JP4113093B2 - External preparation for skin containing ascorbic acids - Google Patents
External preparation for skin containing ascorbic acids Download PDFInfo
- Publication number
- JP4113093B2 JP4113093B2 JP2003366871A JP2003366871A JP4113093B2 JP 4113093 B2 JP4113093 B2 JP 4113093B2 JP 2003366871 A JP2003366871 A JP 2003366871A JP 2003366871 A JP2003366871 A JP 2003366871A JP 4113093 B2 JP4113093 B2 JP 4113093B2
- Authority
- JP
- Japan
- Prior art keywords
- mass
- external preparation
- skin
- acid
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 35
- 235000010323 ascorbic acid Nutrition 0.000 title claims description 30
- 150000000996 L-ascorbic acids Chemical class 0.000 title description 15
- 229920001296 polysiloxane Polymers 0.000 claims description 49
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 26
- 239000011668 ascorbic acid Substances 0.000 claims description 15
- 229960005070 ascorbic acid Drugs 0.000 claims description 15
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 11
- 150000005846 sugar alcohols Polymers 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 9
- 230000000844 anti-bacterial effect Effects 0.000 claims description 7
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 6
- 206010000496 acne Diseases 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 4
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- TXGJTWACJNYNOJ-UHFFFAOYSA-N hexane-2,4-diol Chemical compound CCC(O)CC(C)O TXGJTWACJNYNOJ-UHFFFAOYSA-N 0.000 claims description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- -1 ascorbic acid phosphate ester Chemical class 0.000 description 35
- 239000002537 cosmetic Substances 0.000 description 15
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 12
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 239000003921 oil Substances 0.000 description 9
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000004359 castor oil Substances 0.000 description 7
- 235000019438 castor oil Nutrition 0.000 description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 7
- 239000006096 absorbing agent Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 description 6
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 6
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 5
- 229940008099 dimethicone Drugs 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 4
- 235000019341 magnesium sulphate Nutrition 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 229960005323 phenoxyethanol Drugs 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 229920002907 Guar gum Polymers 0.000 description 3
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- 235000010417 guar gum Nutrition 0.000 description 3
- 239000000665 guar gum Substances 0.000 description 3
- 229960002154 guar gum Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 3
- 235000010378 sodium ascorbate Nutrition 0.000 description 3
- 229960005055 sodium ascorbate Drugs 0.000 description 3
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 3
- 239000007762 w/o emulsion Substances 0.000 description 3
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- XLTMWFMRJZDFFD-UHFFFAOYSA-N 1-[(2-chloro-4-nitrophenyl)diazenyl]naphthalen-2-ol Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC1=CC=C([N+]([O-])=O)C=C1Cl XLTMWFMRJZDFFD-UHFFFAOYSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- RKJGFHYCZPZJPE-UHFFFAOYSA-N 2,2-bis(16-methylheptadecanoyloxymethyl)butyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C RKJGFHYCZPZJPE-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
- NCLNAHJFXIKYBY-UHFFFAOYSA-N 2-hexyldecyl 16-methylheptadecanoate Chemical compound CCCCCCCCC(CCCCCC)COC(=O)CCCCCCCCCCCCCCC(C)C NCLNAHJFXIKYBY-UHFFFAOYSA-N 0.000 description 1
- MUHFRORXWCGZGE-KTKRTIGZSA-N 2-hydroxyethyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCO MUHFRORXWCGZGE-KTKRTIGZSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- FQCSIUSICFAMDD-UHFFFAOYSA-N 2-oxopyrrolidine-1-carboxylic acid;sodium Chemical compound [Na].OC(=O)N1CCCC1=O FQCSIUSICFAMDD-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- MSPJNHHBNOLHOC-UHFFFAOYSA-N 3,3-dimethylcyclopropane-1,2-dicarboxylic acid Chemical compound CC1(C)C(C(O)=O)C1C(O)=O MSPJNHHBNOLHOC-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
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- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
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- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 229940116985 potassium lauryl sulfate Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
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- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
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- 229940045870 sodium palmitate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
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- 229940032094 squalane Drugs 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
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- 229940117986 sulfobetaine Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- PDSVZUAJOIQXRK-UHFFFAOYSA-N trimethyl(octadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)C PDSVZUAJOIQXRK-UHFFFAOYSA-N 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
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- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
Landscapes
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- Cosmetics (AREA)
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Description
本発明は、皮膚外用剤に関し、更に詳細には、ニキビの予防と改善などに有用な、高濃度のアスコルビン酸、その誘導体又はそれらの塩を含有する皮膚外用剤に関する。 The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin containing a high concentration of ascorbic acid, a derivative thereof or a salt thereof useful for prevention and improvement of acne.
アスコルビン酸やその誘導体は、美白作用などの作用が存することが知られており、この目的で化粧料などの皮膚外用剤に１〜３質量％の濃度で含有されてきた。かかるアスコルビン酸類は、極めて高い安全性を有しているため、有用な美白剤であるが、最大の問題点は安定性であり、アスコルビン酸類の含有量が高くなるほど、分解、失活、着色の問題が著しくなった。この為、３質量％以上の高濃度で使用する場合には、経時において、その有効量を確保するために、増量して配合するのが常であった。近年、アスコルビン酸類には、４〜２０質量％と言う、更に高濃度域において、ニキビの改善作用や予防作用などの今まで知られていない作用が存することが明らかになっている（例えば、特許文献１を参照）。この様な有用性を実用化するためには、高濃度であってもアスコルビン酸を安定に含有できる剤形の開発が望まれていた。 Ascorbic acid and its derivatives are known to have an effect such as a whitening effect, and have been contained in skin external preparations such as cosmetics at a concentration of 1 to 3% by mass for this purpose. Such ascorbic acids are useful whitening agents because they have extremely high safety, but the biggest problem is stability.The higher the content of ascorbic acids, the more the decomposition, deactivation, and coloring. The problem became significant. For this reason, when used at a high concentration of 3% by mass or more, in order to ensure the effective amount over time, it was usual to increase the amount and blend. In recent years, the ascorbic acids, say 4-20 wt%, still in the high density region, the action previously unknown, such as improving effect and preventive effect of acne that that have revealed that exists (e.g., patent Reference 1) . In order to put such utility to practical use, it has been desired to develop a dosage form that can stably contain ascorbic acid even at a high concentration.
一方、架橋型ポリエーテル変性シリコーンは、油中水エマルションを作りやすい界面活
性剤として、化粧料分野で汎用されている（例えば、特許文献２、特許文献３、特許文献４を参照）。更に、この様な系では、低濃度で含有させた美白剤の経皮吸収が高まることも知られている（例えば、特許文献５を参照）。しかしながら、この様な架橋型ポリエーテル変性シリコーンを含有する系に、アスコルビン酸類を高濃度含有させると、極めて、アスコルビン酸類の安定性が向上することは全く知られていなかった。又、１）架橋型ポリエーテル変性シリコーンと２）アスコルビン酸、その誘導体及びそれらの塩から選択される１種乃至は２種以上を４〜２０質量％とを含有するものは全く知られていなかった。
On the other hand, (see e.g., Patent Document 2, Patent Document 3, Patent Document 4) Crosslinked polyether-modified silicone, which as easy surfactants make water-in-oil emulsion, that are commonly used in the cosmetic field. Further, in such systems, that it is also known that percutaneous absorption of whitening agents which contains a low concentration increases (e.g., see Patent Document 5). However, it has not been known at all that the stability of ascorbic acids is extremely improved when a high concentration of ascorbic acids is contained in a system containing such a crosslinked polyether-modified silicone. Moreover, what contains 4-20 mass% of 1 thru | or 2 or more types selected from 1) bridge | crosslinking type polyether modified silicone and 2) ascorbic acid, its derivative (s), and those salts is not known at all. It was.
本発明は、この様な状況下為されたものであり、高濃度にアスコルビン酸類を含有し、且つ、安定性に優れる皮膚外用剤の製剤を提供することを課題とする。 The present invention has been made under such circumstances, and an object of the present invention is to provide a preparation of an external preparation for skin which contains ascorbic acids at a high concentration and is excellent in stability.
本発明者らは、この様な状況に鑑みて、高濃度にアスコルビン酸類を含有し、且つ、安定性に優れる皮膚外用剤の製剤を求めて、鋭意研究努力を重ねた結果、１）架橋型ポリエーテル変性シリコーン１〜２０質量％と２）アスコルビン酸、その誘導体及びそれらの塩から選択される１種乃至は２種以上４〜２０質量％と３）抗菌性多価アルコール１２質量％以上とを含有する油中水乳化剤形の皮膚外用剤が、その様な特性を備えていることを見出し、発明を完成させるに至った。即ち、本発明は、以下に示す技術に関するものである。
（１）１）架橋型ポリエーテル変性シリコーン１〜２０質量％と２）アスコルビン酸、その誘導体及びそれらの塩から選択される１種乃至は２種以上４〜２０質量％と３）プロピレングリコール、ジプロピレングリコール、１，３−ブタンジオール、イソプレングリコール、１，２−ペンタンジオール、或いは２，４−ヘキシレングリコールから選択される１種乃至は２種以上の抗菌性多価アルコール１２質量％以上とを含有することを特徴とする、油中水乳化剤形の皮膚外用剤。
（２）ニキビの予防と改善用であることを特徴とする、（１）に記載の皮膚外用剤。
In view of such circumstances, the present inventors have intensively studied for a preparation of a skin external preparation containing ascorbic acids at a high concentration and having excellent stability. 1 to 20 mass% polyether-modified silicone and 2) ascorbic acid, its derivatives and one or two or more kinds on 4-20% by weight and 3) antibacterial polyhydric alcohols 12 wt% or more is selected from the salts thereof It has been found that a water-in-oil emulsifier type skin external preparation containing the above-mentioned properties has such characteristics, and has completed the invention. That is, this invention relates to the technique shown below.
(1) 1) Crosslinked polyether-modified silicone 1 to 20 mass% and 2) ascorbic acid, its derivatives and one or two or more kinds on 4-20% by weight and 3) propylene glycol are selected from their salts , Dipropylene glycol, 1,3-butanediol, isoprene glycol, 1,2-pentanediol, or 1,4-hexylene glycol, one or more antibacterial polyhydric alcohols 12% by mass above and the characterized in that it contains, skin external preparation of water-in-oil emulsifier type.
(2) The external preparation for skin according to (1) , which is used for prevention and improvement of acne.
本発明によれば、高濃度にアスコルビン酸類を含有し、且つ、安定性に優れる皮膚外用剤の製剤を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the formulation of the skin external preparation which contains ascorbic acid in high concentration and is excellent in stability can be provided.
＜１＞本発明の皮膚外用剤の必須成分である架橋型ポリエーテル変性シリコーン
本発明の油中水乳化組成物は架橋型ポリエーテル変性シリコーンを必須成分として含有する。
架橋型ポリエーテル変性シリコーンは三次元の結合を含むポリエーテル変性シリコーン類であり、ジメチコンポリオールクロスポリマーとして知られている。これらのシリコーンは既に既知の化合物であり、常法に従って製造することができる。又、この様な架橋型ポリエーテル変性シリコーンについては、既に市販されているものがあり、この様な市販品を利用することもできる。好ましい市販品としては、架橋型ポリエーテル変性シリコーンのジメチコン溶液（約２７重量％）である、シリコーンＫＳＧ−１５、シリコーンＫＦ６０１７、シリコーンＫＦ６０２８、シリコーンＫＳＧ−２１或いはシリコーンＫＳＧ−２１０（と何れも信越シリコーン株式会社製）等が例示できる。このほか、架橋型アルキルポリエーテル変性シリコーンの溶液である、シリコーンＫＳＧ−３１、シリコーンＫＳＧ−３２、シリコーンＫＳＧ−３３（何れも信越シリコーン株式会社製）なども使用することができる。
かかる架橋型ポリエーテル変性シリコーンは唯一種含有させることもできるし、二種以上を組み合わせて含有させることもできる。本発明の油中水乳化組成物に於ける架橋型ポリエーテル変性シリコーンの含有量は、油中水乳化組成物全量に対して、総量で１〜２０重量％であり、好ましくは３〜１０重量％であり、特に好ましくは４〜８重量％である。
<1> Crosslinked polyether-modified silicone which is an essential component of the external preparation for skin of the present invention The water- in- oil emulsion composition of the present invention contains a crosslinked polyether-modified silicone as an essential component.
Crosslinked polyether-modified silicone is a polyether-modified silicones including binding of a three-dimensional, known as di methicone crosspolymer. These silicones are already known compounds and can be produced according to conventional methods . In addition , some of such crosslinked polyether-modified silicones are already on the market, and such commercially available products can also be used. Preferred commercially, a cross-linking polyether-modified silicone dimethicone solution (about 27 wt%), silicone KSG-15, Silicone KF6017, silicone KF6028, silicone KSG-21 or silicone KSG-210 (a both-Etsu Silicone Co., Ltd.) can be exemplified. In addition, silicone KSG-31, silicone KSG-32, silicone KSG-33 (all manufactured by Shin-Etsu Silicone Co., Ltd.), which are solutions of crosslinked alkyl polyether-modified silicone, can also be used.
It can also take Crosslinked polyether-modified silicone is contained only species, may contain a combination of two or more. Containing Yuryou of at Crosslinked polyether-modified silicone water-in-oil emulsion composition of the present invention is to provide a water-in-oil emulsified composition total amount, from 1 to 20 wt% in total, good Mashiku 3 to 10% by weight der is, in particular, rather preferably is 4-8% by weight.
＜２＞本発明の皮膚外用剤の必須成分であるアスコルビン酸類
本発明の皮膚外用剤は、必須成分としてアスコルビン酸類を含有することを特徴とする。本発明の皮膚外用剤に於いて、用いることのできるアスコルビン酸類としては、アスコルビン酸、アスコルビン酸のリン酸エステル、アスコルビン酸グルコシドなどのアスコルビン酸の配糖体、該配糖体のアシル化体及びこれらの塩などが例示でき、塩としては、ナトリウム塩、カリウム塩等のアルカリ金属塩、カルシウム、マグネシウム等のアルカリ土類金属塩、アンモニウム塩、トリエタノールアミン塩、トリエチルアミン塩等の有機アミン塩類、リジン塩、アルギニン塩等の塩基性アミノ酸塩等が好ましく例示できる。これらの化合物群の内、特に好ましいものはアスコルビン酸リン酸エステル、アスコルビン酸グルコシド及びその塩から選択される１種乃至は２種以上であり、塩としてはマグネシウム塩、ナトリウム塩又はカリウム塩が好ましく例示できる。これらは唯一種を含有することも出来るし、二種以上を組み合わせて含有させることも出来る。かかるアスコルビン酸類の好ましい含有量は、総量で、皮膚外用剤全量に対して、４〜２０質量％であり、更に好ましくは、６〜１０質量％である。これは少なすぎると、美白作用以外の作用である、ニキビ等に対する改善或いは予防効果を発揮しない場合があり、多すぎても効果が頭打ちで皮膚刺激などの毒性を発現する場合があるからである。
<2> Ascorbic acids as essential components of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing ascorbic acids as an essential component. Ascorbic acids that can be used in the skin external preparation of the present invention include ascorbic acid, ascorbic acid phosphate ester, ascorbic acid glycoside such as ascorbic acid glucoside, acylated form of the glycoside, and Examples of these salts include alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium salts, triethanolamine salts, and triethylamine salts. Preferred examples include basic amino acid salts such as lysine salts and arginine salts. Of these compound groups, particularly preferred are one or more selected from ascorbic acid phosphate, ascorbic acid glucoside and salts thereof, and the salt is preferably a magnesium salt, sodium salt or potassium salt. It can be illustrated. These can contain only the seed | species, and can also be made to contain in combination of 2 or more type. The preferred content of such ascorbic acids is 4 to 20% by mass, and more preferably 6 to 10% by mass, based on the total amount of the external preparation for skin. This is because if the amount is too small, the effect other than the whitening effect may not show improvement or prevention effect for acne, etc., and if the amount is too large, the effect may reach its peak and may cause toxicity such as skin irritation. .
＜３＞本発明の皮膚外用剤
本発明の皮膚外用剤は、１）架橋型ポリエーテル変性シリコーン１〜２０質量％と２）アスコルビン酸、その誘導体及びそれらの塩から選択される１種乃至は２種以上４〜２０質量％と３）後記する抗菌性多価アルコール１２質量％以上とを含有することを特徴とする。本発明の皮膚外用剤においては、かかる必須成分以外に、通常化粧料などの皮膚外用剤で使用される任意成分を含有することが出来る。この様な任意成分としては、例えば、マカデミアナッツ油、アボガド油、トウモロコシ油、オリーブ油、ナタネ油、ゴマ油、ヒマシ油、サフラワー油、綿実油、ホホバ油、ヤシ油、パーム油、液状ラノリン、硬化ヤシ油、硬化油、モクロウ、硬化ヒマシ油、ミツロウ、キャンデリラロウ、カルナウバロウ、イボタロウ、ラノリン、還元ラノリン、硬質ラノリン、ホホバロウ等のオイル、ワックス類、流動パラフィン、スクワラン、プリスタン、オゾケライト、パラフィン、セレシン、ワセリン、マイクロクリスタリンワックス等の炭化水素類、オレイン酸、イソステアリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、ウンデシレン酸等の高級脂肪酸類、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、ベヘニルアルコール、オクチルドデカノール、ミリスチルアルコール、セトステアリルアルコール等の高級アルコール等、イソオクタン酸セチル、ミリスチン酸イソプロピル、イソステアリン酸ヘキシルデシル、アジピン酸ジイソプロピル、セバチン酸ジ−２−エチルヘキシル、乳酸セチル、リンゴ酸ジイソステアリル、ジ−２−エチルヘキサン酸エチレングリコール、ジカプリン酸ネオペンチルグリコール、ジ−２−ヘプチルウンデカン酸グリセリン、トリ−２−エチルヘキサン酸グリセリン、トリ−２−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ−２−エチルヘキサン酸ペンタンエリトリット等の合成エステル油類、ジメチルポリシロキサン、メチルフェニルポリシロキサン、ジフェニルポリシロキサン等の鎖状ポリシロキサン、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサンシロキサン等の環状ポリシロキサン、アミノ変性ポリシロキサン、ポリエーテル変性ポリシロキサン、アルキル変性ポリシロキサン、フッ素変性ポリシロキサン等の変性ポリシロキサン等のシリコーン油等の油剤類、脂肪酸セッケン（ラウリン酸ナトリウム、パルミチン酸ナトリウム等）、ラウリル硫酸カリウム、アルキル硫酸トリエタノールアミンエーテル等のアニオン界面活性剤類、塩化ステアリルトリメチルアンモニウム、塩化ベンザルコニウム、ラウリルアミンオキサイド等のカチオン界面活性剤類、イミダゾリン系両性界面活性剤（２−ココイル−２−イミダゾリニウムヒドロキサイド−１−カルボキシエチロキシ２ナトリウム塩等）、ベタイン系界面活性剤（アルキルベタイン、アミドベタイン、スルホベタイン等）、アシルメチルタウリン等の両性界面活性剤類、ソルビタン脂肪酸エステル類（ソルビタンモノステアレート、セスキオレイン酸ソルビタン等）、グリセリン脂肪酸類（モノステアリン酸グリセリン等）、プロピレングリコール脂肪酸エステル類（モノステアリン酸プロピレングリコール等）、硬化ヒマシ油誘導体、グリセリンアルキルエーテル、ＰＯＥソルビタン脂肪酸エステル類（ＰＯＥソルビタンモノオレエート、モノステアリン酸ポリオキエチレンソルビタン等）、ＰＯＥソルビット脂肪酸エステル類（ＰＯＥ−ソルビットモノラウレート等）、ＰＯＥグリセリン脂肪酸エステル類（ＰＯＥ−グリセリンモノイソステアレート等）、ＰＯＥ脂肪酸エステル類（ポリエチレングリコールモノオレート、ＰＯＥジステアレート等）、ＰＯＥアルキルエーテル類（ＰＯＥ２−オクチルドデシルエーテル等）、ＰＯＥアルキルフェニルエーテル類（ＰＯＥノニルフェニルエーテル等）、プルロニック型類、ＰＯＥ・ＰＯＰアルキルエーテル類（ＰＯＥ・ＰＯＰ２−デシルテトラデシルエーテル等）、テトロニック類、ＰＯＥヒマシ油・硬化ヒマシ油誘導体（ＰＯＥヒマシ油、ＰＯＥ硬化ヒマシ油等）、ショ糖脂肪酸エステル、アルキルグルコシド等の非イオン界面活性剤類、ポリエチレングリコール、グリセリン
、エリスリトール、ソルビトール、キシリトール、マルチトール、ジグリセリン等の多価アルコール類、ピロリドンカルボン酸ナトリウム、乳酸、乳酸ナトリウム等の保湿成分類、グアガム、クインスシード、カラギーナン、ガラクタン、アラビアガム、ペクチン、マンナン、デンプン、キサンタンガム、カードラン、メチルセルロース、ヒドロキシエチルセルロース、カルボキシメチルセルロース、メチルヒドロキシプロピルセルロース、コンドロイチン硫酸、デルマタン硫酸、グリコーゲン、ヘパラン硫酸、ヒアルロン酸、ヒアルロン酸ナトリウム、トラガントガム、ケラタン硫酸、コンドロイチン、ムコイチン硫酸、ヒドロキシエチルグアガム、カルボキシメチルグアガム、デキストラン、ケラト硫酸，ローカストビーンガム，サクシノグルカン，カロニン酸，キチン，キトサン、カルボキシメチルキチン、寒天、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、ポリアクリル酸ナトリウム、ポリエチレングリコール、ベントナイト等の増粘剤、表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸（シリカ）、酸化アルミニウム、硫酸バリウム等の粉体類、表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類、表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類、レーキ化されていても良い赤色２０２号、赤色２２８号、赤色２２６号、黄色４号、青色４０４号、黄色５号、赤色５０５号、赤色２３０号、赤色２２３号、橙色２０１号、赤色２１３号、黄色２０４号、黄色２０３号、青色１号、緑色２０１号、紫色２０１号、赤色２０４号等の有機色素類、ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類、パラアミノ安息香酸系紫外線吸収剤、アントラニル酸系紫外線吸収剤、サリチル酸系紫外線吸収剤、桂皮酸系紫外線吸収剤、ベンゾフェノン系紫外線吸収剤、糖系紫外線吸収剤、２−（２’−ヒドロキシ−５’−ｔ−オクチルフェニル)ベンゾトリアゾール、４−メトキシ−４’−ｔ−ブチルジベンゾイルメタン等の紫外線吸収剤類、エタノール、イソプロパノール等の低級アルコール類、ビタミンＡ又はその誘導体、ビタミンＢ6塩酸塩，ビタミンＢ6トリパルミテート，ビタミンＢ6ジオクタノエート，ビタミンＢ2又はその誘導体，ビタミンＢ12，ビタミンＢ15又はその誘導体等のビタミンＢ類、α−トコフェロール，β−トコフェロール，γ−トコフェロール，ビタミンＥアセテート等のビタミンＥ類、ビタミンＤ類、ビタミンＨ、パントテン酸、パンテチン、ピロロキノリンキノン等のビタミン類などが好ましく例示できる。これらの内、特に好ましい形態としては、水の含有量を極力抑えた形態であり、具体的には水の含有量を、水分の含有量が０〜１０質量％に抑える形態であり、より好ましくは０〜５質量％に抑える形態である。これは、既にアスコルビン酸類が水の存在によって、分解、着色を起こすことが知られているためであり、その様な反応を極力抑えた本発明の製剤においても、僅かながらのこの様な反応が観測されるためである。また本発明では、前記した如く、抗菌性多価アルコールを１２質量％以上含有させて、パラベンなどの防腐剤を含有させない形態が、スティギング発現を抑制させるので好ましい。ここで、抗菌性多価アルコールとは、微生物に対して、静菌的乃至は殺菌的に働く多価アルコール類の総称であり、プロピレングリコール、ジプロピレングリコール、１，３−ブタンジオール、イソプレングリコール、１，２−ペンタンジオール、２，４−ヘキシレングリコールなどが挙げられる。又、本発明の皮膚外用剤の剤形は、最外相に油相が存在する油中水乳化剤形乃至は多相乳化剤形である。この様な剤形を取ることにより、アスコルビン酸類の安定性を向上させることが出来る。又、本発明の皮膚外用剤が適用できる、皮膚外用剤の種類としては、例えば、化粧料（医薬部外品を含む）や皮膚外用医薬が好ましく例示できる。本発明の皮膚外用剤は安全性が非常に高いため、化粧料に適用することが特に好ましい。本発明の化粧料は、前記必須成分と、任意成分を常法に従って処理することにより製造することが出来る。かくして得られた本発明の皮膚外用剤は、高濃度のアスコルビン酸類を含有しているにもかかわらず、安定性に優れ、且つ、皮膚への刺激も非常に少ない。
<3> External preparation for skin of the present invention The external preparation for skin of the present invention is 1) 1 to 20% by mass of a crosslinked polyether-modified silicone and 2) one or more selected from ascorbic acid, its derivatives and salts thereof. characterized in that it contains a two or more kinds on 4-20% by weight and 3) antibacterial described later polyhydric alcohols 12 wt% or more. In the external preparation for skin of the present invention, optional components usually used in external preparations for skin such as cosmetics can be contained in addition to the essential components. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oils such as hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid esters, nonionic surfactants, polyethylene glycols such as alkyl glucoside, glycerin
, Et Risuritoru, sorbitol, xylitol, Maruchito Le, polyhydric alcohols such as di-glycerin, sodium pyrrolidone carboxylic acid, lactic acid, moisturizing ingredients, such as sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, Mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, Hydroxyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfuric acid, locust bean gum, saxi Glucan, caronic acid, chitin, chitosan, carboxymethylchitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, sodium polyacrylate, polyethylene glycol, bentonite and other thickeners, surface may be treated, mica , Talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate and other powders, surface may be treated, bengara, yellow iron oxide, black iron oxide Inorganic pigments of cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide, surface may be treated, pearl agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, may be raked Red No. 202, Red No. 228, Red No. 226, Yellow No. 4, Blue No. 404 Organics such as yellow 5, red 505, red 230, red 223, orange 201, red 213, yellow 204, yellow 203, blue 1, green 201, purple 201, red 204 Pigments, polyethylene powder, polymethyl methacrylate, nylon powder, organic powders such as organopolysiloxane elastomer, paraaminobenzoic acid UV absorber, anthranilic acid UV absorber, salicylic acid UV absorber, cinnamic acid UV UV rays such as absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane Absorbents, lower alcohols such as ethanol and isopropanol, vitamin A or its derivatives, vitamin B 6 hydrochloride Vitamin B 6 tripalmitate, vitamin B 6 dioctanoate, vitamin B 2 or derivatives thereof, vitamin B 12 such as vitamin B 12 , vitamin B 15 or derivatives thereof, α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E Preferred examples include vitamins such as acetate, vitamins D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone, and the like. Among these, a particularly preferable form is a form in which the water content is suppressed as much as possible. Specifically, the water content is a form in which the water content is suppressed to 0 to 10% by mass, and more preferable. Is a form that is suppressed to 0 to 5% by mass. This is because ascorbic acids are already known to be decomposed and colored by the presence of water. Even in the preparation of the present invention in which such a reaction is suppressed as much as possible, such a slight reaction is not possible. This is because it is observed. In the present invention, as described above, a form containing 12 % by mass or more of antibacterial polyhydric alcohol and not containing a preservative such as paraben is preferable because it suppresses the occurrence of stinging. Here, the antimicrobial polyhydric alcohol, to microorganisms, bacteriostatic or the Ri generically der polyhydric alcohol acts bactericidal, pro propylene glycol, dipropylene glycol, 1,3-butanediol, isoprene glycol, 1,2 Pentanjio Le, 2, 4-hexylene glycol. Moreover, the dosage form of the external preparation for skin of the present invention is a water-in-oil emulsifier type or a multiphase emulsifier type in which an oil phase is present in the outermost phase. By taking such a dosage form, the stability of ascorbic acids can be improved. Moreover, as a kind of skin external preparation which can apply the skin external preparation of this invention, cosmetics (a quasi-pharmaceutical product is included) and skin external preparation can be illustrated preferably, for example. Since the external preparation for skin of the present invention is very safe, it is particularly preferable to apply it to cosmetics. The cosmetic of the present invention can be produced by treating the essential components and optional components according to a conventional method. The skin external preparation of the present invention thus obtained has excellent stability and very little irritation to the skin despite containing a high concentration of ascorbic acids.
以下に、実施例を挙げて、本発明の皮膚外用剤について更に詳細に説明を加えるが、本発明が、かかる実施例にのみ限定されないことは言うまでもない。 The skin preparation for external use of the present invention will be described in more detail below with reference to examples, but it goes without saying that the present invention is not limited to such examples.
＜実施例１＞
以下に示す処方に従って、本発明の皮膚外用剤である化粧料（油中水乳化剤形）を作成した。即ち、イ、ロ、ハの成分をそれぞれ８０℃に加熱し、イにロを分散させ、これに攪拌しながらハを徐々に加え、ホモジナイザーで粒子を均一化し、攪拌冷却して本発明の化粧料１を得た。
イ
「シリコーンＫＳＧ−２１０」 ５ 質量部
「シリコーンＫＳＧ−１５」 ２ 質量部
「シリコーンＫＦ６０１７」 １ 質量部
有機変性ベントナイト ０．５質量部
ジメチコン １２ 質量部
ロ
１，３−ブタンジオール １５ 質量部
フェノキシエタノール ０．５質量部
硫酸マグネシウム ０．７質量部
アスコルビン酸リン酸ナトリウム ６ 質量部
ハ
水 ５７．３質量部
<Example 1>
A cosmetic (water-in-oil emulsifier form) which is an external preparation for skin of the present invention was prepared according to the formulation shown below. That is, the ingredients of A, B, and C are each heated to 80 ° C., and B is dispersed in A. The mixture is gradually added with stirring, the particles are homogenized by a homogenizer, and stirred and cooled to make the makeup of the present invention. Sample 1 was obtained.
A “silicone KSG-210” 5 parts by mass “silicone KSG-15” 2 parts by mass “silicone KF6017” 1 part by mass organically modified bentonite 0.5 part by mass dimethicone 12 parts by mass 1,3-butanediol 15 parts by mass phenoxyethanol 0 .5 parts by mass Magnesium sulfate 0.7 parts by mass Sodium ascorbate 6 parts by mass C. Water 57.3 parts by mass
＜試験例１＞
前記化粧料１と、このものの架橋型ポリエーテル変性シリコーンを、非架橋型のポリオール変性シリコーンに置換した比較例１と、単なるアスコルビン酸リン酸ナトリウムの水溶液である対照例１とを作成し、褐色瓶に充填し、４０℃で６ヶ月の保存試験を行い、残存量をＨＰＬＣで求めた。又、色差計により、５℃保存品との色差（ΔＥ）を測定した。結果を表１に示す。これより、本発明の皮膚外用剤である化粧料１は安定性に優れることが判る。
<Test Example 1>
The cosmetic 1 and the comparative example 1 in which the crosslinked polyether-modified silicone of this product was replaced with a non-crosslinked polyol-modified silicone and the control example 1 which was simply an aqueous solution of sodium ascorbate were prepared. The bottle was filled and subjected to a storage test for 6 months at 40 ° C., and the remaining amount was determined by HPLC. Further, the color difference (ΔE) with a product stored at 5 ° C. was measured with a color difference meter. The results are shown in Table 1. From this, it can be seen that the cosmetic 1 which is an external preparation for skin of the present invention is excellent in stability.
（比較例１）
非架橋ポリオール変性シリコーン ８ 質量部
有機変性ベントナイト ０．５質量部
ジメチコン １２ 質量部
ロ
１，３−ブタンジオール １５ 質量部
フェノキシエタノール ０．５質量部
硫酸マグネシウム ０．７質量部
アスコルビン酸リン酸ナトリウム ６ 質量部
ハ
水 ５７．３質量部
(Comparative Example 1)
Non-crosslinked polyol-modified silicone 8 parts by weight Organically modified bentonite 0.5 parts by weight dimethicone 12 parts by weight 1,3-butanediol 15 parts by weight phenoxyethanol 0.5 parts by weight Magnesium sulfate 0.7 parts by weight sodium ascorbate 6 parts by weight Part water 57.3 parts by mass
＜試験例２＞
パネラー１０名を用い、上腕内側部をガムテープで２回ストリッピングし、化粧料１、比較例１及び対照例１を２４時間クローズドパッチテストし、パッチ絆除去後３０分に皮膚反応を本邦パッチテスト基準に従って、観察、判定を行った。結果を表２に出現率として示す。これより、本発明の皮膚外用剤は安全性に優れることが判る。
（本邦パッチテスト基準）
＋＋：浮腫又は丘疹を伴う反応
＋ ：明瞭な紅斑を伴う反応
± ：紅斑が疑わしい反応を伴う反応
− ：無反応
<Test Example 2>
Using 10 panelists, strip the inner part of the upper arm twice with gummed tape, perform a 24-hour closed patch test on Cosmetic 1, Comparative Example 1 and Control Example 1, and test the skin reaction 30 minutes after removing the patch bond in Japan. Observation and judgment were performed according to the standard. The results are shown in Table 2 as the appearance rate. This shows that the skin external preparation of the present invention is excellent in safety.
(Japanese patch test standards)
++: reaction with edema or papules +: reaction with clear erythema ±: reaction with suspicion of erythema-: no reaction
＜実施例２＞
化粧料１と同様に下記に示す処方に従って、化粧料２を作成した。このものについて、試験例１、試験例２と同様に評価した。比較例２は、化粧料２の架橋型ポリエーテル変性シリコーンを、非架橋型のポリオール変性シリコーンに置換したものであり、対照例２はアスコルビン酸−２−グルコシドの単なる水溶液である。評価結果を表３、４に示す。本発明の皮膚外用剤は安定性と安全性に優れることが判る。
イ
「シリコーンＫＳＧ−２１０」
５ 質量部
「シリコーンＫＳＧ−１５」
２ 質量部
「シリコーンＫＦ６０１７」
１ 質量部
有機変性ベントナイト
０．５質量部
ジメチコン
１２ 質量部
ロ
１，３−ブタンジオール
１５ 質量部
フェノキシエタノール
０．５質量部
硫酸マグネシウム
０．７質量部
アスコルビン酸−２−グルコシド
６ 質量部
ハ
水
５７．３質量部
<Example 2>
In the same manner as cosmetic 1, cosmetic 2 was prepared according to the formulation shown below. This was evaluated in the same manner as Test Example 1 and Test Example 2. Comparative Example 2 is obtained by replacing the crosslinked polyether-modified silicone of cosmetic 2 with a non-crosslinked polyol-modified silicone, and Control Example 2 is a simple aqueous solution of ascorbic acid-2-glucoside. The evaluation results are shown in Tables 3 and 4. It can be seen that the external preparation for skin of the present invention is excellent in stability and safety.
I "Silicone KSG-210"
5 parts by mass "silicone KSG-15"
2 parts by mass "Silicone KF6017"
1 part by weight Organically modified bentonite 0.5 part by weight dimethicone 12 part by weight 1,3-butanediol 15 part by weight phenoxyethanol 0.5 part by weight magnesium sulfate 0.7 part by weight ascorbic acid-2-glucoside 6 parts by weight ha water 57 .3 parts by mass
＜実施例３〜５＞
化粧料２の抗菌性多価アルコールを他のものに置換して、化粧料３〜５を作成し、その４０℃６ヶ月の保存状況での安定性（残存率）を調べた。結果を表５に示す。何れの多価アルコールも使用可能であることが判る。
イ
「シリコーンＫＳＧ−２１０」 ５ 質量部
「シリコーンＫＳＧ−１５」 ２ 質量部
「シリコーンＫＦ６０１７」 １ 質量部
有機変性ベントナイト ０．５質量部
ジメチコン １２ 質量部
ロ
表５に記載の多価アルコール １５ 質量部
フェノキシエタノール ０．５質量部
硫酸マグネシウム ０．７質量部
アスコルビン酸−２−グルコシド ６ 質量部
ハ
水 ５７．３質量部
<Examples 3 to 5 >
The antibacterial polyhydric alcohol in cosmetic 2 was replaced with another to prepare cosmetics 3 to 5 , and the stability (residual rate) in the storage state at 40 ° C. for 6 months was examined. The results are shown in Table 5. It can be seen that any polyhydric alcohol can be used.
A “silicone KSG-210” 5 parts by mass “silicone KSG-15” 2 parts by mass “silicone KF6017” 1 part by mass Organically modified bentonite 0.5 parts by mass dimethicone 12 parts by mass Polyhydric alcohol described in Table 5 15 parts by mass Phenoxyethanol 0.5 parts by weight Magnesium sulfate 0.7 parts by weight Ascorbic acid-2-glucoside 6 parts by weight Ha water 57.3 parts by weight
本発明は、ニキビの予防、改善に有用な、安全で安定な皮膚外用剤に適用できる。 INDUSTRIAL APPLICABILITY The present invention can be applied to a safe and stable external preparation for skin useful for preventing and improving acne.
Claims (2)
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| JP2003366871A JP4113093B2 (en) | 2003-10-28 | 2003-10-28 | External preparation for skin containing ascorbic acids |
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| JP2009517478A (en) * | 2005-12-02 | 2009-04-30 | ザ プロクター アンド ギャンブル カンパニー | Water-in-oil emulsion composition containing siloxane elastomer |
| CN101442981A (en) * | 2006-05-15 | 2009-05-27 | 宝洁公司 | Method of enhancing penetration of water-soluble actives |
| CN102846599B (en) * | 2011-06-30 | 2018-08-10 | 日本乐敦制药株式会社 | Topical composition |
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