JP2003063925A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation having excellent whitening and/or beautifying effects and storage stability. SOLUTION: This skin care preparation includes a component derived from Phyllanthus emblica L., preferably a solvent extract, vapor distillate, fruit juice, or pressed seed oil thereof.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to
Anthus emblica L.)-related external preparations for skin containing components. More specifically, it contains an ammalok-derived component to prevent and improve pigmentation such as dullness of skin, spots, freckles, senile pigment spots and liver spots, and improve the transparency of the skin to whiten and / or beautiful skin. The present invention relates to a skin external preparation which exhibits excellent effects.

[0002]

2. Description of the Related Art Conventionally, skin external preparations such as emulsions, creams, lotions, beauty essences, packs, detergents, dispersions, ointments, liquids, aerosols, patches, poultices, liniments, etc. Various medicinal components are added for the purpose of imparting desired medicinal effects. For example, ascorbic acid, placenta extract, glutathione, and whitening agents such as hydroquinone are added to external preparations for skin in order to prevent or improve skin darkening caused by sunburn etc., spots caused by pigmentation, freckles, etc. .

[0003] However, these whitening agents may not be able to achieve the desired medicinal effect due to insufficient whitening effect or deterioration in the formulation, and improvement thereof has been desired.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide an external preparation for skin which has a good whitening and / or skin beautifying effect and has good storage stability.

[0005]

Means for Solving the Problems The inventors of the present invention have made extensive studies as to a material that can be used as a medicinal component of an external preparation for skin, and as a result, have found that a component derived from ammalok has a high melanin production inhibitory action. In addition, the ingredient derived from Ammalok can be blended into a skin external preparation as a whitening and / or skin beautifying ingredient, and when combined with other medicinal ingredients, an excellent whitening effect and a comprehensive skin beautifying effect can be obtained as a skin external preparation. Heading out, the present invention has been completed.

That is, the present invention is based on the Ammarok (Phyllan
Thus, an external skin preparation containing a component derived from emblica L.) is provided. As a preferred embodiment of the external preparation for skin of the present invention, the component derived from ammalok is an extract of ammaloc,
There is provided the above-mentioned external preparation for skin, which is any one of a solvent extract, a steam distillate, fruit juice, fruit water separated in a fruit juice concentration step, and pressed oil of seeds.

As a preferred embodiment of the external preparation for skin of the present invention, there is provided the external preparation for skin as described above, which contains the component derived from Ammalok as a whitening and / or beautiful skin component.
Further, as a further preferred embodiment of the skin external preparation of the present invention, a skin external preparation containing at least one selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activating agent and an anti-UV agent together with the component derived from Ammalok. Provided. From another point of view, the present invention provides a skin external preparation containing an ammalok-derived component as a melanin production inhibitor.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention is an external preparation for skin, which contains an ingredient derived from Ammalok. Ammarok is the scientific name of Philanthus emblica (Phyllanthus e
mblica L.) is a plant belonging to the Euphorbiaceae family,
In the life science "Ayurveda" of Indian tradition, it is known as "Amla". The above-mentioned anmarok is a plant widely distributed in Asian countries such as India, Indochina, Taiwan, and Fujian / South China / Southwest China in China, but its kind and production area are not particularly limited.

The component derived from Ammalok used in the present invention may be a component derived from any part of the root, stem, stem, bark, shoots, leaves, flowers, fruits, seeds, etc. of Ammalok. In the present specification, the term "ammaloc-derived component" should be interpreted in the broadest sense including an ammalok extract, etc., and is a concept that includes all one-component substances derived from ammaloc or a mixture of a plurality of component substances derived from ammaloc. Used as. Further, the external preparation for skin of the present invention,
The components derived from ammalok obtained from two or more parts may be mixed and used, or two or more components derived from ammalok prepared from different parts from two or more parts may be mixed and used. In general, each part of the amarok can be subjected to a pretreatment such as drying, shredding, squeezing or fermentation, if desired, and then the amarok-derived component can be collected by various operations such as extraction. However, the method for preparing the component derived from Ammalok is not limited to the above example.

A preferred embodiment of the external preparation for skin of the present invention is an external preparation for skin in which the component derived from Ammalok is an extract of Ammalok. The extract of Ammalok can be extracted from one or more locations such as roots, stems, stems, barks, buds, leaves, flowers, fruits and seeds of Ammalok. In general, an extract obtained by subjecting these portions to an appropriate treatment such as drying, shredding, squeezing, or fermentation, and then extracting with a solvent at low temperature or under heating is preferable. The solvent extraction method is not particularly limited, for example, roots, stems, stems, bark, buds, leaves, flowers,
Examples thereof include a method of immersing any one of fruits, seeds and the like, or two or more kinds of portions in a solvent at low temperature or room temperature to heating for a predetermined time. As the extraction solvent, water, lower monohydric alcohol (methyl alcohol, ethyl alcohol, 1-
Propanol, 2-propanol, 1-butanol, 2
-Butanol, etc.), liquid polyhydric alcohol (glycerin,
Propylene glycol, 1,3-butylene glycol, etc.), lower alkyl esters (ethyl acetate, etc.), hydrocarbons (benzene, hexane, pentane, etc.), ketones (acetone, methyl ethyl ketone, etc.), ethers (diethyl ether, tetrahydrofuran, di) Propyl ether, etc.), acetonitrile, etc., among which one or more can be used.

An example of a method for preparing an extract of Ammalok preferably used in the present invention is shown below. The portion of Ammalok to be extracted is immersed in ethyl alcohol or 1,3-butylene glycol containing water at a concentration of 0 to 100% by volume, room temperature or warmed, and extraction is performed for 1 to 5 days.
After that, the extract is filtered, and the obtained filtrate is left to stand for another week for aging to be aged, and then filtered again to obtain the target extract.

Another preferred embodiment of the external preparation for skin of the present invention is an external preparation for skin in which the component derived from Ammarok is a steam distillate. Here, the steam distillate refers to a distillate obtained by steam-distilling any one of the roots, stems, bark, buds, leaves, flowers, fruits, seeds, etc. of Ammalok, or two or more parts. . The distillate usually contains an essential oil component layer and a water-soluble component layer, and either one or both may be used, but the water-soluble component layer is preferably used as a steam distillate. Steam distillation can be performed according to a conventional method.

Another preferred embodiment of the external preparation for skin of the present invention is an external preparation for skin in which the component derived from Ammalok is juice of Ammalok. The juice of Ammaroku is
It can be obtained by pressing the fruits of Ammarok. Concentrated fruit juice obtained by evaporating water from the fruit juice obtained by pressing may be used, or concentrated reduced fruit juice obtained by reducing with water or the like after concentration may be used. The concentration can be carried out by any of heat concentration, reverse osmosis membrane concentration, freeze concentration, or a combination thereof, but the concentration method is not limited to the above example.

Another preferred embodiment of the external preparation for skin of the present invention is an external preparation for skin in which the component derived from Ammalok is fruit water of Ammalok. Ammalok fruit water is water separated from the concentrated juice in the process of concentrating the juice of Ammalok, and is water containing a minute amount of components (for example, minerals, glucose, fructose, etc.) contained in the fruits of Ammalok. For example, in the case of concentrating Ammarok fruit juice by heating, distilled water generated in the heating and concentrating step; in the case of reverse osmosis membrane concentration, osmotic water separated from the concentrated fruit juice; The water obtained by melting the resulting ice can be used as fruit water.

As another preferred embodiment of the external preparation for skin of the present invention, an external preparation for skin in which the component derived from Ammalok is pressed oil of seed of Ammalok is mentioned. The pressed oil of Ammaroku seeds is an oil component obtained by pressing the seeds. The pressed oil of the seed can be prepared according to various conventional methods. If desired, the pressed oil obtained by pressing the seeds of Ammarok can be subjected to phosphoric acid treatment for removing impurities, alkali neutralization treatment, water washing treatment, decolorization treatment, dehydration treatment and the like.

In the present invention, after the Ammalok-derived component is collected by extraction or the like, it is left as it is for an appropriate period,
It can also be used after aging. Further, if necessary, it can be used after being subjected to a purification treatment such as deodorization and decolorization within a range that does not affect the effect. Examples of the purification method include filtration or purification by adsorption using an ion exchange resin or the like. The purification can be repeated, and when it is repeated, two or more methods can be combined. Further, it is also possible to use only a fraction having a high activity by using a separating means such as gel filtration, liquid chromatography, distillation or the like.

In the present invention, the components derived from Ammalok may be used alone or in combination of two or more kinds,
It may be contained in the external preparation for skin in any form such as liquid, paste or gel. Origin components collected in liquid form,
It may be incorporated into an external preparation for skin after being dried and solidified or dried by spray drying or the like to be a powder.

The content of the component derived from ammalok in the external preparation for skin of the present invention is not particularly limited, but for example, 1 × 10 ^{−5 to} 5% by mass as a dry solid content (hereinafter, “%” means “%” unless otherwise specified). Mass% is preferable), 1 × 1
^{0-4 to} 2% is more preferable. When the content is within the above range, the component derived from ammalok can be more stably blended, and excellent whitening and / or skin beautifying effect can be exhibited. When an extract is used as the component derived from Ammalok, it is preferable that the content of the dry solid content of the solute is within the above range. Further, when the water-soluble component layer of fruit water or steam distillate is used as the component derived from Ammalok, the preferable content is not particularly limited, and it can be blended in a skin external preparation as an alternative to purified water, for example. In this case, it is preferable to select a blending amount sufficient to exert a whitening and / or skin beautifying effect, but a person skilled in the art can apply the skin external preparation of the present invention according to the method specifically shown in the Examples of the present specification. The whitening and / or skin beautifying effect of the agent can be confirmed.

In the present specification, the term "beautiful skin" is construed in the broadest sense including, for example, suppression of pigmentation, dull skin, darkening of the skin due to sunburn, prevention and improvement of spots and freckles. It is necessary to understand that "whitening" is included in the scope.

The external preparation for skin of the present invention uses the ingredient derived from Ammalok as a whitening and / or skin beautifying ingredient according to a conventional method,
It can be prepared by blending with various forms of bases and formulating. Furthermore, by blending the ingredient derived from ammalok in combination with one or more other medicinal ingredients, a skin external preparation having more excellent whitening and / or skin beautifying effect can be prepared.

In the present invention, as other medicinal components (hereinafter sometimes referred to as "component (B)") which can be combined with the above-mentioned components derived from ammalok (hereinafter sometimes referred to as "component (A)"), Whitening agents, antioxidants, anti-inflammatory agents, cell activators and anti-UV agents. Specific examples of each medicinal component will be given below. In the following specific examples, the “derivative” includes a salt that can be formed. In addition, compounds having two or more drug efficacy are duplicated as specific examples of each drug component.

(Whitening agents) As whitening agents, vitamin C and its derivatives (L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate and L-ascorbyl tetraisopalmitate, L-ascorbic acid phosphate, L -Ascorbic acid sulfate, etc.), placenta extract, glabridin, glabrene, liquiritin, isoliquiritin and licorice extract containing these, Yokuinin (Huttogi) extract, Scutellaria baicalensis (Ougon) extract, seaweed extract (konbu, macombu, Brown algae such as wakame, hijiki, hibamata, shimeji, torocombu, kajime, tsurame, chigaiso, hondarawa, giant kelp, etc .; agar beetle, giant sardine, hornwort, horse mackerel, usbanori, asakusanori, matsunori,
Red algae such as Tosakamatsu, Funori, Ogonori, Kamensou, Igisu, Egonori, etc .; Chlorella, Aonori, Donariera, Chlorococcus, Anaaosa, Kawanori, Marimo, Shiogusa, Casanori, Fujujumo, Tamajuso, Astragalus, Algae etc. , Etc.), juniper extract, senpukuka extract,
Grape extract, wheat extract, tomato extract, carotenoid (carotene, lycopene, astaxanthin, etc.), agarose, oligosaccharide, neo-agarobiose,
Hydroquinone and its derivatives, cysteine and its derivatives, asparagus extract, acerola extract, ibukitrano extract, Neubara (Ageitsu) extract, eleuthero extract, pea extract, chamomile extract, cabbage extract, orange extract Thing, raspberry extract,
Kiwi extract, Clara (kujin) extract, Coffee extract, Sesame oil, Perilla oil, Gokahi extract, Rice extract, Saishin extract, Hawthorn extract, Sunpenz (Kawara-ketsumei) extract, Peony extract, Shirayuri extract ,
Mulberry (Souhakuhi) extract, Touki extract, Beech extract, Blackcurrant extract, Boricaria extract, Hop extract, Maikai (Maikai, Hermanus) extract,
Mokka (bokeh) extract, Yukinoshita extract, tea extract (oolong tea, black tea, green tea, etc.), Reishi extract, microbial fermentation metabolites, soybean extract, molasses extract, Rakan fruit extract, etc., or a mixture thereof Is mentioned. In the specific examples of the extract, the names in parentheses are plant aliases, crude drug names, and the like.

Of these whitening agents, especially preferred are vitamin C and its derivatives, placenta extract,
Examples include licorice extract, adlay (Yokuinin) extract, wheat extract, juniper extract, seaweed extract, and tea extract.

(Antioxidant) Antioxidants include vitamin E and its derivatives (dl-α (β, γ) -tocopherol, dl-α-tocopherol acetate, nicotinic acid-d).
1-α-tocopherol, linoleic acid-dl-α-tocopherol, succinate dl-α-tocopherol and other tocopherols and their derivatives, ubiquinones, etc., vitamin A and its derivatives (retinol and retinol palmitate, retinol acetate, etc.) Derivatives; derivatives such as retinal and dehydroretinal, etc.), carotenoids (carotene, lycopene, astaxanthin, etc.), vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinamide, nicotinic acid such as benzyl nicotinate,
Choline, etc., vitamin C and its derivatives (dipalmitate L-ascorbyl and tetraisopalmitate L-
L-ascorbic acid alkyl ester such as ascorbyl, L-ascorbic acid phosphoric acid ester, L-ascorbic acid sulfuric acid ester, etc.), vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystannal, etc.), rutin and its Derivative,
Thiotaurine, taurine, hydroquinone and its derivatives, histidine, catechin and its derivatives, glabridin, glabrene, liquiritin, isoliquiritin and licorice extract containing them, glutathione and its derivatives, gallic acid and its derivatives, cucumber extract, causticus extract , Gentian (gentian) extract, ginger extract, cholesterol and its derivatives, hawthorn extract, peony extract,
Superoxide dismutase, ginkgo extract,
Scutellaria baicalensis (carrot) extract, carrot extract, Maikai (Makai, Hermanus) extract, Sunpens (Kawara-Ketsumei) extract, Tormentilla extract, parsley extract, grape extract, button (Panpi) extract, mannitol, mocca ( Bokeh) extract, Melissa extract, Yashajitsu (Yasha) extract, Yukinoshita extract, Rosemary (mannen wax) extract, Lettuce extract, Tea extract (Oolong tea, black tea, green tea, etc.), Microbial fermentation metabolite, Seaweed Examples thereof include extracts, Reishi extract, eggshell membrane extract, placenta extract, Rakan fruit extract and the like, or a mixture thereof. In the specific example of the extract, parentheses are aliases of plants,
Indicates the name of crude drug.

Of these antioxidants, particularly preferred are vitamin E and its derivatives, and vitamin C.
And its derivatives, rutin and its derivatives, yashajitsu extract, yukinoshita extract, mite squid extract, superoxide dismutase, ginkgo extract, glutathione, histidine, mannitol, carotenoid.

(Anti-inflammatory agent) Examples of anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine diacid). Octanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), aloe extract, ashitaba extract, altea extract, arnica extract, sulfur and its Derivatives, nettle extract, Chinese mackerel extract, turmeric extract, yellowfin (Otter)
Extract, Hypericum extract, Chamomile extract, Comfrey extract, Honeysuckle extract, Watercress extract, Salvia extract, Salvia extract, Sikon extract , Perilla extract, birch extract, elderberry extract,
Examples thereof include a cattail (Phoutaceae) extract, a mukurodi extract, a eucalyptus extract, a mugwort extract, an extract of Chinese radix, chondroitin sulfate and its derivatives, zinc oxide and the like, or a mixture thereof. In addition, in the specific example of the extract,
The names in parentheses are the plant aliases, crude drug names, etc.

Among these anti-inflammatory agents, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamins B and their derivatives are particularly preferable.

(Cell activating agent) Cell activating agents include vitamin A and its derivatives (retinol, retinol palmitate, retinol acetate, etc .; retinal, dehydroretinal, etc.), carotenoids (carotene, lycopene, astaxanthin, etc.). ), Vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotine such as benzyl nicotinate) Acids, cholines, etc.), vitamin C and its derivatives (L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate and L-ascorbyl tetraisopalmitate,
L-ascorbic acid phosphate, L-ascorbic acid sulfate, etc.), ribonucleic acid and its salt, deoxyribonucleic acid and its salt, α- and γ-linolenic acid, xanthine and its derivatives (caffeine, etc.), almond extract , Asparagus extract, amino acid and its derivatives (serine, glutamic acid, theanine, hydroxyproline, pyrrolidone carboxylic acid, etc.), apricot (kyounin) extract, ginkgo extract, docosahexaenoic acid and its derivatives, eicosapentaenoic acid and its derivatives, Yellowfin (Otaku) extract, barley (Bakuga) extract, kiwi extract, cucumber extract, citric acid, succinic acid, shiitake extract, horsetail extract, assembly extract, soybean extract, jujube extract , Centella asiatica extract, Capsicum extract Gem, quince extract,
Tomato extract, garlic extract, carrot extract, hinokitiol, butterbur extract, grape seed oil, beech extract, peach extract, eucalyptus extract, lily extract, lettuce extract, lemon extract, rosemary (mannen wax) ) Extract, animal-derived extract (mollusk extract such as squid, shellfish extract, shellfish extract, fish meat extract, poultry extract, silk protein and its degradation products, placenta extract,
Examples thereof include serum deproteinized extract, royal jelly, lactoferrin or its degradation product), microbial fermentation metabolites (derived from lactic acid bacteria, bifidobacteria, etc.), Reishi extract, and the like, or a mixture thereof. In addition, in the specific example of the extract,
The names in parentheses are the plant aliases, crude drug names, etc.

Of these cell activating agents, particularly preferred are vitamin A and its derivatives, vitamin C and its derivatives, vitamin B and their derivatives, citric acid, malic acid, pyrrolidonecarboxylic acid, chicken cob extract, Examples include microbial-derived extracts such as serum deproteinized extract, yeast extract, lactic acid bacterium extract, bifidobacteria extract, and Reishi extract, or extracts selected from fermentation metabolites.

(Ultraviolet protection agent) As an ultraviolet protection agent,
2-Ethylhexyl paramethoxycinnamate, 4-te
rt-Butyl-4'-methoxydibenzoylmethane, oxybenzone and its derivatives (2-hydroxy-4-
Methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-
4-methoxybenzophenone-5-sulfonate, etc.), titanium oxide, zinc oxide, etc., or a mixture thereof. Further, if the powder is fine particles, a higher effect is exhibited.

Of these UV inhibitors, particularly preferable are 2-ethylhexyl paramethoxycinnamate, titanium oxide, fine particle titanium oxide and zinc oxide.

The compounding amount of the above-mentioned component (B) in the external preparation for skin of the present invention varies depending on the kind of the component, but generally the following range is preferable. When the above components (A) and (B) are combined within this range,
The desired whitening and / or skin beautifying effect of the component (A) can be obtained, and the desired medicinal effect of each medicinal component (B) can be obtained without affecting the stability of the preparation and the component (A) in the preparation over time. Can be demonstrated. That is, when the skin external preparation of the present invention contains a whitening agent, the compounding amount thereof is preferably 1 × 10 ⁻⁵ to 10%, and 1 × 10 ^{−4 to} 5%.
Is more preferable. When using the extract as it is,
The dry solid content is preferably in the above range. When the blending amount is within the above range, a more excellent whitening and / or skin beautifying effect can be exhibited, and a skin external preparation having a good feeling in use can be obtained.

When the external preparation for skin of the present invention contains an antioxidant, the content of the antioxidant is 1 × 10 ^{-5 to} 5%,
Is preferable, and 1 × 10 ^{−4 to} 3% is more preferable. When the extract is used as an extract as it is, it is preferable that the blending amount as the dry solid content is within the above range. When the blending amount is within the above range, a skin external preparation exhibiting a more excellent antioxidant effect and exhibiting an excellent whitening and / or skin beautifying effect can be obtained.

When the external preparation for skin of the present invention contains an anti-inflammatory agent, the compounding amount thereof is preferably 1 × 10 ^{-5 to} 5%,
It is more preferably 1 × 10 ^{−4 to} 3%. When the extract is used as an extract as it is, it is preferable that the blending amount as the dry solid content is within the above range. When the blending amount is in the above range, an external preparation for skin which exhibits an excellent anti-inflammatory effect and also has an excellent whitening and / or skin beautifying effect can be obtained.

The external preparation for skin of the present invention contains a cell activator.
If it is added, the blending amount is 1 × 10 ^-Five~ 5% is preferred
1 x 10^-Four3% is more preferable. Extract the extract
When used as it is, the blending amount as dry solid content is within the above range.
It is preferably surrounded. When the blending amount is within the above range, excellent
The effect of improving the roughened skin is exhibited and excellent whitening and
And / or an external skin preparation having a beautiful skin effect can be obtained.

When the external preparation for skin of the present invention contains an ultraviolet protective agent, the compounding amount thereof is preferably 1 × 10 ^{−3 to} 20%, more preferably 1 × 10 ⁻² to 10%. When the blending amount is in the above range, a more excellent ultraviolet ray prevention effect is exhibited,
In addition, a skin external preparation that exhibits an excellent whitening and / or skin beautifying effect can be obtained.

These whitening agents, antioxidants, anti-inflammatory agents, cell activators and UV inhibitors can be used alone or in combination of two or more.

The external preparation for the skin containing the component (B) in addition to the above-mentioned component (A) is known as a conventional external preparation for the skin in which the essential components (A) and (B) are contained according to a conventional method. It can be prepared by blending with various forms of bases.

The form of the external preparation for skin of the present invention is not particularly limited, and examples thereof include emulsions, creams, lotions, beauty essences, packs, detergents, makeup cosmetics, dispersions, ointments, solutions, aerosols, It may be a cosmetic in any form such as a patch, a poultice, or a liniment, or an external medicine.

In addition to the above-mentioned essential components, the external preparation for skin of the present invention is usually a formulation such as cosmetics, quasi-drugs, and external medicines, as long as it does not impair the effects of the present invention. Components used for, for example, water (purified water, hot spring water, deep sea water, steam distilled water of plants, etc.), oil agent, surfactant, metal soap, gelling agent, powder, alcohols, water-soluble One or more kinds of polymers, antibacterial agents, blood circulation promoters, active oxygen removers, moisturizers, pH adjusters, fragrances and the like can be added. Specific examples are given below, but the substances that can be incorporated into the external preparation for skin of the present invention are not limited to the above examples or the following specific examples. In the following specific examples, the “derivative” includes a salt that can be formed.

As the oil agent, a natural oil or a synthetic oil may be used as long as it is a constituent of the base or an agent which improves usability and usability and is used in ordinary cosmetics. Alternatively, regardless of properties such as solid, semi-solid or liquid, hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorine oils, etc.,
Or a mixture thereof can be used. For example, hydrocarbons such as squalane and vaseline, castor oil,
Examples thereof include oils and fats derived from plants and animals such as mink oil, waxes such as beeswax, carnauba wax, candelilla wax, and gay wax.

The surfactant is used for emulsification and solubilization of oils and the like, and anionic, cationic, nonionic or amphoteric surfactants or a combination thereof can be used.

As the metal soap, metal salts other than alkali salts such as fatty acids can be used.
Examples include aluminum stearate, magnesium stearate, zinc laurate, and the like, or a mixture thereof.

The gelling agent is used for stabilizing the system and improving the usability and the feeling of use, and includes amino acid derivatives such as N-lauroyl-L-glutamic acid, dextrin fatty acid esters such as dextrin palmitate, and sucrose. Examples thereof include fatty acid esters, organically modified clay minerals and the like, or a mixture thereof.

The powder is mainly used for various purposes such as coloring in makeup cosmetics, hiding the skin, or improving the feeling of use, and if it is used in ordinary cosmetics, its shape (spherical shape, needle shape) is used. Shape, plate shape, etc.), particle size (fume, fine particles, pigment grade, etc.) and particle structure (porous, non-porous, etc.), any of them can be used.
For example, as the inorganic powder, barium sulfate, calcium carbonate, talc, mica, synthetic mica, mica, kaolin, sericite, silicic acid, silicic acid anhydride, magnesium aluminum silicate, ceramic powder, boron nitride, or the like, or those Examples of the organic powder include polyester powder, polyethylene powder, polystyrene powder, nylon powder, lauroyl lysine, and the like, or a mixture thereof.Colored pigments include iron oxide, carbon black, chromium oxide, and navy blue. , Inorganic pigments such as ultramarine blue, tar-based pigments laked,
Examples include laked natural dyes, or a mixture thereof, and pearl pigments include titanium oxide-coated mica,
Titanium oxide coated mica, bismuth oxychloride, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, fish scale foil, titanium oxide coated colored mica, etc., other tar pigments,
Examples include natural pigments such as carminic acid and the like, or a mixture thereof. You may combine these powders and may perform surface treatment with an oil agent, silicone, or a fluorine compound.

As alcohols, lower alcohols such as ethanol and isopropanol, glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, etc., or Mention may be made of mixtures thereof.

The water-soluble polymer is used for stabilizing the system, improving the usability and the feeling of use, and also for obtaining the moisturizing effect. Specific examples of water-soluble polymers include carrageenan, pectin, agar, plant-based polymers such as locust bean gum, microbial-based polymers such as xanthan gum, animal-based polymers such as casein and gelatin, and starch-based polymers such as starch. , Methyl cellulose, ethyl cellulose,
Cellulosic polymers such as carboxymethyl cellulose, hydroxypropyl cellulose, nitrocellulose, alginic acid polymers such as sodium alginate, vinyl polymers such as carboxyvinyl polymer, polyoxyethylene polymers, polyoxyethylene polyoxypropylene copolymers. Examples include systemic polymers, acrylic polymers such as sodium polyacrylate, and the like, or a mixture thereof. In addition, a film forming agent such as polyvinyl alcohol or polyvinylpyrrolidone is also included in this.

The antibacterial agent is used for the purpose of preventing and improving acne and the like, and includes benzoic acid, sodium benzoate, paraoxybenzoic acid ester, parachlorometacresol, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol, or the like. A mixture of By blending these, pigmentation due to inflammation of bacterial skin such as acne can be suppressed, and further excellent whitening and / or skin beautifying effect can be exhibited.

The active oxygen scavenger is used for the purpose of suppressing the production of lipid peroxide by ultraviolet rays, and includes superoxide dismutase, mannitol, quercetin,
Catechin and its derivatives, thiamines (thiamine hydrochloride, thiamine sulfate), riboflavins (riboflavin, riboflavin acetate, etc.), pyridoxines (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), nicotinic acids (nicotinic acid amide, nicotinic acid) Vitamin Bs such as benzyl and the like; dibutylhydroxytoluene and butylhydroxyanisole and the like, or a mixture thereof. By blending these active oxygen removing agents, dullness can be suppressed and a more excellent whitening and / or skin beautifying effect can be exhibited.

Examples of moisturizers include proteins such as glycerin, 1,3-butylene glycol, collagen, elastin, and keratin or derivatives thereof, hydrolysates and salts thereof, mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, and derivatives thereof. , Histidine, serine, glycine, theanine, aspartic acid, arginine and other amino acids and their derivatives, sorbitol, erythritol, trehalose, inositol, glucose, xylitol, sucrose and its derivatives, dextrin and its derivatives, honey and other sugars, D- Panthenol and its derivatives, glycolipids, ceramides, licorice extract, almond extract, acitaba extract, avocado extract, altea extract, arnica extract, hot spring water, aloe extract, mung bean mallow Ginseng, Scutellaria baicalensis (Ouchon) extract, Coptis chinensis extract, Hypericum perforatum extract, Odorikosou extract, Ononis extract, Chamomile extract, Oat grass extract, glabridin, grabrene, liquiritin, isoliquiritin and licorice extract containing these, Rubus extract, Honeysuckle extract, Quinceseed extract, Clara extract, Gardenia extract, Kumazasa extract, Grapefruit extract, Watercress extract, Gentiana extract, Gentian ginger extract, Burdock extract , Sesame extract, Wheat extract, Comfrey extract, Cycin extract, Cactus extract, Sophoraceae extract, Salvia (Sage) extract, Hawthorn extract, Dioh extract, Perilla extract, Spirea extract Thing, peony extract , Ginger extract, ginger extract, white birch extract, peppermint (peppermint) extract, mallow (Pleurotus cornucopiae) extract, psyllium extract, mulberry (sawakuhi) extract, pearl oyster (thyme) extract, camellia Extract, Touki extract, Astragalus extract,
Corn extract, dokudami extract, tormentilla extract, parsley extract, mint extract, adlay extract,
Hamamelis extract, rose extract, cypress extract, sunflower extract, pyrrolidone carboxylic acid and its salts, coltsfoot extract, butchers bloom extract, grape extract, prune extract, loofah extract, vomitage extract, button ( Botanpi extract, hop extract, jojoba oil, macadamia nut oil, olive oil, apricot kernel oil, persic oil, safflower oil, sunflower oil, avocado oil, medhome oil, camellia oil, almond oil, perilla oil, sesame oil, borage ( Borage oil, cacao butter, shea butter, pine extract, quince extract, horse chestnut extract, mukuroji extract, mucin, purple (shikon) extract, meadow home oil, melissa extract, cornflower extract, yukinoshita extract , Lily extract, lime extract, lavender extract, apple extract Gentian extract, phospholipids derived from soybeans and eggs, lotus root extract, Chinese cabbage extract, tea extract (oolong tea, green tea, black tea, etc.), urea, luhan fruit extract, seaweed extract, etc., or a mixture thereof Is mentioned. By blending these moisturizers, more excellent whitening and / or skin beautifying effects are exhibited,
It is possible to realize transparent skin. Note that the names in parentheses are plant aliases, crude drug names, and the like.

The blood circulation promoting agent is used for the purpose of promoting melanin excretion by stimulating the blood flow in the skin, and includes Arnica extract, capsicum tincture, ginkgo biloba extract, tocopherol acetate, γ-oryzanol, etc., or a mixture thereof. Examples of the enzyme include lipase and papain. By blending these, more excellent whitening and / or skin beautifying effect can be exhibited.

Further, the external preparation for skin of the present invention contains, in addition to the above-mentioned components, a film-forming agent, a resin, a clathrate compound, a deodorant, etc., as long as the effects of the present invention are not impaired.
Salts, cooling agents, extracts derived from plants / animals / microorganisms, astringents, antiseborrheic agents, chelating agents, keratolytic agents, enzymes, hormones, vitamins and the like can also be added.

[0053]

The present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to the following examples.

(Example 1: Purified water extract of Ammalok) Mixed cut product of whole plant of Ammalok (Phyllanthus emblica L.) 10
g was immersed in 100 mL of purified water and extracted at room temperature for 3 days. The obtained extract was filtered to obtain an extract as a filtrate. The dry solid content of the extract was 3.6%.

Example 2: Extract of Ammalok with a mixed solvent of ethyl alcohol and water Ammalok (Phyllanthus)
10 g of a mixed cut product of whole grass of emblica L.) was mixed with a mixed solvent of purified water and ethyl alcohol (volume ratio was 1: 1) 10
It was immersed in 0 mL and extracted at room temperature for 3 days. The obtained extract was filtered to obtain an extract as a filtrate. The dry solid content of the extract was 1.2%.

Example 3 Ammalok Ethyl Alcohol Extract 10 g of mixed cut whole plant of Ammalok (Phyllanthus emblica L.) was immersed in 100 mL of ethyl alcohol and extracted at room temperature for 3 days. The obtained extract was filtered to obtain an extract as a filtrate. The dry solid content of the extract was 0.5%.

(Example 4: Ammalok fruit juice) Ammalok (Phy
10 g of llanthus emblica L.) fruit was pressed to obtain fruit juice. This fruit juice was left at room temperature for 3 days and then filtered to obtain fruit juice. The dry solid content of this fruit juice was 5.2%.

Example 5 Ammalok Compressed Oil Ammalok (P
10 g of seeds of hyllanthus emblica L.) were pressed to obtain a pressed oil. This compressed oil was left standing at room temperature for 3 days and then filtered and used.

Example 6: Ammalok Fruit Water Ammalok (P
10 g of the fruit of hyllanthus emblica L.) was pressed to obtain fruit juice. This fruit juice was heated and concentrated to obtain fruit water as distilled water generated at that time.

Example 7: Ammalok Steam Distillate About 10 g of fruits of Ammalok (Phyllanthus emblica L.),
Steam distillation was performed according to a conventional method, and the aqueous layer of the obtained distillate was collected and then filtered to obtain a steam distillate.

(Example 8: Yokuinin Extract) 10 g of Yokuinin (JP) was immersed in 100 mL of a mixed solvent of water and ethyl alcohol (volume ratio 3: 7) and left at room temperature for 3 days for extraction. It was The extract obtained is filtered,
Yokuinin extract was obtained as the filtrate. At this time, the dry solid content of the Yokuinin extract was 0.8%.

(Example 9: Inhibition of melanin production by cell culture and cell viability test) Mouse-derived B16 melanoma cultured cells were used. 10% FB on two 6-hole dishes
An appropriate amount of S-containing MEM medium was taken, B16 melanoma cells were seeded, and left standing in an atmosphere at a temperature of 37 ° C. and a carbon dioxide concentration of 5%. The next day, the extract of Ammarok obtained in Examples 1-5, fruit juice and seed oil were added to a final concentration of 0 (control), 10,
The sample preparation solution was added and mixed so as to have a concentration of 30, 100, and 1000 μg / mL. Change the medium on the 5th day of culture,
The sample preparation solution was added again. The next day, the medium was removed, and the cells were washed with phosphate buffer for one dish,
The whiteness of the collected and cultured B16 melanoma cells was evaluated according to the following criteria. Further, as a comparative example, the same test was carried out on the Yokuinin extract obtained in Example 8, which is already known to have a melanin production inhibitory action.

(Criteria) ++: Very white with respect to the control. +: Clearly white with respect to the control. ±: slightly whiter than the control. -: The same black color as the control.

After the cells of the remaining one dish were fixed with formalin, 1% crystal violet solution was added and stained. The cell viability for each sample concentration was measured with a monoserator (Olympus). The above results are shown in Table 1.

[0065]

[Table 1]

As is clear from the results shown in Table 1, it was confirmed that the components derived from ammalok had a high ability to suppress melanin production and had low toxicity to B16 melanoma cultured cells. Therefore, when this is applied to the skin, it exerts an extremely excellent melanin production-suppressing action, and effectively suppresses skin blackening due to sunburn, spots, freckles, and the like, and is expected to have a whitening and beautiful skin effect.

(Example 10: Cream) Creams having the compositions shown in Table 2 below were prepared by the following methods. First, components (1) to (6) shown in Table 2 are mixed and heated to 70 ° C.
Maintained at. This mixture was mixed with the ingredients (1
Part (5) was added, and (7) to (13) and (14) dissolved in the balance of the component (15) were further mixed. After that, it was cooled to obtain creams 1 to 5 of the present invention and comparative creams 1 and 2.

With respect to each of the obtained creams, the whitening effect and the skin beautifying effect were evaluated by the following test methods. For each test cream product, 15 women aged 27 to 54 were used as a panel. The test period is 12 weeks, and twice a day, morning and night.
After washing the face, an appropriate amount of the test cream was applied to the face, and the whitening and skin-cleansing effects of the application were evaluated according to the following criteria. The results are shown in Table 2. The numbers in the table indicate the number of people. <Evaluation><Contents> Effectiveness The dullness of the skin became inconspicuous. Somewhat effective The dullness of the skin became less noticeable. Ineffective No change from before use.

[0069]

[Table 2]

As is clear from the results shown in Table 2, the cream of the product of the present invention containing the ingredient derived from ammalok can prevent and improve "dullness" of the skin by applying these to the skin, and whitening the skin. And it became clear that there was a beautiful skin effect.

(Example 11: Cream) Inventive creams and comparative creams having the compositions shown in Table 3 below were prepared by the following methods. Components (1) to (6), (10),
(13) and (14) were mixed and heated to maintain 70 ° C. To this mixture was added component (16) maintained at 70 ° C.
Was added, and components (9), (11), (12) and (15) dissolved in the balance of components (7) to (8) and (16) were further mixed. Then, it cooled and obtained this invention cream 6-11 and the comparative cream 3-7.

For each of the creams obtained, the whitening and skin-lightening effects were evaluated by the same test method as in Example 10 and on the same basis. The evaluation results are shown in Table 3.

[0073]

[Table 3]

As is clear from the results shown in Table 3, the cream of the present invention 6 containing the juice of Ammalok and a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activating agent or an ultraviolet inhibitor in combination. No. 11 synergistically exerts an effect of preventing and improving "dullness" of the skin, etc., and exhibits superior whitening and beautiful skin effects as compared with the case of applying an external preparation containing only the juice of Ammalok alone. It became clear.

(Example 12: Lotion) The following components (1) to
The solution in which (6) was mixed and dissolved and the solution in which components (7) to (10) were mixed and dissolved were mixed and made uniform to obtain a lotion. (Component) (%) (1) Glycerin 10.0 (2) 1,3-Butylene glycol 6.0 (3) Steam distillate of Ammarok * 1 30.0 (4) Citric acid 0.1 (5) Sodium acid salt 0.3 (6) Purified water Residual amount (7) Polyoxyethylene (60 EO) hydrogenated castor oil 0.5 (8) Ethyl alcohol 8.0 (9) Methyl paraoxybenzoate 0.1 (10 ) Fragrance suitable amount * 1 Produced in Example 7

(Example 13: Lotion) The following components (1) to
A solution obtained by mixing and dissolving (7) and the following components (8) to (1
The solution obtained by mixing and dissolving 1) was mixed and homogenized to obtain a lotion. (Component) (%) (1) Glycerin 10.0 (2) 1,3-butylene glycol 6.0 (3) Ammarok fruit water * 1 10.0 (4) Seaweed extract * 2 0.5 (5 ) Citric acid 0.1 (6) Sodium citrate 0.3 (7) Purified water Remaining amount (8) Polyoxyethylene (60 EO) Hydrogenated castor oil 0.5 (9) Ethyl alcohol 8.0 (10) ) Phenoxyethanol 0.5 (11) Fragrance Suitable amount * 1 The one produced in Example 6 * 2 Made by Philippe Rockley

(Example 14: Emulsion) The following components (13) to (1)
To the mixture obtained by heating and mixing 7) at 70 ° C., a mixture obtained by heating and mixing the following components (1) to (12) at 70 ° C. was added and uniformly emulsified. Furthermore, after cooling (1
8) to (22) were added and uniformly mixed to obtain an emulsion. (Component) (%) (1) sorbitan monostearate 0.3 (2) polyoxyethylene sorbitan monooleate (20.EO) 0.1 (3) lipophilic glyceryl monostearate 0.2 (4) Stearic acid 0.5 (5) Cetanol 0.5 (6) Squalane 3.0 (7) Liquid paraffin 4.0 (8) Glyceryl tri-2-ethylhexanoate 2.0 (9) Methylpolysiloxane 1 0.0 (10) Hydrogenated soybean phospholipid 0.1 (11) Acetic acid dl-α-tocopherol * 1 0.05 (12) Methyl paraoxybenzoate 0.1 (13) Carboxyvinyl polymer 0.1 (14) Water Sodium oxide 0.05 (15) Glycerin 5.0 (16) 1,3-butylene glycol 7.0 (17) Purified water Residual amount (18) Ethyl alcohol 5.0 (19) 50% ethyl alcohol extract of Ammalok * 2 0.1 (20) Placenta extract * 3 3.0 (21) Porous silica 3.0 (22) Perfume proper amount * 1 Eisai * 2 Example 2 Manufactured by Nichirei

(Example 15: Emulsion) The following components (13) to (1)
To the mixture obtained by heating and mixing 7) at 70 ° C., a mixture obtained by heating and mixing the following components (1) to (12) at 70 ° C. was added and uniformly emulsified. After cooling (18) ~ (2
2) was added and mixed uniformly to obtain an emulsion. (Component) (%) (1) sorbitan monostearate 0.3 (2) polyoxyethylene sorbitan monooleate (20.EO) 0.1 (3) lipophilic glyceryl monostearate 0.2 (4) Stearic acid 0.5 (5) Cetanol 0.5 (6) Squalane 3.0 (7) Liquid paraffin 4.0 (8) Glyceryl tri-2-ethylhexanoate 2.0 (9) Methylpolysiloxane 1 .0 (10) Hydrogenated soybean phospholipid 0.1 (11) Astaxanthin * 1 0.2 (12) Methyl paraoxybenzoate 0.1 (13) Carboxyvinyl polymer 0.1 (14) Sodium hydroxide 0.05 (15) Glycerin 5.0 (16) 1,3-Butylene glycol 7.0 (17) Purified water Remaining amount (18) Ethyl alcohol 5.0 (19) Anne Roku's ethyl alcohol extract * 2 0.1 (20) Yeast extract * 3 3.0 (21) Porous silica 3.0 (22) Perfume proper amount * 1 Sigma * 2 Produced in Example 3 * 3 Made by Maruzen Pharmaceutical Co., Ltd.

The lotions or emulsions of Examples 12 to 15 are all excellent in stability over time, and when applied to the skin, they prevent "dullness", spots and freckles on the skin due to sunburn,
It was a lotion and milky lotion that gave a transparent and beautiful skin.

(Example 16: Ointment) The following components (5) and (6)
And a part of (7) was heated and mixed, and the mixture maintained at 75 ° C. was heated and mixed with the following components (1) to (4), and then heated to 75 ° C.
The mixture was gradually added to the mixture maintained at, and the components (8) and (9) dissolved in the balance of the component (7) were added while cooling the mixture to obtain an ointment. (Component) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) dl-α-tocopherol * 1 0.2 (4) Phenoxyethanol 0.5 (5) Triethanolamine 2.0 (6) Glycerin 5.0 (7) Purified water Remainder (8) Pressed oil of Ammarok * 2 1.0 (9) Dipotassium glycyrrhizinate * 3 0.5 * 1 Eisai * 2 Produced in Example 5 * 3 Made by Nippon Roche

(Example 17: Ointment) (Production method) A part of the following components (4), (5) and (6) was heated and mixed, and the mixture maintained at 75 ° C was used as components (1) to (5).
(3) was mixed by heating, gradually added to the mixture maintained at 75 ° C., and while cooling, (7) to (9) dissolved in the rest of (6) were added to obtain an ointment. (Component) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Methyl paraoxybenzoate 0.1 (4) Triethanolamine 2.0 (5) Glycerin 5.0 (6) Purified water Remaining amount (7) Ammalok's ethyl alcohol extract * 1 1.0 (8) Ginkgo biloba extract * 2 0.3 (9) Sodium pyrrolidonecarboxylate * 3 0.3 * 1 Prepared in Example 3 * 2 Made by Tokiwa Plant Chemistry Research Institute * 3 Made by Ajinomoto Co.

The ointments of Examples 16 and 17 were excellent in stability over time, and when applied to the skin, the ointment prevented "dullness" of the skin, spots and freckles and making the skin beautiful and transparent.

(Example 18: Pack) The following components (1) to
(5) and (9) were mixed, heated to 70 ° C., and stirred to obtain a mixture. The mixture obtained by mixing (6) and (7) was mixed with this mixture, and after cooling, (8) and (10) were uniformly dispersed to obtain a pack. (Component) (%) (1) Polyvinyl alcohol 15.0 (2) Silicic anhydride 0.5 (3) Polyethylene glycol 0.5 (4) Polyoxypropylene methyl glucoside 5.0 (5) Glycerin 5.0 ( 6) Ethyl alcohol 20.0 (7) Methyl paraoxybenzoate 0.1 (8) Ammarok fruit juice * 1 0.1 (9) Ammarok steam distillate * 2 Remaining amount (10) Perfume proper amount * 1 Manufactured * 2 Manufactured in Example 7

(Example 19: Pack) The following components (1) to
(7) was mixed, heated to 70 ° C., and stirred to obtain a mixture. The mixture obtained by mixing the components (8) and (9) was added to this mixture, and after cooling, the following components (10) to
(13) was uniformly dispersed to obtain a pack. (Component) (%) (1) Polyvinyl alcohol 15.0 (2) Silicic anhydride 0.5 (3) Polyethylene glycol 0.5 (4) Polyoxypropylene methyl glucoside 5.0 (5) Glycerin 5.0 ( 6) Ammalok purified water extract * 2 Remaining amount (7) Deep water * 1 10.0 (8) Ethyl alcohol 20.0 (9) Phenoxyethanol 0.5 (10) Ammalok 50% ethyl alcohol extract * 3 0.2 (11) Yokuinin extract * 4 0.5 (12) Wheat extract * 5 0.5 (13) Perfume Suitable amount * 1 Maruzen Pharmaceutical Co., Ltd. * 2 Manufactured in Example 1 * 3 Manufactured in Example 2 * 4 Made by Maruzen Pharmaceutical Co., Ltd. * 5 Made by Seiwa Kasei Co., Ltd.

Examples 18 and 19 were excellent in stability over time, and when applied to the skin, they were a pack which prevented "dullness" and stains on the skin and making the skin transparent and beautiful.

(Example 20: Liquid foundation) The following components (13) to (18) were added to a solution in which the following components (1) to (7) were mixed and dissolved, and the mixture was uniformly mixed and maintained at 70 ° C. The components (8) to (12) were uniformly dissolved and added to the solution maintained at 70 ° C. to uniformly emulsify this solution. After cooling the emulsion, the following components (19) to (22)
Was added to obtain a liquid foundation. (Component) (%) (1) Liquid lanolin 2.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Self-emulsifying glycerin monostearate 1.0 (6) 2-Ethylhexyl paramethoxycinnamate 8.0 (7) Methyl paraoxybenzoate 0.1 (8) Glycerin 5.0 (9) Triethanolamine 1.0 (10) Carboxymethylcellulose 0.2 ( 11) Bentonite 0.5 (12) Purified water Remaining amount (13) Titanium oxide 6.0 (14) Fine particle titanium oxide 2.0 (15) Fine particle zinc oxide 5.0 (16) Mica 2.0 (17) Talc 4.0 (18) Colored pigment 4.0 (19) Ammarok pressed oil * 1 0.01 (20) Licorice extract * 2 0.5 (21) Nicotinic acid amide * 3 0.5 (22) ) Perfume * 1 Produced in Example 5 * 2 Maruzen Pharmaceuticals * 3 Sigma

(Example 21: Liquid foundation) The following components (15) to (20) were added to a solution in which the following components (1) to (9) were mixed and dissolved, and the mixture was maintained at 70 ° C and uniformly mixed to obtain a solution. Got This solution was added to a solution prepared by uniformly dissolving (10) to (14) and maintaining the temperature at 70 ° C. to uniformly emulsify the solution. After cooling this emulsion, (21) to (23)
Was added to obtain a liquid foundation. (Component) (%) (1) Liquid lanolin 2.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Self-emulsifying glycerin monostearate 1.0 (6) 2-Ethylhexyl paramethoxycinnamate 8.0 (7) 4-tert-Butyl-4′-methoxydibenzoylmethane 2.0 (8) Retinol palmitate * 1 0.2 (9) Paraoxybenzoic acid Methyl acid 0.1 (10) Glycerin 5.0 (11) Triethanolamine 1.0 (12) Carboxymethyl cellulose 0.2 (13) Bentonite 0.5 (14) Purified water Remaining amount (15) Titanium oxide 6. 0 (16) Fine particle titanium oxide 2.0 (17) Fine particle zinc oxide 5.0 (18) Mica 2.0 (19) Talc 4.0 (20) Color pigment 4.0 (2 1) Ethyl alcohol extract of Ammalok * 2 0.2 (22) Magnesium L-ascorbyl phosphate * 3 0.3 (23) Perfume suitable amount * 1 Made by Nippon Roche * 2 Produced in Example 3 * 3 Nikko Made by Chemicals

(Example 22: Sunscreen emulsion) Component (1) was added to a dispersion liquid in which the following components (1) to (11) were mixed and dispersed.
A solution obtained by mixing 2) to (15) was added to uniformly emulsify. Components (16) and (17) were added to this emulsion to obtain a sunscreen emulsion. (Component) (%) (1) Polyoxyalkylene-modified organopolysiloxane 1.0 (2) Dimethylpolysiloxane 5.0 (3) Octamethylcyclotetrasiloxane 20.0 (4) Isotridecyl isononanoate 5.0 (5 ) 2-Ethylhexyl paramethoxycinnamate 5.0 (6) Methyl paraoxybenzoate 0.1 (7) Fragrance (8) Silicon treated fine particles titanium oxide 10.0 (9) Silicon treated fine particles zinc oxide 10.0 (10) Polystyrene powder 3.0 (11) Trimethylsiloxysilicic acid 0.5 (12) Dipropylene glycol 3.0 (13) Ethyl alcohol 10.0 (14) Purified water Residual amount (15) Salt 0.2 ( 16) Ammalok purified water extract * 1 2.0 (17) Green tea extract * 2 3.0 * 1 Produced in Example 1 * 2 Zen Pharmaceutical Co., Ltd.

(Example 23: Sunscreen Emulsion) To a dispersion liquid obtained by mixing and dispersing the following components (1) to (11), a solution obtained by mixing the following components (12) to (15) was added to uniformly emulsify. did. The following components (16) to (18) were added to this emulsion to obtain a sunscreen emulsion. (Component) (%) (1) Polyoxyalkylene-modified organopolysiloxane 1.0 (2) Dimethylpolysiloxane 5.0 (3) Octamethylcyclotetrasiloxane 20.0 (4) Isotridecyl isononanoate 5.0 (5 ) 2-Ethylhexyl paramethoxycinnamate 10.0 (6) Methyl paraoxybenzoate 0.1 (7) Fragrance (8) Silicon treated fine particles titanium oxide 8.0 (9) Silicon treated fine particles zinc oxide 7.0 (10) Polystyrene powder 3.0 (11) Trimethylsiloxysilicic acid 0.5 (12) Dipropylene glycol 3.0 (13) Ethyl alcohol 10.0 (14) Purified water Residual amount (15) Salt 0.2 ( 16) 50% ethyl alcohol extract of Ammalok * 1 1.0 (17) Phosphoric acid-L-ascorbyl magnesium * 2 3.0 (18) Coix extract * 3 0.5 * 1 Example 2 as produced in * 2 Nikko Chemicals Co., Ltd. * 3 Maruzen Pharmaceuticals Co., Ltd.

Examples 20 to 23 were liquid foundations and sunscreen emulsions which were excellent in stability over time, and when applied to the skin, they were excellent in the effect of preventing darkening of the skin due to sunburn and the like and stains and freckles.

[0091]

EFFECTS OF THE INVENTION The component derived from ammalok contained in the external preparation for skin of the present invention has a melanin production inhibitory effect, exerts a high inhibitory effect on pigmentation, and reduces skin dullness, sunburn and other skin damage. It is effective in preventing and improving blackening, stains and freckles. Therefore, the external preparation for skin of the present invention is
It can be advantageously used for cosmetics and pharmaceuticals for whitening and / or beautiful skin.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ identification code FI theme code (reference) A61K 7/42 A61K 7/42 7/48 7/48 35/78 35/78 L A61P 17/00 A61P 17 / 00 17/16 17/16 (72) Inventor Misako Kobayashi 48-18 Sakaemachi, Kita-ku, Tokyo Kose Co., Ltd. Research Division (72) Inventor Kazuo Hirose 3-5-20, Tagawa, Yodogawa-ku, Osaka-shi, Osaka No. Inabatake Co., Ltd. (72) Inventor Shinichi Matsumura 3-5-20 Tagawa, Yodogawa-ku, Osaka City, Osaka Prefecture In-field Co., Ltd. AC102 AC122 AC152 AC242 AC302 AC342 AC422 AC432 AC442 AC482 AC542 AC642 AC912 AD022 AD042 AD092 AD112 AD272 AD392 AD512 AD532 AD572 AD642 AD662 BB46 BB47 BB60 CC04 CC05 CC07 DD22 DD23 DD31 FF01 4C088 AB46 AC04 BA07 BA09 CA02 CA05 MA03 MA17 MA22 MA28 MA63 NA14 ZA89

Claims (10)

[Claims] 1. An external preparation for skin containing an ingredient derived from Ammalok (Phyllanthus emblica L.). 2. The external skin preparation according to claim 1, which contains an extract of Ammalok as the ingredient derived from Ammalok. 3. The external skin preparation according to claim 1, which contains a solvent extract of Ammalok as the ingredient derived from Ammalok. 4. The external skin preparation according to claim 1, which contains a steam distillate of ammalok as the ammalok-derived component. 5. The external preparation for skin according to claim 1, wherein the component derived from Ammalok is juice of Ammalok. 6. The external preparation for skin according to claim 1, wherein the component derived from Ammalok is fruit water of Ammalok. 7. The external preparation for skin according to claim 1, wherein the component derived from Ammalok is a pressed oil of Ammarok seeds. 8. The external preparation for skin according to any one of claims 1 to 7, which contains the component derived from Ammalok as a whitening and / or skin beautifying component. 9. A whitening agent, an antioxidant, an anti-inflammatory agent,
The external preparation for skin according to any one of claims 1 to 8, which contains at least one medicinal component selected from the group consisting of a cell activator and an ultraviolet protective agent. 10. The external preparation for skin according to any one of claims 1 to 9, which contains the component derived from ammalok as a melanin production inhibitor.