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HUP9902136A2 - Szubsztituált ciklusos aminosavszármazékok, alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Szubsztituált ciklusos aminosavszármazékok, alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9902136A2
HUP9902136A2 HU9902136A HUP9902136A HUP9902136A2 HU P9902136 A2 HUP9902136 A2 HU P9902136A2 HU 9902136 A HU9902136 A HU 9902136A HU P9902136 A HUP9902136 A HU P9902136A HU P9902136 A2 HUP9902136 A2 HU P9902136A2
Authority
HU
Hungary
Prior art keywords
compounds
disorders
amino acid
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU9902136A
Other languages
English (en)
Inventor
Justin S. Bryans
Johannes Hartenstein
David Christopher Horwell
Clare O. Kneen
Andrew I. Morrell
Giles S. Ratcliffe
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of HUP9902136A2 publication Critical patent/HUP9902136A2/hu
Publication of HUP9902136A3 publication Critical patent/HUP9902136A3/hu
Publication of HU224720B1 publication Critical patent/HU224720B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány szerinti vegyületek (I) általánős képletében R1, R2, R3,R4, R5, R6, R7, R8, R9 és R10 mindegyikének jelentése alkilcsőpőrt,adőtt esetben szűbsztitűált benzil- vagy fenilcsőpőrt, ahől a benzil-és fenilcsőpőrt szűbsztitűensei a következő atőmők és csőpőrtők közülkerülnek kiválasztásra: halőgénatőm, alkőxi-, alkil-, hidrőxi-,karbőxil-, alkőxi-karbőnil-, triflűőr-metil- és nitrőcsőpőrt; ésbármely R1-R10, amely nem a fentiek egyike, hidrőgénatőmőt jelent -, Atalálmány tárgya tővábbá a fenti vegyületek gyógyászatila elfőgadhatósói és prődrőgjai is. A találmány szerinti vegyületek példáűl akövetkező rendellenességek kezelésére alkalmazhatók: epilepszia,ájűlásős rőhamők, hipőkinézis, kőpőnya-rendellenességek,neűrődegeneratív rendellenességek, depresszió, anxietas, pánik,fájdalőm és neűrőpatőlógiás rendellenességek. (I) ŕ
HU9902136A 1996-03-14 1997-02-18 Novel substituted cyclic amino acid derivatives use as pharmaceutical agents HU224720B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1343296P 1996-03-14 1996-03-14
PCT/US1997/002295 WO1997033858A1 (en) 1996-03-14 1997-02-18 Novel substituted cyclic amino acids as pharmaceutical agents

Publications (3)

Publication Number Publication Date
HUP9902136A2 true HUP9902136A2 (hu) 1999-10-28
HUP9902136A3 HUP9902136A3 (en) 2000-03-28
HU224720B1 HU224720B1 (en) 2006-01-30

Family

ID=21759938

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902136A HU224720B1 (en) 1996-03-14 1997-02-18 Novel substituted cyclic amino acid derivatives use as pharmaceutical agents

Country Status (29)

Country Link
US (1) US6103932A (hu)
EP (1) EP0888286B1 (hu)
JP (1) JP2000506861A (hu)
KR (1) KR100512506B1 (hu)
AT (1) ATE207878T1 (hu)
AU (1) AU734173B2 (hu)
BG (1) BG63662B1 (hu)
BR (1) BR9708200A (hu)
CA (1) CA2244912C (hu)
CZ (1) CZ293759B6 (hu)
DE (1) DE69707842T2 (hu)
DK (2) DK0888286T3 (hu)
EA (1) EA002765B1 (hu)
EE (1) EE9800309A (hu)
ES (1) ES2167717T3 (hu)
GE (1) GEP20012413B (hu)
HU (1) HU224720B1 (hu)
IL (1) IL125544A (hu)
IS (1) IS1990B (hu)
MX (1) MX9806069A (hu)
NO (1) NO984205L (hu)
NZ (1) NZ331143A (hu)
PL (1) PL185991B1 (hu)
PT (1) PT888286E (hu)
SK (1) SK283295B6 (hu)
TR (1) TR199801807T2 (hu)
UA (1) UA49011C2 (hu)
WO (1) WO1997033858A1 (hu)
ZA (1) ZA972200B (hu)

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Also Published As

Publication number Publication date
KR100512506B1 (ko) 2005-12-21
IL125544A0 (en) 1999-03-12
ATE207878T1 (de) 2001-11-15
BG102733A (en) 1999-04-30
WO1997033858A1 (en) 1997-09-18
GEP20012413B (en) 2001-04-25
CA2244912C (en) 2005-07-12
ZA972200B (en) 1997-09-17
HUP9902136A3 (en) 2000-03-28
UA49011C2 (uk) 2002-09-16
DE69707842T2 (de) 2002-05-16
BR9708200A (pt) 1999-07-27
MX9806069A (es) 1998-11-30
AU2051197A (en) 1997-10-01
EA002765B1 (ru) 2002-08-29
AU734173B2 (en) 2001-06-07
CZ286398A3 (cs) 1999-03-17
NO984205L (no) 1998-09-14
CA2244912A1 (en) 1997-09-18
EP0888286B1 (en) 2001-10-31
CZ293759B6 (cs) 2004-07-14
BG63662B1 (bg) 2002-08-30
ES2167717T3 (es) 2002-05-16
PL328816A1 (en) 1999-02-15
SK123898A3 (en) 2000-04-10
NO984205D0 (no) 1998-09-11
US6103932A (en) 2000-08-15
EE9800309A (et) 1999-02-15
IS4819A (is) 1998-08-10
PT888286E (pt) 2002-04-29
DE69707842D1 (de) 2001-12-06
SK283295B6 (sk) 2003-05-02
HU224720B1 (en) 2006-01-30
NZ331143A (en) 2001-06-29
KR19990087756A (ko) 1999-12-27
PL185991B1 (pl) 2003-09-30
TR199801807T2 (xx) 1998-12-21
JP2000506861A (ja) 2000-06-06
DK0888286T3 (da) 2002-02-18
DK0888285T3 (da) 2002-04-08
EP0888286A1 (en) 1999-01-07
IS1990B (is) 2005-02-15
EA199800798A1 (ru) 1999-04-29
IL125544A (en) 2002-03-10

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