JP2003073223A - Preparation for external use and flavoring agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a preparation for external use having a good fragrance without an off-flavor of other ingredients and having an excellent feeling of use. SOLUTION: This preparation for external use comprises an ingredient derived from an oroblanco fruit. The preparation preferably comprises a steam distilled substance of the oroblanco fruit or an extract from the oroblanco fruit with water and/or a water-soluble solvent as the ingredient derived from the oroblanco fruit.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel flavoring agent applicable to external preparations such as skin cosmetics, hair cosmetics, oral hygiene and bath agents, and external preparations containing the flavoring agents. .

[0002]

2. Description of the Related Art Oroblanco (product name: Oroblanco, product name: Sweety) is 195.
This plant was established in 1988 by Dr. Soust and Dr. Cameron of the University of California as a hybrid between acid-free Bundan and grapefruit, and is characterized by containing a large amount of essential oil and naringin. Since the sugar content is higher than that of grapefruit, the import amount has increased in recent years for food, but it has not been effectively used for other purposes.

On the other hand, recently, there is an increasing tendency to attach importance to safety regarding raw materials such as cosmetics. Since the safety of ingredients that have been eaten is widely recognized, attempts to apply these ingredients to cosmetics have been actively made. Further, especially for a material having aromaticity, since the scent may have a physiological effect, it is particularly expected to be effective when incorporated into a cosmetic.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide an external preparation having a good fragrance and an excellent feeling in use. Another object of the present invention is to provide a novel flavoring agent which is highly safe and can be used for applications requiring high safety such as medicines such as medicines and quasi drugs, and cosmetics.

[0005]

Means for Solving the Problems The present inventor has conducted various studies on the fruit of Oro Branco, which was conventionally mainly used for food, and as a result, the Oro Branco fruit-derived component has a high aromaticity, It has been found that the compound can be stably incorporated into medicines such as medicines and quasi-drugs, cosmetics and the like, and the present invention has been completed based on this finding. That is, the present invention provides an external preparation containing an Oro Blanco fruit-derived component. As a preferred embodiment of the present invention, an external preparation containing an extract of Oro Blanco fruit as the Oro Blanco fruit-derived component is provided. As a further preferred embodiment of the present invention, as the Oro Blanco fruit-derived component, an external preparation containing a steam distillate of Oro Blanco fruit; as the Oro Blanco fruit-derived component, an external preparation containing an extract of Oro Blanco fruit with water and / or a water-soluble solvent Will be provided. The present invention also provides an external preparation containing a component derived from Oro Blanco fruit as a flavoring agent.

In the present specification, the term "external preparation" is to be interpreted in its broadest sense, and external medicines such as pharmaceuticals and quasi-drugs applicable to the whole body skin including scalp, hair and oral endothelium. And cosmetics. More specifically, it is used as a concept that includes all ointments, basic cosmetics, skin cleansing agents, hair cosmetics, makeup cosmetics, bath agents, oral hygiene agents, dental cleaning agents, and the like.

[0007] From another point of view, a flavoring agent comprising an ingredient derived from Oro Blanco fruit is provided. As a preferred embodiment of the present invention, a flavoring agent comprising an extract of Oro Blanco fruit is provided. As a further preferred embodiment of the present invention, there is provided a flavoring agent comprising a steam distillate of Oro Blanco fruit or an extract of Oro Blanco fruit with water and / or a water-soluble solvent. According to the present invention, the flavoring agent for external preparation is provided.

From another point of view, a method for perfuming an external preparation, which comprises a step of adding a component derived from Oro Blanco fruit to the external preparation; a method for masking the dough odor (raw material odor) of the external preparation. And a method comprising the step of adding a component derived from Oro Blanco fruit to an external preparation; and use of the component derived from Oro Blanco fruit for the production of the external preparation.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The Oro blanco used in the present invention is a diploid acid-free buntan (Citrus grandi).
s) and grapefruit (Citrus paradi)
It is a hybrid of si). The present invention uses the fruit of Oro Blanco, known under the trade name "Sweetie". The component derived from the Oro blanco fruit used in the present invention may be any component contained in the Oro blanco fruit, and examples thereof include components obtained from pulp, fruit juice, pericarp and the like, or a mixture thereof.

In the present invention, a component derived from the fruit of Oro Blanco is used. The Oro Blanco fruit-derived component may be collected by any method, but in terms of stability over time,
Further, it is preferably a steam distillate of Oro Blanco fruit or an extract with water and / or a water-soluble solvent, since it does not cause precipitation when blended in an external preparation such as cosmetics and can be stably blended. . In general, when a plant-derived component is simply added to an external preparation such as a cosmetic, inconveniences such as precipitation may occur over time. However, components derived from Oro Blanco fruit, particularly steam distillate, and water and / or Alternatively, an extract with a water-soluble solvent does not have such a defect.

The "steam distillate" of Oro blanco fruit refers to a distillate obtained by subjecting Oro blanco fruit to steam distillation. The distillate usually contains an essential oil component layer and a water-soluble component layer, but it is preferable to use the water-soluble component layer because it can be stably blended with an external preparation such as cosmetics. Steam distillation can be performed according to a conventional method. When the water-soluble component layer is used, it can be used after being purified by filtration or the like after being separated from the essential oil component layer.

[0012] The "water and / or water-soluble solvent extract" of Oroblanco fruit refers to a product obtained by extracting Oroblanco fruit with water, a water-soluble solvent, or a mixed solvent of water and a water-soluble solvent. Say. As the water-soluble solvent, alcohols (methanol, ethanol, 1,3-
Butylene glycol, propylene glycol and the like), acetone and the like. One or two of these water-soluble solvents may be used.
One or more species may be used sequentially or as a mixture, or as a mixture with water. The extraction can be performed at room temperature or by heating.

The component derived from Oro blanco fruit used in the present invention may be in any form such as liquid, paste and gel. The derived component obtained in a liquid form or the like may be in a solid form which is dried and solidified, or a powder form which is dried by spray drying or the like.

The Oro Blanco fruit-derived components, particularly the steam distillate and the extract with water and / or a water-soluble solvent, can be used as they are as a flavoring agent. Also,
Furthermore, if necessary, an antiseptic / antifungal agent (ethanol; phenoxyethanol; paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, etc.) may be added and used.
Further, after adding an antiseptic / antifungal agent, the antiseptic / antifungal agent may be stored at a low temperature for one to two days and night, and optionally filtered before use. Further, it can be used after being concentrated or diluted.
For dilution, ethanol, 1,3-butylene glycol,
Glycerin, propylene glycol, purified water or the like can be used.

Since the ingredients derived from Oro blanco are highly safe and excellent in stability, they are blended in external medicines requiring high safety such as various medicines, quasi drugs, cosmetics and the like. be able to. In particular, the Oro Branco fruit-derived ingredients are external medicines and basic cosmetics such as lotions, emulsions, creams, ointments, oils and packs; facial cleansers and body cleansers; shampoos, rinses, hair treatments, hair tonics, hair styling products. Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, etc .; solid, granular or liquid bath agents; and toothpaste (dental washing);
It is preferably added to oral hygiene products such as mouthwash;

The method for adding the Oro Blanco fruit-derived component is not particularly limited, and it may be added to the base in advance, or may be added during the mixing of various components. Various conditions such as the timing of the addition can be selected. In addition, when the Oro blanco fruit-derived component is contained in a bath agent, the liquid Oro blanco fruit-derived component is sprayed onto particles serving as a core of anhydrous sodium sulfate, anhydrous magnesium sulfate or the like and blended in a dried form. You can also do it.

The external preparation of the present invention is characterized by containing a component derived from Oro Blanco fruit. The external preparation of the present invention containing an ingredient derived from Oro blanco fruit is stable for a long period of time, has good aromaticity and high safety, and
It is also excellent in usability. For example, when a steam distillate or an extract with water and / or a water-soluble solvent is used as the Oro Blanco fruit-derived component, it can be directly added to the external preparation as it is or after dilution. For example, the steam distillate and / or the extract with water and / or a water-soluble solvent can be used as a substitute for the purified water and the ordinary water to be blended in the conventional formulation of the external preparation. Therefore, its content is not particularly limited.

Ingredients derived from Oro Blanco fruit, preferably
Oro Branco fruit extract contains essential oils, sugars, AHA
It contains various components derived from Oro Blanco such as (α-hydroxy acid) and vitamin C. In particular, the steam distillate contains a large amount of aromatic components derived from the essential oil component, and an aroma giving a unique refreshing sensation drifts faintly over a long period of time. Therefore, the Oro blanco fruit-derived component is useful not only as a flavoring agent, but also as a masking agent for other raw material components for external preparations having an odor compounded in the external preparation, for example.

Further, since many components can be extracted from the Oro blanco fruit-derived component, preferably the extract as described above, the effect of those products can be obtained by adding them to external preparations such as cosmetics for various purposes. Can be compensated for and further enhanced. For example, various extract components such as AHA and vitamin C derived from Oro blanco fruit can complement the whitening effect and enhance the effect as an anti-aging and anti-wrinkle agent. In addition, the essential oil component of Oro blanco fruit has an antibacterial action, and it is effective to mix it with acne and dandruff products.

The external preparation of the present invention contains, if necessary, components that are usually used in the preparation of cosmetics, quasi drugs, and external medicines, to the extent that the effects of the present invention are not impaired, that is,
Water (purified water, normal water, hot spring water, deep water, etc.), alcohols,
Oil agents, surfactants, powders, thickeners, UV inhibitors, antibacterial agents, flavoring agents, pH adjusting agents, cooling agents, plant / animal / microorganism derived extracts, blood circulation promoters, astringent agents, antiseborrheic agents , Whitening agent,
One or more kinds of anti-inflammatory agents, anti-wrinkle agents, active oxygen scavengers, antioxidants, cell activating agents, moisturizing agents, chelating agents and the like can be added. Specific examples of suitable components include those shown below.

Examples of alcohols include lower alcohols such as ethanol, glycerin, diglycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, and other polyhydric alcohols.
Or the mixture thereof is mentioned.

As the oily agent, is it a natural oil as long as it is used for ordinary cosmetics, quasi-drugs and external medicines for improving the constituents or usability and feeling of use of the base. , Synthetic oil, solid, semi-solid or liquid, liquid paraffin,
Hydrocarbons such as squalane, waxes such as beeswax and carnauba wax, fatty acids, higher alcohols, esters of fatty acids and higher alcohols, oils and fats such as lanolin, silicone oils, fluorinated oils, etc., or a mixture thereof. Can be used.

Examples of the surfactant include anionic, cationic, nonionic and amphoteric surfactants, and examples of the anionic surfactant include fatty acid soap, alkyl ether carboxylic acid, alkyl sulfonate and alkyl. Sulfate ester salts, alkyl phosphates, ether phosphates, alkyl allyl ether phosphates, amide phosphates, N-acyl amino acid surfactants, etc .; as cationic surfactants, alkyl amine salts, alkyl quaternary ammonium Salt, aromatic quaternary ammonium salt, pyridinium salt,
Imidazolium salts and the like; as nonionic surfactants,
Sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, poly Oxyalkylene-modified organopolysiloxane, alkanolamide, sugar ether, sugar amide and the like; amphoteric surfactants include betaine, aminocarboxylic acid salts, imidazoline derivatives and the like, or a mixture thereof.

As the thickener, a water-soluble polymer; a water-soluble polymer is used for stabilizing the system, improving usability and usability, or for obtaining a moisturizing effect. Specific examples of water-soluble polymers include carrageenan, pectin, agar, plant-based polymers such as locust bean gum, microbial-based polymers such as xanthan gum, animal-based polymers such as casein and gelatin, and starch-based polymers such as starch. , Cellulose-based polymers such as methyl cellulose, ethyl cellulose, carboxymethyl cellulose and hydroxypropyl cellulose, alginic acid-based polymers such as sodium alginate, and vinyl-based polymers such as carboxyvinyl polymer. Other thickeners; dextrin fatty acid esters such as dextrin palmitate, dextrin stearate, dextrin 2-ethylhexanoic acid palmitate, sucrose palmitate, sucrose stearate esters, etc., mono Examples thereof include benzylidene derivatives of sorbitol such as benzylidene sorbitol, dibenzylidene sorbitol, organic modified clay minerals such as dimethylbenzyl dodecyl ammonium montmorillonite clay, dimethyl dioctadecyl ammonium montmorillonite clay, and mixtures thereof.

As the powder, if it is used in ordinary cosmetics, quasi-drugs and external medicines, its shape (spherical shape, needle shape, plate shape, etc.), particle diameter (fumes, fine particles, pigments) Grade) and particle structure (porous, non-porous, etc.)
Either one can be used. For example, as inorganic powder, talc, mica, sericite, silicic acid anhydride, etc .; as organic powder, polyethylene powder, silk powder, nylon powder, etc .; as colored pigment, iron black, inorganic black such as carbon black Pigments, inorganic blue pigments such as navy blue and ultramarine blue, tar pigments laked, natural pigment laked, etc .; Pearl pigments include titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated talc, fish scales. Examples of the metal powder pigments include foils and the like; powders selected from aluminum powder, copper powder, stainless powder and the like; tar pigments and the like; natural pigments and the like, or a mixture thereof. Further, a powder obtained by compounding these powders or a powder surface-treated with an oil agent, silicone or a fluorine compound may be used.

As the anti-UV agent, 2-ethylhexyl paramethoxycinnamate, 4-tert-butyl-
4'-methoxydibenzoylmethane, oxybenzone and its derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt Etc.), titanium oxide, zinc oxide and the like, or a mixture thereof. Further, if the powder is fine particles, a higher effect is exhibited.

Examples of the antibacterial agent include benzoic acid, sodium benzoate, paraoxybenzoic acid ester, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol and the like, or a mixture thereof.

Examples of the pH adjusting agent include lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid and salts thereof, potassium carbonate, sodium hydrogen carbonate, ammonium hydrogen carbonate and the like, or a mixture thereof. Examples of the cooling agent include L-menthol, camphor and the like, or a mixture thereof.

The blood circulation promoters include nonyl acid warenylamide, capsaicin, zingerone, cantharisin tincture,
Examples thereof include ictamol, α-borneol, inositol hexanicotinate, cyclanderate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthin, γ-oryzanol, and the like, or a mixture thereof. Examples of the skin astringent include tannic acid and the like,
Examples of antiseborrheic agents include sulfur and thiantol.

As whitening agents, vitamin C and its derivatives (L-ascorbic acid phosphoric acid ester, L-ascorbic acid sulfuric acid ester, L-ascorbyl dipalmitate, L-ascorbyl tetraisopalmitic acid, etc.), carotenoids (carotene, Lycopene, astaxanthin, etc.), agarose, oligosaccharides, neoagarobiose, hydroquinone and its derivatives, cysteine and its derivatives, placenta extract, glabridin, glabrene, liquiritin, isoliquiritin, and licorice extract containing these, Yokuinin (pearl barley). Extract,
Scutellaria baicalensis extract, seaweed extract (kelp,
Mackerel, wakame, hijiki, hibamatata, shimeji, trowel, swordfish, vine sparrow, chigaiso, hondarawa,
Brown algae such as giant kelp; Amanita, Tsunomata,
Red algae such as Suginori, Usbanori, Asakusanori, Matsunori, Tosakamatsu, Funori, Ogonori, Kamensou, Igisu and Egonori; Chlorella, Aonori, Donariella,
Green algae such as Chlorococcus, Anaaosa, Kawanori, Marimo, Shiogusa, Kasanori, Fujuzumo, Tamajumo, Aegusa, Amidoro, etc .; cyanobacteria extracts such as Spirulina), juniper japonica extract, Sempukuka extract, grape extract, wheat extract, tomato extract Substance, asparagus extract, ibukitoranoo extract, Neubarra (Ageitsu) extract, eleuthero extract, pea extract, chamomile extract, causticus extract, orange extract, raspberry extract, kiwi extract, clara ( Kujin) extract, coffee extract, sesame oil, sesame oil, gokahi extract, rice extract, saishin extract, hawthorn extract, sunpens extract (pepper), peony extract, white lily extract, mulberry extract Liquid, Touki extract,
Beech extract, blackcurrant extract, hop extract,
Maikaika (Maikai, Hermanus) extract, Mokka (Bokeh) extract, Yukinoshita extract, Tea extract (Oolong tea, black tea, green tea, etc.), Soybean extract, Molasses extract, Rakan fruit extract, Reishi extract, microorganism Examples include fermentation metabolites and the like, or a mixture thereof. In the specific examples of the extract, the names in parentheses are plant aliases, crude drug names, and the like.

Anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin). Adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), aloe extract, acitaba extract, altea extract, arnica extract, sulfur and its derivatives, nettle extract , Chinese mackerel extract, Turmeric extract, Yellowfin extract, Hypericum extract, Chamomile extract, Comfrey extract, Watermelon (Kinginka) extract, Watercress extract, Salvia (Say) ) Extract, oleander extract, perilla extract, perilla extract, birch extract, elder extract, cattail extract, sucrose extract, eucalyptus extract, mugwort extract, astragalus extract Examples thereof include extracts, chondroitin sulfate and its derivatives, zinc oxide and the like, or a mixture thereof. In the specific examples of the extract, the names in parentheses are plant aliases, crude drug names, and the like.

The active oxygen scavenger is used for the purpose of suppressing the production of lipid peroxides, and includes superoxide dismutase, mannitol, L-histidine, quercetin, catechin and its derivatives, rutin and its derivatives, Botanpi extract, Yashajitsu extract. , Melissa extract, Rakan fruit extract, thiamine and its derivatives, riboflavin and its derivatives, pyridoxine and its derivatives, nicotinic acid and its derivatives, vitamin Bs, tocopherols and its derivatives, dibutylhydroxytoluene and butyl Examples thereof include hydroxyanisole and the like, or a mixture thereof.

Antioxidants include vitamin E and its derivatives (dl-α (β, γ) -tocopherol, acetic acid dl.
-Α-tocopherol, nicotinic acid-dl-α-tocopherol, linoleic acid-dl-α-tocopherol, tocopherols and derivatives thereof such as dl-α-tocopherol succinate, ubiquinones, etc., vitamin A and its derivatives (palmitic acid) Retinol, retinol such as retinol acetate and its derivatives, retinal such as dehydroretinal and derivatives thereof, carotenoid (carotene, lycopene, astaxanthin, etc.), vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate riboflavin) , Pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide,
Nicotinic acid such as benzyl nicotinate, choline, etc.),
Vitamin C and its derivatives (L-ascorbic acid phosphoric acid ester, L-ascorbic acid sulfuric acid ester, dipalmitic acid L-ascorbyl, tetraisopalmitic acid L-
Ascorbyl, etc.), vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystanal, etc.), rutin and its derivatives, thiotaurine, taurine, hydroquinone and its derivatives, histidine, catechin and its derivatives, glabridin, glabrene, liquiritin. , Isoliquiritin and licorice extract containing them, glutathione and derivatives thereof,
Gallic acid and its derivatives, cucumber extract, cabbage extract, gentian (gentian) extract, ginger extract, cholesterol and its derivatives, hawthorn extract, peony extract, superoxide dismutase, ginkgo biloba extract, Scutellaria baicalensis Extract, carrot extract, Maikaika (Makai, Hermanus) extract, Sunpens (Kawara Ketsumei) extract, Tormentilla extract, parsley extract, grape extract, button (Panpi) extract, mannitol, mokka (bokeh)
Extract, Melissa extract, Yashajitsu (Yasha) extract, Yukinoshita extract, Rosemary (mannen wax)
Extract, lettuce extract, Rakan fruit extract, tea extract (oolong tea, black tea, green tea, etc.), microbial fermentation metabolite, seaweed extract, ganoderma lucidum extract, eggshell membrane extract, placenta extract, etc., or their A mixture may be mentioned. In the specific examples of the extract, the names in parentheses are plant aliases, crude drug names, and the like.

As the cell activating agent, vitamin A and its derivatives (retinol palmitate, retinol acetate, etc., retinol and its derivatives, dehydroretinal, etc., retinal and its derivatives, etc.), carotenoids (carotene, lycopene, astaxanthin, etc.), vitamins B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinamide,
Nicotinic acid such as benzyl nicotinate, choline, etc.),
Vitamin C and its derivatives (L-ascorbic acid phosphoric acid ester, L-ascorbic acid sulfuric acid ester, dipalmitic acid L-ascorbyl, tetraisopalmitic acid L-
Ascorbyl etc.), ribonucleic acid and its salt, deoxyribonucleic acid and its salt, α- and γ-linolenic acid, xanthine and its derivatives (caffeine etc.), almond extract,
Asparagus extract, amino acids and their derivatives (serine, glutamic acid, theanine, hydroxyproline, pyrrolidone carboxylic acid, etc.), apricot (kyonin) extract, ginkgo extract, docosahexaenoic acid and its derivatives, eicosapentaenoic acid and its derivatives, Yellowfin (Otaku) extract, barley (Bakuga) extract, kiwi extract, cucumber extract, citric acid, succinic acid, shiitake extract, horsetail extract, assembly extract, soybean extract, jujube extract , Centella asiatica extract, Capsicum extract, Capsicum extract, Tomato extract, Garlic extract, Carrot extract, Hinokitiol, Bukyou extract, Grape seed oil, Beech extract, Peach extract, Eucalyptus extract, Lily extract Thing, lettuce extract, lemon extract, rosemary (Mannen wax) extract, animal-derived extract (mollusk extract such as squid, shell extract, shellfish extract, fish meat extract, chicken cob extract, silk protein and its degradation products, placenta extract, serum deproteinization extract Substance, royal jelly, lactoferrin or its decomposition product), microbial fermentation metabolites (derived from lactic acid bacteria, yeast, bifidobacteria, etc.), Reishi extract, etc., or a mixture thereof. In the specific examples of the extract, the names in parentheses are plant aliases, crude drug names, and the like.

Examples of moisturizers include proteins such as elastin and keratin or derivatives thereof, hydrolysates and salts thereof, amino acids such as glycine, serine, aspartic acid, glutamic acid, arginine and theanine and derivatives thereof, glucose and sucrose. And derivatives thereof, dextrin and derivatives thereof, saccharides such as honey, D-panthenol and derivatives thereof, urea, phospholipids, ceramide, laurel extract, ginseng extract, diorhea extract, psyllium extract, mallow extract, tachi Musk extract, Dokudami extract, Hamamelis extract, Bodaiju extract,
Examples thereof include horse chestnut extract, quince extract and the like, or a mixture thereof. A moisturizing water-soluble polymer can also be used as a moisturizing agent. Moisturizing water-soluble polymers include chondroitin sulfate, hyaluronic acid, mucin, dermatan sulfate, mucopolysaccharides selected from heparin and keratan sulfate and salts thereof, alginic acid and salts thereof, gum arabic, agar, pullulan, carrageenan, locust bean gum. ,
Xanthan gum, chitin, hydrolyzed chitin, gelatin,
Starch, collagen, cellulose, crystalline cellulose,
Methyl cellulose, hydroxypropyl cellulose, hydroxymethyl propyl cellulose, ethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, carboxymethyl cellulose and its salts, polyvinyl alcohol, polyvinyl pyrrolidone, carboxy vinyl polymer, alkyl modified carboxy vinyl polymer, acrylic acid methacrylic acid Examples thereof include alkyl copolymers. A polyhydric alcohol can also be used as a moisturizer. Polyhydric alcohols include glycerin, diglycerin, propylene glycol, dipropylene glycol-
And 1,3-butylene glycol, sorbitol, erythritol, maltitol, xylitol, xylose, trehalose, inositol, glucose, polyethylene glycol.

[0036]

The present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to the following examples.

(Example 1: Steam distillate of Oro Blanco fruit) 100 of Oro Blanco fruit divided into appropriate sizes
g is steam-distilled using a known steam distillation device,
The water-soluble component layer (aqueous layer portion) of the obtained distillate was collected and filtered to obtain about 1 kg of a steam distillate of Oro Blanco fruit.

(Example 2: Steam distillate of Orobranco fruit) To the steam distillate obtained in Example 1, 0.1% by mass of methyl paraoxybenzoate (hereinafter, simply referred to as "%") was added. , A steam distillate of Oro Blanco fruit was obtained.

(Example 3: Ethanol extract of Oro Blanco fruit) To 1 kg of Oro Blanco fruit was added 10 L of a mixed solvent of ethanol and water (volume ratio 1: 1), extraction was carried out at room temperature for 3 to 7 days, and the mixture was filtered. The resulting filtrate is 1 at 4 ° C
After cold storage for a week, the precipitated insoluble component was removed.
Then, it filtered using a 0.45 micrometer membrane filter and obtained the ethanol extract of the Oro blanco fruit.

(Example 4: 1,3-butylene glycol extract of Orobranco fruit) Instead of the mixed solvent of ethanol and water used in Example 3, a mixed solvent of 1,3-butylene glycol and water (volume ratio) was used. The same extraction was performed using 1: 1) to obtain a 1,3-butylene glycol extract of Oro Blanco fruit.

(Example 5: Water extract of Oro blanco fruit) Instead of the mixed solvent of ethanol and water used in Example 3, hot water (70 ° C.) was used for extraction for 3 to 5 hours, and the same procedure was performed. An aqueous extract of Oro Blanco fruit was obtained.

(Example 6: Lotion) Lotion was prepared by the composition shown in Table 1 and the following production method. The solution in which the components (1) to (5) are mixed and dissolved and the solution in which the components (10) to (13) are mixed and dissolved are mixed to make uniform, and further the components (6) to
(9) was added to obtain lotion.

Each of the resulting lotions 1 to 5 of the present invention and lotion 1 of the comparative product was subjected to the following sensory evaluations. The results are shown in Table 1. (Sensory evaluation test) Fifteen women aged 22 to 40 were used as a panel, and each lotion thus prepared was contained in an appropriate amount in cotton and applied to the skin. At this time, the odor and the feeling of use (freshness, moist feeling) of the product of the present invention relative to the comparative product were evaluated according to the following criteria. (Evaluation Criteria) <Odor> ◯: There was no raw material odor. Δ: There was almost no raw material odor. X: The same raw material odor as that of the comparative product was produced. <Feeling in use> ○: Good. Δ: Good. X: The feeling of use was the same as that of the comparative product.

[0044]

[Table 1]

As shown in the results of Table 1, the lotion of the present invention containing the steam distillate of Oro Blanco fruit and the extract of Oro Blanco fruit was compared with the lotion of Comparative product.
There is no raw material odor and the user can feel a good scent,
It was possible to obtain a better usability.

Examples of cosmetics (cosmetics for skin and cosmetics for hair), oral hygiene and bath agents containing steam distillates of Oroblanco fruits and extracts of Oroblanco fruits are shown below. The cosmetics (cosmetics and hair cosmetics), oral hygiene and bath preparations of the examples are all excellent in stability over time, have no raw material odor, and have an excellent feeling of use with the aroma of Oro Blanco fruit. Met.

(Example 7: Shampoo) The following components (1) to
The mixture obtained by mixing (4) with (5) and (6) was added to (7).
Was added to the solution dissolved in and thoroughly mixed to obtain a shampoo. (Prescription) (%) (1) Lauryl sulfate triethanolamine 5.0 (2) Polyoxyethylene lauryl ether sodium sulfate 12.0 (3) 1,3-butylene glycol 4.0 (4) Lauric acid diethanolamide 2 .0 (5) Disodium edetate 0.1 (6) Methyl paraoxybenzoate 0.1 (7) Steam distillate of Oro Blanco fruit * 1 Remaining amount * 1 Produced in Example 1

(Example 8: Rinse) The following components (1) to (5)
The mixed mixture was maintained at 70 ° C. This mixture
(6) was added to (8) and added to the mixture maintained at 70 ° C. to emulsify, and after cooling, (7) was added to obtain a rinse. (Prescription) (%) (1) Cetyltrimethylammonium chloride 1.5 (2) Cetanol 2.5 (3) Squalane 2.0 (4) Polyoxyethylene stearyl ether 1.0 (5) 1,3-butylene glycol 5.0 (6) Methyl paraoxybenzoate 0.1 (7) 1,3-Vetylene glycol extract of Oro Blanco fruit * 1 1.0 (8) Purified water Remaining amount * 1 Produced in Example 4

(Example 9: Mouthwash) A solution prepared by mixing and dissolving the following component (2) in the component (1) was used (3)-
(8) was added to the solution mixed and dissolved in (9) and mixed to obtain a mouthwash. (Prescription) (%) (1) Ethanol 10.0 (2) Polyoxyethylene hydrogenated castor oil 1.0 (3) Glycerin 15.0 (4) Sodium benzoate 0.3 (5) Sodium saccharin 0.02 (6) ) Aluminum lactate 0.01 (7) Ethanol extract of Oro Branco fruit * 1 5.5 (8) Scutellaria extract * 2 2.0 (9) Purified water Remainder * 1 What was produced in Example 3 * 2 Ichimaru Falcos Made

(Example 10: Lotion) The following components (4)-
The mixture obtained by adding (6) and (8) to (7) is mixed,
The following components (1) to (3), (9) and (10) are replaced by (1
To 1), the mixture was added and mixed to obtain a lotion. (Prescription) (%) (1) Glycerin 5.0 (2) L-histidine 0.2 (3) Propylene glycol 4.0 (4) Oleyl alcohol 0.1 (5) Polyoxyethylene (20) sorbitan monolaur Rate 1.5 (6) Polyoxyethylene (20) Lauryl ether 0.5 (7) Ethanol 7.0 (8) Methyl paraoxybenzoate 0.1 (9) Steam distillate of Oro Blanco fruit * 1 50.0 ( 10) Comfrey extract * 2 5.0 (11) Purified water Remaining amount * 1 What was produced in Example 2 * 2 Made by Ichimaru Falcos

(Example 11: Anti-aging cream) The following components (1) to (6) and (11) were mixed and maintained at 70 ° C. This mixture was added to (1) to (7), (8) and (13).
In addition to 4), the mixture was maintained at 70 ° C. and emulsified. After cooling, (9), (10) and (12) were added to obtain a cream. (Prescription) (%) (1) Squalane 20.0 (2) Beeswax 5.0 (3) Refined jojoba oil 5.0 (4) Glycerin monostearate 2.0 (5) Polyoxyethylene (20) sorbitan mono Stearate 2.0 (6) Sorbitan monostearate 2.0 (7) Glycerin 5.0 (8) 1,3-butylene glycol 10.0 (9) Steam distillate of Oro Blanco fruit * 1 20.0 (10) ) 1,3-Ventilenglycol extract of Orobranco fruit * 2 3.0 (11) Retinol palmitate * 3 0.005 (12) Yashajitsu extract * 4 0.2 (13) Methyl paraoxybenzoate 0.1 ( 14) Purified water Remainder * 1 Manufactured in Example 1 * 2 Manufactured in Example 4 * 3 Sigma * 4 Ichimaru Falcos

(Example 12: Whitening emulsion) The following components (1) to
(10) was mixed and maintained at 70 ° C. This mixture
(15) was added to (16) and added to the mixture maintained at 70 ° C. to emulsify, and after cooling, (11) to (14) and (17)
Was added to obtain an emulsion. (Prescription) (%) (1) Squalane 5.0 (2) Olive oil 5.0 (3) Jojoba oil 5.0 (4) Cetanol 1.5 (5) Glycerin monostearate 2.0 (6) Polyoxy Ethylene (20) cetyl ether 3.0 (7) Polyoxyethylene (20) sorbitan monooleate 2.0 (8) Acetic acid dl-α-tocopherol * 1 0.5 (9) 1,3-butylene glycol 15.0 (10) Glycerin 2.0 (11) Magnesium L-ascorbyl phosphate * 2 3.0 (12) Steam distillate of Oro Blanco fruit * 3 5.0 (13) Ethanol extract of Oro Blanco fruit * 4 3.0 (14) Orchid extract * 5 0.3 (15) Methyl paraoxybenzoate 0.15 (16) Purified water Remaining amount (17) Perfume proper amount * 1 Wako Pure Chemical Industries * 2 Wako Pure Chemical Those prepared in sex * 3 Example 2 * 4 Example 3 as produced in * 5 Ichimaru Pharcos Co.

Example 13: Cleansing Cream (W / O
Type)) The following components (1) to (6) were mixed and maintained at 70 ° C. To this mixture, add (10) to (11) and 70 ° C.
Added to the mixture maintained at, emulsified, and after cooling (7)
(9) was added to obtain a cleansing cream. (Prescription) (%) (1) Paraffin 10.0 (2) Beeswax 3.0 (3) Vaseline 15.0 (4) Liquid paraffin 41.0 (5) Sorbitan sesquioleate 4.2 (6) Polyexi Ethylene sorbitan (20) Monooleate 0.8 (7) Oro-Branco fruit 1,3-butylene glycol extract * 1 2.0 (8) Oro-Branco fruit water extract * 2 2.0 (9) Daffodil extract * 3 0.1 (10) Ethyl paraoxybenzoate 0.05 (11) Purified water Remainder * 1 Manufactured in Example 4 * 2 Manufactured in Example 5 * 3 Manufactured by Ichimaru Falcos

Example 14 Hair Cream The following component (1)
~ (7) were mixed and maintained at 70 ° C. This mixture
(10) was added to (11) and added to the mixture maintained at 70 ° C. to emulsify, and after cooling, (8) and (9) were added to obtain a hair cream. (Prescription) (%) (1) Liquid paraffin 30.0 (2) Stearic acid 5.0 (3) Cetanol 5.0 (4) Sorbitan monooleate 3.0 (5) Polyoxyethylene sorbitan monooleate 3 0.0 (6) Isopropylmethylphenol 0.1 (7) Methyl paraoxybenzoate 0.2 (8) Steam distillate of Oro Blanco fruit * 1 10.0 (9) Water extract of Oro Blanco fruit * 2 0.5 ( 10) Glycerin 5.0 (11) Purified water Remainder * 1 Manufactured in Example 1 * 2 Manufactured in Example 5

(Example 15: Hair tonic) The following component (1)
(8) were mixed and dissolved. This solution was added to (9) and mixed to obtain a hair tonic. (Prescription) (%) (1) L-menthol 0.2 (2) Ethanol 32.5 (3) Polyoxyethylene hydrogenated castor oil 0.5 (4) Nicotinic acid amide * 1 0.1 (5) Propylene glycol 5 0.0 (6) Diphenhydramine hydrochloride 0.3 (7) 1,3-Vetylene glycol extract of Oro Blanco fruit * 2 7.0 (8) Methyl paraoxybenzoate 0.2 (9) Purified water Remainder * 1 Sigma Manufactured * 2 Manufactured in Example 4

(Example 16: Cream foundation (W
/ O type)) The following components (1) to (6) were mixed and maintained at 70 ° C. This mixture was added to (7) to (10) and (1
4) was added to the kneaded mixture and mixed. This mixture was mixed with (15) to (17) and added to the mixture maintained at 70 ° C to emulsify the mixture. After cooling, (11) to (13) were added to obtain a cream foundation. (Prescription) (%) (1) Sorbitan sesquioleate 3.0 (2) Self-emulsifying glyceryl monostearate 2.0 (3) Aluminum stearate 0.5 (4) Ceresin wax 5.0 (5) Squalane 10.0 (6) Vaseline 5.0 (7) Liquid paraffin 15.0 (8) Shea butter * 1 2.0 (9) Titanium oxide 8.0 (10) Talc 4.0 (11) Oro Blanco fruit steam Distillate * 2 2.0 (12) Water extract of Oro Blanco fruit * 3 0.2 (13) Kiwi extract * 4 1.0 (14) Coloring pigment Appropriate amount (15) Methyl paraoxybenzoate 0.1 (16 ) Propylene glycol 5.0 (17) Purified water Remainder * 1 Made by Ichimaru Falcos * 2 Made by Example 2 * 3 Made by Example 5 * 4 Made by Ichimaru Falcos

(Example 17: Granular bath agent) The following component (1)
~ (5) were mixed and stirred to obtain a bath agent. (Prescription) (%) (1) Sodium hydrogencarbonate 53.0 (2) 5% by mass of ethanol extract of the Oroblanco fruit of Example 3 concentrated 5 times and dried to dry anhydrous sodium sulfate 40.0 (3) Boron Sand 2.0 (4) Dye Appropriate amount (5) Ogon Extract * 1 5.0 * 1 Made by Ichimaru Falcos

[0058]

The external preparation of the present invention containing a component derived from Oro Blanco fruit (preferably steam distillate, etc.) has a good fragrance, masks the dough odor (raw material odor), and is excellent in usability. There is. Further, the flavoring agent of the present invention has a high fragrance, is stable when compounded in an external preparation such as an external medicine or a cosmetic, and can continuously emit the fragrance.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/08 A61K 7/08 7/26 7/26 7/50 7/50 35/78 35/78 K A61P 17/16 A61P 17/16 (72) Inventor Taku Hoshino 48-18 Sakaemachi, Kita-ku, Tokyo Kose Co., Ltd. Research Division (72) Inventor Yukiko Niimoto 48-18 Sakaemachi, Kita-ku, Tokyo Kose Research Headquarters (72) Inventor Michimasa Hori No. 1 318, Asagi, Masashi-cho, Motosu-gun, Gifu Ichimaru Falcos Co., Ltd. (72) Maki Ohno No. 318 Asagi, Masashi-cho, Motosu-gun, Gifu Ichimaru Falcos Co., Ltd. (72) Inventor Takayuki Anzai No. 318, Asagi, Masaki-cho, Motosu-gun, Gifu Ichimaru Falcos Co., Ltd. F-term (reference) 4C083 AA111 AA112 AB152 AB242 AB312 AB442 AC012 AC022 AC072 AC102 AC122 AC182 AC302 AC432 AC442 AC482 AC532 AC552 AC582 AC642 AC692 AC782 AC852 AC862 AD532 AD642 AD662 CC01 CC02 CC04 CC05 CC25 CC31 CC33 CC38 CC39 CC41 DD23 DD31 EE01 EE06 EE12 EE16 EE21 EE31 EE41 4C088 AB62 AC04 BA09 BA10 CA05 MA22 MA28 MA16 MA02 MA16 MA01 NA ZA89

Claims (4)

[Claims] 1. An external preparation containing an ingredient derived from Oro Blanco fruit. 2. The external preparation according to claim 1, which contains a steam distillate of Oro Blanco fruit as a component derived from Oro Blanco fruit. 3. The ingredient derived from Oro Blanco fruit,
The external preparation according to claim 1, which comprises an extract of Oro Blanco fruit with water and / or a water-soluble solvent. 4. A flavoring agent comprising an ingredient derived from Oro Blanco fruit.