JP2013253021A - Sterilization-disinfection agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an iodine base compound-including sterilization-disinfection agent in which the reduction of iodine is suppressed, the sterilization-disinfection effect of iodine is not reduced, and further, gel-shaped form is retained.SOLUTION: A sterilization-disinfection agent includes: an iodine base compound; a copolymer including acryloyldimethyltaurate monomers in the constituent unit of polymerization; and lower alcohol.

Description

  The present invention relates to an antibacterial disinfectant containing an iodine compound that suppresses reduction of iodine and maintains a gel-like form without reducing the disinfection / disinfection effect of iodine.

Iodine-based compounds contain excellent bactericidal compounds that exhibit a bactericidal and disinfecting effect by oxidizing action, and are widely used for hand disinfection, gargles, topical bactericidal disinfectants and the like. Povidone iodine, a representative iodine-based bactericidal compound, is a complex of 1-vinyl-2-pyrrolidone polymer (polyvinylpyrrolidone) and iodine, and its oxidizing action by free iodine can be used for various bacteria, fungi, viruses, etc. It exhibits a quick disinfection effect against a wide range of microorganisms.
As for povidone iodine, a solution of about 0.1 to 7.5 w / v% is used for washing and disinfecting fingers and skin, and a solution of about 10 w / v% is used for disinfecting burned skin surface and infected skin surface. It is a very useful disinfectant.

When the iodine compound is diluted with alcohol having both bactericidal and volatile properties, drying of the bactericidal disinfectant can be promoted moderately, and it is not necessary to wipe off with a towel. Moreover, the sterilization effect of iodine can be stabilized for a long time.
However, when using an alcohol solution of iodine compound, the solution is applied to the surface to be disinfected by spraying it on the palm, but the liquid flows easily like water and spills, flows or scatters from the palm. However, due to its volatility, it is difficult to apply or wear the fingers in a uniform state, and there is a risk of ignition.

  Therefore, in order to reduce the complexity of handling the alcohol solution, the alcohol solution is mixed with a carboxyvinyl polymer or a cellulose-based water-soluble polymer compound to increase the viscosity. A gel-like disinfectant that can be held on the surface has been proposed (see, for example, Patent Document 1).

JP-A-6-199700

  However, in the germicidal disinfectant containing a gel-like iodine compound using a highly versatile carboxyvinyl polymer as a thickener, the carboxyvinyl polymer is acidic, so this is used for thickening the iodine compound. It is necessary to neutralize with basic sodium hydroxide, diisopropanolamine or the like. At this time, the iodine of the iodine compound was reduced by the oxidation-reduction reaction, and there was a problem that the sterilizing and disinfecting effect was impaired.

  In addition, when only a cellulose-based water-soluble polymer compound is used as a thickening agent, as described in Patent Document 1, it is difficult to spread over the entire finger due to poor elongation, and there is a strong sticky feeling before and after drying. There are drawbacks. For this reason, the cellulose-based water-soluble polymer compound must be used in combination with a carboxyvinyl polymer. In this case, it is necessary to neutralize with a basic substance, which causes the above-mentioned problems.

  The present invention provides an antibacterial disinfectant containing an iodine compound that suppresses the reduction of iodine and maintains the gel-like form without reducing the disinfecting effect of iodine.

The disinfectant according to the present invention is
An iodine compound,
A copolymer containing acryloyldimethyltaurate monomer as a constituent unit of the polymerization;
Lower alcohol,
including.

According to the disinfectant of the present invention, since a copolymer containing acryloyldimethyltaurate monomer as a thickening agent is used as a thickening agent, it is possible to obtain a feeling of use with good stretch and no stickiness.
Furthermore, since it can be made into a gel without adjusting pH such as neutralization, even when used for thickening an iodine compound, the reduction of iodine is suppressed and the bactericidal disinfection effect is maintained.

  The disinfectant of the present invention includes an iodine compound, a copolymer containing an acryloyldimethyl taurate monomer as a constituent unit for polymerization, and a lower alcohol.

Examples of iodine compounds having a bactericidal and disinfecting effect applicable to the present invention include iodo tincture, povidone iodine, iodoform, and the like, and povidone iodine is exemplified below.
The content of povidone iodine is not particularly limited, but is preferably 0.1 to 3.0 w / v%.

In addition, a copolymer containing acryloyldimethyltaurate monomer applicable to the present invention as a thickener in the structural unit of polymerization is partially or completely neutralized and can be used in a wide pH range. There is no particular limitation as long as viscosity can be imparted in a small amount without the need for sum.
Specifically, Aristoflex AVC (acryloyl dimethyl taurine ammonium / vinyl pyrrolidone (VP) copolymer), Aristoflex HMB (acryloyl dimethyl taurine ammonium / sold by the brand name Aristoflex, sold by Clariant (Germany). (Beheneth-25 methacrylate polymer), Aristoflex AVC-1 (acryloyldimethyltaurine ammonium / vinylformamide copolymer), Aristoflex SNC (acryloyldimethyltauronium ammonium / stealesmethacrylate-8 copolymer) and the like.
Aristoflex can be thickened in the low pH region without being neutralized, and is not sticky and can be characterized by a light touch.

  The content of the thickener is not particularly limited, but it is required that the disinfectant is easily spread and used in a uniform state during use, and that there is no spillage, stickiness, or residual feeling from the hands. Taking these into consideration, it is preferably 0.1 to 2.0 w / v%.

As a solvent for these bactericidal compounds and thickeners, lower alcohols such as ethanol and 2-propanol can be used. Lower alcohol can moderately accelerate the drying of the disinfectant due to its volatility. Moreover, the bactericidal power of iodine can be maintained and stabilized.
The lower alcohol further functions not only as a solvent but also as a compound having bactericidal properties.

The content of the lower alcohol is not particularly limited, but is preferably 40.0 to 90.0 v / v%. When it is less than 40.0 v / v%, the drying speed after use is slow. And when it exceeds 90.0 v / v%, skin irritation occurs. Therefore, it is not preferable in any case.
Water can be added to adjust the lower alcohol concentration.

  For the purpose of enhancing the functionality of the sterilizing and disinfecting agent of the present invention, a moisturizing agent, a coloring agent, a flavoring agent, a deodorizing agent, a stabilizer and the like can be appropriately added.

  Conventionally, a gel-like disinfectant containing an iodine compound as a disinfectant compound has lost its disinfectant effect due to the basic substance added for neutralization. However, the copolymer containing the acryloyldimethyl taurate monomer used in the disinfectant of the present invention as a structural unit of polymerization is a partially neutralized pre-neutralized type, and has a pH value to increase viscosity. No adjustment is required. Therefore, according to the present invention, even if an iodine-based compound that exhibits a bactericidal and disinfecting effect due to an oxidizing action such as povidone iodine is included, iodine is not reduced, so that a disinfecting agent that maintains the bactericidal and disinfecting effect is provided. it can.

  The gel-like iodine-based compound-containing disinfectant of the present invention having the above composition does not spill or flow from the palm. It was found that the sterilizing effect can be exhibited while being kept in a uniform state.

  Further, since the alcohol contained therein is volatile, the disinfectant is easily dried naturally after being uniformly applied and worn on the surface of the hand. Therefore, it can be used even in a place where there is no washing water, and after use, there is no need to wipe off with a towel or the like, and there is no stickiness. Also, there is a low risk of scattering and igniting during use.

  Furthermore, by changing the concentration of the thickener as appropriate, the viscosity of the sterilizing and disinfecting agent can be changed. For example, it can be put in a tube container or a dropper container to improve portability.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in more detail, this invention is not limited only to the Example which concerns.

  According to the composition described below, each sample of Example 1 and Example 2 and Comparative Example 1 and Comparative Example 2 was prepared, and a disinfectant was obtained.

Example 1
Povidone iodine 0.5 w / v%
Aristoflex AVC 1.0 w / v%
Ethanol 83.0v / v%
Purified water balance The bactericidal disinfectant obtained by the above composition was in the form of a gel, did not feel sticky, and did not spill or flow from the palm. Since the color tone is reddish brown, the reduction of iodine is suppressed, indicating that the sterilizing effect is maintained.

Example 2
Povidone iodine 0.5 w / v%
Aristoflex HMB 1.0 w / v%
Ethanol 83.0v / v%
Purified water balance The bactericidal disinfectant obtained by the above composition was in the form of a gel, did not feel sticky, and did not spill or flow from the palm. Since the color tone is reddish brown, the reduction of iodine is suppressed, indicating that the sterilizing effect is maintained.

Comparative Example 1
Povidone iodine 0.5 w / v%
Ethanol 83.0v / v%
Purified water remainder The disinfectant obtained by the above composition has a reddish brown color, indicating that the reduction of iodine is suppressed and maintains the disinfectant effect, but it contains a thickener. There was no gel, so it spilled or flowed from the palm.

Comparative Example 2
Povidone iodine 0.5 w / v%
Carboxyvinyl polymer 1.0 w / v%
Diisopropanolamine 0.5 w / v%
Ethanol 83.0v / v%
Purified water balance The bactericidal disinfectant obtained by the above composition was in the form of a gel, did not feel sticky, and did not spill or flow from the palm. However, since the color tone is colorless and transparent, it is shown that iodine is reduced and the sterilizing effect is impaired.

  INDUSTRIAL APPLICABILITY The present invention is useful as an antibacterial disinfectant containing an iodine compound that suppresses the reduction of iodine and does not reduce the disinfection / disinfection effect of iodine and maintains a gel-like form.

Claims (7)

An iodine compound,
A copolymer containing acryloyldimethyltaurate monomer as a constituent unit of the polymerization;
Lower alcohol,
Disinfectant containing.   The copolymers include: acryloyl dimethyl taurine ammonium / vinyl pyrrolidone (VP) copolymer, acryloyl dimethyl taurine ammonium / beheneth methacrylate cross-polymer, acryloyl dimethyl taurine ammonium / vinyl formamide copolymer, and acryloyl dimethyl taurine ammonium / steare methacrylate-8 copolymer. The disinfectant according to claim 1, which is at least one selected from the group consisting of:   The disinfectant according to claim 1 or 2, wherein the content of the copolymer is 0.1 to 2.0 w / v% in the total amount of the disinfectant.   The disinfectant according to any one of claims 1 to 3, wherein the content of the iodine compound is 0.1 to 3.0 w / v% in the total amount of the disinfectant.   The disinfectant according to any one of claims 1 to 4, wherein the content of the lower alcohol is 40.0 to 90.0 v / v% in the total amount of the disinfectant.   The disinfectant according to any one of claims 1 to 5, wherein the iodine compound is povidone iodine.   The disinfectant according to any one of claims 1 to 6, wherein the lower alcohol is ethanol.