IE37370L - 2, 6-diamino-dihydropyridines - Google Patents
2, 6-diamino-dihydropyridinesInfo
- Publication number
- IE37370L IE37370L IE730346A IE34673A IE37370L IE 37370 L IE37370 L IE 37370L IE 730346 A IE730346 A IE 730346A IE 34673 A IE34673 A IE 34673A IE 37370 L IE37370 L IE 37370L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- radical
- chain
- march
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1379005 Dihydropyridines BAYER AG 6 March 1973 [6 March 1972 12 Sept 1972] 10759/73 Heading C2C The invention comprises novel compounds of the tautomeric formulae in which R is a saturated or unsaturated, straight-chain, branched or cyclic hydrocarbon radical, or an aryl radical optionally carrying 1, 2 or 3 identical or different substitutents selected from aryl, alkyl, alkoxy, azido, halogen, nitro, cyano, trifluoromethyl, carbalkoxy and -SO n -Alkyl (in which n = 0, 1 or 2) radicals, or a naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thenyl, furyl or pyrryl radical optionally carrying at least one substituent selected from alkyl, alkoxy and halogen radicals; and R<SP>1</SP> and R<SP>2</SP> which can be the same or different, are each a radical -OR<SP>1</SP> in which R<SP>1</SP> is a straight-chain, branched or cyclic, saturated or unsaturated aliphatic hydrocarbon radical the carbon chain of which may be interrupted by 1 or 2 oxygen atoms, or an amino, alkylamino, or dialkylamino group. They are made by reacting an amidine of formula with RCHO or with an ylidene cyanoacetic acid derivative of formula R<SP>1</SP>OC-C(.CN)(:CHR). Pharmaceutical preparations especially useful as coronary and anti-hypertensive agents contain the novel compounds as active ingredients; standard administration forms are described.
[GB1379005A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2210687A DE2210687C3 (en) | 1972-03-06 | 1972-03-06 | 2,6-diamino-3,5-diethoxycarbonyldihydropyridines, process for their preparation and pharmaceuticals containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37370L true IE37370L (en) | 1973-09-06 |
| IE37370B1 IE37370B1 (en) | 1977-07-06 |
Family
ID=5838037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE346/73A IE37370B1 (en) | 1972-03-06 | 1973-03-05 | New 2,6-diamino-dihydropyridines their production and their medicinal use |
Country Status (24)
| Country | Link |
|---|---|
| JP (2) | JPS5626659B2 (en) |
| KR (1) | KR780000119B1 (en) |
| AT (3) | AT327904B (en) |
| BE (1) | BE796279A (en) |
| BG (2) | BG20583A3 (en) |
| CA (1) | CA988524A (en) |
| CH (2) | CH580589A5 (en) |
| CS (2) | CS182792B2 (en) |
| DD (1) | DD106833A5 (en) |
| DE (1) | DE2210687C3 (en) |
| DK (1) | DK136061C (en) |
| ES (1) | ES412323A1 (en) |
| FI (1) | FI55996C (en) |
| FR (1) | FR2181789B1 (en) |
| GB (1) | GB1379005A (en) |
| HU (1) | HU167089B (en) |
| IE (1) | IE37370B1 (en) |
| IL (1) | IL41664A (en) |
| LU (1) | LU67147A1 (en) |
| NL (1) | NL7303137A (en) |
| PL (2) | PL92078B1 (en) |
| RO (2) | RO63068A (en) |
| SE (1) | SE384208B (en) |
| ZA (1) | ZA731501B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2210687C3 (en) * | 1972-03-06 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | 2,6-diamino-3,5-diethoxycarbonyldihydropyridines, process for their preparation and pharmaceuticals containing them |
| DE2406198C2 (en) * | 1974-02-09 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Process for the preparation of new 2-amino-6-dialkylamino-dihydropyridines |
| JPS5922594U (en) * | 1982-08-03 | 1984-02-10 | 日本マランツ株式会社 | earplug type headphone |
| JPS5922593U (en) * | 1982-08-03 | 1984-02-10 | 日本マランツ株式会社 | Horn mounting structure for headphone |
| JPS6282898A (en) * | 1985-10-08 | 1987-04-16 | Matsushita Electric Ind Co Ltd | Headphone |
| JPS6293060U (en) * | 1985-11-28 | 1987-06-13 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3855231A (en) * | 1972-03-06 | 1974-12-17 | Bayer Ag | 2,6-diamino-1,4-dihydropyridine derivatives |
| DE2210687C3 (en) * | 1972-03-06 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | 2,6-diamino-3,5-diethoxycarbonyldihydropyridines, process for their preparation and pharmaceuticals containing them |
| DE2406198C2 (en) * | 1974-02-09 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Process for the preparation of new 2-amino-6-dialkylamino-dihydropyridines |
-
1972
- 1972-03-06 DE DE2210687A patent/DE2210687C3/en not_active Expired
-
1973
- 1973-02-13 RO RO7300082647A patent/RO63068A/ro unknown
- 1973-02-13 RO RO73832A patent/RO61192A/ro unknown
- 1973-02-26 DD DD169048A patent/DD106833A5/xx unknown
- 1973-02-28 BG BG024472A patent/BG20583A3/en unknown
- 1973-02-28 BG BG022858A patent/BG22815A3/en unknown
- 1973-03-02 CH CH313273A patent/CH580589A5/xx not_active IP Right Cessation
- 1973-03-02 LU LU67147A patent/LU67147A1/xx unknown
- 1973-03-02 CH CH220176A patent/CH577473A5/xx not_active IP Right Cessation
- 1973-03-02 JP JP2445273A patent/JPS5626659B2/ja not_active Expired
- 1973-03-02 IL IL7341664A patent/IL41664A/en unknown
- 1973-03-02 FI FI657/73A patent/FI55996C/en active
- 1973-03-03 PL PL1973182270A patent/PL92078B1/pl unknown
- 1973-03-03 PL PL1973161010A patent/PL89256B1/pl unknown
- 1973-03-05 SE SE7303021A patent/SE384208B/en unknown
- 1973-03-05 CA CA165,209A patent/CA988524A/en not_active Expired
- 1973-03-05 ZA ZA731501A patent/ZA731501B/en unknown
- 1973-03-05 IE IE346/73A patent/IE37370B1/en unknown
- 1973-03-05 KR KR7300356A patent/KR780000119B1/en active
- 1973-03-05 ES ES412323A patent/ES412323A1/en not_active Expired
- 1973-03-05 DK DK118073A patent/DK136061C/en active
- 1973-03-05 BE BE128374A patent/BE796279A/en not_active IP Right Cessation
- 1973-03-06 AT AT925774*7A patent/AT327904B/en not_active IP Right Cessation
- 1973-03-06 HU HUBA2892A patent/HU167089B/hu unknown
- 1973-03-06 CS CS7500003602A patent/CS182792B2/en unknown
- 1973-03-06 FR FR7307923A patent/FR2181789B1/fr not_active Expired
- 1973-03-06 CS CS7300001593A patent/CS182781B2/en unknown
- 1973-03-06 NL NL7303137A patent/NL7303137A/xx not_active Application Discontinuation
- 1973-03-06 AT AT925774A patent/ATA925774A/en unknown
- 1973-03-06 GB GB1075973A patent/GB1379005A/en not_active Expired
- 1973-03-06 AT AT197373A patent/AT324338B/en not_active IP Right Cessation
-
1980
- 1980-12-27 JP JP55185147A patent/JPS5911584B2/en not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1384031A (en) | N-substituted dihydropyridine compounds their production and their medicinal use | |
| IE37538L (en) | 1, 4-dihydropyridine carboxylic acid compounds | |
| IE36265L (en) | 1,4-dihydropyridinedicarboxylic acid esters | |
| FI900307A0 (en) | Process for the preparation of therapeutically active 3- [3-oxo- (2,3) -dihydropyridazin-6-yl] -2-phenylpyrazolo [1,5-a] pyridine derivatives | |
| GB1477114A (en) | 1,4-dihydropyridinecarboxylic acid aralkyl esters processes for their preparation and their use as medicaments | |
| RU93035829A (en) | Aminoquinolone derivatives substituted by an aryl or heteroaromatic group and anti-HIV drugs | |
| UA41244C2 (en) | Derivatives of propene acid having fungicide activity | |
| IE36947L (en) | 14 - dihydropyridinecarboxycic acid esters | |
| GB1384504A (en) | Bridgeheadheterocyclic compounds their production and their medicinal use | |
| GB1389509A (en) | Dihydropyridinepolyesters their production and their medicinal use | |
| IE42668L (en) | Salicylanilide derivatives | |
| ATE39357T1 (en) | DERIVATIVES OF GRISEOLIC ACID AND THEIR USE. | |
| IE37370L (en) | 2, 6-diamino-dihydropyridines | |
| GB1389504A (en) | 2-amino-1,4-dihydropyridines their production and their medicinal use | |
| KR880009021A (en) | Pyrazolo [3,4-d] pyrimidine derivatives, compositions and uses thereof | |
| EP0191724A3 (en) | 1,4-dihydropyridine derivatives, their preparation and pharmaceutical compositions containing them | |
| IT1216104B (en) | PEPTIDES WITH PHARMACEUTICAL ACTIVITY. | |
| IE38141L (en) | 3, 4-dihydropyridones. | |
| IE37367L (en) | 2-amino-4, 5-dihydropyridine-3, 5-dicarboxylic acid esters | |
| IE38064L (en) | 2-amino-4h-pyran derivatives. | |
| PT84101A (en) | NOVEL AMIDES SUBSTITUTED FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| GB1271147A (en) | Novel 2,3-disubstituted quinazolinone derivatives | |
| GB1368546A (en) | Partially hydrogenated benzoquinolizines their manufacture and their medicinal use | |
| GB1329908A (en) | Pyridine derivatives | |
| GB1173304A (en) | A Process for the Manufacture of Benzoxadiaz[4,1,5]Ocines |