JP2015131784A - skin care lotion - Google Patents
skin care lotion Download PDFInfo
- Publication number
- JP2015131784A JP2015131784A JP2014004828A JP2014004828A JP2015131784A JP 2015131784 A JP2015131784 A JP 2015131784A JP 2014004828 A JP2014004828 A JP 2014004828A JP 2014004828 A JP2014004828 A JP 2014004828A JP 2015131784 A JP2015131784 A JP 2015131784A
- Authority
- JP
- Japan
- Prior art keywords
- skin care
- effect
- lotion
- mass
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Landscapes
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Abstract
Description
本発明は、スキンケアのために使用されるクリーム、化粧水、乳液等のローションに関するものであり、詳しくは、優れたシワ・シミ取り効果、美白効果、日焼け防止効果、皮膚炎の改善効果を発現可能なスキンケア用ローションに関するものである。 The present invention relates to lotions such as creams, lotions and emulsions used for skin care, and in particular, exhibits excellent wrinkle and stain removal effects, whitening effects, sun protection effects, and dermatitis improvement effects. It relates to possible skin care lotions.
顔面の皮膚老化を防いで、シワ・シミ取り効果や美白効果を発現させるためのスキンケア用ローションとして、ビタミンＣ、ビタミンＥ、ＳＯＤ（スーパーオキシドジスムターゼ）、カタラーゼ等の抗酸化剤、グリチルリチン酸等の抗炎症剤、各種の紫外線吸収剤、α−ヒドロキシカルボン酸、胎盤抽出液、γ−アミノ−β−ヒドロキシ酪酸等の細胞賦活成分、コラーゲン、エラスチン、ヒアルロン酸等の細胞外マトリックス成分、尿素等の保湿剤等を含有したものが知られている。また、特許文献１の如く、生理活性成分を含有したものも提案されている。 Skin care lotion to prevent facial skin aging, wrinkle / scratch removal and whitening effects such as vitamin C, vitamin E, SOD (superoxide dismutase), catalase and other antioxidants, glycyrrhizic acid, etc. Anti-inflammatory agents, various ultraviolet absorbers, α-hydroxycarboxylic acid, placenta extract, cell activation components such as γ-amino-β-hydroxybutyric acid, extracellular matrix components such as collagen, elastin, hyaluronic acid, urea, etc. The thing containing a moisturizer etc. is known. In addition, as disclosed in Patent Document 1, one containing a physiologically active ingredient has been proposed.
しかしながら、上記従来のスキンケア用ローションは、必ずしもシワ・シミ取り効果や美白効果が十分であるとは言えない。また、十分なシワ・シミ取り効果や美白効果を発現させるために、使用量を多くすると、皮膚への刺激が強くなり、場合によっては、却って皮膚が炎症を起こしてしまうこともある。 However, it cannot be said that the conventional skin care lotion has sufficient wrinkle and stain removal effects and whitening effects. In addition, when the amount used is increased in order to exhibit a sufficient wrinkle / smear removing effect and whitening effect, irritation to the skin becomes stronger, and in some cases, the skin may become inflamed.
本発明の目的は、上記従来のスキンケア用ローションが有する問題点を解消し、優れたシワ・シミ取り効果、美白効果を奏するのみならず、日焼け防止効果、皮膚炎（アトピー性皮膚炎等）の改善効果をも奏する実用性の高いスキンケア用ローションを提供することにある。 The object of the present invention is to solve the problems of the conventional skin care lotion and not only have excellent wrinkle and stain removal effects and whitening effects, but also prevent sunburn, dermatitis (atopic dermatitis, etc.) The object is to provide a skin care lotion with high practicality that also has an improvement effect.
本発明の内、請求項１に記載された発明は、スキンケアのために使用されるクリーム、化粧水、乳液等のローションであって、プロポリスおよびアミノ酸を含有することを特徴とするものである。 Among the present inventions, the invention described in claim 1 is a lotion such as cream, lotion, milky lotion and the like used for skin care, and is characterized by containing propolis and amino acids.
請求項２に記載された発明は、請求項１に記載された発明において、アミノ酸が、システイン、アルギニン、リシンあるいはそれらの誘導体の内の１種、または２種以上を混合してなるものであることを特徴とするものである。 The invention described in claim 2 is the invention described in claim 1, wherein the amino acid is formed by mixing one or more of cysteine, arginine, lysine or derivatives thereof. It is characterized by this.
請求項３に記載された発明は、請求項１、または請求項２に記載された発明において、ヒアルロン酸を含有することを特徴とするものである。 The invention described in claim 3 is characterized in that the invention described in claim 1 or claim 2 contains hyaluronic acid.
請求項４に記載された発明は、請求項１〜３のいずれかに記載された発明において、フコイダンを含有することを特徴とするものである。 The invention described in claim 4 is characterized in that in the invention described in any one of claims 1 to 3, fucoidan is contained.
請求項５に記載された発明は、請求項１〜４のいずれかに記載された発明において、アミノ酸に対するプロポリス（固形分）の添加比率が、５％以上２０％未満であることを特徴とするものである。 The invention described in claim 5 is characterized in that, in the invention described in any one of claims 1 to 4, the ratio of addition of propolis (solid content) to amino acid is 5% or more and less than 20%. Is.
本発明に係るスキンケア用ローションは、優れたシワ取り作用、美肌化、美白化作用を有する。その上、顔や手足に薄く塗布するだけで、効果的に日焼けを防止することができるので、皮膚ガン発症の抑制および皮膚ガンの症状の改善にも効果を奏する。加えて、皮膚炎（アトピー性皮膚炎等）の症状の改善にも優れた効果を奏する。 The lotion for skin care according to the present invention has excellent wrinkle removing action, skin beautification, and whitening action. In addition, it is possible to effectively prevent sunburn by simply applying it thinly on the face and limbs, which is effective in suppressing the onset of skin cancer and improving the symptoms of skin cancer. In addition, it has an excellent effect in improving the symptoms of dermatitis (atopic dermatitis and the like).
本発明に係るスキンケア用ローションは、プロポリスおよびアミノ酸を含有することを特徴とするものである。本発明でいうプロポリス（Propolis）とは、植物が分泌した種々の物質をミツバチが採集して営巣に用いる粘着性の物質のことであり、所謂、蜂ヤニのことである。本発明に係るスキンケア用ローションには、このプロポリスの固形分濃度が１０％〜３０％の抽出溶液（エタノール溶液等）を、０．０１〜１５質量％含有させるのが好ましく、３．０〜１０質量％含有させるのがより好ましい（したがって、固形分濃度としては、０．００１質量％〜４．５質量％含有させるのが好ましく、０．３質量％〜３．０質量％含有させるのがより好ましい）。また、プロポリスの抽出溶液としては、固形分濃度が約２０％の抽出溶液を用いるのが最も好ましい。プロポリスの添加量が、上記した範囲を下回ると（固形分濃度が０．００１質量％を下回ると）、十分なシワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果が得られないので好ましくなく、プロポリスの添加量が、上記した範囲を上回ると（固形分濃度が４．５質量％を上回ると）、不経済である上、皮膚に塗布した際のべとつき感が高くなったり、スキンケア用ローションの臭いが不良となったりするので好ましくない。 The skin care lotion according to the present invention is characterized by containing a propolis and an amino acid. The term “propolis” as used in the present invention refers to a sticky substance that a bee collects and uses for nesting various substances secreted by plants, and is a so-called bee crabs. The skin care lotion according to the present invention preferably contains 0.01 to 15% by mass of an extraction solution (ethanol solution or the like) having a solid content concentration of propolis of 10% to 30%, preferably 3.0 to 10%. More preferably, it is contained (the solid content concentration is preferably 0.001% to 4.5% by mass, more preferably 0.3% to 3.0% by mass). preferable). As the propolis extraction solution, it is most preferable to use an extraction solution having a solid concentration of about 20%. When the amount of propolis added falls below the above range (when the solid content concentration falls below 0.001% by mass), sufficient wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, dermatitis improvement effect Is not preferable, and if the amount of propolis added exceeds the above range (if the solid content concentration exceeds 4.5% by mass), it is uneconomical and the sticky feeling when applied to the skin It is not preferable because it becomes high and the odor of the lotion for skin care becomes poor.
また、本発明に係るスキンケア用ローションには、アミノ酸を含有させることが必要である。かかるアミノ酸としては、アラニン、アルギニン、アスパラギン、アスパラギン酸、システイン、グルタミン、グルタミン酸、グリシン、ヒスチジン、イソロイシン、ロイシン、リシン（リジンとも称される）、メチオニン、フェニルアラニン、プロリン、セリン、トレオニン、トリプトファン、チロシン、バリン、ギャバ（γ−アミノ酪酸）の２１種類のアミノ酸の内のＬタイプのもの、あるいはそれらの塩酸塩、硫酸塩等の誘導体等を用いることができるが、システイン、アルギニン、リシン、トレオニン、アスパラギン酸、ギャバ、あるいはそれらの誘導体の内の１種、または２種以上を混合してなるものであると、少ない分量で、効率的にシワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果を発揮することが可能となるので好ましい。加えて、システイン、アルギニン、リシンを混合して用いると、非常に高いシワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果が得られるので好ましい。また、本発明に係るスキンケア用ローションにおいてプロポリスとともに用いるアミノ酸として、システイン（Ｌ−システイン）、アルギニン（Ｌ−アルギニン）、リシン（Ｌ−リシン）あるいはそれらの塩酸塩（もしくはそれらの内の1種または２種以上の組み合わせ）を用いると、きわめて高いシワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果が得られるので好ましい。 Further, the skin care lotion according to the present invention needs to contain an amino acid. Such amino acids include alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine (also referred to as lysine), methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine. , Valine, gaba (γ-aminobutyric acid) of 21 types of amino acids, L type derivatives thereof, derivatives thereof such as hydrochloride, sulfate, etc. can be used, cysteine, arginine, lysine, threonine, A mixture of one or more of aspartic acid, GABA, or their derivatives effectively removes wrinkles and stains, enhances skin and whitening, and tans in a small amount. Demonstrate prevention effect, dermatitis improvement effect It is preferable because it is possible. In addition, it is preferable to use a mixture of cysteine, arginine, and lysine because a very high wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, and dermatitis improvement effect can be obtained. Moreover, as an amino acid used with propolis in the skin care lotion according to the present invention, cysteine (L-cysteine), arginine (L-arginine), lysine (L-lysine), or a hydrochloride thereof (or one of them or Use of a combination of two or more types is preferable because an extremely high wrinkle / stain removal effect, skin beautification / whitening effect, sunburn preventing effect, and dermatitis improving effect can be obtained.
本発明に係るスキンケア用ローションには、上記したアミノ酸（あるいはその誘導体）を、０．０５〜１０質量％含有させるのが好ましく、０．１〜５質量％含有させるのがより好ましい。アミノ酸またはその誘導体の含有量が、上記した範囲を下回ると、プロポリスとの相乗作用が得られず、十分なシワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果が得られないので好ましくなく、アミノ酸またはその誘導体の含有量が、上記した範囲を上回ると、不経済である上、却って皮膚の炎症を誘発してしまう虞れがあるので好ましくない。 The lotion for skin care according to the present invention preferably contains 0.05 to 10% by mass, more preferably 0.1 to 5% by mass of the above-described amino acid (or a derivative thereof). If the content of amino acids or derivatives thereof is below the above range, synergy with propolis cannot be obtained, and sufficient wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, dermatitis improvement effect Since it cannot be obtained, it is not preferable. If the content of the amino acid or its derivative exceeds the above range, it is not preferable because it is not economical and may cause skin inflammation.
一方、本発明に係るスキンケア用ローションにおけるアミノ酸に対するプロポリス（純成分）の添加比率は、特に限定されないが、当該添加比率が０．１％以上１００％未満であると、プロポリスとアミノ酸との相乗作用によって、より高いシワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果が得られるので好ましく、３％〜３０％であると一層好ましく、５％〜２０％であると特に好ましい。 On the other hand, the addition ratio of the propolis (pure component) to the amino acid in the skin care lotion according to the present invention is not particularly limited, but if the addition ratio is 0.1% or more and less than 100%, the synergistic action of the propolis and the amino acid The higher wrinkle / stain removal effect, skin beautification / whitening effect, sunburn prevention effect, and dermatitis improvement effect are preferable, and 3% to 30% is more preferable, and 5% to 20% is preferable. Particularly preferred.
さらに、本発明に係るスキンケア用ローションには、保湿、抗菌、血行促進、腐敗防止の目的で、植物エキスを添加するのが好ましい。当該植物エキスとしては、各種のものを用いることができるが、クララ葉エキス、ショウガ根エキス（ショウキョウエキス）、センキュウエキス、トウキエキス（トウキ根エキス）、オタネニンジン根エキスを用いるのが好ましい。特に、クララ葉エキスを添加すると、保湿、血行促進、抗菌、抗酸化、皮膚の収斂、止痒等の作用効果の他に、美白、日焼け防止、日焼け後の皮膚の修復等の効果も得られるので好ましく、ショウガ根エキスを添加すると、血行促進、抗菌、抗酸化、止痒等の作用効果が得られるので好ましく、センキュウエキスを添加すると、消炎、鎮静、血行促進等の作用効果が得られるので好ましく、トウキエキスを添加すると、保湿、抹消血管拡張、血行促進、抗炎症、抗アレルギー、強壮、鎮痛等の作用効果の他に、美白効果も得られる上、抗腫瘍効果も期待できるので好ましく、モモ葉エキスを添加すると、保湿、抗菌、抗酸化、消炎、皮膚の収斂、刺激緩和等の作用効果が得られるので好ましく、オタネニンジン根エキスを添加すると、代謝促進、血行促進等の作用効果の他に、シワ防止、肌荒れ防止等の効果も得られるので好ましい。 Furthermore, it is preferable to add a plant extract to the skin care lotion according to the present invention for the purpose of moisturizing, antibacterial, blood circulation promotion and anti-corruption. As the plant extract, various types can be used, but it is preferable to use a clara leaf extract, a ginger root extract (a ginger extract), a senkyu extract, a ginger extract (a ginger root extract), or a ginseng root extract. In particular, when Clara leaf extract is added, in addition to the effects of moisturizing, blood circulation promotion, antibacterial, antioxidant, skin astringency, antipruritic, etc., effects such as whitening, sunburn prevention, and skin repair after sunburn are also obtained. Therefore, the addition of ginger root extract is preferable because it can provide effects such as blood circulation promotion, antibacterial, antioxidant, antipruritic and the like, and the addition of senkyu extract provides effects such as anti-inflammatory, sedation, blood circulation promotion, etc. Preferably, the addition of Toki extract is preferable because it can be expected to have a whitening effect and an antitumor effect in addition to the effects of moisturizing, peripheral vasodilation, blood circulation promotion, anti-inflammatory, anti-allergy, tonic, analgesia, etc. Addition of peach leaf extract is preferable because it provides effects such as moisturizing, antibacterial, antioxidant, anti-inflammatory, skin convergence, and alleviation of irritation. Addition of ginseng root extract promotes metabolism. Preferred other operational effects such as blood circulation, anti-wrinkle, so also obtained effects such as skin roughness preventing.
また、上記した植物エキスは、単独で用いることもできるが、２種類以上混合して用いると、それらの植物エキスの相乗的な作用によって、少量の添加により効率的に保湿、抗菌、血行促進、腐敗防止等の効果を発現させることが可能となるので好ましい。加えて、植物エキスの添加量は、特に限定されないが、固形分の合計で０．１〜５質量％添加するのが好ましく、０．５〜３質量％添加するのがより好ましい。植物エキスの添加量が０．１質量％を下回ると、十分な保湿、抗菌、血行促進、腐敗防止効果等が得られないので好ましくなく、反対に、植物エキスの添加量が５質量％を上回ると、不経済である上、スキンケア用ローションの外観や臭いが不良となる虞れがあるので好ましくない。 In addition, the above-mentioned plant extracts can be used alone, but when used in a mixture of two or more, the moisturizing, antibacterial, blood circulation promotion, Since it becomes possible to express effects, such as prevention of corruption, it is preferable. In addition, although the addition amount of a plant extract is not specifically limited, It is preferable to add 0.1-5 mass% in total of solid content, and it is more preferable to add 0.5-3 mass%. If the added amount of the plant extract is less than 0.1% by mass, it is not preferable because sufficient moisturizing, antibacterial, blood circulation promotion, anti-corrosion effect, etc. cannot be obtained, and conversely, the added amount of the plant extract exceeds 5% by mass. This is not preferable because it is not economical and the appearance and odor of the skin care lotion may be poor.
さらに、本発明に係るスキンケア用ローションには、必須成分であるプロポリス、アミノ酸の他に、通常スキンケア用ローションに用いられる成分、たとえば、油性成分、合成系あるいは天然物系の界面活性剤、保湿剤、防腐剤（抗菌・殺菌剤）、粉体成分、紫外線吸収剤、抗酸化剤、色素、香料等を、必要に応じて適宜配合することができる。加えて、本発明に係るスキンケア用ローションには、必要に応じて、各種のアルコールや発酵アルコール、グリコール類（ブチルグリコール等）、増粘剤（粘度調整剤）、ＰＨ調整剤等を添加することも可能である。 Further, the skin care lotion according to the present invention includes, in addition to propolis and amino acids, which are essential components, components commonly used in skin care lotions, such as oily components, synthetic or natural product surfactants, moisturizers. Preservatives (antibacterial / bactericidal agents), powder components, ultraviolet absorbers, antioxidants, pigments, fragrances and the like can be appropriately blended as necessary. In addition, various alcohols, fermented alcohols, glycols (such as butyl glycol), thickeners (viscosity modifiers), pH adjusters, etc. may be added to the skin care lotion according to the present invention as necessary. Is also possible.
油性成分としては、たとえば、オリーブ油、ホホバ油、ヒマシ油、大豆油、米油、米胚芽油、ヤシ油、パーム油、カカオ油、メドウフォーム油、シアーバター、ティーツリー油、アボガド油、マカデミアナッツ油、植物由来スクワラン等の植物由来の油脂類、ミンク油、タートル油等の動物由来の油脂類、ミツロウ、カルナウバロウ、ライスワックス、ラノリン等のロウ類、流動パラフィン、ワセリン、パラフィンワックス、スクワラン等の炭化水素類、ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、イソステアリン酸、ｃｉｓ−１１−エイコセン酸等の脂肪酸類、ラウリルアルコール、セタノール、ステアリルアルコール等の高級アルコール類、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、オレイン酸ブチル、２−エチルヘキシルグリセライド、高級脂肪酸オクチルドデシル（ステアリン酸オクチルドデシル等）等の合成エステル類および合成トリグリセライド類等を好適に用いることができる。 Examples of oil components include olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cacao oil, meadow foam oil, sheer butter, tea tree oil, avocado oil, macadamia nut oil , Plant-derived oils and fats such as plant-derived squalane, animal-derived oils and fats such as mink oil and turtle oil, waxes such as beeswax, carnauba wax, rice wax, lanolin, liquid paraffin, petrolatum, paraffin wax, squalane, etc. Hydrogens, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, fatty acids such as cis-11-eicosenoic acid, higher alcohols such as lauryl alcohol, cetanol, stearyl alcohol, isopropyl myristate, isopropyl palmitate, Butyl oleate, 2 Ethylhexyl glycerides, etc. can be suitably used synthetic esters and synthetic triglycerides such as higher fatty acid octyldodecyl (octyl stearate dodecyl).
界面活性剤としては、たとえば、ポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビトール脂肪酸エステル等の非イオン界面活性剤、脂肪酸塩、アルキル硫酸塩、アルキルベンゼンスルホン酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレン脂肪アミン硫酸塩、ポリオキシエチレンアルキルフェニルエーテル硫酸塩、ポリオキシエチレンアルキルエーテル燐酸塩、α−スルホン化脂肪酸アルキルエステル塩、ポリオキシエチレンアルキルフェニルエーテル燐酸塩等のアニオン界面活性剤、第四級アンモニウム塩、第一級〜第三級脂肪アミン塩、トリアルキルベンジルアンモニウム塩、アルキルピリジニウム塩、２−アルキル−１−アルキル−１−ヒドロキシエチルイミダゾリニウム塩、Ｎ，Ｎ−ジアルキルモルフォルニウム塩、ポリエチレンポリアミン脂肪酸アミド塩等のカチオン界面活性剤、Ｎ，Ｎ−ジメチル−Ｎ−アルキル−Ｎ−カルボキシメチルアンモニオベタイン、Ｎ，Ｎ，Ｎ−トリアルキル−Ｎ−アルキレンアンモニオカルボキシベタイン、Ｎ−アシルアミドプロピル−Ｎ′，Ｎ′−ジメチル−Ｎ′−β−ヒドロキシプロピルアンモニオスルホベタイン等の両性界面活性剤等を使用することができる。 Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, Nonionic surfactants such as polyoxyethylene sorbitol fatty acid esters, fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates , Polyoxyethylene alkyl ether phosphate, α-sulfonated fatty acid alkyl ester salt, polyoxyethylene alkyl phenyl ether phosphate, etc. Surfactants, quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N , N-dialkylmorphonium salts, cationic surfactants such as polyethylene polyamine fatty acid amide salts, N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N- Amphoteric surfactants such as alkylene ammoniocarboxybetaine and N-acylamidopropyl-N ′, N′-dimethyl-N′-β-hydroxypropylammoniosulfobetaine can be used.
また、乳化剤や乳化助剤として、酵素処理ステビア等のステビア誘導体、レシチンおよびその誘導体、乳酸菌醗酵米、乳酸菌醗酵発芽米、乳酸菌醗酵穀類（麦類、豆類、雑穀等）、ジュアゼイロ（Rhamnaceae zizyphus joazeiro)抽出物等を配合することもできる。 In addition, as emulsifiers and emulsifiers, stevia derivatives such as enzyme-treated stevia, lecithin and derivatives thereof, lactic acid bacteria fermented rice, lactic acid bacteria fermented rice, lactic acid bacteria fermented cereals (wheat, legumes, cereals, etc.), juzairo (Rhamnaceae zizyphus joazeiro) An extract or the like can also be blended.
保湿剤としては、たとえば、グリセリン、プロピレングリコール、ジプロピレングリコール、１，３−ブチレングリコール、ポリエチレングリコール、ソルビトール、キシリトール、ピロリドンカルボン酸ナトリウム等があり、さらにトレハロース等の糖類、乳酸菌醗酵米、ムコ多糖類（たとえば、ヒアルロン酸およびその誘導体、コンドロイチンおよびその誘導体、ヘパリンおよびその誘導体等）、エラスチンおよびその誘導体、コラーゲンおよびその誘導体、ＮＭＦ関連物質、乳酸、尿素、高級脂肪酸オクチルドデシル、海藻抽出物、ビャッキュウ抽出物、魚介類由来コラーゲンおよびその誘導体、各種アミノ酸およびそれらの誘導体が挙げられる。 Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidonecarboxylate, and sugars such as trehalose, lactic acid bacteria fermented rice, mucopoly Sugars (for example, hyaluronic acid and its derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, NMF related substances, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extract, seaweed extract Examples include extracts, seafood-derived collagen and derivatives thereof, various amino acids and derivatives thereof.
増粘剤としては、たとえば、アルギン酸、寒天、カラギーナン、緑藻または紅藻由来成分（海藻エキス）、ビャッキュウ抽出物、ペクチン、ローカストビーンガム、アロエ多糖体等の多糖類、キサンタンガム、トラガントガム、グアーガム等のガム類、カルボキシメチルセルロース、ヒドロキシエチルセルロース等のセルロース誘導体、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、アクリル酸・メタクリル酸共重合体等の合成高分子類、ヒアルロン酸およびその誘導体、ポリグルタミン酸およびその誘導体等を好適に用いることができる。 Examples of the thickening agent include alginic acid, agar, carrageenan, green algae or red algae-derived components (seaweed extract), beech extract, pectin, locust bean gum, polysaccharides such as aloe polysaccharide, xanthan gum, tragacanth gum, guar gum, etc. Gum, cellulose derivatives such as carboxymethyl cellulose, hydroxyethyl cellulose, synthetic polymers such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, acrylic acid / methacrylic acid copolymer, hyaluronic acid and its derivatives, polyglutamic acid and its derivatives, etc. Can be suitably used.
防腐剤（抗菌・殺菌剤）としては、たとえば、尿素、パラオキシ安息香酸メチル（メチルパラベン）、パラオキシ安息香酸エチル（エチルパラベン）、パラオキシ安息香酸プロピル（プロピルパラベン）、パラオキシ安息香酸ブチル（ブチルパラベ）等のパラオキシ安息香酸エステル類、フェノキシエタノール、ジクロロフェン、ヘキサクロロフェン、塩酸クロルヘキシジン、塩化ベンザルコニウム、サリチル酸、エタノール、ウンデシレン酸、フェノール類、ジャマール（イミダゾデイニールウレア）、１，２−ペンタンジオール、各種精油類、樹皮乾留物等を好適に用いることができる。加えて、それらの防腐・殺菌剤の中でも、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン等のパラベン類を単独であるいは２種類以上を混合して用いると、少量の添加により効果的に腐敗を防止することが可能となるので好ましい。パラベン類を防腐剤として用いる場合の添加量は、特に限定されないが、合計で０．１〜１０質量％添加するのが好ましく、０．５〜５質量％添加するのがより好ましい。パラベン類の添加量が０．１質量％を下回ると、十分な腐敗防止効果が得られないので好ましくなく、反対に、パラベン類の添加量が１０質量％を上回ると、不経済である上、却って皮膚の炎症を誘発してしまう虞れがあるので好ましくない。 Examples of antiseptics (antibacterial / bactericidal agents) include urea, methyl paraoxybenzoate (methyl paraben), ethyl paraoxybenzoate (ethyl paraben), propyl paraoxybenzoate (propyl paraben), butyl paraoxybenzoate (butyl parabe), and the like. Paraoxybenzoates, phenoxyethanol, dichlorophen, hexachlorophene, chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazolidene urea), 1,2-pentanediol, various essential oils A bark dry product and the like can be preferably used. In addition, among these antiseptic / bactericides, parabens such as methylparaben, ethylparaben, propylparaben, and butylparaben are used alone or in admixture of two or more to effectively prevent spoilage by adding a small amount. This is preferable because it can be performed. Although the addition amount in the case of using parabens as a preservative is not specifically limited, It is preferable to add 0.1-10 mass% in total, and it is more preferable to add 0.5-5 mass%. If the addition amount of the parabens is less than 0.1% by mass, a sufficient anti-corruption effect cannot be obtained. On the contrary, if the addition amount of the parabens exceeds 10% by mass, it is uneconomical. On the other hand, it is not preferable because it may cause skin inflammation.
粉体成分としては、たとえば、セリサイト、酸化チタン、タルク、カオリン、ベントナイト、酸化亜鉛、炭酸マグネシウム、酸化マグネシウム、酸化ジルコニウム、硫酸バリウム、無水ケイ酸、雲母、ナイロンパウダー、ポリエチレンパウダー、シルクパウダー、セルロース系パウダー、穀類（米、麦、トウモロコシ、キビ等）のパウダー、豆類（大豆、小豆等）のパウダー等を好適に用いることができる。 Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, Cellulose powder, grains (rice, wheat, corn, millet, etc.) powder, beans (soybean, red beans, etc.) powder, and the like can be suitably used.
紫外線吸収剤としては、たとえば、パラアミノ安息香酸エチル、パラジメチルアミノ安息香酸エチルヘキシル、サリチル酸アミルおよびその誘導体、パラメトキシ桂皮酸２−エチルヘキシル、桂皮酸オクチル、オキシベンゾン、２，４−ジヒドロキシベンゾフェノン、２−ヒドロキシ−４−メトキシベンゾフェノン−５−スルホン酸塩、４−ターシャリーブチル−４−メトキシベンゾイルメタン、２−（２−ヒドロキシ−５−メチルフェニル）ベンゾトリアゾール、ウロカニン酸、ウロカニン酸エチル、アロエ抽出物等を好適に用いることができる。 Examples of the UV absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy- 4-methoxybenzophenone-5-sulfonate, 4-tertiarybutyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. It can be used suitably.
抗酸化剤としては、たとえば、ブチルヒドロキシアニソール、ブチルヒドロキシトルエン、没食子酸プロピル、ビタミンＥおよびその誘導体、ビャッキュウ抽出物、イネ抽出物等を好適に用いることができる。 As the antioxidant, for example, butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives, beech extract, rice extract and the like can be suitably used.
さらに、本発明に係るスキンケア用ローションには、必要に応じて、ヒアルロン酸（特に高分子ヒアルロン酸）等の保湿剤（水分調整剤）等を添加することも可能である。なお、ヒアルロン酸を添加する場合には、その添加量は特に限定されないが、０．００５〜５質量％であると、皮膚の保湿性および経済性の観点から好ましく、０．０５〜３質量％であるとより好ましい。加えて、ヒアルロン酸を添加する場合には、高分子ヒアルロン酸とヒアルロン酸ナトリウムとを混合して用いるのが好ましく、その混合比が、３０重量部：７０重量部〜７０重量部：３０重量部の範囲内にあると、より好ましい。 Furthermore, a moisturizing agent (moisture adjusting agent) such as hyaluronic acid (particularly high-molecular hyaluronic acid) or the like can be added to the skin care lotion according to the present invention as necessary. In addition, when adding hyaluronic acid, the addition amount is not particularly limited, but 0.005 to 5% by mass is preferable from the viewpoint of skin moisture retention and economy, and 0.05 to 3% by mass. Is more preferable. In addition, when adding hyaluronic acid, it is preferable to use a mixture of polymeric hyaluronic acid and sodium hyaluronate, and the mixing ratio is 30 parts by weight: 70 parts by weight to 70 parts by weight: 30 parts by weight. It is more preferable that it is within the range.
加えて、本発明に係るスキンケア用ローションに、フコイダン（硫酸多糖の一種であり、昆布、ワカメ等の褐藻類の粘質物に多く含まれる食物繊維、海藻エキス）を添加すると、抗菌作用によってシワ・シミ取り作用、美肌化・美白化作用、日焼け防止効果、皮膚炎改善効果が一段と良好なものとなるので好ましい。フコイダンの添加量は、特に限定されないが、０．００５〜５質量％であると、シワ・シミ取り作用、美肌化・美白化作用、日焼け防止効果、皮膚炎改善効果および経済性の観点から好ましく、０．０５〜２質量％であるとより好ましい。 In addition, fucoidan (a dietary fiber and seaweed extract, which is a kind of sulfated polysaccharide, and is abundant in brown algae mucilage such as kelp and seaweed) is added to the skin care lotion according to the present invention. It is preferable because the stain removing action, skin beautification / whitening action, sunburn preventing effect, and dermatitis improving effect are further improved. The amount of fucoidan added is not particularly limited, but it is preferably 0.005 to 5% by mass from the viewpoints of wrinkle / smear removing action, skin beautification / whitening action, sunburn preventing effect, dermatitis improving effect and economic efficiency. 0.05 to 2% by mass is more preferable.
さらに、本発明に係る化粧料には、抗菌成分として重金属イオンを含有させるのが好ましい。かかる重金属イオンとしては、各種のものを用いることができるが、銀イオン、亜鉛イオン、チタンイオン、あるいはそれらの内の１種、または２種以上を混合してなるものであると、高いシワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果が得られるので好ましい。加えて、銀イオン、亜鉛イオン、チタンイオンの複合金属イオンを用いると、シワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果が一層良好なものとなるのでより好ましい。重金属イオンの含有量は、特に限定されないが、０．１〜１０質量％含有させるのが好ましく、０．５〜５質量％含有させるのがより好ましい。重金属イオンの含有量が、上記した範囲を下回ると、十分なシワ・シミ取り効果、美肌化・美白化効果、日焼け防止効果、皮膚炎改善効果が得られないので好ましくなく、重金属イオンの含有量が、上記した範囲を上回ると、不経済である上、却って皮膚の炎症を誘発してしまう虞れがあるので好ましくない。 Furthermore, the cosmetic according to the present invention preferably contains heavy metal ions as an antibacterial component. As such heavy metal ions, various types of ions can be used. Silver ions, zinc ions, titanium ions, or one of them, or a mixture of two or more thereof can be highly wrinkled. This is preferable because it is effective in removing stains, making skin beautiful and whitening, preventing sunburn, and improving dermatitis. In addition, it is more preferable to use a composite metal ion of silver ion, zinc ion and titanium ion because the wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect and dermatitis improvement effect will be even better. . The content of heavy metal ions is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass. If the content of heavy metal ions is below the above range, it is not preferable because sufficient wrinkle / stain removal effect, skin beautification / whitening effect, sun protection effect, dermatitis improvement effect cannot be obtained, and content of heavy metal ions However, if it exceeds the above range, it is not preferable because it is uneconomical and may induce skin irritation.
なお、本発明に係るスキンケア用ローションの製造に当たっては、製造方法は特に限定されるものではないが、必要に応じて、原料あるいは原料の混合液を、３０℃〜１００℃の温度範囲内で加熱するのが好ましい。 In the production of the skin care lotion according to the present invention, the production method is not particularly limited, but if necessary, the raw material or a mixed liquid of the raw materials is heated within a temperature range of 30 ° C to 100 ° C. It is preferable to do this.
以下、実施例によって本発明に係るスキンケア用ローションについてより詳細に説明するが、本発明は、かかる実施例の態様に何ら限定されるものではなく、本発明の趣旨を逸脱しない範囲で、適宜変更することが可能である。また、実施例における物性、特性の評価方法は以下の通りである。なお、下記の各官能評価においては、被験者３名分の各評価結果の平均的な段階（○，△，×）を最終的な評価結果とした。 Hereinafter, the skin care lotion according to the present invention will be described in more detail with reference to examples. However, the present invention is not limited to the embodiments of the examples, and may be appropriately changed without departing from the spirit of the present invention. Is possible. Moreover, the evaluation methods of physical properties and characteristics in the examples are as follows. In the following sensory evaluation, the average stage (◯, Δ, ×) of the evaluation results for the three subjects was used as the final evaluation result.
＜シワ取り・シミ取り効果＞
各実施例および比較例で調製されたスキンケア用ローションを、以下の（１）〜（４）の方法で３名の被験者（いずれも５０代）に使用し、当該使用を一定期間（１週間）に亘って繰り返した。
（１）所定量（約５．０ｇ）のスキンケア用ローションの顔面への塗布（手による塗布）
（２）皮膚への十分な擦り込み
（３）約１０時間に亘る保持
（４）市販の石鹸を用いた先願による除去
そして、上記の如くスキンケア用ローションの使用を繰り返した後の各被験者の顔面の皮膚の状態を、下記の４段階で官能評価した。
○：目尻や額のシワや皮膚のシミに十分な軽減効果が見られる。
△：目尻や額のシワや皮膚のシミに僅かな軽減効果が見られる。
×：目尻や額のシワや皮膚のシミにほとんど軽減効果が見られない。
<Wrinkle removal and stain removal effect>
The skin care lotion prepared in each example and comparative example was used for 3 subjects (all in their 50s) by the following methods (1) to (4), and the use was performed for a certain period (1 week). It repeated over.
(1) Applying a predetermined amount (about 5.0g) of skin care lotion to the face (application by hand)
(2) Sufficient rubbing into skin (3) Holding for about 10 hours (4) Removal by prior application using commercially available soap And the face of each subject after repeated use of skin care lotion as described above The skin condition of was subjected to sensory evaluation in the following four stages.
○: A sufficient reduction effect is observed in the corners of the eyes, wrinkles on the forehead and skin spots.
Δ: Slight reduction effect is observed in the corners of the eyes, wrinkles of the forehead and skin spots.
×: Almost alleviating effect is not seen in the corners of the eyes, wrinkles of the forehead and skin spots
＜美白効果＞
各実施例および比較例で調製されたスキンケア用ローションの使用（上記（１）〜（４）の方法による使用）を一定期間に亘って繰り返した後の各被験者の顔面の皮膚の色の変化を、下記の４段階で官能評価した。
○：顔全体の皮膚に十分な白色化が認められる。
△：顔全体の皮膚に僅かな白色化が認められる。
×：顔全体の皮膚に白色化が認められない。
<Whitening effect>
Changes in skin color on the face of each subject after repeating the use of the skin care lotion prepared in each Example and Comparative Example (use by the method of (1) to (4) above) over a certain period of time The sensory evaluation was performed in the following four stages.
○: Sufficient whitening is observed on the skin of the entire face.
(Triangle | delta): Slight whitening is recognized by the skin of the whole face.
X: Whitening is not recognized in the skin of the whole face.
＜日焼け防止効果＞
各実施例および比較例で調製されたスキンケア用ローションを、所定量（約０．０４ｇ／ｃｍ２）だけ顔面の一部（片側の頬）に塗布した後、所定時間（約５時間）に亘って顔面を太陽光に曝し、しかる後、スキンケア用ローションを塗布した部分と塗布しなかった部分とを目視して、日焼け状態を下記の３段階で官能評価した。
○：スキンケア用ローションの塗布部分の日焼け状態と非塗布部分の日焼け状態とに明確な差（色の違い）が見られた。
△：スキンケア用ローションの塗布部分の日焼け状態と非塗布部分の日焼け状態とに若干の差が見られた。
×：スキンケア用ローションの塗布部分の日焼け状態と非塗布部分の日焼け状態とに差が見られなかった。
<Anti-sun effect>
The skin care lotion prepared in each example and comparative example was applied to a part of the face (one side cheek) by a predetermined amount (about 0.04 g / cm 2 ), and then for a predetermined time (about 5 hours). Then, the face was exposed to sunlight, and then the part where the skin care lotion was applied and the part where the skin care lotion was not applied were visually observed, and the tanned state was subjected to sensory evaluation in the following three stages.
○: A clear difference (color difference) was observed between the tanned state of the application part of the skin care lotion and the tanned state of the non-application part.
(Triangle | delta): Some difference was looked at by the sunburn state of the application part of the lotion for skin care, and the sunburn state of the non-application part.
X: No difference was found between the tanned state of the application part of the skin care lotion and the tanned state of the non-application part.
＜皮膚炎の改善効果＞
各実施例および比較例で調製されたスキンケア用ローションを、アトピー性皮膚炎の疾患を有する治験者に対して、一定期間に亘って繰り返し使用した（約一週間に亘って１日２回、炎症の激しい部分に十分に塗布した）。しかる後、アトピー性皮膚炎の改善状態を、目視によって下記の４段階で官能評価した。
○：患部の症状に著しい改善効果が見られた。
△：患部の症状に若干の改善効果が見られた。
×：患部の症状に改善効果が見られなかった。
<Improvement effect of dermatitis>
The skin care lotion prepared in each example and comparative example was used repeatedly over a period of time for investigators with atopic dermatitis disease (inflammation twice a day for approximately one week). It was applied enough to the intense part). Thereafter, sensory evaluation of the improved state of atopic dermatitis was visually performed in the following four stages.
○: Significant improvement effect was observed in the symptoms of the affected area.
(Triangle | delta): Some improvement effect was seen by the symptom of the affected part.
X: The improvement effect was not seen in the symptom of the affected part.
＜スキンケア用ローションの臭い＞
上記の如きスキンケア用ローションの使用を一定期間に亘って繰り返した際に被験者が感じた臭いを下記の３段階で官能評価した。
○：特に悪臭を感じない。
△：若干の悪臭を感じる。
×：悪臭を感じる。
<Odor of skincare lotion>
The odor felt by the subject when the use of the skin care lotion as described above was repeated over a certain period of time was sensory evaluated in the following three stages.
○: No particular bad odor is felt.
Δ: A slight odor is felt.
X: A bad smell is felt.
［実施例１］
＜スキンケア用ローションの調製＞
下記の各成分を混合することによって、実施例１のスキンケア用ローションを得た。すなわち、約８０℃に加熱した精製水中に、アミノ酸（Ｌ−システイン（塩酸塩）、Ｌ−アルギニン、Ｌ−リジン（塩酸塩））を混合して攪拌する一方（溶液Ａ）、プロポリス、ブチルグリコール、グリセリンを混合して攪拌した（溶液Ｂ）。しかる後、溶液Ａ，Ｂと植物エキスとフコイダンとを混合して攪拌し、混合液を約７０℃まで再加熱した後、常温まで冷却し、ヒアルロン酸、香料、防腐剤を混合して攪拌することによって、実施例１のスキンケア用ローションを得た。
＜スキンケア用ローションの成分＞
・プロポリス溶液（２０質量％抽出液（エタノール溶液））：１．０質量％（プロポリスの純成分の濃度＝０．２質量％）
・ブチルグリコール：５．０質量％
・グリセリン：７９．８質量％
・香料：０．２質量％
・フコイダン（海藻エキス）：３．０質量％
・植物エキス（１．０質量％）
・クララ葉エキス：０．２質量％
・ショウガ根エキス：０．２質量％
・センキュウエキス：０．２質量％
・トウキエキス：０．２質量％
・オタネニンジン根エキス：０．２質量％
・アミノ酸（２．１質量％）
・Ｌ−システイン（塩酸塩）：０．７質量％
・Ｌ−アルギニン： ０．７質量％
・Ｌ−リシン（塩酸塩）：０．７質量％
・ヒアルロン酸（高分子ヒアルロン酸とヒアルロン酸ナトリウムとを重量比１：１で混合したもの）：３．０質量％
・防腐剤（０．１質量％）
・メチルパラベン：０．０２５質量％
・エチルパラベン： ０．０２５質量％
・プロピルパラベン：０．０２５質量％
・ブチルパラベン：０．０２５質量％
・精製水：残余量
[Example 1]
<Preparation of skin care lotion>
The skin care lotion of Example 1 was obtained by mixing the following components. In other words, amino acids (L-cysteine (hydrochloride), L-arginine, L-lysine (hydrochloride)) are mixed and stirred in purified water heated to about 80 ° C. (solution A), propolis, butyl glycol The glycerin was mixed and stirred (solution B). Thereafter, the solutions A and B, the plant extract and fucoidan are mixed and stirred, and the mixture is reheated to about 70 ° C., then cooled to room temperature, and hyaluronic acid, a fragrance, and a preservative are mixed and stirred. Thus, a skin care lotion of Example 1 was obtained.
<Ingredients for skin care lotion>
Propolis solution (20% by mass extract (ethanol solution)): 1.0% by mass (concentration of pure components of propolis = 0.2% by mass)
・ Butyl glycol: 5.0% by mass
・ Glycerin: 79.8% by mass
-Fragrance: 0.2% by mass
-Fucoidan (seaweed extract): 3.0% by mass
・ Plant extract (1.0% by mass)
・ Clara leaf extract: 0.2% by mass
・ Ginger root extract: 0.2% by mass
-Senkyu extract: 0.2% by mass
・ Touki extract: 0.2% by mass
・ Ginseng root extract: 0.2% by mass
・ Amino acid (2.1% by mass)
L-cysteine (hydrochloride): 0.7% by mass
L-arginine: 0.7% by mass
L-lysine (hydrochloride): 0.7% by mass
Hyaluronic acid (a mixture of high-molecular hyaluronic acid and sodium hyaluronate in a weight ratio of 1: 1): 3.0% by mass
・ Preservative (0.1% by mass)
・ Methylparaben: 0.025% by mass
・ Ethylparaben: 0.025% by mass
・ Propylparaben: 0.025% by mass
・ Butylparaben: 0.025 mass%
・ Purified water: remaining amount
しかる後、上記した方法で３名の被験者に対してスキンケア用ローションを使用し、上記した「シワ取り・シミ取り効果」、「美白効果」、「日焼け防止効果」、「皮膚炎の改善効果」および「スキンケア用ローションの臭い」の４項目について評価した。評価結果をスキンケア用ローションの組成とともに表１に示す。 After that, using the skin care lotion for the three subjects by the above method, the above-mentioned “wrinkle removal / smear removal effect”, “whitening effect”, “sunburn prevention effect”, “dermatitis improvement effect” And four items of “smelling skin care lotion” were evaluated. The evaluation results are shown in Table 1 together with the composition of the skin care lotion.
［実施例２〜４］
スキンケア用ローションを調製する際に、添加するアミノ酸を、それぞれ、Ｌ−システインのみ、Ｌ−アルギニンのみ、Ｌ−リシン（塩酸塩）のみとするとともに、それらの混合割合を３．０質量％に変更した（その変更に合わせて残余の精製水の量も変更した）以外は、実施例１のスキンケア用ローションの調製と同様にして、実施例２〜４のスキンケア用ローションを調製した。そして、それらの実施例２〜４のスキンケア用ローションを、実施例１と同様な方法で、被験者に使用した後に、実施例１と同様に評価した。評価結果をスキンケア用ローションの組成とともに表１に示す。
[Examples 2 to 4]
When preparing a skin care lotion, the amino acids to be added are L-cysteine only, L-arginine only, and L-lysine (hydrochloride), respectively, and the mixing ratio thereof is changed to 3.0% by mass. The skin care lotions of Examples 2 to 4 were prepared in the same manner as the preparation of the skin care lotion of Example 1 except that the amount of the remaining purified water was changed according to the change. Then, the skin care lotions of Examples 2 to 4 were evaluated in the same manner as in Example 1 after being used for subjects in the same manner as in Example 1. The evaluation results are shown in Table 1 together with the composition of the skin care lotion.
［実施例５〜８］
スキンケア用ローションを調製する際に、プロポリスの混合割合（プロポリスの純成分の濃度）を、それぞれ、０．０２５質量％、０．２５質量％、０．５質量％、２．５質量％に変更した（すなわち、プロポリスの純成分の濃度を、それぞれ、０．００５質量％、０．０５質量％、０．１質量％、０．５質量％に変更し、その変更に合わせて残余の精製水の量も変更した）以外は、実施例１のスキンケア用ローションの調製と同様にして、実施例５〜８のスキンケア用ローションを調製した。そして、それらの実施例５〜８のスキンケア用ローションを、実施例１と同様な方法で、被験者に使用した後に、実施例１と同様に評価した。評価結果をスキンケア用ローションの組成とともに表１に示す。
[Examples 5 to 8]
When preparing a lotion for skin care, the mixing ratio of propolis (concentration of pure components of propolis) was changed to 0.025 mass%, 0.25 mass%, 0.5 mass%, and 2.5 mass%, respectively. (That is, the concentration of the pure component of propolis was changed to 0.005% by mass, 0.05% by mass, 0.1% by mass, and 0.5% by mass, respectively, and the remaining purified water was adjusted accordingly. The skin care lotions of Examples 5 to 8 were prepared in the same manner as in the preparation of the skin care lotion of Example 1, except that the amount of was changed. Then, the skin care lotions of Examples 5 to 8 were evaluated in the same manner as in Example 1 after being used for subjects in the same manner as in Example 1. The evaluation results are shown in Table 1 together with the composition of the skin care lotion.
［実施例９〜１１］
スキンケア用ローションを調製する際に、それぞれ、植物エキス、ヒアルロン酸、フコイダンを添加しなかった（それらの分だけ残余の精製水の量を増加させた）以外は、実施例１のスキンケア用ローションの調製と同様にして、実施例９〜１１のスキンケア用ローションを調製した。そして、それらの実施例９〜１１のスキンケア用ローションを、実施例１と同様な方法で、被験者に使用した後に、実施例１と同様に評価した。評価結果をスキンケア用ローションの組成とともに表１に示す。
[Examples 9 to 11]
When the skin care lotion was prepared, the plant extract, hyaluronic acid and fucoidan were not added (the amount of the remaining purified water was increased by those amounts), respectively. In the same manner as the preparation, skin care lotions of Examples 9 to 11 were prepared. And after using those skin care lotions of Examples 9 to 11 in the same manner as in Example 1, they were evaluated in the same manner as in Example 1. The evaluation results are shown in Table 1 together with the composition of the skin care lotion.
＜比較例１＞
スキンケア用ローションを調製する際に、プロポリスを添加しなかった（その分だけ残余の精製水の量を増加させた）以外は、実施例１のスキンケア用ローションの調製と同様にして、比較例１のスキンケア用ローションを調製した。そして、その比較例１のスキンケア用ローションを、実施例１と同様な方法で、被験者に使用した後に、実施例１と同様に評価した。評価結果をスキンケア用ローションの組成とともに表１に示す。
<Comparative Example 1>
Comparative Example 1 was carried out in the same manner as in the preparation of the skin care lotion of Example 1, except that no propolis was added (the amount of the remaining purified water was increased by that amount) when preparing the skin care lotion. A lotion for skin care was prepared. Then, the skin care lotion of Comparative Example 1 was evaluated in the same manner as in Example 1 after being used for the subject in the same manner as in Example 1. The evaluation results are shown in Table 1 together with the composition of the skin care lotion.
＜比較例２＞
スキンケア用ローションを調製する際に、アミノ酸を添加しなかった（その分だけ残余の精製水の量を増加させた）以外は、実施例１のスキンケア用ローションの調製と同様にして、比較例２のスキンケア用ローションを調製した。そして、その比較例２のスキンケア用ローションを、実施例１と同様な方法で、被験者に使用した後に、実施例１と同様に評価した。評価結果をスキンケア用ローションの組成とともに表１に示す。
<Comparative Example 2>
Comparative Example 2 was carried out in the same manner as in the preparation of the skin care lotion of Example 1, except that no amino acid was added (the amount of the remaining purified water was increased by that amount) when preparing the skin care lotion. A lotion for skin care was prepared. Then, the skin care lotion of Comparative Example 2 was evaluated in the same manner as in Example 1 after being used for the subject in the same manner as in Example 1. The evaluation results are shown in Table 1 together with the composition of the skin care lotion.
表１から、プロポリスおよびアミノ酸を含有する実施例１〜１１のスキンケア用ローションを被験者に使用した場合には、シワ取り・シミ取り効果、美白効果ともに良好で、日焼け防止効果および皮膚炎の改善効果があり、その上、使用時にスキンケア用ローションの臭いが気にならないことが分かる。これに対して、プロポリスあるいはアミノ酸を含有していない比較例１，２のスキンケア用ローションを使用した場合には、良好なシワ取り・シミ取り効果、美白効果が得られなかったり、日焼け防止効果や皮膚炎の改善効果が得られたかったりすることが分かる。 From Table 1, when the skin care lotions of Examples 1 to 11 containing propolis and amino acids were used for the test subjects, both the wrinkle removal / stain removal effect and the whitening effect were good, the sun protection effect and the dermatitis improvement effect In addition, it can be seen that the odor of the skin care lotion does not matter when used. On the other hand, when using the skin care lotion of Comparative Examples 1 and 2 that does not contain propolis or amino acids, good wrinkle removal / stain removal effect, whitening effect cannot be obtained, sunburn prevention effect, It turns out that the improvement effect of dermatitis is desired.
本発明に係るスキンケア用ローションは、上記の如く優れた効果を奏するものであるので、シワ・シミ取り、美白化、日焼け防止、皮膚炎の症状改善のためのスキンクリーム、化粧水、乳液等の各種のスキンケア用ローションとして、好適に用いることができる。 Since the skin care lotion according to the present invention has excellent effects as described above, it is suitable for removing wrinkles and stains, whitening, preventing sunburn, skin cream for improving symptoms of dermatitis, lotion, emulsion and the like. It can be suitably used as various skin care lotions.
Claims (5)
プロポリスおよびアミノ酸を含有することを特徴とするスキンケア用ローション。 It is a lotion such as cream, lotion, milky lotion used for skin care,
A skin care lotion characterized by containing a propolis and an amino acid.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115317425A (en) * | 2022-09-02 | 2022-11-11 | 广东丸美生物技术股份有限公司 | Eye essence and preparation method thereof |
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| JPS6431707A (en) * | 1987-07-28 | 1989-02-02 | Nikko Chemicals | Dermal agent for external use |
| JP2009232817A (en) * | 2008-03-28 | 2009-10-15 | Api Co Ltd | Propolis composition and method for producing the same |
| WO2015107703A1 (en) * | 2014-01-15 | 2015-07-23 | 相互 秋田 | Chemical composition |
| JP2015214511A (en) * | 2014-05-09 | 2015-12-03 | 相互 秋田 | Chemical composition |
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| JPS59118702A (en) * | 1982-12-25 | 1984-07-09 | Shiseido Co Ltd | Cosmetic |
| JPS6431707A (en) * | 1987-07-28 | 1989-02-02 | Nikko Chemicals | Dermal agent for external use |
| JP2009232817A (en) * | 2008-03-28 | 2009-10-15 | Api Co Ltd | Propolis composition and method for producing the same |
| WO2015107703A1 (en) * | 2014-01-15 | 2015-07-23 | 相互 秋田 | Chemical composition |
| JP2015214511A (en) * | 2014-05-09 | 2015-12-03 | 相互 秋田 | Chemical composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115317425A (en) * | 2022-09-02 | 2022-11-11 | 广东丸美生物技术股份有限公司 | Eye essence and preparation method thereof |
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