ID19773A - Turunan-turunan 1,3,8-triaza-spiro (4,5) dekan-4-ona tersubtitusi-8 - Google Patents
Turunan-turunan 1,3,8-triaza-spiro (4,5) dekan-4-ona tersubtitusi-8Info
- Publication number
- ID19773A ID19773A IDP980073A ID980073A ID19773A ID 19773 A ID19773 A ID 19773A ID P980073 A IDP980073 A ID P980073A ID 980073 A ID980073 A ID 980073A ID 19773 A ID19773 A ID 19773A
- Authority
- ID
- Indonesia
- Prior art keywords
- durunan
- durun
- dekan
- triaza
- spiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97101409 | 1997-01-30 | ||
EP97119311 | 1997-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID19773A true ID19773A (id) | 1998-07-30 |
Family
ID=26145196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDP980073A ID19773A (id) | 1997-01-30 | 1998-01-22 | Turunan-turunan 1,3,8-triaza-spiro (4,5) dekan-4-ona tersubtitusi-8 |
Country Status (34)
Country | Link |
---|---|
US (1) | US6071925A (id) |
EP (1) | EP0856514B1 (id) |
JP (1) | JP3292457B2 (id) |
KR (1) | KR100274107B1 (id) |
CN (1) | CN1113881C (id) |
AR (1) | AR011576A1 (id) |
AT (1) | ATE202105T1 (id) |
AU (1) | AU730147B2 (id) |
BR (1) | BR9800524B1 (id) |
CA (1) | CA2226058C (id) |
CO (1) | CO4920223A1 (id) |
CZ (1) | CZ27398A3 (id) |
DE (1) | DE69800896T2 (id) |
DK (1) | DK0856514T3 (id) |
EA (1) | EA001357B1 (id) |
ES (1) | ES2158622T3 (id) |
GR (1) | GR3036523T3 (id) |
HR (1) | HRP980043B1 (id) |
HU (1) | HUP9800138A3 (id) |
ID (1) | ID19773A (id) |
IL (1) | IL123036A (id) |
MA (1) | MA26470A1 (id) |
NO (1) | NO310026B1 (id) |
NZ (1) | NZ329627A (id) |
PE (1) | PE59999A1 (id) |
PL (1) | PL324571A1 (id) |
PT (1) | PT856514E (id) |
SG (1) | SG71077A1 (id) |
SI (1) | SI0856514T1 (id) |
TR (1) | TR199800085A3 (id) |
TW (1) | TW457238B (id) |
UY (1) | UY24865A1 (id) |
YU (1) | YU2098A (id) |
ZA (1) | ZA98570B (id) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2170446T3 (es) * | 1997-12-05 | 2002-08-01 | Hoffmann La Roche | Derivados de 1,3,8-triaza-espiro(4,5)decan-4-ona. |
SI0921125T1 (en) * | 1997-12-05 | 2002-04-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro(4,5)decan-4-on derivatives |
US6166209A (en) * | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
US6277991B1 (en) | 1998-05-18 | 2001-08-21 | Novo Nordisk A/S | 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes |
DE69902606T2 (de) * | 1998-06-12 | 2003-04-24 | F. Hoffmann-La Roche Ag, Basel | Spiro(piperidin-4,1'-pyrrolo(3,4-c)pyrrole) |
ES2194402T3 (es) * | 1998-06-12 | 2003-11-16 | Hoffmann La Roche | Derivados de di - o triaza-espiro(4,5)decano.. |
US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
CO5150201A1 (es) * | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
ES2237047T3 (es) * | 1998-10-23 | 2005-07-16 | Pfizer Inc. | Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1. |
AU1185300A (en) * | 1998-11-20 | 2000-06-13 | Banyu Pharmaceutical Co., Ltd. | 2-oxoimidazole derivatives |
GB9900078D0 (en) * | 1999-01-05 | 1999-02-24 | Zeneca Ltd | Chemical compounds |
GB9914024D0 (en) * | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
AU1382901A (en) * | 1999-11-17 | 2001-05-30 | Novo Nordisk A/S | Novel triazaspirodecanones with high affinity for opioid receptor subtypes |
US6686370B2 (en) | 1999-12-06 | 2004-02-03 | Euro-Celtique S.A. | Triazospiro compounds having nociceptin receptor affinity |
US6794389B2 (en) | 2000-03-31 | 2004-09-21 | Nippon Shinyaku Co., Ltd. | Quinazoline derivatives and drugs |
CA2443868C (en) * | 2001-04-10 | 2011-01-25 | Ortho-Mcneil Pharmaceutical, Inc. | 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders |
WO2003004034A1 (en) | 2001-07-02 | 2003-01-16 | Omeros Corporation | Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump |
US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
JP4056977B2 (ja) | 2002-03-29 | 2008-03-05 | 田辺三菱製薬株式会社 | 睡眠障害治療薬 |
US6995168B2 (en) | 2002-05-31 | 2006-02-07 | Euro-Celtique S.A. | Triazaspiro compounds useful for treating or preventing pain |
EA009369B1 (ru) * | 2002-09-09 | 2007-12-28 | Янссен Фармацевтика, Н.В. | Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором |
ZA200510329B (en) * | 2003-05-23 | 2007-04-25 | Zealand Pharma As | Triaza-spiro compounds as nociceptin analogues and uses thereof |
SA04250305B1 (ar) | 2003-09-25 | 2008-06-02 | سولفاي فارماسوتيكالز بي . في | مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية |
US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
US8703948B2 (en) * | 2006-11-28 | 2014-04-22 | Janssen Pharmaceutica Nv | Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one |
JP5313865B2 (ja) * | 2007-03-01 | 2013-10-09 | 田辺三菱製薬株式会社 | ベンゾイミダゾール化合物およびその医薬用途 |
US8741916B2 (en) * | 2007-04-09 | 2014-06-03 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor |
TW201016675A (en) * | 2008-09-16 | 2010-05-01 | Mitsubishi Tanabe Pharma Corp | Crystalline benzoimidazole compound and salt thereof |
US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
EP3383390A4 (en) * | 2015-12-02 | 2019-11-20 | Astraea Therapeutics, LLC | PIPERIDINYL COMPOUNDS FOR NOCICEPTIN RECEPTOR |
CN106397225A (zh) * | 2016-09-04 | 2017-02-15 | 王际菊 | 一种手性化合物的制备方法 |
CN106467476A (zh) * | 2016-09-04 | 2017-03-01 | 王际菊 | 一种左旋胺基化合物的合成方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US488082A (en) * | 1892-12-13 | Automatic gut-off for gas bxxenees | ||
JPS5212171A (en) * | 1975-07-17 | 1977-01-29 | Yoshitomi Pharmaceut Ind Ltd | Process for preparation of cyclohexane derivatives |
US4076821A (en) * | 1976-02-27 | 1978-02-28 | Yoshitomi Pharmaceutical Industries, Ltd. | 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof |
US4126687A (en) * | 1976-05-17 | 1978-11-21 | Janssen Pharmaceutica N.V. | Antiemetic, 1-(benzimidazolyl-alkyl)-piperidine derivatives |
US4329353A (en) * | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
SU1095878A3 (ru) * | 1980-10-22 | 1984-05-30 | Жансен Фармасетика Н.В. (Фирма) | Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм |
US4374245A (en) * | 1982-04-09 | 1983-02-15 | Hoechst-Roussel Pharmaceuticals Inc. | 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
JPS6012357B2 (ja) * | 1984-01-23 | 1985-04-01 | 吉富製薬株式会社 | 脂環式誘導体 |
US4707484A (en) * | 1986-11-25 | 1987-11-17 | Hoffmann-La Roche Inc. | Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives |
US5153225A (en) * | 1986-12-10 | 1992-10-06 | Bayer Aktiengesellschaft | Substituted basic 2-aminotetralin in pharmaceuticals |
DE3718317A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte basische 2-aminotetraline |
US5039804A (en) * | 1989-12-13 | 1991-08-13 | Glaxo Inc. | Preparation of substituted alkali metal piperidine-4-carboxylates |
DE4135473A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | Triazaspirodecanon-methylchromane |
DE4405178A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika |
-
1997
- 1997-12-31 CA CA002226058A patent/CA2226058C/en not_active Expired - Fee Related
-
1998
- 1998-01-07 SG SG1998000062A patent/SG71077A1/en unknown
- 1998-01-15 YU YU2098A patent/YU2098A/sh unknown
- 1998-01-20 US US09/009,457 patent/US6071925A/en not_active Expired - Fee Related
- 1998-01-20 TR TR1998/00085A patent/TR199800085A3/tr unknown
- 1998-01-21 ES ES98100970T patent/ES2158622T3/es not_active Expired - Lifetime
- 1998-01-21 DE DE69800896T patent/DE69800896T2/de not_active Expired - Lifetime
- 1998-01-21 DK DK98100970T patent/DK0856514T3/da active
- 1998-01-21 SI SI9830035T patent/SI0856514T1/xx unknown
- 1998-01-21 AT AT98100970T patent/ATE202105T1/de active
- 1998-01-21 PT PT98100970T patent/PT856514E/pt unknown
- 1998-01-21 EP EP98100970A patent/EP0856514B1/en not_active Expired - Lifetime
- 1998-01-22 ID IDP980073A patent/ID19773A/id unknown
- 1998-01-23 ZA ZA98570A patent/ZA98570B/xx unknown
- 1998-01-23 IL IL12303698A patent/IL123036A/xx not_active IP Right Cessation
- 1998-01-23 CN CN98103687A patent/CN1113881C/zh not_active Expired - Fee Related
- 1998-01-23 NZ NZ329627A patent/NZ329627A/xx unknown
- 1998-01-26 HU HU9800138A patent/HUP9800138A3/hu unknown
- 1998-01-26 NO NO980332A patent/NO310026B1/no not_active IP Right Cessation
- 1998-01-27 HR HR980043A patent/HRP980043B1/xx not_active IP Right Cessation
- 1998-01-27 JP JP01371198A patent/JP3292457B2/ja not_active Expired - Fee Related
- 1998-01-27 PE PE1998000056A patent/PE59999A1/es not_active Application Discontinuation
- 1998-01-27 AR ARP980100349A patent/AR011576A1/es active IP Right Grant
- 1998-01-28 MA MA24950A patent/MA26470A1/fr unknown
- 1998-01-28 CO CO98003944A patent/CO4920223A1/es unknown
- 1998-01-29 AU AU52809/98A patent/AU730147B2/en not_active Ceased
- 1998-01-29 PL PL98324571A patent/PL324571A1/xx unknown
- 1998-01-29 CZ CZ98273A patent/CZ27398A3/cs unknown
- 1998-01-29 UY UY24865A patent/UY24865A1/es unknown
- 1998-01-30 BR BRPI9800524-3A patent/BR9800524B1/pt not_active IP Right Cessation
- 1998-01-30 KR KR1019980002475A patent/KR100274107B1/ko not_active IP Right Cessation
- 1998-01-30 EA EA199800108A patent/EA001357B1/ru not_active IP Right Cessation
- 1998-02-04 TW TW087101434A patent/TW457238B/zh not_active IP Right Cessation
-
2001
- 2001-09-05 GR GR20010401383T patent/GR3036523T3/el unknown
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