JP4732871B2 - Iontophoresis device - Google Patents

Description

  The present invention relates to an iontophoresis device for administering drug ions to a living body.

  As described in Patent Document 1, the iontophoresis device as described above has a working electrode structure and a non-working electrode structure, and a chemical solution is supplied from the ion exchange membrane of the working electrode structure. It penetrates the skin and mucous membranes.

  The iontophoresis device as described above is intended for skin and mucous membranes with a diameter of about 30 mm even when it is large, and for example, avoids wounds and collects drug ions from the periphery or from the periphery of the eyeball. In the case of administration, etc., a plurality of working electrode structures must be used simultaneously.

  In addition, a configuration is possible in which a working electrode structure having a diameter of 60 mm or larger is made, and the central part of the tip is sealed, and drug ions are administered only from the periphery, but this is too wasteful.

  Further, in the conventional iontophoresis device, the area of the ion exchange membrane provided at the tip of the working electrode structure determines the chemical penetration area into the skin and mucous membrane. Each of the electrode structures is formed by sequentially stacking an ion exchange membrane of the same size cut in advance, a chemical solution holding unit, an electrolyte solution holding unit, a working electrode or a non-working side electrode, and the chemical solution holding unit also Since it is the same area as the chemical solution permeation area, there is a problem that the amount of the chemical solution that can be administered is limited by the area of the ion exchange membrane.

  Further, in the iontophoresis device described above, since the parts are sequentially stacked, there is a problem that the manufacturing process takes time.

WO03037425

  It is an object of the present invention to provide an iontophoresis device that can sufficiently administer drug ions in a ring shape in a wide range without unnecessarily increasing the area of the ion selective membrane. .

  It is another object of the present invention to provide an iontophoresis device that is easy to manufacture.

  (1) An iontophoresis device having a working electrode structure used for administering drug ions by iontophoresis, wherein the working electrode structure has the same kind of polarity as the drug ions. A working electrode having at least a drug solution holding part that is electrically connected to the working electrode and holds the drug ions, and the working electrode has a disk shape, an oblong disk shape, It is in any shape of a polygonal disk shape, the chemical solution holding part is arranged in an annular shape surrounding the outer periphery in the radial direction of the working side electrode, and the working side electrode structure has one end face in the thickness direction. An iontophoresis device characterized in that it is on the side in contact with a living body, and an inner portion of the one end face from the drug solution holding part is sealed by a working electrode side insulating member.

(2) the drug solution holding portion, the working side ion-selective membrane for selecting ions of the drug ions of the same kind, or impregnating the drug ions, either by applying the drug ions to the ion-selective membrane, The iontophoresis device according to (1), wherein the iontophoresis device is constituted by any one of a mixture of drug ions and a minute amount of gel.

  (3) An electrolyte solution holding unit and a working ion selective membrane that selects ions of the same type as the drug ions so as to surround the working electrode between the working electrode and the drug solution holding unit. The iontophoresis device according to (1), which is provided in order.

  (4) The working electrode side insulating member includes a working sealing material that seals a range from the inner periphery of the chemical solution holding unit to the working side electrode on the one end surface, and a working solution electrode from the chemical solution holding unit on the other end surface. An iontophoresis device according to any one of (1) to (3), characterized in that it comprises an insulating opposite-side action sealing material that seals the above range.

  (5) A working electrode structure and a non-working electrode structure used to administer drug ions by iontophoresis, and the working electrode structure and the non-working electrode structure with different polarities. The working electrode structure is electrically connected to the working electrode connected to the same kind of polarity as the drug ions in the direct current power supply. A drug solution holding unit that holds the drug ions, and a working ion-selective membrane that is disposed in front of the drug solution holding unit and selects ions of the same type as the drug ions. The side electrode structure includes the non-working side electrode connected to the polarity opposite to the drug ions in the DC power source, and the electrolyte solution holding unit that is electrically connected to the non-working side electrode and holds the electrolyte solution. And this A non-working-side ion-selective membrane that is arranged on the front surface of the solution holding unit and selects ions opposite to the drug ions, and the working-side electrode structure is centered on the working-side electrode. As described above, the chemical solution holding part and the working side ion selective membrane are configured to be laminated in this order in an annular shape, and one end face perpendicular to the central axis of the working side electrode is An iontophoresis device characterized in that the one end surface of the drug solution holding part and the working electrode is sealed by a working electrode side insulating member.

  (6) The working electrode side insulating member includes a working sealing material that seals a region inside the inner circumference of the working side ion selective membrane on the one end surface, and a working side ion selectivity on the other end surface. The iontophoresis device according to (5), further comprising an insulating opposite-side action sealing material that seals the other end face in the range of the chemical solution holding portion and the action-side electrode from the membrane.

  (7) In the non-working side electrode structure, the electrolyte solution holding part and the non-working side ion selective membrane are annularly laminated in this order so as to surround the non-working side electrode. And one end face of the electrolyte solution holding part and the non-working side electrode perpendicular to the central axis of the non-working side electrode is a contact side to the living body, and the electrolyte solution holding part and the non-working side The iontophoresis device according to (5) or (6), wherein the one end face of the electrode is sealed by a non-working electrode side insulating member.

  (8) The non-working electrode side insulating member includes a non-working sealing material that seals a range of the non-working side electrode from the electrolytic solution holding portion on the one end surface, and a non-working side ion-selective membrane on the other end surface. The iontophoresis device according to (7), further comprising: an insulative opposite non-acting sealing material that seals a range of the electrolyte holding unit and the non-acting electrode.

  (9) When viewed from the direction orthogonal to the one end face, the working electrode and the non-working electrode are adjacent to each other via an insulating separation sealing material, and are connected in a circular or non-circular continuous shape. The chemical solution holding part and the electrolyte solution holding part, and the working side ion selective membrane and the non-working side ion selective membrane are adjacent to each other and connected via a separation seal material, and the working side electrode and the non-working side The iontophoresis device according to (7) or (8), wherein an annular body surrounding the side electrodes concentrically in this order is formed.

  (10) The non-working electrode structure includes the non-working electrode and the non-working side ion selectivity so as to surround the non-working side electrode and the non-working side electrode surrounding the working-side ion selective membrane through an insulating material. The membrane is configured by laminating the layers in this order, and the non-working side electrode and the end face continuous with the one end face in the electrolyte solution holding portion are sealed by the working electrode side insulating member. The iontophoresis device according to (5) or (6), which is characterized.

  (11) The working electrode structure is disposed on the working electrode, on the outer peripheral side of the working electrode, and on the outer peripheral side of the electrolytic solution holding unit. , A second ion-selective membrane that selectively allows ions opposite to the drug ions to pass through, the medicinal solution holding unit disposed on the outer peripheral side of the second ion-selective membrane, and an outer peripheral side of the medicinal solution holding unit The iontophoresis device according to any one of (5) to (10), comprising the working-side ion selective membrane disposed.

  (12) Any two adjacent ones of the chemical solution holding unit, the second ion selective membrane, the electrolyte solution holding unit, and the working side electrode are arranged in the direction of the central axis of the working side ion selective membrane. The iontophoresis device according to (11), wherein

  (13) The non-working side electrode structure includes the non-working side electrode, a second electrolytic solution holding unit that is disposed on an outer peripheral side of the non-working side electrode, and holds the second electrolytic solution, and the second electrolysis A third ion-selective membrane that is arranged on the outer peripheral side of the liquid holding unit and selectively allows the same kind of ions as the drug ions to pass therethrough, and a third electrolyte solution holding that is arranged on the outer peripheral side of the third ion-selective membrane And the non-working side ion selective membrane disposed on the outer peripheral side of the third electrolyte solution holding unit. Iontophoresis device.

  (14) Out of the third electrolyte solution holding unit, the third ion selective membrane, the second electrolyte solution holding unit, and the non-working side electrode, any two adjacent ones are arranged at the center of the non-working side ion selective membrane. The iontophoresis device according to (13), wherein the iontophoresis device is disposed so as to overlap in an axial direction.

  (15) An iontophoresis device having a working electrode structure used for administering drug ions by iontophoresis and a non-working electrode structure opposite to the working electrode structure, the non-working side The electrode structure includes at least a non-working side electrode having a polarity opposite to that of the drug ion, and an electrolyte solution holding part that is electrically connected to the non-working side electrode and holds the electrolyte solution ion. In addition, the non-working side electrode has a disk shape, a long disk shape, or a polygonal disk shape, and the electrolyte solution holding portion has an annular shape surrounding an outer periphery in a radial direction of the non-working side electrode. The one end surface in the thickness direction is a contact side to the living body, and the inner side portion of the one end surface from the electrolyte solution holding portion is sealed by a non-working electrode side insulating member. Iontophoresis equipment .

  In this invention, the working electrode structure is formed by sequentially laminating a chemical solution holding unit, another ion selective membrane, an electrolyte solution holding unit, a working electrode, and the like on the inner peripheral side of the working ion selective membrane. Even if the outer diameter of the working ion-selective material on the outer periphery is large, drug ions can be administered in a ring or semi-ring over a wide range without wasting the area of the ion-selective membrane. can do. In addition, with the above-described configuration, it is possible to effectively administer drug ions from the vicinity thereof, avoiding sites where drug ions do not want to penetrate, such as wounds and eyeballs.

  In the iontophoresis device according to the best mode, the working electrode structure includes a chemical solution holding unit, a second ion selective membrane, and an electrolyte solution holding unit on the inner peripheral side of the annular first ion selective membrane. The non-working side electrode structure is arranged on the inner circumference side of the ring-shaped fourth ion-selective membrane on the inner circumference side of the ring-shaped fourth ion-selective membrane. The liquid holding part, the third ion selective membrane, and the second electrolyte holding part are arranged in this order by being laminated in a ring shape, and a non-working side electrode is provided at the center. The end surface of the human body that comes into contact with the skin and the like is sealed by the working electrode side insulating member except for the first ion-selective membrane portion, and similarly, the non-working side electrode structure on the contact side with the human skin and the like The end surface of the non-working electrode side insulating member was sealed except for the fourth ion selective membrane portion. And it has a formation.

  Hereinafter, an iontophoresis device according to Embodiment 1 of the present invention will be described in detail with reference to FIGS.

  The iontophoresis device 10 according to the first embodiment includes a working electrode structure 20 and a non-working electrode structure 40 used to administer an ionic drug by iontophoresis, and the working side thereof. A DC power source 12 connected to the electrode structure 20 and the non-working side electrode structure 40 with different polarities.

  The working electrode structure 20 includes a chemical solution holding unit 24, a second ion selective membrane 26, and an electrolyte solution holding unit 28 in order from the inner peripheral side of the annular first ion selective membrane 22 in a concentric manner. A circular working side electrode 30 is provided at the center, and is laminated in a ring shape inside.

  One end surface 13A of the working side electrode structure 20 (the lower side in FIG. 1 and the contact surface to the human skin etc.) is the inner side of the working electrode structure 20 except for the first ion selective membrane 22 portion. The circular region is sealed by the working electrode side insulating member 32. The other end surface 13B opposite to the one end surface 13A of the working side electrode structure 20 is supported in contact with an insulating working side base sheet 34 and sealed. Further, the outer periphery of the first ion selective membrane 22 is sealed with a side seal 34 </ b> A constituting a container together with the working side base sheet 34.

  The circular working electrode 30 provided at the center of the working electrode structure 20 is connected to the same kind of polarity as the drug ions in the DC power source 12 and is blended with a non-metallic conductive filler such as carbon paste, for example. It is comprised from the made electrically conductive paint. Although this working side electrode 30 can also be comprised with a copper plate or a metal thin film, since the metal eluted from this can transfer to a biological body at the time of chemical | medical agent administration, nonmetallic property is preferable.

  The electrolytic solution holding unit 28 has an electrolyte, and the electrolyte is more easily oxidized or reduced than water electrolysis (oxidation at the positive electrode and reduction at the negative electrode), for example, ascorbic acid (vitamin C). It is particularly preferable to use pharmaceutical agents such as sodium ascorbate, organic acids such as lactic acid, oxalic acid, malic acid, succinic acid, fumaric acid and / or salts thereof, thereby generating oxygen gas and hydrogen gas. In addition, it is possible to suppress fluctuations in pH during energization by blending a plurality of types of electrolytes that become buffer electrolytes when dissolved in a solvent.

  As the electrolyte solution holding unit 28, a carrier made of any material having water retention properties such as a fiber sheet such as gauze or filter paper, or a polymer gel sheet such as a hydrogel of acrylic resin (acrylic hydrogel) or a segmented polyurethane gel. Is impregnated with or contained in an electrolyte solution. Moreover, what hold | maintains electrolyte solution in a liquid state may be used, and electrolyte paint may be used.

  Further, the second ion-selective membrane 26 that selectively passes ions opposite to the drug ions is disposed outside the electrolyte solution holding unit 28, and outside the second ion-selective membrane, A chemical solution holding unit 24 for holding the ionic drug is disposed.

  The second ion-selective membrane 26 contains an ion exchange resin into which an ion exchange group having a counter ion of a conductivity type opposite to the drug ions in the drug solution holding unit 24, which will be described later, is introduced, and the drug solution holding unit 28 When an agent that dissociates into a drug ion that becomes a cation becomes an anion exchange resin, and conversely, when an agent that dissociates into a drug ion that becomes an anion becomes an agent Cation exchange resin is blended.

  The medicinal solution holding unit 24 contains a drug (including a drug precursor) in which the medicinal component dissociates into positive or negative ions (drug ions) when dissolved in a solvent such as water, and the medicinal component is a positive ion. Examples of the drug that dissociates into an anesthetic include lidocaine hydrochloride as an anesthetic and morphine hydrochloride as an anesthetic, and examples of a drug that dissociates into a negative ion of a medicinal component include ascorbic acid as a vitamin agent can do.

  Further, the chemical solution holding unit 24 is a carrier made of any material having water retention properties such as a fiber sheet such as gauze or filter paper, or a polymer gel sheet such as a hydrogel of acrylic resin (acrylic hydrogel) or a segmented polyurethane gel. Is impregnated with or containing a drug solution. Moreover, what hold | maintains a chemical | medical solution in a liquid state may be sufficient, and what apply | coated the medicine as a coating material may be used.

  In addition to the above, the drug held in the drug solution holding unit 24 includes hormones, DNA, RNA, proteins, amino acids, and minerals.

  The first ion-selective membrane 22 is configured to select ions of the same type as the drug ions, and an ion exchange group having a counter ion of the same conductivity type as the drug ions in the drug solution holding unit 24 is introduced. In the case where a drug that dissociates into a cation or an anion is used as the medicinal component of the drug solution holding unit 24, this is a cation exchange resin or an anion exchange resin.

  Examples of the cation exchange resin include polymers having a three-dimensional network structure such as hydrocarbon resins such as polystyrene resins and acrylic resins, and fluorine resins having a perfluorocarbon skeleton, sulfonic acid groups, and carboxylic acids. An ion exchange resin into which a cation exchange group such as a group or a phosphonic acid group (an exchange group in which the counter ion is a cation) is introduced can be used without limitation.

  The anion exchange resin includes a polymer having the same three-dimensional network structure as the cation exchange resin, a primary to tertiary amino group, a quaternary ammonium group, a pyridyl group, an imidazole group, a quaternary group. An ion exchange resin into which an anion exchange group such as a pyridinium group or a quaternary imidazolium group (an exchange group in which the counter ion is an anion) is introduced can be used without limitation.

  The non-working side electrode structure 40 includes a third electrolyte holding part 44, a third ion selective film 46, and a second electrolyte holding part concentrically from the inner periphery of the annular fourth ion selective film 42. 48 are sequentially laminated in an annular shape, and a circular non-working side electrode 50 is provided at the center.

  The non-working side electrode 50 in the non-working side electrode structure 40 is connected to the polarity opposite to the drug ion in the DC power supply 12.

  The second electrolyte solution holding part 48 is disposed outside the non-working side electrode 50 and holds the second electrolyte solution. Further, the third ion selective membrane 46 is disposed outside the second electrolyte solution holding unit 48 and is configured to selectively pass ions of the same type as the drug ions.

  The third electrolyte solution holding unit 44 is disposed outside the third ion selective membrane 46 and holds the third electrolyte solution. The fourth ion selective membrane 42 is disposed outside the third electrolyte solution holding unit 44 and is configured to selectively pass ions opposite to the drug ions.

  The non-working side electrode 50 has the same configuration as that of the working side electrode 30, and the configurations and components of the second electrolytic solution holding unit 48 and the third electrolytic solution holding unit 44 are the same as those of the electrolytic solution holding unit 28. It is the same.

  Further, the third ion selective membrane 46 contains the same first ion exchange resin as that forming the first ion selective membrane 22, and is the same as the first ion selective membrane 30. Functions as an ion selective membrane.

  The fourth ion selective membrane 42 is formed from an ion exchange resin contained in a second ion selective membrane similar to the above. The fourth ion selective membrane 42 functions as an ion selective membrane equivalent to the second ion selective membrane 26.

  One end face 40A on the lower side of the non-working side electrode structure 40 in FIG. 1 is an annular and insulating non-working electrode side seal except for the portion of the fourth ion selective membrane 42. Sealed by a material 52.

  The other end surface 40B opposite to the one end surface 40A is entirely sealed by a non-working side base sheet 54 (opposite side non-working sealing material). The outer periphery of the fourth ion selective membrane 42 is sealed with a side seal 54A that forms a container together with the non-working side base sheet 54.

  As the DC power source 12, for example, a button battery or a thin battery disclosed in, for example, Japanese Patent Application Laid-Open No. 11-067236, US Patent Publication No. 2004 / 0185667A1, US Pat. No. 6,855,441, or the like can be used. The structure of the embodiment is not limited.

  The DC power source 12 is disposed integrally with the working side electrode structure 20 or the non-working side electrode structure 40, and the DC power source 12, the working side electrode structure 20, and the non-working side electrode structure 40 are connected to each other. They are connected by lead wires 14.

  Note that the end surface of the first ion selective film 22 on the one end surface 12A side is substantially flush with the outer surface of the working electrode side insulating member 32. Similarly, the fourth ion selective film The end surface of one end surface 40A side of 42 is also configured to be substantially flush with the outer surface of the non-working electrode side insulating member 52.

  Note that an adhesive layer 56 may be provided on the outer surfaces of the working electrode side insulating member 32 and the non-working electrode side insulating member 52 so as to be in close contact with the skin and mucous membrane of a living body. For the pressure-sensitive adhesive layer 56, for example, a silicon-based pressure-sensitive adhesive mainly composed of polyorganosiloxane, polyacrylic acid, polyacrylic acid salt, polymethacrylic acid, polyethacrylic acid salt, or the like is used.

  In the iontophoresis device 10 according to the first embodiment, the first ion-selective membrane 22 is increased in diameter without providing a portion to which no drug solution can be administered, and for example, a skin wound or the like is torn and surrounded. As such, drug ions can be administered.

  In addition, the working electrode structure 20 and the non-working electrode structure 40 both have an ion-selective membrane, an electrolyte solution holding portion, an electrode, and the like arranged in a ring shape like a trunk in a tree. It can be manufactured easily and in large quantities by making a long piece in a direction perpendicular to the circle.

  Next, an iontophoresis device 60 according to Embodiment 2 of the present invention will be described with reference to FIG.

  In this iontophoresis device 60, a portion corresponding to the first ion selective membrane in the working electrode structure 62 is divided into a thin first ion exchange resin membrane 22A on the one end face 13A side and the other portion. The extension portion 22B is configured to overlap with the extension portion 22B, and the extension portion 22B is extended from the chemical solution holding portion 24.

  Further, in the non-working-side electrode structure 64, the portion corresponding to the fourth ion selective membrane is divided into the membrane-like fourth ion exchange resin membrane 42A on the one end face 40A side, and the upper portion in FIG. The extension portion 42 </ b> B from the third electrolyte solution holding portion 44.

  In this iontophoresis device 60, an extension 24A is added to the chemical solution holding unit 24 and an extension 44A is added to the third electrolyte solution holding unit 44, respectively, to increase the amount of drug solution to be administered. be able to.

  Next, a third embodiment of the present invention shown in FIG. 4 will be described.

  The iontophoresis device 80 according to the third embodiment includes a working electrode structure that is circular in a plan view and the non-action shown in the iontophoresis device 10 according to the first embodiment shown in FIGS. 1 and 2. The working electrode structure 82 and the non-working electrode structure 84, which are semicircular in plan view, equivalent to dividing the side electrode structure into two equal parts, are connected adjacently via an insulating isolation sealing material 86. In this state, it is configured to be circular in plan view.

  Accordingly, the iontophoresis device 80 is semicircular and has a first ion-selective membrane 22A and a fourth ion-selective membrane 42A that are connected via the separation sealing material 86. A third annular body 92 composed of an annular body 88, a second annular body 90 composed of the chemical solution retaining portion 24A and the third electrolyte retaining portion 44A, and a second ion selective membrane 26A and a third ion selective membrane 46A. And a fourth annular body 94 composed of the electrolyte solution holding part 28A and the second electrolyte solution holding part 48A. These are both semicircular in plan view, and the central circular shape composed of the working side electrode 30A and the non-working side electrode 50A connected via the separation sealing material 86 is concentrically in this order from the outside to the inside. It is configured to surround.

  In this iontophoresis device 80, first, a circular working electrode structure and a non-working electrode structure are formed in a plan view, and then divided into two along a diameter line to form a semicircular shape. The working-side electrode structure 82 and the non-working-side electrode structure 84 may be formed, and these may be connected so as to form a circle via the separation sealing material 86.

  Next, an iontophoresis device 100 according to Embodiment 4 of the present invention shown in FIG. 5 will be described.

  This iontophoresis device 100 is arranged on the outside of the working electrode structure 20 in the iontophoresis device 10 shown in FIGS. 1 and 2 so as to be concentrically surrounded by the non-working electrode structure 102. Is formed.

  An annular non-working side electrode 104 is provided adjacent to the outside of the first ion selective membrane 22 via an insulating material 106. That is, in the non-working side electrode structure 102, the non-working side electrode 104 is an annular body, and from this to the fourth ion selective membrane 42, the diameter is larger than that of the first embodiment in the same order as in the first embodiment. Is arranged in.

  Since other configurations are the same as those in the iontophoresis device 10, the same components as those in the first embodiment are denoted by the same reference numerals, and the description thereof is omitted.

  Next, an iontophoresis device 110 according to Embodiment 5 of the present invention shown in FIG. 6 will be described.

  The working electrode structure 112 of the iontophoresis device 110 includes a first ion selective membrane 116, a chemical solution replenishment layer 118, an inner liner 120, and a second ion selection on the inner peripheral side of the annular chemical solution holding unit 114. The conductive film 122 and the electrolytic solution holding part 124 are sequentially laminated in an annular shape, and a circular working electrode 126 is provided at the center.

  The ion selective membrane 116, the second ion selective membrane 122, the electrolytic solution holding unit 124, and the working electrode 126 are the first ion selective membrane 22, the second ion selective membrane 26, and the electrolytic solution in the first embodiment. Since it is the same structure as the holding | maintenance part 28 and the action | operation side electrode 30, description is abbreviate | omitted.

  The drug solution holding unit 114 is applied with the same drug ions as used in the drug solution holding unit 24 in the first embodiment. The chemical solution replenishment layer 118 is composed of similar drug ions.

  The inner liner 120 is made of release paper, release film, or the like, and prevents the chemical solution replenishment layer 118 and the second ion selective membrane 122 from coming into contact with each other. This prevents mixing of the drug and drug solution replenishment layer 118 due to diffusion of drug ions.

  Since the inner liner 120 is not sticky to the second ion-selective membrane 122, no release agent is required on the side in contact with the second ion-selective membrane 122. Therefore, the inner liner 120 may be a waterproof thin film.

  The lower end face in FIG. 6 of the working electrode structure 112 is inside the chemical solution holding portion 114, that is, in the range from the first ion selective film 116 to the working electrode 126. Is sealed by.

  The chemical solution holding portion 114 is exposed outside the action sealing material 128, and the exposed tip of the chemical solution holding portion 114 is sealed by an outer liner 130 that can be easily peeled off.

  In addition, the end surface of the working side electrode structure 112 opposite to the working sealing material 128, that is, the entire range from the working side electrode 126 to the outermost peripheral chemical liquid holding portion 114 is a single sheet serving as a working side base sheet. The opposite-side action insulating member 132 is sealed.

  The inner liner 120 is housed in two between the chemical solution replenishment layer 118 and the second ion selective membrane 122, and one end 120A of the working electrode structure 112 is shown in FIG. The inner liner 120 can be pulled out from between the chemical solution replenishment layer 118 and the second ion selective membrane 122 by being pulled upward.

  An end 120 </ b> A of the inner liner 120 that protrudes to the outside protrudes through the opposite-side action insulating member 132.

  The description of the configuration of the non-working side electrode structure 113 is omitted.

  When using the iontophoresis device 110 according to this embodiment, the outer liner 130 is peeled off to expose the chemical solution holding unit 114, and the inner liner 120 is pulled from the outside by pulling the end 120A. Withdrawn from between the chemical solution replenishment layer 118 and the second ion selective membrane 122, both are brought into contact with each other. As a result, ions different from the drug ions can move from the chemical solution replenishment layer 118 through the second ion selective membrane 122 to the electrolyte solution holding unit 124.

  In addition, although the said chemical | medical solution holding | maintenance part 114 is comprised from the drug ion apply | coated to the 1st ion selective membrane 116, this invention is not limited to this, For example, the said 1st ion selective membrane 116 may be impregnated with drug ions, or a mixture of drug ions and a small amount of gel may be provided outside the first ion selective membrane 116.

  According to each of the above embodiments, the diameter can be set large without wasting the central side of the first ion selective membrane or the chemical solution holding unit 114.

  In addition, when a chemical layer or the like is laminated on the ion selective membrane in the thickness direction as in the prior art, the thickness is inevitably increased and flexibility is lost. However, in the configuration of each of the above embodiments, the working electrode structure and / or Alternatively, the non-working side electrode structure can be thinned, and thus there is an effect that the skin followability during use is improved.

  Further, in each of the above embodiments, the width between the layers can be freely selected. For example, the electrode solution and the drug ions are mixed by widening the width of the ion selective membrane such as the ion selective membrane. You can avoid it.

  Furthermore, according to each of the above embodiments, each layer is formed in an annual ring shape in the trunk of the tree inside the annular chemical solution holding part or the first ion selective membrane on the outer periphery, And it can manufacture at low cost.

  For example, in the case of a working electrode structure, the working electrode, the electrolyte solution holding unit, the second ion selective membrane, the chemical solution holding unit, and the first ion selective membrane are applied in this order on the base sheet. After sequentially forming by sticking, printing, spraying, etc., the whole is formed in an annual ring shape, that is, in a roll shape, and then this is cut into rings, for example, the working side electrode as shown in FIG. A structure can be obtained.

  In Examples 1 to 5, the working electrode structure is formed from the first ion selective membrane, the chemical solution holding unit, the second ion selective membrane, the electrolytic solution holding unit, and the working electrode. The non-working side electrode structure is composed of a fourth ion-selective membrane, a third electrolyte solution holding unit, a third ion-selective membrane, a second electrolyte solution holding unit, and a non-working side electrode. However, the working electrode structure may be composed of a chemical solution holding part and a working electrode, and the first ion selective membrane, the chemical solution holding part, the working electrode, for example. It may be configured from.

  Further, in each of the embodiments, each layer constituting the working electrode structure or the non-working electrode structure is formed by sequentially laminating the ring from the center side, but the present invention is limited to this. The shape in plan view may be an oval, or a polygon such as a quadrangle or a hexagon. In this case, the shape of the working side electrode and / or the non-working side electrode or a combination thereof is a disc shape, an oblong disc shape, or a polygonal disc shape.

  Furthermore, between the outermost first ion selective membrane and the central working side electrode, or between the chemical solution holding part and the working side electrode, in the non-working side electrode structure, the fourth ion selective membrane and the non-working side. A plurality of layers between the side electrodes may be partially stacked in the thickness direction as in, for example, the iontophoresis device 140, 150, or 160 shown in FIGS.

  The iontophoresis device 140 is also supplied from the working electrode structure 142 and the non-working electrode structure 144, and the iontophoresis device 150 is supplied from the working electrode structure 152 and the non-working electrode structure 154. The lattice device 160 is composed of a working electrode structure 162 and a non-working electrode structure 164. 7 to 9, the same parts as those of the first embodiment are denoted by the same reference numerals, and the description thereof is omitted.

  In these cases, in order to make the electrical contact order the same as in each of the above embodiments, a sealing material 156 is provided on the side surface so as not to be short-circuited.

  In an iontophoresis device, electrical resistance mainly occurs at the interface of each layer, but depends on the contact area. In the configuration shown in FIGS. 7 to 9, part or all of the adjacent layers overlap in the thickness direction, and in this part, the contact area depends only on the printing accuracy and is easy to manage.

  The first ion selective membrane is composed of a membrane containing an ion exchange resin. However, the present invention is not limited to this, and ion selection has a function of selectively passing target ions. Any film may be used.

Sectional drawing which shows the iontophoresis apparatus which concerns on Example 1 of this invention. Plan view Sectional drawing similar to FIG. 1 which shows the iontophoresis apparatus based on Example 2 of this invention. The top view which shows the iontophoresis apparatus which concerns on Example 3 of this invention. The top view similar to FIG. 2 which shows the iontophoresis apparatus based on Example 4 of this invention. Sectional drawing similar to FIG. 1 which shows the iontophoresis apparatus based on Example 5 of this invention. Sectional drawing which shows typically the modification of the lamination | stacking method of the intermediate | middle layer in a working side electrode structure or a non-working side electrode structure Sectional drawing which shows the other modification schematically Sectional drawing which shows other modifications typically

Explanation of symbols

10, 60, 80, 90, 100, 110, 140, 150, 160 ... iontophoresis device 12 ... DC power supply 13A, 40A ... one end face 20, 62, 82, 112, 142, 152, 162 ... working side Electrode structure 22, 22A, 62, 116 ... first ion selective membrane 24, 24A, 114 ... chemical solution holding unit 26, 26A, 122 ... second ion selective membrane 28, 28A, 124 ... electrolyte solution holding unit 30, 30A, 126 ... working side electrode 32 ... working electrode side insulating member 34 ... working side base sheet (opposite side working sealing material)
40, 64, 84, 102, 113, 144, 154, 164 ... non-working side electrode structure 13B, 40B ... other end face 42, 42A, 64 ... fourth ion selective membrane 44, 44A ... third electrolyte holding Part 22A, 42A ... Extension part 46, 46A ... Third ion selective membrane 48, 48A ... Second electrolyte holding part 50, 50A, 104 ... Non-working side electrode 52 ... Non-working electrode side insulating member 54 ... Non-working side Base sheet (opposite non-acting sealing material)
56 ... Adhesive layer 86 ... Separation sealing material 88 ... First annular body 90 ... Second annular body 92 ... Third annular body 106 ... Insulating material 120 ... Inner liner 128 ... Working sealing material 132 ... Opposite working sealing material 156 ... Sealing material

Claims (15)

An iontophoresis device having a working electrode structure used to administer drug ions by iontophoresis,
The working electrode structure includes at least a working electrode having the same kind of polarity as the drug ion, and a drug solution holding part that is electrically connected to the working electrode and holds the drug ion. In addition, the working side electrode has a disk shape, a long disk shape, or a polygonal disk shape, and the chemical solution holding portion is arranged in an annular shape so as to surround the outer periphery in the radial direction of the working side electrode. In the working electrode structure, one end surface in the thickness direction is a contact side with a living body, and an inner portion of the one end surface from the liquid medicine holding portion is sealed by a working electrode side insulating member. A characteristic iontophoresis device. In claim 1,
The drug solution holding portion, the working side ion-selective membrane for selecting ions of the drug ions of the same kind, or impregnating the drug ions, either by applying the drug ions to the ion-selective membrane, and a drug ion An iontophoresis device comprising any one of a mixture with a minute amount of gel. In claim 1,
Between the working side electrode and the chemical solution holding unit, an electrolyte holding unit and a working side ion selective membrane that selects ions of the same kind as the drug ions are provided in this order so as to surround the working side electrode. An iontophoresis device characterized by that. In any one of Claims 1 thru | or 3,
The working electrode side insulating member includes a working sealing material for sealing a range from the inner periphery of the chemical solution holding unit to the working side electrode on the one end surface, and a range from the chemical solution holding unit to the working side electrode on the other end surface. An iontophoresis device, comprising: Working and non-working electrode structures used to administer drug ions by iontophoresis and are connected to these working and non-working electrode structures with different polarities DC power supply,
The working electrode structure includes a working electrode connected to the same kind of polarity as the drug ion in the DC power supply, and a drug solution holding unit electrically connected to the working electrode and holding the drug ion. And an ion selective membrane on the working side that is arranged on the front surface of the drug solution holding unit and selects ions of the same kind as the drug ions,
The non-working side electrode structure includes an electrolysis which is electrically connected to the non-working side electrode connected to the polarity opposite to the drug ion in the DC power source and holds the electrolytic solution. A liquid holding part, and a non-working side ion selective membrane that is arranged in front of the electrolyte holding part and selects ions opposite to the drug ions,
The working electrode structure is configured by laminating the drug solution holding portion and the working ion selective membrane in this order so as to surround the working electrode as a center, and One end surface orthogonal to the central axis of the working electrode is a contact side with a living body, and the one end surface of the drug solution holding part and the working electrode is sealed by a working electrode side insulating member. An iontophoresis device. In claim 5,
The working electrode-side insulating member includes a working sealing material that seals a region inside the inner periphery of the working-side ion-selective membrane on the one end surface, and a chemical solution from the working-side ion-selective membrane on the other end surface. An iontophoresis device comprising an insulating opposite-side action sealing material that seals the other end face in the range of the holding portion and the action-side electrode. In claim 5 or 6,
In the non-working side electrode structure, the electrolyte solution holding part and the non-working side ion-selective membrane are arranged in this order in an annular manner so as to surround the non-working side electrode. And one end surface orthogonal to the central axis of the non-working side electrode is a contact side to the living body, and the one end surface of the electrolyte solution holding part and the non-working side electrode is formed by a non-working electrode side insulating member. An iontophoresis device characterized by being sealed. In claim 7,
The non-working electrode side insulating member includes a non-working sealing material that seals a range of the non-working side electrode from the electrolyte solution holding portion on the one end face, and an electrolyte solution from the non-working side ion selective membrane on the other end face. An iontophoresis device comprising: a holding portion and an insulating non-working non-working sealing material that seals a range of the non-working side electrode. In claim 7 or 8,
Seen from the direction orthogonal to the one end face, the working electrode and the non-working side electrode are adjacent to each other through an insulating separation sealing material, and are connected in a circular or non-circular continuous shape,
The chemical solution holding part and the electrolyte solution holding part, and the working side ion selective membrane and the non-working side ion selective membrane are adjacent to each other via a separation sealing material, and the working side electrode and the non-working side electrode are connected. An iontophoresis device characterized by forming an annular body concentrically surrounding in this order. In claim 5 or 6,
The non-working side electrode structure includes the non-working side electrode and the non-working side ion selective membrane that surround the non-working side electrode and the non-working side electrode surrounding the working side ion selective membrane via an insulating material. The non-working side electrode and the end face continuous with the one end face of the electrolyte solution holding portion are sealed by the working electrode side insulating member. Iontophoresis device. In any of claims 5 to 10,
The working electrode structure is disposed on the working electrode, on the outer peripheral side of the working electrode, on the outer side of the electrolytic solution holding part, on the outer side of the electrolytic solution holding part, and on the drug A second ion-selective membrane that selectively allows ions opposite to the ions to pass therethrough, the chemical solution holding portion arranged on the outer peripheral side of the second ion selective membrane, and an outer peripheral side of the chemical solution holding portion An iontophoresis device comprising the working side ion selective membrane. In claim 11,
Any two adjacent ones of the chemical solution holding unit, the second ion selective membrane, the electrolyte solution holding unit, and the working side electrode are arranged so as to overlap each other in the direction of the central axis of the working side ion selective membrane. An iontophoresis device. In any of claims 5 to 10,
The non-working side electrode structure includes the non-working side electrode, a second electrolytic solution holding unit that is disposed on the outer peripheral side of the non-working side electrode, and holds the second electrolytic solution, and the second electrolytic solution holding unit A third ion-selective membrane that is arranged on the outer peripheral side of the first ion-selective membrane and selectively passes the same type of ions as the drug ions, and a third electrolyte solution holding unit that is arranged on the outer peripheral side of the third ion-selective membrane; An iontophoresis device comprising: the non-working-side ion selective membrane disposed on an outer peripheral side of the third electrolyte solution holding unit. In claim 13,
Of the third electrolyte solution holding part, the third ion selective membrane, the second electrolyte solution holding part, and the non-working side electrode, any two adjacent ones are arranged in the direction of the central axis of the non-working side ion selective film. An iontophoresis device characterized by being placed on top of each other. An iontophoresis device having a working electrode structure used to administer drug ions by iontophoresis and a non-working electrode structure opposite to the working electrode structure,
The non-working side electrode structure includes at least a non-working side electrode having a polarity opposite to that of the drug ions, and an electrolyte solution holding unit that is electrically connected to the non-working side electrode and holds electrolyte solution ions. And the non-working side electrode has a disk shape, a long disk shape, or a polygonal disk shape, and the electrolyte solution holding portion is a radially outer periphery of the non-working side electrode. The one end face in the thickness direction is a contact side to the living body, and the inner part of the one end face from the electrolyte solution holding part is sealed by the non-working electrode side insulating member. An iontophoresis device characterized by

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