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HUP0104623A2 - Ciklosporin oldat, azt tartalmazó gyógyszerkészítmény és alkalmazása - Google Patents

Ciklosporin oldat, azt tartalmazó gyógyszerkészítmény és alkalmazása

Info

Publication number
HUP0104623A2
HUP0104623A2 HU0104623A HUP0104623A HUP0104623A2 HU P0104623 A2 HUP0104623 A2 HU P0104623A2 HU 0104623 A HU0104623 A HU 0104623A HU P0104623 A HUP0104623 A HU P0104623A HU P0104623 A2 HUP0104623 A2 HU P0104623A2
Authority
HU
Hungary
Prior art keywords
ciclosporin
water
preparation
solution
active substance
Prior art date
Application number
HU0104623A
Other languages
English (en)
Inventor
Wilfried Fischer
Original Assignee
Ratiopharm Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh. filed Critical Ratiopharm Gmbh.
Publication of HUP0104623A2 publication Critical patent/HUP0104623A2/hu
Publication of HUP0104623A3 publication Critical patent/HUP0104623A3/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A tal lm ny egy ciklosporin oldatra vonatkozik, amelyet kiz rólagvízzel elegyíthető segédanyagokkal, amilyen a dexpantenol, egy anionostenzid és egy nemionos tenzid vagy nemionos tenzidek keveréke,llítanak elő. A hatóanyag ilyen k"rülmények k"z"tt vízben stabilkolloid oldatokat képez és ezek vízzel tetszés szerint hígíthatókanélkül, hogy a ciklosporin kicsapódna. A biológiai tolerancia vizsglatok arra mutattak, hogy a hatóanyag or lis bevitel ut n jól abszorbelódik. Az előnyben részesített ciklosporin a ciklosporin A. A tal lmny t rgy t képezi a ciklosporint tartalmazó gyógyszerkészítmény is,amelynek alakja előny"sen iható oldat vagy ezt tartalmazó kapszula. Atal lm ny szerinti készítmény alkalmazható az immunrendszert blokkolóor lis gyógyszerkészítmény elő llít s ra. Ó
HU0104623A 1998-12-23 1999-12-23 Cyclosporin solution, pharmaceutical composition comprising thereof and its use HUP0104623A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19859910A DE19859910C2 (de) 1998-12-23 1998-12-23 Orales Arzneimittel
PCT/EP1999/010358 WO2000038702A1 (de) 1998-12-23 1999-12-23 Cyclosporin-lösung

Publications (2)

Publication Number Publication Date
HUP0104623A2 true HUP0104623A2 (hu) 2002-04-29
HUP0104623A3 HUP0104623A3 (en) 2002-08-28

Family

ID=7892567

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104623A HUP0104623A3 (en) 1998-12-23 1999-12-23 Cyclosporin solution, pharmaceutical composition comprising thereof and its use

Country Status (18)

Country Link
EP (1) EP1140135B1 (hu)
JP (1) JP2002533401A (hu)
AT (1) ATE249834T1 (hu)
AU (1) AU762963B2 (hu)
CA (1) CA2355271A1 (hu)
CZ (1) CZ20012143A3 (hu)
DE (2) DE19859910C2 (hu)
DK (1) DK1140135T3 (hu)
ES (1) ES2203235T3 (hu)
HK (1) HK1037140A1 (hu)
HU (1) HUP0104623A3 (hu)
NO (1) NO20012932D0 (hu)
PL (1) PL348180A1 (hu)
PT (1) PT1140135E (hu)
RU (1) RU2216342C2 (hu)
SK (1) SK8702001A3 (hu)
WO (1) WO2000038702A1 (hu)
ZA (1) ZA200104828B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
DE102009037551A1 (de) 2009-08-17 2011-02-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cyclosporinderivate
DE102011111991A1 (de) 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
DK0695177T3 (da) * 1993-04-20 1998-09-28 Hexal Ag Plaster indeholdende aktivt stof
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
JP4718653B2 (ja) * 1997-03-12 2011-07-06 アボツト・ラボラトリーズ シクロスポリンの投与のための親水性二成分系

Also Published As

Publication number Publication date
DE19859910C2 (de) 2001-03-22
EP1140135A1 (de) 2001-10-10
NO20012932L (no) 2001-06-13
ATE249834T1 (de) 2003-10-15
PT1140135E (pt) 2003-12-31
AU3043400A (en) 2000-07-31
ES2203235T3 (es) 2004-04-01
JP2002533401A (ja) 2002-10-08
ZA200104828B (en) 2002-09-13
DE59907058D1 (en) 2003-10-23
EP1140135B1 (de) 2003-09-17
RU2216342C2 (ru) 2003-11-20
HUP0104623A3 (en) 2002-08-28
CA2355271A1 (en) 2000-07-06
DE19859910A1 (de) 2000-06-29
SK8702001A3 (en) 2002-01-07
HK1037140A1 (en) 2002-02-01
AU762963B2 (en) 2003-07-10
NO20012932D0 (no) 2001-06-13
WO2000038702A1 (de) 2000-07-06
CZ20012143A3 (cs) 2002-01-16
DK1140135T3 (da) 2003-12-08
PL348180A1 (en) 2002-05-06

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees