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HUP0003261A2 - Multiple functionalities within an array element and uses thereof - Google Patents

Multiple functionalities within an array element and uses thereof

Info

Publication number
HUP0003261A2
HUP0003261A2 HU0003261A HUP0003261A HUP0003261A2 HU P0003261 A2 HUP0003261 A2 HU P0003261A2 HU 0003261 A HU0003261 A HU 0003261A HU P0003261 A HUP0003261 A HU P0003261A HU P0003261 A2 HUP0003261 A2 HU P0003261A2
Authority
HU
Hungary
Prior art keywords
nucleic acid
acid molecules
array element
subject
multiple functionalities
Prior art date
Application number
HU0003261A
Other languages
Hungarian (hu)
Inventor
Kristen Moynihan
John C. Tabone
Jeffrey Van Ness
Original Assignee
Qiagen Genomics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qiagen Genomics, Inc. filed Critical Qiagen Genomics, Inc.
Publication of HUP0003261A2 publication Critical patent/HUP0003261A2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Atalálmány tárgya nukleinsavmolekulák mátrixa, amely egy, felszínénegymástól különálló területeken nukleinsavmolekulákat tartalmazófelszínű szilárd hordozót tartalmaz, amely területek közül legalábbegy különálló terület legalább két, kiválasztott módon különbözőszekvenciájú nukleinsavmolekulát tartalmaz. Atalálmány tárgyát képeziktovábbá eljárások hibridizációs analízisre, továbbá egy mintanukleinsavmolekuláinak azonosítására a találmány szerintinukleinsavmolekulák alkalmazásával. Atalálmány szerinti mátrixoknagyszámú minta párhuzamos tesztelésére alkalmasak. ÓThe subject of the invention is a matrix of nucleic acid molecules, which contains a solid support with a surface containing nucleic acid molecules in separate areas on its surface, of which at least one separate area contains at least two nucleic acid molecules of different sequences in a selected manner. Further methods for hybridization analysis and the identification of nucleic acid molecules of a sample using the nucleic acid molecules according to the invention are the subject of the invention. Matrices according to the invention are suitable for parallel testing of a large number of samples. HE

HU0003261A 1997-07-22 1998-07-21 Multiple functionalities within an array element and uses thereof HUP0003261A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5343697P 1997-07-22 1997-07-22

Publications (1)

Publication Number Publication Date
HUP0003261A2 true HUP0003261A2 (en) 2001-01-29

Family

ID=21984219

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003261A HUP0003261A2 (en) 1997-07-22 1998-07-21 Multiple functionalities within an array element and uses thereof

Country Status (8)

Country Link
EP (1) EP1003910A1 (en)
JP (1) JP2001511360A (en)
CN (1) CN1268979A (en)
AU (1) AU742599B2 (en)
CA (1) CA2298017A1 (en)
HU (1) HUP0003261A2 (en)
NZ (1) NZ501775A (en)
WO (1) WO1999005320A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2335951C (en) 1998-06-24 2013-07-30 Mark S. Chee Decoding of array sensors with microspheres
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
DE19957827C2 (en) * 1999-11-25 2003-06-12 Epigenomics Ag Use of an oligomer array with PNA and / or DNA oligomers on a surface
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
FR2805348B1 (en) * 2000-02-23 2002-07-12 Commissariat Energie Atomique BIOLOGICAL TARGET ANALYSIS USING A BIOCHIP COMPRISING A FLUORESCENT MARKER
US6316608B1 (en) * 2000-03-20 2001-11-13 Incyte Genomics, Inc. Combined polynucleotide sequence as discrete assay endpoints
US7091033B2 (en) 2000-07-21 2006-08-15 Phase-1 Molecular Toxicology, Inc. Array of toxicologically relevant canine genes and uses thereof
GB0105787D0 (en) * 2001-03-08 2001-04-25 Expresson Biosystems Ltd Complex element micro-array and methods of use
AU2003224674A1 (en) * 2002-03-11 2003-09-29 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
EP2259068B1 (en) 2003-01-16 2013-08-14 caprotec bioanalytics GmbH Capture compounds and methods for analyzing the proteome
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
DE102005056639A1 (en) * 2005-11-28 2007-06-06 Advalytix Ag Method, device and kit for the study of macromolecules in a sample
WO2008080531A2 (en) * 2007-01-05 2008-07-10 Advalytix Ag Method, device, and kit for analyzing a liquid sample
JP5100541B2 (en) * 2008-07-04 2012-12-19 古河電気工業株式会社 Immunochromatographic conjugate pad containing fluorescent particles and colored particles as labeled particles, immunochromatographic test strip using the same, and inspection method
SG11201606921PA (en) * 2014-01-28 2016-10-28 Dice Molecules Sv Llc Monoliths with attached recognition compounds, arrays thereof and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0175776B1 (en) * 1984-04-05 1991-07-31 Howard Florey Institute Of Experimental Physiology And Medicine Hybridization histochemistry
GB8910880D0 (en) * 1989-05-11 1989-06-28 Amersham Int Plc Sequencing method
US5858659A (en) * 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
AU1608095A (en) * 1994-01-26 1995-08-15 Hybridon, Inc. Method of detecting sub-ppb levels of oligonucleotides in biological fluids
JP2000513921A (en) * 1995-03-04 2000-10-24 ベーリンガー マンハイム ゲーエムベーハー Sequence-specific detection of nucleic acids
GB9507238D0 (en) * 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations

Also Published As

Publication number Publication date
CN1268979A (en) 2000-10-04
AU8503198A (en) 1999-02-16
EP1003910A1 (en) 2000-05-31
JP2001511360A (en) 2001-08-14
NZ501775A (en) 2001-08-31
CA2298017A1 (en) 1999-02-04
WO1999005320A1 (en) 1999-02-04
AU742599B2 (en) 2002-01-10

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