JP2007314462A - External preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new external preparation effective for preventing the aging of the skin, keeping the skin to a healthy state and further exhibiting sufficient effect to ameliorate the drying of the skin and various skin diseases by lowering the oxidation potential of the skin surface. <P>SOLUTION: The external preparation contains one or more substances selected from each of the plant extracts shown in (A) and substances shown in (B) and has an oxidation-reduction potential of ≤200 mV in a pH range of 4.5-11.0. (A) Portulaca, semi-fermented tea, Rhodiola euryphylla, Magnolia obovata, fennel, Citrus unshiu, Zizyphus jujube, Coix lacryma-jobi, Lycium chinense and Magnolia liliflora; (B) uronic acid-containing polysaccharides having an average molecular weight of 1,000-10,000 and their derivatives. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a novel external preparation that prevents skin aging and keeps the skin healthy by reducing the oxidation potential of the skin surface.

The surface of human skin is constantly exposed to the atmosphere contaminated with acidic substances, and is irritated by oxidation and radical reactions caused by strong ultraviolet rays. Moreover, due to the deterioration of water quality, chlorination of tap water and pool water becomes more powerful and has an oxidizing action enough to discolor dyed clothing. Therefore, the skin that comes into contact with water is always exposed to the threat of deterioration due to oxidation.
Under such circumstances, the deterioration of the skin subjected to these oxidizing effects weakens the protective function of the skin, causes the skin to dry and various skin diseases, and promotes pruritus.

In recent years, active oxygen has attracted attention as a factor that oxidizes biological components, and its adverse effect on living organisms has become a problem. Active oxygen causes various reactions in the living body of animals, and it is known that skin oxygen is deeply involved in these damages and aging.
In other words, (active oxygen) is essential for the sterilization mechanism of phagocytes and plays an important role in the removal of viruses and cancer cells, but excessive production of active oxygen is a biological molecule that forms membranes and tissues in the body. Attack and induce various diseases. For example, it is considered that biological tissues such as collagen are decomposed, denatured or cross-linked, or lipids are oxidized to produce lipid peroxides that damage cells, and these disorders caused by active oxygen are It is thought to cause skin aging such as wrinkle formation and reduced elasticity.

Active oxygen is generated by extraneous stimuli such as ultraviolet rays, radiation, and heavy metals, and in vivo metabolism (energy metabolism process in living cells). Superoxide (superoxide anion generated by one-electron reduction of oxygen molecule), hydrogen peroxide Singlet oxygen, hydroxy radical, and the like. These active oxygens are involved in the oxidation of substances and serve as an index for evaluation of antioxidant power (antioxidant power is evaluated with the ability to scavenge active oxygen such as hydroxy radicals).
In the living body, radicals generated first based on oxygen are superoxide, and other radicals such as hydroxy radicals are generated via superoxide. In addition, it is known that hydrogen peroxide accumulates in the cells among the active oxygen species due to ultraviolet rays, etc., but the Fenton reaction is caused by iron ions and copper ions present in trace amounts in the skin tissue from this hydrogen peroxide. It is said that a hydroxyl radical that is catalyzed and has the highest tissue damage is generated.

Intracellular superoxide is converted into hydrogen peroxide by superoxide dismutase (hereinafter abbreviated as “SOD”) produced in the cell, but the amount of SOD decreases with age, and the decrease in SOD amount Increased intracellular concentration of superoxide, superoxide damages the body (eg, tissue damage such as rheumatoid arthritis and Behcet's disease, myocardial infarction, stroke, cataract, diabetes, arteriosclerosis, stiff shoulders, coldness, skin spots・ Failures such as wrinkles).
As an SOD-like agent that prevents or treats such a disorder, in order to compensate for a decrease in the amount of SOD, an extract from urgon (Patent Document 1) and a fruit juice of spinach pear that is a rose family plant (Patent Document 2) However, these SOD-like agents are problematic in terms of safety and the like.

  In addition, screening for substances having an erasing action on reactive oxygen species such as hydroxy radicals has been performed, and attempts have been made to incorporate plant-derived components such as vitamin E group compounds and tea tannin into skin external preparations. It was. In addition, chelating agents are also blended to inhibit the generation of hydroxy radicals. Furthermore, a substance that eliminates hydrogen peroxide, which is a precursor for producing hydroxy radicals, has been searched for, and a button extract is known (Patent Document 3).

Plant extracts evaluated on the basis of the above methods have been used in conventional external preparations and cosmetics that promote antioxidant and anti-aging properties.
However, these external preparations and cosmetics are insufficient for alleviating skin dryness and various skin diseases, and reactive oxygen species such as hydrogen peroxide and hydroxy radicals are involved in the chain oxidation reaction. Even if these are erased individually, there are problems such as insufficient to prevent a series of peroxidation reactions in vivo.

Japanese Unexamined Patent Publication No. 64-50877 Japanese Patent Laid-Open No. 3-83548 Japanese Patent Application No. 7-191060

Based on the method of evaluating with the ability to scavenge active oxygen such as hydroxy radicals involved in the oxidation of substances, the conventional (exhibited antioxidant and anti-aging) external screenings and cosmetics that have been screened are used for skin dryness and various skin diseases. There were insufficient points to relax.
Accordingly, an object of the present invention is to provide a novel external preparation that can exert an effect sufficient to alleviate skin dryness and various skin diseases (prevent skin aging and keep skin healthy). is there.

  As a result of diligent research focusing on the redox potential as a method completely different from the conventional method for measuring antioxidant power, the present inventors have found that, "Suveruhiyu, semi-fermented tea, Hongjingtian, Kobak, Fennel, Chen, One or more selected from the group consisting of each plant extract of Taisou, Yokuinin, wolfberry, and Shinyi, uronic acid-containing polysaccharides having an average molecular weight of 1,000 to 10,000 and derivatives thereof, and having an active ingredient, pH 4.5 to pH 11. It was found that an external preparation characterized by having an oxidation-reduction potential of 200 mV or less in the range of 0 or less repairs and relieves dry skin and various skin diseases. Thus, the present invention has been completed.

That is, the invention according to claim 1 includes at least one selected from the group consisting of the plant extract listed in (A) below and the substance (B) as an active ingredient, and has a pH of 4.5 to 11. The present invention relates to an external preparation characterized by having an oxidation-reduction potential of 200 mV or less in a range of 0 or less.
(A) Purslane, semi-fermented tea, Hongjingten, Kobak, fennel, Chen, Taiso, Yokuinin, wolfberry, Shinyi (B) Uronic acid-containing polysaccharide having an average molecular weight of 1,000 to 10,000 and its derivatives The present invention comprises at least one selected from the plant extracts listed in (A) above and at least one selected from the group consisting of the above substances (B) as active ingredients, and has a pH of 4.5 or more and a pH of 11.0. In the following ranges, the present invention relates to an external preparation characterized by having an oxidation-reduction potential of 200 mV or less.
Invention of Claim 3 relates to the external preparation of Claim 1 or 2 whose content of the non volatile matter of the said active ingredient is 0.001 to 5 weight%.
The invention according to claim 4 contains sodium oligoalginate as the uronic acid-containing polysaccharide (B) having an average molecular weight of 1,000 to 10,000 and a derivative thereof, according to any one of claims 1 to 3. It relates to an external preparation.
In the invention according to claim 5, the dosage form is any one selected from the group consisting of pasta, ointment, cream, liquid, gel, patch, patch, and patch. It relates to the external preparation in any one of 4 thru | or 4.
The invention according to claim 6 relates to the external preparation according to any one of claims 1 to 5 in the form of a cosmetic.

  According to the preparation for external use according to the present invention, in the range of pH 4.5 or more and pH 11.0 or less, each plant extract having a redox potential of 200 mV or less (subtilis, semi-fermented tea, Hongjing heaven, Kobaku, fennel, Skin aging and aging by using as an active ingredient at least one selected from the group consisting of “extracts of Chen, Tiso, Yokuinin, wolfberry, and Shini”) and “uronic acid-containing polysaccharides having an average molecular weight of 1,000 to 10,000” It is possible to prevent rustling feeling, pruritus feeling, or burning feeling caused by dryness or various skin diseases.

According to the present invention, “in the range of pH 4.5 or more and pH 11.0 or less, having a redox potential of 200 mV or less, an extract from each plant listed in (A) below and a group (B) The embodiment of “external preparation containing one or more selected from active ingredients” will be described in detail below.
(A) purslane, semi-fermented tea, red scenic tempura, Kobaku, fennel, Chen, Taiso, Yokuinin, wolfberry, Shinyi (B) uronic acid-containing polysaccharides having an average molecular weight of 1,000 to 10,000 and their derivatives

First, the extract (extract) of each plant listed in the above (A), which can be an active ingredient of the external preparation according to the present invention, can be found in subhihiyu, semi-fermented tea [olong tea, puer tea]・ Explain in the order of Fennel, Chen, Tiso, Yokuinin, Kuko, and Shiny.
The plant extract refers to various solvent extracts obtained by extracting each part of the plant at room temperature or under heating, or by using an extraction device such as a Soxhlet extractor. Liquid, its concentrated liquid or its dry powder.

[Surihiyu]
In the present invention, “Suveruyu” (also known as Ihizuru or Dragonfly) means the scientific name Portulaca oleracea L. belonging to the genus Suveruyu, but related plants belonging to the genus can also be used. The purslane is a fleshy, annual plant with reddish brown stems, and is widely distributed in sunny areas along the field and on the roadside, and is easily available.
In the external preparation of the present invention, it is preferable to use whole grass as the purslane.

[Semi-fermented tea]
Tea (Thae sinensis) can be classified into three types: non-fermented tea (green tea), semi-fermented tea (oolong tea), and fermented tea (tea).
These are all made from the leaves of the camellia genus Camellia sinensis, but are usually produced by inactivating the oxidase (polyphenol oxidase) contained in the tea leaves by heating. Non-fermented tea, normal tea produced by fully utilizing enzyme action without heating to the final stage of production, fermented tea, semi-fermented oolong tea produced by the intermediate production method of unfermented tea and fermented tea Called tea.
The “half-fermented tea” in the present invention means “oolong tea” or “pu-er tea”.
Here, “pu'er tea” is a typical black tea made by placing green tea, which has been oxidatively fermented by heating, in a hot and humid place and fermenting it with koji mold for half to two years.

[Red view sky]
In the present invention, “Kokeiten” refers to the plant belonging to the genus Benxiaceae, but related plants belonging to the genus can also be used, and the type and production area are not particularly limited.
Tibetan, Sichuan, and Yunnan provinces of the People's Republic of China are famous as the production areas of the Hongkong genus plants. (Rhodiola euryphylla) and Sekiji Kagekeiten (full valve) (Rhodiola sacra).
Also, there is no particular limitation on the method for preparing the red ginseng genus plant extract. For example, the whole of the red ginseng genus plant, or any one or more of leaves, stems, petals, seeds, rhizomes, roots, etc. Is dried or cut without drying, and then extracted with a solvent at a low temperature or from room temperature to warming.
In addition, it is as follows when the red-viewing genus plant which can be used by this invention is illustrated (illustrated in order of a plant name (scientific name / production area)).
Kikoku Scenic Sky (R.algida / Aomi, Kaihoku, Haisai), Karako Kagekeiten (R.algida var.Tangutica / Aomi, Sichuan), Nishikawa Kagekeiten (R.alsia / Sichuan), Koza Beni Kageten (R.dumulosa / Sichuan, Gansu), Ohana Kageten (R.euryphylla / NW Yun, Tibet), Long Whip Scenic (R.fastigiata / NW Yun, Tibet), Long Scale Kageten (R .gilida / Utenyama), R.henryi / Gansu, Henan, Hubei, Sichuan, Guizhou), Ascension's red view (R.heterodonta / Xinjiang, Tibet), narrow leaf red view (R.henryi) kirillowii / Hebei, Shanxi, Yunnan, Sichuan, Tibet), Shiren Benkeiten (R.quadrifida / Gansu, Qinghai, Xinjiang, Sichuan, Tibet), Koshoku Benkei (R.sachalinensis / Heilongjiang, Jilin) , Red Scenic Spots (All Ben) (R.sacra / Northern Southwest of Clouds, Southeast Tibet), Red Scenic Spots (R.scabrida / Western Sichuan, Northwestern Clouds), Red Scenic Spots (R.wallichiana) / Northern Yunnan, Southeast Tibet), Coarse Coarse Benikeiten (R.wallichiana var. Cholaensis / Qinghai, Yunnan northwest part), Yunnan Benikeiten (R.yunnanensis / Hubei western)

[Park]
In the present invention, the term “Koboku” refers to the Magnolia family Magnoliaceae (Magnolia) plants, Magnolia obovata Thunb., Senboku, Hokukokuboku, Karahoo (Magnolia officinalis Rehd. Et Wils. ), Unboku, Unshokuboku (Magnolia officinalis Rehd. Et Wils. Var. Biloba Rehd. EtWils.), Etc. All plants, flowers, spikes, pericarps, fruits, stems, leaves, branches, Branches, leaves, stems, bark, rhizomes, root barks, roots, seeds or whole grass can be used, but bark is preferably used.
In addition, the same genus species can also be used. Moreover, what dried the bark of Koboku is a kind of herbal medicine called "Koboku", and such herbal medicine can also be used.

[Wiki]
In the present invention, “weather” is a perennial plant belonging to the family Umbelliferae, and each part such as leaves, stems, roots, flowers, fruits and whole plants can be used, but fruits are used. Is preferred. What dried the fruit of a fennel is a kind of crude drug called a "fennel", and such a crude drug can also be used.

[Chen]
“Chimpi” in the present invention is a herbal medicine obtained by drying the mature pericarp of a plant of the Rutaceae citrus genus (Citrus): Citrus unshiu Marcov. Or other related plants. The skin is used as it is or after being crushed. In addition, a skin extract extracted with a solvent may be used. The crust extract is obtained by soaking in an extraction solvent. At the time of immersion, stirring may be performed to increase extraction efficiency, or homogenization may be performed in an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but is suitably about 4 hours to 2 weeks.

[Tissou]
In the present invention, “Tisoiso” is a fruit of jujuba miller var.inermis Rehder or its near-green plant, and jujube is native to Southern Europe and is a small deciduous leaf grown in various parts of Japan. It is Kashiwagi. As the extract (Jujube Extract), an extract extracted with ethanol, 1,3-butylene glycol, purified water or the like can be preferably used.

[Yokuinin]
“Yokuinin” in the present invention means seeds excluding the seed coat of Coix lacryma-jobi L. var. Ma-yuen Stapf (specifically, dried mature seeds without seed coat). Etc.). Here, pearl barley is an annual herb that originates in China and Indochina, has been in Japan for a long time, and is cultivated in the warmer areas of the southwest. It has been used as a herbal medicine with medicinal properties such as analgesia, anti-inflammation and drainage. However, the production area is not particularly limited.
The extract (extract) of Yokuinin used in the present invention can be obtained by extracting from a seed (herbal medicine name: Yokuinin) excluding the seed coat of the genus Jizdama using a suitable solvent (for example, pearl barley). Can be obtained by digestion with water, ethanol or 1,3-butylene glycol and filtration.

[Kuko]
In the present invention, “wolfberry” (scientific name: Lycium chinense) refers to a deciduous shrub of the solanaceae native to China (flowering period is summer to early autumn) that grows naturally on the waterside such as the riverbank.
For the wolfberry extract (extract) in the present invention, any part of the wolfberry fruit, root bark, leaves, stems, roots, flowers, etc. and whole grass may be used. Skin and leaves are preferred.
The fruit, root bark, and leaves of wolfberry are made into herbal medicines such as coconut bark, earth bone bark (jikkopi), and cocoon leaf (Kukoyo). Insulators have a blood pressure and blood sugar lowering action, an anti-fatty liver action, etc., and the ground skin has an anti-inflammatory action, an antipyretic action, etc., and koji leaves have a blood pressure lowering action, etc.
The wolfberry extract of the present invention can be extracted using a suitable solvent.

[Shiny]
In the present invention, “Shinyi” (scientific name: Magnolia liliflora) is a dried magnolia magnolia flower bud (more preferably, early spring, collecting buds with swelled hair before flowering, Except for, it is well-dried in a well-ventilated shade.
Incidentally, the magnoliaceae magnolia plant means tamashiba (Magnolia salicifolia Maximowicz), kobushi (Magnolia kobus De Candolle), or other related plants (Magnoliaceae), and the flower of the magnolia magnolia magnolia of the present invention is dried. ) Can be extracted using a suitable solvent.

[Uronic acid-containing polysaccharide]
The external preparation in the present invention contains "the uronic acid-containing polysaccharide having an average molecular weight of 1,000 to 10,000 and its derivative" shown in (B), in addition to the above-described plant extracts or alone. can do.
However, it is skin aging / drying / various that contains both one or more selected from the plant extracts listed in (A) and one or more selected from the group consisting of substances of (B). It is more preferable to exhibit the effect of preventing the rustling feeling, pruritus feeling or burning feeling caused by skin diseases.
Here, the polysaccharide means a polymer in which about 10 or more monosaccharides are polymerized, and the uronic acid-containing polysaccharide is a polysaccharide containing a carboxyl group derived from seaweed, microorganism, plant or animal, for example, Okinawa mozuku. Examples include fucoidan obtained from the above, alginic acid of brown algae; pectin; mucopolysaccharide (glycosaminoglycan) such as heparin, chondroitin sulfate, hyaluronic acid, and teicuronic acid. Also included are pharmaceutically acceptable salts.
The “uronic acid-containing polysaccharide having an average molecular weight of 1,000 to 10,000” in the present invention means “an oligoalginate obtained by decomposing a polymer alginate with a microorganism or an enzyme” or “Morohaya or Tsurumurasaki”. “Polysaccharide mixture containing oligoalginate obtained by decomposing uronic acid-containing polysaccharide with microorganism or enzyme”.
Examples of derivatives of uronic acid-containing polysaccharides having an average molecular weight of 1,000 to 10,000 include carboxymethyl derivatives, hydroxyethyl derivatives, deacetylated derivatives, and the like. Of these other polysaccharides and their derivatives, chitin, chitosan, alginic acid or carboxymethylcellulose is most preferred.
In the external preparation of the present invention, it is most preferred to use “sodium oligoalginate” as the “uronic acid-containing polysaccharide having an average molecular weight of 1,000 to 10,000 and its derivative” shown in (B).

An external preparation containing at least one selected from the group consisting of the extracts of the plants listed in (A) and the substance (B), and having a pH of 4.5 to 11.0 In the range, the external preparation having an oxidation-reduction potential of 200 mV or less is the external preparation according to the present invention.
Hereinafter, screening methods for extracts and the like having an oxidation-reduction potential of 200 mV or less in the range of pH 4.5 to pH 11.0 will be described.

[Preparation method]
The preparation of each plant extract (Suveruhiyu, semi-fermented tea, Hongjingten, Kobak, fennel, Chen, Taiso, Yokuinin, Kuko, Shinyi extract) is used as described in the above-mentioned column for each plant extract. It can be prepared flexibly considering the dosage form.
That is, extraction can be performed with water alone, a water-soluble solvent such as alcohol or glycol alone, or a mixture of water and a water-soluble solvent.
The pH of the extracted plant extract depends on the pH of the solvent used, the plant material, and the use of acid / alkali.

The method for preparing each plant extract used in the present invention (described above) can be performed, for example, as follows.
1) Add 200 g of ion-exchanged water (redox potential 300 mV) to 5 g of dried plant, boil for 1 hour, cool to room temperature and filter to obtain a plant extract.
2) The pH of the plant extract thus obtained is in the range of 4.5 to 7.5.

The redox potential is measured at slightly acidic, neutral, and alkaline pH, and the change in redox potential due to pH change is measured. If the extract is weakly acidic, the pH is not adjusted, and neutral / alkaline The pH is adjusted with sodium carbonate to pH 7 ± 0.5 and pH 10.
Thus, the extract is measured with an oxidation-reduction potentiometer (manufactured by Sato Shoji Co., Ltd.), and it is determined that the extract showing a potential of 200 mV or less has reducibility.
More preferably, an extract having an oxidation-reduction potential of 200 mV or less is screened and made effective when the pH of the extract is in the range of 5.5 to 8.0.

About the external preparation which uses as an active ingredient any one or more selected from the group which consists of the extract of each plant enumerated in (A), and the substance of (B), as mentioned above, pH4.5 or more and pH11.0 or less In this range, it is effectively used as an external preparation that reduces the irritating and burning sensation caused by sunburn / drying, etc., and the itchiness and burning sensation caused by skin diseases such as insect bites, athlete's foot, and insects. can do.
Among the group consisting of the plant extracts listed in (A) and the substance of (B), the purslane extract, the puer tea extract, the Kobaku extract, the Yokuinin extract, the wolfberry extract, the Shiny extract, the oligo having an average molecular weight of 1,000 to 10,000 Alginates are particularly effective in suppressing rustling and burning sensations caused by sunburn and drying, and itching and burning sensations caused by skin diseases such as insect bites, athlete's foot, and insects.

〔Content〕
Picked from suberuille, semi-fermented tea (Puer tea, oolong tea), Hongjing Ten, Kopak, Fennel, Chen, Taiso, Yokuinin, wolfberry, Shinyi, uronic acid-containing polysaccharides with an average molecular weight of 1,000-10,000 and their derivatives In the external preparation of the present invention, the non-volatile content of one or two or more extracts is preferably added in an amount of 0.001 to 5% by mass, more preferably 0.005 to 2% by mass. .
The reason is that if the amount is less than 0.001% by mass, the effect of the present invention (effect of preventing rustling, pruritus, or hot feeling caused by skin aging / drying / various skin diseases) can be sufficiently exerted. In addition, even if blended in an amount of 5% by mass or more, an effect as expected as compared with an effect within a preferable range cannot be obtained, and therefore it is not preferable in any case.

The topical preparation of the present invention comprises the above-mentioned active ingredients (each plant extract (extracts of purslane, semi-fermented tea, red ginseng, kobaku, fennel, cinnamon, taiso, yokuinin, wolfberry, shinyi) and an average molecular weight of 1,000 to 1. By using a pharmaceutically acceptable pharmaceutical carrier together with 10,000 uronic acid-containing polysaccharides, a conventionally known dosage form can be obtained as an external preparation.
In particular, it is preferable to use dosage forms such as pasta, ointment, cream, liquid, gel, patch, patch, patch and the like.
In addition, according to the above dosage form, preparation and production of the external preparation of the present invention is performed by mixing and homogenizing the above plant extract components and uronic acid-containing polysaccharides and pharmaceutical techniques conventionally used pharmacologically by conventional methods. This can be done.

Among the components used in the preparation and production of the external preparation of the present invention in addition to the above active components, specific examples of the base component include the following components.
Examples of fats include synthetic oils such as medium-chain fatty acid triglycerides and hard fats, olive oil, soybean oil, rapeseed oil, peanut oil, safflower oil, nuka oil, sesame oil, camellia oil, corn oil, menthol oil, coconut oil, etc. Animal oils such as vegetable oil, pork fat, beef tallow, and these hardened oils.
As waxes, for example, natural waxes such as lanolin, beeswax, carnauba wax, and whale wax, mineral waxes such as montan wax, and synthetic waxes can be used.
Examples of the hydrocarbon include petrolatum, simal gel, paraffin, liquid paraffin, microcrystalline wax, squalane, polyethylene powder, and gelled hydrocarbon.
As the higher fatty acid, for example, stearic acid, behenic acid, palmitic acid, oleic acid and the like can be used.
As the higher alcohol, for example, behenyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, cholesterol and the like can be used, and as the polyhydric alcohol, for example, propylene glycol, polyethylene glycol, glycerin, 1,3-butylene glycol and the like Can be mentioned.
Synthetic and natural polymers include, for example, carrageenan, starch, dextrin, dextrin polymer (cadexomer), polyoxyethylene polyoxypropylene glycol (poloxamer) tragacanth, gum arabic, locust bean gum, pectin, gelatin, xanthan gum, pullulan, alginate , Hydroxypropylcellulose, sodium carboxymethylcellulose, polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, and the like can be used.
Examples of the surfactant include alkyl sulfate, polyoxyethylene alkyl ether phosphate, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyethylene glycol fatty acid Esters, polyoxyethylene polyoxypropylene glycols, polyoxyethylene alkyl ethers, sucrose fatty acid esters, and the like can be used.
As the lower alcohol, for example, ethanol, isopropyl alcohol and the like can be used.
Examples of ketones that can be used include acetone and methyl ethyl ketone.
Examples of the powder that can be used include kaolin, talc, zinc oxide, titanium oxide, magnesium stearate, anhydrous silicic acid, and starch.
As the cellulose derivative, for example, methyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose and the like can be used.
Examples of inorganic salts include potassium iodide, sodium iodide, sodium sulfate, sodium bicarbonate, sodium chloride, calcium nitrate, potassium nitrate, sodium nitrate, aluminum sulfate, sodium polyphosphate, ammonium chloride, iron sulfate, sodium phosphate, sulfuric acid. Magnesium, sodium thiosulfate, sodium sesquicarbonate, sodium sulfide, borax, calcium oxide, magnesium carbonate, potassium chloride and the like can be used.

More specifically, the relationship between each dosage form and additive components is as follows.
That is, the pasta agent can be used in the form of an oily pasta agent or an aqueous pasta agent. In the case of an oily pasta agent, for example, fats, waxes, hydrocarbons, etc. are used as base components, and the aqueous pasta agent For example, synthetic and natural polymers, polyhydric alcohols, surfactants and the like can be used as base components.
In the case of an ointment, as a base component, for example, fats, polyhydric alcohols, hydrocarbons and the like can be used.
In the case of a cream, for example, a surfactant, a higher alcohol, a higher fatty acid, a hydrocarbon, a polyhydric alcohol, water (purified water) or the like can be used as a base component.
In the case of liquids and gels, for example, water (purified water), lower alcohols, ketones, fats, polyhydric alcohols, surfactants, hydrocarbons, synthetic and natural polymers are used as base components. be able to.

  Further, in the external preparation of the present invention, an alkali metal hydroxide such as sodium hydroxide may be used as a pH adjuster as necessary, and as an antiseptic / preservative, for example, sodium benzoate or the like. You may mix | blend alkali metal benzoate, paraoxybenzoic acid ester, sorbic acid, phenoxyethanol, etc. Further, if necessary, for example, tocopherol, dibutylhydroxytoluene, butylhydroxyanisole and the like may be used as an antioxidant.

The external preparation of the present invention obtained as described above may be an emulsion-type preparation, but the emulsion may be either W / O type or O / W type.
In addition, the external preparation for skin of the present invention may be applied directly to the skin (affected area). For example, a poultice or the like obtained by applying the external preparation to a stretchable cloth, nonwoven fabric, plastic sheet or the like. You may apply to skin (affected part) as patches, such as a plaster agent.

  The external preparation of the present invention obtained as described above can exhibit a sufficient effect for preventing the rustling feeling, pruritus feeling, or burning feeling caused by skin aging, drying and various skin diseases.

[Use]
The external preparation of the present invention can be used mainly as a skin external preparation, and has the effect of preventing the rustling feeling, pruritus feeling, or burning sensation caused by skin aging / drying / various skin diseases. (Cosmetics), bath preparations, quasi-drugs and the like can also be applied.

  EXAMPLES Hereinafter, although this invention is further demonstrated based on an Example, this invention is not limited only to this Example.

The extract of the present invention was prepared as follows.
In addition, the redox potential of this extract was measured.
(Sample preparation)
(1) 200 g of ion-exchanged water (redox potential 300 mV) was added to 5 g of dried plant, boiled for 1 hour, cooled to room temperature, and filtered to obtain a plant extract.
(2) 50 mg of alginate lyase was added to 100 g of a 5% by weight aqueous solution of sodium alginate having an average molecular weight of about 100,000 and allowed to act at 37 ° C. for 48 hours, followed by filtration to obtain an oligosodium alginate solution having an average molecular weight of about 1,000 to 4,000. Obtained.
The results are shown in [Table 1].

Using the plant extracts listed in [Table 1], external preparations according to the present invention (Examples 1 to 14), and external preparations (Comparative Example 1) as comparative controls were prepared.
Formulation examples are as shown in [Table 2] and [Table 3] described later.

  About the external preparation (Examples 1-14) concerning the above-mentioned this invention and Comparative Example 1, confirmation of the rough feeling suppression of a skin and suppression of a burning feeling was performed. The test of the rustling feeling suppression and the burning sensation suppression was performed as follows.

[Evaluation 1]
Twenty people over 50 years old who had pruritus on both feet after taking a bath.
The application conditions for the extract-containing external preparation are limited to either the left or right foot after taking a bath, and the non-extracted external preparation is applied to each leg each time. The feeling suppression effect was compared, and the suppression effect of the rough feeling was evaluated in five levels. In addition, the feeling of burning was evaluated at the same time as the feeling of rustling, and the effect of suppressing the feeling of burning was evaluated in five stages.
(Judgment class)
1: Less than 20% is effective 2: 20% or more, less than 40% is effective 3: 40% or more, less than 60% is effective 4: 60% or more, less than 80% is effective 5: 80% or more is effective Effective

[Evaluation 2]
A itch suppression test was conducted on insect bites during the summer period, regardless of age.
When a person who was stabbed by an insect felt itching, an external preparation was applied, and the rate at which itching healed within a few minutes was evaluated on a five-point scale. Similarly, the effect of suppressing the feeling of fire was also evaluated in five stages.
(Judgment class)
1: Less than 20% is effective 2: 20% or more, less than 40% is effective 3: 40% or more, less than 60% is effective 4: 60% or more, less than 80% is effective 5: 80% or more is effective Effective

[Evaluation 3]
Regardless of age, during the summer period, we conducted a test to control tingling and burning feelings for sunburned people. The effect of suppressing the tingling sensation was evaluated in five levels. Moreover, the fire suppression feeling suppression effect was evaluated in five stages. However, the self-report was made for the effect assessment for each test item.
(Judgment class)
1: Less than 20% is effective 2: 20% or more, less than 40% is effective 3: 40% or more, less than 60% is effective 4: 60% or more, less than 80% is effective 5: 80% or more is effective Effective

[Discussion]
From the results of Table 2 and Table 3, the external preparations of the present invention (Examples 1 to 14) were superior in comparison with Comparative Example 1 in any of [Evaluation 1] to [Evaluation 3]. Could get.
From the above, it was shown that the external preparation of the present invention can exhibit a sufficient effect for preventing the rustling feeling, pruritus sensation, or burning sensation caused by skin aging, dryness, and various skin diseases.

Claims (6)

Any one or more selected from the group consisting of the plant extract listed in (A) below and the substance (B) is used as an active ingredient, and oxidation is 200 mV or less in the range of pH 4.5 or more and pH 11.0 or less. An external preparation characterized by having a reduction potential.
(A) purslane, semi-fermented tea, red scenic tempura, Kobaku, fennel, Chen, Taiso, Yokuinin, wolfberry, Shinyi (B) uronic acid-containing polysaccharides having an average molecular weight of 1,000 to 10,000 and their derivatives One or more selected from the plant extracts listed in (A) below and one or more selected from the group consisting of the substances of (B) as active ingredients, a range of pH 4.5 or more and pH 11.0 or less And an external preparation characterized by having an oxidation-reduction potential of 200 mV or less.
(A) purslane, semi-fermented tea, red scenic tempura, Kobaku, fennel, Chen, Taiso, Yokuinin, wolfberry, Shinyi (B) uronic acid-containing polysaccharides having an average molecular weight of 1,000 to 10,000 and their derivatives The external preparation according to claim 1 or 2, wherein a content of a nonvolatile content of the active ingredient is 0.001 to 5% by weight. The external preparation according to any one of claims 1 to 3, which contains sodium oligoalginate as the uronic acid-containing polysaccharide (B) having an average molecular weight of 1,000 to 10,000 and its derivative. The external preparation according to any one of claims 1 to 4, wherein the dosage form is any one selected from the group consisting of pasta, ointment, cream, liquid, gel, patch, patch, and patch. . The external preparation according to any one of claims 1 to 5, which is in the form of a cosmetic.