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HUP0103093A2 - MRS inhibitorokként és baktericidekként alkalmazható kinolonok és eljárás az előállításukra - Google Patents

MRS inhibitorokként és baktericidekként alkalmazható kinolonok és eljárás az előállításukra

Info

Publication number
HUP0103093A2
HUP0103093A2 HU0103093A HUP0103093A HUP0103093A2 HU P0103093 A2 HUP0103093 A2 HU P0103093A2 HU 0103093 A HU0103093 A HU 0103093A HU P0103093 A HUP0103093 A HU P0103093A HU P0103093 A2 HUP0103093 A2 HU P0103093A2
Authority
HU
Hungary
Prior art keywords
bactericides
preparation
mrs
inhibitors
quinolones
Prior art date
Application number
HU0103093A
Other languages
English (en)
Inventor
John Michael Berge
Pamela Brown
John Stephen Elder
Andrew Keith Forrest
Dieter Wolfgang Hamprecht
Richard Lewis Jarvest
David Jonathan Mcnair
Robert John Sheppard
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809050.9A external-priority patent/GB9809050D0/en
Priority claimed from GBGB9824571.5A external-priority patent/GB9824571D0/en
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of HUP0103093A2 publication Critical patent/HUP0103093A2/hu
Publication of HUP0103093A3 publication Critical patent/HUP0103093A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
HU0103093A 1998-04-29 1999-04-15 Quinolones used as mrs inhibitors and bactericides and process for their preparation HUP0103093A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9809050.9A GB9809050D0 (en) 1998-04-29 1998-04-29 Novel compounds
GBGB9824571.5A GB9824571D0 (en) 1998-11-09 1998-11-09 Novel compounds
PCT/EP1999/002648 WO1999055677A1 (en) 1998-04-29 1999-04-15 Quinolones used as mrs inhibitors and bactericides

Publications (2)

Publication Number Publication Date
HUP0103093A2 true HUP0103093A2 (hu) 2002-02-28
HUP0103093A3 HUP0103093A3 (en) 2002-03-28

Family

ID=26313554

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103093A HUP0103093A3 (en) 1998-04-29 1999-04-15 Quinolones used as mrs inhibitors and bactericides and process for their preparation

Country Status (16)

Country Link
US (1) US6320051B1 (hu)
EP (1) EP1084110A1 (hu)
JP (1) JP2002513005A (hu)
KR (1) KR20010043131A (hu)
CN (1) CN1307565A (hu)
AR (1) AR018199A1 (hu)
AU (1) AU3523599A (hu)
BR (1) BR9909994A (hu)
CA (1) CA2330564A1 (hu)
CO (1) CO5080763A1 (hu)
HU (1) HUP0103093A3 (hu)
IL (1) IL138906A0 (hu)
NO (1) NO20005400L (hu)
PL (1) PL343680A1 (hu)
TR (1) TR200003170T2 (hu)
WO (1) WO1999055677A1 (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014121A1 (en) * 1996-04-18 2004-01-22 Smithkline Beecham Corporation Novel compounds
GB9822241D0 (en) * 1998-10-12 1998-12-09 Smithkline Beecham Plc Novel compounds
GB9827467D0 (en) * 1998-12-15 1999-02-10 Zeneca Ltd Chemical compounds
EP1466603A3 (en) * 1999-05-05 2004-10-20 Merck & Co., Inc. Novel catechols as antimicrobial agents
DE60012502T2 (de) * 1999-05-05 2005-07-28 Merck & Co., Inc. Neue cathechole als antimikrobielle mittel
AU5213300A (en) * 1999-05-19 2000-12-12 Smithkline Beecham Plc 2-nh-pyridones and pyrimidones as mrs inhibitors
GB9911594D0 (en) * 1999-05-19 1999-07-21 Smithkline Beecham Plc Novel compounds
WO2002047687A1 (en) * 2000-12-11 2002-06-20 Smithkline Beecham Corporation Urotensin-ii receptor antagonists
WO2002047456A2 (en) * 2000-12-11 2002-06-20 Smithkline Beecham Corporation Urotensin-ii receptor antagonists
US6818655B2 (en) 2001-01-26 2004-11-16 Smithkline Beecham Corporation Urotensin-II receptor antagonists
SE0202134D0 (sv) * 2002-07-08 2002-07-08 Astrazeneca Ab Therapeutic agents
ES2401319T3 (es) 2002-12-20 2013-04-18 Glaxo Group Limited Nuevo derivado de benzazepina
JP2006519261A (ja) * 2003-03-03 2006-08-24 レプリダイン・インコーポレーテッド 抗菌活性を有する置換されたチオフェン
GB0304809D0 (en) * 2003-03-03 2003-04-09 Glaxo Group Ltd Novel compounds
US20040224981A1 (en) * 2003-05-01 2004-11-11 Nebojsa Janjic Antibacterial methods and compositions
WO2005066132A1 (en) * 2004-01-07 2005-07-21 Astrazeneca Ab Therapeutic agents i
JO3077B1 (ar) * 2005-07-28 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينولين مضادة للبكتيريا
FR2902100A1 (fr) * 2006-06-13 2007-12-14 Sanofi Aventis Sa Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
US7973050B2 (en) 2006-09-26 2011-07-05 Crestone, Inc. Enantiomeric compounds with antibacterial activity
US8697720B2 (en) 2006-09-26 2014-04-15 Crestone, Inc. Substituted phenylether-thienopyridone compounds with antibacterial activity
WO2008039640A2 (en) * 2006-09-26 2008-04-03 Crestone, Inc. Enantiomeric compounds with antibacterial activity
US7994192B2 (en) 2006-09-26 2011-08-09 Crestone, Inc. Substituted thienopyridone compounds with antibacterial activity
WO2008039642A2 (en) 2006-09-26 2008-04-03 Replidyne, Inc. Methods and compounds for treatment of clostridium based infection
WO2008039639A2 (en) * 2006-09-26 2008-04-03 Crestone, Inc. Substituted thienopyridone compounds with antibacterial activity
CN104546857B (zh) * 2013-10-18 2017-01-04 北京北科德源生物医药科技有限公司 化合物naphthoylenequinazolone的抗菌用途
WO2018178041A1 (en) * 2017-03-30 2018-10-04 F. Hoffmann-La Roche Ag Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
CN112939860B (zh) * 2019-11-11 2022-11-11 山东畜牧兽医职业学院 一种治疗耐药性革兰阴阳性菌的化合物及其制备方法
CN115667220A (zh) * 2020-05-20 2023-01-31 豪夫迈·罗氏有限公司 质谱用苄基吡啶鎓试剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005205A (en) * 1974-04-24 1977-01-25 Smith Kline & French Laboratories Limited Compositions and methods for inhibiting H2 histamine receptors
GB8332091D0 (en) * 1983-12-01 1984-01-11 Smith Kline French Lab Chemical compounds
KR950005301B1 (ko) 1990-09-04 1995-05-23 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체
KR960007566A (ko) 1994-08-19 1996-03-22 김정규 신규한 퀴놀릴아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도

Also Published As

Publication number Publication date
US6320051B1 (en) 2001-11-20
PL343680A1 (en) 2001-08-27
IL138906A0 (en) 2001-11-25
TR200003170T2 (tr) 2001-01-22
CO5080763A1 (es) 2001-09-25
KR20010043131A (ko) 2001-05-25
AU3523599A (en) 1999-11-16
HUP0103093A3 (en) 2002-03-28
CN1307565A (zh) 2001-08-08
EP1084110A1 (en) 2001-03-21
NO20005400D0 (no) 2000-10-26
JP2002513005A (ja) 2002-05-08
AR018199A1 (es) 2001-10-31
WO1999055677A1 (en) 1999-11-04
BR9909994A (pt) 2000-12-26
NO20005400L (no) 2000-10-26
CA2330564A1 (en) 1999-11-04

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