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IL154507A0 - Process for making n-aryl-anthranilic acids and their derivatives - Google Patents

Process for making n-aryl-anthranilic acids and their derivatives

Info

Publication number
IL154507A0
IL154507A0 IL15450701A IL15450701A IL154507A0 IL 154507 A0 IL154507 A0 IL 154507A0 IL 15450701 A IL15450701 A IL 15450701A IL 15450701 A IL15450701 A IL 15450701A IL 154507 A0 IL154507 A0 IL 154507A0
Authority
IL
Israel
Prior art keywords
aryl
derivatives
making
anthranilic acids
anthranilic
Prior art date
Application number
IL15450701A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of IL154507A0 publication Critical patent/IL154507A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL15450701A 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives IL154507A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25
PCT/US2001/022948 WO2002018319A1 (en) 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives

Publications (1)

Publication Number Publication Date
IL154507A0 true IL154507A0 (en) 2003-09-17

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15450701A IL154507A0 (en) 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives

Country Status (31)

Country Link
EP (1) EP1313694A1 (cs)
JP (1) JP2004507518A (cs)
KR (1) KR20030059115A (cs)
CN (1) CN1458921A (cs)
AP (1) AP2001002249A0 (cs)
AR (1) AR032175A1 (cs)
AU (1) AU2001277044A1 (cs)
BG (1) BG107635A (cs)
BR (1) BR0113520A (cs)
CA (1) CA2420003A1 (cs)
CZ (1) CZ2003477A3 (cs)
DO (1) DOP2001000238A (cs)
EA (1) EA200300187A1 (cs)
GT (1) GT200100174A (cs)
HN (1) HN2001000216A (cs)
HU (1) HUP0300828A2 (cs)
IL (1) IL154507A0 (cs)
IS (1) IS6724A (cs)
MA (1) MA26949A1 (cs)
MX (1) MXPA03001654A (cs)
NO (1) NO20030844L (cs)
PA (1) PA8526501A1 (cs)
PE (1) PE20020393A1 (cs)
PL (1) PL360699A1 (cs)
SK (1) SK2072003A3 (cs)
SV (1) SV2002000601A (cs)
TN (1) TNSN01127A1 (cs)
UY (1) UY26908A1 (cs)
WO (1) WO2002018319A1 (cs)
YU (1) YU14303A (cs)
ZA (1) ZA200301182B (cs)

Families Citing this family (37)

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US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
PL233493B1 (pl) 2002-03-13 2019-10-31 Array Biopharma Inc Związek benzoimidazolowy, jego zastosowanie oraz zawierająca go kompozycja farmaceutyczna
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
CA2542210A1 (en) 2003-10-21 2005-05-06 Warner-Lambert Company Llc Polymorphic form of n-[(r)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
RU2351593C2 (ru) 2003-11-19 2009-04-10 Эррэй Биофарма Инк. Гетероциклические ингибиторы мек и способы их применения
EP1684694A2 (en) 2003-11-21 2006-08-02 Array Biopharma, Inc. Akt protein kinase inhibitors
UA89035C2 (ru) * 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
EP1877379B1 (en) 2005-04-13 2013-01-16 Astex Therapeutics Limited Hydroxybenzamide derivatives and their use as inhibitors of hsp90
ES2500068T3 (es) 2005-05-18 2014-09-30 Array Biopharma, Inc. Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
EP2049500B1 (en) 2006-07-06 2011-09-07 Array Biopharma, Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
CN101516891B (zh) 2006-07-06 2013-06-05 阵列生物制药公司 作为akt蛋白激酶抑制剂的二氢噻吩并嘧啶
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JP5721949B2 (ja) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
WO2008044054A2 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in therapy
EP2081891A2 (en) 2006-10-12 2009-07-29 Astex Therapeutics Limited Pharmaceutical compounds having hsp90 inhibitory or modulating activity
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2009006567A2 (en) 2007-07-05 2009-01-08 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
CN101918373B (zh) 2007-07-05 2013-06-05 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
RU2504542C2 (ru) 2008-01-09 2014-01-20 Эррэй Биофарма Инк. Гидроксилированные пиримидилциклопентаны в качестве ингибиторов протеинкиназы (акт)
BRPI0907372A2 (pt) 2008-01-09 2015-07-14 Array Biopharma Inc Pirimidil ciclopentano hidroxilado como inibidor de proteína quinase akt
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
JP2013519714A (ja) * 2010-02-19 2013-05-30 センター ナショナル デ ラ リシェルシェ サイエンティフィック 芳香族求核置換によって目的の化学化合物を調製するための方法
CN102985399A (zh) * 2010-02-19 2013-03-20 国家科学研究中心 通过对携带至少一个吸电子基团的芳香族羧酸衍生物进行亲核芳香族取代来制备目的化合物的方法
EP2694073B1 (en) 2011-04-01 2018-08-08 Genentech, Inc. Combinations of akt and mek inhibitors for treating cancer
HUE036513T2 (hu) 2011-04-01 2018-07-30 Genentech Inc AKT inhibitor vegyület és abirateron kombinációja terápiás kezelésekben való alkalmazásra
PE20151494A1 (es) * 2012-10-12 2015-11-06 Exelixis Inc Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
WO1998037881A1 (en) * 1997-02-28 1998-09-03 Warner Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
ATE277895T1 (de) * 1997-07-01 2004-10-15 Warner Lambert Co 4-brom or 4-iod-phenylamino- benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren
NZ501277A (en) * 1997-07-01 2002-12-20 Warner Lambert Co -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
WO2000064856A1 (en) * 1999-04-21 2000-11-02 Warner-Lambert Company Method for making 2-(n-phenylamino)benzoic acids

Also Published As

Publication number Publication date
WO2002018319A1 (en) 2002-03-07
IS6724A (is) 2003-02-20
ZA200301182B (en) 2004-05-12
TNSN01127A1 (en) 2005-11-10
EA200300187A1 (ru) 2003-08-28
UY26908A1 (es) 2001-11-30
SV2002000601A (es) 2002-04-03
BR0113520A (pt) 2003-06-24
MXPA03001654A (es) 2004-09-10
HUP0300828A2 (hu) 2003-09-29
MA26949A1 (fr) 2004-12-20
EP1313694A1 (en) 2003-05-28
HN2001000216A (es) 2002-05-22
KR20030059115A (ko) 2003-07-07
DOP2001000238A (es) 2003-01-31
YU14303A (sh) 2006-08-17
SK2072003A3 (en) 2004-01-08
AP2001002249A0 (en) 2001-09-30
PL360699A1 (en) 2004-09-20
NO20030844D0 (no) 2003-02-24
PA8526501A1 (es) 2002-07-30
NO20030844L (no) 2003-02-25
CZ2003477A3 (cs) 2003-10-15
GT200100174A (es) 2002-07-18
JP2004507518A (ja) 2004-03-11
PE20020393A1 (es) 2002-05-09
BG107635A (bg) 2004-09-30
CA2420003A1 (en) 2002-03-07
AU2001277044A1 (en) 2002-03-13
AR032175A1 (es) 2003-10-29
CN1458921A (zh) 2003-11-26

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