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HU203564B - Process for producing new orthorombos cyclosporin without solvatation - Google Patents

Process for producing new orthorombos cyclosporin without solvatation Download PDF

Info

Publication number
HU203564B
HU203564B HU886374A HU637488A HU203564B HU 203564 B HU203564 B HU 203564B HU 886374 A HU886374 A HU 886374A HU 637488 A HU637488 A HU 637488A HU 203564 B HU203564 B HU 203564B
Authority
HU
Hungary
Prior art keywords
cyclosporin
orthorhombic
treatment
polyethylene glycol
particle size
Prior art date
Application number
HU886374A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT49893A (en
Inventor
Danielle Giron
Martin List
Friedrich Richter
Yasuyuki Uike
Hans Peter Weber
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of HUT49893A publication Critical patent/HUT49893A/hu
Publication of HU203564B publication Critical patent/HU203564B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
HU886374A 1987-12-21 1988-12-09 Process for producing new orthorombos cyclosporin without solvatation HU203564B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US17261388A 1988-03-24 1988-03-24
US21254888A 1988-06-28 1988-06-28

Publications (2)

Publication Number Publication Date
HUT49893A HUT49893A (en) 1989-11-28
HU203564B true HU203564B (en) 1991-08-28

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
HU886374A HU203564B (en) 1987-12-21 1988-12-09 Process for producing new orthorombos cyclosporin without solvatation

Country Status (27)

Country Link
JP (1) JPH0791316B2 (ko)
KR (1) KR100188305B1 (ko)
AT (1) AT403163B (ko)
AU (1) AU626274B2 (ko)
BE (1) BE1002665A4 (ko)
CA (1) CA1341396C (ko)
CH (1) CH677926A5 (ko)
CY (1) CY1799A (ko)
DE (1) DE3843054C2 (ko)
DK (1) DK175220B1 (ko)
ES (1) ES2012580A6 (ko)
FI (1) FI89065C (ko)
FR (1) FR2624863B1 (ko)
GB (1) GB2211848B (ko)
GR (1) GR1002486B (ko)
HK (1) HK102894A (ko)
HU (1) HU203564B (ko)
IE (1) IE62006B1 (ko)
IL (1) IL88719A0 (ko)
IT (1) IT1235356B (ko)
LU (1) LU87409A1 (ko)
MY (1) MY103943A (ko)
NL (1) NL195096C (ko)
NO (1) NO177228C (ko)
NZ (1) NZ227384A (ko)
SE (1) SE503174C2 (ko)
SG (1) SG99494G (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ATE147619T1 (de) * 1992-05-13 1997-02-15 Sandoz Ag Opthalmische zusammensetzungen enthaltend ein cyclosporin
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
AU715165B2 (en) 1994-11-03 2000-01-20 Novartis Ag Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
US6262054B1 (en) 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
CZ295207B6 (cs) 1997-01-30 2005-06-15 Novartis Ag Tvrdá želatinová tobolka obsahující cyklosporin A
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1706095B1 (en) 2004-01-20 2008-12-24 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
MY180581A (en) * 2011-05-27 2020-12-02 Allergan Inc A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof
RU2639393C2 (ru) 2011-11-15 2017-12-21 Аллерган, Инк. Состав пролонгированного действия циклоспорина формы 2
CN108714137B (zh) 2011-11-15 2022-02-01 阿勒根公司 环孢菌素a形式2的可热压性悬浮液
WO2013074608A1 (en) * 2011-11-15 2013-05-23 Allergan, Inc. Cyclosporine a form 2 and method of making same
JP6363506B2 (ja) * 2011-11-15 2018-07-25 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ２型の懸濁剤
TW202430537A (zh) * 2022-10-20 2024-08-01 日商中外製藥股份有限公司 環狀胜肽的結晶的製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (ko) * 1975-11-04 1979-12-28 Sandoz Ag
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Also Published As

Publication number Publication date
FI89065C (fi) 1993-09-30
JPH0791316B2 (ja) 1995-10-04
DK175220B1 (da) 2004-07-12
NO177228C (no) 1995-08-09
CH677926A5 (ko) 1991-07-15
SE8804570D0 (sv) 1988-12-19
FI885869A (fi) 1989-06-22
SE8804570L (sv) 1989-06-22
DE3843054C2 (de) 2003-08-21
IL88719A0 (en) 1989-07-31
DK705488A (da) 1989-06-22
IE883779L (en) 1989-06-21
GB2211848B (en) 1991-11-06
GB8829556D0 (en) 1989-02-08
IT8848690A0 (it) 1988-12-20
NO885625L (no) 1989-06-22
GB2211848A (en) 1989-07-12
ATA309588A (de) 1997-04-15
AU626274B2 (en) 1992-07-30
DE3843054A1 (de) 1989-07-27
BE1002665A4 (fr) 1991-04-30
FI885869A0 (fi) 1988-12-19
NL195096C (nl) 2004-02-09
HK102894A (en) 1994-09-30
AT403163B (de) 1997-11-25
HUT49893A (en) 1989-11-28
GR1002486B (el) 1996-12-09
IT1235356B (it) 1992-06-30
IE62006B1 (en) 1994-12-14
KR890009975A (ko) 1989-08-05
LU87409A1 (fr) 1989-07-07
JPH01211598A (ja) 1989-08-24
ES2012580A6 (es) 1990-04-01
NL8803125A (nl) 1989-07-17
NO885625D0 (no) 1988-12-19
SE503174C2 (sv) 1996-04-15
NZ227384A (en) 1991-09-25
SG99494G (en) 1994-10-28
MY103943A (en) 1993-10-30
DK705488D0 (da) 1988-12-19
NO177228B (no) 1995-05-02
FR2624863A1 (fr) 1989-06-23
CA1341396C (en) 2002-11-05
CY1799A (en) 1995-02-17
GR880100850A (el) 1994-03-31
AU2705588A (en) 1989-06-22
KR100188305B1 (ko) 1999-06-01
FR2624863B1 (fr) 1991-04-26
FI89065B (fi) 1993-04-30

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Legal Events

Date Code Title Description
HPC4 Succession in title of patentee

Owner name: NOVARTIS AG, CH