JP2000169382A - Composition for preventing or treating allergy - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preventive or treating pharmaceutical composition, a preventive food and to provide a preventive method for allergy, especially atopic dermatitis, and to obtain a cosmetic composition having improving activity on rough skin. SOLUTION: A preventive or treating pharmaceutical composition and a preventive food for allergy, and a cosmetic composition having rough skin- improving activity each contains one or more kinds selected from the group consisting of Brassica oleracea var. italica, Brassica oleracea var. botrytis, Brassica oleracea var. acephala, Capsella bursa-pastoris, Raphanus sativus, Arabis grabra, Renunculus sceleratus, Chinese mustard, Cardamine regeliana, Barbarea vulgaris var. Stricta, Nasturtium officinale, Brassica juncea var. integlifolia Kitamura, Brassica juncea, Eutrema wasabi, Wasabia tenuis, Brassica campestis subsp. napus var. akana, Brassica sugukina, Brassica campestis subsp. rapa, Brassica campestis subsp. napus var. nippo-oleifera, Brassica oleracea var. capitata, Spinacia oleracea, Brassica repa var. pervidis, Apium greveslens var. dulce, Petresslium hortense, Lactuca sativa and Malus pumila var. dulcissima.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a pharmaceutical composition for preventing or treating allergy, a preventive food, a preventive method, or
The present invention relates to a cosmetic composition having a rough skin improving effect.

[0002]

2. Description of the Related Art In recent years, various allergies have become a problem, and there is a demand for inexpensive and highly safe pharmaceutical compositions and preventive foods for preventing or treating allergies.

[0003]

An object of the present invention is to provide a pharmaceutical composition for preventing or treating allergy, a preventive food, and the like as described above.

[0004]

Means for Solving the Problems As a result of intensive studies, the present inventors have found that broccoli, cabbage, spinach, komatsuna, takana, mustard, cauliflower, kale, celery,
The present inventors have found that vegetables and fruits such as parsley, lettuce, and apple have an effect of suppressing an increase in IgE that causes various allergies, particularly, atopic dermatitis, and completed the present invention.

That is, the present invention provides the inventions described in the following items. Item 1 broccoli, cauliflower, kale, nazuna,
Suzushiro, Hatao, Tashira, Taisei, Oba Nana, Yamagarashi, Oranagara, Takana, Japanese mustard, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oil A pharmaceutical composition for preventing or treating allergy, comprising one or more selected from the group consisting of cabbage, spinach, spinach, komatsuna, celery, parsley, lettuce and apple.

Item 2 Broccoli, cauliflower, kale, nazuna, suzushiro, scallop, squid, sacrifice, squid, squid, squid, squid, takana, mustard, wasabi, lily An allergy-preventive food containing one or more selected from the group consisting of wasabi, hinano, kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple.

Item 3 Broccoli, cauliflower, kale, nazuna, suzushiro, scallop, squid, sacrifice, squid, squid, squid, squid, takana, mustard, wasabi, lily An allergy-preventive food material containing one or more selected from the group consisting of wasabi, hinano, kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple.

Item 4 Broccoli, cauliflower, kale, nazuna, suzushiro, scallop, squid, sacrifice, squid, squid, squid, squid, takana, mustard, wasabi, lily A method for preventing allergies, comprising ingesting one or more selected from the group consisting of wasabi, hinano, kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple. .

Item 5: broccoli, cauliflower, kale, nazuna, suzushiro, scallop, squid, sacrifice, squid, squid, squid, squid, takana, mustard, wasabi, lily For the prevention or treatment of atopic dermatitis containing one or more selected from the group consisting of wasabi, hinano, kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple Pharmaceutical composition.

Item 6 Broccoli, Cauliflower, Kale, Nazuna, Suzushiro, Hatsuo, Taragarashi, Taisetsu, Obatake Nana, Yamagarashi, Oranagarasa, Takana, mustard, wasabi, lily A preventive food for atopic dermatitis containing one or more selected from the group consisting of wasabi, hinano, kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple.

Item 7: broccoli, cauliflower, kale, nazuna, suzushiro, scallop, squid, squid, squid, squid, squid, squid, takana, mustard, wasabi, lily A preventive food material for atopic dermatitis containing one or more selected from the group consisting of wasabi, hinano, kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple.

Item 8 Broccoli, Cauliflower, Kale, Nazuna, Suzushiro, Happa-o, Tara-shi, Taisei, Oba-tana-bana, Yamagarashi, Oranaga-ara, Takana, mustard, wasabi, lily Atopic skin characterized by ingesting one or more selected from the group consisting of wasabi, hinano, kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple Flame prevention method.

Item 9. Broccoli, cauliflower, kale, nazuna, sparrow, scallop, squid, sacrifice, squid, squid, squid, squid, takana, mustard, wasabi, lily Cosmetic composition having rough skin improving effect containing one or more selected from the group consisting of wasabi, hinano, kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple .

[0014]

DETAILED DESCRIPTION OF THE INVENTION 1. Allergy or atopic skin
Pharmaceutical composition for preventing or treating dermatitis The pharmaceutical composition for preventing or treating allergic or atopic dermatitis according to the present invention comprises broccoli, cauliflower, kale, nazuna, suzushiro, scallop, squid, swelling From Tsukebana, Yamagarashi, Oranagara, Takana, mustard, wasabi, lily wasabi, hinano, immediately kinako, turnip, oily, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple Contains one or more selected from the group consisting of:

[0015] These are vegetables or fruits, which have the effect of suppressing an increase in IgE.
For example, a prophylactic or therapeutic effect on atopic dermatitis, urticaria, bronchial asthma, allergic rhinitis, hay fever, allergic conjunctivitis, etc. can be expected. In particular, an effect of improving allergic skin symptoms accompanying an increase in IgE, for example, an effect of preventing or treating atopic dermatitis can be expected.

Among them, in the present invention, broccoli, cabbage, spinach, komatsuna, takana, mustard, kale, cauliflower, celery, parsley, lettuce and apple are preferred; especially broccoli, cabbage, takana, mustard It is preferable to use two or more kinds selected from the group consisting of cauliflower and kale.

Further, it is preferable to use a combination of two or more of broccoli, cabbage, spinach, komatsuna, celery, parsley, lettuce or apple, and specifically, any of broccoli and cabbage; broccoli, kale and cabbage 1 species and apple; broccoli,
It is preferable to use a combination of kale and cabbage with spinach; broccoli and kale; cabbage and kale.

In the present invention, when these vegetables are used, unless otherwise specified, portions used for food are usually used. For example, when the root portion is not edible, such as spinach, the root is not included.
Apples use their fruits.

In the present invention, raw vegetables or fruits may be crushed and used as it is, or only fruit juice after crushing or squeezing may be used. Further, the vegetable juice can be concentrated and used as a concentrate. Alternatively, the concentrate can be dried and processed into a powder, granule, tablet, or other form for use.

Therefore, in the present invention, washing, sorting,
Use those obtained by treating the above vegetables or fruits by conventional means appropriately combining various operations such as peeling, core removal, crushing, squeezing, filtration, separation, concentration, heating, cooling, homogenization, and drying. can do.

The pharmaceutical composition for prevention or treatment of the present invention contains the above-mentioned vegetables or fruits such as broccoli and cauliflower, and may contain only these vegetables or fruits. May be added.

When other components are added, the content of the above vegetables or fruits in the pharmaceutical composition for prevention or treatment of the present invention is not particularly limited as long as the desired effect can be achieved. It can be set appropriately according to etc.,
For example, based on the total weight of the composition, 0.001-99.
It can be about 99% by weight.

The addition amount of the other components is not limited, but may be, for example, 0.0% based on the total weight of the composition.
It can be about 01 to 99.99% by weight.

As other components, for example, vegetables or fruits other than the above-mentioned vegetables or fruits, for example, lemon, orange, carrot, radish, pumpkin, pepper, sweet potato, etc. are treated in the same manner as the above-mentioned vegetables or fruits. , Fruit juice, concentrate, granules and the like.

The amount of addition in this case is not particularly limited, but may be, for example, 0.001 to 99.
It is preferable to add 99% by weight.

Excipients, extenders, binders, wetting agents, disintegrants, surfactants, lubricants, dispersants, buffers, preservatives, dissolution aids commonly used in the preparation of pharmaceutical preparations Additives such as a preservative, a flavoring / flavoring agent, a stabilizer and the like can also be appropriately added as other components.

The amount of these additives commonly used in pharmaceuticals is not particularly limited as long as the desired effect is not hindered.
About 1 to 99.99% by weight can be added.

Various forms can be selected as the dosage unit form in the case of a pharmaceutical preparation depending on the purpose of treatment, and typical examples are tablets, pills, granules, capsules,
Solid preparations such as lozenges; powder preparations such as powders for internal use, powders for external use and powders; liquid preparations such as solutions, suspensions, emulsions, syrups, lotions, aerosols, infusions, and decoctions;
Creamy preparations such as ointments; cataplasms and the like.

The above pharmaceutical preparation can be prepared according to a conventional method in the above-mentioned form.

There are no particular restrictions on the method of administration of the above pharmaceutical preparations. Oral administration, transdermal administration, etc., depending on the form of the preparation, the age, sex and other conditions of the patient, the degree of the disease, etc.

The administration method is such that a liquid preparation such as an infusion or a decoction is dipped in a mask, coated, sprayed, etc., dried, and the mask is worn by a patient (particularly a hay fever patient). Is also included.

The dose of the above pharmaceutical preparation is appropriately selected depending on the form of the preparation, the age of the patient, gender and other conditions, the degree of the disease, and the like. As a fruit, 0. 1 adult per day.
The dose should be about 01 to 500 g, preferably about 0.1 to 150 g, more preferably about 7 to 30 g, and can be administered once or several times a day.

[0033] 2. Prevention of allergy or atopic dermatitis
Food or food material The allergic or atopic dermatitis preventive food or food material of the present invention is broccoli, cauliflower, kale, nazuna, suzushiro, scallop, squid, sacrifice, squid, squid, One or a member selected from the group consisting of aragarashi, takana, mustard, mustard, wasabi, lily wasabi, hinano, kinako, turnip, oil rape, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple Contains two or more.

The food or food material of the present invention may contain one or more of these vegetables or fruits, or may contain additives ordinarily used in foods or food materials.
It may contain other vegetables and the like.

In the food or food material of the present invention, preferred types and combinations of these vegetables or fruits, content in the composition when ingested as a composition, treatment method; types or combinations of other vegetables, etc. The amount of vegetables and the like to be added is the same as in the above-mentioned pharmaceutical composition for preventing or treating allergic or atopic dermatitis of the present invention.

As other components, additives that are usually used in the preparation of foods or food materials, such as excipients, sweeteners, thickeners, vitamins, and the like, as long as the desired effects are not hindered. Spices, coloring agents, fiber components, and the like can be appropriately selected and blended according to the food form.

The amount of the additives usually used in foods is not particularly limited and can be appropriately set according to the form of the foods. 0.0001 to 99.99% by weight.

The food of the present invention may be used, for example,
(Vegetables) Liquid foods such as juices, sauces, spreads and the like; solid foods such as granules, tablets, gum jelly, candy, chewing gum, bread, biscuits and the like can be prepared according to a conventional method.

On the other hand, the food material of the present invention can be used for preparing any food, and may be used, for example, for preparing food as described above.

Further, the food material of the present invention may be added to foods already prepared, for example, dried soups, powdered juices and the like, or may be added to and dissolved in canned juices. It may be such that it is ingested dispersedly.

The amount of the food or food material of the present invention to be taken can be appropriately determined according to the form of the food, the age, body weight, sex, purpose of ingestion and the like of the food, and is not particularly limited. The amount of the above vegetables or fruits is about 0.01 to 500 g per adult per day as raw vegetables or fruits,
Preferably about 0.1 to 150 g, more preferably 7 to 150 g
An amount of about 30 g can be taken once a day or divided into 2 to 4 times.

[0042] 3. Prevention of allergy or atopic dermatitis
Method of the present invention for preventing allergy or atopic dermatitis,
A method characterized by ingesting vegetables or fruits as described above.

The types, preferred types, preferred combinations, contents in the composition when ingested as a composition, treatment methods and the like of the vegetables or fruits to be ingested in the method of the present invention are described in the allergic or atopic dermatitis of the present invention. It is the same as the pharmaceutical composition for prevention or treatment.

In the method of the present invention, it can be taken together with other vegetables, additives and the like. The type or combination, amount of addition, dosage form and form, etc. of the pharmaceutical composition for prevention or treatment of the present invention, Or it is the same as that of the food of the present invention.

The amount of intake, the number of times of intake, and the like can be the same as those of the food of the present invention. 4. Cosmetic composition having skin roughness improving action The cosmetic composition of the present invention has an action of improving the skin quality of rough skin due to various causes (for example, allergy such as atopic dermatitis).

The cosmetic composition of the present invention having a skin roughening improving effect includes broccoli, cauliflower, kale, nazuna, suzushiro, scallop, sashimi, sashimi, sashimi, sashimi, sashimi. One or two or more species selected from the group consisting of radish, takana, mustard, wasabi, lily wasabi, hinano, kinako, turnip, oily rape, cabbage, spinach, komatsuna, celery, parsley, lettuce and apple It contains.

The cosmetic composition of the present invention may contain only one or more of these vegetables or fruits, or may contain other vegetables and the like.

[0048] In the cosmetic composition of the present invention, a preferred kind or a preferred combination of these vegetables or fruits,
The content and treatment method; the type or combination of other vegetables; and the amount of other vegetables added are the same as in the pharmaceutical composition for preventing or treating allergy of the present invention.

As the form of the cosmetic, various forms can be selected according to the purpose. Specifically, soap, face wash, lotion, milky lotion, foundation, lipstick, lip balm,
Cleansing cream, massage cream, pack,
Hand cream, hand powder, body shampoo,
Body lotions, body creams, bath cosmetics and the like can be mentioned.

The cosmetic composition of the present invention can be prepared according to a conventional method using the above-mentioned vegetables or fruits together with a suitable carrier according to the form.

The carrier used in the cosmetic composition of the present invention can be appropriately selected from carriers generally used depending on the form of the cosmetic, and examples thereof include a binder, a surfactant,
Examples include diluents or excipients such as humectants, fillers, extenders, wetting agents and the like.

Further, the cosmetic composition of the present invention may contain, if necessary, a preservative, a coloring agent, a preservative, an antioxidant, a fragrance and the like.

The cosmetic composition of the present invention can be used according to the usual usage in each form.

The application amount of the cosmetic composition of the present invention is appropriately selected depending on the form, the degree of rough skin and the like, and is not particularly limited. For example, the raw weight of the above-mentioned vegetables or fruits is 0.01%. The amount of about 10 to 10 g can be applied once a day or divided into 2 to 4 times.

[0055]

EFFECTS OF THE INVENTION Vegetables or fruits such as broccoli may cause various allergies, especially Ig which causes atopic dermatitis.
It can suppress an increase in E antibodies, and can be expected to have an effect of preventing or treating allergy.

Therefore, the food or food material containing these vegetables or fruits can be ingested as a functional food for the purpose of preventing allergies, a food for specified health use, a food for the sick, and the like.

Further, since vegetables or fruits, which have been used for a long time, are used, they can be used for a long time without worry for prevention or treatment.

[0058]

The present invention will be described in more detail with reference to the following examples.

Example 1 Ten 4-week-old male NC / Nga mice were purchased from Japan SLC, Inc., and the room temperature was 23 ± 3 ° C. and the humidity was 55 ±.
15%, light-dark cycle 12 hours (light period 7:00 to 19:
(00). The mice were assumed to be housed in 5 cages, preliminarily reared for 7 days on a standard diet (Lab MR Stock, Nippon Agricultural Industry Co., Ltd.), and then subjected to the following test in groups of 5 mice.

The food was freely consumed. In the group of Examples, crushed mixture of broccoli and cabbage (broccoli: 44% by weight, based on MF powder (Oriental Yeast Co., Ltd.)
0.144% by weight of freeze-dried product of cabbage (56% by weight)
After the addition, a mixture obtained by a mixer was provided. The control group was provided with MF powder to which 0.144% by weight of α corn starch (Oriental Yeast Co., Ltd.) was added.

[0061] Serum IgE levels were collected from the cave blood, and mouse IgE
The measurement was performed using a kit “Yamasa” EIA (Lot. 702). The results are shown in FIG.

As is apparent from FIG. 1, the increase in the IgE value was suppressed in the example group as compared with the control group.

Hereinafter, formulation examples and formulation examples of the food of the present invention will be described. In addition, below, "%" represents all weight%.

Formulation Example 1 Tablet Lactose 75.0% Gelatin 10.0% Broccoli freeze-dried material 1.5% Cabbage freeze-dried material 1.0% Fruit flavor 0.5% Water 12.0%

Formulation Example 2 gum jelly gum arabic 18.0% galacto-oligosaccharide 23.0% concentrated broccoli juice 18.0% starch syrup 23.0% flavor 0.5% pigment 0.05% water 17.45%.

Formulation Example 3 Juice Apple juice 15.0% Broccoli puree 20.0% Cabbage juice 5.0% Concentrated lemon juice 0.5% Pigment 0.05% Flavor 0.5% Water 58.95%

Formulation Example 4 Granules Lactose 90.0% Talc 0.5% Cabbage freeze-dried product 5.0% Fruit flavor 0.5% Water 4.0%

Formulation Example 5 Capsules Broccoli freeze-dried product 60.0% Gelatin 5.0% Glycerin 35.0%.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a graph showing the time course of mouse serum IgE.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A23L 1/30 A23L 1/30 B 4C083 A61K 7/00 A61K 7/00 K 4C088 W 7/48 7/48 A61P 17 / 00 31/00 617 37/08 637E // A23G 3/00 101 A23G 3/00 101 A23L 1/06 A23L 1/06 2/02 2/02 ZF term (reference) 4B014 GB06 GB07 GB11 GB13 GG09 GK12 4B016 LC07 LE01 LE05 LG01 LG10 LP01 LP02 LP08 4B017 LC03 LE01 LG04 LG06 LG07 LP01 LP03 4B018 LB01 LB03 LB08 LE01 LE05 MD52 MD53 ME07 MF01 MF06 MF07 4B041 LC10 LD02 LK27 LK29 4C083 AA111 AA112 AB432 AC122 AD212 AD03 DD14 DD12 DDBB DD412 DD412 DD412 DD412 DD412 DD412 AB15 AB26 AB32 AB40 AB51 AC04 AC05 BA06 BA07 BA08 MA07 MA52 NA14 ZA33 ZA34 ZA59 ZA89 ZB11 ZB13

Claims (9)

[Claims] Claims 1. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
A pharmaceutical composition for preventing or treating allergy comprising one or more selected from the group consisting of celery, parsley, lettuce and apple. 2. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
An allergy preventive food containing one or more selected from the group consisting of celery, parsley, lettuce and apple. 3. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
An allergy-preventive food material containing one or more selected from the group consisting of celery, parsley, lettuce and apple. 4. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
A method for preventing allergy comprising ingesting one or more selected from the group consisting of celery, parsley, lettuce and apple. 5. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
A pharmaceutical composition for preventing or treating atopic dermatitis, comprising one or more selected from the group consisting of celery, parsley, lettuce and apple. 6. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
A preventive food for atopic dermatitis comprising one or more selected from the group consisting of celery, parsley, lettuce and apple. 7. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
A food material for preventing atopic dermatitis comprising one or more selected from the group consisting of celery, parsley, lettuce and apple. 8. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
A method for preventing atopic dermatitis, comprising ingesting one or more selected from the group consisting of celery, parsley, lettuce and apple. 9. Broccoli, cauliflower, kale,
Nazuna, Suzushiro, Hanao, Tegara, Treasure, Oba Natsubana, Yamagarashi, Oranagara, Takana, Karashina, Wasabi, Yuriwasabi, Hinano, Immediately, Turnip, Oily, cabbage, spinach, komatsuna,
A cosmetic composition having one or more selected from the group consisting of celery, parsley, lettuce and apple and having a skin roughness improving effect.