JP2015525071A5 - - Google Patents
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- Publication number
- JP2015525071A5 JP2015525071A5 JP2015516160A JP2015516160A JP2015525071A5 JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5 JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- human immunoglobulin
- chain variable
- heavy chain
- genetically engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 44
- 102000038129 antigens Human genes 0.000 claims description 44
- 108091007172 antigens Proteins 0.000 claims description 44
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 39
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 39
- 229920001850 Nucleic acid sequence Polymers 0.000 claims description 26
- 150000007523 nucleic acids Chemical group 0.000 claims description 24
- 210000004602 germ cell Anatomy 0.000 claims description 22
- 210000004027 cells Anatomy 0.000 claims description 21
- 101710009640 IGKV1D-8 Proteins 0.000 claims description 20
- 101710024481 IGKV2-29 Proteins 0.000 claims description 20
- 101710009635 IGKV2D-26 Proteins 0.000 claims description 20
- 102100005978 IGKV3-20 Human genes 0.000 claims description 20
- 101710024987 IGKV3-20 Proteins 0.000 claims description 20
- 101710009651 IGKV3D-15 Proteins 0.000 claims description 20
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 13
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 13
- 102000025417 antigen binding proteins Human genes 0.000 claims description 12
- 108091000829 antigen binding proteins Proteins 0.000 claims description 12
- 230000003053 immunization Effects 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 238000006011 modification reaction Methods 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- 210000003719 B-Lymphocytes Anatomy 0.000 claims 2
- 102100008989 IGHV1-2 Human genes 0.000 claims 2
- 101710003461 IGHV1-2 Proteins 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/488,628 | 2012-06-05 | ||
| US13/488,628 US20130045492A1 (en) | 2010-02-08 | 2012-06-05 | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| PCT/US2013/044257 WO2013184761A1 (en) | 2012-06-05 | 2013-06-05 | Methods for making fully human bispecific antibodies using a common light chain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015525071A JP2015525071A (ja) | 2015-09-03 |
| JP2015525071A5 true JP2015525071A5 (hr) | 2016-07-21 |
Family
ID=48652344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516160A Pending JP2015525071A (ja) | 2012-06-05 | 2013-06-05 | 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2854523A1 (hr) |
| JP (1) | JP2015525071A (hr) |
| KR (1) | KR20150023535A (hr) |
| CN (1) | CN104582476B (hr) |
| AU (1) | AU2013271737A1 (hr) |
| CA (1) | CA2874846A1 (hr) |
| HK (1) | HK1208994A1 (hr) |
| IL (1) | IL235781A0 (hr) |
| MX (1) | MX2014014891A (hr) |
| RU (1) | RU2014153674A (hr) |
| SG (2) | SG11201407644UA (hr) |
| WO (1) | WO2013184761A1 (hr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| KR101829691B1 (ko) | 2010-02-08 | 2018-02-19 | 리제너론 파마슈티칼스 인코포레이티드 | 일반적인 경쇄 마우스 |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| CN107361011B (zh) | 2012-03-16 | 2021-08-27 | 瑞泽恩制药公司 | 制备表达ph敏感性免疫球蛋白序列的非人动物的方法 |
| US9301510B2 (en) | 2012-03-16 | 2016-04-05 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with pH-dependent binding characteristics |
| HUE053310T2 (hu) | 2012-03-16 | 2021-06-28 | Regeneron Pharma | Hisztidinmódosított könnyûlánc antitestek és genetikailag módosított rágcsálók ugyanennek az elõállítására |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| SG10201913376XA (en) | 2012-04-20 | 2020-02-27 | Merus Nv | Methods and means for the production of ig-like molecules |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| EP2970437A1 (en) * | 2013-03-13 | 2016-01-20 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| SI3221359T1 (sl) | 2014-11-17 | 2020-08-31 | Regeneron Pharmaceuticals, Inc. | Metode zravljenja tumorja z uporabo bispecifičnega protitelesa CD3XCD20 |
| KR20170087486A (ko) * | 2014-11-20 | 2017-07-28 | 에프. 호프만-라 로슈 아게 | 일반 경쇄 및 이의 사용 방법 |
| EP3023437A1 (en) * | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| PL3277725T3 (pl) | 2015-03-30 | 2021-06-14 | Regeneron Pharmaceuticals, Inc. | Regiony stałe łańcucha ciężkiego o zmniejszonym wiązaniu do receptorów Fc gamma |
| US10520511B2 (en) | 2015-05-12 | 2019-12-31 | Regeneron Pharmaceuticals, Inc. | Multimeric protein purity determination |
| JP7023231B2 (ja) * | 2015-09-23 | 2022-02-21 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 最適化抗ｃｄ３二重特異性抗体及びその使用 |
| MX2018008701A (es) | 2016-01-13 | 2019-06-06 | Regeneron Pharma | Roedores que tienen una region de diversidad de cadena pesada modificada geneticamente. |
| WO2019241692A1 (en) | 2018-06-14 | 2019-12-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
| IL280875B1 (en) | 2018-08-31 | 2024-08-01 | Regeneron Pharma | Cytokine Release Syndrome Attenuating Dosing Strategy for Bispecific Antibodies to CD3 and CD20 |
| CN113302207A (zh) * | 2018-11-16 | 2021-08-24 | 维尔托索宾科公司 | Cd38和icam1抗体及其用途 |
| CA3127153A1 (en) | 2019-02-22 | 2020-08-27 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| WO2022056276A1 (en) | 2020-09-11 | 2022-03-17 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| CA3199879A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| CN116635413A (zh) | 2020-12-23 | 2023-08-22 | 再生元制药公司 | 用于获得结合跨膜蛋白的抗体的方法和生产所述抗体的细胞 |
| US20220195014A1 (en) | 2020-12-23 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN118496357A (zh) * | 2023-02-15 | 2024-08-16 | 康源博创生物科技(北京)有限公司 | 一种多肽以及包含其作为轻链的抗体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE190355T1 (de) * | 1988-09-06 | 2000-03-15 | Xoma Corp | Genexpressions-elemente und herstellung von chimären maus-mensch-antikörpern |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU6819494A (en) * | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CA2491864C (en) * | 2001-07-12 | 2012-09-11 | Jefferson Foote | Super humanized antibodies |
| PT1298207E (pt) * | 2001-10-01 | 2010-11-08 | Deutsches Krebsforsch | Processo para a produção de bibliotecas de proteínas e para a selecção de proteínas a partir da mesma |
| AU2003214842A1 (en) * | 2002-01-17 | 2003-09-02 | Albert Einstein College Of Medicine Of Yeshiva University | Mutations caused by activation-induced cytidine deaminase |
| WO2003106495A2 (en) * | 2002-06-14 | 2003-12-24 | Immunomedics, Inc. | MONOCLONAL ANTIBODY hPAM4 |
| CN101962408A (zh) * | 2002-07-12 | 2011-02-02 | 杰斐逊·富特 | 超人源化抗体 |
| LT3456190T (lt) * | 2008-06-27 | 2022-03-10 | Merus N.V. | Antikūną produkuojantis transgeninis pelių pošeimio gyvūnas |
| KR101829691B1 (ko) * | 2010-02-08 | 2018-02-19 | 리제너론 파마슈티칼스 인코포레이티드 | 일반적인 경쇄 마우스 |
| WO2013022782A1 (en) * | 2011-08-05 | 2013-02-14 | Regeneron Pharmaceuticals, Inc. | Humanized universal light chain mice |
-
2013
- 2013-06-05 CA CA2874846A patent/CA2874846A1/en not_active Abandoned
- 2013-06-05 EP EP13729875.8A patent/EP2854523A1/en not_active Ceased
- 2013-06-05 CN CN201380030014.1A patent/CN104582476B/zh active Active
- 2013-06-05 JP JP2015516160A patent/JP2015525071A/ja active Pending
- 2013-06-05 AU AU2013271737A patent/AU2013271737A1/en not_active Abandoned
- 2013-06-05 RU RU2014153674A patent/RU2014153674A/ru not_active Application Discontinuation
- 2013-06-05 MX MX2014014891A patent/MX2014014891A/es unknown
- 2013-06-05 SG SG11201407644UA patent/SG11201407644UA/en unknown
- 2013-06-05 SG SG10201609535TA patent/SG10201609535TA/en unknown
- 2013-06-05 KR KR20147036869A patent/KR20150023535A/ko not_active Application Discontinuation
- 2013-06-05 WO PCT/US2013/044257 patent/WO2013184761A1/en active Application Filing
-
2014
- 2014-11-18 IL IL235781A patent/IL235781A0/en unknown
-
2015
- 2015-10-06 HK HK15109745.2A patent/HK1208994A1/xx unknown
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