JP2000136142A - Antiallergic agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new safe antiallergic agent, histamine release inhibitor or cosmetic composition. SOLUTION: An antiallergic agent, histamine release inhibitor or cosmetic composition contains the extract of one or more plants selected from Agave sisalana Perr.; A.rigida Mill., Agave americana L. and Forsythia suspensa Vahl. The agents have a histamine release-inhibiting action, and can be used for preventing and treating skins and scalps having allergic dermatitis diseases (for example, flare, eczema, dropsy and swelling) and troubles such as atopic dermatitis, skin roughness and dry skins. The plant extract can further be utilized for other general foods.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an antiallergic agent containing at least one plant extract selected from sisal, agave, and forsythia, specifically, a histamine release inhibitor or a combination thereof. Allergic
An effective and highly safe drug or quasi-drug for the prevention and improvement of skin and scalp problems such as atopic skin inflammatory diseases (eg, redness, eczema, edema, swelling), rough and dry skin The present invention relates to application to various cosmetic compositions in the cosmetics field.

[0002] The field of application is various cosmetic compositions, for example, various external preparations (including preparations for animals) in general, and specifically, ampoules,
Capsule, pill, tablet, powder, granule, solid,
Liquid, gel or foam 1) pharmaceuticals, 2) quasi-drugs, 3) topical or systemic skin cosmetics (eg, lotions, emulsions, creams, ointments, lotions, oils, packs, etc.) Basic cosmetics, facial cleansers and skin cleansers, hair removers,
Hair removal agent, shaving treatment fee, after shave lotion,
Pre-show lotion, shaving cream, etc.), 4) medicinal or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent solutions, hair dyes, hair dressings, hair tonics) , Hair growth and hair restoration, etc.), 6) bath agents used in bath water, 7) other liquid odor / odor control agents, sanitary goods, sanitary cotton, wet tissues, etc.

[0003]

2. Description of the Related Art Today, owing to worsening environmental conditions, changes in lifestyles, and increased stress accompanying the complication of social life, hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria due to drugs, etc. More and more people suffer from allergic diseases, rough skin, dry skin and the like. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, with its increase being sought in not only children but also in a wide range of ages up to adults.

[0004] In order to eliminate foreign substances (antigens such as bacteria, pollen, mites, etc.) that have entered the body, the body must protect the body by producing biological components (antibodies, lymphocytes, etc.) against it. It has an immune function that works. However, sometimes the reaction becomes too sensitive and harmful to the body,
It can cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into immediate type and delayed type.

[0005] Among allergic reactions, the frequency of onset is high, which is immediate, and is mainly a reaction involving immunoglobulin E (IgE) antibodies. This IgE is produced against allergens that have entered the body and has a strong effector effect on mast cells and basophils. Mast cells and basophils (a type of leukocyte) Cells having granules containing pharmacologically active amines such as serotonin, the former being present around blood vessels and connective tissues, and the latter being present in blood. On these cell membranes, a receptor that binds an IgE antibody is present and has a property of strongly binding to the IgE antibody, and for an IgE antibody bound to mast cells or basophils,
When the same type of allergen binds again, a number of active substances such as histamine and serotonin are released from these cells with degranulation, causing various allergic symptoms, and itching and redness or blistering rash (urticaria) on the skin. Symptoms such as inflammation of the nose and eyes that cause itching and itchy secretions of nasal discharge and tears, or symptoms of bronchial congestion and dyspnea attacks (bronchial asthma) Classified as an allergic disease by type.

[0006] Immediate allergies can be roughly classified into three stages, and each stage is classified according to the point of action. Attempts are made to prevent, alleviate or treat allergic diseases by administering drugs. I have been. That is, when an exogenous antigen enters the body, an immunocompetent cell line produces an IgE antibody, and the IgE antibody is distributed in airway, skin, gastrointestinal organs and other mast cells, or in the blood. Sensitization is established by sticking to basophils.
This is the reaction referred to as the first step.

Next, when the sensitized cells are again contacted with an antigen, the cells undergo morphological changes such as vacuolation, swelling, and degranulation, and release chemical transmitters such as histamine, serotonin, and SRS-A. I do. This is the second stage reaction.

[0008] The released chemical messenger acts on contraction of smooth muscle such as bronchial muscle and gastrointestinal tract, enhancement of capillary permeability, migration of neutrophils, aggregation of platelets, and the like. The process of developing allergic symptoms such as gastrointestinal allergy accompanied by diarrhea, nasal allergy, and urticaria is the third stage reaction.

Therefore, in a narrow sense, drugs acting in the first and second steps are prophylactics for allergic reactions and
Those acting at the stage can be considered as symptomatic treatments. Currently, the most active research on antiallergic drugs is the development of drugs that suppress this second stage.

[0010]

Many of the conventionally used antiallergic drugs are drugs relating to diseases caused by an immediate allergic reaction whose action point is relatively clear. Examples include antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines, all of which are contrasting therapeutic agents that act in the third stage. And
Most of them are synthetic drugs, and have a problem in side effects.

On the other hand, currently the most active research on antiallergic agents involved in immediate-type allergic diseases, drugs that suppress the release of chemical mediators and exhibit an antagonistic effect on the released chemical mediators The development of drugs that suppress the second stage, such as drugs, has not yet been found to have sufficient efficacy.

[0012]

[Means for Solving the Problems] In view of such circumstances,
The present inventors have attempted to screen a substance that is excellent in antiallergic action and has no side effects and is relieved to the human body and skin from natural plants. As a result, it was confirmed that the extracts of sisal, agave, and forsythia were highly safe and had a histamine release inhibitory action. Therefore, use as a histamine release inhibitor. In addition, allergic skin inflammatory diseases (eg, redness, edema, eczema, etc.) comprising these plant extracts,
The present invention has been completed by providing a safe cosmetic composition excellent in prevention and improvement of skin and scalp troubles such as atopic dermatitis or rough and dry skin.

[0013]

DETAILED DESCRIPTION OF THE INVENTION "Agave" used in the present invention is a plant of the family Agave (Agavaceae) or the genus Agave (Agave): Aono agave (Agave)
americana L.), whole plant, fruit, pericarp, ears, flowers, leaves,
Branches, stems or trunks, bark, rhizomes, root bark, roots, tubers are used, but in addition, congener species of Fukurin agave (A. americana L. var marginata HORT.), Ayufisanoyuki (A. filifera Salm) .cv.Compacta), Yuki Sasano (A.victoriae-reginae T.Moore), Lysine (A.pota
torumZucc.) can also be used.

"Sisal" refers to the genus Agave (Agav
Plant e): Sisal Asa (Agave sisalana Perr .; A.rigi)
da Mill.), the whole plant, fruit, pericarp, ears, flowers, leaves, branches,
Use stems, stems, bark, rhizomes, root bark, roots, tuberous roots, but also other species of the same species, A. cana
tala Roxb.), Heneken (A. fourcroydes Lem.) and the like can also be used.

"Forsythia (forsythia)" is a plant of the family Oleaceae, Forsythia Vahl: forsythia suspensa Vahl or forsythia viridissima Lindl. In addition, the same genera as those of the same species can be used, such as F. japonica Makino, Korean Forsythia (F. koreana (Rehd.)), And F. ovata Nakai fruit, pericarp, and spikelets. .

The extracts of sisal, agave, and forsythia used in the present invention include various parts of each plant (whole plant, fruit, pericarp, pericarp, flower, leaf, branch, stem or stem,
Bark, rhizome, root bark, root, etc.) as it is or after crushing and squeezing. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl alcohol. Esters such as ether, dioxane, acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more. It can be used even when the objects are combined.

The plant extracts of sisal, agave, and forsythia are prepared by arbitrarily drying, concentrating, or diluting according to the type and form of the antiallergic agent, histamine release inhibitor, and cosmetic composition to be applied. Just do it.

The production method is not particularly limited, but is usually within the range of the boiling point of the solvent at normal temperature to normal pressure. After extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, purification treatment such as deodorization and decolorization may be added as far as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The plant extracts of sisal, agave, and rengyong of the present invention can be added to antiallergic agents, histamine release inhibitors, and cosmetic compositions. Agent, histamine release inhibitor, the type and quality of the cosmetic composition, the degree of expected action, and slightly differ, and usually 0.00
1% by weight or more (hereinafter, represented by weight%), preferably 0.1% by weight.
2-20% is good. If the amount is less than 0.001%, the effect cannot be expected sufficiently.

The antiallergic agent, histamine release inhibitor and cosmetic composition of the present invention, if necessary, in addition to the above-mentioned essential components, can be used as pharmaceuticals and quasi-drugs within a range not to impair the effects of the present invention. It can be produced by arbitrarily selecting and using components and additives used in preparations such as products and cosmetics.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil , Mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.).

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, pristane and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethyl cellulose, methyl cellulose, carboxy Methylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, Vinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D)
3), dihydrotaxerol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U, etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are usually processed according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, hydrolysis, etc.). Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water or a water-soluble organic solvent (eg, ethanol) , Propylene glycol, 1,3-butylene glycol, etc.).
However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water, Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as flavoring, deodorizing, thickening, preserving, and buffering can be expected.

As a specific plant (crude) used as a raw material,
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Fuji), Aotsu Lafuji (Kibo Komi), Acacia, Akashoma (Akasho-ma), Akasugi Fruit, Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane
(Kanekane Akane), Ayajiou Jiou (Jihuang), Agi (Awei),
Akinire (Royu skin), Akebi (Kidori), Asa (Asako-jin), Malva Asagao or Asagao (Toshiboshi), Hydrangea (Hydrangea), Amacha (Amacha), Ashitaba (Asahi), Amana (Kojingi), Azuki (red azuki beans), acerola, asenyak
(Asenyaku), Anise, Abemaki fruit, Avocado, Ama, Amacha (sweet tea), Amachaworu, Amadokoro (Tamatake), Amigasa lily (Shellfish), Altea, Arnica, Aloe (luxe),
Aloe vera, angelica, apricot honganzu (almond jelly), ansokkou (benzuka), igakozorina (biliary head), rush (light heart grass), knotweed (tiger cane root), strawberry,
Fig (fructose) or its leaves, Ichihatsu (primary), Ichibi (Aoi-ko), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo leaves, Ginkgo), Itohimemegi (Enshi), Carob bean, Inuazuna (Teilexi), rice seed or Seed coat, Inodo seed, Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (Iwazuchi-chi-chi), oolong tea, fennel,
Uki-Yagara (Mitsuryo), Uguisukagura fruit, Himeuikyo, Turmeric (Utsukin), Duckweed (buoyant), Usubasaishin / Keirinsaishin (spicy), Usvenia oi, Useniitachioi, Utsubogusa (summer grass), Udo or Shishido
(Qang activity, independent activity, Tang activity), plum (Umeboshi) or its flesh, Vladimir, owaurushi (Kusaco peach), Unshu mandarin (Chen skin), Estragon, Ezocogi (Ezo Goka), Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake Mushrooms), Ebisugusa / Cassia tora (Kyoko), Elderberry fruit, Elemi, Eryngii (pre-rotus Erinji), Endu (Gossip, Gossip rice), Ogi-kibana-ohgi (Ogi), Ouren (Yoren), Great crow squirrel (caronine), Great swordfish (self-defense), Great psyllium (vehicle, front grass), Great hazel (Haruko), Great lance
Okera (white jujube), Obanaya shabushi fruit, Omihasashi hawthorn (Yamasato), Ousei (Narukoyuri, Kagikurumabanarukoyuri), Oohisasanoyuki, Sasanoyuki, barley (barley), Oohoshigusa (cereal grass), Oguruma (turning over), Fruits, Panax ginseng and Panax ginseng
(Ginseng), St. John's wort, St. John's wort, St. John's wort (Cutting grass), St. John's wort (continuous cut), Onomimomi (blue ear), Onigurumi, Oninoyagara (Tenma), Onyuri sasasayuri hakatayuri, Yonoh
(Hashihayu), Ominaeshi (losing sauce), Dutch mustard (Watercress), Dutch jelly, Dutch honeybee, olives (fruits, seeds, leaves), oregano, orange fruit or pericarp, silkworm (ripe yellow), cacao seeds, Oyster or its leaves
(Persimmon), Kazikazura (Hook), Cassia, Kasinaki Fruit
(Kozou), gajutsu (shazajutsu), kasiwa (shaki tree, kahaha), cascarilla, cascara sagrada, kanikusa (kinsato), kanokosou (valerian grass root), birch or weeping birch (white birch), pumpkin, capoknoki seeds, kapu Hokusansho (Gardened pepper), Cattail
(Bamboo), Chamomile and Roman chamomile, Camellia japonica (weed), Camucum / Duck, Duckweed (Our gourd), Callasbishaku (Midsummer), Raspberry, Guarana seeds, Callahoo (Thick), Karaya, Karin (Gourd), Garcinia , Kawatake mushroom, kawaranadeshiko (stone bamboo), Ezokawaranadeshiko (kumugi, kumuiko), kawagomugi (inchinko), kansui
(Sweet), licorice (licorice), cantaraasa, candelilla,
Kantou, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiro strawberry, Maple strawberry, European strawberry), Kiwi fruit, Kikarasuuri
(Kuroro root), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Shima kaniku, Drosophila), Catalpa (Azumi), Rigid ridge (Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe,
Peppermint, Kinna, Chinese linden (Shincona, Red linden), Yellowfin (Huangbashi), Gymnema sylvestre, Cabbage, Cabbage immature fruit, Cucumber, Gyoryu (Nishikawayanagi ・
Teriyaki), Kiraja saponaria, Kiraya, Kiran-sou (gold acne grass), kumquat fruit, betel, kinmizuki
(Sengaku grass), guava fruit, guayule, Quercus infectria (gallicia), cucumber nuts, wolfberry (mugi, gugi, gugi leaves, skeletal bark), cedar grass (Tenmen Fuyu), vine (kuzukon), camphor tree, gooseberry Fruits, gardenia, gardenia, black clover, kumazasa, black pine, horseradish, clara, bittersweet, cranberry fruit, chestnut or its skin, curculigo latifolia fruit, grapefruit, buckthorn, black crocodile (rescue) , Kurobana Hikiokoshi, Clove (cloves, cloves), Gumbinazuna (Sekimei, Sekimeishi), Kaigai (Ikutake, Ikutakeho),
Celosia (cow flower, rooster), bay laurel, kenashisarutoribara (Tsubukuryo, Yamakiko), gentian,
Gennoshoco (Old treasured grass), Koji / Tachibana / Obenimikan / Ponkan / Santara (Tachibana skin), Koushinbara (Monthly flower), Kouzuikka, Kozo fruit, Kocha (tea), Kouhone (river bone), Kohon (waramoto, Kara straw book), Koulyang, Cilantro fruit, Kou Ren (Kohren), Koganebana (Yellow Gon), Cowberry (Koshibachi), Coconut fruit, Goshyu (Gusyuyu), Goshoi strawberry (Ubonashi), Pepper (Hot pepper), Copaiba balsam, Coffee beans , Kobushi magnolia, burdock, burdock, burdock, sesame
(Sesame seeds), Sesame grass (Ginseng), Gomishi (Gomiko), Sanekazura Binankazura Matsubusa, Wheat (wheat), Rice
Rice bran (red bran, white bran), rice oil, cola, acuminata seeds,
Cola and vera seeds, Fenugreek fruit, Colombo, Kondurango, Kombu, Konjac, Comfrey (Finhari grass), Sakisima button (weird sen), Sakura (Yamazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyayamazakura, Someiyoshino, Takanezakura ), Leaves, flowers, fruits, bark (cherry bark), cherries, pomegranate, sasa, sasanqua, sagemodaka (sawashatsu), sweet potato, sugarcane, sugar beet, saccharomyces japonica, Saffron (Red safflower, West safflower), Pomelo fruit, Soapwort, Salmonberry fruit, Sarasinuma (Masahima), Salvia (Sage), Sawagikyo (Yamakona), Sawagurumi (Yamawomo), Sanshin ginseng (Three ginseng) , Sanshuyu (sanshuyu), sansho (sansho), Nzukon (Yamamamene), shea (karite), Shianoki fruit, shiitake mushrooms (shiitake),
Shion, Shikitsuri, Shikunshi, Shiso
Aodiso chirimenzo kamenendoji (Shiyo leaf, Shiso), rosewood, linden, Chinese pine, Chinese beetle (continuous forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, ossiloyshimeji, bunashimeji, shirotake mushroom) ,
Shajin (Shasan), Janohige (Bakumon winter), Juzudama, Palm fruit, Ginger (Ginger), Shobu (Iris, Iris root),
Shozuku fruit, white birch seed, white walnut butterfly seed, white adzuki bean (chicken bone grass), white iris (small iris), white pine flower, white nananten (southern fruit), cinconas sac sylbra, jinchoge (mizuka, mizuka flower, shencho flower), cinnamon , Watermelon (watermelon), honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acidic model), swimberry fruit, stevia, strawberry fruit, suzu psycho (Xucho Lord), horsetail
(Thorn), Purslane (Horse Tongue, Hen Tonen), Plum Fruit, Scots Pine Cones, Larix sylvestris, Scots Kizuta, Scotch Worm, Scots Pear, Scots Dandelion, Horse Chestnut (Maloney), Scots Pear Fruit, Atlantic snowfall, Atlantic elderberry (Elder), Japanese shrew (Juniper / Morimatsu), Yarrow (milfoil), Yeoubara, Yeouenbokuboku, Yeodori dorighi, Yeohwakae, Yeahwhawk, Yezowase , Hirohasenega, senega, seri, celery, senkyu (river cucumber), sendan, senburi (drug), senna fruit or leaves, senninso (great tate), souka (grass), buckwheat seeds, soba monoimo, rhubarb (daioh), Radish, soybean, Daidai (orange Skin, kikomi), takatodai (daigeki), takarababi (gull), dark sweet cherry fruit, hollyhock, hollyhock thyme (thyme, hundred scents), holly willow, tamarind seeds, onion, tamashiba (spicy), arachiki or its root bark, Tanjin (dansan), dandelion (gakko) or Shirobana dandelion and moko dandelion, dammar, cherry fruit, chigaya or its root (chinese), chikutsujin carrot (bamboo ginseng), chicory, Korean ginseng (gomiko), Korean ginseng (daisou) , Korean ginseng (Wuyi), Korean ginseng (carrot), Korean ginseng (Aiba), Choreimaitake (Irei), Tsukimisou, Tsukuritake (mushroom), Camellia, Camellia, Tsumekusa (lacquer grass), Camellia (Duckweed) Grass), Tsuruazuki
(Red azuki bean), tsuldokudami (what a crow), tsuruna (ban-an), tsujin carrot (four-leaf ginseng), tsuwabuki, deiko, teuchigurumi,
Duberry fruit, Tengusa, Tencha (Tencha), Tendai Yaku (Wakayaku), Pepper (Winter melon), Pepper (Pan pepper),
Touki (Toki), Calendula (marigold), Corn or corn hair (Nanban hair)
(Sadako), Toudondo (Ryubile), Tokusa (Pirates), Dokudami (Juyaku), Tokon (Stone), Toshishi, Mamedaoshi, Nenokazura, Tochu (Tonaka, Tonakaha), Ash (Hinata), Tomato, Tragant , Triacanthus seeds, Tormentilla, Dronoki, Trolo-aoi, Niseria berry fruit, Yam yam (Yamayaku), Nagikadada (Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natsumikan, Jujube (Daijutsu), Naniwaibara (Kanezakura) Nameko, Narco lily (yellow), peanut (peanut), Nanten (minamiminami), Nigaki (bitter tree), sagebrush (bitter berry), nutmegium, Kei Nikkei (cinnamon bark) Keishi (Keishi), Chinese chive (Nirako) , Elderberry (bone-attached tree) fruit / flower or foliage, garlic (garlic), nulde (fivefold), leek, thistle
(Ohi), Noibara (real fruit), Yarrow, Japanese radish (Maehu), Nobara, Nomomo, Palm, Pineapple fruit, Hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (Bone crushing), Hakusen (White ring skin), Huckleberry fruit, chickweed (red), hazel (haruko), hasidoro (roth root), basil, lotus (lotus, lotus, lotus),
Parsley (Netherlands jelly), naked mussels, batata, and hachik
Madake (bamboo-boiled), patchouli, mint (lightly loaded, lightly-leaved leaves), barley (yokuinin), hanasuge (chimbo), banana, hanahacka, hanabishi (situri, shisitsuri), vanilla bins, papaya, lycopodium (rat), hub Grass, paprika, hamago / mitsubahamago (vines), hamasuge (kosuke), hamabishi (ritsuko), hamanas (maikai flower),
Hamabofu (beach storm), hamamelis, rose (rose), agarita (aratake, white-bellied agaric, usukimolinokasa), parietaria, harunire (yellow, yu white skin, yu leaf),
Breadfruit, Hiougi (sun-dried), Lycopodium carrot (party party), pecan nut, giganbana (stone garlic, mulberry flower),
Hikiokoshi (prolonged life grass), Hishi (Hishimi), pistachio, beet, hitsuba (stone reed), hitsuneenida, hinotainokozuchi (cow knee), hinoki, hiba, castor, sunflower, bell pepper, hemigama (Kabamaritake) ,
(Hiromatsutake), Pimenta fruit, Juniper, Biancuum, Hydrangea fruit, Biloba mallow, Hiroha okinagusa (Hakuto oka), Loquat (Loquat, Loquat leaf), Betel wax (Large garment skin, Aretaroko), Scallop (Southern rattan), Fuki, Bukidan poppo (Winter flower, winter leaf), fujibakama (orchid grass), wisteria bean (tomato), grape fruit or pericarp, seeds and leaves, beech, sycamore mushroom (corbicula), Brazilian fern, Brazilian carrot, black currant fruit, blackberry , Plum fruit, furcellaria, blueberry (Prunus aegypti), prunes, blond psyllium, bundou (green beans), loofah, safflower (safflower), henneken, belladonna, berry fruits, peruvianberg, boysenberry fruits, boufu (windproof), spinach , Physalis (Torone), honoki (Japanese thick, magnolia), bokeh (gourd), hosoba Naokera (Aojutsu), Hosobabarengiku, Bodaiju (Bodai tree), Button (Peonies, Peony bark), Hops, Jojoba, White berry fruits, Hon Shimeji, Hon Onik (Nikujiro / Daigei),
Mizurutennansha (Tennan star), Maitake (Maitake),
Ephedra (mao), macadamia nut, macri (sea grass), maguwa (mulberry bark, mulberry leaf), magnolia splengeri, matatabi (kiten tate), matsukasa, matsuha, matsuhodo (bukuryo), mayolam (hanahanakka), malvanodazine (Sinner), mulberry fruit, quince, mango, mangosteen, manshu walnut, mandarin fruit, mannentake (reishi), citrus plant fruit (kikomi), mishimasaiko (saiko), mizokoshi
(Hanabe lotus), Misohagi (Chisenna), Mitsugashiwa, Mitsuba, Midorihakka, Mimosa, Myoga, Miracle fruit fruit, Myrrh, Mirobaran, Mukuge (Mokugei), Mukunoki, Mukuroji, Murasaki (purple root), Murasakisukibu and Omurasakisekibu ( Pearls), (Murasaki corn, swordfish)
(Mother grass), mebogi, melaleuca, melissa, melilot, melon fruit, sagebrush, mosouchiku, mokoko (wood incense), maple blossom, peach leaf (peach leaf), fruit
Seeds (peach kernels), bean sprouts, morello cherry fruits, moroheiya
(Burlap), yakawamaki yam, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yashabushi (arrow wheel) / Himeyashabushi / fruit of Obayashishabushi, peel, fruit ear, yayanagi, yatsude (octagonal metal plate), mistletoe
(Willow parasitism), willows (Sow willow, Tachi willow, weeping willow, red willow willow, cat willow, inukoriyanagi, kinuyanagi, kolyanagi, unryuyanagi, miyayamayanagi, yamayanagi, obayanagi, tyrikkinyanagi,
(Sweet willow, Dronoki), willow leaf, yabugarashi, yabukouji (purple gold beef), pokeweed (commercial land), yamahanoki (yamaharu), yamamomo (yellow plum skin), yamajomogi, eucalyptus, yukinoshita (tiger ear grass), yucca flebifolia, Yuzu fruit, lily, royal grass, mugwort (Aiba leaf), lime fruit, rye, lacanca fruit, raspberry leaf and fruit, lavender, longan (longan meat), ryocha (green tea), apple fruit, gentian, rubus suavisimus (sweeten), Litchi (Lichi, Lichi nucleus), lettuce (Chisha), red currant fruit, lemon fruit, lemongrass, astragalus,
Examples include wax palm, lokon (reed: Root), loganberry fruit, rosemary (mannenrow), rosehip (nobara), wasabi, and valerium (chiyu).

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaa nori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [Brown algae: Kombu algae: brown algae: brown algae: Kombu algae: brown algae: brown algae: brown seaweed: , Resiliconibu, hosomekobu, mishitishibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Onyxa, Obakusa, Kataobaxa, Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka, Tohkanota, Tojika , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Other algae such as green algae (Chlamydomonas spp .: Chlamydomonas sp., Akayukimo, Dunaliella spp .: Dunaliella spp., Chlorococcus spp .: Chlorococcus, Kwanomimo spp .: Kwanomimo spp., Volvox spp. Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asamidori ogusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: tamatamamo, iwata: husaiwata, suricogita, heraiwirata, crocodile, crocus Sakibutimimil, Nagamil, Hiramil, and Casanori:
Casa nori, Juzumo
Mizojuzumo, Mizuazumimo, Korekaete, Tsutsumimo, Kikkogusa: Kikkogusa, Hitoexa: Hitoexa, Hirohanohiegusa, Usuhitoexa, Motsuhitoe, Sayamidro, Genus spp.

Blue-green algae (Genus L .: L., L., L., L .: L., mushrooms,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp .: Namiami sp., Isogrape spp .: Isogrape,
Genus Isogawara, genus Isogasula, genus genus: Gunsenkurogashira, genus Kashirazaki, genus Kashirazaki, genus Muchimo: genus Muchimo, Hiramutimo, Kebelligsa, genus Amis. Artemisia spp.
Genus Matsumo: genus Matsumo, genus matsumo: genus sylvestris, genus okinawa, genus okinawa-mozuku, genus niseftomozuku: niseftomozuku, futomozuku: genus futomozuku, ishimozuku: ishimozuku, kuromo: kuromo, nisemozuku: genus, spruce, spruce Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Species of the genus Coleoptera, Tobacco planta, Laminaria genus: Laminaria genus: Habanomodo genus: Habanomodo genus, Habanori genus: Havanori, genus Habanori: genus Habanori, genus bukuro: common bukuro, Ezobukuro genus: Ezobukuro, Fukuronori genus: Fukuronori, Watanabe Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Turrum, Genus Anana: Genus Anastasia, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Genus Ligustrum, G. , Onikombu, Goheikombu, Nagakombu, Pea kelp, Ochimikombu, Torokombu genus: Torokombu, Antokume genus: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikomu: Genus Kikuishi, Nejirekomu: Neshilecomb, Kuroshiomeko : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Honamomaku, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizushimoku, Hahakimokum, Togemoku, Jolemoku, Saw-mokum, Obanoki-moku, Genus genus: Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Genus genus: Ushikenori, Funorinoushike, Genus Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: sodegarami, rattles: rattle, hiraragara, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, kurobana, kurobana, swordfish, swordfish, squirrel Genus: hibiroudo, himehibiroudo,
Genus genus: genus isensis, genus genus:
Genus spruce, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarequigusa: Nisekarequigusa, Okitsubara genus: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana: Genus Hosobanamino, Naminohanagosa, Coralthus Genus Ikawanokawa, Genus Kanokawa: Kinokawa, Genus Kaninote: Kaninote, Coralum: Coralum, Genus Mucadenori: Mucadenori, Sujimukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nuracusa, Chronulaxa, Stinging genus, Hirakintoki Genus: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus Otokinari, Genus genus Genus Nagaobane, Genus Funori: Hanafunori, Fukuronori, Makhunori, Karenikusa Genus: Kalexigusa, Tosakamaki Genus: Hosobanotokamaki, Hirohanotosakamodoroki, Yatsudegatotoka, Kurotosakamodoki, Nezashinokidoka, Nezashinokinusakada Genus: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuhono Oh, the genus Venice: genus Venice, genus Suskabeni: genus Suskebeni, genus Okamuragusa:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobaliso, Phyllophorus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizokonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge, genus: ssp.
Genus: crocodile, saimi, crocodile, crocus genus: genus genus: moss genus, genus cynosum: squid moss, hosoibonori, nobonori, kurohaginnansou genus: kurohaginnansou, akabaginnansou genus: akabaginnansou, genus genus: genus serrata The genus Thaliosa: The genus Thalassium, Hanasakura, The genus Scrophulari: The genus Scrophulari, Schikonori, The genus Hananoeda: Hanaeda, The genus Hirata: The genus Hirata goat, The genus Darus: The darth, Masagoshibari, Anadarus, The genus Webagusa, Benifukunori
Genus Fusinagi: Fussushinagi, Himefusushinagi, Hirohafushinagisagi, Satsumagiso Genus: Hirawaginagiso, Usubawaginagiso, Igis Genus: Igis, Keigisu, Harigigissu, Haneigisu, Amigusa, Egonomida, Chrysanthemum Genus, Genus genus Family: Habutaenori, Konohanori, Suzuronori, Usveni genus: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Sujiginu, Atubastinu, Hyasubanori: Kagiusubanori, Jaureusubanoli, Jareusubanoli
Genus Ayanishiki: Genus Ayanishiki, Genus Ayaginu: Genus Ayaginu, Genus Dadia: Enashidazia, Genus Shimadagia: Isohagi, Simadadia, Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moleutogusa, Genus Genus: Makuri, Yanaginori, Hanayana, Rana Salix var. Genus Isomegusa: Isomegusa, Suzinasugusa: Suzinasugusa, Isobashou Genus: Isobashou, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Scutellaria Rihiba, genus: genus kawamozuku, okamomozuku, himekamozuku, genus idiomyme: ideyugomegome, genus okitamozuku: genus okitimozuku,
Genus genus, genus chinorimo: chinorimo, genus genus: chisinori).

The axle algae (Characta spp., Rhododendron spp.,
Hossiturimo: Hossiturimo, Lichnotumnus, Flasksmo: Himefuramocha, Chaboflasmo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include a cockscomb extract, a cow / human placenta extract, a pig / cattle stomach, duodenum or intestinal extract or a decomposition product thereof, and a pig / cattle spleen extract. Products or their degradation products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin,
Hematin, heme, protohem, heme iron, etc.), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, rice ferment extract, rice bran extract, euglena extract, trehalose or a derivative thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorbing / blocking agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor Ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, placenta extract, silk peptide, plant extract (mulberry, corn, waremoko,
Artemisia, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odorisus, hawthorn, eucalyptus, american millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, life-extended grass, bellflower, toshishi, maikoboshi, kyoto, makko, senkyu, dokka Psycho, Bohu,
Hamabofu, Ogon, Peonies, Gennoshoko, Licorice, Fivefold, Aloe, Ginger, Safflower, Asenyaku).

(20) Melanin dye reduction / decomposition Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide and the like.

(21) Acceleration of turnover / cell activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.).

(22) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid and its salts, stearic acid esters, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo).

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-
Camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, licorice extract components, sicon extract, age extract extract and the like.

(27) Disinfectant / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethyl chloride Glycine solution, isopropylmethylphenol, triclosan, quinidine, etc.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, pyrrolidone carboxylic acid and its salts, lactic acid Sodium, Mini Sasanishiki extract, etc.

(29) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, show tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Antiandrogens Estrogen (eg, estrone, estradiol, ethinylestradiol), isoflavones, oxendrone, etc.

(31) Peripheral vascular blood flow promoter Vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(32) Local stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(33) Metabolic activators Photosensitizer 301, hinokitiol, pantothenic acid and its derivatives, allantoin, placental extract, biotin, pentadecanoic acid glyceride and the like.

(34) Antiseborrheic agents Pyridoxine and its derivatives, sulfur, vitamin B6 and the like.

(35) Keratolytic agents Resorcin, salicylic acid, lactic acid and the like.

(36) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(37) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaamino Phenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate,
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(38) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(39) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and plant proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, enzymes, and the like are listed, and when used in combination therewith, various additive and synergistic effects can be expected.

The dosage form of the antiallergic agent, histamine release inhibitor and cosmetic composition of the present invention is arbitrary, and may be capsule, powder, granule, solid, liquid, gel, foam, emulsion. It can be used by blending it in pharmaceuticals such as powder, cream, ointment, sheet, etc., quasi-drugs, and cosmetics for skin and hair.

Specifically, for example, external preparations, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, depilatory agents, depilatory agents, aftershave lotions , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth and hair growth products, etc., makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents In addition, it can be applied to various products such as toothpaste, mouth freshener / gargle, deodorant / deodorant, sanitary cotton, wet tissue, and can be used for general food / drinks.

The method for adding the antiallergic agent, histamine release inhibitor and cosmetic composition of the present invention to the cosmetic composition is as follows.
It may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0075]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) Sisal, agave,
100 g of each Forsythia plant, purified water (about 80 ° C)
For about 5 to 6 hours, followed by filtration to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 2.5% by weight).

(Production Example 2) Sisal, agave,
100 g of each forsythia plant is immersed in a 50% ethanol solution, extracted at room temperature for 3 to 7 days and nights, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 2.5% by weight).

(Production Example 3) Sisal, agave,
100 g of each forsythia plant is immersed in 70% ethanol solution or 30% 1,3-butylene glycol solution or 60% propylene glycol solution or purified water (about 30 ° C), and extracted at room temperature for 3-7 days and nights After filtering, about 1.0 kg of an extract (dry solid content: about 0.3 to 3.0% by weight) is obtained.

(Test 1) Histamine Release Inhibition Test In an immediate allergic reaction, a chemical mediator such as histamine is released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this study, histamine releasing reagent co
Test method for releasing histamine with mpound48 / 80 (J. Soc. C
osmet.Japan, Vol.25, No.4, P.246 (1992))
The extract obtained in Production Example 2 was examined.

(Test Method) a. The solvent was distilled off from the sample extract under reduced pressure, and then redissolved in purified water so that the solid content concentration became 0.01, 0.05, and 0.1% by weight, and used for the test. The same concentration of dipotassium glycyrrhizinate was used as a positive control. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / mL, and incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, and histamine released from the supernatant was extracted and purified.The color was developed with o-phthaldialdehyde, and the fluorescence absorbance at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm was measured. The histamine release inhibition rate was calculated by the following equation (Equation 1).

[0081]

## EQU1 ## Histamine suppression rate (%) = ｛1- (AC) /
(BC)｝ × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added in the presence of a sample in mast cells B: Fluorescence of histamine released when a histamine releasing agent was added to mast cells Intensity C: Fluorescence intensity of histamine naturally released from mast cells (A, B and C are measured values minus blind values)

[0082]

[Table 1]

(Test Results) As shown in Table 1, it was confirmed that the plant extracts of sisal, agave, and forsythia of the present invention have a high histamine release inhibitory action. Also, it has an excellent histamine release inhibitory action as compared with dipotassium glycyrrhizinate, and can be used as an antiallergic agent.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared with purified water so that the dry solid concentration was about 0.5% by weight. Japanese rabbits with female back shaved (female, 3 per group, weight 2.3kg)
Before and after). The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 3) Safety Test (2) Skin Cumulative Irritation Test Similarly, various plant extracts obtained in Production Examples 1 to 3 were added to purified water so that the dry solid concentration was about 0.5% by weight. Guinea pigs (female,
Once a day, 5 times a week on the skin of 3 animals per group, weight around 320g)
0.5 mL / animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indices. As a result, all animals were judged as negative without any erythema and edema over 2 weeks.

(Test 4) Safety test (3) Acute toxicity test Similarly, powders obtained by concentrating and drying the various plant extracts obtained in Production Examples 1 to 3 (dry solid content: about 1.0% by weight) )
Was orally administered to ddy mice (male and female, 5 mice / group, 5 weeks old), which had been fasted for 4 hours before the test, in an amount of 2,000 mg / kg.
The appearance and degree of toxicity symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days,
In addition, there was no abnormality in the dissection result. Therefore, LD50 is 2,
It was determined to be 000 mg / kg or more.

(Prescription examples) Preparation of antiallergic agent, histamine release inhibitor, cosmetic composition The following formulation examples are shown below according to the above evaluation results, and each formulation example is manufactured by a usual method in the manufacture of each product. And only the amount was shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. A: 50% ethanol extract of sisal B: 50% ethanol extract of agave C: 50% ethanol extract of forsythia * A Any one of C to 7.0 7.0 11. Appropriate amount of fragrance and preservative

(Formulation Example 2) Peel-off pack weight% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6: Sisal 50% ethanol extract 3.0 7: Agave 50 % Ethanol extract 1.0 8. Appropriate amount of fragrance and preservative 9. Residue to 100 with purified water

(Formulation Example 3) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Almond oil 15.0 5. Borax 0.5 6. Agave 50% 1,3-butylen glycol extract 2.0 7. Forsythia 50% ethanol extract 2.0 8. Appropriate amount of fragrance and preservative 9. Residual to make purified water 100

(Formulation Example 4) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Agave 30% ethanol extract 0.5 5. Sisal 1,3-butylene glycol extract 0.5 6. Forsythia extract 1.5 (Ethanol: 1,3-butylene glycol = 2: 1 extract) 7. Appropriate amount of pH adjuster 8. Preservative appropriate amount 9. Purified water 100

(Formulation Example 5) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Sisal 30% Fluorescent liquid extract 4.0 7. Agave 80% ethanol extract 4.0 8. Perfume and preservatives qs 9 Purified water 100

(Formulation Example 6) Rinse weight% 1. Stearyl trimethyl ammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Sisal 50% ethanol extract 3.0 6. Forsythia 50 % Ethyl acetate extract 3.0 7. Appropriate amount of pH adjuster 8. Appropriate amount of preservative 9. Residue to make purified water 100

(Formulation Example 7) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Sisal hot water extract 5.0 6. Agave 50% ethanol extract 5.0 7. Appropriate amount of preservatives 8. Residue with purified water 100

(Formulation Example 8) Hair tonic weight% 1. ethanol 40.0 2. ethyl oleate 1.0 3. polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: sisal 50% ethanol extract B: agave 50% ethanol Extract C: Forsythia 50% ethanol extract * Any one of A to C 10.0 5. Appropriate amount of fragrance and preservative 6. Purified water 100

(Formulation Example 9) Granule bath agent weight% 1. Sodium hydrogen carbonate 63.0 2. Anhydrous sodium sulfate 20.0 3. Borax 2.0 4. A: Dry powder of sisal 50% ethanol extract B: Agave 50% ethanol extract Dry powder of liquid C: Dry powder of 50% forsythia ethanol extract * Any one of A to C 15.0

(Formulation example 10) Coating protective agent 30% ethanol extract of sisal on gauze or liniment cloth
Impregnated with a prescription solution mixed with an appropriate amount of a forsythia 30% ethanol extract, antibiotics and anti-inflammatory, and attached to the wound site.
Alternatively, a 30% ethanol extract of sisal and a 30% ethanol extract of forsythia may be directly sprayed locally and covered with gauze or the like.

(Test 5) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. The use test was conducted with 10 panelists of 5 to 50 years old suffering from skin diseases such as dry skin, rough skin, eczema, and atopic dermatitis. This was done by applying to the face for 4 months. Also, for 10 people (5 to 50 years old) who have the same skin disease on the scalp and hairline, apply the appropriate amount of Hair Tonic of Formulation Example 8 to the scalp for 3 months after daily hair washing. The use test was carried out by.

The bath preparation of Formulation Example 9 was also applied to 10 people aged 3 to 65 years old who suffer from skin diseases such as dry skin, rough skin, eczema, and atopic dermatitis for 4 months. The test was conducted once a day by bathing in a bath water in which an appropriate amount of bath agent was dissolved. Controls include latex,
Those obtained by removing the various plant extracts of the present invention from hair tonic by the same method were used. As the bath preparation, those prepared by the same method except that anhydrous sodium sulfate was used instead of the dry powder of the various plant extracts of the present invention were used. The evaluation was performed according to the following criteria. The results are as shown in Table 2 and the numerical values in the table represent the number of persons. No one complained of abnormalities on the skin or scalp during the use period.

"Skin (scalp) disease improving effect" Efficacy: Redness, itching, dry skin, and rough skin due to inflammation such as eczema were improved. Somewhat effective: Redness and itching, dry skin, and rough skin due to inflammation such as eczema were slightly improved. Ineffective: No change from before use.

[0101]

[Table 2]

(Test Results) As shown in Table 2, the use of a cosmetic composition (emulsion, hair tonic, bath agent) containing the plant extracts of sisal, agave, and forsythia of the present invention resulted in inflammation and itching due to eczema. Good effect was confirmed on the improvement of skin and scalp inflammation such as dry skin and rough skin.

[0103]

EFFECTS OF THE INVENTION The extracts of sisal, agave, and forsythia of the present invention have an excellent histamine release inhibitory action, are also highly safe, and are therefore highly antiallergic.
Specifically, it can be used as a histamine release inhibitor, and is effective in preventing and treating various allergic diseases such as eczema, hives, atopic dermatitis, allergic rhinitis, and hay fever. Further, it can be applied to all forms of preparations (pharmaceuticals, quasi-drugs, cosmetics). In particular, the cosmetic composition (emulsion, hair tonic, bath preparation) of the present invention can be used for troubles such as allergic skin inflammatory diseases (for example, redness, eczema, edema, swelling, etc.), atopic dermatitis, rough skin, and dry skin. It can be used for the prevention and improvement of skin and scalp having In addition, it can be used and developed for oral compositions and foods.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/075 A61K 7/075 7/08 7/08 7/48 7/48 7/50 7/50 A61P 17/00 31/00 617 37/08 637E 43/00 643B // C11D 3/382 C11D 3/382 3/48 3/48 F term (reference) 4C083 AA082 AA111 AA112 AA122 AB272 AB312 AB352 AC022 AC072 AC102 AC122 AC182 AC242 AC352 AC392 AC432 AC442 AC532 AC542 AC642 AC782 AC812 AC902 AD042 AD112 AD512 CC01 CC03 CC05 CC07 CC23 CC25 CC32 CC33 CC38 CC39 DD12 DD16 DD23 DD31 EE13 EE42 4C088 AB64 AB85 AC01 AC04 AC05 AC06 AC11 AC13 BA08 BA09 BA10 CA06 MA07 MA07 MA07 MA07 MA37 MA41 MA43 MA63 ZA89 ZB13 ZC13 4H003 AB03 AB27 AB31 AB44 AC13 BA12 DA02 EB04 EB16 EB46 ED09 FA02 FA33

Claims (3)

[Claims] 1. An antiallergic agent comprising at least one plant extract selected from sisal, agave, and forsythia. 2. A histamine release inhibitor comprising at least one plant extract selected from sisal, agave, and forsythia. 3. The antiallergic agent according to claim 1 or 2,
A cosmetic composition comprising any one or more histamine release inhibitors.