IT1284604B1 - Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva - Google Patents
Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attivaInfo
- Publication number
- IT1284604B1 IT1284604B1 IT96MI001983A ITMI961983A IT1284604B1 IT 1284604 B1 IT1284604 B1 IT 1284604B1 IT 96MI001983 A IT96MI001983 A IT 96MI001983A IT MI961983 A ITMI961983 A IT MI961983A IT 1284604 B1 IT1284604 B1 IT 1284604B1
- Authority
- IT
- Italy
- Prior art keywords
- controlled release
- oral administration
- pharmaceutical compositions
- release pharmaceutical
- active substance
- Prior art date
Links
- 238000013270 controlled release Methods 0.000 title abstract 3
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001597 nifedipine Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 title 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001983A IT1284604B1 (it) | 1996-09-27 | 1996-09-27 | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva |
ZA9708099A ZA978099B (en) | 1996-09-27 | 1997-09-09 | Controlled release pharmaceutical compositions for the oral administration containing nifedipine as active substance. |
US08/925,966 US5871775A (en) | 1996-09-27 | 1997-09-09 | Controlled release pharmaceutical compositions for the oral administration containing nifedipine as active substance |
AU37567/97A AU719075B2 (en) | 1996-09-27 | 1997-09-12 | Controlled release pharmaceutical compositions for the oral administration containing nifedipine as active substance |
EP97116153A EP0838218B1 (en) | 1996-09-27 | 1997-09-17 | Controlled release pharmaceutical compositions for the oral administration containing nifedipine as active substance |
ES97116153T ES2202528T3 (es) | 1996-09-27 | 1997-09-17 | Composiciones farmaceuticas de liberacion controlada para la administracion oral que contienen nifedipina como principio activo. |
AT97116153T ATE243499T1 (de) | 1996-09-27 | 1997-09-17 | Pharmazeutische zusammensetzungen mit kontrollierter freisetzung zur oralen verabreichung enthaltend nifedipin als wirkstoff |
DE69723024T DE69723024T2 (de) | 1996-09-27 | 1997-09-17 | Pharmazeutische Zusammensetzungen mit kontrollierter Freisetzung zur oralen Verabreichung enthaltend Nifedipin als Wirkstoff |
NZ328783A NZ328783A (en) | 1996-09-27 | 1997-09-18 | Sustained release composition containing nifedipine and polyvinyl pyrrolidine |
CA002216277A CA2216277C (en) | 1996-09-27 | 1997-09-22 | Controlled release pharmaceutical compositions for the oral administration containing nifedipine as active substance |
CN97119609A CN1110304C (zh) | 1996-09-27 | 1997-09-26 | 用于口服的含有活性成份硝苯吡啶的缓释药物组合物 |
BR9706214A BR9706214A (pt) | 1996-09-27 | 1997-09-26 | Composições farmacêuticas de liberação controlada para administração oral contendo nifedipina como substância ativa e processo para a preparação de composiç es farmacêuticas para a administração oral contendo nifedipina como substância ativa |
JP9263279A JPH10152440A (ja) | 1996-09-27 | 1997-09-29 | 活性物質としてニフェジピンを含有する経口投与用調節放出医薬組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001983A IT1284604B1 (it) | 1996-09-27 | 1996-09-27 | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI961983A1 ITMI961983A1 (it) | 1998-03-27 |
IT1284604B1 true IT1284604B1 (it) | 1998-05-21 |
Family
ID=11374935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT96MI001983A IT1284604B1 (it) | 1996-09-27 | 1996-09-27 | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva |
Country Status (13)
Country | Link |
---|---|
US (1) | US5871775A (it) |
EP (1) | EP0838218B1 (it) |
JP (1) | JPH10152440A (it) |
CN (1) | CN1110304C (it) |
AT (1) | ATE243499T1 (it) |
AU (1) | AU719075B2 (it) |
BR (1) | BR9706214A (it) |
CA (1) | CA2216277C (it) |
DE (1) | DE69723024T2 (it) |
ES (1) | ES2202528T3 (it) |
IT (1) | IT1284604B1 (it) |
NZ (1) | NZ328783A (it) |
ZA (1) | ZA978099B (it) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040115134A1 (en) * | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
US20040219210A1 (en) * | 2003-05-01 | 2004-11-04 | Jian-Hwa Guo | Controlled release solid dosage nifedipine formulations |
WO2006066932A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Stable pharmaceutical composition comprising an active substance in the form of solid solution |
CN101272848B (zh) * | 2005-07-28 | 2013-03-13 | Isp投资有限公司 | 改进喷雾干燥的粉末和颗粒材料性质的方法,以及由此生产的产品 |
US20070178152A1 (en) * | 2005-11-04 | 2007-08-02 | Shelton Michael C | Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents |
US20080085315A1 (en) * | 2006-10-10 | 2008-04-10 | John Alfred Doney | Amorphous ezetimibe and the production thereof |
WO2008076780A2 (en) * | 2006-12-14 | 2008-06-26 | Isp Investments Inc. | Amorphous valsartan and the production thereof |
US8613946B2 (en) * | 2006-12-21 | 2013-12-24 | Isp Investment Inc. | Carotenoids of enhanced bioavailability |
WO2008092046A2 (en) * | 2007-01-26 | 2008-07-31 | Isp Investments Inc. | Amorphous oxcarbazepine and the production thereof |
CN101622302B (zh) * | 2007-01-26 | 2013-01-23 | Isp投资公司 | 生产喷雾干燥产品的制剂工艺方法 |
DE102007048705A1 (de) | 2007-10-11 | 2009-04-16 | Bayer Healthcare Ag | Amorphe Formulierung |
WO2014016842A1 (en) * | 2012-07-23 | 2014-01-30 | Symed Labs Limited | Amorphous coprecipitates of rivaroxaban |
US9700549B2 (en) | 2013-10-03 | 2017-07-11 | David Wise | Compositions and methods for treating pelvic pain and other conditions |
CN109730967B (zh) * | 2019-02-19 | 2021-08-03 | 广东工业大学 | 一种硝苯地平固体分散体及其制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3033919A1 (de) * | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung |
DE3270785D1 (en) * | 1981-10-29 | 1986-05-28 | Bayer Ag | Process for preparing solid fast-releasing drug formulations of dihydropyridines |
DE3376198D1 (en) * | 1983-11-30 | 1988-05-11 | Siegfried Ag | Therapeutic coronary composition in the form of soft gelatine capsules |
JPS6136213A (ja) * | 1984-07-27 | 1986-02-20 | Rooto Seiyaku Kk | 口腔用組成物 |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
IT1187751B (it) * | 1985-10-15 | 1987-12-23 | Eurand Spa | Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute |
DE3738236A1 (de) * | 1987-11-11 | 1989-05-24 | Euro Celtique Sa | Beisskapsel |
GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
US5209933A (en) * | 1990-01-10 | 1993-05-11 | Syntex (U.S.A.) Inc. | Long acting calcium channel blocker composition |
GB9200607D0 (en) * | 1992-01-13 | 1992-03-11 | Ethical Pharma Ltd | Pharmaceutical compositions containing nifedipine and process for the preparation thereof |
CN1120435A (zh) * | 1994-01-04 | 1996-04-17 | 贵州泰康中医保健技术有限公司 | 硝苯吡啶缓释胶囊 |
CN1129103A (zh) * | 1995-02-14 | 1996-08-21 | 永信药品工业股份有限公司 | 硝苯吡啶剂型的开发 |
DE19515972A1 (de) * | 1995-05-02 | 1996-11-07 | Bayer Ag | Arzneizubereitungen mit kontrollierter Freisetzung und Verfahren zu ihrer Herstellung |
SI9500173B (sl) * | 1995-05-19 | 2002-02-28 | Lek, | Trofazna farmacevtska oblika s konstantnim in kontroliranim sproščanjem amorfne učinkovine za enkrat dnevno aplikacijo |
-
1996
- 1996-09-27 IT IT96MI001983A patent/IT1284604B1/it active IP Right Grant
-
1997
- 1997-09-09 ZA ZA9708099A patent/ZA978099B/xx unknown
- 1997-09-09 US US08/925,966 patent/US5871775A/en not_active Expired - Fee Related
- 1997-09-12 AU AU37567/97A patent/AU719075B2/en not_active Ceased
- 1997-09-17 EP EP97116153A patent/EP0838218B1/en not_active Expired - Lifetime
- 1997-09-17 ES ES97116153T patent/ES2202528T3/es not_active Expired - Lifetime
- 1997-09-17 AT AT97116153T patent/ATE243499T1/de not_active IP Right Cessation
- 1997-09-17 DE DE69723024T patent/DE69723024T2/de not_active Expired - Fee Related
- 1997-09-18 NZ NZ328783A patent/NZ328783A/en unknown
- 1997-09-22 CA CA002216277A patent/CA2216277C/en not_active Expired - Fee Related
- 1997-09-26 CN CN97119609A patent/CN1110304C/zh not_active Expired - Fee Related
- 1997-09-26 BR BR9706214A patent/BR9706214A/pt active Search and Examination
- 1997-09-29 JP JP9263279A patent/JPH10152440A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2202528T3 (es) | 2004-04-01 |
CA2216277C (en) | 2003-06-10 |
US5871775A (en) | 1999-02-16 |
AU3756797A (en) | 1998-04-02 |
ITMI961983A1 (it) | 1998-03-27 |
ZA978099B (en) | 1998-03-27 |
BR9706214A (pt) | 1999-05-04 |
EP0838218B1 (en) | 2003-06-25 |
JPH10152440A (ja) | 1998-06-09 |
CA2216277A1 (en) | 1998-03-27 |
EP0838218A1 (en) | 1998-04-29 |
CN1183960A (zh) | 1998-06-10 |
DE69723024D1 (de) | 2003-07-31 |
CN1110304C (zh) | 2003-06-04 |
NZ328783A (en) | 1998-02-26 |
DE69723024T2 (de) | 2004-04-29 |
AU719075B2 (en) | 2000-05-04 |
ATE243499T1 (de) | 2003-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |