source of the Haematococcus alga extract that can be used in the present invention include Haematococcus pluvialis, Haematococcus lacustris, Haematococcus capensis, Haematococcus. Haematococcus droebakensis, Haematococcus zimbabensis, etc. are mentioned. In addition, Hematococcus alga extract that is widely marketed can be used, for example, ASTATS-S, -5O, -10O, etc., manufactured by Takeda Paper Co., Ltd., astalel oil 50F, manufactured by Fuji Chemical Industries, Ltd., 5F and the like, astaxanthin-5C and 20C manufactured by Oryza Yuka Co., Ltd., astaxanthin 5% oil manufactured by Bioactives Japan, Astabio (registered trademark) AR1 and AR5 manufactured by Biogenic, and the like. In addition, as the origin of krill, Astax-S manufactured by Marine Daioh Co., Ltd. and the like can be mentioned.

  The content of the component (a) in the composition of the present invention is not particularly limited, but preferably 0.00001 to 5% by mass (hereinafter simply referred to as “%”), more preferably 0.0001 to 1% It is. When the extract is used, the extract concentration and the like are not limited at all as long as the amount of the solute falls within the above range.

  Component (b) in the composition of the present invention is isopropanol, which is a component that inhibits the deterioration of carotenoids. The origin of the component (b) is not particularly limited, and may be chemically synthesized or may be extracted from natural products.

As commercial products of the component (b), IPA (manufactured by Shin Nippon Petrochemical Co., Ltd.), Tokso IPA (manufactured by Tokuyama Corp.) and isopropyl alcohol (manufactured by Mitsui Chemical Co., Ltd.) are available. The species or more can be appropriately selected and used.
Moreover, the raw material containing isopropanol may be sufficient, for example, DN silicone emulsion 100000 (made by Dainippon Chemical Co., Ltd.), DN-R CONC VP (made by Dainippon Chemical Co., Ltd.), KP-541 (made by Shin-Etsu Chemical Co., Ltd.), NIKKOL CA-2150 (manufactured by Nikko Chemicals), NIKKOL CA-2350 (manufactured by Nikko Chemicals), NIKKOL CA-2465 (manufactured by Nikko Chemicals), NIKKOL CA-3475V (manufactured by Nikko Chemicals), RonaCare Troxerutin (Merck KGaA) Product), cation 2ABT (manufactured by NOF Corporation), cation AB-600 (manufactured by NOF Corporation), cation AB-800S (manufactured by NOF Corporation), cation PB-40R (manufactured by NOF Corporation), cation VB-M flakes (Made by NOF Corporation), LUVISCOAL VA 37 I (BASF JA) Made by RIN CO., LTD., Rubiscol VA 55 I (made by BASF Japan Ltd.), BENTONE GEL 389 K (made by DURLIN FRANCE), Catinal DC-80 (made by Toho Chemical Industry Co., Ltd.), Catinal STC-80 (made by Toho Chemical Industry Co., Ltd.) KDMP-J (manufactured by Clariant Japan), GENAMIN STAC (manufactured by Clariant Japan), JR 400 (manufactured by Dow Chemical), ARCARD 2HP-75 (manufactured by Lion Akzo), VARISOFT BT 85 PELLETS (EVONIK GOLDSCHMIDT) GMBH) can be obtained, and one or two or more can be appropriately selected and used as needed.

  The content of the component (b) in the composition of the present invention is not particularly limited, and may differ depending on the external preparation, the dosage form of the cosmetic, the purpose of use, etc. It is preferably 70%, more preferably 0.05% to 50%, and still more preferably 0.01% to 10%. If it is in this range, the effect of stabilization of component (a) can be exhibited.

  Moreover, content mass ratio (b) / (a) of a component (a) and a component (b) is although it does not specifically limit, It is excellent in the stabilization effect of a component (a) as it is 10-7000, and 100-5000. Since it will be further excellent in the effect of stabilization of a component (a) as it is, it is preferable.

  The composition of the present invention preferably further contains a triester of a fatty acid having 8 to 12 carbon atoms and glycerin as the component (c), and the stability of the component (a) by containing the component (c) Be excellent. The origin of the component (c) is not particularly limited, and may be chemically synthesized or may be extracted from a natural product.

Although the component (c) is not particularly limited, specifically, tri (caprylic · capric acid) glyceryl, triethylhexanoin etc. which are triesters of caprylic acid and / or capric acid with glycerine And more preferably glyceryl tri (caprylic · capric). These carbon numbers may be one or a mixture of two or more. In addition, tri (caprylic · capric acid) glyceryl is an oil agent having a triester structure of glycerin and caprylic acid or capric acid, and triethylhexanoin is a triester structure of glycerin and 2-ethylhexanoic acid It is an oil that has As commercially available products, tri (caprylic acid / capric acid) glyceryl (Triester F-810J: manufactured by Nippon Surfactant Industries Co., Ltd.), triethylhexanoin (T.IO: manufactured by Nisshin Oillio Group, Inc.), etc. are available. is there

  The content of the component (c) in the composition of the present invention is not particularly limited, and may vary depending on the external preparation, the dosage form of the cosmetic, the purpose of use, etc. % Is preferable, and more preferably 5 to 25%. If it is in this range, the effect of stabilization of component (a) can be exhibited.

  The composition of the present invention preferably further contains vitamin E as component (d). By containing the component (d), the stability of the component (a) becomes excellent. Vitamin E of component (d) of the present invention is a kind of fat-soluble vitamin, and depending on the position of methyl group, DL-α-tocopherol, DL-β-tocopherol, DL-γ-tocopherol, DL-δ-tocopherol, There are eight types of D-α-tocopherol, D-β-tocopherol, D-γ-tocopherol and D-δ-tocopherol. Vitamin E used for cosmetics etc. is a mixture of these in many cases.

  The content of the component (d) in the present invention is not particularly limited, and varies depending on the external preparation, the dosage form of the cosmetic, the purpose of use, etc. It is preferably 0%, more preferably 0.001 to 1.0%. If it is in this range, the effect of stabilization of component (a) can be exhibited.

  In the composition of the present invention, in addition to the above components, cosmetic, skin external preparation, food, ink, detergent, softener for clothes, fragrance, in addition to the above components as needed. Ingredients used in preparations such as deodorant and textiles, that is, water (refined water, hot spring water, deep layer water etc.), oil agent, surfactant, metal soap, gelling agent, powder, alcohol, water soluble Polymers, film-forming agents, resins, UV protection agents, inclusion compounds, antibacterial agents, fragrances, deodorants, salts, pH adjusters, refreshing agents, extracts derived from animals and microorganisms, plant extracts, blood circulation promoters, An astringent agent, anti-seborrhoeic agent, whitening agent, anti-inflammatory agent, active oxygen scavenger, cell activator, moisturizer, chelating agent, keratolytic agent, enzyme, hormones, vitamins and the like can be added.

  The method for producing the composition of the present invention is not particularly limited, and is prepared by a conventional method. For example, the method prepared by adding the said component (a) and (b) and also the said arbitrary component as needed, and mixing this is mentioned.

  The composition of the present invention can be carried out in various forms such as liquid, gel, cream, solid, mousse, etc. You may use it. In addition, the dosage form of the product of the present invention is not particularly limited, such as solubilization type, oil-in-water type, water-in-oil type, oil-based type, water-in-oil-in-water type, oil-in-oil-in-oil type, multilayer type and the like.

  There is no particular limitation on the use of the composition of the present invention, and it is used as a composition for various uses such as cosmetics, external preparations for skin, foods, inks, detergents, softeners for clothes, fragrances, deodorants, textiles and the like. be able to. Carotenoids are characterized by being excellent in antioxidant effect, anti-inflammatory effect, and skin anti-aging effect, and from that point of view, it is preferable to use as a cosmetic or a skin external preparation.

  Examples of the food (including animal feed) of the present invention include frozen foods, powdered foods, sheet-like foods, bottled foods, canned foods, retort foods, capsule-like foods, tablet-like foods, etc. It may be any form such as a natural liquid food compounded with saccharides, fats, trace elements, vitamins, emulsifiers, flavors, etc., a semi-digestive nutrition food and a component nutrition food, a processed form such as a drink agent and the like.

  Examples of the cosmetic of the present invention are not particularly limited. For example, skin care cosmetics such as emulsions, creams, lotions, cosmetic solutions, packs, foundations, blushers, lipsticks, eye colors, mascaras, eye liners, manicures, etc. The cosmetic may be in any form such as makeup cosmetics, hair nourishing agents, hair tonics, shampoos, rinses, hair cosmetics such as hair wax, and cleansing agents such as face cleansers.

  Examples of the external preparation for skin of the present invention are not particularly limited, and may be, for example, any form such as external preparation gel, cream, ointment, solution, liniment, happ or the like.

Moreover, this invention is an agent which suppresses deterioration of a carotenoid by setting it as the composition containing a carotenoid and isopropanol.

Further, the present invention is a method for suppressing the deterioration of carotenoids by using a composition containing carotenoids and isopropanol.

  Hereinafter, the present invention will be more specifically described by way of examples, but the scope of the present invention is not limited to these.

Example 1
<Test for preventing deterioration of astaxanthin>

Astaxanthin has a characteristic light absorption at a wavelength of 470 nm, and when degradation of astaxanthin occurs, the remaining rate of astaxanthin was calculated according to the following procedure using the property that light absorption at a wavelength of 470 nm decreases. . The results are shown in Tables 1 and 2.
As a sample, astaxanthin 5% solution (ASTAX-S (made by Marin Daio Co., Ltd.)) 0.01% (astaxanthin 0.0005%), ethanol containing 25%, isopropanol (IPA: made by Shin Nippon Petrochemical Co., Ltd.) 70.0% (Example 1), 50.0% (Example 2), 10.0% (Example 3), 1.00% (Example 4), 0.100% (Example 5) A solution containing the concentration was prepared. The concentration of each solution was adjusted using tri (caprylic capric acid) glyceryl (Triester F-810J: manufactured by Nippon Surfactant Industries, Ltd.) as a correction raw material. Each sample solution was dispensed into a 96-well plate and irradiated with ultraviolet light (intensity: UVA: 1.04 J / cm 2, UVB: 2.45 J / cm 2).

The astaxanthin residual rate was calculated using the following equation (1) by measuring the absorbance at 470 nm of each sample solution. Here, the astaxanthin-containing system refers to one prepared by diluting astaxanthin (Hematococcus alga) 0.1% to 0.1 to 50% of component (b) and adding ethanol to 100%, The astaxanthin-free system refers to one prepared by adding 0.1 to 50% of the component (b) to 100% ethanol.

Astaxanthin residual rate (%) = ((A−B) / (C−D)) × 100 (1)

A = Absorbance of ultraviolet-irradiated astaxanthin-containing system B = Absorbance of ultraviolet-irradiated astaxanthin-free system C = Absorbance of ultraviolet-unirradiated astaxanthin-containing system D = Absorbance of ultraviolet-unirradiated astaxanthin-free system

In order to compare the combination component with the component (a) which is excellent in the deterioration preventing effect of astaxanthin, it is examination of whether the same effect can be obtained using various substances for the component (b) to the product of the present invention Inventions 1 to 5 and Comparatives 1 to 6)

  From the results of Tables 1 and 2, the present invention products 1 to 5 contained all of the components (a) and (b), and were excellent in the deterioration preventing effect. On the other hand, instead of the component (b), tri (caprylic capric acid) glyceryl (Triester F-810J: manufactured by Nippon Surfactant Industries Co., Ltd.), 1-propanol (:), 1-butanol (: ), T-Butanol (:), Isononyl isononanoate (Salacos 99: Nisshin Oillio Co., Ltd.), 2-Octyl Dodecan-1-ol (Co EUTANOL G: BASF), cetyl 2-ethylhexanoate (Salacos 816 T) : Nisshin Oillio Co., Ltd.) in combination, but in any case, the antifading effect is not excellent, and in order to suppress the deterioration of astaxanthin, the isopropanol which is the component (b) of the present invention is It became clear that it was necessary.

Example 2 [skin lotion]
(Component) (%)
1. Glycerin 5.0
2. 1,3-Butylene glycol 5.0
3. Lactic acid 0.05
4. Sodium lactate 0.1
5. Monooleic acid polyoxyethylene (20 moles) sorbitan 1.2
6. Ethanol 8.0
7. Isopropanol (Note 2) 0.01
8. ASTOTS-5O (Note 8) 0.001
9. Methyl parahydroxybenzoate 0.1
10. Fragrance 0.05
11. Purified water remaining amount (Note 8) Astaxanthin 5% solution (manufactured by Takeda Paper Co., Ltd.)

(Production method)
A: The components (5) to (10) are mixed and dissolved.
B: The components (1) to (4) and (11) are mixed and dissolved.
C: A was added to and mixed with B to obtain a lotion.

  The lotion of Example 2 was excellent in the stability of the carotenoid and was able to obtain the effects of the present invention.

Example 3 Latex
(Component) (%)
1. Polyoxyethylene (20 moles) sorbitan monostearate 1.0
2. Trioleic acid polyoxyethylene (20 moles) sorbitan 0.5
3. Glyceryl Monostearate 1.0
4. Isopropanol (Note 9) 3.0
5. Stearic acid 0.5
6. Behenyl alcohol 0.5
7. Squalane 4.0
8. Carboxy vinyl polymer 0.1
9. Methyl parahydroxybenzoate 0.1
10. Sodium hydroxide 0.05
11. Residual amount of purified water 12. Ethanol 5.0
13. 30% suspension of β-carotene (Note 10) 0.01
14. Fragrance 0.05
(Note 9) Tokuso IPA (made by Tokuyama Co., Ltd.)
(Note 10) Made by DSM Nutrition

(Production method)
A: Ingredients (1) to (7) are uniformly mixed at 70 ° C.
B: Ingredients (8) to (11) are uniformly mixed at 70 ° C.
C: Add A to B, emulsify, and cool to room temperature.
D: (12) to (14) were added and uniformly mixed to obtain an emulsion.

  The emulsion of Example 3 was excellent in the stability of the carotenoid and was able to obtain the effects of the present invention.

Example 4 [Liquid foundation (oil-in-water creamy)]
(Component) (%)
1.1,3 butylene glycol 5.0
2. Hydrogenated soybean phospholipids 0.5
3. Titanium oxide 5.0
4. Bengala 0.1
5. Yellow iron oxide 1.0
6. Black iron oxide 0.05
7. Acrylic acid / alkyl methacrylate copolymer (Note 11) 0.5
8. Triethanolamine 1.5
9. Residual amount of purified water 10. Glycerin 5.0
11. Ethyl parahydroxybenzoate 0.1
12. Stearic acid 0.9
13. Glycerin monostearate 0.3
14. Setostearyl alcohol 0.4
15. Monooleic acid polyoxyethylene (20 moles) sorbitan 0.2
16. Trioleic acid polyoxyethylene (20 moles) sorbitan 0.2
17. Paramethoxycinnamic acid 2-ethylhexyl 5.0
18. Isopropanol (Note 12) 2.0
19. ASTABIO AR1 (Note 13) 0.05
20. Ascorbyl tetradecadecanoate 0.05
21. α-Tocophenol 0.01
22. Flavoring agent 0.02
(Note 11) Pemulen TR-2 (made by NOVEON)
(Note 12) Isopropyl alcohol (Mitsui Chemical Co., Ltd.)
(Note 13) Astaxanthin 1% solution (Biogenic)

(Production method)
A: The components (1) to (6) are dispersed.
B: Add components (7) to (11) to A and mix uniformly at 70 ° C.
C: Ingredients (12) to (21) are uniformly mixed at 70 ° C.
D: Add B to C, emulsify, and cool to room temperature.
The component (22) was added to E: D to obtain an oil-in-water creamy liquid foundation.

  The liquid foundation (oil-in-water creamy) of Example 4 was excellent in the stability of the carotenoid and capable of obtaining the effects of the present invention.

Example 5 [Sunscreen cosmetic (water-in-oil cream-like)]
(Component) (%)
1. Monolaurate polyoxyethylene (20 moles) sorbitan 0.2
2. Polyoxyethylene (60 moles) hydrogenated castor oil 0.1
3. Remaining amount of purified water 4. Dipropylene glycol 10.0
5. Magnesium sulfate 0.5
6. Ascorbic acid glucoside 2.0
7. Silicone compound (Note 14) 3.0
8. Decamethylcyclopentasiloxane 20.0
9. Isotrinodecyl isononanoate 5.0
10. Paramethoxycinnamic acid 2-ethylhexyl 8.0
11. Isopropanol (Note 2) 3.0
12. Astaxanthin 5% oil (Note 15) 0.01
13. Dimethyl stearyl ammonium hectorite 1.2
(Note 14) KF-6028 (Shin-Etsu Chemical Co., Ltd.)
(Note 15) Astaxanthin 5% oil (manufactured by Bioactives Japan)

(Production method)
A: The components (1) to (6) are uniformly dispersed.
B: The components (7) to (13) are uniformly dispersed.
C: While stirring B, A was gradually added and emulsified to obtain a water-in-oil type cream sunscreen cosmetic.

  The sunscreen cosmetic (water-in-oil cream-like) of Example 5 was excellent in the stability of the carotenoid and capable of obtaining the effects of the present invention.

Example 6 [Ointment]
(Component) (%)
1. Triethanolamine 2.0
2. Glycerin 5.0
3. Dipotassium glycyrrhizinate (Note 16) 0.5
4. Residual amount of purified water Stearic acid 18.0
6. Settanol 4.0
7. Isopropanol (Note 2) 0.5
8. Astaxanthin (Note 1) 0.01
9. Acetic acid dl-α-tocopherol (Note 17) 0.2
10. Methyl parahydroxybenzoate 0.1
(Note 16) Maruzen Pharmaceutical Co., Ltd. (Note 17) Eisai Co., Ltd.

(Production method)
A. Dissolve components (1) to (4) uniformly and keep at 75 ° C.
B. Ingredients (5)-(10) are heat mixed and kept at 75 ° C.
C. To A was gradually added B to obtain an ointment.

  The ointment of Example 6 was excellent in the stability of the carotenoid and was able to obtain the effects of the present invention.

  Composition characterized by containing carotenoids such as astaxanthin and isopropanol according to the present invention, and further, external preparation for skin with enhanced stability of carotenoids such as astaxanthin by isopropanol, cosmetics, and suppression of deterioration of carotenoids such as astaxanthin The method is useful not only to improve the stability of a preparation such as astaxanthin in a preparation but also to exert effects on the skin such as antiaging, prevention and improvement of stains and the like.

Claims (6)

The following components (a) , (b) and (c) ;
(A) Astaxanthin or its ester having unique light absorption at wavelength 470 nm (b) isopropanol
(C) A composition which is a cosmetic or a skin external preparation containing a triester of a fatty acid having 8 to 12 carbon atoms and glycerin . Content weight ratio of components (a) and (b) (b) / ( a) is, according to claim 1 Symbol placement of the composition, characterized in that 100 to 5,000. The composition according to claim 1 or 2, further characterized in that component (c) is a triester of caprylic acid and / or capric acid with glycerin. Furthermore, vitamin E is contained as a component (d), The composition in any one of the Claims 1-3 characterized by the above-mentioned. Deterioration suppression of astaxanthin or its ester having specific light absorption at wavelength 470 nm using isopropanol , and triester of fatty acid having 8 to 12 carbon atoms and glycerin for use in a composition that is a cosmetic or a skin external preparation Agent. It is characterized by adding isopropanol and a triester of fatty acid having 8 to 12 carbon atoms with glycerin to a composition which is a cosmetic or a skin external preparation containing astaxanthin or an ester thereof having light absorption peculiar to a wavelength of 470 nm. A method for suppressing the deterioration of astaxanthin or an ester thereof.