IT1234961B - Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi. - Google Patents

Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi.

Info

Publication number: IT1234961B
Authority: IT; Italy
Prior art keywords: polypeptides; activities; sequences; nucleic acids; growth factors
Prior art date: 1988-03-24

Application number

IT8919917A

Other languages

English (en)

Other versions

IT8919917A0 (it

Inventor

Joseph P Brown

Daniel R Twardzik

Hans Marquardt

George J Todaro

A Gregory Bruce

Timothy M Rose

Anthony F Purchio

Shiu Lok Hu

Wen Chang

Suo Win Liu

Original Assignee

Oncogen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-24

Filing date

1989-03-24

Publication date

1992-06-09

1989-03-24 Application filed by Oncogen filed Critical Oncogen

1989-03-24 Publication of IT8919917A0 publication Critical patent/IT8919917A0/it

1992-06-09 Application granted granted Critical

1992-06-09 Publication of IT1234961B publication Critical patent/IT1234961B/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Plant Pathology (AREA)
Hematology (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Endocrinology (AREA)
Dermatology (AREA)

IT8919917A 1988-03-24 1989-03-24 Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi. IT1234961B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17265388A	1988-03-24	1988-03-24

Publications (2)

Publication Number	Publication Date
IT8919917A0 IT8919917A0 (it)	1989-03-24
IT1234961B true IT1234961B (it)	1992-06-09

Family

ID=22628611

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8919917A IT1234961B (it)	1988-03-24	1989-03-24	Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi.

Country Status (22)

Country	Link
JP (1)	JPH0279981A (it)
KR (1)	KR890014743A (it)
AU (2)	AU3169589A (it)
BE (1)	BE1004202A5 (it)
CH (1)	CH681081A5 (it)
DE (1)	DE3910084A1 (it)
DK (1)	DK146789A (it)
ES (1)	ES2013408A6 (it)
FI (1)	FI891308A (it)
FR (1)	FR2632321A1 (it)
GB (1)	GB2219799B (it)
GR (1)	GR1000876B (it)
HU (1)	HUT50501A (it)
IE (1)	IE890950L (it)
IL (1)	IL89673A0 (it)
IT (1)	IT1234961B (it)
LU (1)	LU87489A1 (it)
NL (1)	NL8900724A (it)
NO (1)	NO891273D0 (it)
NZ (1)	NZ228427A (it)
PT (1)	PT90118B (it)
SE (1)	SE8901031L (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU626524B2 (en) *	1987-05-29	1992-08-06	Bristol-Myers Squibb Company	Cloning and expression of simian transforming growth factor- beta 1
CA2037440A1 (en) *	1990-03-02	1991-09-03	Gregory D. Plowman	Her3: a novel egf receptor homolog
EP0739984A1 (en) *	1995-04-26	1996-10-30	San Tumorforschungs-Gmbh	Bivalent polypeptides containing at least two domains
CA2249213A1 (en) *	1996-04-10	1997-10-16	Human Genome Sciences, Inc.	Extracellular/epidermal growth factor-like protein
US6852506B1 (en)	1996-04-10	2005-02-08	Human Genome Sciences, Inc.	Extracellular/epidermal growth factor-like protein

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1983004030A1 (en) *	1982-05-06	1983-11-24	Applied Molecular Genetics, Inc.	The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
JPS6028994A (ja) *	1983-07-08	1985-02-14	Wakunaga Seiyaku Kk	〔２１―ロイシン〕ヒトウロガストロン
WO1985002198A1 (en) *	1983-11-01	1985-05-23	Amgen	Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
JP2554459B2 (ja) *	1984-07-02	1996-11-13	アース製薬株式会社	β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体
EP0199769A4 (en) *	1984-10-30	1989-11-29	Oncogen	NEW POLYPEPTIDES WITH GROWTH FACTOR EFFECT AND THESE ENCODING NUCLEIC ACID SEQUENCES.
GB8507666D0 (en) *	1985-03-25	1985-05-01	Wellcome Found	Epidermal growth factor production
US4743679A (en) *	1986-02-24	1988-05-10	Creative Biomolecules, Inc.	Process for producing human epidermal growth factor and analogs thereof
GB2210618B (en) *	1987-10-08	1991-10-16	British Bio Technology	Synthetic egf gene
ES2081801T3 (es) *	1987-10-30	1996-03-16	Bristol Myers Squibb Co	Plasmidos de expresion.
JP2970811B2 (ja) *	1987-10-30	1999-11-02	オンコゲンアリミテッドパートナーシップ	原核生物細胞中にポリペプチドを調製するための発現システム

1989
- 1989-03-20 IL IL89673A patent/IL89673A0/xx unknown
- 1989-03-20 FI FI891308A patent/FI891308A/fi not_active IP Right Cessation
- 1989-03-21 NZ NZ228427A patent/NZ228427A/xx unknown
- 1989-03-22 NO NO891273A patent/NO891273D0/no unknown
- 1989-03-22 DK DK146789A patent/DK146789A/da not_active Application Discontinuation
- 1989-03-22 SE SE8901031A patent/SE8901031L/xx not_active Application Discontinuation
- 1989-03-22 ES ES8901049A patent/ES2013408A6/es not_active Expired - Lifetime
- 1989-03-23 NL NL8900724A patent/NL8900724A/nl not_active Application Discontinuation
- 1989-03-23 AU AU31695/89A patent/AU3169589A/en not_active Abandoned
- 1989-03-23 GR GR890100185A patent/GR1000876B/el unknown
- 1989-03-23 IE IE890950A patent/IE890950L/xx unknown
- 1989-03-23 GB GB8906758A patent/GB2219799B/en not_active Expired - Fee Related
- 1989-03-24 JP JP1073723A patent/JPH0279981A/ja active Pending
- 1989-03-24 BE BE8900329A patent/BE1004202A5/fr not_active IP Right Cessation
- 1989-03-24 IT IT8919917A patent/IT1234961B/it active
- 1989-03-24 HU HU891515A patent/HUT50501A/hu unknown
- 1989-03-24 KR KR1019890003761A patent/KR890014743A/ko not_active Application Discontinuation
- 1989-03-24 FR FR8903952A patent/FR2632321A1/fr not_active Withdrawn
- 1989-03-24 LU LU87489A patent/LU87489A1/xx unknown
- 1989-03-27 PT PT90118A patent/PT90118B/pt active IP Right Grant
- 1989-03-28 DE DE3910084A patent/DE3910084A1/de not_active Withdrawn
- 1989-03-28 CH CH1114/89A patent/CH681081A5/de not_active IP Right Cessation
1992
- 1992-12-04 AU AU29904/92A patent/AU2990492A/en not_active Abandoned

Also Published As

Publication number	Publication date
IT8919917A0 (it)	1989-03-24
IL89673A0 (en)	1989-09-28
FI891308A (fi)	1989-09-25
DE3910084A1 (de)	1989-11-16
GB8906758D0 (en)	1989-05-10
DK146789A (da)	1989-09-25
GB2219799A (en)	1989-12-20
GB2219799B (en)	1992-10-14
NO891273D0 (no)	1989-03-22
AU2990492A (en)	1993-03-04
CH681081A5 (it)	1993-01-15
ES2013408A6 (es)	1990-05-01
PT90118B (pt)	1994-07-29
PT90118A (pt)	1989-11-10
NL8900724A (nl)	1989-10-16
HUT50501A (en)	1990-02-28
FR2632321A1 (fr)	1989-12-08
GR1000876B (el)	1993-03-16
SE8901031D0 (sv)	1989-03-22
LU87489A1 (fr)	1989-10-26
JPH0279981A (ja)	1990-03-20
DK146789D0 (da)	1989-03-22
KR890014743A (ko)	1989-10-25
IE890950L (en)	1989-09-24
BE1004202A5 (fr)	1992-10-13
FI891308A0 (fi)	1989-03-20
NZ228427A (en)	1993-03-26
SE8901031L (sv)	1989-09-25
AU3169589A (en)	1989-09-28
GR890100185A (en)	1990-01-19

Publication	Publication Date	Title
IT8523408A0 (it)	1985-12-30	Procedimento per la identificazione di acidi nucleici.
DE69132905D1 (de)	2002-02-21	Detektion von Nukleinsäuresequenzen
DK216589A (da)	1989-07-04	Dna sekvenser, rekombinante dna molekyler samt fremgangsmaader til fresmtilling af oploeselige t4-proteiner
DE69131935D1 (de)	2000-03-02	Bestimmung von DNS-Sequenzen
DE69333346D1 (de)	2004-01-22	Neuartiges p- selectin ligandenprotein
IT8720786A0 (it)	1987-06-04	Acidi bifenil-idrossamici.
DE3855449D1 (de)	1996-09-05	DNS-Klone von menschlichem Thrombomodulin
IT1238374B (it)	1993-07-16	Recupero di acidi umici.
ITRM910286A1 (it)	1992-10-29	Procedimento per rivelare sequenze di acidi nucleici e kit per la sua utilizzazione.
IT1234961B (it)	1992-06-09	Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi.
IL98273A0 (en)	1992-06-21	Dna sequences,proteins having esterase activity coded by them,and use of such proteins
DE68910771D1 (de)	1993-12-23	Verfahren zur Herstellung von verbessertem Proteinhydrolysat.
NO905561D0 (no)	1990-12-21	Proteiner og nukleinsyrer.
DE3765784D1 (de)	1990-12-06	Zusammensetzung von aminosaeuren.
RU97103147A (ru)	1999-05-27	Днк-последовательности, кодирующие человеческие протеины тх и ту, родственные конвергирующему интерлейкин-1-бета ферменту
ZA916431B (en)	1992-05-27	Nucleotide and amino acid sequences of protein mtp 40 of m.tuberculosis and synthetic peptides derived therefrom
DE69003306D1 (de)	1993-10-21	Reinigung von Proteinhydrolysaten.
AU6655190A (en)	1991-01-24	Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides
IT8720291A0 (it)	1987-04-28	Sintesi di alfa amminoacidi otticamente attivi.
IT1240228B (it)	1993-11-27	Preparazione di acidi alfa-metilarenacetici.
IT8848169A0 (it)	1988-07-11	Procedimento per la preparazione di polilattoni di acidi poli [a-idrossi-(acrilici e/o-crotonici)]
IE882244L (en)	1989-01-24	Dna sequences encoding proteins having the biological¹properties of cystatin c
NO891274L (no)	1989-09-25	Nye polypeptider med vekstfaktoraktivitet og nukleinsyresekvenser som koder for disse.
SE8803443D0 (sv)	1988-09-28	Fusion protein possessing enzymatic activity and a nucleotide sequence coding for such fusion protein
ITTO930717A1 (it)	1995-03-30	Metodo per estrarre acidi nucleici e metodo per rivelare sequenze specificate di acidi nucleici.