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JP4556020B2 - 高い有効性を有するケモカインレセプタ結合複素環式化合物 - Google Patents

高い有効性を有するケモカインレセプタ結合複素環式化合物 Download PDF

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Publication number
JP4556020B2
JP4556020B2 JP2003556406A JP2003556406A JP4556020B2 JP 4556020 B2 JP4556020 B2 JP 4556020B2 JP 2003556406 A JP2003556406 A JP 2003556406A JP 2003556406 A JP2003556406 A JP 2003556406A JP 4556020 B2 JP4556020 B2 JP 4556020B2
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Japan
Prior art keywords
ylmethyl
benzimidazol
tetrahydro
quinolin
diamine
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Expired - Fee Related
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JP2003556406A
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Japanese (ja)
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JP2005518397A (ja
Inventor
ギャリー ジェイ． ブリドガー，
レナト ティー． スカールジ，
アル カラー，
カーティス ハーウィグ，
デービッド ボグッキ，
トレバー ウィルソン，
ジェーソン クラウフォード，
アーネスト ジェイ． マクイーカーン，
べム アツマ，
シチャオ ナン，
ユァンシ ジョウ，
ドミニク スコールズ，
クリストファー デニス スミス，
フルリ， ロザリア マリア ディ
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Genzyme Corp
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Genzyme Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

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JP2003556406A 2001-12-21 2002-12-23 高い有効性を有するケモカインレセプタ結合複素環式化合物 Expired - Fee Related JP4556020B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34271601P 2001-12-21 2001-12-21
US35082202P 2002-01-17 2002-01-17
PCT/US2002/041407 WO2003055876A1 (en) 2001-12-21 2002-12-23 Chemokine receptor binding heterocyclic compounds with enhanced efficacy

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JP2005518397A JP2005518397A (ja) 2005-06-23
JP4556020B2 true JP4556020B2 (ja) 2010-10-06

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US (2) US20030220341A1 (zh)
EP (1) EP1465889B1 (zh)
JP (1) JP4556020B2 (zh)
KR (1) KR20040068339A (zh)
CN (2) CN102153540A (zh)
AU (1) AU2002357379A1 (zh)
BR (1) BRPI0215050B8 (zh)
CA (1) CA2467718C (zh)
ES (1) ES2623982T3 (zh)
HU (1) HUP0402458A2 (zh)
IL (2) IL161784A0 (zh)
MX (1) MXPA04006136A (zh)
NO (1) NO20042578L (zh)
NZ (1) NZ533542A (zh)
PL (1) PL369856A1 (zh)
RU (1) RU2325387C2 (zh)
WO (1) WO2003055876A1 (zh)

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