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CN111838177A - Preparation method and preparation system of gel disinfectant - Google Patents

Preparation method and preparation system of gel disinfectant Download PDF

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CN111838177A
CN111838177A CN202010876017.9A CN202010876017A CN111838177A CN 111838177 A CN111838177 A CN 111838177A CN 202010876017 A CN202010876017 A CN 202010876017A CN 111838177 A CN111838177 A CN 111838177A
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gel
disinfectant
gel disinfectant
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刘群峰
于珊
耿志杰
裴大婷
国翠平
鲁道欢
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GUANGDONG INSTITUTE OF MEDICAL INSTRUMENTS
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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    • AHUMAN NECESSITIES
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    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/20Elemental chlorine; Inorganic compounds releasing chlorine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

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Abstract

The invention discloses a preparation method and a preparation system of a gel disinfectant, and relates to the technical field of preparation of gel disinfectants. The preparation method of the gel disinfectant comprises the steps of mixing acidic oxidation potential water, a stabilizing agent and a buffering agent to prepare a mixed solution; adding a gelling agent into the mixed solution while stirring to obtain a gel disinfectant; wherein the stabilizer comprises cyclodextrin, silicon dioxide and polyvinylpyrrolidone. The method can rapidly prepare the stable gel disinfectant by mixing the acidic electrolyzed oxidizing water with the compounded stabilizer and the buffering agent, so that the gel disinfectant has the effect of stable storage, the quality guarantee period of the gel disinfectant is prolonged, and the long-distance transportation and long-term storage are facilitated. The preparation system can rapidly prepare the gel disinfectant through the connection and matching of the electrolysis device and the synthesis device, has high synthesis efficiency, and can obtain the gel disinfectant which has longer quality guarantee period and is friendly to skin tissues.

Description

Preparation method and preparation system of gel disinfectant
Technical Field
The invention relates to the technical field of preparation of gel disinfectants, in particular to a preparation method and a preparation system of a gel disinfector.
Background
Hypochlorous acid (HOCl) is a safe and effective green disinfectant, and exists in the form of a water solution, and the concentration of the hypochlorous acid is generally 20-200 ppm. One of the advantages of hypochlorous acid is safety, which the FDA recognized in the united states in 2010 as a food additive. It is an important component of the human immune system, is an immune factor owned by the human body, and the hypochlorous acid generated by the human body by utilizing the neutrophilic sphere in the white blood cells can quickly decompose and kill bacteria and viruses.
The hypochlorous acid aqueous solution can be quickly sterilized, and the reduction product is water, so that the method is pollution-free and residue-free. Hypochlorous acid has strong oxidation effect, can destroy cell membrane and attached pathogenic protein after contacting with microorganism, and can effectively kill Escherichia coli, Staphylococcus aureus, Vibrio cholerae, Salmonella, bacteriophage, etc. Hypochlorous acid sanitizing products are non-toxic disinfectants that are capable of eradicating microorganisms, including bacteria, viruses, and spores, in a variety of environments. Can be used in the fields of wound care, medical device sterilization, food sterilization, hospitals, consumer homes and the like.
However, the hypochlorous acid aqueous solution in the prior art has poor stability, is easily decomposed, and cannot meet the requirement of long-term storage.
The present invention has been made based on this.
Disclosure of Invention
One of the purposes of the invention is to provide a preparation method of a gel disinfectant, which is mainly characterized in that acidic electrolyzed oxidizing water is quickly prepared to obtain a stable gel disinfectant, so that the gel disinfectant has the effect of stable storage, the quality guarantee period of the gel disinfectant is prolonged, and long-distance transportation and long-term storage are facilitated; meanwhile, all components used in the preparation process are friendly to skin tissues, and the disinfection and sterilization effects of the gel disinfectant can be effectively ensured on the basis of ensuring safety and health.
Another object of the present invention is to provide a system for preparing a gel disinfectant, which can rapidly prepare a gel disinfectant by connecting and matching an electrolysis device and a synthesis device, has high synthesis efficiency, and can obtain a gel disinfectant which has a long shelf life and is friendly to skin tissues.
Embodiments of the invention may be implemented as follows:
in a first aspect, an embodiment of the present invention provides a preparation method of a gel disinfectant, including:
mixing acidic oxidation potential water, a stabilizer and a buffering agent to prepare a mixed solution;
adding a gelling agent into the mixed solution while stirring to obtain a gel disinfectant;
wherein the stabilizer comprises cyclodextrin, silicon dioxide and polyvinylpyrrolidone.
In an alternative embodiment, the gelling agent is acrylamide dimethyl ammonium taurate/VP copolymer.
In an alternative embodiment, the buffer is 4-hydroxyethylpiperazine ethanesulfonic acid.
In an optional embodiment, the gel disinfectant comprises the following components in parts by weight: 0.1-2 parts of buffering agent, 0.1-0.5 part of cyclodextrin, 0.1-0.5 part of silicon dioxide, 0.1-1.0 part of polyvinylpyrrolidone, 93-99.5 parts of acidic oxidation potential water and 0.1-3 parts of gelling agent; and the concentration of the gel is 20-200 ppm.
In an alternative embodiment, the preparation method of the gel disinfectant further comprises the step of adding salt water into the electrolysis generating device to electrolyze to obtain the electrolyzed oxidizing water.
In a second aspect, an embodiment of the present invention provides a system for preparing a gel disinfectant, including:
the electrolysis generating device is used for containing the salt water and electrolyzing to generate acidic oxidation potential water;
the synthesis device is communicated with the electrolysis generation device and is used for receiving the electrolyzed oxidizing water;
the stabilizer adding device is communicated with the synthesis device and is used for inputting the stabilizer to the synthesis device;
the buffer adding device is communicated with the synthesis device and is used for inputting the additive to the synthesis device;
the gel adding device is communicated with the synthesis device and is used for inputting gel into the synthesis device;
and the stirring device is arranged in the synthesis device and is used for stirring the acidic oxidation potential water, the stabilizing agent, the buffering agent and the gelling agent to synthesize the gel disinfectant.
In an alternative embodiment, the electrolysis generating device is provided with a first inlet and a first outlet, the first inlet is used for introducing the saline solution, and the first outlet is used for outputting electrolyzed oxidizing water;
the synthesis device is provided with a second inlet and a third inlet, the second inlet is communicated with the electrolysis generation device through a first pipeline, and the third inlet is used for being communicated with the stabilizer adding device, the buffer adding device and the gel adding device in sequence.
In an optional embodiment, the outer edge of the first pipeline is wrapped with a first cooling mechanism, and the first cooling mechanism contains circulating cooling water;
and/or the presence of a gas in the gas,
the outer side edge of the first pipeline is also wrapped with a first light shading layer, and the light shading layer is made of a light shading material;
and/or the presence of a gas in the gas,
the outer edge of the synthesis device is wrapped with a second cooling mechanism, and the second cooling mechanism is filled with circulating cooling water.
In an optional embodiment, the preparation system of the gel disinfectant further comprises a second pipeline, the bottom of the synthesis device is provided with a second outlet, and the second pipeline is communicated with the second outlet to lead out the synthesized gel disinfectant.
In an optional embodiment, the second pipeline has a first end and a second end, the first end is communicated with the second outlet, the second end extends in a direction away from the first end, the second end is provided with a plurality of third outlets arranged side by side, and each third outlet is communicated with one third pipeline;
the preparation system of the gel disinfectant also comprises a plurality of collecting bottles which are arranged in one-to-one correspondence with the third pipelines, and the collecting bottles are made of light-resistant materials.
In an optional embodiment, the outer side of the second pipeline is further wrapped with a second light shading layer, and the material of the second light shading layer is light shading material.
The embodiment of the invention at least has the following advantages or beneficial effects:
the embodiment of the invention provides a preparation method of a gel disinfectant, which comprises the steps of mixing acidic oxidation potential water, a stabilizer and a buffering agent to prepare a mixed solution; adding a gelling agent into the mixed solution while stirring to obtain a gel disinfectant; wherein the stabilizer comprises cyclodextrin, silicon dioxide and polyvinylpyrrolidone. The method can rapidly prepare the stable gel disinfectant by mixing the acidic electrolyzed oxidizing water with the compounded stabilizer and the buffering agent, so that the gel disinfectant has the effect of stable storage, the quality guarantee period of the gel disinfectant is prolonged, and long-distance transportation and long-term storage are facilitated; meanwhile, all components used in the preparation process are friendly to skin tissues, and the disinfection and sterilization effects of the gel disinfectant can be effectively ensured on the basis of ensuring safety and health.
The embodiment of the invention also provides a preparation system of the gel disinfectant, which comprises an electrolysis generation device, a synthesis device, a stabilizer adding device, a buffer adding device, a gel adding device and a stirring device. The synthesis device is communicated with the electrolysis generation device and is used for receiving the acidic oxidation potential water; stabilizer adds device, buffer and gel and adds the device and all communicates with the synthesizer for let in stabilizer, buffer and gel in proper order, the agitating unit is used for stirring the operation in order to synthesize gel disinfectant. The system can rapidly prepare the gel disinfectant through the connection and matching of the electrolysis device and the synthesis device, has high synthesis efficiency, and can obtain the gel disinfectant with longer quality guarantee period.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a schematic diagram of a system for preparing a gel disinfectant provided by an embodiment of the present invention;
FIG. 2 is a graph of the time course of chlorine content in a gel tested using an accelerated aging test with a gel disinfectant provided in accordance with an embodiment of the present invention;
fig. 3 is a graph of the change in pH in a gel tested using an accelerated aging test with a gel disinfectant provided in accordance with an embodiment of the present invention.
Icon: 100-system for preparation of gel disinfectant; 101-an electrolysis generating device; 103-a synthesis unit; 105-stabilizer addition means; 107-buffer addition means; 109-gel adding device; 111-a stirring device; 113-a first inlet; 115-a first outlet; 117 — a first conduit; 119-a second inlet; 121-a third inlet; 123-a first cooling mechanism; 125-a first light-shielding layer; 127-a second cooling mechanism; 129-a second conduit; 131-a second outlet; 133-a third outlet; 135-collection bottle; 137-a second light-shielding layer; 139-access line; 141-addition line.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. indicate an orientation or a positional relationship based on that shown in the drawings or that the product of the present invention is used as it is, this is only for convenience of description and simplification of the description, and it does not indicate or imply that the device or the element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention.
Furthermore, the appearances of the terms "first," "second," and the like, if any, are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.
It should be noted that the features of the embodiments of the present invention may be combined with each other without conflict.
Example 1
Fig. 1 is a schematic block diagram showing the structure of a system 100 for preparing a gel disinfectant according to the present embodiment. Referring to fig. 1, the present embodiment provides a system 100 for preparing a gel disinfectant, by which a gel disinfectant can be prepared to obtain a gel disinfectant with long shelf life and high stability.
In detail, referring to fig. 1 again, in the present embodiment, the system 100 for preparing a gel disinfectant specifically includes an electrolysis generating device 101, a synthesizing device 103, a stabilizer adding device 105, a buffer adding device 107, a gel adding device 109, and a stirring device 111.
Specifically, the electrolysis generating apparatus 101 may be specifically selected from an electrolytic bath containing an aqueous solution of sodium chloride, and an electrolysis operation is performed after energization to generate acidic electrolyzed oxidizing water of sodium hypochlorite, which has a disinfecting function but is not easily stored for a long period of time, and thus the hypochlorous acid gel may be prepared by cooperation with other apparatuses such as the synthesizing apparatus 103.
Specifically, the synthesis device 103 may be a cylindrical tank structure, such as a ceramic cylinder, and the synthesis device 103 is heat-resistant and light-proof and is used for communicating with the electrolysis generating device 101 to receive the electrolyzed oxidizing water obtained by the electrolysis generating device 101. Meanwhile, a stabilizer adding device 105 is also communicated with the synthesizing device 103 and is used for inputting the stability required by the synthesized gel disinfectant into the synthesizing device 103; a buffer adding device 107 is also communicated with the synthesizing device 103 and is used for adding necessary additives to the synthesizing device 103; likewise, a gelling agent addition device 109 is also in communication with the synthesis device 103 for inputting gelling agent to the synthesis device 103. In order to ensure the high efficiency of the synthesis operation, a stirring device 111 is arranged in the synthesis device 103, the stirring device 111 is provided with a stirring rod, a paddle and a driving motor for driving the stirring rod to operate, the stirring rod rotates under the action of the driving motor, and the paddle is driven to rotate, so that the stirring rod is used for stirring acidic oxidation potential water, a stabilizing agent, a buffering agent and a gelling agent to synthesize the gel disinfectant. Of course, the stirring device 111 may be integrated with the synthesis device 103 into a stirring reaction vessel, and this embodiment is not limited thereto. The system can rapidly prepare the gel disinfectant through the connection and matching of the electrolysis device and the synthesis device 103, has high synthesis efficiency, and can obtain the gel disinfectant with longer quality guarantee period.
In this embodiment, the stabilizer includes cyclodextrin, silica, and polyvinylpyrrolidone. The cyclodextrin, the silicon dioxide and the polyvinylpyrrolidone are proportioned and dissolved in water, so that the effect of physically adsorbing hypochlorous acid is achieved, the adsorbed hypochlorous acid has good stability and is not easy to decompose, and therefore, the gel disinfectant with strong stability can be prepared and effectively guaranteed.
It should also be noted that in this example, the gelling agent is acrylamide dimethyl ammonium taurate/VP copolymer. The acrylamide dimethyl ammonium taurate/VP copolymer is used as an acid-resistant gel forming agent, can promote the formation of gel under an acidic condition, and the formed gel has certain shear thixotropy, becomes thin under the action of stress, recovers viscosity after stress is removed, is beneficial to the extrusion of the gel from a container, and is convenient to store and transport. It has a pH of about 5.0 to about 7, facilitating storage and transport of the gel disinfectant.
Meanwhile, in the present example, the buffer is specifically selected to be 4-hydroxyethylpiperazine ethanesulfonic acid. HEPES is a hydrogen ion buffer that controls the pH of the solution over a long period of time in a constant range without toxic effects on the cells. The long-term stability of the pH of the gel system can be effectively controlled, so that the gel system is stably kept in a range of 5-6.5 during the storage period, and the synthetic gel disinfectant can be further ensured to be stored and transported for a long time.
In addition, in order to synthesize a gel disinfectant with good quality, the present example also specifies the amount of each component so that the viscosity and chemical effect of the prepared gel disinfectant can meet the requirements. In detail, the gel disinfectant comprises the following components in parts by weight: 0.1-2 parts of buffering agent, 0.1-0.5 part of cyclodextrin, 0.1-0.5 part of silicon dioxide, 0.1-1.0 part of polyvinylpyrrolidone, 93-99.5 parts of acidic oxidation potential water and 0.1-3 parts of gelling agent. Also, in this embodiment, the gelling agent is present in a concentration of 20-200ppm and typically has a pH of about 2 to 7. Through reasonable proportioning of the components, the gel disinfectant with strong stability can be synthesized by effectively playing the role. Meanwhile, all components used in the preparation process are friendly to skin tissues, and the disinfection and sterilization effects of the gel disinfectant can be effectively ensured on the basis of ensuring safety and health.
Referring to fig. 1 again, in the embodiment, the electrolysis generating apparatus 101 has a first inlet 113 and a first outlet 115, the first inlet 113 is located at the top of the electrolysis generating apparatus 101, the first outlet 115 is located at the bottom of the electrolysis generating apparatus 101, the first inlet 113 is used for feeding saline solution, and the first outlet 115 is used for outputting electrolyzed oxidizing water. Similarly, the synthesis device 103 has a second inlet 119 and a third inlet 121, the second inlet 119 and the third inlet 121 are both located at the top of the synthesis device 103, the second inlet 119 is communicated with the electrolysis generating device 101 through the first pipe 117, and the third inlet 121 is used for communicating with the stabilizer adding device 105, the buffer adding device 107 and the gel adding device 109 in sequence.
It should be noted that, in order to ensure that the third inlet 121 can be communicated with the stabilizing and adding device, the buffering agent feeding device and the gelling agent feeding device 109, an inlet pipeline 139 may be disposed at the third inlet 121, the inlet pipeline 139 extends in the vertical direction and has three inlet ports, and each inlet port may be respectively communicated with the stabilizing agent feeding device 105, the buffering agent feeding device 107 and the gelling agent feeding device 109 through the feeding pipeline 141 to ensure the input of each component, thereby ensuring the efficient operation of the synthesis operation.
Referring to fig. 1 again, in the embodiment, the first cooling mechanism 123 is wrapped around the outer edge of the first pipeline 117, the first cooling mechanism 123 may be a cylindrical cooling cylinder wrapped around the outer side of the first pipeline 117, and the first cooling mechanism 123 contains circulating cooling water, and the temperature of electrolyzed oxidizing water generated by electrolysis can be effectively reduced by introducing the circulating cooling water, so that the electrolyzed oxidizing water is condensed into a liquid state, and the subsequent preparation is facilitated. Of course, in other embodiments, the first cooling mechanism 123 may also be an ice bag wrapped outside the first duct 117, and the embodiment is not limited.
Preferably, the synthesized hypochlorous acid electrolyzed oxidizing water is easily decomposed, so that the outer edge of the first pipeline 117 is further wrapped with a first light shielding layer 125, the light shielding layer is made of a light shielding material or a light shielding material, and the influence of light on the prepared electrolyzed oxidizing water can be effectively prevented, so that the gel disinfectant can be obtained by compounding the synthesized hypochlorous acid electrolyzed oxidizing water with a stabilizer, an additive and a gelling agent after the synthesized hypochlorous acid electrolyzed oxidizing water is introduced into the synthesis device 103.
Referring to fig. 1 again, in order to ensure the normal operation of the synthesis operation, in this embodiment, the outer edge of the synthesis apparatus 103 is wrapped with a second cooling mechanism 127, the second cooling mechanism 127 may be a cylindrical cooling cylinder wrapped outside the synthesis apparatus 103, and the second cooling mechanism 127 contains circulating cooling water, and the temperature of the synthesis reaction can be effectively reduced by introducing the circulating cooling water, so that the reaction temperature is controlled within 10 ℃, and the gel disinfectant can be prepared after various raw materials are added, so as to facilitate the output of the product for storage or use.
Further preferably, for convenience of output and use, the system 100 for preparing gel disinfectant further comprises a second pipeline 129, a second outlet 131 is opened at the bottom of the synthesizing device 103, and the second pipeline 129 is communicated with the second outlet 131 to lead out the synthesized gel disinfectant.
In detail, the second duct 129 has a first end communicating with the second outlet 131 and a second end extending away from the first end. Moreover, a plurality of third outlets 133 arranged side by side are formed in the second end, and each third outlet 133 is communicated with a third pipeline; the system 100 for preparing a gel disinfectant further comprises a plurality of collecting bottles 135 which are arranged in one-to-one correspondence to the plurality of third pipelines, and the collecting bottles 135 are made of light-shielding materials so as to collect and store the prepared hypochlorous acid gel. The light-resistant material can prolong the storage time and ensure the convenience of transportation and use.
Certainly, in order to ensure that the output process from the second pipeline 129 is not affected, the outer side of the second pipeline 129 may also be wrapped with a second light shielding layer 137, and a light shielding material of the second light shielding layer 137 may also be selected as a light shielding material, so that the influence of light on the prepared hypochlorous acid gel can be effectively prevented, thereby being beneficial to storage and transportation.
It should be noted that, in order to ensure reasonable matching between the devices, control mechanisms such as a water stop clip or an electromagnetic valve may be disposed at the inlet and the outlet of each device, which is not limited in this embodiment.
It should be noted that each apparatus used in the embodiments of the present invention may be prepared in a laboratory, or may be scaled up to a factory for preparation, and the present embodiment is not limited thereto.
Meanwhile, the embodiment of the invention also provides a preparation method of the gel disinfectant, which is prepared by using the preparation system and specifically comprises the following steps:
s1: mixing acidic oxidation potential water, a stabilizer and a buffering agent to prepare a mixed solution;
s2: adding the gel into the mixed solution while stirring to obtain the gel disinfectant.
In detail, in this embodiment, electrolyzed oxidizing water is first prepared by the electrolysis generating apparatus 101, the electrolyzed water is drawn out into the synthesizing apparatus 103 by the opaque first pipe 117, and the stirring apparatus 111 is turned on to stir. Meanwhile, nitrogen can be introduced into a synthesis device 103 with a stirring device 111, the temperature of the stirring kettle is controlled not to exceed 10 ℃ by adopting circulating low-temperature water, and acidic oxidation water, hydroxyethyl-piperazine-ethionic acid, cyclodextrin, silicon dioxide and polyvinylpyrrolidone are sequentially added and stirred and dissolved to form a mixed solution. Adding gel into the mixture, and stirring to obtain gel. For storage, the gel may be stored by injecting it into a light-shielding plastic collection bottle 135 through the second pipe 129.
Specifically, the following formula is specifically adopted for configuration in this embodiment, and the following process is specifically provided:
s1: sequentially adding 99.5 parts of acidic oxidizing water, 0.1 part of hydroxyethyl piperazinethiosulfonic acid, 0.1 part of cyclodextrin, 0.1 part of silicon dioxide and 0.1 part of polyvinylpyrrolidone, and stirring to dissolve to obtain a mixed solution;
s2: adding 0.1 part of acrylamide dimethyl ammonium taurate/VP copolymer into the gel while stirring, and stirring the mixture in vacuum to form viscous flowable gel;
s3: the tube was placed in a light-resistant collection bottle 135 and stored at room temperature.
Example 2
The difference between this embodiment and embodiment 1 is that, in this embodiment, the preparation method of the gel disinfectant specifically includes:
s1: sequentially adding 93 parts of acidic oxidation water, 2 parts of hydroxyethyl piperazine ethiosulfonic acid, 0.5 part of cyclodextrin, 0.5 part of silicon dioxide and 1.0 part of polyvinylpyrrolidone, and stirring to dissolve to obtain a mixed solution;
s2: adding 3.0 parts of acrylamide dimethyl ammonium taurate/VP copolymer into the gel while stirring, and stirring the mixture in vacuum to form viscous flowable gel;
s3: the tube was placed in a light-resistant collection bottle 135 and stored at room temperature.
Example 3
The difference between this embodiment and embodiment 1 is that, in this embodiment, the preparation method of the gel disinfectant specifically includes:
s1: adding 95 parts of acidic oxidation water, 0.5 part of hydroxyethyl piperazine ethiosulfonic acid, 0.5 part of cyclodextrin, 0.5 part of silicon dioxide and 0.5 part of polyvinylpyrrolidone in sequence, and stirring and dissolving to obtain a mixed solution;
s2: adding 2 parts of acrylamide dimethyl ammonium taurate/VP copolymer as a gelling agent under stirring, and stirring in vacuum to form a viscous flowable gel;
s3: the tube was placed in a light-resistant collection bottle 135 and stored at room temperature.
Experimental example 1
Referring to fig. 2 and 3, the gel disinfectant synthesized in examples 1-3 was tested for the change in chlorine content over time and the change in pH in the gel using an accelerated aging test. The results show that the hydrogel formulation is stable for at least 6 months, up to 3 years. The hydrogel formulation has a change in free available chlorine of less than 10% after storage for at least 12 months; the pH is stable at 6.2 to 6.8; after storage for at least 12 months, the killing rate of microorganisms can reach more than 99 percent in 30 seconds.
In summary, in the preparation method of the gel disinfectant provided by the embodiment of the invention, the acidic electrolyzed oxidizing water is mixed with the compounded stabilizer and the buffer agent to quickly prepare the stable gel disinfectant, so that the gel disinfectant has the effect of stable storage, and the shelf life of the gel disinfectant can be prolonged, thereby facilitating long-distance transportation and long-term storage. The preparation system 100 of the gel disinfectant provided by the embodiment of the invention can quickly prepare the gel disinfectant through the connection and matching of the electrolysis device and the synthesis device 103, has high synthesis efficiency, and can obtain the gel disinfectant which has a longer shelf life and is friendly to skin tissues.
The above description is only for the specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims (10)

1. A method of preparing a gel disinfectant, comprising:
mixing acidic oxidation potential water, a stabilizer and a buffering agent to prepare a mixed solution;
adding a gelling agent into the mixed solution while stirring to obtain a gel disinfectant;
wherein the stabilizer comprises cyclodextrin, silicon dioxide and polyvinylpyrrolidone.
2. The method of preparing a gel disinfectant as set forth in claim 1, wherein:
the gel is acrylamide dimethyl ammonium taurate/VP copolymer.
3. The method of preparing a gel disinfectant as set forth in claim 1, wherein:
the buffer is 4-hydroxyethyl piperazine ethanesulfonic acid.
4. The method of preparing a gel disinfectant as set forth in claim 1, wherein:
the gel disinfectant comprises the following components in parts by weight: 0.1-2 parts of said buffering agent, 0.1-0.5 parts of said cyclodextrin, 0.1-0.5 parts of said silica, 0.1-1.0 parts of said polyvinylpyrrolidone, 93-99.5 parts of said electrolyzed oxidizing water, and 0.1-3 parts of a gelling agent; and the concentration of the gel is 20-200 ppm.
5. The method of preparing a gel disinfectant as set forth in claim 1, wherein:
the preparation method of the gel disinfectant also comprises the step of adding salt water into the electrolysis generating device for electrolysis to prepare the acidic oxidation potential water.
6. A system for preparing a gel disinfectant, comprising:
the electrolysis generating device is used for containing the salt water and electrolyzing to generate acidic oxidation potential water;
the synthesis device is communicated with the electrolysis generation device and is used for receiving the electrolyzed oxidizing water;
stabilizer adding device, which is communicated with the synthesizing device and is used for inputting stabilizer to the synthesizing device;
a buffer adding device which is communicated with the synthesizing device and is used for inputting additives into the synthesizing device;
the gel adding device is communicated with the synthesis device and is used for inputting gel to the synthesis device;
and the stirring device is arranged in the synthesis device and is used for stirring the electrolyzed oxidizing water, the stabilizer, the buffer and the gel to synthesize the gel disinfectant.
7. The system for preparing a gel disinfectant as set forth in claim 6, wherein:
the electrolysis generating device is provided with a first inlet and a first outlet, the first inlet is used for introducing saline solution, and the first outlet is used for outputting electrolyzed oxidizing water;
the synthesis device is provided with a second inlet and a third inlet, the second inlet is communicated with the electrolysis generation device through a first pipeline, and the third inlet is used for being communicated with the stabilizer adding device, the buffer adding device and the gel adding device in sequence.
8. The system for preparing a gel disinfectant as set forth in claim 7, wherein:
the outer edge of the first pipeline is wrapped with a first cooling mechanism, and circulating cooling water is contained in the first cooling mechanism;
and/or the presence of a gas in the gas,
the outer side edge of the first pipeline is further wrapped with a first light shading layer, and the light shading layer is made of a light shading material;
and/or the presence of a gas in the gas,
and a second cooling mechanism is wrapped on the outer edge of the synthesizing device, and circulating cooling water is contained in the second cooling mechanism.
9. The system for preparing a gel disinfectant as set forth in claim 7, wherein:
the preparation system of the gel disinfectant also comprises a second pipeline, a second outlet is formed in the bottom of the synthesis device, and the second pipeline is communicated with the second outlet so as to guide out the synthesized gel disinfectant.
10. A system for preparing a gel disinfectant as set forth in claim 9, wherein:
the second pipeline is provided with a first end and a second end, the first end is communicated with the second outlet, the second end extends towards the direction far away from the first end, the second end is provided with a plurality of third outlets arranged side by side, and each third outlet is communicated with a third pipeline;
the preparation system of the gel disinfectant further comprises a plurality of collecting bottles which are arranged in one-to-one correspondence with the plurality of third pipelines, and the collecting bottles are made of light-resistant materials.
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