JP2012254802A - Pharmaceutical liquid container - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a pharmaceutical liquid container capable of preparing pharmaceutical liquid having a predetermined uniform concentration by quickly dissolving a pharmaceutical product with a simple operation and having a simple entire structure with the minimum number of components.SOLUTION: This pharmaceutical liquid container comprises: a container 10 storing dissolution liquid W; an inner cylinder 20 mounted to a mouth part of the container and storing a pharmaceutical product T; an inner plug 30 inserted into the inner cylinder and having a spout opening 33 at a distal end; and a screw cap 40 mounted on the mouth part of the container. The inner cylinder 20 includes a large-diameter part 21 fixed to the mouth part of the container, a small-diameter part 22 continuous to a lower end of the large-diameter part via a first thin part 24, and a bottom member 23 having a leg part 23b closing a lower end of the small-diameter part via a second thin part. When the cap 40 is fastened, the small-diameter part 22 is pressed down via the inner plug 30 to break the first thin part 24. When the cap is further fastened, the leg 23b reaches the bottom of the container 10 to break the second thin-wall part, and the lower end of the small-diameter part 22 is opened.

Description

  TECHNICAL FIELD The present invention relates to a drug solution container that can be used as a drug solution by separating and storing a tablet or powder drug-dissolved drug product and its solution, and dissolving the drug product by a simple operation during use.

  There is known a chemical solution container that separates and stores a preparation dissolved in use and its solution and dissolves the preparation during use (Patent Document 1).

  A conventional liquid chemical container has a spout and has a cover body for storing a solid preparation, a middle cylinder for screw-connecting an upper member and a lower member, and a lower member for the middle cylinder to store a solution. The container is connected to the container in a straight line, and an inner plug with a plug is attached to the upper end of the upper member of the middle cylinder, and a cap for sealing the spout is provided. When the upper and lower members of the middle cylinder are rotated relative to each other to shorten both lengths, the upper member side plug is pushed up through a push-up member provided upward at the upper end of the lower member, and a communication hole provided in the plug is opened. Thus, the solution on the container side is allowed to flow into the cover body, and the preparation in the cover body is dissolved and dropped from the spout for use.

JP 2010-83514 A

  In such a conventional technique, the solution in the container flows into the cover body only through the communication hole opened in the plug, so that the dissolution of the preparation does not proceed rapidly, and the drug solution has a predetermined uniform concentration. In addition to being difficult to adjust, there are problems such as a large number of parts and a complicated overall structure.

  Therefore, in view of the problems of the prior art, the object of the present invention is to use the inner cylinder that sequentially breaks the intermediate portion and the lower end via the first and second thin portions, thereby quickly and quickly preparing the preparation. It is an object of the present invention to provide a chemical solution container that can be dissolved in a solution and adjusted to a chemical solution having a predetermined uniform concentration and has a simple overall structure with a minimum number of parts.

  The configuration of the present invention for achieving such an object includes a container for storing a solution, an inner cylinder that is attached to the mouth of the container and that stores the preparation, and is inserted into the inner cylinder and has a spout at the tip. The inner cylinder has a large-diameter portion fixed to the mouth portion of the container and a lower end of the large-diameter portion via the first thin-wall portion. A small-diameter portion that is connected, and a bottom member with a leg that closes the lower end of the small-diameter portion via the second thin-walled portion, and when the cap is tightened, the small-diameter portion is pushed down via the inner plug and the first The gist is that when the thin portion is broken and the cap is further tightened, the leg reaches the bottom of the container, and the second thin portion is broken to open the lower end of the small diameter portion.

  Note that the first thin portion can be disposed obliquely with respect to the common axis of the large diameter portion and the small diameter portion.

  Further, the inner plug may have a main body portion that penetrates the large diameter portion so as to be relatively movable and reaches the small diameter portion, and an extension portion that extends downward from the main body portion and is inserted into the small diameter portion. You may form the slit of a lower end opening from a part to an extension part.

  Further, the bottom member may be attached to the lower end of the small-diameter portion via the second thin portion and the thin hinge portion.

  According to the configuration of the present invention, the inner cylinder that is attached to the mouth portion of the container and stores the preparation includes the upper and lower large-diameter portions, the small-diameter portion, and the second thin-walled portion that are connected via the intermediate first thin-wall portion. And a bottom member that closes the lower end of the small diameter portion via the portion. Therefore, when the inner cylinder is tightened with the cap and the small diameter part is pushed down through the inner plug, the first thin part is broken, the large diameter part and the small diameter part are separated, and the upper part of the container is separated from the inside of the inner cylinder. When the cap is further tightened, the leg of the bottom member reaches the bottom of the container, the bottom member is pushed up relatively, the second thin part is broken, and the lower end of the small diameter part opens at the bottom of the container Is done. Therefore, the solution in the container can easily flow into the inner cylinder through the upper and lower openings, and the preparation in the inner cylinder can be quickly dissolved to prepare a drug solution with a predetermined uniform concentration. In addition, the container, the inner cylinder, the inner stopper, and the cap can be integrally formed of an appropriate plastic material, and the overall structure is simple.

  The solid preparation stored in the inner cylinder may be either a tablet or a powder, and is completely separated from the solution in the container by the inner cylinder, so it may be altered before use. In addition, there is no possibility that only the solution before dissolution is misused. However, it is preferable that the required rotation operation angle at the time of tightening the cap is set to, for example, less than one rotation by employing a multi-thread screw having a large lead.

  The first thin-walled portion connecting the large-diameter portion and the small-diameter portion is disposed obliquely with respect to the shaft center, so that the starting point for breaking is set to one point, and the pressing force required for breaking is reduced and good. A feeling of use can be realized.

  The inner plug is provided with a main body part that penetrates the large diameter part of the inner cylinder and a downward extension part attached to the main body part, and when the cap is tightened, the main body part is guided to the large diameter part and correctly faces downward. The small-diameter portion is restrained via the extension portion, and the first thin-walled portion is broken and the small-diameter portion separated from the large-diameter portion does not float freely in the container. In addition, when a small diameter part floats in a container, it is difficult to open the lower end of a small diameter part continuously.

  The slit at the lower end that is formed in the inner plug breaks the first thin-walled portion in the middle of the inner cylinder to allow the interior of the inner cylinder and the interior of the container to communicate over a large area, and the liquid pool in the container disappears. This contributes to reducing the residual liquid in the container.

  The bottom member is attached to the lower end of the small-diameter portion via a thin hinge portion, so that even if the second thin-walled portion breaks, it does not separate from the small-diameter portion. No unpleasant noises.

Whole structure exploded perspective view Overall assembly vertical section Configuration diagram of inner cylinder (1) Configuration diagram of the inner cylinder (2) Explanation of the structure of the inner plug Operation explanatory diagram equivalent to FIG.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings.

  A chemical | medical solution container is equipped with the container 10, the inner cylinder 20, the inner stopper 30, and the cap 40 (FIG. 1, FIG. 2). FIG. 2 also shows a tablet preparation T stored in the inner cylinder 20 and a solution W stored in the container 10.

  The container 10 has an opening 12 at the top of the body 11. For example, a three-thread male screw 13 is formed on the outer periphery of the mouth 12, and an annular rib 14 is formed on the outer periphery of the mouth 12. The upper end portion of the mouth portion 12 is formed thinly via an upward stepped portion 12a, and an annular engagement rib 12b is formed at the upper end of the outer periphery of the thin portion. The container 10 is integrally formed of a transparent or translucent plastic material having appropriate elasticity such as PP.

  The inner cylinder 20 has a large-diameter portion 21 and a small-diameter portion 22 that are connected vertically, and a bottom member 23 with a leg 23b attached to the lower end of the small-diameter portion 22 (FIGS. 1 and 3). 3A and 3B are longitudinal half sectional views corresponding to a front view and a right side view of the inner cylinder 20, respectively.

  An outer flange 21 a is formed at the upper end of the large diameter portion 21. A short skirt portion 21b that hangs downward is formed on the outer peripheral edge of the outer flange 21a, and an annular engagement rib 21c is formed on the inner peripheral lower portion of the skirt portion 21b (FIG. 4B). The thin portion at the upper end of the mouth portion 12 of the container 10 can be fitted into the skirt portion 21b, and the engagement ribs 12b and 21c can be engaged vertically to prevent the skirt portion 21b from being pulled out. However, FIG. 4 (A) is an enlarged bottom view corresponding to the arrow X in FIG. 3 (A), and FIGS. 4 (B) and 4 (C) are enlarged views of main parts of FIG. 3 (B).

  The large-diameter portion 21 and the small-diameter portion 22 are connected coaxially up and down via a ring-shaped first thin-walled portion 24 (FIGS. 3 and 4C). The outer diameter of the small-diameter portion 22 is smaller than the inner diameter of the large-diameter portion 21, and the first thin-walled portion 24 is configured so that the lower end of the large-diameter portion 21 and the upper end of the small-diameter portion 22 are connected almost horizontally. 21 and the small-diameter portion 22 are arranged obliquely with a tilt angle θ> 90 ° with respect to the common axis (FIG. 3A). An upward step 22a is formed on the inner peripheral upper portion of the small diameter portion 22, and the small diameter portion 22 is formed such that the upper inner diameter of the step 22a is larger than the lower inner diameter.

  The bottom member 23 is formed by vertically extending a leg 23b having a V-shaped cross section with respect to a trapezoidal bottom plate 23a formed at the lower end of the small diameter portion 22 (FIGS. 3 and 4A). In addition, the leg 23b is suspended from the bottom plate 23a in an eccentric position so that the apex angle is aligned with the apex side of the bottom plate 23a.

  One side of the bottom side of the bottom plate 23a is formed in the thin hinge portion 23c, and each side other than the bottom side of the bottom plate 23a is formed in the second thin portion 23d. Therefore, the bottom plate 23a closes the lower end of the small diameter portion 22 via the second thin portion 23d and the thin hinge portion 23c. In addition, on the outer periphery of the lower end of the small diameter portion 22, short downward auxiliary legs 22b, 22b,... Further, the lower surface of the leg 23b is formed with inclined surfaces 23e and 23e with a lower surface protruding toward the hinge portion 23c.

  The inner plug 30 is formed by projecting a nozzle cylinder 33a for the spout 33 through an outer flange 32 at the upper end of a cylindrical main body 31 and coaxially providing an extension 34 at the lower end of the main body 31. (FIGS. 1 and 5). However, FIG. 5 (A) and (B) are the longitudinal half sectional views equivalent to the front view and right side view of the inner plug 30, respectively.

  The upper outer diameter of the main body 31 is formed slightly larger than the outer diameter below the step 31a via the downward step 31a. In addition, slits 35 and 35 having an open lower end are formed axially symmetrically from the intermediate portion of the main body portion 31 to the extension portion 34. The outer diameter of the extension portion 34 is smaller than the outer diameter of the main body portion 31, but the inner diameter of the extension portion 34 is the same as the inner diameter of the main body portion 31. In addition, the lower-end outer periphery of the main-body part 31 and the extension part 34 is chamfered diagonally, respectively.

  Anti-slip knurls 41, 41... Are formed on the outer periphery of the cap 40 (FIGS. 1 and 2). On the inner periphery of the cap 40, for example, a three-thread female screw 42 adapted to the male screw 13 on the container 10 side is formed. Further, a seal portion 43 that seals the spout 33 of the inner plug 30 is formed on the top surface of the cap 40, and a skirt 44 that houses the nozzle cylinder 33a for the spout 33 is suspended.

  The inner cylinder 20 is integrally formed of, for example, transparent or translucent LDPE. The inner plug 30 and the cap 40 are each integrally formed of a hard plastic material such as HDPE or PP.

  The inner cylinder 20 has a large-diameter portion 21 inserted into the mouth portion 12 of the container 10, the thin portion at the upper end of the mouth portion 12 is accommodated in the skirt portion 21 b at the upper end, and the engagement ribs 21 c and 12 b are engaged with each other. The diameter portion 21 is fixed to the mouth portion 12 and attached to the mouth portion 12 (FIGS. 2 and 4B). That is, the outer diameter of the large diameter portion 21 matches the inner diameter of the mouth portion 12, and the length of the large diameter portion 21 is shorter than the length of the mouth portion 12. At this time, the leg 23 b at the lower end of the small-diameter portion 22 depending on the container 10 is opposed to the bottom of the container 10 with a margin gap d.

  On the other hand, the inner plug 30 is inserted into the large-diameter portion 21 of the inner cylinder 20 at a portion below the step portion 31 a of the main body portion 31, and the inner cylinder 20 is inserted into the upper portion of the small-diameter portion 22. Assemble together. At this time, the lower end of the main body portion 31 abuts one point of the oblique upper end of the small diameter portion 22, and the lower end of the extension portion 34 reaches the immediate vicinity of the step portion 22 a on the inner periphery of the small diameter portion 22. Further, the lower part of the main body part 31 from the step part 31a is substantially the same length as the large-diameter part 21, and can be moved relative to the large-diameter part 21, and the upper part from the step part 31a has a large diameter. It can be press-fitted into the portion 21.

  Prior to combining the inner plug 30 with the inner cylinder 20, the preparation T is accommodated in the inner cylinder 20, and before the inner cylinder 20 is attached to the mouth portion 12 of the container 10, the solution is dissolved in the container 10. W is stored. Therefore, as shown in FIG. 2, when the container 10 containing the solution W, the inner cylinder 20 containing the preparation T, and the inner plug 30 are assembled together, the cap 40 is attached to the mouth 12 of the container 10 and the spout is formed. 33 is sealed and the whole is packaged and stored, for example, with a shrink film (not shown).

  When the preparation T is used after being dissolved, the entire package is opened, the cap 40 is tightened, and the upper part from the step part 31a of the main body part 31 of the inner plug 30 is used as the large diameter part 21 of the inner cylinder 20. Press-fit (in the directions of arrows K1 and K2 in FIG. 6A). At this time, the cap 40 presses the tip of the nozzle cylinder 33a of the inner plug 30 through the top seal portion 43, but the upper surface of the outer flange 32 may be pressed together by the lower end of the skirt 44. On the other hand, when the inner plug 30 is pushed down by the cap 40 in this way, the small-diameter portion 22 of the inner cylinder 20 is driven downward via the main body portion 31 of the inner plug 30, so that the large-diameter portion 21 and the small-diameter portion 22 are interposed. The first thin-walled portion 24 is broken, and the leg 23b at the lower end of the small-diameter portion 22 reaches the bottom of the container 10 (FIG. 6A).

  Therefore, when the cap 40 is further tightened and the inner plug 30 is pushed down until the lower surface of the outer flange 32 of the inner plug 30 comes into contact with the upper surface of the outer flange 21 a at the upper end of the large diameter portion 21, The thin-walled portion 23d is broken, and the bottom plate 23a is obliquely pushed up into the small-diameter portion 22 through the hinge portion 23c, so that the lower end of the small-diameter portion 22 is opened (FIG. 6B). At this time, the small diameter portion 22 is separated downward from the large diameter portion 21, and an opening P having a large area is formed between the large diameter portion 21 and the small diameter portion 22 corresponding to each slit 35.

  That is, since the inside of the inner cylinder 20 and the inside of the container 10 communicate with each other at the upper and lower portions of the container 10, the entire solution is inverted or shaken to cause the solution W in the container 10 to flow into the inner cylinder 20. The drug solution can be prepared by quickly dissolving the preparation T with the solution W. When the preparation T is completely dissolved, the cap 40 is rotated in the returning direction to be removed from the mouth portion 12, and the body portion 11 of the container 10 is squeezed with fingers, and the drug solution is dropped from the spout 33 for use. The auxiliary legs 22b, 22b... At the lower end of the small diameter portion 22 prevent the lower end of the small diameter portion 22 after opening from coming into close contact with the bottom of the container 10. Moreover, auxiliary leg 22b, 22b ... prevents that the small diameter part 22 after opening remove | deviates from the extension part 34 of the inside plug 30. FIG.

  In the above description, the leg 23b having the slopes 23e and 23e at the lower end is easy to tilt when reaching the bottom of the container 10 in combination with the eccentric position of the hanging position with respect to the bottom plate 23a. The second thin portion 23d is easily broken. However, the leg 23b may be deformed into a shape other than the shape shown in the figure.

  In addition, when the chemical solution container is assembled as shown in FIG. 2, a stopper ring (not shown) is detachably mounted between the lower end of the cap 40 and the annular rib 14 and the cap 40 is accidentally tightened. Can be prevented. The step portion 31a of the inner plug 30 increases the required pressing force by inserting the main body portion 31 into the large-diameter portion 21 up to the prescribed standby position in FIG. 2, and the rotational torque in the tightening direction of the cap 40 Has an advantage that it is easy to realize an automatic assembly operation.

  Furthermore, by making the container 10 and the inner cylinder 20 transparent or translucent, the opening state of the inner cylinder 20 and the dissolution state of the preparation T can be confirmed from the outside.

  The present invention can be widely applied to uses such as eye drops, reagents, and external preparations that use the preparation T dissolved in use.

T ... Preparation W ... Dissolved solution 10 ... Container 12 ... Mouth part 20 ... Inner cylinder 21 ... Large diameter part 22 ... Small diameter part 23 ... Bottom member 23b ... Leg 23c ... Hinge part 23d ... 2nd thin part 24 ... 1st Thin part 30 ... Inner plug 31 ... Main body part 33 ... Outlet 34 ... Extension part 35 ... Slit 40 ... Cap

Patent applicant Shingo Chemical Co., Ltd.

Claims (5)

  A container for storing the lysate, an inner cylinder that is attached to the mouth of the container, a preparation is stored, an inner plug that is inserted into the inner cylinder and has a spout at the tip, and is attached to the mouth of the container The inner cylinder includes a large-diameter portion fixed to the mouth portion of the container, a small-diameter portion connected to the lower end of the large-diameter portion via a first thin-walled portion, A bottom member with a leg that closes a lower end of the small-diameter portion through the thin-walled portion, and when the cap is tightened, the small-diameter portion is pushed down through the inner plug, and the first thin-walled portion When the cap is broken and the cap is further tightened, the leg reaches the bottom of the container, the second thin portion is broken, and the lower end of the small diameter portion is opened.   The chemical container according to claim 1, wherein the first thin portion is disposed obliquely with respect to a common axis of the large diameter portion and the small diameter portion.   The inner plug has a main body portion that penetrates the large diameter portion so as to be relatively movable and reaches the small diameter portion, and an extension portion that extends downward from the main body portion and is inserted into the small diameter portion. The chemical container according to claim 1 or 2.   The chemical container according to claim 3, wherein the inner plug forms a slit having a lower end opened from the main body portion to the extension portion.   The chemical solution container according to any one of claims 1 to 4, wherein the bottom member is attached to a lower end of the small diameter portion via the second thin portion and a thin hinge portion.

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