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IL153395A0 - Vitamin d derivatives - Google Patents

Vitamin d derivatives

Info

Publication number
IL153395A0
IL153395A0 IL15339501A IL15339501A IL153395A0 IL 153395 A0 IL153395 A0 IL 153395A0 IL 15339501 A IL15339501 A IL 15339501A IL 15339501 A IL15339501 A IL 15339501A IL 153395 A0 IL153395 A0 IL 153395A0
Authority
IL
Israel
Prior art keywords
hydrogen atom
vitamin
derivatives
represent
atom
Prior art date
Application number
IL15339501A
Other languages
English (en)
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of IL153395A0 publication Critical patent/IL153395A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5929,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL15339501A 2000-06-15 2001-06-14 Vitamin d derivatives IL153395A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2000179251 2000-06-15
JP2000351412 2000-11-17
JP2000375024 2000-12-08
PCT/JP2001/005062 WO2001096293A1 (fr) 2000-06-15 2001-06-14 Derives de vitamine d

Publications (1)

Publication Number Publication Date
IL153395A0 true IL153395A0 (en) 2003-07-06

Family

ID=27343730

Family Applications (3)

Application Number Title Priority Date Filing Date
IL15339501A IL153395A0 (en) 2000-06-15 2001-06-14 Vitamin d derivatives
IL153395A IL153395A (en) 2000-06-15 2002-12-11 History of Vitamin D
IL178350A IL178350A (en) 2000-06-15 2006-09-27 Vitamin d derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL153395A IL153395A (en) 2000-06-15 2002-12-11 History of Vitamin D
IL178350A IL178350A (en) 2000-06-15 2006-09-27 Vitamin d derivatives

Country Status (15)

Country Link
US (1) US7985744B2 (ko)
EP (1) EP1295871B1 (ko)
JP (2) JP3706104B2 (ko)
KR (2) KR100734799B1 (ko)
CN (2) CN100469764C (ko)
AT (1) ATE509910T1 (ko)
AU (2) AU2001264280B2 (ko)
CA (2) CA2411409C (ko)
DK (1) DK1295871T3 (ko)
HK (2) HK1054373B (ko)
IL (3) IL153395A0 (ko)
NO (2) NO328868B1 (ko)
NZ (1) NZ528622A (ko)
TW (1) TWI288131B (ko)
WO (1) WO2001096293A1 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
CA2414407A1 (en) * 2000-07-18 2002-01-24 Bone Care International, Inc. Stabilized 1.alpha.-hydroxy vitamin d
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
KR20130119514A (ko) * 2004-12-03 2013-10-31 니뽄 신야쿠 가부시키가이샤 9,10-세코프레그난 유도체 및 의약
WO2006093291A1 (ja) * 2005-03-04 2006-09-08 Tokyo Medical And Dental University 19-ノルビタミンd誘導体
ES2406947T3 (es) * 2005-11-30 2013-06-10 Chugai Seiyaku Kabushiki Kaisha Método para producir derivado de vitamina D utilizando fotorreacción
WO2007064011A1 (ja) 2005-12-02 2007-06-07 Chugai Seiyaku Kabushiki Kaisha コンバージェント法を用いるビタミンd誘導体の製造方法
US8796246B2 (en) * 2006-06-02 2014-08-05 Nippon Shinyaku Co., Ltd. 9, 10-secopregnane derivative and pharmaceutical
US9481646B2 (en) * 2007-04-18 2016-11-01 The Johns Hopkins University Low calcemic, highly antiproliferative, analogs of calcitriol
US8551463B2 (en) 2007-10-22 2013-10-08 Living Proof, Inc. Hair care compositions and methods of treating hair
DE102009028939A1 (de) * 2009-08-27 2011-03-03 Ludwig-Maximilians-Universität München Verfahren zur Herstellung von Arylaluminiumhalogeniden und deren Verwendung
JP5652723B2 (ja) * 2012-08-17 2015-01-14 フォーモサ・ラボラトリーズ・インコーポレーテッド マキサカルシトールの新しい結晶形態
CN106279239B (zh) * 2015-05-29 2019-06-28 上海彩迩文生化科技有限公司 多烯化合物、制备方法及其应用
US10548908B2 (en) 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
CN113105517B (zh) * 2021-04-10 2022-03-01 台州仙琚药业有限公司 雄甾-1,4,9-三烯-3,17-二酮的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
RU2139276C1 (ru) * 1991-11-07 1999-10-10 Рисерч Инститьют фор Медсин энд Кемистри Производные амида витамина d и фармацевтическая композиция
JP3493037B2 (ja) * 1991-12-18 2004-02-03 中外製薬株式会社 22−オキサコレカルシフェロール誘導体とその製造方法
GB9226877D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
GB9309422D0 (en) * 1993-05-07 1993-06-23 Res Inst Medicine Chem Chemical compounds
US5361722A (en) 1993-06-16 1994-11-08 Universal Dairy Equipment Inc. Milking facility with service alley
ATE195513T1 (de) 1994-04-11 2000-09-15 Chugai Pharmaceutical Co Ltd 22-thiavitamin-d3-derivate
JP3759639B2 (ja) 1994-04-11 2006-03-29 中外製薬株式会社 22−チアビタミン▲d3▼誘導体
PE28297A1 (es) * 1995-01-26 1997-08-20 Hoffmann La Roche Empleo dermatologico de derivados de vitamina d
US6184398B1 (en) 1996-12-20 2001-02-06 Chugai Seiyaku Kabushiki Kaisha 16-ene-vitamin D derivatives
ATE248814T1 (de) * 1996-12-20 2003-09-15 Chugai Pharmaceutical Co Ltd 16-ene-vitamin d derivate
JP4012293B2 (ja) 1996-12-20 2007-11-21 中外製薬株式会社 16−エン−ビタミンd誘導体
AU743514B2 (en) * 1997-05-16 2002-01-24 Women & Infants Hospital Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof
JP4803939B2 (ja) * 2000-04-19 2011-10-26 中外製薬株式会社 ビタミンd誘導体
ES2406947T3 (es) * 2005-11-30 2013-06-10 Chugai Seiyaku Kabushiki Kaisha Método para producir derivado de vitamina D utilizando fotorreacción
WO2007064011A1 (ja) * 2005-12-02 2007-06-07 Chugai Seiyaku Kabushiki Kaisha コンバージェント法を用いるビタミンd誘導体の製造方法

Also Published As

Publication number Publication date
JP3706104B2 (ja) 2005-10-12
CN100469764C (zh) 2009-03-18
CA2411409A1 (en) 2002-12-04
AU2001264280C1 (en) 2001-12-24
JP4233504B2 (ja) 2009-03-04
WO2001096293A1 (fr) 2001-12-20
NO20026014D0 (no) 2002-12-13
US20040019023A1 (en) 2004-01-29
AU6428001A (en) 2001-12-24
TWI288131B (en) 2007-10-11
NO332310B1 (no) 2012-08-20
CA2411409C (en) 2011-05-17
AU2001264280B2 (en) 2005-08-25
KR20030029058A (ko) 2003-04-11
HK1056163A1 (en) 2004-02-06
CN102617690A (zh) 2012-08-01
KR20060070581A (ko) 2006-06-23
NZ528622A (en) 2005-05-27
EP1295871A4 (en) 2009-02-25
JP2005060402A (ja) 2005-03-10
IL178350A0 (en) 2007-02-11
KR100786053B1 (ko) 2007-12-17
NO20026014L (no) 2003-02-17
CN102617690B (zh) 2015-07-08
US7985744B2 (en) 2011-07-26
KR100734799B1 (ko) 2007-07-03
HK1054373A1 (en) 2003-11-28
CA2664720C (en) 2011-11-22
NO20092832L (no) 2003-02-17
DK1295871T3 (da) 2011-07-11
ATE509910T1 (de) 2011-06-15
IL178350A (en) 2010-11-30
HK1054373B (zh) 2011-11-18
CA2664720A1 (en) 2002-12-04
CN1436170A (zh) 2003-08-13
NO328868B1 (no) 2010-06-07
EP1295871A1 (en) 2003-03-26
IL153395A (en) 2010-06-30
EP1295871B1 (en) 2011-05-18

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