CN110251448A - A kind of cosmetic compositions containing propolis extract - Google Patents
A kind of cosmetic compositions containing propolis extract Download PDFInfo
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- CN110251448A CN110251448A CN201910573845.2A CN201910573845A CN110251448A CN 110251448 A CN110251448 A CN 110251448A CN 201910573845 A CN201910573845 A CN 201910573845A CN 110251448 A CN110251448 A CN 110251448A
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- extract
- cosmetic compositions
- german chamomile
- propolis
- ceylon cinnamon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
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- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
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- Cosmetics (AREA)
Abstract
The present invention relates to a kind of cosmetic compositions, including propolis extract, german chamomile extract, Ceylon cinnamon extract and retinol；The invention also discloses the preparation methods of above-mentioned cosmetic compositions.Technical solution of the present invention is by being added propolis extract, german chamomile extract, Ceylon cinnamon extract and retinol, skin collagen can be stimulated to generate, promote skin self-repairing capability, it is provided simultaneously with the effect that anti-inflammatory is releived, effective component can be promoted to play a role.
Description
Technical field
The invention belongs to cosmetics and skincare product technical fields, and in particular to a kind of cosmetic compositions.
Background technique
German chamomile is distributed in Xinjiang, China the north and western river valley wilderness, Tian Bian.German chamomile capitulum can be used as medicine, and have sweating
It is acted on antispastic.German chamomile herb contains a large amount of vitamin A and C.German chamomile is a kind of fragrant plant, also there is ornamental value.20
Before century 70, people have started the research to the active constituent of german chamomile.Research finds that german chamomile inflorescence contains more than 120 kinds
Chemical component, including 28 kinds of terpenoid substances, 36 type Flavonoid substances and 52 kinds of other materials, such as organic acid, tonka-bean
Element etc..German chamomile herb and flower contain volatile oil, and herb contains 0.46%-0.67%, in oil containing blue sesame oil Azulene and former Azulene, farnesene,
Bisabolol, Bisabolol terpene alcohol oxide etc..Flos Chrysanthemi containing choline, apiolin etc., spend middle mucilaginous substance have galactolipin thuja acid,
Galactolipin, xylose and polysaccharide etc..Its extract has more application in beauty treatment fields at present.
Ceylon cinnamon originates in Sri Lanka's West India seashore.Chinese Guangdong, Guangxi, Yunnan, Fujian, zhejiang and other places draw
There are cultivation in kind cultivation, Tropical Asia various countries more.Bark and branch, the Ye Junhan aromatic oil of Ceylon cinnamon, cloves contained in leaf oil
Phenol can be used for synthesizing vanillic aldehyde, and Ergol is natural fixastive, also acts as the solvent of a variety of essence, is especially used as
The solvent of synthetic musk；It is used as the raw material of the drugs such as anti-corrosion, stomach invigorating, convergence sterilization and tonic in medicine；Medical value is high.
Propolis is the natural gum that honeybee acquires from petal, tree bud, in conjunction with the formation such as the mandibular gland secretion of honeybee and beeswax
The colloidal solid object with special aromatic odor.Propolis is known as the title of " purple gold ", and main active constituent is flavones
Class, organic acid, terpenes, aromatic aldehydes, esters and a variety of amino acid, vitamin, minerals etc., have it is antibacterial, antiviral,
Anti-oxidant, cancer-resisting adjusts the physiological functions such as immunity, while propolis is for oral administration, adjustable hyperlipidemia, hypertension etc., in advance
The formation of anti-atherosclerosis and thrombus is known as " street cleaner of blood ".Propolis is also referred to as the " treasured of flavone compound
Library ", mainly includes flavones, flavonols, flavanols, phenolic acid etc., wherein 5- hydroxyl -5- 4,7- dimethoxy flavanone and 5,
7- dihydroxy -3,4- dimethoxy flavone is the endemic element of propolis, the physiology and pharmacological activity of most of propolis all with this
Class compound is related.The antioxidant activity of flavone compound and its molecular structure are closely bound up, on flavone compound B ring
3,4- dihydroxy are its key positions for removing free radical, and the hydroxyl on other rings can increase its anti-oxidant effect to some extent
Fruit.Free radical is the normal metabolite of organism, under normal circumstances in the dynamic equilibrium for generating and removing；Oxidative stress
Under the conditions of can lead to the oxidative damage of body, cause the diseases such as aging, inflammation, cancer, propolis flavone have it is preferable freely
Base scavenging capacity.
Vitamin A is fat-soluble alcohols material, there are many molecular forms, wherein VA1It is primarily present in animal's liver, blood
In the retina of liquid and eyeball, be called retinol, have effects that adjust epidermis and cuticula metabolism, can with anti-aging,
Wrinkle is removed, seborrhea is can be reduced and keeps skin flexible, while Kohakuhi, soft and moist skin；Help to protect epidermis, mucous membrane
Not by bacterial infestation, healthy skin prevents cutaneum carcinoma.But there are certain irritations to skin for retinol, therefore in cosmetics
Usual additive amount is lower, safety and validity is more difficult takes into account, and oxidizable rotten.It is incompetent in existing product preferably to solve
State the formula of problem.
Summary of the invention
It include propolis extract, german chamomile extract, Ceylon cinnamon extract and view the purpose of the present invention is to provide one kind
The cosmetic compositions of flavol, for stimulating skin collagen to generate, promoting skin self-repairing capability, while for shakiness
The skin for determining state carries out anti-inflammatory and releives.
The present invention to achieve the above object the technical solution adopted is that: a kind of cosmetically combination containing propolis extract
Object, including propolis extract, german chamomile extract, Ceylon cinnamon extract and retinol；
Further, the german chamomile extract is the extract of german chamomile herb and flower；
Further, the Ceylon cinnamon extract is Ceylon cinnamon leaf extract；
Further, in the composition propolis extract, german chamomile extract, Ceylon cinnamon extract and retinol weight
Amount is than being 5~10:1~5:1~5:1-3；
Further, the german chamomile extract the preparation method comprises the following steps: german chamomile herb and flower are cleaned and shreds, are dehydrated, use
It is equivalent to nonpolar solvent refluxing extraction 1-2 times of german chamomile herb and 1-3 times of weight of flower, concentrates filtrate to paste, then
German chamomile extract is obtained through dewaxing, desolventizing, recycling design；
Further, the nonpolar solvent is the petroleum ether that boiling range is 60-90 DEG C；
Further, the propolis extract the preparation method comprises the following steps: by propolis raw material low-temperature grinding, being placed in deionized water
And dispersing agent is added, it is stirring evenly and then adding into inorganic salt solution, is dissolved in non-face after cooling and standings, removing solid after heating and stirring
Heating pressurization extraction 2-7 hours in boundary's fluid solvent, are evaporated under reduced pressure simultaneously recycling design, obtain propolis extract；
Further, the Ceylon cinnamon extract the preparation method comprises the following steps: Ceylon cinnamon leaf is cleaned and is shredded, gained is broken
Blade adds the alcohol that carbon atom number is 2-6 to mix, refluxing extraction 1-2 times, and merging filtrate is concentrated under reduced pressure to give Ceylon cinnamon extraction
Object extract.
Cosmetics, which are used to prepare, the present invention also provides cosmetic compositions as described above obtains purposes；
Further, the cosmetics further include the acceptable auxiliary material of cosmetic art；
Further, the acceptable auxiliary material of the cosmetic field is selected from: solvent, solubilizer, preservative, antioxidant, pH
Regulator, penetrating agent, liposome, moisturizer, thickener, chelating agent, skin sense regulator, surfactant, emulsifier, propulsion/
Propellant, essence, pigment and other functional additives.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
(1) retinol can prevent pachylosis, stimulation skin collagen from generating, while energy
Kohakuhi, but it is larger to skin irritation, and sensitive skin is not available retinol to realize and subtract light wrinkle
Effect, and reduction retinol sensitization and irritation are realized by the way that a variety of natural extracts are added in the application, while can mention
The transdermal absorption factor of high retinol；
(2) german chamomile herb and the vitamin C being rich in spending are natural antioxidants, can be delayed by removing free radical
Aging, and can anti-radiation and ultraviolet light；Its vitamin A being rich in also has protection to skin and accelerates the work of metabolism simultaneously
With；The bisabolol and its derivative contained in german chamomile has antiphlogistic antibacterial effect, can make cosmetically combination of the invention
Object is used to prepare the antibacterial additives that use when skin care item or cosmetics and reduces, ingredient more it is natural mildly, bisabolol and its
Derivative and retinol synergistic effect have better antioxidant effect；
(3) extract in Ceylon cinnamon leaf can inhibit with stronger sterilizing power and have antisepsis, Ceylon cinnamon
The smell of leaf extract is pleasant, can reduce cosmetic compositions of the invention is used to prepare the virtue used when skin care item or cosmetics
Pastil.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment 1
A kind of cosmetic compositions, propolis extract, german chamomile extract, Ceylon cinnamon extract and view in the composition
The weight ratio of flavol is 10:5:3:2.
The preparation step of cosmetic compositions are as follows:
1) preparation of Ceylon cinnamon leaf extract: cleaning Ceylon cinnamon leaf and shred, and the broken blade of gained adds 2 times of weight
Dehydrated alcohol mix, 80 DEG C refluxing extraction 2 times, 1 1h, merging filtrate is concentrated under reduced pressure to give Ceylon cinnamon leaf extract；
2) preparation of german chamomile herb and flower extract: german chamomile herb and flower clean and shred, are dehydrated, and addition is equivalent to german chamomile
The petroleum ether that the boiling range of herb and 3 times of weight of flower is 60-90 DEG C, refluxing extraction 2 times, 1 1h, after the filtrate filtering after merging
It is concentrated under reduced pressure into paste in vacuum degree -0.090MPa, the dehydrated alcohol of 4 times of volumes of paste is added, after being sufficiently stirred, puts
2 hours, filtering are set, is freezed 24 hours after filtering out wax, heat preservation filters out wax, and the liquid after dewaxing is poured into Rotary Evaporators
In, constant temperature water bath heating Rotary Evaporators to 50 DEG C of desolventizings, recycling design obtains german chamomile herb and flower extract；
3) preparation of propolis extract: -5 DEG C of propolis raw material are crushed, be placed in the deionized water of 2 times of its quality and are added
The propylene glycol alginate and polyoxyethylene sorbitan monolaurate mass ratio that 0.01 times of propolis raw material quality are the mixed of 2:0.3
Close object, be stirring evenly and then adding into 0.5 times of propolis raw material quality mass fraction be 60% sodium bicarbonate aqueous solution, until 50 DEG C simultaneously
30min is stirred, stands 0.5h after being cooled to 25 DEG C, to be dissolved in the matter of 1 times of its quality after 3000r/min refrigerated centrifuge removing solid
Measure score be 90% ethanol water in, 50 DEG C, 0.2MPa extraction 5h after be evaporated under reduced pressure and recycle ethyl alcohol, obtain propolis extraction
Object；The propolis extract general flavone content that this method is extracted is high, and (general flavone content is up to 300mgg-1), content of beary metal it is low；
4) propolis extract, german chamomile extract, Ceylon cinnamon extract and retinol are mixed by weight for 10:5:3:2
It closes, the pH of mixture is adjusted to 6 and obtains product cosmetic compositions.
Embodiment 2
A kind of cosmetic compositions, propolis extract, german chamomile extract, Ceylon cinnamon extract and view in the composition
The weight ratio of flavol is 5:3:3:2.
The preparation step of cosmetic compositions are as follows:
1) preparation of Ceylon cinnamon leaf extract: cleaning Ceylon cinnamon leaf and shred, and the broken blade of gained adds 2 times of weight
Dehydrated alcohol mix, 80 DEG C refluxing extraction 2 times, 1 1h, merging filtrate is concentrated under reduced pressure to give Ceylon cinnamon leaf extract；
2) preparation of german chamomile herb and flower extract: german chamomile herb and flower clean and shred, are dehydrated, and addition is equivalent to german chamomile
The petroleum ether that the boiling range of herb and 3 times of weight of flower is 60-90 DEG C, refluxing extraction 2 times, 1 1h, after the filtrate filtering after merging
It is concentrated under reduced pressure into paste in vacuum degree -0.090MPa, the dehydrated alcohol of 4 times of volumes of paste is added, after being sufficiently stirred, puts
2 hours, filtering are set, is freezed 24 hours after filtering out wax, heat preservation filters out wax, and the liquid after dewaxing is poured into Rotary Evaporators
In, constant temperature water bath heating Rotary Evaporators to 50 DEG C of desolventizings, recycling design obtains german chamomile herb and flower extract；
3) preparation of propolis extract: -5 DEG C of propolis raw material are crushed, be placed in the deionized water of 2 times of its quality and are added
The propylene glycol alginate and polyoxyethylene sorbitan monolaurate mass ratio that 0.01 times of propolis raw material quality are the mixed of 2:0.3
Close object, be stirring evenly and then adding into 0.5 times of propolis raw material quality mass fraction be 60% sodium bicarbonate aqueous solution, until 50 DEG C simultaneously
30min is stirred, stands 0.5h after being cooled to 25 DEG C, to be dissolved in the matter of 1 times of its quality after 3000r/min refrigerated centrifuge removing solid
Measure score be 90% ethanol water in, 50 DEG C, 0.2MPa extraction 5h after be evaporated under reduced pressure and recycle ethyl alcohol, obtain propolis extraction
Object；The propolis extract general flavone content that this method is extracted is high, and (general flavone content is up to 300mgg-1), content of beary metal it is low；
4) propolis extract, german chamomile extract, Ceylon cinnamon extract and retinol are mixed by weight for 5:3:3:3
It closes, the pH of mixture is adjusted to 6 and obtains product cosmetic compositions.
Embodiment 3
Test is compared to the effect of the cosmetic compositions of embodiment 1-2, following group is set altogether:
A1Group: glycerol 4g, xanthan gum 0.1g, carbomer 0.1g, 1,3 butylene glycol 4.3g, glycine betaine 1g are uniformly mixed
And 60 DEG C are heated to, and it is cooled to 40 DEG C (not destroying active constituent) and the cosmetic compositions 0.5g that embodiment 1 obtains is added, stirring
Uniformly obtain applicator；
A2Group: applicator is prepared according to the above method using the cosmetic compositions that embodiment 2 obtains；
B1Group: glycerol 4g, xanthan gum 0.1g, carbomer 0.1g, 1,3 butylene glycol 4.3g, glycine betaine 1g are uniformly mixed
And 60 DEG C are heated to, 40 DEG C of addition retinol 0.6g are cooled to, pH to 6 is adjusted, is uniformly mixing to obtain applicator；
B2Group: glycerol 4g, xanthan gum 0.1g, carbomer 0.1g, 1,3 butylene glycol 4.3g, glycine betaine 1g are uniformly mixed
And 60 DEG C are heated to, 40 DEG C of addition retinol 0.6g and glucocorticoid 0.15g are cooled to, pH to 6 is adjusted, stirs evenly
To applicator；
1 Piglet s colibacillosis of table
*It is detected, is tested micro- according to " cosmetics health specification " (2007 editions) Part IV " Micro biological Tests method "
Biology is staphylococcus aureus or Escherichia coli or its Mixed Microbes.
It does not easily lead to skin allergy and redness it can be seen that cosmetic compositions of the invention have, retinol can be promoted
The effect that effective stimulus skin collagen generates and flesh bottom is repaired, without additionally adding excessive preservative, antibacterial agent, mitigation makes
User's skin burden, facilitates the maintenance of skin barrier.
Simply to illustrate that technical concepts and features of the invention, its purpose is allows in the art above-described embodiment
Those of ordinary skill cans understand the content of the present invention and implement it accordingly, and it is not intended to limit the scope of the present invention.It is all
It is changes or modifications equivalent made by the essence of content according to the present invention, should be covered by the scope of protection of the present invention.
Claims (10)
1. a kind of cosmetic compositions containing propolis extract, which is characterized in that including propolis extract, german chamomile extract,
Ceylon cinnamon extract and retinol.
2. a kind of cosmetic compositions as described in claim 1, which is characterized in that the german chamomile extract be german chamomile herb and
Colored extract.
3. a kind of cosmetic compositions as described in claim 1, which is characterized in that the Ceylon cinnamon extract is Ceylon's meat
Osmanthus leaf extract.
4. a kind of cosmetic compositions as described in claim 1, which is characterized in that propolis extract, mother in the composition
The weight ratio of chrysanthemum extract, Ceylon cinnamon extract and retinol is 5 ~ 10:1 ~ 5:1 ~ 5:1-3.
5. a kind of cosmetic compositions as described in claim 1, which is characterized in that the preparation method of the german chamomile extract
Are as follows: german chamomile herb and flower are cleaned and shredded, is dehydrated, is returned with the nonpolar solvent for being equivalent to german chamomile herb and 1-3 times of weight of flower
Stream extracts 1-2 times, concentrates filtrate to paste, then obtain german chamomile extract through dewaxing, desolventizing, recycling design.
6. a kind of cosmetic compositions as claimed in claim 5, which is characterized in that the nonpolar solvent is that boiling range is
60-90 DEG C of petroleum ether.
7. a kind of cosmetic compositions as described in claim 1, which is characterized in that the preparation method of the propolis extract
Are as follows: by propolis raw material low-temperature grinding, it is placed in deionized water and is added dispersing agent, inorganic salt solution is stirring evenly and then adding into, adds
Heating pressurization extraction 2-7 hours in non-critical fluid solvent are dissolved in after heat and stirring after cooling and standings, removing solid, are evaporated under reduced pressure
And recycling design, obtain propolis extract.
8. a kind of cosmetic compositions as described in claim 1, which is characterized in that the preparation side of the Ceylon cinnamon extract
Method are as follows: Ceylon cinnamon leaf is cleaned and shredded, the broken blade of gained adds the alcohol that carbon atom number is 2-6 to mix, refluxing extraction 1-2 times,
Merging filtrate is concentrated under reduced pressure to give Ceylon cinnamon extract extract.
9. a kind of cosmetic compositions as described in claim 1, which is characterized in that can be used for preparing cosmetics；Preferably, institute
Stating cosmetics further includes the acceptable auxiliary material of cosmetic art.
10. a kind of application of cosmetic compositions as claimed in claim 9, which is characterized in that the cosmetic field can connect
The auxiliary material received is selected from: solvent, solubilizer, preservative, antioxidant, pH regulator, penetrating agent, liposome, moisturizer, thickener,
Chelating agent, skin sense regulator, surfactant, emulsifier, propulsion/propellant, essence, pigment and the addition of other effects
Agent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910573845.2A CN110251448A (en) | 2019-06-28 | 2019-06-28 | A kind of cosmetic compositions containing propolis extract |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910573845.2A CN110251448A (en) | 2019-06-28 | 2019-06-28 | A kind of cosmetic compositions containing propolis extract |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403893A (en) * | 2019-08-06 | 2019-11-05 | 江苏蜂奥生物科技有限公司 | A kind of mildy wash containing propolis extract |
| CN112156060A (en) * | 2020-11-12 | 2021-01-01 | 云南润嘉药业有限公司 | Propolis wash-free long-acting antibacterial gel and preparation method thereof |
| CN113318056A (en) * | 2021-05-28 | 2021-08-31 | 广州伊尔美生物科技有限公司 | New-born beautifying, firming and wrinkle-removing composition, preparation method thereof and firming and wrinkle-removing cream |
| CN115252527A (en) * | 2022-06-15 | 2022-11-01 | 上海创元化妆品有限公司 | Preparation method and application of propolis treatment powder |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105407870A (en) * | 2013-07-25 | 2016-03-16 | 詹尼克公司 | Organogel composition and organogel mask pack produced by using same |
| CN107773503A (en) * | 2016-08-23 | 2018-03-09 | 周国萍 | A kind of bath oil rich in plant extraction elite |
-
2019
- 2019-06-28 CN CN201910573845.2A patent/CN110251448A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105407870A (en) * | 2013-07-25 | 2016-03-16 | 詹尼克公司 | Organogel composition and organogel mask pack produced by using same |
| CN107773503A (en) * | 2016-08-23 | 2018-03-09 | 周国萍 | A kind of bath oil rich in plant extraction elite |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403893A (en) * | 2019-08-06 | 2019-11-05 | 江苏蜂奥生物科技有限公司 | A kind of mildy wash containing propolis extract |
| CN112156060A (en) * | 2020-11-12 | 2021-01-01 | 云南润嘉药业有限公司 | Propolis wash-free long-acting antibacterial gel and preparation method thereof |
| CN113318056A (en) * | 2021-05-28 | 2021-08-31 | 广州伊尔美生物科技有限公司 | New-born beautifying, firming and wrinkle-removing composition, preparation method thereof and firming and wrinkle-removing cream |
| CN115252527A (en) * | 2022-06-15 | 2022-11-01 | 上海创元化妆品有限公司 | Preparation method and application of propolis treatment powder |
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Application publication date: 20190920 |